SEQUENCE LISTING


<110> Hyseq, Inc

<120>  NOVEL NUCLEIC ACIDS AND POLYPEPTIDES

<130>  21272-095-061

<140>  NOT YET ASSIGNED

<141>  2002-1-29

<150>  09/774,528
<151>  2001-01-30

<160>  438    


      <210> 1
      <211> 4003
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (427)..(3825)

      <400> 1
 gcttagataa acttaagaga ctagggtcct ggatggaact ttattattaa cttcaagttt     60

 ccttttaggc aggggaatta ttcccattcc taaaatgagg gaatggaaat agatgttcta    120

 tcatggctct aattctgtaa aagtgtaaaa agatggatta cagtgataca aatgtggtat    180

 aaaaagttgt ggaataagac tggacttgtg gttctttttc aacagtttaa ttgaaaagaa    240

 agacactcaa tttttttcct ttttctttat tttcaggtta tatttcacac tatgtgctga    300

 ctgtatctac agaagatatt taaaaaaaaa aaagataaac tttttttcaa agattttgat    360

 tccaggggaa tctttgcttt aaatttgtgt gtgtgtttgt gttcgtgaat tgtaactcca    420

 gaagca   atg cct gta caa gct cca caa tgg acg gat ttc ctc tcc tgc     468
          Met Pro Val Gln Ala Pro Gln Trp Thr Asp Phe Leu Ser Cys
            1               5                  10

 cca att tgc act cag act ttc gac gaa aca att cga aag ccc atc agt      516
 Pro Ile Cys Thr Gln Thr Phe Asp Glu Thr Ile Arg Lys Pro Ile Ser
  15                  20                  25                  30

 ttg ggt tgt ggc cat act gtc tgc aag atg tgc ctg aat aaa ctc cac      564
 Leu Gly Cys Gly His Thr Val Cys Lys Met Cys Leu Asn Lys Leu His
                  35                  40                  45

 cgc aag gct tgc cca ttt gac cag acc act atc aat aca gac att gag      612
 Arg Lys Ala Cys Pro Phe Asp Gln Thr Thr Ile Asn Thr Asp Ile Glu
              50                  55                  60

 ctc ctc cct gtg aac tca gca ttg ctg cag ctc gtg ggt gct cag gtc      660
 Leu Leu Pro Val Asn Ser Ala Leu Leu Gln Leu Val Gly Ala Gln Val
          65                  70                  75

 cct gag cag cag cct att act ttg tgt agt ggg gtt gaa gac aca aag      708
 Pro Glu Gln Gln Pro Ile Thr Leu Cys Ser Gly Val Glu Asp Thr Lys
      80                  85                  90

 cat tat gag gaa gcc aag aaa tgt gta gaa gaa tta gca ttg tac tta      756
 His Tyr Glu Glu Ala Lys Lys Cys Val Glu Glu Leu Ala Leu Tyr Leu
  95                 100                 105                 110

 aaa ccg ctc agc agt gct aga gga gtg ggt ctg aac agc act act cag      804
 Lys Pro Leu Ser Ser Ala Arg Gly Val Gly Leu Asn Ser Thr Thr Gln
                 115                 120                 125

 agt gtt ctg agt cgc cca atg cag agg aag ctt gtg act cta gtc cac      852
 Ser Val Leu Ser Arg Pro Met Gln Arg Lys Leu Val Thr Leu Val His
             130                 135                 140

 tgt caa cta gta gaa gaa gaa ggc agg att cgt gcc atg agg gca gct      900
 Cys Gln Leu Val Glu Glu Glu Gly Arg Ile Arg Ala Met Arg Ala Ala
         145                 150                 155

 cga tct tta ggt gaa cga aca gtt aca gag ctc att ctc cag cac cag      948
 Arg Ser Leu Gly Glu Arg Thr Val Thr Glu Leu Ile Leu Gln His Gln
     160                 165                 170

 aat cct cag caa ctc tct tcc aat ctt tgg gca gca gta agg gct agg      996
 Asn Pro Gln Gln Leu Ser Ser Asn Leu Trp Ala Ala Val Arg Ala Arg
 175                 180                 185                 190

 gga tgc cag ttc ctt gga cca gca atg cag gag gaa gct tta aag ttg     1044
 Gly Cys Gln Phe Leu Gly Pro Ala Met Gln Glu Glu Ala Leu Lys Leu
                 195                 200                 205

 gtt ctg ctg gcc tta gaa gat ggt tct gct ttg tca aga aaa gta ttg     1092
 Val Leu Leu Ala Leu Glu Asp Gly Ser Ala Leu Ser Arg Lys Val Leu
             210                 215                 220

 gtt ctg ttt gtg gtg caa aga ttg gag cca cgg ttt cct caa gcc tct     1140
 Val Leu Phe Val Val Gln Arg Leu Glu Pro Arg Phe Pro Gln Ala Ser
         225                 230                 235

 aaa act agc att ggg cat gtt gtt cag ctc ctt tat aga gcc tcc tgt     1188
 Lys Thr Ser Ile Gly His Val Val Gln Leu Leu Tyr Arg Ala Ser Cys
     240                 245                 250

 ttc aag gtc acc aaa cgt gat gaa gac tct tct ttg atg cag ctg aaa     1236
 Phe Lys Val Thr Lys Arg Asp Glu Asp Ser Ser Leu Met Gln Leu Lys
 255                 260                 265                 270

 gaa gaa ttt aga acc tat gaa gct ctg cgg cga gaa cat gac tcc cag     1284
 Glu Glu Phe Arg Thr Tyr Glu Ala Leu Arg Arg Glu His Asp Ser Gln
                 275                 280                 285

 ata gtg cag att gct atg gaa gca ggc tta cga att gca ccg gac cag     1332
 Ile Val Gln Ile Ala Met Glu Ala Gly Leu Arg Ile Ala Pro Asp Gln
             290                 295                 300

 tgg tcc tct ttg ctt tat gga gac cag tct cac aaa tct cat atg cag     1380
 Trp Ser Ser Leu Leu Tyr Gly Asp Gln Ser His Lys Ser His Met Gln
         305                 310                 315

 tcc att att gac aag act cca gcc tct ttt gca cag agt gtt cag gaa     1428
 Ser Ile Ile Asp Lys Thr Pro Ala Ser Phe Ala Gln Ser Val Gln Glu
     320                 325                 330

 cta aca att gct ctc cag cga act gga gac cca gca aac ttg aac cga     1476
 Leu Thr Ile Ala Leu Gln Arg Thr Gly Asp Pro Ala Asn Leu Asn Arg
 335                 340                 345                 350

 cta aga ccc cat ttg gag ctg tta gca aac att gac cct agt cca gat     1524
 Leu Arg Pro His Leu Glu Leu Leu Ala Asn Ile Asp Pro Ser Pro Asp
                 355                 360                 365

 gct cct cct cct act tgg gaa cag ctg gaa aat ggc ctg gtt gct gtg     1572
 Ala Pro Pro Pro Thr Trp Glu Gln Leu Glu Asn Gly Leu Val Ala Val
             370                 375                 380

 cgt aca gtg gta cat ggg ctg gtt gat tat atc cag aac cac agc aaa     1620
 Arg Thr Val Val His Gly Leu Val Asp Tyr Ile Gln Asn His Ser Lys
         385                 390                 395

 aaa gga gca gat cag cag cag cct cca cag cat agc aaa tac aaa aca     1668
 Lys Gly Ala Asp Gln Gln Gln Pro Pro Gln His Ser Lys Tyr Lys Thr
     400                 405                 410

 tac atg tgt cga gat atg aag cag aga gga gga tgc cct cgt ggg gcc     1716
 Tyr Met Cys Arg Asp Met Lys Gln Arg Gly Gly Cys Pro Arg Gly Ala
 415                 420                 425                 430

 agc tgt aca ttt gca cac tca cag gag gaa ctg gaa aaa ttt cgt aaa     1764
 Ser Cys Thr Phe Ala His Ser Gln Glu Glu Leu Glu Lys Phe Arg Lys
                 435                 440                 445

 atg aat aag cgc ctg gtt ccg aga aga ccc ttg agt gcc tct ttg ggt     1812
 Met Asn Lys Arg Leu Val Pro Arg Arg Pro Leu Ser Ala Ser Leu Gly
             450                 455                 460

 caa ctt aat gag gtg ggc ctg cct tca gca gct atc ctt cca gat gaa     1860
 Gln Leu Asn Glu Val Gly Leu Pro Ser Ala Ala Ile Leu Pro Asp Glu
         465                 470                 475

 ggt gca gtg gat ctc cct agc aga aaa cct cct gct ctg cca aat gga     1908
 Gly Ala Val Asp Leu Pro Ser Arg Lys Pro Pro Ala Leu Pro Asn Gly
     480                 485                 490

 att gta tca aca ggg aat aca gta aca cag ctt att ccg cga ggg aca     1956
 Ile Val Ser Thr Gly Asn Thr Val Thr Gln Leu Ile Pro Arg Gly Thr
 495                 500                 505                 510

 gac ccc agc tat gat tct agt ctg aaa cca gga aaa ata gat cat ctg     2004
 Asp Pro Ser Tyr Asp Ser Ser Leu Lys Pro Gly Lys Ile Asp His Leu
                 515                 520                 525

 agc agt agt gct cct gga tcc cct cct gac ctg cta gaa tct gtt cct     2052
 Ser Ser Ser Ala Pro Gly Ser Pro Pro Asp Leu Leu Glu Ser Val Pro
             530                 535                 540

 aag agt att tct gcc tta cct gtg aat cca cat tct ata cct cca agg     2100
 Lys Ser Ile Ser Ala Leu Pro Val Asn Pro His Ser Ile Pro Pro Arg
         545                 550                 555

 ggg cca gca gat ctg cct cca atg cct gtt acc aaa cca ctt cag atg     2148
 Gly Pro Ala Asp Leu Pro Pro Met Pro Val Thr Lys Pro Leu Gln Met
     560                 565                 570

 gta cct cga ggt tct cag tta tat cca gca caa cag acg gat gtt tat     2196
 Val Pro Arg Gly Ser Gln Leu Tyr Pro Ala Gln Gln Thr Asp Val Tyr
 575                 580                 585                 590

 tat cag gat cct cga gga gca gct ccg cca ttt gaa cca gca cct tat     2244
 Tyr Gln Asp Pro Arg Gly Ala Ala Pro Pro Phe Glu Pro Ala Pro Tyr
                 595                 600                 605

 cag cag ggt atg tat tat act cca cca cca caa tgt gtg tcc cgc ttt     2292
 Gln Gln Gly Met Tyr Tyr Thr Pro Pro Pro Gln Cys Val Ser Arg Phe
             610                 615                 620

 gtc cga cct cca cca tct gct cct gaa cct gct cct ccc tac ttg gat     2340
 Val Arg Pro Pro Pro Ser Ala Pro Glu Pro Ala Pro Pro Tyr Leu Asp
         625                 630                 635

 cat tat cca ccc tac ctc caa gaa cgt gtt gta aac tct cag tat ggc     2388
 His Tyr Pro Pro Tyr Leu Gln Glu Arg Val Val Asn Ser Gln Tyr Gly
     640                 645                 650

 aca cag cca cag cag tac cca cct ata tac cca tct cac tat gat ggc     2436
 Thr Gln Pro Gln Gln Tyr Pro Pro Ile Tyr Pro Ser His Tyr Asp Gly
 655                 660                 665                 670

 cgt cga gtg tac cct gct ccg tct tac aca aga gaa gag ata ttc cga     2484
 Arg Arg Val Tyr Pro Ala Pro Ser Tyr Thr Arg Glu Glu Ile Phe Arg
                 675                 680                 685

 gaa agc cct ata ccc att gag att cca cct gca gca gta cca tcg tat     2532
 Glu Ser Pro Ile Pro Ile Glu Ile Pro Pro Ala Ala Val Pro Ser Tyr
             690                 695                 700

 gta cca gaa tcc aga gaa aga tac caa cag atc gag agt tac tat cca     2580
 Val Pro Glu Ser Arg Glu Arg Tyr Gln Gln Ile Glu Ser Tyr Tyr Pro
         705                 710                 715

 gtg gct cct cat cca act cag atc aga cct tcg tac ctc aga gaa cct     2628
 Val Ala Pro His Pro Thr Gln Ile Arg Pro Ser Tyr Leu Arg Glu Pro
     720                 725                 730

 cct tat agc cgg ctt cct cct cct ccc cag cct cat cct agt cta gat     2676
 Pro Tyr Ser Arg Leu Pro Pro Pro Pro Gln Pro His Pro Ser Leu Asp
 735                 740                 745                 750

 gaa cta cat cgc cga cga aag gaa ata atg gcc cag cta gag gaa aga     2724
 Glu Leu His Arg Arg Arg Lys Glu Ile Met Ala Gln Leu Glu Glu Arg
                 755                 760                 765

 aag gtt atc tct cca cct cct ttt gca cct tca cca acc ttg cct cct     2772
 Lys Val Ile Ser Pro Pro Pro Phe Ala Pro Ser Pro Thr Leu Pro Pro
             770                 775                 780

 acc ttt cat ccg gaa gaa ttt ttg gat gaa gac ttg aag gta gct ggg     2820
 Thr Phe His Pro Glu Glu Phe Leu Asp Glu Asp Leu Lys Val Ala Gly
         785                 790                 795

 aaa tac aaa gga aat gat tat agc caa tac tct ccc tgg tca tgt gac     2868
 Lys Tyr Lys Gly Asn Asp Tyr Ser Gln Tyr Ser Pro Trp Ser Cys Asp
     800                 805                 810

 acc atc ggc tcc tac att gga acc aaa gat gca aaa ccc aaa gat gtt     2916
 Thr Ile Gly Ser Tyr Ile Gly Thr Lys Asp Ala Lys Pro Lys Asp Val
 815                 820                 825                 830

 gtg gca gca ggg agt gtg gaa atg atg aat gtg gag agt aaa gga atg     2964
 Val Ala Ala Gly Ser Val Glu Met Met Asn Val Glu Ser Lys Gly Met
                 835                 840                 845

 agg gac cag cga tta gat ctt cag aga aga gca gca gaa acc agt gat     3012
 Arg Asp Gln Arg Leu Asp Leu Gln Arg Arg Ala Ala Glu Thr Ser Asp
             850                 855                 860

 gat gac ctc atc cca ttt gga gac cga cca aca gtg tct cgg ttt ggt     3060
 Asp Asp Leu Ile Pro Phe Gly Asp Arg Pro Thr Val Ser Arg Phe Gly
         865                 870                 875

 gcc atc tca cga act tcc aaa act ata tat cag ggt gct ggt cca atg     3108
 Ala Ile Ser Arg Thr Ser Lys Thr Ile Tyr Gln Gly Ala Gly Pro Met
     880                 885                 890

 cag gct atg gca cct cag gga gct cct aca aaa tct att aac att tca     3156
 Gln Ala Met Ala Pro Gln Gly Ala Pro Thr Lys Ser Ile Asn Ile Ser
 895                 900                 905                 910

 gat tat agt cca tat gga acc cac ggt ggc tgg gga gct tct cca tat     3204
 Asp Tyr Ser Pro Tyr Gly Thr His Gly Gly Trp Gly Ala Ser Pro Tyr
                 915                 920                 925

 tca cct cat caa aac ata cct tct cag gga cac ttc agt gag agg gag     3252
 Ser Pro His Gln Asn Ile Pro Ser Gln Gly His Phe Ser Glu Arg Glu
             930                 935                 940

 aga ata tct atg tca gaa gtg gcc agt cat gga aaa ccc ctt cca tct     3300
 Arg Ile Ser Met Ser Glu Val Ala Ser His Gly Lys Pro Leu Pro Ser
         945                 950                 955

 gct gag aga gaa cag cta cga cta gaa ttg cag caa ttg aac cat cag     3348
 Ala Glu Arg Glu Gln Leu Arg Leu Glu Leu Gln Gln Leu Asn His Gln
     960                 965                 970

 att agc cag cag acc cag cta cgt gga cta gag gct gtt agt aac agg     3396
 Ile Ser Gln Gln Thr Gln Leu Arg Gly Leu Glu Ala Val Ser Asn Arg
 975                 980                 985                 990

 ctg gtg ttg cag agg gag gca aac acc ctg gca ggc cag tca cag ccc     3444
 Leu Val Leu Gln Arg Glu Ala Asn Thr Leu Ala Gly Gln Ser Gln Pro
                 995                1000                1005

 cca cca ccg cca cct cca aaa tgg cct ggg atg atc tca agt gag cag     3492
 Pro Pro Pro Pro Pro Pro Lys Trp Pro Gly Met Ile Ser Ser Glu Gln
            1010                1015                1020

 ttg agc ttg gaa ctg cac cag gtg gaa agg gaa atc ggg aag aga aca     3540
 Leu Ser Leu Glu Leu His Gln Val Glu Arg Glu Ile Gly Lys Arg Thr
        1025                1030                1035

 cgg gaa ctg agt atg gaa aac cag tgt tct ctg gac atg aaa agc aaa     3588
 Arg Glu Leu Ser Met Glu Asn Gln Cys Ser Leu Asp Met Lys Ser Lys
    1040                1045                1050

 ctg aat aca agt aaa caa gca gaa aat gga caa cca gaa cca caa aac     3636
 Leu Asn Thr Ser Lys Gln Ala Glu Asn Gly Gln Pro Glu Pro Gln Asn
1055                1060                1065                1070

 aag gtt ccg gct gag gac ctt aca ttg aca ttc agc agt gat gta cca     3684
 Lys Val Pro Ala Glu Asp Leu Thr Leu Thr Phe Ser Ser Asp Val Pro
                1075                1080                1085

 aat gga tca gcc ttg aca caa gag aat atc agc ctc cta tca aac aag     3732
 Asn Gly Ser Ala Leu Thr Gln Glu Asn Ile Ser Leu Leu Ser Asn Lys
            1090                1095                1100

 acc agc tct ctg aac ctg tca gag gac cct gag gga gga ggg gat aat     3780
 Thr Ser Ser Leu Asn Leu Ser Glu Asp Pro Glu Gly Gly Gly Asp Asn
        1105                1110                1115

 aat gac tcc cag aga tca gga gtt act ccc agt tct gct cct taa aat     3828
 Asn Asp Ser Gln Arg Ser Gly Val Thr Pro Ser Ser Ala Pro 
    1120                1125                1130

 atgaggagtc ctacttttat cttctgctcc taatcagttt gtcgggcata ggggtaggag   3888

 aacgcataat tctaaatttt ctcttaagag cggtcagaga aatcaggaat tcaccagagc   3948

 aatgtgcaca aacaccatac taaaaacaaa cctgcacata gttcacatta tgcat        4003




      <210> 2
      <211> 1793
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (756)..(1667)

      <400> 2
 cggctgcgga ggcgatctcc ctgatttagg gttttagttg cccggagcct gccaccgctc     60

 tcagccagcc cgcatccttc tctgttcttc cctccccccg cctgccacgg cgcgggtatc    120

 cgcagccaca gcccggggcc ggtgaggcgg cgaaggggga ggggaggaat caagggatga    180

 gcgccggaag ggcgtcgggg gccctgagcc gcactaggac gcccctggag ccggaacccc    240

 agcagaagcc ggaaccagaa ccaaatcacc ggtaccgggt cggccaggtg gtcagggtgg    300

 gagaaaccaa aaagggagag gggtgcggga gtactgagag gaaggggctg caaaggcctg    360

 gctcaggccg gcgtggagga ggtgcgggcg ctgactcagg caggatttct gctcccgccg    420

 cctaagaatg ccgtcccatc tcgtgctgca gtgtccttgg gagggacaga agcgcgaaca    480

 agctggaaag gggaacgctc ggggcgtcgg ggaagcggga ccagggtcgt ggtagagagc    540

 ttgcgttgcc gctgacctct tgccgaaagg cgaaacagca ctcctggccc ggacagctcc    600

 ctggttgggt agggggtggg gccggacctc agccggacgt cttagacgtg cttgtttcag    660

 atcctgagga cggcattcct acccctcccc cattcccagc tgcagccccc taaacccagg    720

 aggcgccctg gcccgcgctc gccccccagg gcctc   atg tcg gaa cca cag cct     773
                                          Met Ser Glu Pro Gln Pro
                                            1               5

 gac ctg gaa ccg ccc caa cat ggg cta tat atg ctc ttc ctg ctt gtg      821
 Asp Leu Glu Pro Pro Gln His Gly Leu Tyr Met Leu Phe Leu Leu Val
              10                  15                  20

 ctg gtc ttc ttc ctc atg ggc ctg gta ggc ttc atg atc tgc cac gtg      869
 Leu Val Phe Phe Leu Met Gly Leu Val Gly Phe Met Ile Cys His Val
          25                  30                  35

 ctc aag aag aag ggc tac cgc tgc cgc acg tcg agg ggc tct gag cct      917
 Leu Lys Lys Lys Gly Tyr Arg Cys Arg Thr Ser Arg Gly Ser Glu Pro
      40                  45                  50

 gac gat gcc cag ctt cag ccc cct gag gac gat gac atg aat gag gac      965
 Asp Asp Ala Gln Leu Gln Pro Pro Glu Asp Asp Asp Met Asn Glu Asp
  55                  60                  65                  70

 aca gta gag agg att gtt cgc tgc atc atc cag aat gaa gcc aat gct     1013
 Thr Val Glu Arg Ile Val Arg Cys Ile Ile Gln Asn Glu Ala Asn Ala
                  75                  80                  85

 gag gcc ttg aag gag atg ctg ggg gac agt gaa gga gaa ggg aca gtg     1061
 Glu Ala Leu Lys Glu Met Leu Gly Asp Ser Glu Gly Glu Gly Thr Val
              90                  95                 100

 cag ctg tcc agt gtg gat gcc acc tcc agc ctg cag gac gga gcc ccc     1109
 Gln Leu Ser Ser Val Asp Ala Thr Ser Ser Leu Gln Asp Gly Ala Pro
         105                 110                 115

 tcc cat cat cac aca gtg cac ctg ggc tct gca gcc cct tgc ctc cat     1157
 Ser His His His Thr Val His Leu Gly Ser Ala Ala Pro Cys Leu His
     120                 125                 130

 tgc agc cgc agc aag agg cct cca ctt gtc cgt cag gga cgc tcc aag     1205
 Cys Ser Arg Ser Lys Arg Pro Pro Leu Val Arg Gln Gly Arg Ser Lys
 135                 140                 145                 150

 gaa gga aaa agc cgc ccc cgg aca ggg gag acc act gtg ttc tct gtg     1253
 Glu Gly Lys Ser Arg Pro Arg Thr Gly Glu Thr Thr Val Phe Ser Val
                 155                 160                 165

 ggc agg ttc cgg gtg aca cac att gag aag cgc tat gga ctg cac gaa     1301
 Gly Arg Phe Arg Val Thr His Ile Glu Lys Arg Tyr Gly Leu His Glu
             170                 175                 180

 cac cgt gat ggc tcc ccc aca gac agg agc tgg ggc tct ggt ggg gga     1349
 His Arg Asp Gly Ser Pro Thr Asp Arg Ser Trp Gly Ser Gly Gly Gly
         185                 190                 195

 cag gac cca ggg ggt ggt cag ggg tct ggg gga ggg cag ccc aag gca     1397
 Gln Asp Pro Gly Gly Gly Gln Gly Ser Gly Gly Gly Gln Pro Lys Ala
     200                 205                 210

 ggg atg cct gcc atg gag agg ctg ccc cct gag agg cca cag ccc cag     1445
 Gly Met Pro Ala Met Glu Arg Leu Pro Pro Glu Arg Pro Gln Pro Gln
 215                 220                 225                 230

 gtc cta gcc agc ccc cca gta cag aat gga gga ctc agg gac agc agc     1493
 Val Leu Ala Ser Pro Pro Val Gln Asn Gly Gly Leu Arg Asp Ser Ser
                 235                 240                 245

 cta acc cct cgt gca ctt gaa ggg aac ccc aga gct tct gca gag cca     1541
 Leu Thr Pro Arg Ala Leu Glu Gly Asn Pro Arg Ala Ser Ala Glu Pro
             250                 255                 260

 aca ctg agg gcc gga ggg agg ggc cca agc cca ggg ctg ccc act caa     1589
 Thr Leu Arg Ala Gly Gly Arg Gly Pro Ser Pro Gly Leu Pro Thr Gln
         265                 270                 275

 gag gca aat ggg cag cca agc aaa cca gac act tct gat cac cag gtg     1637
 Glu Ala Asn Gly Gln Pro Ser Lys Pro Asp Thr Ser Asp His Gln Val
     280                 285                 290

 tct cta cca cag gga gca ggg agt atg tga g tctccttcat tgtgctgatg     1688
 Ser Leu Pro Gln Gly Ala Gly Ser Met 
 295                 300

 gactaccagc tggcagggcc agggggtggg tgggcgtgaa agccctcccc tccactggac   1748

 agcactgccc cccagctgag ggaccagctc tacttccacc tggag                   1793




      <210> 3
      <211> 1394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(711)

      <400> 3
 aag  atg gct gtg gag ctg ggc gtg ctg ctc gtc cgg ccc cgg ccc gga      48
      Met Ala Val Glu Leu Gly Val Leu Leu Val Arg Pro Arg Pro Gly
        1               5                  10                  15

 acc ggg ctg ggt aga gtg atg cgg acc ctc ctg ctg gtg ctg tgg ctg       96
 Thr Gly Leu Gly Arg Val Met Arg Thr Leu Leu Leu Val Leu Trp Leu
                  20                  25                  30

 gcg acg cgc gga agc gcg ctc tac ttt cac atc gga gag acg gag aag      144
 Ala Thr Arg Gly Ser Ala Leu Tyr Phe His Ile Gly Glu Thr Glu Lys
              35                  40                  45

 aag tgc ttt att gag gag atc ccg gac gag acc atg gtc ata gga aac      192
 Lys Cys Phe Ile Glu Glu Ile Pro Asp Glu Thr Met Val Ile Gly Asn
          50                  55                  60

 tac cgg acg cag ctg tat gac aag cag cgg gag gag tac cag ccg gcc      240
 Tyr Arg Thr Gln Leu Tyr Asp Lys Gln Arg Glu Glu Tyr Gln Pro Ala
      65                  70                  75

 acc ccg ggg ctt ggc atg ttt gtg gag gtg aag gac cca gag gac aag      288
 Thr Pro Gly Leu Gly Met Phe Val Glu Val Lys Asp Pro Glu Asp Lys
  80                  85                  90                  95

 gtc atc ctg gcc cgg cag tat ggc tcc gag ggc agg ttc act ttc act      336
 Val Ile Leu Ala Arg Gln Tyr Gly Ser Glu Gly Arg Phe Thr Phe Thr
                 100                 105                 110

 tcc cat acc cct ggt gag cac cag atc tgt ctt cac tcc aat tcc acc      384
 Ser His Thr Pro Gly Glu His Gln Ile Cys Leu His Ser Asn Ser Thr
             115                 120                 125

 aag ttc tcc ctc ttt gct gga ggc atg ctg aga gtt cac ctg gac atc      432
 Lys Phe Ser Leu Phe Ala Gly Gly Met Leu Arg Val His Leu Asp Ile
         130                 135                 140

 cag gta ggt gaa cat gcc aat gac tat gca gaa att gct gct aaa gac      480
 Gln Val Gly Glu His Ala Asn Asp Tyr Ala Glu Ile Ala Ala Lys Asp
     145                 150                 155

 aag ttg agt gag ttg cag cta cga gtg cga cag ctg gtg gaa caa gtg      528
 Lys Leu Ser Glu Leu Gln Leu Arg Val Arg Gln Leu Val Glu Gln Val
 160                 165                 170                 175

 gag cag atc cag aaa gag cag aac tac cag cgg tgg cga gag gag cgc      576
 Glu Gln Ile Gln Lys Glu Gln Asn Tyr Gln Arg Trp Arg Glu Glu Arg
                 180                 185                 190

 ttc cgg cag acc agt gag agc acc aac cag cgg gtg ctg tgg tgg tcc      624
 Phe Arg Gln Thr Ser Glu Ser Thr Asn Gln Arg Val Leu Trp Trp Ser
             195                 200                 205

 att ctg cag acc ctc atc ctc gtg gcc atc ggt gtc tgg cag atg cgg      672
 Ile Leu Gln Thr Leu Ile Leu Val Ala Ile Gly Val Trp Gln Met Arg
         210                 215                 220

 cac ctc aag agc ttc ttt gaa gcc aag aag ctt gtg tag ctgtcccagg       721
 His Leu Lys Ser Phe Phe Glu Ala Lys Lys Leu Val 
     225                 230                 235

 cgtcacaacc catcctccca ggctggggga gaaaggacct cctggaactg acttcttctg    781

 tcaggaggac tggtttccag ccatacctgt tctggaaggg agaggggctg gaggcaccca    841

 caggcacaag ctgaaggcag cagcttggct aatactgagc aggtagtggg gcaaattcct    901

 gccctctctc tctggcctct gggccgtttg gtagtaatca cccaggggct ggtaaagccc    961

 ctcctcttgg cacctcagaa tcacagtgtt actgatcagg gatgtgaggc tgctgttggg   1021

 ggtgggggga ggggaatggg caggcaagcc agtcttctgt cttcctttgc taacttaggg   1081

 ttttgagcag gttggggtat ggtgcctgtc atacccacct gccaccctgg gaacctcact   1141

 gttctctctt tcagcctaga cctgctgatc cagggtgtgt gtgagttgag ggtgggtgga   1201

 ggggtttgca gtgtgggaat gtggccctgc agttgacctg agctgcttca catggttgtc   1261

 cattctgggg cttaaagaac tgggaccaga ccaagtagag gccttggtgc tggttggggt   1321

 ggggcctgca gagtcttagt tactgatttc attttcaata aatgtaggtt tgttacatga   1381

 gtttcccaat aaa                                                      1394




      <210> 4
      <211> 3505
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (384)..(2939)

      <400> 4
 acctcacggc cggagattcc cgggtcgacc cacgcgtccg gagcaatgga tgaataaaca     60

 tttgttccct ttcataaagc cctgggattc tgctttgtct accttaagtt tatttctcta    120

 aatgatctgt catggaaaga ggatattttg gtatgtttct gcttttttgc atgtgaccca    180

 gaatacgttg gagagatgaa attagacttg ttacctctat tttatgtaca cttaacttag    240

 aatatattaa cttagaatat attgtgaatt aatgggtttt aaaacattta attattggac    300

 taaccattat taccattaaa acatttgttt tatttttcag gatttgtttt cttcaagcat    360

 ttggtcgaga ttaagaatta aaa    atg tca tcc aaa caa gaa ata atg agt     410
                              Met Ser Ser Lys Gln Glu Ile Met Ser
                                1               5

 gac cag cgg ttt aga cgg gtt gca aag gac ccg aga ttt tgg gaa atg      458
 Asp Gln Arg Phe Arg Arg Val Ala Lys Asp Pro Arg Phe Trp Glu Met
  10                  15                  20                  25

 cca gaa aag gat cga aaa gtc aaa att gac aag aga ttt cga gcc atg      506
 Pro Glu Lys Asp Arg Lys Val Lys Ile Asp Lys Arg Phe Arg Ala Met
                  30                  35                  40

 ttt cat gac aag aag ttc aag ttg aac tat gcc gtg gat aaa aga ggg      554
 Phe His Asp Lys Lys Phe Lys Leu Asn Tyr Ala Val Asp Lys Arg Gly
              45                  50                  55

 cgc ccc att agc cat agc act aca gag gat ttg aag cgt ttt tac gac      602
 Arg Pro Ile Ser His Ser Thr Thr Glu Asp Leu Lys Arg Phe Tyr Asp
          60                  65                  70

 ctt tca gat tct gat tcc aat ctc tct ggt gaa gat agc aaa gca ttg      650
 Leu Ser Asp Ser Asp Ser Asn Leu Ser Gly Glu Asp Ser Lys Ala Leu
      75                  80                  85

 agt caa aag aaa ata aag aag aaa aaa acc cag act aaa aaa gaa atc      698
 Ser Gln Lys Lys Ile Lys Lys Lys Lys Thr Gln Thr Lys Lys Glu Ile
  90                  95                 100                 105

 gat tca aaa aat cta gtt gag aaa aag aaa gaa acc aag aag gct aat      746
 Asp Ser Lys Asn Leu Val Glu Lys Lys Lys Glu Thr Lys Lys Ala Asn
                 110                 115                 120

 cac aag ggt tct gaa aat aaa act gat tta gat aat tct ata gga att      794
 His Lys Gly Ser Glu Asn Lys Thr Asp Leu Asp Asn Ser Ile Gly Ile
             125                 130                 135

 aaa aaa atg aaa acc tca tgt aaa ttt aag ata gat tca aac ata agt      842
 Lys Lys Met Lys Thr Ser Cys Lys Phe Lys Ile Asp Ser Asn Ile Ser
         140                 145                 150

 ccg aag aag gat agc aaa gaa ttt aca caa aaa aat aaa aaa aaa aaa      890
 Pro Lys Lys Asp Ser Lys Glu Phe Thr Gln Lys Asn Lys Lys Lys Lys
     155                 160                 165

 aaa aac att gtt caa cat act aca gac tct tct ctc gaa gaa aaa caa      938
 Lys Asn Ile Val Gln His Thr Thr Asp Ser Ser Leu Glu Glu Lys Gln
 170                 175                 180                 185

 agg aca tta gac tca ggc acc tct gaa att gtg aaa tct ccc aga atc      986
 Arg Thr Leu Asp Ser Gly Thr Ser Glu Ile Val Lys Ser Pro Arg Ile
                 190                 195                 200

 gag tgt tct aag aca aga aga gaa atg caa tca gtg gtt caa ctc ata     1034
 Glu Cys Ser Lys Thr Arg Arg Glu Met Gln Ser Val Val Gln Leu Ile
             205                 210                 215

 atg aca aga gac agt gat ggt tat gaa aac cca aca gat ggt gaa atg     1082
 Met Thr Arg Asp Ser Asp Gly Tyr Glu Asn Pro Thr Asp Gly Glu Met
         220                 225                 230

 tgt gac aaa gat gct ctg gag gaa gat tca gaa agc gtt agt gaa ata     1130
 Cys Asp Lys Asp Ala Leu Glu Glu Asp Ser Glu Ser Val Ser Glu Ile
     235                 240                 245

 gga agt gat gag gaa tct gaa aat gaa att aca agt gtt ggt aga gct     1178
 Gly Ser Asp Glu Glu Ser Glu Asn Glu Ile Thr Ser Val Gly Arg Ala
 250                 255                 260                 265

 tca ggt gat gac gat gga agt gaa gat gat gaa gag gag gat gaa gat     1226
 Ser Gly Asp Asp Asp Gly Ser Glu Asp Asp Glu Glu Glu Asp Glu Asp
                 270                 275                 280

 gaa gag gag gat gaa gat gag gat agt gag gat gat gat aaa agt gac     1274
 Glu Glu Glu Asp Glu Asp Glu Asp Ser Glu Asp Asp Asp Lys Ser Asp
             285                 290                 295

 agt ggc cct gat ctt gca agg ggt aaa gga aat ata gaa act agt tct     1322
 Ser Gly Pro Asp Leu Ala Arg Gly Lys Gly Asn Ile Glu Thr Ser Ser
         300                 305                 310

 gaa gat gaa gat gat acg gca gat ttg ttt cca gaa gaa tct ggt ttt     1370
 Glu Asp Glu Asp Asp Thr Ala Asp Leu Phe Pro Glu Glu Ser Gly Phe
     315                 320                 325

 gag cat gct tgg aga gaa tta gat aaa gat gct cct cgt gct gat gag     1418
 Glu His Ala Trp Arg Glu Leu Asp Lys Asp Ala Pro Arg Ala Asp Glu
 330                 335                 340                 345

 att aca cgt cga tta gca gtt tgt aac atg gac tgg gat aga tta aag     1466
 Ile Thr Arg Arg Leu Ala Val Cys Asn Met Asp Trp Asp Arg Leu Lys
                 350                 355                 360

 gca aaa gat ttg ctg gct ctg ttc aat tca ttt aaa ccc aaa gga ggt     1514
 Ala Lys Asp Leu Leu Ala Leu Phe Asn Ser Phe Lys Pro Lys Gly Gly
             365                 370                 375

 gta ata ttt tcc gtc aag ata tat cct tca gaa ttt gga aag gag agg     1562
 Val Ile Phe Ser Val Lys Ile Tyr Pro Ser Glu Phe Gly Lys Glu Arg
         380                 385                 390

 atg aag gaa gag caa gtt caa gga cca gta gag cta tta agt att cct     1610
 Met Lys Glu Glu Gln Val Gln Gly Pro Val Glu Leu Leu Ser Ile Pro
     395                 400                 405

 gaa gat gcc cca gaa aaa gac tgg acg tct aga gaa aaa ttg aga gat     1658
 Glu Asp Ala Pro Glu Lys Asp Trp Thr Ser Arg Glu Lys Leu Arg Asp
 410                 415                 420                 425

 tat caa ttc aaa cga ctg aag tac tat tat gca gta gta gac tgt gat     1706
 Tyr Gln Phe Lys Arg Leu Lys Tyr Tyr Tyr Ala Val Val Asp Cys Asp
                 430                 435                 440

 tct ccg gaa aca gct agt aaa att tat gag gat tgt gat ggc ctg gaa     1754
 Ser Pro Glu Thr Ala Ser Lys Ile Tyr Glu Asp Cys Asp Gly Leu Glu
             445                 450                 455

 ttt gaa agt agt tgt tct ttc ata gat cta agg ttt ata cca gat gat     1802
 Phe Glu Ser Ser Cys Ser Phe Ile Asp Leu Arg Phe Ile Pro Asp Asp
         460                 465                 470

 att act ttt gat gat gag cct aag gat gta gcc tca gaa gtg aat tta     1850
 Ile Thr Phe Asp Asp Glu Pro Lys Asp Val Ala Ser Glu Val Asn Leu
     475                 480                 485

 aca gca tat aaa cca aaa tat ttc act tct gct gca atg gga aca tca     1898
 Thr Ala Tyr Lys Pro Lys Tyr Phe Thr Ser Ala Ala Met Gly Thr Ser
 490                 495                 500                 505

 acg gtg gaa atc act tgg gat gag act gat cat gaa aga att aca atg     1946
 Thr Val Glu Ile Thr Trp Asp Glu Thr Asp His Glu Arg Ile Thr Met
                 510                 515                 520

 ctc aac agg aag ttt aaa aag gaa gag ctt ttg gac atg gat ttt caa     1994
 Leu Asn Arg Lys Phe Lys Lys Glu Glu Leu Leu Asp Met Asp Phe Gln
             525                 530                 535

 gcc tac tta gct tcc tct agt gaa gat gaa gag gag aca gaa gag gag     2042
 Ala Tyr Leu Ala Ser Ser Ser Glu Asp Glu Glu Glu Thr Glu Glu Glu
         540                 545                 550

 cta caa ggt gat gat gga gtc aat gta gaa gaa gat ggg aaa aca aag     2090
 Leu Gln Gly Asp Asp Gly Val Asn Val Glu Glu Asp Gly Lys Thr Lys
     555                 560                 565

 aaa agt cag aag gat gat gaa gaa caa att gct aaa tac agg cag ctc     2138
 Lys Ser Gln Lys Asp Asp Glu Glu Gln Ile Ala Lys Tyr Arg Gln Leu
 570                 575                 580                 585

 ttg cag gtt att caa aaa aaa aaa aaa aaa ggc aaa gaa aat gat atg     2186
 Leu Gln Val Ile Gln Lys Lys Lys Lys Lys Gly Lys Glu Asn Asp Met
                 590                 595                 600

 gaa atg gaa att aaa tgg gtt cca ggt ctt aaa gaa agt gca gaa gag     2234
 Glu Met Glu Ile Lys Trp Val Pro Gly Leu Lys Glu Ser Ala Glu Glu
             605                 610                 615

 atg gtc aaa aac aaa ttg gaa gga aag gat aaa ctg acc cct tgg gaa     2282
 Met Val Lys Asn Lys Leu Glu Gly Lys Asp Lys Leu Thr Pro Trp Glu
         620                 625                 630

 caa ttt tta gag aag aag aaa gag aaa aaa aga ctg aaa agg aaa cag     2330
 Gln Phe Leu Glu Lys Lys Lys Glu Lys Lys Arg Leu Lys Arg Lys Gln
     635                 640                 645

 aag gct ctt gct gaa gag gcc agt gaa gag gaa ctt ccc tct gat gtt     2378
 Lys Ala Leu Ala Glu Glu Ala Ser Glu Glu Glu Leu Pro Ser Asp Val
 650                 655                 660                 665

 gat ttg aat gac cca tac ttt gct gaa gaa gtt aaa caa ata ggt ata     2426
 Asp Leu Asn Asp Pro Tyr Phe Ala Glu Glu Val Lys Gln Ile Gly Ile
                 670                 675                 680

 aat aaa aaa tcg gta aaa tct gca aaa gat ggc aca tct cca gaa gaa     2474
 Asn Lys Lys Ser Val Lys Ser Ala Lys Asp Gly Thr Ser Pro Glu Glu
             685                 690                 695

 gaa att gaa ata gaa aga caa aag gct gaa atg gct ttg ctt atg atg     2522
 Glu Ile Glu Ile Glu Arg Gln Lys Ala Glu Met Ala Leu Leu Met Met
         700                 705                 710

 gat gag gac gag gac agt aag aaa cac ttc aat tac aac aag att gtg     2570
 Asp Glu Asp Glu Asp Ser Lys Lys His Phe Asn Tyr Asn Lys Ile Val
     715                 720                 725

 gag cac cag aat ctg agc aaa aag aag aaa aag cag ctc atg aaa aag     2618
 Glu His Gln Asn Leu Ser Lys Lys Lys Lys Lys Gln Leu Met Lys Lys
 730                 735                 740                 745

 aag gaa tta ata gag gat gac ttt gag gta aat gtt aac gat gca cgg     2666
 Lys Glu Leu Ile Glu Asp Asp Phe Glu Val Asn Val Asn Asp Ala Arg
                 750                 755                 760

 ttt cag gca atg tac act tcc cac ttg ttc aat ttg gac ccc tca gat     2714
 Phe Gln Ala Met Tyr Thr Ser His Leu Phe Asn Leu Asp Pro Ser Asp
             765                 770                 775

 ccc aat ttc aag aaa aca aaa gct atg gaa aaa atc ctt gag gag aag     2762
 Pro Asn Phe Lys Lys Thr Lys Ala Met Glu Lys Ile Leu Glu Glu Lys
         780                 785                 790

 gcc cgg caa aga gaa cgg aaa gaa caa gaa ctt act cag gca ata aag     2810
 Ala Arg Gln Arg Glu Arg Lys Glu Gln Glu Leu Thr Gln Ala Ile Lys
     795                 800                 805

 aaa aaa gag agt gag att gaa aag gaa tca caa agg aag tcc att gat     2858
 Lys Lys Glu Ser Glu Ile Glu Lys Glu Ser Gln Arg Lys Ser Ile Asp
 810                 815                 820                 825

 cct gct ttg tca atg ttg att aaa tct ata aaa acc aaa aca gag cag     2906
 Pro Ala Leu Ser Met Leu Ile Lys Ser Ile Lys Thr Lys Thr Glu Gln
                 830                 835                 840

 ttt caa gca aga aaa aag caa aaa gtc aaa taa ctggatgt tacttatttt     2957
 Phe Gln Ala Arg Lys Lys Gln Lys Val Lys 
             845                 850

 tgaactgaat acatcttttc ctaaaatgta caaaaatagt aggagggaat atttattggg   3017

 aacaaagcta tctttcaaga acatgaataa aatctttttc tggacatagt aaaatttttc   3077

 tccataaata attgtactta attgtggatg actgacaaat ttttattgta tattcctaca   3137

 gatcagtcat aattaaatta cctgcattat agggtttata aaatttttat attttacaat   3197

 gttcagttct aactagtgga aagttactct agctttttaa aaggctgttt acaattctgt   3257

 gtaaaaatag agcagtatct actcaagttt gtgtaaatgt tagggataat ttgaaaaata   3317

 tatatattta atacattaat ttctctggaa gcaggaggca tgtttaaata actattaaaa   3377

 taatttattt ttctagccat aaaggatgga agtcaagaac tttttgttgt ttagtcatgt   3437

 taagtatagt ttatgaaatt aacttgtaaa taaaagtgta aaatattttc attaaaaaaa   3497

 aaaaaaaa                                                            3505




      <210> 5
      <211> 762
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (206)..(643)

      <400> 5
 atacgaagaa ctcggttggc ctcgttggct gcatcgagga agtgtcgcac aatgccatcg     60

 ccgtctactg gaatccgctg gagagctccg ccaagtgcac ctcagaatca acccacactg    120

 ctttgcgttc gcagcctttc cgcttcctgt ttttccctcc gaccaacccc gagcgcaaag    180

 aaattgacct cgcagcggtc ctaca  atg ctt tta tat cat tgg cca agc ttt     232
                              Met Leu Leu Tyr His Trp Pro Ser Phe
                                1               5

 acc ccg ccc ctg cct cat gca gcc tat ggg cta ggc ttt agg gtc cgc      280
 Thr Pro Pro Leu Pro His Ala Ala Tyr Gly Leu Gly Phe Arg Val Arg
  10                  15                  20                  25

 ggt tgg tca gac cgg ggc act tgg cct gaa gac ctg gaa ttg gcg act      328
 Gly Trp Ser Asp Arg Gly Thr Trp Pro Glu Asp Leu Glu Leu Ala Thr
                  30                  35                  40

 tcg ata tta aca agg atg gcg gcg gcc gca gca agt cga gga gtc ggg      376
 Ser Ile Leu Thr Arg Met Ala Ala Ala Ala Ala Ser Arg Gly Val Gly
              45                  50                  55

 gca aag ctg ggc ctg cgt gag att cgc atc cac tta tgt cag cgc tcg      424
 Ala Lys Leu Gly Leu Arg Glu Ile Arg Ile His Leu Cys Gln Arg Ser
          60                  65                  70

 ccc ggc agc cag ggc gtc agg gac ttc att gag aaa cgc tac gtg gag      472
 Pro Gly Ser Gln Gly Val Arg Asp Phe Ile Glu Lys Arg Tyr Val Glu
      75                  80                  85

 ctg aag aag gcg aat ccc gac cta ccc atc cta atc cgc gaa tgc tcc      520
 Leu Lys Lys Ala Asn Pro Asp Leu Pro Ile Leu Ile Arg Glu Cys Ser
  90                  95                 100                 105

 gat gtg cag ccc aag ctc tgg gcc cgc tac gca ttt ggc caa gag acg      568
 Asp Val Gln Pro Lys Leu Trp Ala Arg Tyr Ala Phe Gly Gln Glu Thr
                 110                 115                 120

 aat gtc cct ttg aac aac ttc agt gct gat cag gta acc aga gcc ctg      616
 Asn Val Pro Leu Asn Asn Phe Ser Ala Asp Gln Val Thr Arg Ala Leu
             125                 130                 135

 gag aac gtt cta agt ggt aaa gcc tga agcct ccactgagga ttaagagcaa      668
 Glu Asn Val Leu Ser Gly Lys Ala 
         140                 145

 cagccccaga gcctgggctc tgctggactt agtataatgt gaaaaaaatg tgttctccta    728

 ttcctcataa agcttgtgct gtaaaaaaaa aaaa                                762




      <210> 6
      <211> 2659
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (270)..(2384)

      <400> 6
 ctggggaggg cgaggcggag gcggcaaaac gggcggtcga gcagaacgtg tagccgcgtc     60

 ccctccagtc cgctccgggc agctgctgat gcaaggaatc ccctgggctc ccgtccactc    120

 cactgctgac cagcccattc gcctgtgctg agtcttcctg caggcctttc cttgcctctg    180

 tgggaccctg tgggggtcca tccggctgga gaagaaaagc ctctcatgct aacgttgcag    240

 accccagagg gtcctgtgtg ggtgtggag  atg gcc aat gag aat cac ggc agc     293
                                  Met Ala Asn Glu Asn His Gly Ser
                                    1               5

 ccc cgg gag gaa gcg tcc ctg ctg agt cac tcc cca ggt acc tcc aat      341
 Pro Arg Glu Glu Ala Ser Leu Leu Ser His Ser Pro Gly Thr Ser Asn
      10                  15                  20

 cag agc cag ccc tgt tct cca aag cca atc cgc ctg gtt cag gac ctc      389
 Gln Ser Gln Pro Cys Ser Pro Lys Pro Ile Arg Leu Val Gln Asp Leu
  25                  30                  35                  40

 cca gag gag ctg gtg cat gca ggc tgg gag aag tgc tgg agc cgg agg      437
 Pro Glu Glu Leu Val His Ala Gly Trp Glu Lys Cys Trp Ser Arg Arg
                  45                  50                  55

 gag aat cgt ccc tac tac ttc aac cga ttc acc aac cag tcc ctg tgg      485
 Glu Asn Arg Pro Tyr Tyr Phe Asn Arg Phe Thr Asn Gln Ser Leu Trp
              60                  65                  70

 gag atg ccc gtg ctg ggg cag cac gat gtg att tcg gac cct ttg ggg      533
 Glu Met Pro Val Leu Gly Gln His Asp Val Ile Ser Asp Pro Leu Gly
          75                  80                  85

 ctg aat gcg acc cca ctg ccc caa gac tca agc ttg gtg gaa act ccc      581
 Leu Asn Ala Thr Pro Leu Pro Gln Asp Ser Ser Leu Val Glu Thr Pro
      90                  95                 100

 ccg gct gag aac aag ccc aga aag cgg cag ctc tcg gaa gag cag cca      629
 Pro Ala Glu Asn Lys Pro Arg Lys Arg Gln Leu Ser Glu Glu Gln Pro
 105                 110                 115                 120

 agc ggc aat ggt gtg aag aag ccc aag att gaa atc cca gtg aca ccc      677
 Ser Gly Asn Gly Val Lys Lys Pro Lys Ile Glu Ile Pro Val Thr Pro
                 125                 130                 135

 aca ggc cag tcg gtg ccc agc tcc ccc agt atc cca gga acc cca acg      725
 Thr Gly Gln Ser Val Pro Ser Ser Pro Ser Ile Pro Gly Thr Pro Thr
             140                 145                 150

 ctg aag atg tgg ggt acg tcc cct gaa gat aaa cag cag gca gct ctc      773
 Leu Lys Met Trp Gly Thr Ser Pro Glu Asp Lys Gln Gln Ala Ala Leu
         155                 160                 165

 cta cga ccc act gag gtc tac tgg gac ctg gac atc cag acc aat gct      821
 Leu Arg Pro Thr Glu Val Tyr Trp Asp Leu Asp Ile Gln Thr Asn Ala
     170                 175                 180

 gtc atc aag cac cgg ggg cct tca gag gtg ctg ccc ccg cat ccc gaa      869
 Val Ile Lys His Arg Gly Pro Ser Glu Val Leu Pro Pro His Pro Glu
 185                 190                 195                 200

 gtg gaa ctg ctc cgc tct cag ctc atc ctg aag ctt cgg cag cac tat      917
 Val Glu Leu Leu Arg Ser Gln Leu Ile Leu Lys Leu Arg Gln His Tyr
                 205                 210                 215

 cgg gag ctg tgc cag cag cga gag ggc att gag cct cca cgg gag tct      965
 Arg Glu Leu Cys Gln Gln Arg Glu Gly Ile Glu Pro Pro Arg Glu Ser
             220                 225                 230

 ttc aac cgc tgg atg ctg gag cgc aag gtg gta gac aaa gga tct gac     1013
 Phe Asn Arg Trp Met Leu Glu Arg Lys Val Val Asp Lys Gly Ser Asp
         235                 240                 245

 ccc ctg ttg ccc agc aac tgt gaa cca gtc gtg tca cct tcc atg ttt     1061
 Pro Leu Leu Pro Ser Asn Cys Glu Pro Val Val Ser Pro Ser Met Phe
     250                 255                 260

 cgt gaa atc atg aac gac att cct atc agg tta tcc cga atc aag ttc     1109
 Arg Glu Ile Met Asn Asp Ile Pro Ile Arg Leu Ser Arg Ile Lys Phe
 265                 270                 275                 280

 cgg gag gaa gcc aag cgc ctg ctc ttt aaa tat gcg gag gcc gcc agg     1157
 Arg Glu Glu Ala Lys Arg Leu Leu Phe Lys Tyr Ala Glu Ala Ala Arg
                 285                 290                 295

 cgg ctc atc gag tcc agg agt gca tcc cct gac agt agg aag gtg gtc     1205
 Arg Leu Ile Glu Ser Arg Ser Ala Ser Pro Asp Ser Arg Lys Val Val
             300                 305                 310

 aaa tgg aat gtg gaa gac acc ttt agc tgg ctt cgg aag gac cac tca     1253
 Lys Trp Asn Val Glu Asp Thr Phe Ser Trp Leu Arg Lys Asp His Ser
         315                 320                 325

 gcc tcc aag gag gac tac atg gat cgc ctg gag cat ctg cgg agg cag     1301
 Ala Ser Lys Glu Asp Tyr Met Asp Arg Leu Glu His Leu Arg Arg Gln
     330                 335                 340

 tgt ggc ccc cac gtc tcg gcc gca gcc aag gac tcc gtg gaa ggc atc     1349
 Cys Gly Pro His Val Ser Ala Ala Ala Lys Asp Ser Val Glu Gly Ile
 345                 350                 355                 360

 tgc agt aag atc tac cac atc tcc ctg gag tac gtc aaa cgg atc cga     1397
 Cys Ser Lys Ile Tyr His Ile Ser Leu Glu Tyr Val Lys Arg Ile Arg
                 365                 370                 375

 gag aag cac ctt gcc atc ctc aag gaa aac aac atc tca gag gag gtg     1445
 Glu Lys His Leu Ala Ile Leu Lys Glu Asn Asn Ile Ser Glu Glu Val
             380                 385                 390

 gag gcc cct gag gtg gag ccc cgc cta gtg tac tgc tac cca gtc cgg     1493
 Glu Ala Pro Glu Val Glu Pro Arg Leu Val Tyr Cys Tyr Pro Val Arg
         395                 400                 405

 ctg gct gtg tct gca ccg ccc atg ccc agc gtg gag atg cac atg gag     1541
 Leu Ala Val Ser Ala Pro Pro Met Pro Ser Val Glu Met His Met Glu
     410                 415                 420

 aac aac gtg gtc tgc atc cgg tat aag gga gag atg gtc aag gtc agc     1589
 Asn Asn Val Val Cys Ile Arg Tyr Lys Gly Glu Met Val Lys Val Ser
 425                 430                 435                 440

 cgc aac tac ttc agc aag ctg tgg ctc ctt tac cgc tac agc tgc att     1637
 Arg Asn Tyr Phe Ser Lys Leu Trp Leu Leu Tyr Arg Tyr Ser Cys Ile
                 445                 450                 455

 gat gac tct gcc ttt gag agg ttc ctg ccc cgg gtc tgg tgt ctt ctc     1685
 Asp Asp Ser Ala Phe Glu Arg Phe Leu Pro Arg Val Trp Cys Leu Leu
             460                 465                 470

 cga cgg tac cag atg atg ttc ggc gtg ggc ctc tac gag ggg act ggc     1733
 Arg Arg Tyr Gln Met Met Phe Gly Val Gly Leu Tyr Glu Gly Thr Gly
         475                 480                 485

 ctg cag gga tcg ctg cct gtg cat gtc ttt gag gcc ctc cac cga ctc     1781
 Leu Gln Gly Ser Leu Pro Val His Val Phe Glu Ala Leu His Arg Leu
     490                 495                 500

 ttt ggc gtc agc ttc gag tgc ttc gcc tca ccc ctc aac tgc tac ttc     1829
 Phe Gly Val Ser Phe Glu Cys Phe Ala Ser Pro Leu Asn Cys Tyr Phe
 505                 510                 515                 520

 cgc cag tac tgt tct gcc ttc ccc gac aca gac ggc tac ttt ggc tcc     1877
 Arg Gln Tyr Cys Ser Ala Phe Pro Asp Thr Asp Gly Tyr Phe Gly Ser
                 525                 530                 535

 cgc ggg ccc tgc cta gac ttt gct cca ctg agt ggt tca ttt gag gcc     1925
 Arg Gly Pro Cys Leu Asp Phe Ala Pro Leu Ser Gly Ser Phe Glu Ala
             540                 545                 550

 aac cct ccc ttc tgc gag gag ctc atg gat gcc atg gtc tct cac ttt     1973
 Asn Pro Pro Phe Cys Glu Glu Leu Met Asp Ala Met Val Ser His Phe
         555                 560                 565

 gag aga ctg ctt gag agc tca ccg gag ccc ctg tcc ttc atc gtg ttc     2021
 Glu Arg Leu Leu Glu Ser Ser Pro Glu Pro Leu Ser Phe Ile Val Phe
     570                 575                 580

 atc cct gag tgg cgg gaa ccc cca aca cca gcg ctc acc cgc atg gag     2069
 Ile Pro Glu Trp Arg Glu Pro Pro Thr Pro Ala Leu Thr Arg Met Glu
 585                 590                 595                 600

 cag agc cgc ttc aaa cgc cac cag ttg atc ctg cct gcc ttt gag cat     2117
 Gln Ser Arg Phe Lys Arg His Gln Leu Ile Leu Pro Ala Phe Glu His
                 605                 610                 615

 gag tac cgc agt ggc tcc cag cac atc tgc aag aag gag gaa atg cac     2165
 Glu Tyr Arg Ser Gly Ser Gln His Ile Cys Lys Lys Glu Glu Met His
             620                 625                 630

 tac aag gcc gtc cac aac acg gct gtg ctc ttc cta cag aac gac cct     2213
 Tyr Lys Ala Val His Asn Thr Ala Val Leu Phe Leu Gln Asn Asp Pro
         635                 640                 645

 ggc ttt gcc aag tgg gcg ccg acg cct gaa cgg ctg cag gag ctg agt     2261
 Gly Phe Ala Lys Trp Ala Pro Thr Pro Glu Arg Leu Gln Glu Leu Ser
     650                 655                 660

 gct gcc tac cgg cag tca ggc cgc agc cac agc tct ggt tct tcc tca     2309
 Ala Ala Tyr Arg Gln Ser Gly Arg Ser His Ser Ser Gly Ser Ser Ser
 665                 670                 675                 680

 tcg tcc tcc tcg gag gcc aag gac cgg gac tcg ggc cgt gag cag ggt     2357
 Ser Ser Ser Ser Glu Ala Lys Asp Arg Asp Ser Gly Arg Glu Gln Gly
                 685                 690                 695

 cct agc cgc gag cct cac ccc act taa catat cctgcgggga ggaggagccc     2409
 Pro Ser Arg Glu Pro His Pro Thr 
             700

 caggggtgct agtctggact gctgggactc gggcccctgg ggcctcagag ggaccccggc   2469

 tgccactgac atatgaagat tatggttctg ccagggctcc cctccctgcc tgtccccaag   2529

 tcctcacctc aaactccctc caagtcccat gtatataggt cctgatgcct tcccaacccc   2589

 gcccctcacc ctgttgccac cttgtttcat ttgtaaaagg aaatacagaa acccccccaa   2649

 aaaaaaaaaa                                                          2659




      <210> 7
      <211> 2781
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (303)..(2378)

      <400> 7
 gcacgagggg gacacaagat ggcggcagcg gcgctgggga gggcgaggcg gaggcggcaa     60

 aacgggcggt cgagcagaac gtgtagccgc gtcccctcca gtccgctccg ggcagctgct    120

 gatgcaagga atcccctggg ctcccgtcca ctccactgct gaccagccca ttcgcctgtg    180

 ctgagtcttc ctgcaggcct ttccttgcct ctgtgggacc ctgtgggggt ccatccggct    240

 ggagaagaaa agcctctcat gctaacgttg cagaccccag agggtcctgt gtgggtgtgg    300

 ag   atg gcc aat gag aat cac ggc agc ccc cgg gag gaa gcg tcc ctg     347
      Met Ala Asn Glu Asn His Gly Ser Pro Arg Glu Glu Ala Ser Leu
        1               5                  10                  15

 ctg agt cac tcc cca ggt acc tcc aat cag agc cag ccc tgt tct cca      395
 Leu Ser His Ser Pro Gly Thr Ser Asn Gln Ser Gln Pro Cys Ser Pro
                  20                  25                  30

 aag cca atc cgc ctg gtt cag gac ctc cca gag gag ctg gtg cat gca      443
 Lys Pro Ile Arg Leu Val Gln Asp Leu Pro Glu Glu Leu Val His Ala
              35                  40                  45

 ggc tgg gag aag tgc tgg agc cgg agg gag aat cgt ccc tac tac ttc      491
 Gly Trp Glu Lys Cys Trp Ser Arg Arg Glu Asn Arg Pro Tyr Tyr Phe
          50                  55                  60

 aac cga ttc acc aac cag tcc ctg tgg gag atg ccc gtg ctg ggg cag      539
 Asn Arg Phe Thr Asn Gln Ser Leu Trp Glu Met Pro Val Leu Gly Gln
      65                  70                  75

 cac gat gtg att tcg gac cct ttg ggg ctg aat gcg acc cca ctg ccc      587
 His Asp Val Ile Ser Asp Pro Leu Gly Leu Asn Ala Thr Pro Leu Pro
  80                  85                  90                  95

 caa gac tca agc ttg gtg gaa act ccc ccg gct gag aac aag ccc aga      635
 Gln Asp Ser Ser Leu Val Glu Thr Pro Pro Ala Glu Asn Lys Pro Arg
                 100                 105                 110

 aag cgg cag ctc tcg gaa gag cag cca agc ggc aat ggt gtg aag aag      683
 Lys Arg Gln Leu Ser Glu Glu Gln Pro Ser Gly Asn Gly Val Lys Lys
             115                 120                 125

 ccc aag att gaa atc cca gtg aca ccc aca ggc cag tcg gtg ccc agc      731
 Pro Lys Ile Glu Ile Pro Val Thr Pro Thr Gly Gln Ser Val Pro Ser
         130                 135                 140

 tcc ccc agt atc cca gga acc cca acg ctg aag atg tgg ggt acg tcc      779
 Ser Pro Ser Ile Pro Gly Thr Pro Thr Leu Lys Met Trp Gly Thr Ser
     145                 150                 155

 cct gaa gat aaa cag cag gca gct ctc cta cga ccc act gag gtc tac      827
 Pro Glu Asp Lys Gln Gln Ala Ala Leu Leu Arg Pro Thr Glu Val Tyr
 160                 165                 170                 175

 tgg gac ctg gac atc cag acc aat gct gtc atc aag cac cgg ggg cct      875
 Trp Asp Leu Asp Ile Gln Thr Asn Ala Val Ile Lys His Arg Gly Pro
                 180                 185                 190

 tca gag gtg ctg ccc ccg cat ccc gaa gtg gaa ctg ctc cgc tct cag      923
 Ser Glu Val Leu Pro Pro His Pro Glu Val Glu Leu Leu Arg Ser Gln
             195                 200                 205

 ctc atc ctg aag ctt cgg cag cac tat cgg gag ctg tgc cag cag cga      971
 Leu Ile Leu Lys Leu Arg Gln His Tyr Arg Glu Leu Cys Gln Gln Arg
         210                 215                 220

 gag ggc att gag cct cca cgg gag tct ttc aac cgc tgg atg ctg gag     1019
 Glu Gly Ile Glu Pro Pro Arg Glu Ser Phe Asn Arg Trp Met Leu Glu
     225                 230                 235

 cgc aag gtg gta gac aaa gga tct gac ccc ctg ttg ccc agc aac tgt     1067
 Arg Lys Val Val Asp Lys Gly Ser Asp Pro Leu Leu Pro Ser Asn Cys
 240                 245                 250                 255

 gaa cca gtc gtg tca cct tcc atg ttt cgt gaa atc atg aac gac att     1115
 Glu Pro Val Val Ser Pro Ser Met Phe Arg Glu Ile Met Asn Asp Ile
                 260                 265                 270

 cct atc agg tta tcc cga atc aag ttc cgg gag gaa gcc aag cgc ctg     1163
 Pro Ile Arg Leu Ser Arg Ile Lys Phe Arg Glu Glu Ala Lys Arg Leu
             275                 280                 285

 ctc ttt aaa tat gcg gag gcc gcc agg cgg ctc atc gag tcc agg agt     1211
 Leu Phe Lys Tyr Ala Glu Ala Ala Arg Arg Leu Ile Glu Ser Arg Ser
         290                 295                 300

 gca tcc cct gac agt agg aag gtg gtc aaa tgg aat gtg gaa gac acc     1259
 Ala Ser Pro Asp Ser Arg Lys Val Val Lys Trp Asn Val Glu Asp Thr
     305                 310                 315

 ttt agc tgg ctt cgg aag gac cac tca gcc tcc aag gag gac tac atg     1307
 Phe Ser Trp Leu Arg Lys Asp His Ser Ala Ser Lys Glu Asp Tyr Met
 320                 325                 330                 335

 gat cgc ctg gag cat ctg cgg agg cag tgt ggc ccc cac gtc tcg gcc     1355
 Asp Arg Leu Glu His Leu Arg Arg Gln Cys Gly Pro His Val Ser Ala
                 340                 345                 350

 gca gcc aag gac tcc gtg gaa ggc atc tgc agt aag atc tac cac atc     1403
 Ala Ala Lys Asp Ser Val Glu Gly Ile Cys Ser Lys Ile Tyr His Ile
             355                 360                 365

 tcc ctg gag tac gtc aaa cgg atc cga gag aag cac ctt gcc atc ctc     1451
 Ser Leu Glu Tyr Val Lys Arg Ile Arg Glu Lys His Leu Ala Ile Leu
         370                 375                 380

 aag gaa aac aac atc tca gag gag gtg gag gcc cct gag gtg gag ccc     1499
 Lys Glu Asn Asn Ile Ser Glu Glu Val Glu Ala Pro Glu Val Glu Pro
     385                 390                 395

 cgc cta gtg tac tgc tac cca gtc cgg ctg gct gtg tct gca ccg ccc     1547
 Arg Leu Val Tyr Cys Tyr Pro Val Arg Leu Ala Val Ser Ala Pro Pro
 400                 405                 410                 415

 atg ccc agc gtg gag atg cac atg gag aac aac gtg gtc tgc atc cgg     1595
 Met Pro Ser Val Glu Met His Met Glu Asn Asn Val Val Cys Ile Arg
                 420                 425                 430

 tat aag gga gag atg gtc aag gtc agc cgc aac tac ttc agc aag ctg     1643
 Tyr Lys Gly Glu Met Val Lys Val Ser Arg Asn Tyr Phe Ser Lys Leu
             435                 440                 445

 tgg ctc ctt tac cgc tac agc tgc att gat gac tct gcc ttt gag agg     1691
 Trp Leu Leu Tyr Arg Tyr Ser Cys Ile Asp Asp Ser Ala Phe Glu Arg
         450                 455                 460

 ttc ctg ccc cgg gtc tgg tgt ctt ctc cga cgg tac cag atg atg ttc     1739
 Phe Leu Pro Arg Val Trp Cys Leu Leu Arg Arg Tyr Gln Met Met Phe
     465                 470                 475

 ggc gtg ggc ctc tac gag ggg act ggc ctg cag gga tcg ctg cct gtg     1787
 Gly Val Gly Leu Tyr Glu Gly Thr Gly Leu Gln Gly Ser Leu Pro Val
 480                 485                 490                 495

 cat gtc ttt gag gcc ctc cac cga ctc ttt ggc gtc agc ttc gag tgc     1835
 His Val Phe Glu Ala Leu His Arg Leu Phe Gly Val Ser Phe Glu Cys
                 500                 505                 510

 ttc gcc tca ccc ctc aac tgc tac ttc cgc cag tac tgt tct gcc ttc     1883
 Phe Ala Ser Pro Leu Asn Cys Tyr Phe Arg Gln Tyr Cys Ser Ala Phe
             515                 520                 525

 ccc gac aca gac ggc tac ttt ggc tcc cgc ggg ccc tgc cta gac ttt     1931
 Pro Asp Thr Asp Gly Tyr Phe Gly Ser Arg Gly Pro Cys Leu Asp Phe
         530                 535                 540

 gct cca ctg agt ggt tca ttt gag gcc aac cct ccc ttc tgc gag gag     1979
 Ala Pro Leu Ser Gly Ser Phe Glu Ala Asn Pro Pro Phe Cys Glu Glu
     545                 550                 555

 ctc atg gat gcc atg gtc tct cac ttt gag aga ctg ctt gag agc tca     2027
 Leu Met Asp Ala Met Val Ser His Phe Glu Arg Leu Leu Glu Ser Ser
 560                 565                 570                 575

 ccg gag ccc ctg tcc ttc atc gtg ttc atc cct gag tgg cgg gaa ccc     2075
 Pro Glu Pro Leu Ser Phe Ile Val Phe Ile Pro Glu Trp Arg Glu Pro
                 580                 585                 590

 cca aca cca gcg ctc acc cgc atg gag cag agc cgc ttc aaa cgc cac     2123
 Pro Thr Pro Ala Leu Thr Arg Met Glu Gln Ser Arg Phe Lys Arg His
             595                 600                 605

 cag ttg atc ctg cct gcc ttt gag cat gag tac cgc agt ggc tcc cag     2171
 Gln Leu Ile Leu Pro Ala Phe Glu His Glu Tyr Arg Ser Gly Ser Gln
         610                 615                 620

 cac atc tgc aag aag tgg gtg cca ggg agg gca ggg gaa gga ggc tgg     2219
 His Ile Cys Lys Lys Trp Val Pro Gly Arg Ala Gly Glu Gly Gly Trp
     625                 630                 635

 gct ggc cag gcc agg ccc agc ccc acc ctg agc cat tgc ctt tgc ccg     2267
 Ala Gly Gln Ala Arg Pro Ser Pro Thr Leu Ser His Cys Leu Cys Pro
 640                 645                 650                 655

 cag gga gga aat gca cta caa ggc cgt cca caa cac ggc tgt gct ctt     2315
 Gln Gly Gly Asn Ala Leu Gln Gly Arg Pro Gln His Gly Cys Ala Leu
                 660                 665                 670

 cct aca gaa cga ccc tgg ctt tgc caa gtg ggg cgc cga cgc ctg aac     2363
 Pro Thr Glu Arg Pro Trp Leu Cys Gln Val Gly Arg Arg Arg Leu Asn
             675                 680                 685

 ggc tgc agg agc tga gtgctgccta ccggcagtca ggccgcagcc acagctctgg     2418
 Gly Cys Arg Ser 
         690

 ttcttcctca tcgtcctcct cggaggccaa ggaccgggac tcgggccgtg agcagggtcc   2478

 tagccgcgag cctcacccca cttaacatat cctgcgggga ggaggagccc caggggtgct   2538

 agtctggact gctgggactc gggcccctgg ggcctcagag ggaccccggc tgccactgac   2598

 atatgaagat tatggttctg ccagggctcc cctccctgcc tgtccccaag tcctcacctc   2658

 aaactccctc caagtcccat gtatataggt cctgatgcct tcccaacccc gcccctcacc   2718

 ctgttgccac cttgtttcat ttgtaaaagg aaatacagaa acccccccaa gaaaaaaaaa   2778

 aaa                                                                 2781




      <210> 8
      <211> 1597
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(1533)

      <400> 8
 gtcacaccaa aatatgaaat atgaatcgga atgtgcttct gggaagatag gtggctgagc     60

 cgaggttgtg gagagccctg acgttaactt gaagaatctg cc   atg tcc acg cag     114
                                                  Met Ser Thr Gln
                                                    1

 aga ctt cgg aat gaa gac tac cac gac tac agc tcc acg gac gtg agc      162
 Arg Leu Arg Asn Glu Asp Tyr His Asp Tyr Ser Ser Thr Asp Val Ser
   5                  10                  15                  20

 cct gag gag agc ccg tcg gaa ggc ctc aac aac ctc tcc tcc ccg ggc      210
 Pro Glu Glu Ser Pro Ser Glu Gly Leu Asn Asn Leu Ser Ser Pro Gly
                  25                  30                  35

 tcc tac cag cgc ttt ggt caa agc aat agc aca aca tgg ttc cag acc      258
 Ser Tyr Gln Arg Phe Gly Gln Ser Asn Ser Thr Thr Trp Phe Gln Thr
              40                  45                  50

 ttg atc cac ctg tta aaa ggc aac att ggc aca gga ctc ctg gga ctc      306
 Leu Ile His Leu Leu Lys Gly Asn Ile Gly Thr Gly Leu Leu Gly Leu
          55                  60                  65

 cct ctg gcg gtg aaa aat gca ggc atc gtg atg ggt ccc atc agc ctg      354
 Pro Leu Ala Val Lys Asn Ala Gly Ile Val Met Gly Pro Ile Ser Leu
      70                  75                  80

 ctg atc ata ggc atc gtg gcc gtg cac tgc atg ggt atc ctg gtg aaa      402
 Leu Ile Ile Gly Ile Val Ala Val His Cys Met Gly Ile Leu Val Lys
  85                  90                  95                 100

 tgt gct cac cac ttc tgc cgc agg ctg aat aaa tcc ttt gtg gat tat      450
 Cys Ala His His Phe Cys Arg Arg Leu Asn Lys Ser Phe Val Asp Tyr
                 105                 110                 115

 ggt gat act gtg atg tat gga cta gaa tcc agc ccc tgc tcc tgg ctc      498
 Gly Asp Thr Val Met Tyr Gly Leu Glu Ser Ser Pro Cys Ser Trp Leu
             120                 125                 130

 cgg aac cac gca cac tgg gga aga cgt gtt gtg gac ttc ttc ctg att      546
 Arg Asn His Ala His Trp Gly Arg Arg Val Val Asp Phe Phe Leu Ile
         135                 140                 145

 gtc acc cag ctg gga ttc tgc tgt gtc tat ttt gtg ttt ctg gct gac      594
 Val Thr Gln Leu Gly Phe Cys Cys Val Tyr Phe Val Phe Leu Ala Asp
     150                 155                 160

 aac ttt aaa cag gtg ata gaa gcg gcc aat ggg acc acc aat aac tgc      642
 Asn Phe Lys Gln Val Ile Glu Ala Ala Asn Gly Thr Thr Asn Asn Cys
 165                 170                 175                 180

 cac aac aat gag acg gtg att ctg acg cct acc atg gac tcg cga ctc      690
 His Asn Asn Glu Thr Val Ile Leu Thr Pro Thr Met Asp Ser Arg Leu
                 185                 190                 195

 tac atg ctc tcc ttc ctg ccc ttc ctg gtg ctg ctg gtt ttc atc agg      738
 Tyr Met Leu Ser Phe Leu Pro Phe Leu Val Leu Leu Val Phe Ile Arg
             200                 205                 210

 aac ctc cga gcc ctg tcc atc ttc tcc ctg ttg gcc aac atc acc atg      786
 Asn Leu Arg Ala Leu Ser Ile Phe Ser Leu Leu Ala Asn Ile Thr Met
         215                 220                 225

 ctg gtc agc ttg gtc atg atc tac cag ttc att gtt cag agg atc cca      834
 Leu Val Ser Leu Val Met Ile Tyr Gln Phe Ile Val Gln Arg Ile Pro
     230                 235                 240

 gac ccc agc cac ctc ccc ttg gtg gcc cct tgg aag acc tac cct ctc      882
 Asp Pro Ser His Leu Pro Leu Val Ala Pro Trp Lys Thr Tyr Pro Leu
 245                 250                 255                 260

 ttc ttt ggc aca gcg att ttt tca ttt gaa ggc att gga atg gtt ctg      930
 Phe Phe Gly Thr Ala Ile Phe Ser Phe Glu Gly Ile Gly Met Val Leu
                 265                 270                 275

 ccc ctg gaa aac aaa atg aag gat cct cgg aag ttc cca ctc atc ctg      978
 Pro Leu Glu Asn Lys Met Lys Asp Pro Arg Lys Phe Pro Leu Ile Leu
             280                 285                 290

 tac ctg ggc atg gtc atc gtc acc atc ctc tac atc agc ctg ggg tgt     1026
 Tyr Leu Gly Met Val Ile Val Thr Ile Leu Tyr Ile Ser Leu Gly Cys
         295                 300                 305

 ctg ggg tac ctg caa ttt gga gct aat atc caa ggc agc ata acc ctc     1074
 Leu Gly Tyr Leu Gln Phe Gly Ala Asn Ile Gln Gly Ser Ile Thr Leu
     310                 315                 320

 aac ctg ccc aac tgc tgg ttg tac cag tca gtt aag ctg ctg tac tcc     1122
 Asn Leu Pro Asn Cys Trp Leu Tyr Gln Ser Val Lys Leu Leu Tyr Ser
 325                 330                 335                 340

 atc ggg atc ttt ttc acc tac gca ctc cag ttc tac gtc ccg gct gag     1170
 Ile Gly Ile Phe Phe Thr Tyr Ala Leu Gln Phe Tyr Val Pro Ala Glu
                 345                 350                 355

 atc atc atc ccc ttc ttt gtg tcc cga gcg ccc gag cac tgt gag tta     1218
 Ile Ile Ile Pro Phe Phe Val Ser Arg Ala Pro Glu His Cys Glu Leu
             360                 365                 370

 gtg gtg gac ctg ttt gtg cgc aca gtg ctg gtc tgc ctg aca tgc atc     1266
 Val Val Asp Leu Phe Val Arg Thr Val Leu Val Cys Leu Thr Cys Ile
         375                 380                 385

 ttg gcc atc ctc atc ccc cgc ctg gac ctg gtc atc tcc ctg gtg ggc     1314
 Leu Ala Ile Leu Ile Pro Arg Leu Asp Leu Val Ile Ser Leu Val Gly
     390                 395                 400

 tcc gtg agc agc agc gcc ctg gcc ctc atc atc cca ccg ctc ctg gag     1362
 Ser Val Ser Ser Ser Ala Leu Ala Leu Ile Ile Pro Pro Leu Leu Glu
 405                 410                 415                 420

 gtc acc acc ttc tac tca gag ggc atg agc ccc ctc acc atc ttt aag     1410
 Val Thr Thr Phe Tyr Ser Glu Gly Met Ser Pro Leu Thr Ile Phe Lys
                 425                 430                 435

 gac gcc ctg atc agc atc ctg ggc ttc gtg ggc ttt gtg gtg ggg acc     1458
 Asp Ala Leu Ile Ser Ile Leu Gly Phe Val Gly Phe Val Val Gly Thr
             440                 445                 450

 tat gag gct ctc tat gag ctg atc cag cca agc aat gct ccc atc ttc     1506
 Tyr Glu Ala Leu Tyr Glu Leu Ile Gln Pro Ser Asn Ala Pro Ile Phe
         455                 460                 465

 atc aat tcc acc tgt gcc ttc ata tag ggatc tgggttcgtc tctgcagctg     1558
 Ile Asn Ser Thr Cys Ala Phe Ile 
     470                 475

 cctacccctg ccccatgtgt cccccgttac ctgtcctca                          1597




      <210> 9
      <211> 945
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(891)

      <400> 9
 agaggactcc aagcgccatg gccgctgccg cccgagcccg ggtcgcgtac ttgctgaggc     60

 aactgcaacg cgcagccccc tggactttca ccttctggga aaacaacaga ttatgccttt    120

 gag  atg gct gtt tca aat att aga tat gga gca gca gtt aca aag gaa     168
      Met Ala Val Ser Asn Ile Arg Tyr Gly Ala Ala Val Thr Lys Glu
        1               5                  10                  15

 gta gga atg gac cta aaa aac atg ggt gct aaa aat gtg tgc ttg atg      216
 Val Gly Met Asp Leu Lys Asn Met Gly Ala Lys Asn Val Cys Leu Met
                  20                  25                  30

 aca gac aag aac ctc tcc aag ctc cct cct gtg caa gta gct atg gat      264
 Thr Asp Lys Asn Leu Ser Lys Leu Pro Pro Val Gln Val Ala Met Asp
              35                  40                  45

 tcc cta gtg aag aat ggc atc ccc ttt acg gtt tat gat aat gtg aga      312
 Ser Leu Val Lys Asn Gly Ile Pro Phe Thr Val Tyr Asp Asn Val Arg
          50                  55                  60

 gtg gaa cca acg gat tca agc ttc atg gaa gct att gag ttt gcc caa      360
 Val Glu Pro Thr Asp Ser Ser Phe Met Glu Ala Ile Glu Phe Ala Gln
      65                  70                  75

 aag gga gct ttt gat gcc tat gtt gct gtc ggt ggt ggc tct acc atg      408
 Lys Gly Ala Phe Asp Ala Tyr Val Ala Val Gly Gly Gly Ser Thr Met
  80                  85                  90                  95

 gac acc tgt aag gct gct aat ctg tat gca tcc agc cct cat tct gat      456
 Asp Thr Cys Lys Ala Ala Asn Leu Tyr Ala Ser Ser Pro His Ser Asp
                 100                 105                 110

 ttc cta gat tat gtc agt gcc ccc att ggc aag gga aag cct gtg tct      504
 Phe Leu Asp Tyr Val Ser Ala Pro Ile Gly Lys Gly Lys Pro Val Ser
             115                 120                 125

 gtg cct ctt aag cct ctg att gca gtg cca act acc tca gga acc ggg      552
 Val Pro Leu Lys Pro Leu Ile Ala Val Pro Thr Thr Ser Gly Thr Gly
         130                 135                 140

 agt gaa act act ggg gtt gcc att ttt gac tat gaa cac ttg aaa gta      600
 Ser Glu Thr Thr Gly Val Ala Ile Phe Asp Tyr Glu His Leu Lys Val
     145                 150                 155

 aaa att ggc atc act tcg aga gcc atc aaa ccc aca ctg gga ctg att      648
 Lys Ile Gly Ile Thr Ser Arg Ala Ile Lys Pro Thr Leu Gly Leu Ile
 160                 165                 170                 175

 gat cct ctg cac acc ctc cac atg cct gcc cga gtg gtc gcc aac agt      696
 Asp Pro Leu His Thr Leu His Met Pro Ala Arg Val Val Ala Asn Ser
                 180                 185                 190

 ggc ttt gat gtg ctt tgc cat gcc ctg gag tca tac acc acc ctg ccc      744
 Gly Phe Asp Val Leu Cys His Ala Leu Glu Ser Tyr Thr Thr Leu Pro
             195                 200                 205

 tac cac ctg cgg agc ccc tgc cct tca aat ccc atc aca cgg cct gcg      792
 Tyr His Leu Arg Ser Pro Cys Pro Ser Asn Pro Ile Thr Arg Pro Ala
         210                 215                 220

 tac cag ggc agc aac cca atc agt gac att tgg gct atc cac gcg ctg      840
 Tyr Gln Gly Ser Asn Pro Ile Ser Asp Ile Trp Ala Ile His Ala Leu
     225                 230                 235

 cgg atc gtg gct aag tat ctg aag agg gcc gtc aac agc act gac aaa      888
 Arg Ile Val Ala Lys Tyr Leu Lys Arg Ala Val Asn Ser Thr Asp Lys
 240                 245                 250                 255

 tga agaa gaagaatgag tctcagggca ccttcctgga gtggccctcg ccatccaggg      945
 






      <210> 10
      <211> 2256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(947)

      <400> 10
 gagcgacccg aggagggaag aggactccaa gcgcc   atg gcc gct gcc gcc cga      53
                                          Met Ala Ala Ala Ala Arg
                                            1               5

 gcc cgg gtc gcg tac ttg ctg agg caa ctg caa cgc gca gcg tgc cag      101
 Ala Arg Val Ala Tyr Leu Leu Arg Gln Leu Gln Arg Ala Ala Cys Gln
              10                  15                  20

 tgc cca act cat tct cat act tac tcc caa gcc cct gga ctt tca cct      149
 Cys Pro Thr His Ser His Thr Tyr Ser Gln Ala Pro Gly Leu Ser Pro
          25                  30                  35

 tct ggg aaa aca aca gat tat gcc ttt gag atg gct gtt tca aat att      197
 Ser Gly Lys Thr Thr Asp Tyr Ala Phe Glu Met Ala Val Ser Asn Ile
      40                  45                  50

 aga tat gga gca gca gtt aca aag gaa gta gga atg gac cta aaa aac      245
 Arg Tyr Gly Ala Ala Val Thr Lys Glu Val Gly Met Asp Leu Lys Asn
  55                  60                  65                  70

 atg ggt gct aaa aat gtg tgc ttg atg aca gac aag aac ctc tcc aag      293
 Met Gly Ala Lys Asn Val Cys Leu Met Thr Asp Lys Asn Leu Ser Lys
                  75                  80                  85

 ctc cct cct gtg caa gta gct atg gat tcc cta gtg aag aat ggc atc      341
 Leu Pro Pro Val Gln Val Ala Met Asp Ser Leu Val Lys Asn Gly Ile
              90                  95                 100

 ccc ttt acg gtt tat gat aat gtg aga gtg gaa cca acg gat tca agc      389
 Pro Phe Thr Val Tyr Asp Asn Val Arg Val Glu Pro Thr Asp Ser Ser
         105                 110                 115

 ttc atg gaa gct att gag ttt gcc caa aag gga gct ttt gat gcc tat      437
 Phe Met Glu Ala Ile Glu Phe Ala Gln Lys Gly Ala Phe Asp Ala Tyr
     120                 125                 130

 gtt gct gtc ggt ggt ggc tct acc atg gac acc tgt aag gct gct aat      485
 Val Ala Val Gly Gly Gly Ser Thr Met Asp Thr Cys Lys Ala Ala Asn
 135                 140                 145                 150

 ctg tat gca tcc agc cct cat tct gat ttc cta gat tat gtc agt gcc      533
 Leu Tyr Ala Ser Ser Pro His Ser Asp Phe Leu Asp Tyr Val Ser Ala
                 155                 160                 165

 ccc att ggc aag gga aag cct gtg tct gtg cct ctt aag cct ctg att      581
 Pro Ile Gly Lys Gly Lys Pro Val Ser Val Pro Leu Lys Pro Leu Ile
             170                 175                 180

 gca gtg cca act acc tca gga acc ggg agt gaa act act ggg gtt gcc      629
 Ala Val Pro Thr Thr Ser Gly Thr Gly Ser Glu Thr Thr Gly Val Ala
         185                 190                 195

 att ttt gac tat gaa cac ttg aaa gta aaa att ggc atc act tcg aga      677
 Ile Phe Asp Tyr Glu His Leu Lys Val Lys Ile Gly Ile Thr Ser Arg
     200                 205                 210

 gcc atc aaa ccc aca ctg gga ctg att gat cct ctg cac acc ctc cac      725
 Ala Ile Lys Pro Thr Leu Gly Leu Ile Asp Pro Leu His Thr Leu His
 215                 220                 225                 230

 atg cct gcc cga gtg gtc gcc aac agt ggc ttt gat gtg ctt tgc cat      773
 Met Pro Ala Arg Val Val Ala Asn Ser Gly Phe Asp Val Leu Cys His
                 235                 240                 245

 gcc ctg gag tca tac acc acc ctg ccc tac cac ctg cgg agc ccc tgc      821
 Ala Leu Glu Ser Tyr Thr Thr Leu Pro Tyr His Leu Arg Ser Pro Cys
             250                 255                 260

 cct tca aat ccc atc aca cgg cct gcg tac cag ggc agc aac cca atc      869
 Pro Ser Asn Pro Ile Thr Arg Pro Ala Tyr Gln Gly Ser Asn Pro Ile
         265                 270                 275

 agt gac att tgg gct atc cac gcg ctg cgg atc gtg gct aag tat ctg      917
 Ser Asp Ile Trp Ala Ile His Ala Leu Arg Ile Val Ala Lys Tyr Leu
     280                 285                 290

 aag agg gcc gtc aac agc act gac aaa tga a gaagaagaat gagtctcagg      968
 Lys Arg Ala Val Asn Ser Thr Asp Lys 
 295                 300

 gcaccttcct ggagtggccc tcgccatcca gggaccagcg cgttgcctcc cccggcgctt   1028

 ttacatcaca tgagcagctg acagcgtatt tattatgcct ttgctgaaac agttgatgag   1088

 aaatatgttt cccttcagtt ttcatttaga agacaaggcg tcgtttgaat aacttgcctg   1148

 atttttcttc ctaccgagta gcatttcttt ttttttcacc atatctttcc ctaaggcagc   1208

 tccttattct gtaggaattg ccaatgttga tgtgttattg ttaggtattt atatcattca   1268

 cagggctgtc agaaatcccg atgatcttga agcaaggtct catatgcact tggcaagtgc   1328

 ttttgctggc atcggctttg gaaatgctgg tgttcatctg tgccatggaa tgtcttaccc   1388

 aatttcaggt ttagtgaaga tgtataaagc aaaggattac aatgtggatc acccactggt   1448

 gccccatggc ctttctgtgg tgctcacgtc cccagcggtg ttcactttca cggcccagat   1508

 gtttccagag cgacacctgg agatggcaga aatactggga gccgacaccc gcactgccag   1568

 gatccaagat gcagggctgg tgttggcaga cacgctccgg aaattcttat tcgatctgga   1628

 tgttgatgat ggcctagcag ctgttggtta ctccaaagct gatatccccg cactagtgaa   1688

 aggaacgctg ccccaggaaa gggtcaccaa gcttgcaccc cgtccccagt cagaagagga   1748

 tctggctgct ctgtttgaag cttcaatgaa actgtattaa ttgtcatttt aactgaaaga   1808

 attaccgctg gccattgtag tgctgagagc aagagctgat ctagctaggg ctttgtcttt   1868

 tcatctttgt gcataactta cctgttacca gtataggtgg gatatacatt tatcttgcag   1928

 gaaattcccc aaagctcaga gtccagttcc ttccataaaa caggctggac aaatgaccac   1988

 tatgttagac ccccaggctc gacttcaggg gtcagtgttc ctgtcccaaa ccccacacag   2048

 aatactctgc ctctgcttca tgtagcaaat gagcaaaaac tcagtatcta tcaaaagtgt   2108

 aaattatatt tcctatgcct agtaattcac ttcatgtcta aaaatttatc tgatagaaac   2168

 actagcacca gtacatacag aagcatggca aggatgtttc tggcagcact tttctaataa   2228

 taaaagattt gaaacaaaaa aaaaaaaa                                      2256




      <210> 11
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(1338)

      <400> 11
 gcacgagcta aacctgaaga aagtttagag cctggggcta taaactacct gagtctttcc     60

 aaacgacaag ccaagaagac ctgttgaaag tttcctctta agtttcgtgg agagagactc    120

 aggtatagaa atatccttac tgccacctga cctgaagcag aagaaatcac agacagcttc    180

 cagaccaggc ccaac atg tgt agc acc agt ggg tgt gac ctg gaa gaa atc     231
                  Met Cys Ser Thr Ser Gly Cys Asp Leu Glu Glu Ile
                    1               5                  10

 ccc cta gat gat gat gac cta aac acc ata gaa ttc aaa atc ctc gcc      279
 Pro Leu Asp Asp Asp Asp Leu Asn Thr Ile Glu Phe Lys Ile Leu Ala
          15                  20                  25

 tac tac acc aga cat cat gtc ttc aag agc acc cct gct ctc ttc tca      327
 Tyr Tyr Thr Arg His His Val Phe Lys Ser Thr Pro Ala Leu Phe Ser
      30                  35                  40

 cca aag ctg ctg aga aca aga agt ttg tcc cag agg ggc ctg ggg aat      375
 Pro Lys Leu Leu Arg Thr Arg Ser Leu Ser Gln Arg Gly Leu Gly Asn
  45                  50                  55                  60

 tgt tca gca aat gag tca tgg aca gag gtg tca tgg cct tgc aga aat      423
 Cys Ser Ala Asn Glu Ser Trp Thr Glu Val Ser Trp Pro Cys Arg Asn
                  65                  70                  75

 tcc caa tcc agt gag aag gcc ata aac ctt ggc aag aaa aag tct tct      471
 Ser Gln Ser Ser Glu Lys Ala Ile Asn Leu Gly Lys Lys Lys Ser Ser
              80                  85                  90

 tgg aaa gca ttc ttt gga gta gtg gag aag gaa gat tcg cag agc acg      519
 Trp Lys Ala Phe Phe Gly Val Val Glu Lys Glu Asp Ser Gln Ser Thr
          95                 100                 105

 cct gcc aag gtc tct gct cag ggt caa agg acg ttg gaa tac caa gat      567
 Pro Ala Lys Val Ser Ala Gln Gly Gln Arg Thr Leu Glu Tyr Gln Asp
     110                 115                 120

 tcg cac agc cag cag tgg tcc agg tgt ctt tct aac gtg gag cag tgc      615
 Ser His Ser Gln Gln Trp Ser Arg Cys Leu Ser Asn Val Glu Gln Cys
 125                 130                 135                 140

 ttg gag cat gaa gtg ctg tac aaa gcc cag aag tgc cct agg agt ttg      663
 Leu Glu His Glu Val Leu Tyr Lys Ala Gln Lys Cys Pro Arg Ser Leu
                 145                 150                 155

 agc aca cca acc ttc tgt cca aaa cgc cac tcc att act gtc ttc aag      711
 Ser Thr Pro Thr Phe Cys Pro Lys Arg His Ser Ile Thr Val Phe Lys
             160                 165                 170

 tcc tgt gaa tta cct aat gtt agt ctt caa atg tta cat gct gtg gac      759
 Ser Cys Glu Leu Pro Asn Val Ser Leu Gln Met Leu His Ala Val Asp
         175                 180                 185

 ccc aaa gtc att tcc att gcc aac cga gta gct gaa att gtt tac tcc      807
 Pro Lys Val Ile Ser Ile Ala Asn Arg Val Ala Glu Ile Val Tyr Ser
     190                 195                 200

 tgg cca cca cca caa gcg acc cag gca gga ggc ttc aag tcc aaa gag      855
 Trp Pro Pro Pro Gln Ala Thr Gln Ala Gly Gly Phe Lys Ser Lys Glu
 205                 210                 215                 220

 att ttt gta act gag ggt ctc tcc ttc cag ctc caa ggc cac gtg cct      903
 Ile Phe Val Thr Glu Gly Leu Ser Phe Gln Leu Gln Gly His Val Pro
                 225                 230                 235

 gta gct tca agt tct aag aaa gat gaa gaa gaa caa ata cta gcc aaa      951
 Val Ala Ser Ser Ser Lys Lys Asp Glu Glu Glu Gln Ile Leu Ala Lys
             240                 245                 250

 att gtt gag ctg ctg aaa tat tca gga gat cag ttg gaa aga aag ctg      999
 Ile Val Glu Leu Leu Lys Tyr Ser Gly Asp Gln Leu Glu Arg Lys Leu
         255                 260                 265

 aag aaa gat aag gct ttg atg ggc cac ttc cag gat ggg ctg tcc tac     1047
 Lys Lys Asp Lys Ala Leu Met Gly His Phe Gln Asp Gly Leu Ser Tyr
     270                 275                 280

 tct gtt ttc aag acc atc aca gac cag gtc cta atg ggt gtg gac ccc     1095
 Ser Val Phe Lys Thr Ile Thr Asp Gln Val Leu Met Gly Val Asp Pro
 285                 290                 295                 300

 agg gga gaa tca gag gtc aaa gct cag ggc ttt aag gct gcc ctt gta     1143
 Arg Gly Glu Ser Glu Val Lys Ala Gln Gly Phe Lys Ala Ala Leu Val
                 305                 310                 315

 ata gac gtc acg gcc aag ctc aca gct att gac aac cac ccg atg aac     1191
 Ile Asp Val Thr Ala Lys Leu Thr Ala Ile Asp Asn His Pro Met Asn
             320                 325                 330

 agg gtc ctg ggc ttt ggc acc aag tac ctg aaa gag aac ttc tcg cca     1239
 Arg Val Leu Gly Phe Gly Thr Lys Tyr Leu Lys Glu Asn Phe Ser Pro
         335                 340                 345

 tgg atc cag cag cac ggt gga tgg gta agc gta tcc tat tta caa att     1287
 Trp Ile Gln Gln His Gly Gly Trp Val Ser Val Ser Tyr Leu Gln Ile
     350                 355                 360

 ttc tca gaa ctc aga aga gat ggg atg gat ttt ttt ttt ttt ttt aaa     1335
 Phe Ser Glu Leu Arg Arg Asp Gly Met Asp Phe Phe Phe Phe Phe Lys
 365                 370                 375                 380

 tga aggg aacacatcta tgaagcagtt ctcatgagtt taggacactt gagtggccag     1392
 






      <210> 12
      <211> 998
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (94)..(987)

      <400> 12
 tgtcgttgtt ctgaggaaga atcctccaat aatctaaccc agttccagac tgtagaggcc     60

 caattgaaac agtggcttgt ggaaaaagaa ctt atg gtc agt gtt ctt ggg ccc     114
                                      Met Val Ser Val Leu Gly Pro
                                        1               5

 ttg tca att gac cca aat atg cta aac aca caa agg cag cag gtg cag      162
 Leu Ser Ile Asp Pro Asn Met Leu Asn Thr Gln Arg Gln Gln Val Gln
          10                  15                  20

 att ttg ctg caa gaa ttc gcc act cgg aaa cct caa tat gaa cag ctg      210
 Ile Leu Leu Gln Glu Phe Ala Thr Arg Lys Pro Gln Tyr Glu Gln Leu
      25                  30                  35

 aca gca gct ggt cag ggc att ctg agc agg cct gga gaa gac cct tct      258
 Thr Ala Ala Gly Gln Gly Ile Leu Ser Arg Pro Gly Glu Asp Pro Ser
  40                  45                  50                  55

 tta cat ggg att gtg aaa gag caa ctg gca gct gtg acc caa aaa tgg      306
 Leu His Gly Ile Val Lys Glu Gln Leu Ala Ala Val Thr Gln Lys Trp
                  60                  65                  70

 gat agc cta aca ggg caa ttg agt gac aga tgt gac tgg att gac caa      354
 Asp Ser Leu Thr Gly Gln Leu Ser Asp Arg Cys Asp Trp Ile Asp Gln
              75                  80                  85

 gcc att gtt aaa agc aca cag tat caa agc ctg ctg aga agc ctt tct      402
 Ala Ile Val Lys Ser Thr Gln Tyr Gln Ser Leu Leu Arg Ser Leu Ser
          90                  95                 100

 gat aaa ctg agt gac ttg gat aat aaa ctc agc agc agt ctg gct gtg      450
 Asp Lys Leu Ser Asp Leu Asp Asn Lys Leu Ser Ser Ser Leu Ala Val
     105                 110                 115

 agc acg cac cct gat gct atg aac caa cag ttg gaa aca gcc caa aaa      498
 Ser Thr His Pro Asp Ala Met Asn Gln Gln Leu Glu Thr Ala Gln Lys
 120                 125                 130                 135

 atg aag cag gag ata cag cag gaa aag aag cag ata aaa gtg gcc cag      546
 Met Lys Gln Glu Ile Gln Gln Glu Lys Lys Gln Ile Lys Val Ala Gln
                 140                 145                 150

 gca ctc tgt gag gat ttg tca gca ctg gtt aaa gaa gag tac ttg aaa      594
 Ala Leu Cys Glu Asp Leu Ser Ala Leu Val Lys Glu Glu Tyr Leu Lys
             155                 160                 165

 gca gaa ctt agt agg caa cta gaa ggc atc tta aaa tca ttt aag gat      642
 Ala Glu Leu Ser Arg Gln Leu Glu Gly Ile Leu Lys Ser Phe Lys Asp
         170                 175                 180

 gtt gaa cag aaa gca gag aat cat gtc cag cac ctt cag tcg gcc tgt      690
 Val Glu Gln Lys Ala Glu Asn His Val Gln His Leu Gln Ser Ala Cys
     185                 190                 195

 gca agc tct cat caa ttt cag caa atg tct aga gat ttt cag gct tgg      738
 Ala Ser Ser His Gln Phe Gln Gln Met Ser Arg Asp Phe Gln Ala Trp
 200                 205                 210                 215

 ctg gat aca aag aaa gaa gag caa aac aaa tct cat cca ata tct gcc      786
 Leu Asp Thr Lys Lys Glu Glu Gln Asn Lys Ser His Pro Ile Ser Ala
                 220                 225                 230

 aaa ctc gat gtc ttg gag tca tta att aaa gat cat aaa gac ttt agt      834
 Lys Leu Asp Val Leu Glu Ser Leu Ile Lys Asp His Lys Asp Phe Ser
             235                 240                 245

 aaa act ttg acc gct cag tct cat atg tat gaa aaa acc att gca gaa      882
 Lys Thr Leu Thr Ala Gln Ser His Met Tyr Glu Lys Thr Ile Ala Glu
         250                 255                 260

 ggt gaa aat ctg tta tta aaa aca caa ggg tct gag aag gca gcc tta      930
 Gly Glu Asn Leu Leu Leu Lys Thr Gln Gly Ser Glu Lys Ala Ala Leu
     265                 270                 275

 cag tta cag ctt aat aca att aaa acc aat tgg gat aca ttt aat aag      978
 Gln Leu Gln Leu Asn Thr Ile Lys Thr Asn Trp Asp Thr Phe Asn Lys
 280                 285                 290                 295

 cag gtg tga aaaaaaaaaa a                                             998
 Gln Val 






      <210> 13
      <211> 585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(531)

      <400> 13
  atg aag gcc ttg ggc aca caa caa gag tac aag gtg gtg tgt cac tgc      48
  Met Lys Ala Leu Gly Thr Gln Gln Glu Tyr Lys Val Val Cys His Cys
    1               5                  10                  15

 ctg ccc acc ccc aaa tgc cac aca ctg ccc ctc tac cac atg caa atc       96
 Leu Pro Thr Pro Lys Cys His Thr Leu Pro Leu Tyr His Met Gln Ile
              20                  25                  30

 ttt gcg cct aat cat gta gtc gcc aag ttc cac ttc tgg tac ttc cta      144
 Phe Ala Pro Asn His Val Val Ala Lys Phe His Phe Trp Tyr Phe Leu
          35                  40                  45

 tct caa tta aag aag atg aag aag tct tca ggg gag att gtc tac tgt      192
 Ser Gln Leu Lys Lys Met Lys Lys Ser Ser Gly Glu Ile Val Tyr Cys
      50                  55                  60

 ggg cag gtg ttt gag aag tcc ccc ctg cgg gtg aag aac ttc ggg atc      240
 Gly Gln Val Phe Glu Lys Ser Pro Leu Arg Val Lys Asn Phe Gly Ile
  65                  70                  75                  80

 tgg ctg cgc tat gac tcc cgg agc ggc acc cac aac atg tac cgg gaa      288
 Trp Leu Arg Tyr Asp Ser Arg Ser Gly Thr His Asn Met Tyr Arg Glu
                  85                  90                  95

 tac cgg gac ctg acc acc gca ggc gct gtc acc cag tgc tac cga gac      336
 Tyr Arg Asp Leu Thr Thr Ala Gly Ala Val Thr Gln Cys Tyr Arg Asp
             100                 105                 110

 atg ggt gcc cgg cac cgc gcc cga gcc cac tcc att cag atc atg aag      384
 Met Gly Ala Arg His Arg Ala Arg Ala His Ser Ile Gln Ile Met Lys
         115                 120                 125

 gtg gag gag atc gcg gcc agc aag tgc cgc cgg ccg gct gtc aag cag      432
 Val Glu Glu Ile Ala Ala Ser Lys Cys Arg Arg Pro Ala Val Lys Gln
     130                 135                 140

 ttc cac gac tcc aag atc aag ttc ccg ctg ccc cac cgg gtc ctg cgc      480
 Phe His Asp Ser Lys Ile Lys Phe Pro Leu Pro His Arg Val Leu Arg
 145                 150                 155                 160

 cgt cag cac aag cca cgc ttc acc acc aag agg ccc aac acc ttc ttc      528
 Arg Gln His Lys Pro Arg Phe Thr Thr Lys Arg Pro Asn Thr Phe Phe
                 165                 170                 175

 tag gtgc agggccctcg tccgggtgtg ctcaaataaa ctcaggaacg ccccggtgaa      585
 






      <210> 14
      <211> 880
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(555)

      <400> 14
  atg agt aaa gct gta aga aaa aca gtg gag ccg aaa cga ctc ccc aac      48
  Met Ser Lys Ala Val Arg Lys Thr Val Glu Pro Lys Arg Leu Pro Asn
    1               5                  10                  15

 tta act ccc cat aag ctc att gag gac aca gac ttt gtt ctc ttc acc       96
 Leu Thr Pro His Lys Leu Ile Glu Asp Thr Asp Phe Val Leu Phe Thr
              20                  25                  30

 act gtt tcc cca gca ctt cga aca cta cct ggc act tgt atc agt tct      144
 Thr Val Ser Pro Ala Leu Arg Thr Leu Pro Gly Thr Cys Ile Ser Ser
          35                  40                  45

 ccc ttt cca act tgg acg cgg cag aac ggc tcc tgc aaa gaa ggg tgg      192
 Pro Phe Pro Thr Trp Thr Arg Gln Asn Gly Ser Cys Lys Glu Gly Trp
      50                  55                  60

 cga gaa gca aag ggt cat tct gcc atc aat gag gtg gtg atc caa gaa      240
 Arg Glu Ala Lys Gly His Ser Ala Ile Asn Glu Val Val Ile Gln Glu
  65                  70                  75                  80

 tac acc atc aac att cac aag cgc atc cat gga gtg cgc ttc aag aag      288
 Tyr Thr Ile Asn Ile His Lys Arg Ile His Gly Val Arg Phe Lys Lys
                  85                  90                  95

 cgt gcc cct cgg gca ctc aga gag att ccg aaa ttt gcc atc aaa gag      336
 Arg Ala Pro Arg Ala Leu Arg Glu Ile Pro Lys Phe Ala Ile Lys Glu
             100                 105                 110

 gtg gaa act cta agt gtg cgc att gat agc agg ttc aac aaa gct ctc      384
 Val Glu Thr Leu Ser Val Arg Ile Asp Ser Arg Phe Asn Lys Ala Leu
         115                 120                 125

 tgc gcc aaa gga ata agg aat gtc ccg tac cga atc cgt gtg cag ttg      432
 Cys Ala Lys Gly Ile Arg Asn Val Pro Tyr Arg Ile Arg Val Gln Leu
     130                 135                 140

 tcc aga aaa cgt aat gag gat gaa gat tca cca aat aag cta tat act      480
 Ser Arg Lys Arg Asn Glu Asp Glu Asp Ser Pro Asn Lys Leu Tyr Thr
 145                 150                 155                 160

 ttg gtt acc tat gta cct gtt acc act ttc aaa att tct gtg cta aac      528
 Leu Val Thr Tyr Val Pro Val Thr Thr Phe Lys Ile Ser Val Leu Asn
                 165                 170                 175

 agt gtt aca gtc gcc aag agc cca taa aggga gccctcctgg aagtggatga      580
 Ser Val Thr Val Ala Lys Ser Pro 
             180

 ggccttgggt ctcggctctt cattgcttcc tgagctgcag cagatgcctt tacaaccaag    640

 ctcaccgagg acgtctgtct cccatattac cctggcagag ggccaggcct gttctacacg    700

 gccggggttt caacaaggta ctgatgtctt ctgcccttgc ctcttcgaca ggcaagtaat    760

 aagacttaag tgaagagaat tctttaggca cacaaattca catttgatgt aatctcatta    820

 tacttcctga tctgtgattg aaaactttca tttcgtaact agtatgtctg tcccaccttt    880




      <210> 15
      <211> 6014
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(3837)

      <400> 15
 tctcatgcgt ttcccccccc tcgcggcgct cgcccgctct ccctcgctct cgctctgtct     60

 tttttgggcg cc    atg ctg agg gga agg gaa gat gga gag ttg gaa gaa     108
                  Met Leu Arg Gly Arg Glu Asp Gly Glu Leu Glu Glu
                    1               5                  10

 ggc gaa ttg gaa gat gat ggg gca gag gag acc cag gat acc tcc gga      156
 Gly Glu Leu Glu Asp Asp Gly Ala Glu Glu Thr Gln Asp Thr Ser Gly
          15                  20                  25

 ggg cct gag aga agc cgg aaa gaa aag ggg gag aag cat cac agt gat      204
 Gly Pro Glu Arg Ser Arg Lys Glu Lys Gly Glu Lys His His Ser Asp
      30                  35                  40

 tcg gat gag gag aag tcc cac agg aga ctg aag cgg aaa cgg aag aaa      252
 Ser Asp Glu Glu Lys Ser His Arg Arg Leu Lys Arg Lys Arg Lys Lys
  45                  50                  55                  60

 gag cgg gag aaa gag aaa agg agg tcg aag aag agg agg aaa tcc aag      300
 Glu Arg Glu Lys Glu Lys Arg Arg Ser Lys Lys Arg Arg Lys Ser Lys
                  65                  70                  75

 cac aaa cgc cat gct tct tct agc gat gac ttc tct gac ttc tca gat      348
 His Lys Arg His Ala Ser Ser Ser Asp Asp Phe Ser Asp Phe Ser Asp
              80                  85                  90

 gac tcg gat ttc agc ccc agt gag aaa ggt cac cgc aag tac aga gag      396
 Asp Ser Asp Phe Ser Pro Ser Glu Lys Gly His Arg Lys Tyr Arg Glu
          95                 100                 105

 tac agc ccc cca tat gcg ccg tcc cac cag cag tac ccc cca tcg cat      444
 Tyr Ser Pro Pro Tyr Ala Pro Ser His Gln Gln Tyr Pro Pro Ser His
     110                 115                 120

 gcc acg ccc ctg ccc aag aag gca tac tcc aag atg gac agc aag agt      492
 Ala Thr Pro Leu Pro Lys Lys Ala Tyr Ser Lys Met Asp Ser Lys Ser
 125                 130                 135                 140

 tat ggc atg tac gag gac tac gag aat gag cag tat ggg gaa tat gag      540
 Tyr Gly Met Tyr Glu Asp Tyr Glu Asn Glu Gln Tyr Gly Glu Tyr Glu
                 145                 150                 155

 ggc gac gag gag gag gac atg ggc aag gag gac tat gac gac ttc acc      588
 Gly Asp Glu Glu Glu Asp Met Gly Lys Glu Asp Tyr Asp Asp Phe Thr
             160                 165                 170

 aaa gag ctg aac cag tac cgg cgt gcc aag gag ggc agc agc cgc ggc      636
 Lys Glu Leu Asn Gln Tyr Arg Arg Ala Lys Glu Gly Ser Ser Arg Gly
         175                 180                 185

 cga ggc agc cga ggc cgg ggc cgg ggc tac agg ggc cga gga agc cgt      684
 Arg Gly Ser Arg Gly Arg Gly Arg Gly Tyr Arg Gly Arg Gly Ser Arg
     190                 195                 200

 gga gga tcg cga ggc cgc ggc atg ggc agg ggc agc cga ggc agg ggc      732
 Gly Gly Ser Arg Gly Arg Gly Met Gly Arg Gly Ser Arg Gly Arg Gly
 205                 210                 215                 220

 aga ggc tct atg gga gga gac cac ccg gag gat gaa gag gat ttc tac      780
 Arg Gly Ser Met Gly Gly Asp His Pro Glu Asp Glu Glu Asp Phe Tyr
                 225                 230                 235

 gag gaa gag atg gac tat gga gag agt gag gag cca atg gga gac gac      828
 Glu Glu Glu Met Asp Tyr Gly Glu Ser Glu Glu Pro Met Gly Asp Asp
             240                 245                 250

 gac tat gac gag tac tcc aag gag ctg aac cag tac cgc cgc tcc aag      876
 Asp Tyr Asp Glu Tyr Ser Lys Glu Leu Asn Gln Tyr Arg Arg Ser Lys
         255                 260                 265

 gac agc cga ggc cga ggg cta agt cga ggc cgt ggc agg ggc tcc cga      924
 Asp Ser Arg Gly Arg Gly Leu Ser Arg Gly Arg Gly Arg Gly Ser Arg
     270                 275                 280

 ggt cga ggg aaa gga atg ggt cgg ggc cga ggc cga ggt ggc agc cga      972
 Gly Arg Gly Lys Gly Met Gly Arg Gly Arg Gly Arg Gly Gly Ser Arg
 285                 290                 295                 300

 gga ggg atg aac aag ggc gga atg aac gat gac gaa gac ttc tat gac     1020
 Gly Gly Met Asn Lys Gly Gly Met Asn Asp Asp Glu Asp Phe Tyr Asp
                 305                 310                 315

 gag gac atg ggc gac ggt ggt ggt gga agc tac cgg agt cgt gac cat     1068
 Glu Asp Met Gly Asp Gly Gly Gly Gly Ser Tyr Arg Ser Arg Asp His
             320                 325                 330

 gac aag ccc cac cag cag tcg gac aag aaa ggc aaa gtc att tgc aag     1116
 Asp Lys Pro His Gln Gln Ser Asp Lys Lys Gly Lys Val Ile Cys Lys
         335                 340                 345

 tac ttc gtg gaa ggg cgc tgc acc tgg gga gac cac tgt aat ttt agc     1164
 Tyr Phe Val Glu Gly Arg Cys Thr Trp Gly Asp His Cys Asn Phe Ser
     350                 355                 360

 cat gac atc gaa ctg cca aag aag cga gaa ctg tgc aag ttt tac atc     1212
 His Asp Ile Glu Leu Pro Lys Lys Arg Glu Leu Cys Lys Phe Tyr Ile
 365                 370                 375                 380

 act gga ttt tgc gcc aga gct gag aac tgc cct tat atg cac ggt gat     1260
 Thr Gly Phe Cys Ala Arg Ala Glu Asn Cys Pro Tyr Met His Gly Asp
                 385                 390                 395

 ttc ccg tgt aag ctg tac cac acc act ggg aac tgc atc aat ggt gac     1308
 Phe Pro Cys Lys Leu Tyr His Thr Thr Gly Asn Cys Ile Asn Gly Asp
             400                 405                 410

 gac tgc atg ttt tcc cac gac cct ctg acc gaa gag acg agg gag ctc     1356
 Asp Cys Met Phe Ser His Asp Pro Leu Thr Glu Glu Thr Arg Glu Leu
         415                 420                 425

 ttg gat aag atg ttg gcc gat gat gca gaa gca ggt gcc gag gat gag     1404
 Leu Asp Lys Met Leu Ala Asp Asp Ala Glu Ala Gly Ala Glu Asp Glu
     430                 435                 440

 aag gag gtg gag gaa ctg aag aag cag ggc atc aac ccc ctg ccc aaa     1452
 Lys Glu Val Glu Glu Leu Lys Lys Gln Gly Ile Asn Pro Leu Pro Lys
 445                 450                 455                 460

 ccg ccc cct ggt gtg ggc ctc ctg ccc acc cct cct cgg ccc cct ggc     1500
 Pro Pro Pro Gly Val Gly Leu Leu Pro Thr Pro Pro Arg Pro Pro Gly
                 465                 470                 475

 ccg cag gct cca acc tct ccc aac ggc agg ccc atg cag ggt ggc ccc     1548
 Pro Gln Ala Pro Thr Ser Pro Asn Gly Arg Pro Met Gln Gly Gly Pro
             480                 485                 490

 ccg ccc ccg ccc cct ccc cct ccc cca ccg ccc ggg ccc cct cag atg     1596
 Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro Gly Pro Pro Gln Met
         495                 500                 505

 ccc atg ccg gtg cat gag cca ctg tcc ccg cag cag ctg cag cag cag     1644
 Pro Met Pro Val His Glu Pro Leu Ser Pro Gln Gln Leu Gln Gln Gln
     510                 515                 520

 gac atg tac aac aag aag atc ccc tcc ttg ttt gag atc gtg gtg cgg     1692
 Asp Met Tyr Asn Lys Lys Ile Pro Ser Leu Phe Glu Ile Val Val Arg
 525                 530                 535                 540

 ccc acg gga cag ctg gct gag aag ctg ggt gtg agg ttc cct gga cct     1740
 Pro Thr Gly Gln Leu Ala Glu Lys Leu Gly Val Arg Phe Pro Gly Pro
                 545                 550                 555

 ggt gga ccc cca ggg cca atg ggc cct ggg ccc aac atg gga ccc cca     1788
 Gly Gly Pro Pro Gly Pro Met Gly Pro Gly Pro Asn Met Gly Pro Pro
             560                 565                 570

 ggg cca atg ggc ggt cca atg cat cct gac atg cac ccc gac atg cac     1836
 Gly Pro Met Gly Gly Pro Met His Pro Asp Met His Pro Asp Met His
         575                 580                 585

 ccg gac atg cac cct gac atg cac gca gac atg cac gca gac atg ccg     1884
 Pro Asp Met His Pro Asp Met His Ala Asp Met His Ala Asp Met Pro
     590                 595                 600

 atg ggc cct ggc atg aat cct ggc cca ccc atg ggc cct ggc ggc cct     1932
 Met Gly Pro Gly Met Asn Pro Gly Pro Pro Met Gly Pro Gly Gly Pro
 605                 610                 615                 620

 cca atg atg ccc tac ggc cct gga gac tcc cca cat tct gga atg atg     1980
 Pro Met Met Pro Tyr Gly Pro Gly Asp Ser Pro His Ser Gly Met Met
                 625                 630                 635

 ccc cct atc ccg cca gcc cag aac ttc tat gaa aac ttc tac cag cag     2028
 Pro Pro Ile Pro Pro Ala Gln Asn Phe Tyr Glu Asn Phe Tyr Gln Gln
             640                 645                 650

 cag gag ggc atg gag atg gag ccc gga ctc ctg ggg gat gca gag gac     2076
 Gln Glu Gly Met Glu Met Glu Pro Gly Leu Leu Gly Asp Ala Glu Asp
         655                 660                 665

 tac ggg cac tac gaa gag ctg cca ggg gag cct ggg gag cac ctc ttc     2124
 Tyr Gly His Tyr Glu Glu Leu Pro Gly Glu Pro Gly Glu His Leu Phe
     670                 675                 680

 cct gag cac cct ctg gag ccc gac agc ttc tct gag gga ggg ccc cca     2172
 Pro Glu His Pro Leu Glu Pro Asp Ser Phe Ser Glu Gly Gly Pro Pro
 685                 690                 695                 700

 ggc cgg ccg aag cca ggc gcc ggt gtc cct gac ttc ctg ccc tca gcc     2220
 Gly Arg Pro Lys Pro Gly Ala Gly Val Pro Asp Phe Leu Pro Ser Ala
                 705                 710                 715

 cag agg gcc ctg tac ctg agg atc cag cag aag cag cag gag gag gag     2268
 Gln Arg Ala Leu Tyr Leu Arg Ile Gln Gln Lys Gln Gln Glu Glu Glu
             720                 725                 730

 gag aga gcg agg agg ctg gct gag agc agc aag cag gac cgg gag aat     2316
 Glu Arg Ala Arg Arg Leu Ala Glu Ser Ser Lys Gln Asp Arg Glu Asn
         735                 740                 745

 gag gaa ggt gac acc gga aac tgg tac tca agt gat gag gat gag ggt     2364
 Glu Glu Gly Asp Thr Gly Asn Trp Tyr Ser Ser Asp Glu Asp Glu Gly
     750                 755                 760

 gga agc agt gtc acc tcc atc ctg aag acc ttg agg cag cag acg tcc     2412
 Gly Ser Ser Val Thr Ser Ile Leu Lys Thr Leu Arg Gln Gln Thr Ser
 765                 770                 775                 780

 agc cga ccc ccg gct tca gtt ggg gag ctg agc agc agt ggg ctg ggg     2460
 Ser Arg Pro Pro Ala Ser Val Gly Glu Leu Ser Ser Ser Gly Leu Gly
                 785                 790                 795

 gac ccc cgc ctc cag aag gga cac ccc aca gga agc cgg ctg gct gac     2508
 Asp Pro Arg Leu Gln Lys Gly His Pro Thr Gly Ser Arg Leu Ala Asp
             800                 805                 810

 cct cgc ctc agc cgg gac ccc aga ctc acc cgc cat gtg gag gct tct     2556
 Pro Arg Leu Ser Arg Asp Pro Arg Leu Thr Arg His Val Glu Ala Ser
         815                 820                 825

 ggc ggg tct ggc cca ggt gat tcg gga ccc tcc gat cct cgg ctg gct     2604
 Gly Gly Ser Gly Pro Gly Asp Ser Gly Pro Ser Asp Pro Arg Leu Ala
     830                 835                 840

 cgc gcc ctg ccc acc tcc aag ccc gaa ggc agc ctt cat tcc agc cct     2652
 Arg Ala Leu Pro Thr Ser Lys Pro Glu Gly Ser Leu His Ser Ser Pro
 845                 850                 855                 860

 gtg ggc ccc agc agt tcc aag ggg tct ggg ccg ccc cca acg gag gag     2700
 Val Gly Pro Ser Ser Ser Lys Gly Ser Gly Pro Pro Pro Thr Glu Glu
                 865                 870                 875

 gag gaa ggg gag cgg gcc ctg cgg gag aag gcc gtg aac att ccc ctg     2748
 Glu Glu Gly Glu Arg Ala Leu Arg Glu Lys Ala Val Asn Ile Pro Leu
             880                 885                 890

 gac cca ctc ccc ggg cac cct ctg cgg gac cca cgg tca cag ctg cag     2796
 Asp Pro Leu Pro Gly His Pro Leu Arg Asp Pro Arg Ser Gln Leu Gln
         895                 900                 905

 cag ttc agc cac atc aag aag gac gtg acc ctg agc aag ccc agc ttc     2844
 Gln Phe Ser His Ile Lys Lys Asp Val Thr Leu Ser Lys Pro Ser Phe
     910                 915                 920

 gcc cgc acc gtg ctc tgg aat ccc gag gac ctg atc ccc cta ccc atc     2892
 Ala Arg Thr Val Leu Trp Asn Pro Glu Asp Leu Ile Pro Leu Pro Ile
 925                 930                 935                 940

 ccc aag cag gac gca gtg ccc ccc gtg ccc gcg gcc ctg caa tcc atg     2940
 Pro Lys Gln Asp Ala Val Pro Pro Val Pro Ala Ala Leu Gln Ser Met
                 945                 950                 955

 ccc acc ctg gac ccc cgg ctg cac cgc gct gcc acg gca ggg ccc ccc     2988
 Pro Thr Leu Asp Pro Arg Leu His Arg Ala Ala Thr Ala Gly Pro Pro
             960                 965                 970

 aac gcc cgg cag cgc ccg ggc gcc tcc acg gat tcc agc aca cag ggc     3036
 Asn Ala Arg Gln Arg Pro Gly Ala Ser Thr Asp Ser Ser Thr Gln Gly
         975                 980                 985

 gcc aac ctc ccc gac ttt gaa ctt ctg tct cgc atc ctc aag aca gtc     3084
 Ala Asn Leu Pro Asp Phe Glu Leu Leu Ser Arg Ile Leu Lys Thr Val
     990                 995                1000

 aat gcc acc ggc tcc tcg gcc gcc ccc ggt tcc agc gac aaa ccc agt     3132
 Asn Ala Thr Gly Ser Ser Ala Ala Pro Gly Ser Ser Asp Lys Pro Ser
1005                1010                1015                1020

 gac ccc cgg gtg cgg aag gcc ccc acc gac cct cgg ctg cag aaa ccc     3180
 Asp Pro Arg Val Arg Lys Ala Pro Thr Asp Pro Arg Leu Gln Lys Pro
                1025                1030                1035

 aca gac tct acg gcc tcc tcc cgg gct gcc aag ccc ggc cct gct gag     3228
 Thr Asp Ser Thr Ala Ser Ser Arg Ala Ala Lys Pro Gly Pro Ala Glu
            1040                1045                1050

 gcg ccc tct ccc acc gcc agc ccg agt ggg gat gcc tcc cca cca gcc     3276
 Ala Pro Ser Pro Thr Ala Ser Pro Ser Gly Asp Ala Ser Pro Pro Ala
        1055                1060                1065

 acc gct ccc tac gac ccc cgc gtg ctg gcg gcc ggt gga ctg ggc cag     3324
 Thr Ala Pro Tyr Asp Pro Arg Val Leu Ala Ala Gly Gly Leu Gly Gln
    1070                1075                1080

 ggc gga ggg ggc ggg cag agc agt gtg ctg agc ggt atc agc ctc tac     3372
 Gly Gly Gly Gly Gly Gln Ser Ser Val Leu Ser Gly Ile Ser Leu Tyr
1085                1090                1095                1100

 gac ccg agg act ccc aac gcg ggg ggc aaa gcc aca gag ccg gct gct     3420
 Asp Pro Arg Thr Pro Asn Ala Gly Gly Lys Ala Thr Glu Pro Ala Ala
                1105                1110                1115

 gac acg ggt gcc cag ccc aag ggt gct gag ggc aat ggc aag agc tcg     3468
 Asp Thr Gly Ala Gln Pro Lys Gly Ala Glu Gly Asn Gly Lys Ser Ser
            1120                1125                1130

 gcc tcc aag gct aag gag ccc ccg ttc gtc cgc aag tct gcc ctg gaa     3516
 Ala Ser Lys Ala Lys Glu Pro Pro Phe Val Arg Lys Ser Ala Leu Glu
        1135                1140                1145

 cag cca gag aca ggg aag gcc ggt gct gat ggg ggc acc ccc acg gac     3564
 Gln Pro Glu Thr Gly Lys Ala Gly Ala Asp Gly Gly Thr Pro Thr Asp
    1150                1155                1160

 aga tac aac agc tac aac cgg ccc cgg ccc aag gct gct gca gcc ccc     3612
 Arg Tyr Asn Ser Tyr Asn Arg Pro Arg Pro Lys Ala Ala Ala Ala Pro
1165                1170                1175                1180

 gct gcc acc acc gcc acc cca ccc ccc gag ggt gcc cca ccc cag ccc     3660
 Ala Ala Thr Thr Ala Thr Pro Pro Pro Glu Gly Ala Pro Pro Gln Pro
                1185                1190                1195

 ggg gtg cac aac ctg ccc gtg ccc acc ctc ttc ggg acg gtg aag cag     3708
 Gly Val His Asn Leu Pro Val Pro Thr Leu Phe Gly Thr Val Lys Gln
            1200                1205                1210

 aca ccc aag acg ggc tca gga agc cca ttt gct ggg aac agt ccg gcc     3756
 Thr Pro Lys Thr Gly Ser Gly Ser Pro Phe Ala Gly Asn Ser Pro Ala
        1215                1220                1225

 cgc gag ggt gag cag gat gcg gca tcc ctg aag gat gtt ttt aaa ggc     3804
 Arg Glu Gly Glu Gln Asp Ala Ala Ser Leu Lys Asp Val Phe Lys Gly
    1230                1235                1240

 ttc gac ccc acg gcc tcc ccc ttt tgc cag tag tgtccagc cagagctgcg     3855
 Phe Asp Pro Thr Ala Ser Pro Phe Cys Gln 
1245                1250

 gctccagcca cccttcctag ggtggcattc agggcagcac ccagggtagg gaacttgggg   3915

 gcaaggggag gcaggctggg tgttcctttt ttcttttctt tttcttttgc tttccgtctc   3975

 ttttattttt ttttaaagta gtactttctt tgagatttgt aaattgtata taaccatctt   4035

 aagttctggt cagtgtggcg ggctcagggg ctcctgctga gcaaaccgac tcatgcccgc   4095

 aaacctgtga actttcgcca gtgcctggcc tcagactctg tgggctctgc gtggccgggc   4155

 cttgctggag gcccagtggg ttttctgggc aaagcatggc cccttttccc caggacaaag   4215

 ggaacagttg gtgtctggga aggtattgaa cgctcctcac cctgtgcccg aagagacccg   4275

 gaaccaagac catggcaggg cctgcgtgga agcaggtcca ggcgtttcta gaaccctagg   4335

 gtgcaccatc actgtctttt cagtgcaggc tgtaacaacc cactcaggag acagtgagag   4395

 tgaaaaggta ttaaggaaaa agcccccagc ggcactatgg gggctccctg gtgcatgcct   4455

 gctcctgtcc ctggattacc acacgtgccc tccctgccac cctccgtcta gagcaagcgg   4515

 atgcccccca gcctgcagca gaagcctcca cagtgagaac tggacccaaa ggtagtgggg   4575

 gccggtgtgg ggcagagtcc tgaagagcca cctctaggag gcagccccta ggagcacgca   4635

 cgttctgtca gtattacccc acctgtccta tcaggtgggc cacaccctgc ttgcccacac   4695

 cagggtctgt cctggtcctc aagccacgca cccgctatgc ctgcactgca gcccagcccc   4755

 ggacagctcc aggatccgtg cagtggctgc gccgccaggc cccaacaatg gggaccctgg   4815

 ggtggctcct ggccaagtgt tctctgtttt cctcgcacct ccttacactg tgtgacctgc   4875

 agggcatgag gtattgatgt gttcgggttt cctttcccaa gccagcagat gcaggtgttc   4935

 caaggtgtgt tgctctgtgg gatttgtgga cacttaagaa acggactgag tgggaaccct   4995

 gcagccaggg gatggggagc ctctgctccc cccatgctcc caccctggct gagggccagc   5055

 ctcatctgca gagccctgga ggaggcccac ctatggacac agcccgagag atgggcgcaa   5115

 ggggtgctgg gggaggcctg ctatcctgcc tctgggccac ttgaggggcc tcaggaagtg   5175

 tgtgcttgtg gctgcatctg cccgtctccc tggcccacca tgtggctgca ggccaagctc   5235

 ttcattgctg accatgaaga gacctagtta cctgccaagg gattcccctt ccctcctcct   5295

 cagggtgggg tgaacaaggc tcctatccca ccccacccca aaaagagaaa aatgaaaaac   5355

 tcatagtttg gagccaggag gcagggtgtc ctacagggct gcacagccct gaggggtcag   5415

 tgctgggatc tggttggttg gtttgtcttt ttgtcttttt tttttttttt ttttttttac   5475

 acaatcatta atgagatttg tcttcagcca ccagtgttgg ccttgaagca gagggcacag   5535

 cccttggtgt ttgtaaaata agtatgaata cacagtgtgg cagtgttgtg gtttttgttg   5595

 ttgtttttcc tctccttttg agaattttct tttgtaaaag aaaaatattt tttaaaccga   5655

 aatctgtgga tgaaatagaa gctggagccc tcctcttgga atattcagcc taagaacctc   5715

 ataggactat gaattcaccc gaaattctca tttgccatca ggccgagctt ttaaagaaaa   5775

 attgttctct aaccaggatt gtaacaaaag tgtaaatact gtttcagagt tgagagttgg   5835

 tggtgcaaat atgtatataa tgaactgtat ttttacaatg atcgccgcat gactatttca   5895

 cacccttttt atactccata tctgtcttcc agaaacgtca cctgcctttc tcctgtggtc   5955

 tcttaatcca gtaattgtat tactgccatt aaaggatgca gttattttaa aaaaaaaaa    6014




      <210> 16
      <211> 1549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(1495)

      <400> 16
 tttcgtcctg acagtctctg ag atg aca ata ggg aga atg gag aac gtg gag      52
                          Met Thr Ile Gly Arg Met Glu Asn Val Glu
                            1               5                  10

 gtc ttc acc gct gag ggc aaa gga agg ggt ctg aag gcc acc aag gag      100
 Val Phe Thr Ala Glu Gly Lys Gly Arg Gly Leu Lys Ala Thr Lys Glu
                  15                  20                  25

 ttc tgg gct gca gat atc atc ttt gct gag cgg gct tat tcc gca gtg      148
 Phe Trp Ala Ala Asp Ile Ile Phe Ala Glu Arg Ala Tyr Ser Ala Val
              30                  35                  40

 gtt ttt gac agc ctt gtt aat ttt gtg tgc cac acc tgc ttc aag agg      196
 Val Phe Asp Ser Leu Val Asn Phe Val Cys His Thr Cys Phe Lys Arg
          45                  50                  55

 cag gag aag ctc cat cgc tgt ggg cag tgc aag ttt gcc cat tac tgc      244
 Gln Glu Lys Leu His Arg Cys Gly Gln Cys Lys Phe Ala His Tyr Cys
      60                  65                  70

 gac cgc acc tgc cag aag gat gct tgg ctg aac cac aag aat gaa tgt      292
 Asp Arg Thr Cys Gln Lys Asp Ala Trp Leu Asn His Lys Asn Glu Cys
  75                  80                  85                  90

 tcg gcc atc aag aga tat ggg aag gtg ccc aat gag aac atc agg ctg      340
 Ser Ala Ile Lys Arg Tyr Gly Lys Val Pro Asn Glu Asn Ile Arg Leu
                  95                 100                 105

 gcg gcg cgc atc atg tgg agg gtg gag aga gaa ggc acc ggg ctc acg      388
 Ala Ala Arg Ile Met Trp Arg Val Glu Arg Glu Gly Thr Gly Leu Thr
             110                 115                 120

 gag ggc tgc ctg gtg tcc gtg gac gac ttg cag aac cac gtg gag cac      436
 Glu Gly Cys Leu Val Ser Val Asp Asp Leu Gln Asn His Val Glu His
         125                 130                 135

 ttt ggg gag gag gag cag aag gac ctg cgg gtg gac gtg gac aca ttc      484
 Phe Gly Glu Glu Glu Gln Lys Asp Leu Arg Val Asp Val Asp Thr Phe
     140                 145                 150

 ttg cag tac tgg ccg ccg cag agc cag cag ttc agc atg cag tac atc      532
 Leu Gln Tyr Trp Pro Pro Gln Ser Gln Gln Phe Ser Met Gln Tyr Ile
 155                 160                 165                 170

 tcg cac atc ttc gga gtg att aac tgc aac ggt ttt act ctc agt gat      580
 Ser His Ile Phe Gly Val Ile Asn Cys Asn Gly Phe Thr Leu Ser Asp
                 175                 180                 185

 cag aga ggc ctg cag gcc gtg ggc gta ggc atc ttc ccc aac ctg ggc      628
 Gln Arg Gly Leu Gln Ala Val Gly Val Gly Ile Phe Pro Asn Leu Gly
             190                 195                 200

 ctg gtg aac cat gac tgt tgg ccc aac tgt act gtc ata ttt aac aat      676
 Leu Val Asn His Asp Cys Trp Pro Asn Cys Thr Val Ile Phe Asn Asn
         205                 210                 215

 ggc aat cat gag gca gtg aaa tcc atg ttt cat acc cag atg aga att      724
 Gly Asn His Glu Ala Val Lys Ser Met Phe His Thr Gln Met Arg Ile
     220                 225                 230

 gag ctc cgg gcc cta ggc aag atc tca gaa gga gag gag ctg act gtg      772
 Glu Leu Arg Ala Leu Gly Lys Ile Ser Glu Gly Glu Glu Leu Thr Val
 235                 240                 245                 250

 tcc tat att gac ttc ctc aac gtt agt gaa gaa cgc aag agg cag ctg      820
 Ser Tyr Ile Asp Phe Leu Asn Val Ser Glu Glu Arg Lys Arg Gln Leu
                 255                 260                 265

 aag aag cag tac tac ttt gac tgc aca tgt gaa cac tgc cag aaa aaa      868
 Lys Lys Gln Tyr Tyr Phe Asp Cys Thr Cys Glu His Cys Gln Lys Lys
             270                 275                 280

 ctg aag gat gac ctc ttc ctg ggg gtg aaa gac aac ccc aag ccc tct      916
 Leu Lys Asp Asp Leu Phe Leu Gly Val Lys Asp Asn Pro Lys Pro Ser
         285                 290                 295

 cag gaa gtg gtg aag gag atg ata caa ttc tcc aag gat aca ttg gaa      964
 Gln Glu Val Val Lys Glu Met Ile Gln Phe Ser Lys Asp Thr Leu Glu
     300                 305                 310

 aag ata gac aag gct cgt tcc gag ggt ttg tat cat gag gtt gtg aaa     1012
 Lys Ile Asp Lys Ala Arg Ser Glu Gly Leu Tyr His Glu Val Val Lys
 315                 320                 325                 330

 tta tgc cgg gag tgc ctg gag aag cag gag cca gtg ttt gct gac acc     1060
 Leu Cys Arg Glu Cys Leu Glu Lys Gln Glu Pro Val Phe Ala Asp Thr
                 335                 340                 345

 aac atc tac atg ctg cgg atg ctg agc att gtt tcg gag gtc ctt tcc     1108
 Asn Ile Tyr Met Leu Arg Met Leu Ser Ile Val Ser Glu Val Leu Ser
             350                 355                 360

 tac ctc cag gcc ttt gag gag gcc tcg ttc tat gcc agg agg atg gtg     1156
 Tyr Leu Gln Ala Phe Glu Glu Ala Ser Phe Tyr Ala Arg Arg Met Val
         365                 370                 375

 gac ggc tat atg aag ctc tac cac ccc aac aat gcc caa ctg ggc atg     1204
 Asp Gly Tyr Met Lys Leu Tyr His Pro Asn Asn Ala Gln Leu Gly Met
     380                 385                 390

 gcc gtg atg cgg gca ggg ctg acc aac tgg cac gct ggt aac att gag     1252
 Ala Val Met Arg Ala Gly Leu Thr Asn Trp His Ala Gly Asn Ile Glu
 395                 400                 405                 410

 gtg ggg cac ggg atg atc tgc aaa gcc tat gcc att ctc ctg gtg aca     1300
 Val Gly His Gly Met Ile Cys Lys Ala Tyr Ala Ile Leu Leu Val Thr
                 415                 420                 425

 cac gga ccc tcc cac ccc atc act aag gac tta gag gcc atg cgg gtg     1348
 His Gly Pro Ser His Pro Ile Thr Lys Asp Leu Glu Ala Met Arg Val
             430                 435                 440

 cag acg gag atg gag cta cgc atg ttc cgc cag aac gaa ttc atg tac     1396
 Gln Thr Glu Met Glu Leu Arg Met Phe Arg Gln Asn Glu Phe Met Tyr
         445                 450                 455

 tac aag atg cgc gag gct gcc ctg aac aac cag ccc atg cag gtc atg     1444
 Tyr Lys Met Arg Glu Ala Ala Leu Asn Asn Gln Pro Met Gln Val Met
     460                 465                 470

 gcc gag ccc agc aat gag cca tcc cca gct ctg ttc cac aag aag caa     1492
 Ala Glu Pro Ser Asn Glu Pro Ser Pro Ala Leu Phe His Lys Lys Gln
 475                 480                 485                 490

 tga ggac tgcccagtgg aggaggggcg atgtggctgg ggagctaggg agagactctg     1549
 






      <210> 17
      <211> 1890
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (289)..(1836)

      <400> 17
 atgactggtc ctgcggataa gggtgtgcgc gagagccaat caaaagcgga tgtcgaaaag     60

 aggcgccgct ccagccagtc acgtcgcgag gtgcggtcgg ggccggctga cgcgactgcg    120

 ggcctcagcc aatgggcgtg ccactgcccg tccgctcttc agcagccggt cgcgggcggt    180

 ggaaaagcga gtgaagagag cgcgacggcg gcggcggcgg cggcgcagca gctattgctg    240

 gacggccagt gggagagcga ggcctgagcc tctgcgtcta ggatcaaa atg gtt tca     297
                                                      Met Val Ser
                                                        1

 atc cca gaa tac tat gaa ggc aag aac gtc ctc ctc aca gga gct acc      345
 Ile Pro Glu Tyr Tyr Glu Gly Lys Asn Val Leu Leu Thr Gly Ala Thr
       5                  10                  15

 ggt ttt cta ggg aag gtg ctt ctg gaa aag ttg ctg agg tct tgt cct      393
 Gly Phe Leu Gly Lys Val Leu Leu Glu Lys Leu Leu Arg Ser Cys Pro
  20                  25                  30                  35

 aag gtg aat tca gta tat gtt ttg gtg agg cag aaa gct gga cag aca      441
 Lys Val Asn Ser Val Tyr Val Leu Val Arg Gln Lys Ala Gly Gln Thr
                  40                  45                  50

 cca caa gag cga gtg gaa gaa gtc ctt agt ggc aag ctt ttt gac aga      489
 Pro Gln Glu Arg Val Glu Glu Val Leu Ser Gly Lys Leu Phe Asp Arg
              55                  60                  65

 ttg aga gat gaa aat cca gat ttt aga gag aaa att ata gca atc aac      537
 Leu Arg Asp Glu Asn Pro Asp Phe Arg Glu Lys Ile Ile Ala Ile Asn
          70                  75                  80

 agc gaa ctc acc caa cct aaa ctg gct ctc agt gaa gaa gat aaa gag      585
 Ser Glu Leu Thr Gln Pro Lys Leu Ala Leu Ser Glu Glu Asp Lys Glu
      85                  90                  95

 gtg atc ata gat tct acc aat att ata ttc cac tgt gca gct aca gta      633
 Val Ile Ile Asp Ser Thr Asn Ile Ile Phe His Cys Ala Ala Thr Val
 100                 105                 110                 115

 agg ttt aat gaa aat tta aga gat gct gtt cag tta aat gtg att gca      681
 Arg Phe Asn Glu Asn Leu Arg Asp Ala Val Gln Leu Asn Val Ile Ala
                 120                 125                 130

 acg cga cag ctt att ctc ctt gca caa caa atg aag aat ctg gaa gtg      729
 Thr Arg Gln Leu Ile Leu Leu Ala Gln Gln Met Lys Asn Leu Glu Val
             135                 140                 145

 ttc atg cat gta tca aca gca tat gcc tac tgt aat cgc aag cat att      777
 Phe Met His Val Ser Thr Ala Tyr Ala Tyr Cys Asn Arg Lys His Ile
         150                 155                 160

 gat gaa gta gtc tat cca cca cct gtg gat ccc aag aag ctg att gat      825
 Asp Glu Val Val Tyr Pro Pro Pro Val Asp Pro Lys Lys Leu Ile Asp
     165                 170                 175

 tct tta gag tgg atg gat gat ggc cta gta aat gat atc acg cca aaa      873
 Ser Leu Glu Trp Met Asp Asp Gly Leu Val Asn Asp Ile Thr Pro Lys
 180                 185                 190                 195

 ttg ata gga gac aga cct aat aca tac ata tac aca aaa gca ttg gca      921
 Leu Ile Gly Asp Arg Pro Asn Thr Tyr Ile Tyr Thr Lys Ala Leu Ala
                 200                 205                 210

 gaa tat gtt gta caa caa gaa gga gca aaa cta aat gtg gca att gta      969
 Glu Tyr Val Val Gln Gln Glu Gly Ala Lys Leu Asn Val Ala Ile Val
             215                 220                 225

 agg cca tcg att gtt ggt gcc agt tgg aaa gaa cct ttt cca gga tgg     1017
 Arg Pro Ser Ile Val Gly Ala Ser Trp Lys Glu Pro Phe Pro Gly Trp
         230                 235                 240

 att gat aac ttt aat gga cca agt ggt ctc ttt att gcg gca ggg aaa     1065
 Ile Asp Asn Phe Asn Gly Pro Ser Gly Leu Phe Ile Ala Ala Gly Lys
     245                 250                 255

 gga att ctt cga aca ata cgt gcc tcc aac aat gcc ctt gca gat ctt     1113
 Gly Ile Leu Arg Thr Ile Arg Ala Ser Asn Asn Ala Leu Ala Asp Leu
 260                 265                 270                 275

 gtt cct gta gat gta gtt gtc aac atg agt ctt gcg gca gcc tgg tat     1161
 Val Pro Val Asp Val Val Val Asn Met Ser Leu Ala Ala Ala Trp Tyr
                 280                 285                 290

 tcc gga gtt aat aga cca aga aac atc atg gtg tat aat tgt aca aca     1209
 Ser Gly Val Asn Arg Pro Arg Asn Ile Met Val Tyr Asn Cys Thr Thr
             295                 300                 305

 ggc agc act aat cct ttc cac tgg ggt gaa gtt gag tac cat gta att     1257
 Gly Ser Thr Asn Pro Phe His Trp Gly Glu Val Glu Tyr His Val Ile
         310                 315                 320

 tcc act ttc aag agg aat cct ctc gaa cag gcc ttc aga cgg ccc aat     1305
 Ser Thr Phe Lys Arg Asn Pro Leu Glu Gln Ala Phe Arg Arg Pro Asn
     325                 330                 335

 gta aat cta acc tcc aat cat ctt tta tat cat tac tgg att gct gta     1353
 Val Asn Leu Thr Ser Asn His Leu Leu Tyr His Tyr Trp Ile Ala Val
 340                 345                 350                 355

 agc cat aag gcc cca gca ttc ctg tat gat atc tac ctc agg atg act     1401
 Ser His Lys Ala Pro Ala Phe Leu Tyr Asp Ile Tyr Leu Arg Met Thr
                 360                 365                 370

 gga aga agc cca agg atg atg aaa aca ata act cgt ctt cac aaa gct     1449
 Gly Arg Ser Pro Arg Met Met Lys Thr Ile Thr Arg Leu His Lys Ala
             375                 380                 385

 atg gtg ttt ctt gaa tat ttc aca agt aat tct tgg gtt tgg aat act     1497
 Met Val Phe Leu Glu Tyr Phe Thr Ser Asn Ser Trp Val Trp Asn Thr
         390                 395                 400

 gag aat gtc aat atg tta atg aat caa cta aac cct gaa gat aaa aag     1545
 Glu Asn Val Asn Met Leu Met Asn Gln Leu Asn Pro Glu Asp Lys Lys
     405                 410                 415

 acc ttc aat att gat gta cgg cag tta cat tgg gca gaa tat ata gag     1593
 Thr Phe Asn Ile Asp Val Arg Gln Leu His Trp Ala Glu Tyr Ile Glu
 420                 425                 430                 435

 aac tac tgc ttg gga act aag aag tac gta ttg aat gaa gaa atg tct     1641
 Asn Tyr Cys Leu Gly Thr Lys Lys Tyr Val Leu Asn Glu Glu Met Ser
                 440                 445                 450

 ggc ctc cct gca gcc aga aaa cat ctg aac aag ttg cgg aat ata cgt     1689
 Gly Leu Pro Ala Ala Arg Lys His Leu Asn Lys Leu Arg Asn Ile Arg
             455                 460                 465

 tat ggt ttt aat act atc ctt gtg atc ctc atc tgg cgc att ttt att     1737
 Tyr Gly Phe Asn Thr Ile Leu Val Ile Leu Ile Trp Arg Ile Phe Ile
         470                 475                 480

 gca aga tca caa atg gca aga aat atc tgg tac ttt gtg gtt agt ctg     1785
 Ala Arg Ser Gln Met Ala Arg Asn Ile Trp Tyr Phe Val Val Ser Leu
     485                 490                 495

 tgt tac aag ttt ttg tca tac ttc cga gca tcc agc act atg aga tac     1833
 Cys Tyr Lys Phe Leu Ser Tyr Phe Arg Ala Ser Ser Thr Met Arg Tyr
 500                 505                 510                 515

 tga agac caaggattca gcattagaac atctatacat atggtgatct aaatgtacaa     1890
 






      <210> 18
      <211> 4808
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (818)..(2359)

      <400> 18
 tttcgtcgcg gctggacgct cgccttggct gggggtgtgg gggggcacgc cgggggccaa     60

 ggaggactgt cgaggaggag tgatgagaag agggggtgcc ctgcaccccc cgagaccacg    120

 ggccacgctg tcacttgcca ggcgcccccc ttcctcccag gcgaggggca ggtgttccac    180

 actgattctc gtgactttaa ggaccaggga tttgaagagg tattagctct tcccaggaag    240

 ggaggaagtt tctggaagag aagggaaaga cggcagacgc tgcgctggga ccagcacagc    300

 ctgaggagct gtgggaagct gacagagccc agccaaagga gcgggaagga gccgcagccc    360

 caggctggca ctgtgttctg aaagatttga actcaagctg ctttttacgg aagaggggcc    420

 acttcagagg gcaccccaga atttggttga gctcttctac tctggatgcc ccctgctctg    480

 aggagcctgc cactgagaac caaagaagat aagaggacag atactttttc ttcaagcaca    540

 gagctggtgg gttggagtca ggcatctgca cccctagtgg ctgtctggtg aggaatttct    600

 tgtttcttcc cagcttgcgg cttcagtgct tgatggggct gcctgttggt ggatcagttt    660

 ttgcagtgcc tggtaagagt ggagagccgt gggaagaggt cctgcggcgc ccaagcctgg    720

 gttcacccca agactaagtt ctttcccaag ttagagaaga agagagaaag caaaaagaag    780

 agaggaaagt tctcccttcc cctcctccgt gcctgtc atg tcc tct aag cca gag     835
                                          Met Ser Ser Lys Pro Glu
                                            1               5

 ccg aag gac gtc cac caa ctg aac ggg act ggc cct tct gcc tct ccc      883
 Pro Lys Asp Val His Gln Leu Asn Gly Thr Gly Pro Ser Ala Ser Pro
              10                  15                  20

 tgc tct tca gat ggc cca ggg aga gag ccc ttg gct ggg acc tca gag      931
 Cys Ser Ser Asp Gly Pro Gly Arg Glu Pro Leu Ala Gly Thr Ser Glu
          25                  30                  35

 ttc ctg ggg cct gat ggg gct ggg gta gag gtg gtg att gag tct cgg      979
 Phe Leu Gly Pro Asp Gly Ala Gly Val Glu Val Val Ile Glu Ser Arg
      40                  45                  50

 gcc aac gcc aag ggg gtt cgg gag gag gac gcc ctg ctg gag aac ggg     1027
 Ala Asn Ala Lys Gly Val Arg Glu Glu Asp Ala Leu Leu Glu Asn Gly
  55                  60                  65                  70

 agc cag agc aac gaa agt gac gac gtc agc aca gac cgt ggc cct gcg     1075
 Ser Gln Ser Asn Glu Ser Asp Asp Val Ser Thr Asp Arg Gly Pro Ala
                  75                  80                  85

 cca cct tcc ccg ctc aag gag acc tcc ttt tcc atc ggg ctg caa gta     1123
 Pro Pro Ser Pro Leu Lys Glu Thr Ser Phe Ser Ile Gly Leu Gln Val
              90                  95                 100

 ctg ttt cca ttc ctc ctg gca ggc ttt ggg acc gtg gct gct ggc atg     1171
 Leu Phe Pro Phe Leu Leu Ala Gly Phe Gly Thr Val Ala Ala Gly Met
         105                 110                 115

 gtg ttg gac atc gtg cag cac tgg gaa gtc ttc cag aag gtg aca gag     1219
 Val Leu Asp Ile Val Gln His Trp Glu Val Phe Gln Lys Val Thr Glu
     120                 125                 130

 gtc ttc atc cta gtg cct gcg ctg ctg ggg ctc aaa ggg aac ctg gaa     1267
 Val Phe Ile Leu Val Pro Ala Leu Leu Gly Leu Lys Gly Asn Leu Glu
 135                 140                 145                 150

 atg acc ctg gca tca agg ctt tcc act gca gcc aac att gga cac atg     1315
 Met Thr Leu Ala Ser Arg Leu Ser Thr Ala Ala Asn Ile Gly His Met
                 155                 160                 165

 gac aca ccc aag gag ctc tgg cgg atg atc act ggg aac atg gcc ctc     1363
 Asp Thr Pro Lys Glu Leu Trp Arg Met Ile Thr Gly Asn Met Ala Leu
             170                 175                 180

 atc cag gtg cag gcc acg gtg gtg ggc ttc ctg gcg tcc atc gca gcc     1411
 Ile Gln Val Gln Ala Thr Val Val Gly Phe Leu Ala Ser Ile Ala Ala
         185                 190                 195

 gtc gtc ttt ggc tgg atc cct gat ggc cac ttc agt att ccg cac gcc     1459
 Val Val Phe Gly Trp Ile Pro Asp Gly His Phe Ser Ile Pro His Ala
     200                 205                 210

 ttc ctg ctc tgt gct agc agc gtg gcc aca gcc ttc att gcc tcc ctg     1507
 Phe Leu Leu Cys Ala Ser Ser Val Ala Thr Ala Phe Ile Ala Ser Leu
 215                 220                 225                 230

 gta ctg ggt atg atc atg att gga gtc atc att ggc tct cgc aag att     1555
 Val Leu Gly Met Ile Met Ile Gly Val Ile Ile Gly Ser Arg Lys Ile
                 235                 240                 245

 ggg atc aac cca gac aac gtg gcc aca ccc att gct gcc agc ctg ggc     1603
 Gly Ile Asn Pro Asp Asn Val Ala Thr Pro Ile Ala Ala Ser Leu Gly
             250                 255                 260

 gac ctc atc acc ttg gcg ctg ctc tca ggc atc agc tgg gga ctc tac     1651
 Asp Leu Ile Thr Leu Ala Leu Leu Ser Gly Ile Ser Trp Gly Leu Tyr
         265                 270                 275

 ctg gaa ctg aat cac tgg cga tac atc tac cca ctg gtg tgt gct ttc     1699
 Leu Glu Leu Asn His Trp Arg Tyr Ile Tyr Pro Leu Val Cys Ala Phe
     280                 285                 290

 ttt gtg gcc ctg ctg cct gtc tgg gtg gtg ctg gcc cga cga agt cca     1747
 Phe Val Ala Leu Leu Pro Val Trp Val Val Leu Ala Arg Arg Ser Pro
 295                 300                 305                 310

 gcc aca agg gag gtg ttg tac tcg ggc tgg gag cct gtt atc att gcc     1795
 Ala Thr Arg Glu Val Leu Tyr Ser Gly Trp Glu Pro Val Ile Ile Ala
                 315                 320                 325

 atg gcc atc agc agt gtg gga ggc ctc atc ttg gac aag act gtc tca     1843
 Met Ala Ile Ser Ser Val Gly Gly Leu Ile Leu Asp Lys Thr Val Ser
             330                 335                 340

 gac ccc aac ttt gct ggg atg gct gtc ttc acg cct gtg att aat ggt     1891
 Asp Pro Asn Phe Ala Gly Met Ala Val Phe Thr Pro Val Ile Asn Gly
         345                 350                 355

 gtt ggg ggc aat ctg gtg gca gtg cag gcc agc cgc atc tcc acc ttc     1939
 Val Gly Gly Asn Leu Val Ala Val Gln Ala Ser Arg Ile Ser Thr Phe
     360                 365                 370

 ctg cac atg aat gga atg ccc gga gag aac tct gag caa gct cct cgc     1987
 Leu His Met Asn Gly Met Pro Gly Glu Asn Ser Glu Gln Ala Pro Arg
 375                 380                 385                 390

 cgc tgt ccc agt cct tgt acc acc ttc ttc agc cct gat gtg aat tct     2035
 Arg Cys Pro Ser Pro Cys Thr Thr Phe Phe Ser Pro Asp Val Asn Ser
                 395                 400                 405

 cgc tca gcc cgg gtc ctc ttc ctc ctc gtg gtc cca gga cac ctg gtg     2083
 Arg Ser Ala Arg Val Leu Phe Leu Leu Val Val Pro Gly His Leu Val
             410                 415                 420

 ttc ctc tac acc atc agc tgt atg cag ggc ggg cac acc acc ctc aca     2131
 Phe Leu Tyr Thr Ile Ser Cys Met Gln Gly Gly His Thr Thr Leu Thr
         425                 430                 435

 ctc atc ttc atc atc ttc tat atg aca gct gca ctg ctc cag gtg ctg     2179
 Leu Ile Phe Ile Ile Phe Tyr Met Thr Ala Ala Leu Leu Gln Val Leu
     440                 445                 450

 att ctc ctg tac atc gca gac tgg atg gtg cac tgg atg tgg ggc cgg     2227
 Ile Leu Leu Tyr Ile Ala Asp Trp Met Val His Trp Met Trp Gly Arg
 455                 460                 465                 470

 ggc ctg gac ccg gac aac ttc tcc atc cca tac ttg act gct ctg ggg     2275
 Gly Leu Asp Pro Asp Asn Phe Ser Ile Pro Tyr Leu Thr Ala Leu Gly
                 475                 480                 485

 gac ctg ctt ggc act ggg ctc cta gca ctc agc ttc cat gtt ctc tgg     2323
 Asp Leu Leu Gly Thr Gly Leu Leu Ala Leu Ser Phe His Val Leu Trp
             490                 495                 500

 ctc ata ggg gac cga gac acg gat gtc ggg gac tag cttg gtcactcaac     2373
 Leu Ile Gly Asp Arg Asp Thr Asp Val Gly Asp 
         505                 510

 attttcccca tccctctgca ctttctattt gaaatttttc ttttgttccc ctgtccctcc   2433

 tccaccccac actcccacct ctttctagga cttcactttg ataccaaatt ctcattattt   2493

 tcaatgggaa tttttataca ttgagccaag tttgtatagc aagaatttgg gaaacacaga   2553

 tggcctgaga taagcagtac aagtaggttt ttgagacaat caccaagtgc agtttcatgg   2613

 tgggtgcctc caggtgatgt ggactggagc aggggagttt tgtctggaat ctggggacat   2673

 ggggtttggc tttagcaacc tgtcttggcc ctaatgagaa accctttgta agtgggctct   2733

 ggatttttgg ttttgttttc tttttatctg ttttgtttta tttttggttt tggttgaaca   2793

 gagggacaga agaataagta acactcccaa acacagacat acttttgtag aagtggacca   2853

 acttcaaagc tctggacagg agacacctgc tccaggcccc tgtgatccca gttctgttct   2913

 cttgccctct ggacctaagc gttcccactc gcagaaagag taaggtggac tgacttttca   2973

 atttgtgcac atgcctcttg ttcaatggcc tggtcaacat caacaacccc tccctctgat   3033

 catttccagt tgattgtcat atccaggaaa aaatggaaca gtgcactctt ctccctgttg   3093

 acccatgtcc acctattggt tccccaaaat ccacattctc cctgggccca gatgactttg   3153

 tctccctggg cccagattct ttgtctctct tcaaccttca tctcaaattg tctctaagca   3213

 ctaccttccc cagagcttgc caggttgggt tttgagatta gggtcaggtc atgggtatgt   3273

 ggagaatggt ttggaggttg aggacaacca caggtgtctc attgctgcca tttctcctga   3333

 ggacataatc acttggtcac cttggaccct gtcacttcct aaaattactc gttctgtcat   3393

 gccatagagg tcagttttcc tctttcttgg cttctaccca caaacattca ccaatcattt   3453

 attcgttcat ttagcaaata tgcagcctcc gcaagatgag ctctcctgca gacaagcatg   3513

 gtctgaaaca ttctttgagc aatatcatat tgagtgccta ctatgtgtta ggtactgtgc   3573

 caggaactga taagccagtg gtaagggaaa cacagctcta acctcacctc attctccagg   3633

 ttacaaaggc catgtgcccc tttgaatctg gcagagaaag tttcctcgtt gtaagtattt   3693

 gcatctactt caagccagat tcttctgcct ctttctcctt tccagacccc tactctgtgc   3753

 agtgctgacc acagctagag ccaccgcccc attgctcaac cagtatttat ttccctaaac   3813

 gacccttcct cacattccct tccctccacc tctccttacc aagcacccaa aagaggattt   3873

 agaactagca gggtggacat catctggttg tttctacttt tctctgccta gcacaaaatt   3933

 gggagaaaac tggagcctcc atccgcagtc acacgtgtac agatctgggg atttggatgt   3993

 aggctttttc taacttctct ctcagaagct tctacagaaa cccttccatc tgtagcctca   4053

 agggcccacc tccaagggaa ggcttaggca atgatcctgt ttctaccaac actgcacctt   4113

 atcccaggaa cctgccctag acctccagag accatatttt ctctccctcc atttctaccc   4173

 agacctccag gcctccttct ggaatcatag aaccgtagaa ttggaaggaa ttttagaggt   4233

 tttctagttg gagttgtgtc caacagaatt cattaacacc agcctgggct tgtttttcct   4293

 cctccctctg gacttttttc atcttttcct ccacctcaaa aaatacttac acacagattc   4353

 ttcttgtaca ggcatcaaaa ccaactcctc tgcccctaag gctgtgtccc tgtggtctcc   4413

 agccacccct accccagtca ctcgcccctt cctcatctct ggaatttggc caggcagtcc   4473

 cagaagactc tggagtgacc tcctttgcct aaaaagcaga cagataggca tgccccaggc   4533

 cctgagtgag cagaggagga ctgtagggtg agagggaaag aaaatgaagg tgactttcat   4593

 ggaagtttca tttcttttcc ccgattgtac caactgcatg tacttttggc ctggctgcaa   4653

 ggagcaatat tggtttactc tcgtatcctt aaaaagttac agaactgtgt cttaagagaa   4713

 ttatttatag ttactataac tgaattgaca aatgtcaact taactgataa attatatttg   4773

 gtaaaataaa gaggacgttt atttaaaaaa aaaaa                              4808




      <210> 19
      <211> 4692
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(4642)

      <400> 19
 caggcaaggc ttatctggtg aaaacttttt tgctatgctc agagggtacc gagtagaaaa     60

 ttatgaccca aaagggacca ttgctttgtg gtcataattt tctactcggt accctctgag    120

 catagcaaat tatgaccaca aagca  atg gtc cct ttt ggg ttc cct gaa ttt     172
                              Met Val Pro Phe Gly Phe Pro Glu Phe
                                1               5

 ttc cgc tgt gac cct gca atc tct ccg agc ctt cat gca gca gca cag      220
 Phe Arg Cys Asp Pro Ala Ile Ser Pro Ser Leu His Ala Ala Ala Gln
  10                  15                  20                  25

 att tct agg gga gaa ttt gtc cgc atc tca gga tta gat tat gtg gac      268
 Ile Ser Arg Gly Glu Phe Val Arg Ile Ser Gly Leu Asp Tyr Val Asp
                  30                  35                  40

 agt gcc ctc ctg atg ggg aga gac agg gac aag cct ttc aaa cgg agg      316
 Ser Ala Leu Leu Met Gly Arg Asp Arg Asp Lys Pro Phe Lys Arg Arg
              45                  50                  55

 ttg aaa tca gag tcg gtg gaa aca tct ctc ttc cga aag ctt cga act      364
 Leu Lys Ser Glu Ser Val Glu Thr Ser Leu Phe Arg Lys Leu Arg Thr
          60                  65                  70

 gtt aaa agt gag cac gaa act ttc aag ttc acg tct gag ctg gag gag      412
 Val Lys Ser Glu His Glu Thr Phe Lys Phe Thr Ser Glu Leu Glu Glu
      75                  80                  85

 agc cga ctg gag agg ggc att cgc cct tgg aat tgt cag cga tgt ttt      460
 Ser Arg Leu Glu Arg Gly Ile Arg Pro Trp Asn Cys Gln Arg Cys Phe
  90                  95                 100                 105

 gca cat tat gat gtc cag agc att ttg ttt aat atc aac gaa gcc atg      508
 Ala His Tyr Asp Val Gln Ser Ile Leu Phe Asn Ile Asn Glu Ala Met
                 110                 115                 120

 gct acg agg gct aat gtg ggg aaa agg aaa aac ata acc act ggg gca      556
 Ala Thr Arg Ala Asn Val Gly Lys Arg Lys Asn Ile Thr Thr Gly Ala
             125                 130                 135

 tct gca gca tcc cag act cag atg cct acg ggc cag aca ggc aac tgt      604
 Ser Ala Ala Ser Gln Thr Gln Met Pro Thr Gly Gln Thr Gly Asn Cys
         140                 145                 150

 gag tcc cct tta ggg agc aag gag gac ctc aac tcc aaa gag aac ctg      652
 Glu Ser Pro Leu Gly Ser Lys Glu Asp Leu Asn Ser Lys Glu Asn Leu
     155                 160                 165

 gat gcc gat gag ggt gat ggg aaa agt aac gac ctc gtc ctt agt tgt      700
 Asp Ala Asp Glu Gly Asp Gly Lys Ser Asn Asp Leu Val Leu Ser Cys
 170                 175                 180                 185

 cct tac ttt aga aat gag act gga ggg gaa ggc gac agg cgg att gcg      748
 Pro Tyr Phe Arg Asn Glu Thr Gly Gly Glu Gly Asp Arg Arg Ile Ala
                 190                 195                 200

 ctc tct cga gcc aac tca tcc tct ttc agt tct ggg gaa agc tgc tct      796
 Leu Ser Arg Ala Asn Ser Ser Ser Phe Ser Ser Gly Glu Ser Cys Ser
             205                 210                 215

 ttc gaa tcg tca ctc agc tct cac tgc aca aat gca ggt gtc tcc gtc      844
 Phe Glu Ser Ser Leu Ser Ser His Cys Thr Asn Ala Gly Val Ser Val
         220                 225                 230

 ttg gaa gtg ccc aga gaa aac cag cct att cac agg gag aaa gtg aag      892
 Leu Glu Val Pro Arg Glu Asn Gln Pro Ile His Arg Glu Lys Val Lys
     235                 240                 245

 cgc tac atc ata gaa cac att gac ctt ggg gcc tat tat tac cgc aaa      940
 Arg Tyr Ile Ile Glu His Ile Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys
 250                 255                 260                 265

 ttc ttc tat ggg aaa gag cac caa aac tac ttt gga ata gat gaa aac      988
 Phe Phe Tyr Gly Lys Glu His Gln Asn Tyr Phe Gly Ile Asp Glu Asn
                 270                 275                 280

 ctt ggt cca gta gca gtc agc atc cgg aga gag aag gtg gaa gat gcc     1036
 Leu Gly Pro Val Ala Val Ser Ile Arg Arg Glu Lys Val Glu Asp Ala
             285                 290                 295

 aag gag aaa gaa gga tcc cag ttc aac tac agg gtg gct ttc agg aca     1084
 Lys Glu Lys Glu Gly Ser Gln Phe Asn Tyr Arg Val Ala Phe Arg Thr
         300                 305                 310

 agt gag ctt aca aca ctg aga gga gca att tta gaa gat gct ata ccc     1132
 Ser Glu Leu Thr Thr Leu Arg Gly Ala Ile Leu Glu Asp Ala Ile Pro
     315                 320                 325

 tct act gct agg cat ggt acc gca cga gga cta cct ctc aaa gaa gtt     1180
 Ser Thr Ala Arg His Gly Thr Ala Arg Gly Leu Pro Leu Lys Glu Val
 330                 335                 340                 345

 ttg gaa tac gtc att cca gag ctg agc att cag tgt ttg cga cag gct     1228
 Leu Glu Tyr Val Ile Pro Glu Leu Ser Ile Gln Cys Leu Arg Gln Ala
                 350                 355                 360

 tcc aac tca ccc aag gtc tca gag cag ctg ctc aag ctt gat gaa caa     1276
 Ser Asn Ser Pro Lys Val Ser Glu Gln Leu Leu Lys Leu Asp Glu Gln
             365                 370                 375

 ggg ctg agc ttt cag cac aag atc ggg atc ctt tat tgc aaa gca ggc     1324
 Gly Leu Ser Phe Gln His Lys Ile Gly Ile Leu Tyr Cys Lys Ala Gly
         380                 385                 390

 cag agc aca gag gaa gag atg tat aac aat gag acg gcg gga cca gct     1372
 Gln Ser Thr Glu Glu Glu Met Tyr Asn Asn Glu Thr Ala Gly Pro Ala
     395                 400                 405

 ttt gaa gaa ttc ctt gat ctt ctg ggc cag aga gtc cga ctg aaa gga     1420
 Phe Glu Glu Phe Leu Asp Leu Leu Gly Gln Arg Val Arg Leu Lys Gly
 410                 415                 420                 425

 ttt agt aaa tat cga gct cag cta gac aat aag act gat tcc acg ggc     1468
 Phe Ser Lys Tyr Arg Ala Gln Leu Asp Asn Lys Thr Asp Ser Thr Gly
                 430                 435                 440

 acg cac tct ctc tat acc aca tac aaa gac tac gaa ctc atg ttc cac     1516
 Thr His Ser Leu Tyr Thr Thr Tyr Lys Asp Tyr Glu Leu Met Phe His
             445                 450                 455

 gtg tca acc ctg ctt ccc tac atg ccc aac aac aga caa cag cta ctg     1564
 Val Ser Thr Leu Leu Pro Tyr Met Pro Asn Asn Arg Gln Gln Leu Leu
         460                 465                 470

 agg aaa agg cac ata gga aat gac atc gtc acc atc gtc ttc cag gag     1612
 Arg Lys Arg His Ile Gly Asn Asp Ile Val Thr Ile Val Phe Gln Glu
     475                 480                 485

 cct ggg gca ctt cct ttt act cca aaa agc atc cgg tct cac ttt cag     1660
 Pro Gly Ala Leu Pro Phe Thr Pro Lys Ser Ile Arg Ser His Phe Gln
 490                 495                 500                 505

 cat gtc ttt gtc ata gtc aaa gtg cat aat cca tgt acc gaa aat gtg     1708
 His Val Phe Val Ile Val Lys Val His Asn Pro Cys Thr Glu Asn Val
                 510                 515                 520

 tgt tat agt gtt gga gtt tcc aga tca aaa gat gtg cca cca ttt ggc     1756
 Cys Tyr Ser Val Gly Val Ser Arg Ser Lys Asp Val Pro Pro Phe Gly
             525                 530                 535

 cca ccg att ccc aaa ggt gta act ttt cca aag tca gcc gtg ttc cgg     1804
 Pro Pro Ile Pro Lys Gly Val Thr Phe Pro Lys Ser Ala Val Phe Arg
         540                 545                 550

 gac ttc ctt tta gcc aaa gta atc aat gca gaa aat gca gcc cat aaa     1852
 Asp Phe Leu Leu Ala Lys Val Ile Asn Ala Glu Asn Ala Ala His Lys
     555                 560                 565

 tca gaa aag ttt cga gca atg gcc act cga acg agg cag gag tac ttg     1900
 Ser Glu Lys Phe Arg Ala Met Ala Thr Arg Thr Arg Gln Glu Tyr Leu
 570                 575                 580                 585

 aaa gat ctg gcg gag aac ttt gtc aca acc gcc acc gtg gat acc tct     1948
 Lys Asp Leu Ala Glu Asn Phe Val Thr Thr Ala Thr Val Asp Thr Ser
                 590                 595                 600

 gtg aag ttc agc ttc att acg ctg ggt gcg aag aaa aag gag aag gta     1996
 Val Lys Phe Ser Phe Ile Thr Leu Gly Ala Lys Lys Lys Glu Lys Val
             605                 610                 615

 aag cca agg aag gat gcc cac ttg ttt agc att ggg gcc atc atg tgg     2044
 Lys Pro Arg Lys Asp Ala His Leu Phe Ser Ile Gly Ala Ile Met Trp
         620                 625                 630

 cac gtg ata gcc cgg gac ttc ggc cag tct gct gac att gaa tgt ctt     2092
 His Val Ile Ala Arg Asp Phe Gly Gln Ser Ala Asp Ile Glu Cys Leu
     635                 640                 645

 ctc ggg atc tcc aat gag ttc atc atg ttg att gaa aag gat tcc aag     2140
 Leu Gly Ile Ser Asn Glu Phe Ile Met Leu Ile Glu Lys Asp Ser Lys
 650                 655                 660                 665

 aat gtt gta ttc aac tgt tcc tgc agg gat gtg att ggg tgg aca tct     2188
 Asn Val Val Phe Asn Cys Ser Cys Arg Asp Val Ile Gly Trp Thr Ser
                 670                 675                 680

 gga tta gtg agt atc aaa gtg ttt tac gaa aga gga gaa tgt gtc ctc     2236
 Gly Leu Val Ser Ile Lys Val Phe Tyr Glu Arg Gly Glu Cys Val Leu
             685                 690                 695

 ctg tcc tcg gta gac aac tgt gct gaa gac atc agg gaa att gtt cag     2284
 Leu Ser Ser Val Asp Asn Cys Ala Glu Asp Ile Arg Glu Ile Val Gln
         700                 705                 710

 cga tta gta ata gtg acg aga ggc tgc gag act gtg gaa atg acc ctg     2332
 Arg Leu Val Ile Val Thr Arg Gly Cys Glu Thr Val Glu Met Thr Leu
     715                 720                 725

 agg agg aac ggg ctg ggc cag ctt ggc ttc cat gtg aat ttt gaa gga     2380
 Arg Arg Asn Gly Leu Gly Gln Leu Gly Phe His Val Asn Phe Glu Gly
 730                 735                 740                 745

 att gtc gca gat gtg gaa cct ttt ggc ttt gcc tgg aag gct ggc ctt     2428
 Ile Val Ala Asp Val Glu Pro Phe Gly Phe Ala Trp Lys Ala Gly Leu
                 750                 755                 760

 cgc caa ggg agc cgc ctc gtg gag atc tgc aaa gta gcc gtg gcc act     2476
 Arg Gln Gly Ser Arg Leu Val Glu Ile Cys Lys Val Ala Val Ala Thr
             765                 770                 775

 ctg acc cac gag cag atg atc gac ctg ctc cgt act tct gtg act gtg     2524
 Leu Thr His Glu Gln Met Ile Asp Leu Leu Arg Thr Ser Val Thr Val
         780                 785                 790

 aag gtg gtc atc atc cag ccc cat gat gac ggc tcg ccc cga aga ggg     2572
 Lys Val Val Ile Ile Gln Pro His Asp Asp Gly Ser Pro Arg Arg Gly
     795                 800                 805

 tgt tca gag ctc tgc cgg atc cct atg gtg gaa tat aaa ctc gac agc     2620
 Cys Ser Glu Leu Cys Arg Ile Pro Met Val Glu Tyr Lys Leu Asp Ser
 810                 815                 820                 825

 gag ggc acc ccc tgc gag tat aaa acc ccc ttc agg agg aac act acg     2668
 Glu Gly Thr Pro Cys Glu Tyr Lys Thr Pro Phe Arg Arg Asn Thr Thr
                 830                 835                 840

 tgg cac cgg gtg ccc act cct gcc ctg cag ccc ctc tct aga gct tcc     2716
 Trp His Arg Val Pro Thr Pro Ala Leu Gln Pro Leu Ser Arg Ala Ser
             845                 850                 855

 ccc atc ccc ggc acg ccc gac cgg ctg ccg tgc caa cag ctg ctc cag     2764
 Pro Ile Pro Gly Thr Pro Asp Arg Leu Pro Cys Gln Gln Leu Leu Gln
         860                 865                 870

 cag gcc cag gct gcc att cct cga agc acc tcc ttc gac cgg aag ctg     2812
 Gln Ala Gln Ala Ala Ile Pro Arg Ser Thr Ser Phe Asp Arg Lys Leu
     875                 880                 885

 ccc gat ggc acg aga agc tca ccc agc aac cag tca tcc tcc agc gac     2860
 Pro Asp Gly Thr Arg Ser Ser Pro Ser Asn Gln Ser Ser Ser Ser Asp
 890                 895                 900                 905

 cct gga ccc ggc ggg agc gga ccc tgg aga cca caa gtg ggc tac gac     2908
 Pro Gly Pro Gly Gly Ser Gly Pro Trp Arg Pro Gln Val Gly Tyr Asp
                 910                 915                 920

 ggg tgc cag tcc cct cta ctg ctc gaa cac cag ggc tca ggc cct ttg     2956
 Gly Cys Gln Ser Pro Leu Leu Leu Glu His Gln Gly Ser Gly Pro Leu
             925                 930                 935

 gaa tgt gac gga gcc agg gag agg gaa gac acc atg gaa gca agc agg     3004
 Glu Cys Asp Gly Ala Arg Glu Arg Glu Asp Thr Met Glu Ala Ser Arg
         940                 945                 950

 cac ccg gaa acc aaa tgg cat ggc cca cct tcc aaa gtc ctg ggt tcc     3052
 His Pro Glu Thr Lys Trp His Gly Pro Pro Ser Lys Val Leu Gly Ser
     955                 960                 965

 tat aaa gaa aga gct ctg cag aaa gat gga agt tgc aaa gat tcc ccc     3100
 Tyr Lys Glu Arg Ala Leu Gln Lys Asp Gly Ser Cys Lys Asp Ser Pro
 970                 975                 980                 985

 aat aag ctt tct cac att ggg gat aaa agt tgc tcc agt cac tcc agc     3148
 Asn Lys Leu Ser His Ile Gly Asp Lys Ser Cys Ser Ser His Ser Ser
                 990                 995                1000

 agc aac acg ctc tcc agc aac acc tcc agc aac agt gac gac aag cac     3196
 Ser Asn Thr Leu Ser Ser Asn Thr Ser Ser Asn Ser Asp Asp Lys His
            1005                1010                1015

 ttt ggg tct ggc gac ctg atg gac ccc gaa tta ctg ggg ctg acc tac     3244
 Phe Gly Ser Gly Asp Leu Met Asp Pro Glu Leu Leu Gly Leu Thr Tyr
        1020                1025                1030

 atc aaa ggg gcc tcc acc gac agt gac atc gac acg gcc ccc tgc atg     3292
 Ile Lys Gly Ala Ser Thr Asp Ser Asp Ile Asp Thr Ala Pro Cys Met
    1035                1040                1045

 cct gcc acc atc ctc ggc cct gtg cac ctg gca ggc agc agg tcc ctg     3340
 Pro Ala Thr Ile Leu Gly Pro Val His Leu Ala Gly Ser Arg Ser Leu
1050                1055                1060                1065

 atc cac agc cgg gcc gag cag tgg gct gat gct gcc gac gtc tct ggg     3388
 Ile His Ser Arg Ala Glu Gln Trp Ala Asp Ala Ala Asp Val Ser Gly
                1070                1075                1080

 cct gac gac gag cca gcc aag tta tat tct gtg cat ggc tac gcg tcc     3436
 Pro Asp Asp Glu Pro Ala Lys Leu Tyr Ser Val His Gly Tyr Ala Ser
            1085                1090                1095

 gcc atc tcc gcc ggc agt gct gcg gaa ggc agc atg ggc gat ctc agt     3484
 Ala Ile Ser Ala Gly Ser Ala Ala Glu Gly Ser Met Gly Asp Leu Ser
        1100                1105                1110

 gag ata tcc tct cat tcc agt ggt tct cac cat tca gga agc cct tca     3532
 Glu Ile Ser Ser His Ser Ser Gly Ser His His Ser Gly Ser Pro Ser
    1115                1120                1125

 gct cac tgt tca aaa agt agt ggg tct ctg gat tca tcc aaa gtc tac     3580
 Ala His Cys Ser Lys Ser Ser Gly Ser Leu Asp Ser Ser Lys Val Tyr
1130                1135                1140                1145

 atc gtg tct cac agc agc gga caa cag gtt ccc ggg tcc atg tcc aag     3628
 Ile Val Ser His Ser Ser Gly Gln Gln Val Pro Gly Ser Met Ser Lys
                1150                1155                1160

 ccc tac cac aga caa ggg gca gtg aac aaa tat gtc atc ggc tgg aag     3676
 Pro Tyr His Arg Gln Gly Ala Val Asn Lys Tyr Val Ile Gly Trp Lys
            1165                1170                1175

 aaa tcg gag ggc agc cca ccg ccc gag gag cct gaa gtg act gaa tgt     3724
 Lys Ser Glu Gly Ser Pro Pro Pro Glu Glu Pro Glu Val Thr Glu Cys
        1180                1185                1190

 ccc ggg atg tat agt gag atg gat gtc atg tcc aca gca act cag cat     3772
 Pro Gly Met Tyr Ser Glu Met Asp Val Met Ser Thr Ala Thr Gln His
    1195                1200                1205

 cag aca gtg gtg gga gat gct gtt gca gag act caa cat gtt ctg tct     3820
 Gln Thr Val Val Gly Asp Ala Val Ala Glu Thr Gln His Val Leu Ser
1210                1215                1220                1225

 aaa gaa gat ttt ctg aaa ttg atg ctt cct gac agc ccc tta gtg gag     3868
 Lys Glu Asp Phe Leu Lys Leu Met Leu Pro Asp Ser Pro Leu Val Glu
                1230                1235                1240

 gag ggg cga aga aag ttt tcg ttc tat ggg aac ctg tct cca agg agg     3916
 Glu Gly Arg Arg Lys Phe Ser Phe Tyr Gly Asn Leu Ser Pro Arg Arg
            1245                1250                1255

 tcg ctt tac cgc acg ctg tct gac gag agc atc tgc agc aac agg agg     3964
 Ser Leu Tyr Arg Thr Leu Ser Asp Glu Ser Ile Cys Ser Asn Arg Arg
        1260                1265                1270

 ggg tcc tcc ttt ggc agt tcc cgg agt tcc gtg ctt gac cag gcc ctg     4012
 Gly Ser Ser Phe Gly Ser Ser Arg Ser Ser Val Leu Asp Gln Ala Leu
    1275                1280                1285

 ccc aac gac att ctg ttc agc acc acc cca ccc tac cac agc acg ctg     4060
 Pro Asn Asp Ile Leu Phe Ser Thr Thr Pro Pro Tyr His Ser Thr Leu
1290                1295                1300                1305

 cct ccg cgg gcc cac ccc gca ccc agc atg ggg agc ctg aga aat gag     4108
 Pro Pro Arg Ala His Pro Ala Pro Ser Met Gly Ser Leu Arg Asn Glu
                1310                1315                1320

 ttc tgg ttc tcc gat ggg tcc tta tca gat aag tcc aag tgc gca gat     4156
 Phe Trp Phe Ser Asp Gly Ser Leu Ser Asp Lys Ser Lys Cys Ala Asp
            1325                1330                1335

 cct ggc ctg atg ccc ctc ccg gac aca gcc aca ggg tta gat tgg acc     4204
 Pro Gly Leu Met Pro Leu Pro Asp Thr Ala Thr Gly Leu Asp Trp Thr
        1340                1345                1350

 cac ctc gtg gat gct gca cgg gca ttt gaa ggt ctt gac tca gat gaa     4252
 His Leu Val Asp Ala Ala Arg Ala Phe Glu Gly Leu Asp Ser Asp Glu
    1355                1360                1365

 gaa ctg ggg ctg ctc tgt cac cac acg tcc tat cta gac cag agg gtg     4300
 Glu Leu Gly Leu Leu Cys His His Thr Ser Tyr Leu Asp Gln Arg Val
1370                1375                1380                1385

 gca tcc ttc tgc acc ctg aca gat atg cag cat ggg cag gac ctg gaa     4348
 Ala Ser Phe Cys Thr Leu Thr Asp Met Gln His Gly Gln Asp Leu Glu
                1390                1395                1400

 ggg gcc caa gag ctg ccc tta tgt gta gat cca ggc agt ggc aaa gag     4396
 Gly Ala Gln Glu Leu Pro Leu Cys Val Asp Pro Gly Ser Gly Lys Glu
            1405                1410                1415

 ttc atg gac aca act ggg gag cgt tct cca tca cca ctg acc ggg aaa     4444
 Phe Met Asp Thr Thr Gly Glu Arg Ser Pro Ser Pro Leu Thr Gly Lys
        1420                1425                1430

 gtc aat cag ctg gaa tta att ctt cga caa ctc cag acc gac ctt cgg     4492
 Val Asn Gln Leu Glu Leu Ile Leu Arg Gln Leu Gln Thr Asp Leu Arg
    1435                1440                1445

 aag gaa aaa caa gac aag gcc gtt ctc caa gca gaa gtg cag cac ctg     4540
 Lys Glu Lys Gln Asp Lys Ala Val Leu Gln Ala Glu Val Gln His Leu
1450                1455                1460                1465

 aga cag gac aac atg aga ctg cag gag gag tcc cag acc gcg aca gct     4588
 Arg Gln Asp Asn Met Arg Leu Gln Glu Glu Ser Gln Thr Ala Thr Ala
                1470                1475                1480

 cag ctg cgg aaa ttc aca gaa tgg ttt ttc acc acc atc gac aaa aaa     4636
 Gln Leu Arg Lys Phe Thr Glu Trp Phe Phe Thr Thr Ile Asp Lys Lys
            1485                1490                1495

 tct tag ccaatccgca cctcatcaag ggaccactgg gaaatgcccc ttgtcccttt      4692
 Ser 






      <210> 20
      <211> 5153
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(4588)

      <400> 20
 caggcaaggc ttatctggtg aaaacttttt tgctatgctc agagggtacc gagtagaaaa     60

 ttatgaccca aaagggacca ttgctttgtg gtcataattt tctactcggt accctctgag    120

 catagcaaat tatgaccaca aagca  atg gtc cct ttt ggg ttc cct gaa ttt     172
                              Met Val Pro Phe Gly Phe Pro Glu Phe
                                1               5

 ttc cgc tgt gac cct gca atc tct ccg agc ctt cat gca gca gca cag      220
 Phe Arg Cys Asp Pro Ala Ile Ser Pro Ser Leu His Ala Ala Ala Gln
  10                  15                  20                  25

 att tct agg gga gaa ttt gtc cgc atc tca gga tta gat tat gtg gac      268
 Ile Ser Arg Gly Glu Phe Val Arg Ile Ser Gly Leu Asp Tyr Val Asp
                  30                  35                  40

 agt gcc ctc ctg atg ggg aga gac agg gac aag cct ttc aaa cgg agg      316
 Ser Ala Leu Leu Met Gly Arg Asp Arg Asp Lys Pro Phe Lys Arg Arg
              45                  50                  55

 ttg aaa tca gag tcg gtg gaa aca tct ctc ttc cga aag ctt cga act      364
 Leu Lys Ser Glu Ser Val Glu Thr Ser Leu Phe Arg Lys Leu Arg Thr
          60                  65                  70

 gtt aaa agt gag cac gaa act ttc aag ttc acg tct gag ctg gag gag      412
 Val Lys Ser Glu His Glu Thr Phe Lys Phe Thr Ser Glu Leu Glu Glu
      75                  80                  85

 agc cga ctg gag agg ggc att cgc cct tgg aat tgt cag cga tgt ttt      460
 Ser Arg Leu Glu Arg Gly Ile Arg Pro Trp Asn Cys Gln Arg Cys Phe
  90                  95                 100                 105

 gca cat tat gat gtc cag agc att ttg ttt aat atc aac gaa gcc atg      508
 Ala His Tyr Asp Val Gln Ser Ile Leu Phe Asn Ile Asn Glu Ala Met
                 110                 115                 120

 gct acg agg gct aat gtg ggg aaa agg aaa aac ata acc act ggg gca      556
 Ala Thr Arg Ala Asn Val Gly Lys Arg Lys Asn Ile Thr Thr Gly Ala
             125                 130                 135

 tct gca gca tcc cag act cag atg cct acg ggc cag aca ggc aac tgt      604
 Ser Ala Ala Ser Gln Thr Gln Met Pro Thr Gly Gln Thr Gly Asn Cys
         140                 145                 150

 gag tcc cct tta ggg agc aag gag gac ctc aac tcc aaa gag aac ctg      652
 Glu Ser Pro Leu Gly Ser Lys Glu Asp Leu Asn Ser Lys Glu Asn Leu
     155                 160                 165

 gat gcc gat gag ggt gat ggg aaa agt aac gac ctc gtc ctt agt tgt      700
 Asp Ala Asp Glu Gly Asp Gly Lys Ser Asn Asp Leu Val Leu Ser Cys
 170                 175                 180                 185

 cct tac ttt aga aat gag act gga ggg gaa ggc gac agg cgg att gcg      748
 Pro Tyr Phe Arg Asn Glu Thr Gly Gly Glu Gly Asp Arg Arg Ile Ala
                 190                 195                 200

 ctc tct cga gcc aac tca tcc tct ttc agt tct ggg gaa agc tgc tct      796
 Leu Ser Arg Ala Asn Ser Ser Ser Phe Ser Ser Gly Glu Ser Cys Ser
             205                 210                 215

 ttc gaa tcg tca ctc agc tct cac tgc aca aat gca ggt gtc tcc gtc      844
 Phe Glu Ser Ser Leu Ser Ser His Cys Thr Asn Ala Gly Val Ser Val
         220                 225                 230

 ttg gaa gtg ccc aga gaa aac cag cct att cac agg gag aaa gtg aag      892
 Leu Glu Val Pro Arg Glu Asn Gln Pro Ile His Arg Glu Lys Val Lys
     235                 240                 245

 cgc tac atc ata gaa cac att gac ctt ggg gcc tat tat tac cgc aaa      940
 Arg Tyr Ile Ile Glu His Ile Asp Leu Gly Ala Tyr Tyr Tyr Arg Lys
 250                 255                 260                 265

 ttc ttc tat ggg aaa gag cac caa aac tac ttt gga ata gat gaa aac      988
 Phe Phe Tyr Gly Lys Glu His Gln Asn Tyr Phe Gly Ile Asp Glu Asn
                 270                 275                 280

 ctt ggt cca gta gca gtc agc atc cgg aga gag aag gtg gaa gat gcc     1036
 Leu Gly Pro Val Ala Val Ser Ile Arg Arg Glu Lys Val Glu Asp Ala
             285                 290                 295

 aag gag aaa gaa gga tcc cag ttc aac tac agg gtg gct ttc agg aca     1084
 Lys Glu Lys Glu Gly Ser Gln Phe Asn Tyr Arg Val Ala Phe Arg Thr
         300                 305                 310

 agt gag ctt aca aca ctg aga gga gca att tta gaa gat gct ata ccc     1132
 Ser Glu Leu Thr Thr Leu Arg Gly Ala Ile Leu Glu Asp Ala Ile Pro
     315                 320                 325

 tct act gct agg cat ggt acc gca cga gga cta cct ctc aaa gaa gtt     1180
 Ser Thr Ala Arg His Gly Thr Ala Arg Gly Leu Pro Leu Lys Glu Val
 330                 335                 340                 345

 ttg gaa tac gtc att cca gag ctg agc att cag tgt ttg cga cag gct     1228
 Leu Glu Tyr Val Ile Pro Glu Leu Ser Ile Gln Cys Leu Arg Gln Ala
                 350                 355                 360

 tcc aac tca ccc aag gtc tca gag cag ctg ctc aag ctt gat gaa caa     1276
 Ser Asn Ser Pro Lys Val Ser Glu Gln Leu Leu Lys Leu Asp Glu Gln
             365                 370                 375

 ggg ctg agc ttt cag cac aag atc ggg atc ctt tat tgc aaa gca ggc     1324
 Gly Leu Ser Phe Gln His Lys Ile Gly Ile Leu Tyr Cys Lys Ala Gly
         380                 385                 390

 cag agc aca gag gaa gag atg tat aac aat gag acg gcg gga cca gct     1372
 Gln Ser Thr Glu Glu Glu Met Tyr Asn Asn Glu Thr Ala Gly Pro Ala
     395                 400                 405

 ttt gaa gaa ttc ctt gat ctt ctg ggc cag aga gtc cga ctg aaa gga     1420
 Phe Glu Glu Phe Leu Asp Leu Leu Gly Gln Arg Val Arg Leu Lys Gly
 410                 415                 420                 425

 ttt agt aaa tat cga gct cag cta gac aat aag act gat tcc acg ggc     1468
 Phe Ser Lys Tyr Arg Ala Gln Leu Asp Asn Lys Thr Asp Ser Thr Gly
                 430                 435                 440

 acg cac tct ctc tat acc aca tac aaa gac tac gaa ctc atg ttc cac     1516
 Thr His Ser Leu Tyr Thr Thr Tyr Lys Asp Tyr Glu Leu Met Phe His
             445                 450                 455

 gtg tca acc ctg ctt ccc tac atg ccc aac aac aga caa cag cta ctg     1564
 Val Ser Thr Leu Leu Pro Tyr Met Pro Asn Asn Arg Gln Gln Leu Leu
         460                 465                 470

 agg aaa agg cac ata gga aat gac atc gtc acc atc gtc ttc cag gag     1612
 Arg Lys Arg His Ile Gly Asn Asp Ile Val Thr Ile Val Phe Gln Glu
     475                 480                 485

 cct ggg gca ctt cct ttt act cca aaa agc atc cgg tct cac ttt cag     1660
 Pro Gly Ala Leu Pro Phe Thr Pro Lys Ser Ile Arg Ser His Phe Gln
 490                 495                 500                 505

 cat gtc ttt gtc ata gtc aaa gtg cat aat cca tgt acc gaa aat gtg     1708
 His Val Phe Val Ile Val Lys Val His Asn Pro Cys Thr Glu Asn Val
                 510                 515                 520

 tgt tat agt gtt gga gtt tcc aga tca aaa gat gtg cca cca ttt ggc     1756
 Cys Tyr Ser Val Gly Val Ser Arg Ser Lys Asp Val Pro Pro Phe Gly
             525                 530                 535

 cca ccg att ccc aaa ggt gta act ttt cca aag tca gcc gtg ttc cgg     1804
 Pro Pro Ile Pro Lys Gly Val Thr Phe Pro Lys Ser Ala Val Phe Arg
         540                 545                 550

 gac ttc ctt tta gcc aaa gta atc aat gca gaa aat gca gcc cat aaa     1852
 Asp Phe Leu Leu Ala Lys Val Ile Asn Ala Glu Asn Ala Ala His Lys
     555                 560                 565

 tca gaa aag ttt cga gca atg gcc act cga acg agg cag gag tac ttg     1900
 Ser Glu Lys Phe Arg Ala Met Ala Thr Arg Thr Arg Gln Glu Tyr Leu
 570                 575                 580                 585

 aaa gat ctg gcg gag aac ttt gtc aca acc gcc acc gtg gat acc tct     1948
 Lys Asp Leu Ala Glu Asn Phe Val Thr Thr Ala Thr Val Asp Thr Ser
                 590                 595                 600

 gtg aag ttc agc ttc att acg ctg ggt gcg aag aaa aag gag aag gta     1996
 Val Lys Phe Ser Phe Ile Thr Leu Gly Ala Lys Lys Lys Glu Lys Val
             605                 610                 615

 aag cca agg aag gat gcc cac ttg ttt agc att ggg gcc atc atg tgg     2044
 Lys Pro Arg Lys Asp Ala His Leu Phe Ser Ile Gly Ala Ile Met Trp
         620                 625                 630

 cac gtg ata gcc cgg gac ttc ggc cag tct gct gac att gaa tgt ctt     2092
 His Val Ile Ala Arg Asp Phe Gly Gln Ser Ala Asp Ile Glu Cys Leu
     635                 640                 645

 ctc ggg atc tcc aat gag ttc atc atg ttg att gaa aag gat tcc aag     2140
 Leu Gly Ile Ser Asn Glu Phe Ile Met Leu Ile Glu Lys Asp Ser Lys
 650                 655                 660                 665

 aat gtt gta ttc aac tgt tcc tgc agg gat gtg att ggg tgg aca tct     2188
 Asn Val Val Phe Asn Cys Ser Cys Arg Asp Val Ile Gly Trp Thr Ser
                 670                 675                 680

 gga tta gtg agt atc aaa gtg ttt tac gaa aga gga gaa tgt gtc ctc     2236
 Gly Leu Val Ser Ile Lys Val Phe Tyr Glu Arg Gly Glu Cys Val Leu
             685                 690                 695

 ctg tcc tcg gta gac aac tgt gct gaa gac atc agg gaa att gtt cag     2284
 Leu Ser Ser Val Asp Asn Cys Ala Glu Asp Ile Arg Glu Ile Val Gln
         700                 705                 710

 cga tta gta ata gtg acg aga ggc tgc gag act gtg gaa atg acc ctg     2332
 Arg Leu Val Ile Val Thr Arg Gly Cys Glu Thr Val Glu Met Thr Leu
     715                 720                 725

 agg agg aac ggg ctg ggc cag ctt ggc ttc cat gtg aat ttt gaa gga     2380
 Arg Arg Asn Gly Leu Gly Gln Leu Gly Phe His Val Asn Phe Glu Gly
 730                 735                 740                 745

 att gtc gca gat gtg gaa cct ttt ggc ttt gcc tgg aag gct ggc ctt     2428
 Ile Val Ala Asp Val Glu Pro Phe Gly Phe Ala Trp Lys Ala Gly Leu
                 750                 755                 760

 cgc caa ggg agc cgc ctc gtg gag atc tgc aaa gta gcc gtg gcc act     2476
 Arg Gln Gly Ser Arg Leu Val Glu Ile Cys Lys Val Ala Val Ala Thr
             765                 770                 775

 ctg acc cac gag cag atg atc gac ctg ctc cgt act tct gtg act gtg     2524
 Leu Thr His Glu Gln Met Ile Asp Leu Leu Arg Thr Ser Val Thr Val
         780                 785                 790

 aag gtg gtc atc atc cag ccc cat gat gac ggc tcg ccc cga aga ggg     2572
 Lys Val Val Ile Ile Gln Pro His Asp Asp Gly Ser Pro Arg Arg Gly
     795                 800                 805

 tgt tca gag ctc tgc cgg atc cct atg gtg gaa tat aaa ctc gac agc     2620
 Cys Ser Glu Leu Cys Arg Ile Pro Met Val Glu Tyr Lys Leu Asp Ser
 810                 815                 820                 825

 gag ggc acc ccc tgc gag tat aaa acc ccc ttc agg agg aac act acg     2668
 Glu Gly Thr Pro Cys Glu Tyr Lys Thr Pro Phe Arg Arg Asn Thr Thr
                 830                 835                 840

 tgg cac cgg gtg ccc act cct gcc ctg cag ccc ctc tct aga gct tcc     2716
 Trp His Arg Val Pro Thr Pro Ala Leu Gln Pro Leu Ser Arg Ala Ser
             845                 850                 855

 ccc atc ccc ggc acg ccc gac cgg ctg ccg tgc caa cag ctg ctc cag     2764
 Pro Ile Pro Gly Thr Pro Asp Arg Leu Pro Cys Gln Gln Leu Leu Gln
         860                 865                 870

 cag gcc cag gct gcc att cct cga agc acc tcc ttc gac cgg aag ctg     2812
 Gln Ala Gln Ala Ala Ile Pro Arg Ser Thr Ser Phe Asp Arg Lys Leu
     875                 880                 885

 ccc gat ggc acg aga agc tca ccc agc aac cag tca tcc tcc agc gac     2860
 Pro Asp Gly Thr Arg Ser Ser Pro Ser Asn Gln Ser Ser Ser Ser Asp
 890                 895                 900                 905

 cct gga ccc ggc ggg agc gga ccc tgg aga cca caa gtg ggc tac gac     2908
 Pro Gly Pro Gly Gly Ser Gly Pro Trp Arg Pro Gln Val Gly Tyr Asp
                 910                 915                 920

 ggg tgc cag tcc cct cta ctg ctc gaa cac cag ggc tca ggc cct ttg     2956
 Gly Cys Gln Ser Pro Leu Leu Leu Glu His Gln Gly Ser Gly Pro Leu
             925                 930                 935

 gaa tgt gac gga gcc agg gag agg gaa gac acc atg gaa gca agc agg     3004
 Glu Cys Asp Gly Ala Arg Glu Arg Glu Asp Thr Met Glu Ala Ser Arg
         940                 945                 950

 cac ccg gaa acc aaa tgg cat ggc cca cct tcc aaa gtc ctg ggt tcc     3052
 His Pro Glu Thr Lys Trp His Gly Pro Pro Ser Lys Val Leu Gly Ser
     955                 960                 965

 tat aaa gaa aga gct ctg cag aaa gat gga agt tgc aaa gat tcc ccc     3100
 Tyr Lys Glu Arg Ala Leu Gln Lys Asp Gly Ser Cys Lys Asp Ser Pro
 970                 975                 980                 985

 aat aag ctt tct cac att ggg gat aaa agt tgc tcc agt cac tcc agc     3148
 Asn Lys Leu Ser His Ile Gly Asp Lys Ser Cys Ser Ser His Ser Ser
                 990                 995                1000

 agc aac acg ctc tcc agc aac acc tcc agc aac agt gac gac aag cac     3196
 Ser Asn Thr Leu Ser Ser Asn Thr Ser Ser Asn Ser Asp Asp Lys His
            1005                1010                1015

 ttt ggg tct ggc gac ctg atg gac ccc gaa tta ctg ggg ctg acc tac     3244
 Phe Gly Ser Gly Asp Leu Met Asp Pro Glu Leu Leu Gly Leu Thr Tyr
        1020                1025                1030

 atc aaa ggg gcc tcc acc gac agt gac atc gac acg gcc ccc tgc atg     3292
 Ile Lys Gly Ala Ser Thr Asp Ser Asp Ile Asp Thr Ala Pro Cys Met
    1035                1040                1045

 cct gcc acc atc ctc ggc cct gtg cac ctg gca ggc agc agg tcc ctg     3340
 Pro Ala Thr Ile Leu Gly Pro Val His Leu Ala Gly Ser Arg Ser Leu
1050                1055                1060                1065

 atc cac agc cgg gcc gag cag tgg gct gat gct gcc gac gtc tct ggg     3388
 Ile His Ser Arg Ala Glu Gln Trp Ala Asp Ala Ala Asp Val Ser Gly
                1070                1075                1080

 cct gac gac gag cca gcc aag tta tat tct gtg cat ggc tac gcg tcc     3436
 Pro Asp Asp Glu Pro Ala Lys Leu Tyr Ser Val His Gly Tyr Ala Ser
            1085                1090                1095

 gcc atc tcc gcc ggc agt gct gcg gaa ggc agc atg ggc gat ctc agt     3484
 Ala Ile Ser Ala Gly Ser Ala Ala Glu Gly Ser Met Gly Asp Leu Ser
        1100                1105                1110

 gag ata tcc tct cat tcc agt ggt tct cac cat tca gga agc cct tca     3532
 Glu Ile Ser Ser His Ser Ser Gly Ser His His Ser Gly Ser Pro Ser
    1115                1120                1125

 gct cac tgt tca aaa agt agt ggg tct ctg gat tca tcc aaa gtc tac     3580
 Ala His Cys Ser Lys Ser Ser Gly Ser Leu Asp Ser Ser Lys Val Tyr
1130                1135                1140                1145

 atc gtg tct cac agc agc gga caa cag gtt ccc ggg tcc atg tcc aag     3628
 Ile Val Ser His Ser Ser Gly Gln Gln Val Pro Gly Ser Met Ser Lys
                1150                1155                1160

 ccc tac cac aga caa ggg gca gtg aac aaa tat gtc atc ggc tgg aag     3676
 Pro Tyr His Arg Gln Gly Ala Val Asn Lys Tyr Val Ile Gly Trp Lys
            1165                1170                1175

 aaa tcg gag ggc agc cca ccg ccc gag gag cct gaa gtg act gaa tgt     3724
 Lys Ser Glu Gly Ser Pro Pro Pro Glu Glu Pro Glu Val Thr Glu Cys
        1180                1185                1190

 ccc ggg atg tat agt gag atg gat gtc atg tcc aca gca act cag cat     3772
 Pro Gly Met Tyr Ser Glu Met Asp Val Met Ser Thr Ala Thr Gln His
    1195                1200                1205

 cag aca gtg gtg gga gat gct gtt gca gag act caa cat gtt ctg tct     3820
 Gln Thr Val Val Gly Asp Ala Val Ala Glu Thr Gln His Val Leu Ser
1210                1215                1220                1225

 aaa gaa gat ttt ctg aaa ttg atg ctt cct gac agc ccc tta gtg gag     3868
 Lys Glu Asp Phe Leu Lys Leu Met Leu Pro Asp Ser Pro Leu Val Glu
                1230                1235                1240

 gag ggg cga aga aag ttt tcg ttc tat ggg aac ctg tct cca agg agg     3916
 Glu Gly Arg Arg Lys Phe Ser Phe Tyr Gly Asn Leu Ser Pro Arg Arg
            1245                1250                1255

 tcg ctt tac cgc acg ctg tct gac gag agc atc tgc agc aac agg agg     3964
 Ser Leu Tyr Arg Thr Leu Ser Asp Glu Ser Ile Cys Ser Asn Arg Arg
        1260                1265                1270

 ggg tcc tcc ttt ggc agt tcc cgg agt tcc gtg ctt gac cag gcc ctg     4012
 Gly Ser Ser Phe Gly Ser Ser Arg Ser Ser Val Leu Asp Gln Ala Leu
    1275                1280                1285

 ccc aac gac att ctg ttc agc acc acc cca ccc tac cac agc acg ctg     4060
 Pro Asn Asp Ile Leu Phe Ser Thr Thr Pro Pro Tyr His Ser Thr Leu
1290                1295                1300                1305

 cct ccg cgg gcc cac ccc gca ccc agc atg ggg agc ctg aga aat gag     4108
 Pro Pro Arg Ala His Pro Ala Pro Ser Met Gly Ser Leu Arg Asn Glu
                1310                1315                1320

 ttc tgg ttc tcc gat ggg tcc tta tca gat aag tcc aag tgc gca gat     4156
 Phe Trp Phe Ser Asp Gly Ser Leu Ser Asp Lys Ser Lys Cys Ala Asp
            1325                1330                1335

 cct ggc ctg atg ccc ctc ccg gac aca gcc aca ggg tta gat tgg acc     4204
 Pro Gly Leu Met Pro Leu Pro Asp Thr Ala Thr Gly Leu Asp Trp Thr
        1340                1345                1350

 cac ctc gtg gat gct gca cgg gca ttt gaa gac cag agg gtg gca tcc     4252
 His Leu Val Asp Ala Ala Arg Ala Phe Glu Asp Gln Arg Val Ala Ser
    1355                1360                1365

 ttc tgc acc ctg aca gat atg cag cat ggg cag gac ctg gaa ggg gcc     4300
 Phe Cys Thr Leu Thr Asp Met Gln His Gly Gln Asp Leu Glu Gly Ala
1370                1375                1380                1385

 caa gag ctg ccc tta tgt gta gat cca ggc agt ggc aaa gag ttc atg     4348
 Gln Glu Leu Pro Leu Cys Val Asp Pro Gly Ser Gly Lys Glu Phe Met
                1390                1395                1400

 gac aca act ggg gag cgt tct cca tca cca ctg acc ggg aaa gtc aat     4396
 Asp Thr Thr Gly Glu Arg Ser Pro Ser Pro Leu Thr Gly Lys Val Asn
            1405                1410                1415

 cag ctg gaa tta att ctt cga caa ctc cag acc gac ctt cgg aag gaa     4444
 Gln Leu Glu Leu Ile Leu Arg Gln Leu Gln Thr Asp Leu Arg Lys Glu
        1420                1425                1430

 aaa caa gac aag gcc gtt ctc caa gca gaa gtg cag cac ctg aga cag     4492
 Lys Gln Asp Lys Ala Val Leu Gln Ala Glu Val Gln His Leu Arg Gln
    1435                1440                1445

 gac aac atg aga ctg cag gag gag tcc cag acc gcg aca gct cag ctg     4540
 Asp Asn Met Arg Leu Gln Glu Glu Ser Gln Thr Ala Thr Ala Gln Leu
1450                1455                1460                1465

 cgg aaa ttc aca gaa tgg ttt ttc acc acc atc gac aaa aaa tct tag     4588
 Arg Lys Phe Thr Glu Trp Phe Phe Thr Thr Ile Asp Lys Lys Ser 
                1470                1475                1480

 ccaatccgca cctcatcaag ggaccactgg gaaatgcccc ttgtcccttt gaagtcacaa   4648

 acatgtggtt tttctgtgtg ctttcaacca atcgtagatg tttttgctgt tccattctgt   4708

 gtagcaccat tcaccacagc aggataggga gcctcgactc tttctcggta accacggcag   4768

 agagcagcgc cgatgtgaag atgaatgaat gtaactcctg gtgtgaagat gaatgtaaac   4828

 cctggcgaca gttgagacct ttttctttta gactctgcta aaacagtgct ctggcttggg   4888

 cttacctcaa gagggaagat agttgagttt tatttcctgt atatcaggtg acctggtaga   4948

 gatgtaaagc aatttaccat agtttgggct ttagtattgt aaaataaaca tgagaacaaa   5008

 taatcagaca tatactttaa tgttaaaggt gctctatttt tttggatgta cagtagtttt   5068

 atttccacag ccacattacc atagcaataa gaaaggaggc atagtacata gttggaaaag   5128

 ctttgtgggg ggattaaaaa aaaaa                                         5153




      <210> 21
      <211> 2244
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(981)

      <400> 21
 ctggccaagg tatagaaagc cttttagtca aatcattctt tggtttggtg agagatataa     60

 aggtatacat actgtcatta gtgtactgcc taaaaataat atcgattctt ttcctctcca    120

 gaggctggaa gtcatccaca acaaacacaa aaattggaag aaattaaaga gaatgcacag    180

 gacacc   atg aga cag att aat aaa aag ggt ttt tgg agc tat ggc cct     228
          Met Arg Gln Ile Asn Lys Lys Gly Phe Trp Ser Tyr Gly Pro
            1               5                  10

 gtg att ctt gtc gtc ctg gtt gtg gct gtt gtg gca agt tct gtg aat      276
 Val Ile Leu Val Val Leu Val Val Ala Val Val Ala Ser Ser Val Asn
  15                  20                  25                  30

 agc tac tat tcc tct cca gcc cag caa gtg ccc aaa aat cca gct ttg      324
 Ser Tyr Tyr Ser Ser Pro Ala Gln Gln Val Pro Lys Asn Pro Ala Leu
                  35                  40                  45

 gag gcc ttt ttg gcc cag ttt agc caa ttg gaa gat aaa ttt cca ggc      372
 Glu Ala Phe Leu Ala Gln Phe Ser Gln Leu Glu Asp Lys Phe Pro Gly
              50                  55                  60

 cag agt tcc ttc ctg tgg cag aga gga cgg aag ttt ctc cag aag cac      420
 Gln Ser Ser Phe Leu Trp Gln Arg Gly Arg Lys Phe Leu Gln Lys His
          65                  70                  75

 ctc aat gct tcc aac ccc act gag cca gcc acc atc ata ttt aca gca      468
 Leu Asn Ala Ser Asn Pro Thr Glu Pro Ala Thr Ile Ile Phe Thr Ala
      80                  85                  90

 gct cgg gag gga aga gag acc ctg aag tgc ctg agc cac cat gtt gca      516
 Ala Arg Glu Gly Arg Glu Thr Leu Lys Cys Leu Ser His His Val Ala
  95                 100                 105                 110

 gat gcc tac acc tct tcc cag aaa gtc tct ccc att cag att gat ggg      564
 Asp Ala Tyr Thr Ser Ser Gln Lys Val Ser Pro Ile Gln Ile Asp Gly
                 115                 120                 125

 gct gga agg acc tgg cag gac agt gac acg gtc aag ctg ttg gtt gac      612
 Ala Gly Arg Thr Trp Gln Asp Ser Asp Thr Val Lys Leu Leu Val Asp
             130                 135                 140

 ctg gag ctg agc tat ggg ttt gag aat ggc cag aag gct gct gtg gta      660
 Leu Glu Leu Ser Tyr Gly Phe Glu Asn Gly Gln Lys Ala Ala Val Val
         145                 150                 155

 cac cac ttc gaa tcc ttc cct gcc ggc tcc act ttg atc ttc tat aag      708
 His His Phe Glu Ser Phe Pro Ala Gly Ser Thr Leu Ile Phe Tyr Lys
     160                 165                 170

 tat tgt gat cat gag aat gct gcc ttt aaa gat gtg gcc ctg gtc ctg      756
 Tyr Cys Asp His Glu Asn Ala Ala Phe Lys Asp Val Ala Leu Val Leu
 175                 180                 185                 190

 act gtt ctg cta gag gag gaa aca tta gaa gca agt gta ggc cca agg      804
 Thr Val Leu Leu Glu Glu Glu Thr Leu Glu Ala Ser Val Gly Pro Arg
                 195                 200                 205

 gaa acg gaa gaa aaa gtg aga gac tta ctc tgg gcc aag ttt acc aac      852
 Glu Thr Glu Glu Lys Val Arg Asp Leu Leu Trp Ala Lys Phe Thr Asn
             210                 215                 220

 tct gac act ccc acc tcc ttc aac cac atg gac tca gac aaa ttg agt      900
 Ser Asp Thr Pro Thr Ser Phe Asn His Met Asp Ser Asp Lys Leu Ser
         225                 230                 235

 ggg ctg tgg agc cga att tca cac ctg gta ctg cca gtc cag cca gtg      948
 Gly Leu Trp Ser Arg Ile Ser His Leu Val Leu Pro Val Gln Pro Val
     240                 245                 250

 agt agc ata gaa gaa cag ggg tgc ctt ttc taa agctaagc acagagttgg      999
 Ser Ser Ile Glu Glu Gln Gly Cys Leu Phe 
 255                 260

 ttacagaagg tatatgttta tgaaaaagtt tgtttaaaga ccttccattt atatggaagg   1059

 aggttgataa aatagcttga ggaaatagcc tgaaaaacaa agatgagctt attttagaaa   1119

 caagttttta ttttttattc cttgtaaaat ctttctaatc taagccttga caaagctaaa   1179

 aattaacctg actttttttc tttggaccaa atcaggtttg aaatatcgat gatatatatg   1239

 agaatttttt ttaaattcta aaatatagca acattgcaca ggaagatact cttacttctt   1299

 agagtaacta cagagtgatt tttttttttt cttgagggag actctgaaaa accttttcga   1359

 taatgtttgg acttggacta aagcaattag aattatgaag caatgataac ctttaaaaaa   1419

 tttttctatc acatgttgaa tattttcaaa ccttacttta ataatctaaa gttacgggat   1479

 tatatcttat attaattttg cagttttgag tagtatgata aaagaaataa gaattcaaac   1539

 cattaagtac ctacctaaat actacatgta aggcactgtg cttttatttc attcagctga   1599

 ggtataagca gctgtactca aatgttctta aaaatgagaa ccagtgggga aattgtttat   1659

 aatcattgga aatgaagaaa ttccaattgg ctatatcttt acttcagctt ttcttgaaca   1719

 atttacagca ttgattttca aactgtgtct actggcaccc ttcccctttg tatcagagca   1779

 gttctgcttt taactgtttt atatgttggg gttctctatg agatttcatt ggaacaaaga   1839

 gtttcactga tattcgagtt tgaaaaccat tgattaagtg aaaaaacatc ttagaagata   1899

 ggaaatatgt ttaaaaaatg aatgtattaa atcttatgag taggaagatg aaatacaggt   1959

 ttattgtata gatacattat ttatgaagga taaagatcta tacatgaaca gcagaatgta   2019

 taagctagca tttactagca tgtctctgat gcttttgttc atttctgtta atcgtcattt   2079

 ctgtcccctc tgcatggaat tttatacttg tctagggtaa gagtttgtag actctttcag   2139

 cagaacagat tttaataacc aatttatttg ttttatttta aaaatttatt tttgaataac   2199

 caatttaata gtaaatttta tatgaacatt tggcaaaaaa aaaaa                   2244




      <210> 22
      <211> 1491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (713)..(1441)

      <400> 22
 tatgaagata atttttaaaa cagttttttg gattaaagtc ccgtattttc caaaatagca     60

 catctcaatt ggttatattt cgagggttat caactagcta cgttgcaaga gctgagtcaa    120

 ctcaggaggc cagcggccac cataaggggc aatgcattta gagttcactt attaaatgct    180

 gacgttaaca gaacccacag agccgcattt cccttggttt cggaggacac gcgaaaaata    240

 acaacagcaa agggttctcg agcatctcct tcgcgccaga cggtgtgttg tactttgtca    300

 tcgtcgcagt aaggccggtg ctatcgccct cctagtttga ccaagcgaga ggactttctc    360

 cagatgggcc cctcccgaga gaatggtcgc cgtcccgctc tcctgttcgg gtcaccaccg    420

 gccgggcgcc actcgaacga gccccggcca gccgtcaccc taatcattcc cgaaggaggg    480

 gccatcagag ctacagctca tcagggtcaa tcagaagggg cgcccgcacg caaaggtcac    540

 ctgcaaaccg aagcggcgca cggataaggt ccgggacttg aagtctatct ccaaacattc    600

 aggctcctcc tccgactcct cctcgaactg gcgctcagag gcgccaccat tcggaaggag    660

 cccaggccac gcgcagctcg ccctcccgca ccgcgagggc agcagccgcc tc    atg     715
                                                              Met
                                                                1

 cga ctc gag aac gct aga ggg cgc cgc ttc cgg gag ccc gca agc ggc      763
 Arg Leu Glu Asn Ala Arg Gly Arg Arg Phe Arg Glu Pro Ala Ser Gly
               5                  10                  15

 ttc cgg gtg ctc gcg cgc cga cct gga cgc aga gaa gcc aga gac ttt      811
 Phe Arg Val Leu Ala Arg Arg Pro Gly Arg Arg Glu Ala Arg Asp Phe
          20                  25                  30

 cgc ttc cgg ctg ccg cag gcg ctt cgc tgg tgc aga cgc agt gct gag      859
 Arg Phe Arg Leu Pro Gln Ala Leu Arg Trp Cys Arg Arg Ser Ala Glu
      35                  40                  45

 cac aca gct acc gga caa aga gtg acg ccc gga gct gga gtt atg gcg      907
 His Thr Ala Thr Gly Gln Arg Val Thr Pro Gly Ala Gly Val Met Ala
  50                  55                  60                  65

 gct acg gag ccg atc ttg gcg gcc act ggg agt ccc gcg gcg gtg cca      955
 Ala Thr Glu Pro Ile Leu Ala Ala Thr Gly Ser Pro Ala Ala Val Pro
                  70                  75                  80

 ccg gag aaa ctg gaa gga gcc ggt tcg agc tca gcc cct gag cgt aac     1003
 Pro Glu Lys Leu Glu Gly Ala Gly Ser Ser Ser Ala Pro Glu Arg Asn
              85                  90                  95

 tgt gtg ggc tcc tcg ctg cca gag gcc tca ccg cct gcc cct gag cct     1051
 Cys Val Gly Ser Ser Leu Pro Glu Ala Ser Pro Pro Ala Pro Glu Pro
         100                 105                 110

 tcc agt ccc aac gcc gcg gtc cct gaa gcc atc cct acg ccc cga gct     1099
 Ser Ser Pro Asn Ala Ala Val Pro Glu Ala Ile Pro Thr Pro Arg Ala
     115                 120                 125

 gcg gcc tcc gcg gcc ctg gag ctg cct ctc ggg ccc gca ccc gtg agc     1147
 Ala Ala Ser Ala Ala Leu Glu Leu Pro Leu Gly Pro Ala Pro Val Ser
 130                 135                 140                 145

 gta gcg cct cag gcc gaa gct gaa gcg cgc tcc aca cca ggc ccc gcc     1195
 Val Ala Pro Gln Ala Glu Ala Glu Ala Arg Ser Thr Pro Gly Pro Ala
                 150                 155                 160

 ggc tct aga ctc ggt ccc gag acg ttc cgc cag cgt ttc cgg cag ttc     1243
 Gly Ser Arg Leu Gly Pro Glu Thr Phe Arg Gln Arg Phe Arg Gln Phe
             165                 170                 175

 cgc tac cag gat gcg gcg ggt ccc cgg gag gct ttc cgg cag ctg cgg     1291
 Arg Tyr Gln Asp Ala Ala Gly Pro Arg Glu Ala Phe Arg Gln Leu Arg
         180                 185                 190

 gag ctg tcc cgc cag tgg ctg cgg cct gac atc cgc acc aag gag cag     1339
 Glu Leu Ser Arg Gln Trp Leu Arg Pro Asp Ile Arg Thr Lys Glu Gln
     195                 200                 205

 atc gtg gag atg ctg gtg caa gag cag ctg ctc gcc atc ctg ccc gag     1387
 Ile Val Glu Met Leu Val Gln Glu Gln Leu Leu Ala Ile Leu Pro Glu
 210                 215                 220                 225

 gcg gct cgg gcc cgg cgg atc cgc cgc cgc acg gat gtg cgc atc act     1435
 Ala Ala Arg Ala Arg Arg Ile Arg Arg Arg Thr Asp Val Arg Ile Thr
                 230                 235                 240

 ggc tga gcggtggagc tgcgggcggc cagggccggg cgctctgtgc ggactggggc      1491
 Gly 






      <210> 23
      <211> 3278
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (36)..(3224)

      <400> 23
 tgcccattga aagcaaattt cggaacatct ggata   atg tcc acc ccg agc cga      53
                                          Met Ser Thr Pro Ser Arg
                                            1               5

 ttc aag aag gac aaa gag atc ata gcc gag tat gaa agt caa gtc aaa      101
 Phe Lys Lys Asp Lys Glu Ile Ile Ala Glu Tyr Glu Ser Gln Val Lys
              10                  15                  20

 gaa att cga gct caa ctg gta gaa caa caa aaa tgc ctg gag cag caa      149
 Glu Ile Arg Ala Gln Leu Val Glu Gln Gln Lys Cys Leu Glu Gln Gln
          25                  30                  35

 acg gag atg cga gtt cag ctt ctc cag gat ctg caa gat ttc ttc cga      197
 Thr Glu Met Arg Val Gln Leu Leu Gln Asp Leu Gln Asp Phe Phe Arg
      40                  45                  50

 aaa aaa gct gaa att gag acg gaa tat tcc cgg aat cta gag aag tta      245
 Lys Lys Ala Glu Ile Glu Thr Glu Tyr Ser Arg Asn Leu Glu Lys Leu
  55                  60                  65                  70

 gca gaa agg ttc atg gca aaa aca aga agc act aag gat cat caa caa      293
 Ala Glu Arg Phe Met Ala Lys Thr Arg Ser Thr Lys Asp His Gln Gln
                  75                  80                  85

 tac aag aaa gac cag aac ctg ttg tct cca gtg aac tgc tgg tat ttg      341
 Tyr Lys Lys Asp Gln Asn Leu Leu Ser Pro Val Asn Cys Trp Tyr Leu
              90                  95                 100

 ctc ctg aac caa gta agg aga gaa agc aaa gac cat gca acc ttg agt      389
 Leu Leu Asn Gln Val Arg Arg Glu Ser Lys Asp His Ala Thr Leu Ser
         105                 110                 115

 gac atc tat ctg aac aat gtg att atg cgg ttc atg cag ata agt gag      437
 Asp Ile Tyr Leu Asn Asn Val Ile Met Arg Phe Met Gln Ile Ser Glu
     120                 125                 130

 gat tct acc agg atg ttt aaa aag agc aaa gag att gca ttc caa ctt      485
 Asp Ser Thr Arg Met Phe Lys Lys Ser Lys Glu Ile Ala Phe Gln Leu
 135                 140                 145                 150

 cat gag gat tta atg aag gtt ctt aat gag ctt tat acg gtg atg aaa      533
 His Glu Asp Leu Met Lys Val Leu Asn Glu Leu Tyr Thr Val Met Lys
                 155                 160                 165

 aca tac cat atg tat cat gca gag agc atc agt gca gag agc aag ctg      581
 Thr Tyr His Met Tyr His Ala Glu Ser Ile Ser Ala Glu Ser Lys Leu
             170                 175                 180

 aaa gag gcc gaa aaa caa gag gaa aag caa att ggg aga tct ggt gat      629
 Lys Glu Ala Glu Lys Gln Glu Glu Lys Gln Ile Gly Arg Ser Gly Asp
         185                 190                 195

 cca gtc ttc cat att cga cta gag gag aga cat caa cgg cga agc tct      677
 Pro Val Phe His Ile Arg Leu Glu Glu Arg His Gln Arg Arg Ser Ser
     200                 205                 210

 gta aag aaa att gaa aaa aaa aaa aaa aaa aga caa gca aaa tat tca      725
 Val Lys Lys Ile Glu Lys Lys Lys Lys Lys Arg Gln Ala Lys Tyr Ser
 215                 220                 225                 230

 gaa aat aag cta aaa tca att aag gca cgg aac gaa tat ctc cta aca      773
 Glu Asn Lys Leu Lys Ser Ile Lys Ala Arg Asn Glu Tyr Leu Leu Thr
                 235                 240                 245

 ctt gaa gcc acc aat gcc tca gtt ttc aag tac tat att cat gat ctt      821
 Leu Glu Ala Thr Asn Ala Ser Val Phe Lys Tyr Tyr Ile His Asp Leu
             250                 255                 260

 tct gat tta att gat tgc tgt gat ctt ggc tac cat gca agt ctg aac      869
 Ser Asp Leu Ile Asp Cys Cys Asp Leu Gly Tyr His Ala Ser Leu Asn
         265                 270                 275

 aga gcc cta aga aca tat ctg tct gcg gag tac aac ctt gaa acc tcc      917
 Arg Ala Leu Arg Thr Tyr Leu Ser Ala Glu Tyr Asn Leu Glu Thr Ser
     280                 285                 290

 aga cat gag ggc tta gac att att gag aat gca gtt gat aat tta gag      965
 Arg His Glu Gly Leu Asp Ile Ile Glu Asn Ala Val Asp Asn Leu Glu
 295                 300                 305                 310

 ccc agg agc gat aag cag aga ttc atg gag atg tac cct gct gcg ttc     1013
 Pro Arg Ser Asp Lys Gln Arg Phe Met Glu Met Tyr Pro Ala Ala Phe
                 315                 320                 325

 tgt cca cca atg aag ttt gag ttt cag tct cac atg ggt gat gag gtg     1061
 Cys Pro Pro Met Lys Phe Glu Phe Gln Ser His Met Gly Asp Glu Val
             330                 335                 340

 tgc cag gtc agt gcc cag cag cca gtc cag gca gag ctc atg ctc agg     1109
 Cys Gln Val Ser Ala Gln Gln Pro Val Gln Ala Glu Leu Met Leu Arg
         345                 350                 355

 tac caa cag ttg cag tcc cgc ctt gcc acg ctc aaa atc gag aat gaa     1157
 Tyr Gln Gln Leu Gln Ser Arg Leu Ala Thr Leu Lys Ile Glu Asn Glu
     360                 365                 370

 gag gtt aag aaa acg act gaa gcc acc ttg cag acg ata caa gat atg     1205
 Glu Val Lys Lys Thr Thr Glu Ala Thr Leu Gln Thr Ile Gln Asp Met
 375                 380                 385                 390

 gtc acc atc gag gac tat gat gtt tct gaa tgc ttc cag cac agt cgt     1253
 Val Thr Ile Glu Asp Tyr Asp Val Ser Glu Cys Phe Gln His Ser Arg
                 395                 400                 405

 tcc aca gaa tct gtg aag tcc act gtc tct gaa acc tac ctg agt aaa     1301
 Ser Thr Glu Ser Val Lys Ser Thr Val Ser Glu Thr Tyr Leu Ser Lys
             410                 415                 420

 ccc agc atc gcc aag aga aga gcc aac cag cag gaa act gaa cag ttc     1349
 Pro Ser Ile Ala Lys Arg Arg Ala Asn Gln Gln Glu Thr Glu Gln Phe
         425                 430                 435

 tac ttc atg aaa ctc aga gaa tat ttg gaa ggc agt aat ctc atc aca     1397
 Tyr Phe Met Lys Leu Arg Glu Tyr Leu Glu Gly Ser Asn Leu Ile Thr
     440                 445                 450

 aaa ctt caa gcc aaa cat gac ttg ctg cag agg acc ctg gga gaa ggt     1445
 Lys Leu Gln Ala Lys His Asp Leu Leu Gln Arg Thr Leu Gly Glu Gly
 455                 460                 465                 470

 cat aga gct gaa tat atg act aca agc cga gga cga aga aac tcg cac     1493
 His Arg Ala Glu Tyr Met Thr Thr Ser Arg Gly Arg Arg Asn Ser His
                 475                 480                 485

 aca aga cat cag gac tca gga cag gtt att ccc ctc att gtg gaa agc     1541
 Thr Arg His Gln Asp Ser Gly Gln Val Ile Pro Leu Ile Val Glu Ser
             490                 495                 500

 tgt att cgg ttc atc aat ctc tat ggt ctt cag cat cag ggg att ttc     1589
 Cys Ile Arg Phe Ile Asn Leu Tyr Gly Leu Gln His Gln Gly Ile Phe
         505                 510                 515

 aga gtg tct ggt tcc cag gtg gaa gtc aat gat att aaa aat tca ttt     1637
 Arg Val Ser Gly Ser Gln Val Glu Val Asn Asp Ile Lys Asn Ser Phe
     520                 525                 530

 gag aga ggt gaa aat cct ttg gct gat gac cag agt aac cat gat att     1685
 Glu Arg Gly Glu Asn Pro Leu Ala Asp Asp Gln Ser Asn His Asp Ile
 535                 540                 545                 550

 aac tca gtt gct ggc gtt ctg aag ctc tat ttc cgt ggg ctg gaa aac     1733
 Asn Ser Val Ala Gly Val Leu Lys Leu Tyr Phe Arg Gly Leu Glu Asn
                 555                 560                 565

 ccc ctc ttt cct aag gaa aga ttt aac gat ctg att tct tgt atc aga     1781
 Pro Leu Phe Pro Lys Glu Arg Phe Asn Asp Leu Ile Ser Cys Ile Arg
             570                 575                 580

 ata gat aat ctc tat gag agg gcg ctt cac atc cgc aaa ctc ctc ctg     1829
 Ile Asp Asn Leu Tyr Glu Arg Ala Leu His Ile Arg Lys Leu Leu Leu
         585                 590                 595

 act ttg ccc agg tcg gtc ctt ata gtg atg agg tac ctc ttt gcc ttc     1877
 Thr Leu Pro Arg Ser Val Leu Ile Val Met Arg Tyr Leu Phe Ala Phe
     600                 605                 610

 ctc aat cat cta tca cag tac agc gat gag aat atg atg gac cct tat     1925
 Leu Asn His Leu Ser Gln Tyr Ser Asp Glu Asn Met Met Asp Pro Tyr
 615                 620                 625                 630

 aac ctg gcc att tgc ttt ggc cca aca ttg atg cct gtc cca gaa ata     1973
 Asn Leu Ala Ile Cys Phe Gly Pro Thr Leu Met Pro Val Pro Glu Ile
                 635                 640                 645

 cag gat caa gtg tct tgc cag gca cat gtg aat gaa att atc aaa acc     2021
 Gln Asp Gln Val Ser Cys Gln Ala His Val Asn Glu Ile Ile Lys Thr
             650                 655                 660

 atc atc atc cac cat gag act att ttc cca gat gct aaa gag ctg gat     2069
 Ile Ile Ile His His Glu Thr Ile Phe Pro Asp Ala Lys Glu Leu Asp
         665                 670                 675

 ggc cct gtt tat gag aaa tgt atg gct gga gat gac tat tgc gac agc     2117
 Gly Pro Val Tyr Glu Lys Cys Met Ala Gly Asp Asp Tyr Cys Asp Ser
     680                 685                 690

 cca tac agt gag cac ggt aca ttg gag gaa gtg gac caa gat gct ggt     2165
 Pro Tyr Ser Glu His Gly Thr Leu Glu Glu Val Asp Gln Asp Ala Gly
 695                 700                 705                 710

 aca gag ccc cac aca agt gaa gat gaa tgt gag cca ata gaa gca ata     2213
 Thr Glu Pro His Thr Ser Glu Asp Glu Cys Glu Pro Ile Glu Ala Ile
                 715                 720                 725

 gcc aag ttt gac tat gtt ggg cgg tcc gcc aga gaa cta tcc ttc aag     2261
 Ala Lys Phe Asp Tyr Val Gly Arg Ser Ala Arg Glu Leu Ser Phe Lys
             730                 735                 740

 aag ggt gcc tcc ctg ctg ctg tat cac cgt gca tct gag gac tgg tgg     2309
 Lys Gly Ala Ser Leu Leu Leu Tyr His Arg Ala Ser Glu Asp Trp Trp
         745                 750                 755

 gaa ggc agg cac aac ggg att gac ggg ctg gtg cct cac cag tat ata     2357
 Glu Gly Arg His Asn Gly Ile Asp Gly Leu Val Pro His Gln Tyr Ile
     760                 765                 770

 gtg gtg cag gat atg gat gat acg ttt tca gac act ctg agc caa aaa     2405
 Val Val Gln Asp Met Asp Asp Thr Phe Ser Asp Thr Leu Ser Gln Lys
 775                 780                 785                 790

 gcc gac agt gag gcc agc agt ggg cca gtc acg gaa gac aag tcc tca     2453
 Ala Asp Ser Glu Ala Ser Ser Gly Pro Val Thr Glu Asp Lys Ser Ser
                 795                 800                 805

 tcc aag gac atg aac tcc ccg aca gac cgt cat cct gac ggc tat tta     2501
 Ser Lys Asp Met Asn Ser Pro Thr Asp Arg His Pro Asp Gly Tyr Leu
             810                 815                 820

 gcc agg caa cga aaa aga gga gag cca ccc cct cca gta agg cgt cct     2549
 Ala Arg Gln Arg Lys Arg Gly Glu Pro Pro Pro Pro Val Arg Arg Pro
         825                 830                 835

 ggc agg acc agt gat ggc cat tgc ccg ctc cac cct cca cat gcc ctt     2597
 Gly Arg Thr Ser Asp Gly His Cys Pro Leu His Pro Pro His Ala Leu
     840                 845                 850

 tct aac tcc tca gtt gac cta ggg tcc cca agc ctt gcc agt cac ccc     2645
 Ser Asn Ser Ser Val Asp Leu Gly Ser Pro Ser Leu Ala Ser His Pro
 855                 860                 865                 870

 cgg ggc ctg ctg cag aac cgt ggc ctc aac aat gac agt cct gag cgg     2693
 Arg Gly Leu Leu Gln Asn Arg Gly Leu Asn Asn Asp Ser Pro Glu Arg
                 875                 880                 885

 agg cgc agg cct ggc cat ggc agc ctg acc aac atc agc cgg cac gac     2741
 Arg Arg Arg Pro Gly His Gly Ser Leu Thr Asn Ile Ser Arg His Asp
             890                 895                 900

 tcc ctc aag aag atc gac agc cct ccc att aga agg tcc acg tca tca     2789
 Ser Leu Lys Lys Ile Asp Ser Pro Pro Ile Arg Arg Ser Thr Ser Ser
         905                 910                 915

 ggg caa tac acg ggc ttc aat gac cac aag cca ctg gac cca gag aca     2837
 Gly Gln Tyr Thr Gly Phe Asn Asp His Lys Pro Leu Asp Pro Glu Thr
     920                 925                 930

 att gct cag gat att gaa gaa acg atg aac aca gct ttg aat gaa ctc     2885
 Ile Ala Gln Asp Ile Glu Glu Thr Met Asn Thr Ala Leu Asn Glu Leu
 935                 940                 945                 950

 cga gaa ctg gag aga cag agc aca gca aag cat gcc cct gat gtg gtg     2933
 Arg Glu Leu Glu Arg Gln Ser Thr Ala Lys His Ala Pro Asp Val Val
                 955                 960                 965

 ctg gat acc ctg gag caa gtg aaa aac tct ccc acc cct gcc act tcc     2981
 Leu Asp Thr Leu Glu Gln Val Lys Asn Ser Pro Thr Pro Ala Thr Ser
             970                 975                 980

 acg gaa tct ctc agc cct ttg cac aac gtt gcc ctc agg agc tcc gag     3029
 Thr Glu Ser Leu Ser Pro Leu His Asn Val Ala Leu Arg Ser Ser Glu
         985                 990                 995

 cct cag att cga cgt agc acg agc tcc tcc agt gac aca atg agt act     3077
 Pro Gln Ile Arg Arg Ser Thr Ser Ser Ser Ser Asp Thr Met Ser Thr
    1000                1005                1010

 ttc aag cct atg gtg gca ccc aga atg ggc gtg cag ctg aag cct cca     3125
 Phe Lys Pro Met Val Ala Pro Arg Met Gly Val Gln Leu Lys Pro Pro
1015                1020                1025                1030

 gcc ctt agg cca aaa cct gct gtt ctt cca aaa aca aat cct acc ata     3173
 Ala Leu Arg Pro Lys Pro Ala Val Leu Pro Lys Thr Asn Pro Thr Ile
                1035                1040                1045

 gga cct gcc cca cct ccc cag ggt cca aca gac aag tca tgc aca atg     3221
 Gly Pro Ala Pro Pro Pro Gln Gly Pro Thr Asp Lys Ser Cys Thr Met
            1050                1055                1060

 taa aaac cagccaagca aggccataaa gggaggtgac ttaaaaaaga aaatggatta     3278
 






      <210> 24
      <211> 1177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (95)..(1123)

      <400> 24
 tcacacaagc agaagcaaat gtattcttac agaagcttct gcatcagttc tctgtttcgt     60

 cttttacccg ttttacctgg gtacaccgaa ccac    atg gga ccc ctt aat cag     112
                                          Met Gly Pro Leu Asn Gln
                                            1               5

 gtg tcc ttc cat gtt ttc cat ttc ctg gtc cgt gct gtc gtc ctc tac      160
 Val Ser Phe His Val Phe His Phe Leu Val Arg Ala Val Val Leu Tyr
              10                  15                  20

 att ttg gat ttc atg ata gag gca aga cgt tgt aga atg aat gaa gac      208
 Ile Leu Asp Phe Met Ile Glu Ala Arg Arg Cys Arg Met Asn Glu Asp
          25                  30                  35

 act ggc act gat tat ata aca cct tgg cag cta tct caa gtc gtt gat      256
 Thr Gly Thr Asp Tyr Ile Thr Pro Trp Gln Leu Ser Gln Val Val Asp
      40                  45                  50

 gga gga ggt att gga att ata gaa gaa agc aaa cac aca aat ttg act      304
 Gly Gly Gly Ile Gly Ile Ile Glu Glu Ser Lys His Thr Asn Leu Thr
  55                  60                  65                  70

 aaa ggc gat ttt gtg act tct ttc tat tgg ccc tgg caa acc aag gtt      352
 Lys Gly Asp Phe Val Thr Ser Phe Tyr Trp Pro Trp Gln Thr Lys Val
                  75                  80                  85

 att ctg gat gga aat agc ctt gaa aag gct agc gat atc agt atg aca      400
 Ile Leu Asp Gly Asn Ser Leu Glu Lys Ala Ser Asp Ile Ser Met Thr
              90                  95                 100

 ctc tct cga gat gct ggg cag cgg caa caa gct gta gct cct ggt cag      448
 Leu Ser Arg Asp Ala Gly Gln Arg Gln Gln Ala Val Ala Pro Gly Gln
         105                 110                 115

 cca ccg tat gtg gct gaa caa ctc cgt gaa tca tgc cca gct gga gtg      496
 Pro Pro Tyr Val Ala Glu Gln Leu Arg Glu Ser Cys Pro Ala Gly Val
     120                 125                 130

 gat gtt tat ttt gac aat gac cat aag ggt aaa caa ctg gta ctc tac      544
 Asp Val Tyr Phe Asp Asn Asp His Lys Gly Lys Gln Leu Val Leu Tyr
 135                 140                 145                 150

 ggt gta ctg tgt tgc cag atg att ttg ccc agc cat aag tgt tct gag      592
 Gly Val Leu Cys Cys Gln Met Ile Leu Pro Ser His Lys Cys Ser Glu
                 155                 160                 165

 cat gtt tta ggt tgt tcc aga gtg gtg gga att tgt gga aca cat gag      640
 His Val Leu Gly Cys Ser Arg Val Val Gly Ile Cys Gly Thr His Glu
             170                 175                 180

 aaa tgc atc ctc ttg acc tca gaa ctg ggc ttt gat gct gca att aat      688
 Lys Cys Ile Leu Leu Thr Ser Glu Leu Gly Phe Asp Ala Ala Ile Asn
         185                 190                 195

 tat aaa aaa gac aat gtg gca gaa cag ctc cgt gaa tca tgc cca gct      736
 Tyr Lys Lys Asp Asn Val Ala Glu Gln Leu Arg Glu Ser Cys Pro Ala
     200                 205                 210

 gga gtg gat gtt tat ttt gac aat gtt ggt ggt aac atc agt gat aca      784
 Gly Val Asp Val Tyr Phe Asp Asn Val Gly Gly Asn Ile Ser Asp Thr
 215                 220                 225                 230

 gtg ata agt cag atg aat gag aac agc cac atc atc ctg tgt ggt caa      832
 Val Ile Ser Gln Met Asn Glu Asn Ser His Ile Ile Leu Cys Gly Gln
                 235                 240                 245

 att tct cag tac aac aaa gat gtg cct tat cct ccc ccg cta tcc cct      880
 Ile Ser Gln Tyr Asn Lys Asp Val Pro Tyr Pro Pro Pro Leu Ser Pro
             250                 255                 260

 gct ata gag gca atc cag aaa gaa aga aac atc aca agg gaa aga ttt      928
 Ala Ile Glu Ala Ile Gln Lys Glu Arg Asn Ile Thr Arg Glu Arg Phe
         265                 270                 275

 ctg gta tta aat tat aaa gac aaa ttt gag cct ggc att cta cag ctg      976
 Leu Val Leu Asn Tyr Lys Asp Lys Phe Glu Pro Gly Ile Leu Gln Leu
     280                 285                 290

 agt cag tgg ttt aaa gaa gga aag cta aag att aaa gag acg gta ata     1024
 Ser Gln Trp Phe Lys Glu Gly Lys Leu Lys Ile Lys Glu Thr Val Ile
 295                 300                 305                 310

 aat ggg ttg gaa aac atg gga gct gca ttc cag tcc atg atg aca gga     1072
 Asn Gly Leu Glu Asn Met Gly Ala Ala Phe Gln Ser Met Met Thr Gly
                 315                 320                 325

 ggt aac att gga aag cag ata gtt tgc att tca gaa gaa atc tct ttg     1120
 Gly Asn Ile Gly Lys Gln Ile Val Cys Ile Ser Glu Glu Ile Ser Leu
             330                 335                 340

 taa ttgc tgtaaatgtc atcaaggcaa tcatagattt cttttccatt ttgcatattt     1177
 






      <210> 25
      <211> 2426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (687)..(2096)

      <400> 25
 tactatctat catggaataa catccaagaa agacaccttg catattcttt cagtttctgt     60

 tttgttctcc cacatattct cttcaatgct caggaagcct gccctgtgct tgagagttca    120

 gggccggaca caggctcaca ggtctccaca ttgggtccct gtctctggtg cccacagtga    180

 gctccttctt ggctgagcag gcatggagac tgtaggtttc cagatttcct cttcctaggc    240

 ccacagccag tgcctttgga gtactgaggc gcgcacagag tccttagccc ggcgcagggc    300

 gcgcagccca ggctgagatc cgctgcttct gtggaagtga gcatggttgg gcagcgggtg    360

 ctgcttctag tggccttcct tctttctggg gtcctgctct cagaggctgc caaaatcctg    420

 acaatatcta cactgggtga gtgcttggcc ggagaattcc cagacaggcg cgtcccggat    480

 ccccgcactg ccagggctcc agcgaacggc gattgatcag agttatccag gcgattttcc    540

 aggctgggct tgcggacctg gctggaggag ggagaagcca atctagccgt ggggcagaga    600

 ggggcctcta ttgctgaggt ggaagccatt acctactgtt ggaccgggtg tctcagattc    660

 ttcaagagca tggtcataat gtgact atg ctt cat cag agt gga aag ttt ttg     713
                              Met Leu His Gln Ser Gly Lys Phe Leu
                                1               5

 atc cca gat att aaa gag gag gaa aaa tca tac caa gtt atc agg tgg      761
 Ile Pro Asp Ile Lys Glu Glu Glu Lys Ser Tyr Gln Val Ile Arg Trp
  10                  15                  20                  25

 ttt tca cct gaa gat cat caa aaa aga att aag aag cat ttt gat agc      809
 Phe Ser Pro Glu Asp His Gln Lys Arg Ile Lys Lys His Phe Asp Ser
                  30                  35                  40

 tac ata gaa aca gca ttg gat ggc aga aaa gaa tct gaa gcc ctt gta      857
 Tyr Ile Glu Thr Ala Leu Asp Gly Arg Lys Glu Ser Glu Ala Leu Val
              45                  50                  55

 aag cta atg gaa ata ttt ggg act caa tgt agt tat ttg cta agc aga      905
 Lys Leu Met Glu Ile Phe Gly Thr Gln Cys Ser Tyr Leu Leu Ser Arg
          60                  65                  70

 aag gat ata atg gat tcc tta aag aat gag aac tat gat ctg gta ttt      953
 Lys Asp Ile Met Asp Ser Leu Lys Asn Glu Asn Tyr Asp Leu Val Phe
      75                  80                  85

 gtt gaa gca ttt gat ttc tgt tct ttc ctg att gct gag aag ctt gtg     1001
 Val Glu Ala Phe Asp Phe Cys Ser Phe Leu Ile Ala Glu Lys Leu Val
  90                  95                 100                 105

 aaa cca ttt gtg gcc att ctt ccc acc aca ttc ggc tct ttg gat ttt     1049
 Lys Pro Phe Val Ala Ile Leu Pro Thr Thr Phe Gly Ser Leu Asp Phe
                 110                 115                 120

 ggg cta cca agc ccc ttg tct tat gtt cca gta ttc cct tcc ttg ctg     1097
 Gly Leu Pro Ser Pro Leu Ser Tyr Val Pro Val Phe Pro Ser Leu Leu
             125                 130                 135

 act gat cac atg gac ttc tgg ggc cga gtg aag aat ttt ctg atg ttc     1145
 Thr Asp His Met Asp Phe Trp Gly Arg Val Lys Asn Phe Leu Met Phe
         140                 145                 150

 ttt agt ttc tcc agg agc caa tgg gac atg cag tct aca ttt gac aac     1193
 Phe Ser Phe Ser Arg Ser Gln Trp Asp Met Gln Ser Thr Phe Asp Asn
     155                 160                 165

 acc atc aag gag cat ttc cca gaa ggc tct agg cca gtt ttg tct cat     1241
 Thr Ile Lys Glu His Phe Pro Glu Gly Ser Arg Pro Val Leu Ser His
 170                 175                 180                 185

 ctt cta ctg aaa gca gag ttg tgg ttt gtt aac tct gat ttt gcc ttt     1289
 Leu Leu Leu Lys Ala Glu Leu Trp Phe Val Asn Ser Asp Phe Ala Phe
                 190                 195                 200

 gat ttt gcc cgg ccc ctg ctt ccc aac act gtt tat att gga ggc ttg     1337
 Asp Phe Ala Arg Pro Leu Leu Pro Asn Thr Val Tyr Ile Gly Gly Leu
             205                 210                 215

 atg gaa aaa cct att aaa cca gta cca caa gac ttg gac aac ttc att     1385
 Met Glu Lys Pro Ile Lys Pro Val Pro Gln Asp Leu Asp Asn Phe Ile
         220                 225                 230

 gcc aac ttt ggg gat gca ggg ttt gtc ctt gtg gcc ttt ggc tcc atg     1433
 Ala Asn Phe Gly Asp Ala Gly Phe Val Leu Val Ala Phe Gly Ser Met
     235                 240                 245

 ttg aac acc cat cag tcc cag gaa gtc ctc aag aag atg cac aat gcc     1481
 Leu Asn Thr His Gln Ser Gln Glu Val Leu Lys Lys Met His Asn Ala
 250                 255                 260                 265

 ttt gcc cac ctc cct caa gga gtg ata tgg aca tgt cag agt tct cat     1529
 Phe Ala His Leu Pro Gln Gly Val Ile Trp Thr Cys Gln Ser Ser His
                 270                 275                 280

 tgg ccc aga gat gtt cat ttg gcc aca aat gtg aaa att gtg gac tgg     1577
 Trp Pro Arg Asp Val His Leu Ala Thr Asn Val Lys Ile Val Asp Trp
             285                 290                 295

 ctt cct cag agt gac ctc ctg gct cac ccc agc atc cgt ctt ttt gtc     1625
 Leu Pro Gln Ser Asp Leu Leu Ala His Pro Ser Ile Arg Leu Phe Val
         300                 305                 310

 act cat ggt ggg cag aac agc gta atg gag gcc atc cgt cat ggt gtg     1673
 Thr His Gly Gly Gln Asn Ser Val Met Glu Ala Ile Arg His Gly Val
     315                 320                 325

 ccc atg gtg gga tta cca gtc aat gga gac cag cat gga aac atg gtc     1721
 Pro Met Val Gly Leu Pro Val Asn Gly Asp Gln His Gly Asn Met Val
 330                 335                 340                 345

 cga gta gta gcc aaa aat tat ggt gtc tct atc cgg ttg aat cag gtc     1769
 Arg Val Val Ala Lys Asn Tyr Gly Val Ser Ile Arg Leu Asn Gln Val
                 350                 355                 360

 aca gcc gac aca ctg aca ctt aca atg aaa caa gtc ata gaa gac aag     1817
 Thr Ala Asp Thr Leu Thr Leu Thr Met Lys Gln Val Ile Glu Asp Lys
             365                 370                 375

 agg tac aag tcg gca gtg gtg gca gcc agt gtc atc ctg cac tct cag     1865
 Arg Tyr Lys Ser Ala Val Val Ala Ala Ser Val Ile Leu His Ser Gln
         380                 385                 390

 ccc ctg agc ccc gca cag cgg ctg gtg ggc tgg atc gac cac atc ctc     1913
 Pro Leu Ser Pro Ala Gln Arg Leu Val Gly Trp Ile Asp His Ile Leu
     395                 400                 405

 cag act ggg gga gcg acg cac ctc aag ccc tat gcc ttc cag cag cct     1961
 Gln Thr Gly Gly Ala Thr His Leu Lys Pro Tyr Ala Phe Gln Gln Pro
 410                 415                 420                 425

 tgg cat gag cag tac ctc att gat gtc ttt gtg ttt ctg ctg ggg ctc     2009
 Trp His Glu Gln Tyr Leu Ile Asp Val Phe Val Phe Leu Leu Gly Leu
                 430                 435                 440

 act ctg ggc act atg tgg ctt tgt ggg aag ctg ctg ggt gtg gtg gcc     2057
 Thr Leu Gly Thr Met Trp Leu Cys Gly Lys Leu Leu Gly Val Val Ala
             445                 450                 455

 agg tgg ctg cgt ggg gcc agg aag gtg aag aag aca tga ggctaggtgt      2106
 Arg Trp Leu Arg Gly Ala Arg Lys Val Lys Lys Thr 
         460                 465

 agccttgggt gaggggaggg catccctggt cctttgaagg ttctccccac cccagcacac   2166

 gccacccctc tgttctctct tcagctccac ctgccactga tcttgcaact tgcttctttc   2226

 tattctctgc ctctgtttag aaatcttcac gcaccactga ggcttcttga cttgcccctt   2286

 gtgacttgaa accccagctc agatacaaat tttcacctgc cagccctgcc tcctcctttc   2346

 tcccttttcc tagacacagg actctgacaa cttcatcctc cttgtttaga tgacttccca   2406

 gtttccagtc cccatttctc                                               2426




      <210> 26
      <211> 2628
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(1651)

      <400> 26
 gatccccacc acaccaccag cccggccgca cggggcactg agccgggtgc tgagcaccgg     60

 aggccccgcc gaggccggga ctcaggacct gcagagaaac gcctcctgat tttgtcttac    120

 a    atg gaa ctt aaa aag tcg cct gac ggt gga tgg ggc tgg gtg att     166
      Met Glu Leu Lys Lys Ser Pro Asp Gly Gly Trp Gly Trp Val Ile
        1               5                  10                  15

 gtg ttt gtc tcc ttc ctt act cag ttt ttg tgt tac gga tcc cca cta      214
 Val Phe Val Ser Phe Leu Thr Gln Phe Leu Cys Tyr Gly Ser Pro Leu
                  20                  25                  30

 gct gtt gga gtc ctg tac ata gaa tgg ctg gat gcc ttt ggt gaa gga      262
 Ala Val Gly Val Leu Tyr Ile Glu Trp Leu Asp Ala Phe Gly Glu Gly
              35                  40                  45

 aaa gga aaa aca gcc tgg gtt gga tcc ctg gca agt gga gtt ggc ttg      310
 Lys Gly Lys Thr Ala Trp Val Gly Ser Leu Ala Ser Gly Val Gly Leu
          50                  55                  60

 ctt gca agt cct gtc tgc agt ctc tgt gtc tca tct ttt gga gca aga      358
 Leu Ala Ser Pro Val Cys Ser Leu Cys Val Ser Ser Phe Gly Ala Arg
      65                  70                  75

 cct gtc aca atc ttc agt ggc ttc atg gtg gct gga ggc ctg atg ttg      406
 Pro Val Thr Ile Phe Ser Gly Phe Met Val Ala Gly Gly Leu Met Leu
  80                  85                  90                  95

 agc agt ttt gct ccc aat atc tac ttt ctg ttt ttt tcc tat ggc att      454
 Ser Ser Phe Ala Pro Asn Ile Tyr Phe Leu Phe Phe Ser Tyr Gly Ile
                 100                 105                 110

 gtt gta ggt ctt gga tgt ggt tta tta tac act gca aca gtg acc att      502
 Val Val Gly Leu Gly Cys Gly Leu Leu Tyr Thr Ala Thr Val Thr Ile
             115                 120                 125

 acg tgc cag tat ttt gac gat cgc cga ggc cta gcg ctt ggc ctg att      550
 Thr Cys Gln Tyr Phe Asp Asp Arg Arg Gly Leu Ala Leu Gly Leu Ile
         130                 135                 140

 tca aca ggt tca agc gtt ggc ctt ttc ata tat gct gct ctg cag agg      598
 Ser Thr Gly Ser Ser Val Gly Leu Phe Ile Tyr Ala Ala Leu Gln Arg
     145                 150                 155

 atg ctg gtt gag ttc tat gga ctg gat gga tgc ttg ctg att gtg ggt      646
 Met Leu Val Glu Phe Tyr Gly Leu Asp Gly Cys Leu Leu Ile Val Gly
 160                 165                 170                 175

 gct tta gct tta aat ata tta gcc tgt ggc agt ctg atg aga ccc ctc      694
 Ala Leu Ala Leu Asn Ile Leu Ala Cys Gly Ser Leu Met Arg Pro Leu
                 180                 185                 190

 caa tct tct gat tgt cct ttg cct aaa aaa ata gct cca gaa gat cta      742
 Gln Ser Ser Asp Cys Pro Leu Pro Lys Lys Ile Ala Pro Glu Asp Leu
             195                 200                 205

 cca gat aaa tac tcc att tac aat gaa aaa gga aag aat ctg gaa gaa      790
 Pro Asp Lys Tyr Ser Ile Tyr Asn Glu Lys Gly Lys Asn Leu Glu Glu
         210                 215                 220

 aac ata aac att ctt gac aag agc tac agt agt gag gaa aaa tgc agg      838
 Asn Ile Asn Ile Leu Asp Lys Ser Tyr Ser Ser Glu Glu Lys Cys Arg
     225                 230                 235

 atc acg tta gcc aat ggt gac tgg aaa caa gac agc cta ctt cat aaa      886
 Ile Thr Leu Ala Asn Gly Asp Trp Lys Gln Asp Ser Leu Leu His Lys
 240                 245                 250                 255

 aac ccc aca gtg aca cac aca aaa gag cct gaa acg tac aaa aag aaa      934
 Asn Pro Thr Val Thr His Thr Lys Glu Pro Glu Thr Tyr Lys Lys Lys
                 260                 265                 270

 gtt gca gaa cag aca tat ttt tgc aaa cag ctt gcc aag agg aag tgg      982
 Val Ala Glu Gln Thr Tyr Phe Cys Lys Gln Leu Ala Lys Arg Lys Trp
             275                 280                 285

 cag tta tat aaa aac tac tgt ggt gaa act gtg gct ctt ttt aaa aac     1030
 Gln Leu Tyr Lys Asn Tyr Cys Gly Glu Thr Val Ala Leu Phe Lys Asn
         290                 295                 300

 aaa gta ttt tca gcc ctt ttc att gct atc tta ctc ttt gac atc gga     1078
 Lys Val Phe Ser Ala Leu Phe Ile Ala Ile Leu Leu Phe Asp Ile Gly
     305                 310                 315

 ggg ttt cca cct tca tta ctt atg gaa gat gta gca aga agt tca aac     1126
 Gly Phe Pro Pro Ser Leu Leu Met Glu Asp Val Ala Arg Ser Ser Asn
 320                 325                 330                 335

 gtg aaa gaa gaa gag ttt att atg cca ctt att tcc att ata ggc att     1174
 Val Lys Glu Glu Glu Phe Ile Met Pro Leu Ile Ser Ile Ile Gly Ile
                 340                 345                 350

 atg aca gca gtt ggt aaa ctg ctt tta ggg ata ctg gct gac ttc aag     1222
 Met Thr Ala Val Gly Lys Leu Leu Leu Gly Ile Leu Ala Asp Phe Lys
             355                 360                 365

 tgg att aat acc ttg tat ctt tat gtt gct acc tta atc atc atg ggc     1270
 Trp Ile Asn Thr Leu Tyr Leu Tyr Val Ala Thr Leu Ile Ile Met Gly
         370                 375                 380

 cta gcc ttg tgt gca att cca ttt gcc aaa agc tat gtc aca ttg gcg     1318
 Leu Ala Leu Cys Ala Ile Pro Phe Ala Lys Ser Tyr Val Thr Leu Ala
     385                 390                 395

 ttg ctt tct ggg atc cta ggg ttt ctt act ggt aat tgg tcc atc ttt     1366
 Leu Leu Ser Gly Ile Leu Gly Phe Leu Thr Gly Asn Trp Ser Ile Phe
 400                 405                 410                 415

 cca tat gtg acc acg aag act gtg gga att gaa aaa tta gcc cat gcc     1414
 Pro Tyr Val Thr Thr Lys Thr Val Gly Ile Glu Lys Leu Ala His Ala
                 420                 425                 430

 tat ggg ata tta atg ttc ttt gct gga ctt gga aat agc cta gga cca     1462
 Tyr Gly Ile Leu Met Phe Phe Ala Gly Leu Gly Asn Ser Leu Gly Pro
             435                 440                 445

 ccc atc gtt ggt tgg ttt tat gac tgg acc cag acc tat gat att gca     1510
 Pro Ile Val Gly Trp Phe Tyr Asp Trp Thr Gln Thr Tyr Asp Ile Ala
         450                 455                 460

 ttt tat ttt agt ggc ttc tgc gtc ctg ctg gga ggt ttt att ctg ctg     1558
 Phe Tyr Phe Ser Gly Phe Cys Val Leu Leu Gly Gly Phe Ile Leu Leu
     465                 470                 475

 ctg gca gcc ttg ccc tct tgg gat aca tgc aac aag caa ctc ccc aag     1606
 Leu Ala Ala Leu Pro Ser Trp Asp Thr Cys Asn Lys Gln Leu Pro Lys
 480                 485                 490                 495

 cca gct cca aca act ttc ttg tac aaa gtt gcc tct aat gtt tag aag     1654
 Pro Ala Pro Thr Thr Phe Leu Tyr Lys Val Ala Ser Asn Val 
                 500                 505

 aatattggaa gacactattt ttgctatttt ataccatata gcaacgatat tttaacagat   1714

 tctcaagcaa attttctaga gtcaagacta ttttctcata gcaaaatttc acaatgactg   1774

 actctgaatg aattattttt ttttatatat cctatttttt atgtagtgta tgcgtagcct   1834

 ctatctcgta tctttttcta tttctcctcc ccacaccatc aatgggacta ttctgttttg   1894

 ctgttattca ctagttctta acattgtaaa aagtttgacc agcctcagaa ggctttctct   1954

 gtgtaaagaa gtataatttc tctgccgact ccatttaatc cactgcaagg cacctagaga   2014

 gactgctcct attttaaaag tgatgcaagc atcatgataa gatatgtgtg aagcccacta   2074

 ggaaataaat cattctcttc tctatgtttg acttgctagt aaacagaaga cttcaagcca   2134

 gccaggaaat taaagtggcg actaaaacag ccttaagaat tgcagtggag caaattggtc   2194

 attttttaaa aaaatatatt ttaacctaca gtcaccagtt ttcattattc tatttacctc   2254

 actgaagtac tcgcatgttg tttggtaccc actgagcaac tgtttcagtt cctaaggtat   2314

 ttgctgagat gtgggtgaac tccaaatgga gaagtagtca ctgtagactt tcttcatggt   2374

 tgaccactcc aaccttgctc acttttgctt cttggccatc cactcagctg atgtttcctg   2434

 ggaagtgcta attttacctg tttccaaatt ggaaacacat ttctcaatca ttccgttctg   2494

 gcaaatggga aacatccatt tgctttgggc acagtgggga tgggctgcaa gttcttgcat   2554

 atcctcccag tgaagcattt atttgctact atcagatttt accactatca aatataattc   2614

 aagggcagaa ttaa                                                     2628




      <210> 27
      <211> 2516
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1063)..(1434)

      <400> 27
 ggccgaccaa ccagaataat cggttctcca gaaagagcga accgccccgc ctagggaagg     60

 tcacagaggc cccgttaccg cccagcatgt gtaaggccgc cgcctggggc acaagcagac    120

 ctttccccgc gtggagcaaa cccgcaaatc tttggggaag gaaggtgccc atccggtcgt    180

 ccccccaagc accaggtgaa agccccggcg ccttggggcc aagggccctc gaagcttgga    240

 aaggcttcgg ggcccaacag gctatagcca agccggcttc agaatccggg cccccgaccg    300

 cccaaggaaa aggtgcctct cacacaccgg aggctccagc atggggcggc aatttcgggt    360

 ccagggcacg gcgtgtcaga ggccacgggc gggaaactag aaggaacagg tgtggctgga    420

 agcctggggg cgaggggcat cggagaggcc cgggaggcta aaaggagaac gcgggcgcag    480

 acaccgaggg gcgccgcagg cgacgtgggc tttttggagg aacagggaca ggtcctgaga    540

 cccctttggg ccgaccacac ccccctcctg cgtgcggggg cagacgtccc cggtggggta    600

 gactggcagc ctaatccacg gcgcgggagg gcaggtggga gactggaggc gccctcgcgc    660

 ccctcagcta tccgggagcc tcgcgccggc gacctcgacc ctgtcgaacc cggcggacac    720

 gtcagaaaga agctgagcgc ctcgcagcgg ccaggacagc gggccagccc gcgcgctccc    780

 gcagcgcacg gccagacgcg acgcccctca gcacggaacc cagcctcgcg gactaccccg    840

 aagctcagag ccacatcccg cgcagaggac cgcggcgacc ggaaaagcaa ggcagaggcg    900

 gaaaaccacc gcgagcgctg gggcgagaga gggcaggcgg aggctcgcgg ggaccaccag    960

 catccccgga ccctctcagc cgtccctgtt cacaggcacc gcccccagga gcctcggcag   1020

 gggcctagga cgccccggcg tgcagaagag aagcgggatc ag   atg gcg tcc cat    1074
                                                  Met Ala Ser His
                                                    1

 gta gag tgc cgt cct ctg gga gtg ttt gag tgt gaa ctc tgt acc ttg     1122
 Val Glu Cys Arg Pro Leu Gly Val Phe Glu Cys Glu Leu Cys Thr Leu
   5                  10                  15                  20

 aca gct ccg tac agc tat gtg gga cag aag ccc ccc aac acc cag tcg     1170
 Thr Ala Pro Tyr Ser Tyr Val Gly Gln Lys Pro Pro Asn Thr Gln Ser
                  25                  30                  35

 atg gtc ctc ctg gag gaa agc tat gtc atg aag gat ccc ttc acc tcc     1218
 Met Val Leu Leu Glu Glu Ser Tyr Val Met Lys Asp Pro Phe Thr Ser
              40                  45                  50

 gac aag gac aga ttc ctg gtc ctc ggc tcg tgc tgc agt ttg tgc agc     1266
 Asp Lys Asp Arg Phe Leu Val Leu Gly Ser Cys Cys Ser Leu Cys Ser
          55                  60                  65

 agg ctg gtg tgt gtg ggc ccg gaa tgc agt tta ttc tac tcc aag aga     1314
 Arg Leu Val Cys Val Gly Pro Glu Cys Ser Leu Phe Tyr Ser Lys Arg
      70                  75                  80

 ttc tgc ctc cct tgt gtc cgg gag aac atc aat gct ttt cct cag gaa     1362
 Phe Cys Leu Pro Cys Val Arg Glu Asn Ile Asn Ala Phe Pro Gln Glu
  85                  90                  95                 100

 att cgg caa gac ttg gag aaa agg aaa gct cca tca aag agg acc ccc     1410
 Ile Arg Gln Asp Leu Glu Lys Arg Lys Ala Pro Ser Lys Arg Thr Pro
                 105                 110                 115

 agc cag ccc ggt tct cgg acg tga gtgcaactgg ggctaggtca tcgggcggca    1464
 Ser Gln Pro Gly Ser Arg Thr 
             120

 ccctgcacag agctcctggg ccagcctgcg ccagggatgc tgctgagctg ggagccgcca   1524

 tgcctggcct tgtttctgga ccactgggag cagcactgca gcccagggga gctggagtcc   1584

 agcttggagc agccacaggc ccagggagct gtagcaagag ggtagtccaa aggcagatgc   1644

 cagacaagac acagccagga acccggccag gtccccccac atgcccctca gggcccaggc   1704

 ctgagtgagt gctgctcaga tgtgactgag agggatgacc tccttcagca gggcagctcc   1764

 taagaggctg cgtgcaggtg cgtgtggggg gagatgccac actgtgtcgg ggccatggtg   1824

 cactgtaggt ggctgcaatg gtctctctgt aaggaaaatc actgacagca gctccttctg   1884

 gacccagtct ggaaggtcta gagggggata gaatttttat ttcatatcct tatgtggtgc   1944

 ttggaaaatg tttttaacct tgaccatgta ttatgtttat aattaaaaac ccaaagaacc   2004

 agctcatgtt tggaaaagga atcttccact gaaacatttg gatacccgac gttctccctg   2064

 gacacttggc ccggcaatag ttggggtctc ctgggaagct gagtgctggc ttctagcctc   2124

 tccagttccc tcagactctg tcttcagctc gggcccctcc gttctgtctc cctcgactcc   2184

 aagtcaggaa taccgtgggc ttcctgccct caccccacac ctcaagacca tcccactgct   2244

 tgcctgcttg ccccctgcca tctcgcactc agccctgggt gcctgtgaag cctggcccca   2304

 ctgcctgccg ggggttcctg cagcaccccc ctactccagg ctccccatct ccctgaagct   2364

 tccagggtag cagctggtgg gacactgatc tgtgagctct ggaatgtctg cttagaattc   2424

 tgagaggcag gaactgctct gtctttgtaa ctactcaagg ccaactgtca catgaaggaa   2484

 tgaataaaga gtttttactg aaaaaaaaaa aa                                 2516




      <210> 28
      <211> 1208
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (299)..(1018)

      <400> 28
 aaaaataatg gttgtacgga cttctgaccg ctcattattt ggcaaaaaac ctaataggtg     60

 tgaggtagtt tcaaattctc aaaaaaaaag tttatagtgt attggggaga caaaccccaa    120

 atgagtcata gtgaaggttg gagtagaatg ggtagagttt gagaggaagg cctgtatctt    180

 accgggggag ggattgtagt ctggggagcc cagcccattc atgtacaggt tcattattga    240

 cttgttagag agatgactgg tgaaatgcct ttttttatct acaaaaaaat atttttag      298                                                                 
 atg gcg ggt gaa aaa gtt gag aag cca gat act aaa gag aag aaa ccc      346
 Met Ala Gly Glu Lys Val Glu Lys Pro Asp Thr Lys Glu Lys Lys Pro
   1               5                  10                  15

 gaa gcc aag aag gtt gat gct ggt ggc aag gtg aaa aag ggt aac ctc      394
 Glu Ala Lys Lys Val Asp Ala Gly Gly Lys Val Lys Lys Gly Asn Leu
              20                  25                  30

 aaa gct aaa aag ccc aag aag ggg aag ccc cat tgc agc cgc aac cct      442
 Lys Ala Lys Lys Pro Lys Lys Gly Lys Pro His Cys Ser Arg Asn Pro
          35                  40                  45

 gtc ctt gtc aga gga att ggc agg tat tcc cga tct gcc atg tat tcc      490
 Val Leu Val Arg Gly Ile Gly Arg Tyr Ser Arg Ser Ala Met Tyr Ser
      50                  55                  60

 aga aag gcc atg tac aag agg aag tac tca gcc gct aaa tcc aag gtt      538
 Arg Lys Ala Met Tyr Lys Arg Lys Tyr Ser Ala Ala Lys Ser Lys Val
  65                  70                  75                  80

 gaa aag aaa aag aag gag aag gtt ctc gca act gtt aca aaa cca gtt      586
 Glu Lys Lys Lys Lys Glu Lys Val Leu Ala Thr Val Thr Lys Pro Val
                  85                  90                  95

 ggt ggt gac aag aac ggc ggt acc cgg gtg gtt aaa ctt cgc aaa atg      634
 Gly Gly Asp Lys Asn Gly Gly Thr Arg Val Val Lys Leu Arg Lys Met
             100                 105                 110

 cct aga tat tat cct act gaa gat gtg cct cga aag ctg ttg agc cac      682
 Pro Arg Tyr Tyr Pro Thr Glu Asp Val Pro Arg Lys Leu Leu Ser His
         115                 120                 125

 ggc aaa aaa ccc ttc agt cag cac gtg aga aaa ctg cga gcc agc att      730
 Gly Lys Lys Pro Phe Ser Gln His Val Arg Lys Leu Arg Ala Ser Ile
     130                 135                 140

 acc ccc ggg acc att ctg atc atc ctc act gga cgc cac agg ggc aag      778
 Thr Pro Gly Thr Ile Leu Ile Ile Leu Thr Gly Arg His Arg Gly Lys
 145                 150                 155                 160

 agg gtg gtt ttc ctg aag cag ctg gct agt ggc tta tta ctt gtg act      826
 Arg Val Val Phe Leu Lys Gln Leu Ala Ser Gly Leu Leu Leu Val Thr
                 165                 170                 175

 gga cct ctg gtc ctc aat cga gtt cct cta cga aga aca cac cag aaa      874
 Gly Pro Leu Val Leu Asn Arg Val Pro Leu Arg Arg Thr His Gln Lys
             180                 185                 190

 ttt gtc att gcc act tca acc aaa atc gat atc agc aat gta aaa atc      922
 Phe Val Ile Ala Thr Ser Thr Lys Ile Asp Ile Ser Asn Val Lys Ile
         195                 200                 205

 cca aaa cat ctt act gat gct tac ttc aag aag aag aag ctg cgg aag      970
 Pro Lys His Leu Thr Asp Ala Tyr Phe Lys Lys Lys Lys Leu Arg Lys
     210                 215                 220

 ccc aga cac cag gaa ggt gag atc ttc gac aga aaa aga gaa ata tga     1018
 Pro Arg His Gln Glu Gly Glu Ile Phe Asp Arg Lys Arg Glu Ile 
 225                 230                 235

 gattacggag cagcgcaaga ttgatcagaa agctgtggac tcacaaattt taccaaaaat   1078

 caaagctatt cctcagctcc agggctacct gcgatctgtg tttgctctga cgaatggaat   1138

 ttatcctcac aaattggtgt tctaaatgtc ttaagaacct aattaaatag ctgactacaa   1198

 aaaaaaaaaa                                                          1208




      <210> 29
      <211> 1386
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (576)..(1175)

      <400> 29
 ttaactagtt gggcattcca ccacaacact gttgatgcca tccatgatgt catgagggtg     60

 gtggccatca acattgcaga cacagactgg gcagtagtca gtccccagga gctctttaat    120

 agttccagag agttctctgg ctaaagattg gtgctgcatc tgtcgagcag tgttgacaat    180

 ctcatcaaaa gtgatattcc cactgtgttt aatgtttttc tgtttctttc tgtctcttgg    240

 tggttccttg agggctttga tgatcagggc agaggcagaa ggcaccacct caatctgggc    300

 ctgtctgttc tgaatggtca gtttcactgt aatcctcagg cccttccagt cacccgttgc    360

 cttggcaatg tcatcaccaa ctttttttgg agacagaccc agggggccga tcttgggggc    420

 cagggcagaa gtggcaccga cttcacctcc ggtgcacctc aggtatacga ctttgatctc    480

 gttggggtcg aacttcggcg gctcggagga ggccaaggtg caacttcctt cggtcgtccc    540

 gaatccgggt tcatccgaca ccagccgcct ccacc   atg ccg ccg aag ttc gac     593
                                          Met Pro Pro Lys Phe Asp
                                            1               5

 ccc aac gag atc aaa gtc gta tac ctg agg tgc acc gga ggt gaa gtc      641
 Pro Asn Glu Ile Lys Val Val Tyr Leu Arg Cys Thr Gly Gly Glu Val
              10                  15                  20

 ggt gcc act tct gcc ctg gcc ccc aag atc ggc ccc ctg ggt ctg tct      689
 Gly Ala Thr Ser Ala Leu Ala Pro Lys Ile Gly Pro Leu Gly Leu Ser
          25                  30                  35

 cca aaa aaa gtt ggt gat gac att gcc aag gca acg ggt gac tgg aag      737
 Pro Lys Lys Val Gly Asp Asp Ile Ala Lys Ala Thr Gly Asp Trp Lys
      40                  45                  50

 ggc ctg agg att aca gtg aaa ctg acc att cag aac aga cag gcc cag      785
 Gly Leu Arg Ile Thr Val Lys Leu Thr Ile Gln Asn Arg Gln Ala Gln
  55                  60                  65                  70

 att gag gtg gtg cct tct gcc tct gcc ctg atc atc aaa gcc ctc aag      833
 Ile Glu Val Val Pro Ser Ala Ser Ala Leu Ile Ile Lys Ala Leu Lys
                  75                  80                  85

 gaa cca cca aga gac aga aag aaa cag aaa aac att aaa cac agt ggg      881
 Glu Pro Pro Arg Asp Arg Lys Lys Gln Lys Asn Ile Lys His Ser Gly
              90                  95                 100

 aat atc act ttt gat gag att gtc aac att gct cga cag atg cgg cac      929
 Asn Ile Thr Phe Asp Glu Ile Val Asn Ile Ala Arg Gln Met Arg His
         105                 110                 115

 cga tcc tta gcc aga gaa ctc tct gga acc att aaa gag atc ctg ggg      977
 Arg Ser Leu Ala Arg Glu Leu Ser Gly Thr Ile Lys Glu Ile Leu Gly
     120                 125                 130

 act gcc cag tca gtg ggc tgt aat gtt gat ggc cgc cat cct cat gac     1025
 Thr Ala Gln Ser Val Gly Cys Asn Val Asp Gly Arg His Pro His Asp
 135                 140                 145                 150

 atc atc gat gac atc aac agt ggt gct gtg gaa tgc cca gct gta agt     1073
 Ile Ile Asp Asp Ile Asn Ser Gly Ala Val Glu Cys Pro Ala Val Ser
                 155                 160                 165

 gac att ttc att gtt aca gta ggg gtg aaa ggg ggg ccc ccc agt gta     1121
 Asp Ile Phe Ile Val Thr Val Gly Val Lys Gly Gly Pro Pro Ser Val
             170                 175                 180

 ttc cca gag ata agc tgg gaa gtt ttg gaa atg gtt act ggt ggg gtg     1169
 Phe Pro Glu Ile Ser Trp Glu Val Leu Glu Met Val Thr Gly Gly Val
         185                 190                 195

 gga taa tccttttaaa ctttttactg attttttttt tctttcccac agagttaagc      1225
 Gly 


 acaaaggaaa acatttcaat aaaggatcat ttgacaactg gtggattttc tggtgtggcg   1285

 tcttccttga gggagctagc tcctttgtgg ggtggtcagt ggggtcaggg tggcagaacc   1345

 tgtggagaag taacaagcac cttgtggtgg gtaaaaaaaa a                       1386




      <210> 30
      <211> 1917
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(1784)

      <400> 30
 gcgggtgtca ctctttattg cggggtccac actgtgggtg ctggggcccc tcccactgag     60

 ggaaggctga gcctctagcc agggctgac  atg ttg agg act acg cgc ggc cca     113
                                  Met Leu Arg Thr Thr Arg Gly Pro
                                    1               5

 ggc ctg ggc ccc ccg ctg ctc cag gcc gcg ctg ggc ctt ggg cgg gct      161
 Gly Leu Gly Pro Pro Leu Leu Gln Ala Ala Leu Gly Leu Gly Arg Ala
      10                  15                  20

 ggg tgg cac tgg cct gcg ggc cgg gcg gcg agc ggg ggg cgc ggg cgg      209
 Gly Trp His Trp Pro Ala Gly Arg Ala Ala Ser Gly Gly Arg Gly Arg
  25                  30                  35                  40

 gcc tgg ctg cag ccc acg ggc cgg gag acg ggt gtg cag gtg tac aac      257
 Ala Trp Leu Gln Pro Thr Gly Arg Glu Thr Gly Val Gln Val Tyr Asn
                  45                  50                  55

 agc ctc acc ggg agg aag gaa ccc cta atc gtg gcg cac gcc gaa gcc      305
 Ser Leu Thr Gly Arg Lys Glu Pro Leu Ile Val Ala His Ala Glu Ala
              60                  65                  70

 gcc tcc tgg tat agc tgt gga cca act gta tat gat cat gcg cac ctt      353
 Ala Ser Trp Tyr Ser Cys Gly Pro Thr Val Tyr Asp His Ala His Leu
          75                  80                  85

 ggc cat gct tgc tca tat gtt aga ttt gat atc att cga agg atc cta      401
 Gly His Ala Cys Ser Tyr Val Arg Phe Asp Ile Ile Arg Arg Ile Leu
      90                  95                 100

 acc aag gtt ttt gga tgc agc ata gtc atg gtg atg ggt att aca gat      449
 Thr Lys Val Phe Gly Cys Ser Ile Val Met Val Met Gly Ile Thr Asp
 105                 110                 115                 120

 gta gat gat aaa atc atc aaa aga gcc aat gag atg aat att tcc ccc      497
 Val Asp Asp Lys Ile Ile Lys Arg Ala Asn Glu Met Asn Ile Ser Pro
                 125                 130                 135

 gct tcc ctc gcc agt ctt tat gag gaa gac ttc aag cag gac atg gca      545
 Ala Ser Leu Ala Ser Leu Tyr Glu Glu Asp Phe Lys Gln Asp Met Ala
             140                 145                 150

 gcc ctg aag gtt ctc cca ccc acg gtg tac ctg agg gta acc gaa aat      593
 Ala Leu Lys Val Leu Pro Pro Thr Val Tyr Leu Arg Val Thr Glu Asn
         155                 160                 165

 att cct cag ata att tct ttc att gaa gga atc att gct cgt ggg aac      641
 Ile Pro Gln Ile Ile Ser Phe Ile Glu Gly Ile Ile Ala Arg Gly Asn
     170                 175                 180

 gct tat tca acg gca aaa ggc aat gtc tac ttc gat ctg aag tct aga      689
 Ala Tyr Ser Thr Ala Lys Gly Asn Val Tyr Phe Asp Leu Lys Ser Arg
 185                 190                 195                 200

 gga gac aag tat ggc aaa ttg gtc ggc gtg gtc cct ggt cca gtc gga      737
 Gly Asp Lys Tyr Gly Lys Leu Val Gly Val Val Pro Gly Pro Val Gly
                 205                 210                 215

 gag cca gcg gac tct gac aag cgt cat gcc agt gac ttc gcc ctg tgg      785
 Glu Pro Ala Asp Ser Asp Lys Arg His Ala Ser Asp Phe Ala Leu Trp
             220                 225                 230

 aag gcg gcc aaa ccc cag gag gtg ttc tgg gcc tct ccc tgg gga ccc      833
 Lys Ala Ala Lys Pro Gln Glu Val Phe Trp Ala Ser Pro Trp Gly Pro
         235                 240                 245

 ggg agg ccg ggc tgg cac atc gag tgc tct gcc atc gct agt atg gta      881
 Gly Arg Pro Gly Trp His Ile Glu Cys Ser Ala Ile Ala Ser Met Val
     250                 255                 260

 ttt gga agt caa ctg gat atc cat tca ggt ggg ata gat tta gct ttt      929
 Phe Gly Ser Gln Leu Asp Ile His Ser Gly Gly Ile Asp Leu Ala Phe
 265                 270                 275                 280

 cca cat cat gag aac gaa att gca cag tgc gaa gtc ttt cat cag tgc      977
 Pro His His Glu Asn Glu Ile Ala Gln Cys Glu Val Phe His Gln Cys
                 285                 290                 295

 gag cag tgg gga aat tat ttt ctg cat tct ggg cat ttg cac gcc aaa     1025
 Glu Gln Trp Gly Asn Tyr Phe Leu His Ser Gly His Leu His Ala Lys
             300                 305                 310

 ggc aaa gaa gaa aaa atg tcc aaa tca tta aag aac tac att act att     1073
 Gly Lys Glu Glu Lys Met Ser Lys Ser Leu Lys Asn Tyr Ile Thr Ile
         315                 320                 325

 aag gac ttt ctg aag acc ttt tcc ccc gat gtc ttc cgg ttc ttc tgc     1121
 Lys Asp Phe Leu Lys Thr Phe Ser Pro Asp Val Phe Arg Phe Phe Cys
     330                 335                 340

 ctg cgg agc agc tac cgc tca gcc atc gac tac agt gac agc gcc atg     1169
 Leu Arg Ser Ser Tyr Arg Ser Ala Ile Asp Tyr Ser Asp Ser Ala Met
 345                 350                 355                 360

 ctc caa gct cag cag ctg ctc ctg ggg ctg ggc tct ttc ctg gag gac     1217
 Leu Gln Ala Gln Gln Leu Leu Leu Gly Leu Gly Ser Phe Leu Glu Asp
                 365                 370                 375

 gca cgt gcc tac atg aag ggg cag ctg gcc tgc ggc tcc gtc agg gaa     1265
 Ala Arg Ala Tyr Met Lys Gly Gln Leu Ala Cys Gly Ser Val Arg Glu
             380                 385                 390

 gcg atg ctg tgg gag agg ctc tcc agc acc aag agg gcc gtg aag gcg     1313
 Ala Met Leu Trp Glu Arg Leu Ser Ser Thr Lys Arg Ala Val Lys Ala
         395                 400                 405

 gcc ttg gca gat gac ttt gac aca ccc agg gtg gtt gat gcc atc ctg     1361
 Ala Leu Ala Asp Asp Phe Asp Thr Pro Arg Val Val Asp Ala Ile Leu
     410                 415                 420

 ggc ctt gca cac cac ggg aat gga cag ctc agg gcg tcc ctg aag gaa     1409
 Gly Leu Ala His His Gly Asn Gly Gln Leu Arg Ala Ser Leu Lys Glu
 425                 430                 435                 440

 cct gaa ggg ccg aga agt cct gct gtg ttt ggt gcc atc atc tct tac     1457
 Pro Glu Gly Pro Arg Ser Pro Ala Val Phe Gly Ala Ile Ile Ser Tyr
                 445                 450                 455

 ttt gaa cag ttt ttt gaa act gtt gga att tct ctg gca aat caa cag     1505
 Phe Glu Gln Phe Phe Glu Thr Val Gly Ile Ser Leu Ala Asn Gln Gln
             460                 465                 470

 tac gtt tca gga gac ggc agc gag gct acc ttg cat ggt gtg gtg gac     1553
 Tyr Val Ser Gly Asp Gly Ser Glu Ala Thr Leu His Gly Val Val Asp
         475                 480                 485

 gag ctg gtg cgg ttc cgg cag aag gtc cgg cag ttt gcg ctg gcc atg     1601
 Glu Leu Val Arg Phe Arg Gln Lys Val Arg Gln Phe Ala Leu Ala Met
     490                 495                 500

 ccc gag gcc acg ggg gac gcc cgg cgg cag cag ctc cta gaa agg cag     1649
 Pro Glu Ala Thr Gly Asp Ala Arg Arg Gln Gln Leu Leu Glu Arg Gln
 505                 510                 515                 520

 ccc ctg ctg gaa gca tgc gac acc ctg cgc cgg ggc ctg act gcc cac     1697
 Pro Leu Leu Glu Ala Cys Asp Thr Leu Arg Arg Gly Leu Thr Ala His
                 525                 530                 535

 ggc atc aac atc aag gac aga agc agt aca aca tcc acg tgg gaa ctg     1745
 Gly Ile Asn Ile Lys Asp Arg Ser Ser Thr Thr Ser Thr Trp Glu Leu
             540                 545                 550

 ctg gat caa agg aca aaa gac caa aaa tca gcg ggc tga ggatggagca      1794
 Leu Asp Gln Arg Thr Lys Asp Gln Lys Ser Ala Gly 
         555                 560

 cagccatgaa cctgctcacg acaagacgca cccatgcttc tcagggtcaa ggctttatgt   1854

 taaagcttcc tgtcggggct gctaggtcag cattaaagta aggcaaccaa caaaaaaaaa   1914

 aaa                                                                 1917




      <210> 31
      <211> 2205
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(2205)

      <400> 31
 atttaccgca tttacggctg cattctctct gtccccagca agcgggtccc acctttcccg     60

 gtcccagccc cacgcaccgc cgctcggaac tacacttccc ggcagaacgc gggcgcgcgc    120

 acgcgcaccg gggcctcagc c  atg gcg acc gtg ctg tcc agg gcg ctc aag     171
                          Met Ala Thr Val Leu Ser Arg Ala Leu Lys
                            1               5                  10

 ctg ccg ggg aag aag agc cca gac cta ggg gag tat gat cca ctt acc      219
 Leu Pro Gly Lys Lys Ser Pro Asp Leu Gly Glu Tyr Asp Pro Leu Thr
                  15                  20                  25

 cag gct gac agt gat gag agc gaa gac gat ctg gtg ctt aac ctg cag      267
 Gln Ala Asp Ser Asp Glu Ser Glu Asp Asp Leu Val Leu Asn Leu Gln
              30                  35                  40

 aag aat gga ggg gtc aaa aat ggg aag agt cct ttg gga gaa gcg cca      315
 Lys Asn Gly Gly Val Lys Asn Gly Lys Ser Pro Leu Gly Glu Ala Pro
          45                  50                  55

 gaa ccc gac tca gat gct gag gtt gca gag gct gca aag cca cat ctt      363
 Glu Pro Asp Ser Asp Ala Glu Val Ala Glu Ala Ala Lys Pro His Leu
      60                  65                  70

 tca gaa gtc acc acg gag ggc tac ccc tca gaa ccc ctt ggg ggc ctg      411
 Ser Glu Val Thr Thr Glu Gly Tyr Pro Ser Glu Pro Leu Gly Gly Leu
  75                  80                  85                  90

 gaa cag aag gcg gcc tcc tcc ctg gtg tca tat gtg cgc acg tct gtc      459
 Glu Gln Lys Ala Ala Ser Ser Leu Val Ser Tyr Val Arg Thr Ser Val
                  95                 100                 105

 ttc ctg ctg act ttg ggg atc tcg atg atc ctg gtg ctc ctg tgt gct      507
 Phe Leu Leu Thr Leu Gly Ile Ser Met Ile Leu Val Leu Leu Cys Ala
             110                 115                 120

 ttc ctg atc ccc tgt cct ccc aga gat ctg cac agc acc tgg agc cgc      555
 Phe Leu Ile Pro Cys Pro Pro Arg Asp Leu His Ser Thr Trp Ser Arg
         125                 130                 135

 cac ttg ggc tcc cag gga gag ttg tct tat gtt tgt ttt atg tac agt      603
 His Leu Gly Ser Gln Gly Glu Leu Ser Tyr Val Cys Phe Met Tyr Ser
     140                 145                 150

 gtc cag ggc ttt tcc atg cac tta gca ggg gga gta ggg aga ggt gtg      651
 Val Gln Gly Phe Ser Met His Leu Ala Gly Gly Val Gly Arg Gly Val
 155                 160                 165                 170

 tct act ata cct agt cga gga act gga gtc tgc ctg gtg ttt ata gag      699
 Ser Thr Ile Pro Ser Arg Gly Thr Gly Val Cys Leu Val Phe Ile Glu
                 175                 180                 185

 cta ctg gca aca gag aac tgg ttt gtg gta act tgc tca gga cct ttt      747
 Leu Leu Ala Thr Glu Asn Trp Phe Val Val Thr Cys Ser Gly Pro Phe
             190                 195                 200

 tgg ttt ttt atg tgt ata aca ggt ggg gac ctg tct cca ttg gaa ttg      795
 Trp Phe Phe Met Cys Ile Thr Gly Gly Asp Leu Ser Pro Leu Glu Leu
         205                 210                 215

 gct gat gtg aat gga gat ggc ctg cgt gat gtg ctt ctc tcc ttt gtg      843
 Ala Asp Val Asn Gly Asp Gly Leu Arg Asp Val Leu Leu Ser Phe Val
     220                 225                 230

 atg tca agg aac ggg agt gca gta ggt gtc tca aga cca gct gct aat      891
 Met Ser Arg Asn Gly Ser Ala Val Gly Val Ser Arg Pro Ala Ala Asn
 235                 240                 245                 250

 ctt gta tgc ctt tcg ggg atg aat ggc agc aca ctg tgg tct agt ctt      939
 Leu Val Cys Leu Ser Gly Met Asn Gly Ser Thr Leu Trp Ser Ser Leu
                 255                 260                 265

 ctc cct gag gag gct cga gat atc aca tgt ttg gag ctg atg cca gga      987
 Leu Pro Glu Glu Ala Arg Asp Ile Thr Cys Leu Glu Leu Met Pro Gly
             270                 275                 280

 agc ttg gct gaa acc atc tgc ctt gtg aca ggg aca cac aag atg ctc     1035
 Ser Leu Ala Glu Thr Ile Cys Leu Val Thr Gly Thr His Lys Met Leu
         285                 290                 295

 agc gca ttc aat gca acg tca ggg aaa gcc att tgg act tta aac cca     1083
 Ser Ala Phe Asn Ala Thr Ser Gly Lys Ala Ile Trp Thr Leu Asn Pro
     300                 305                 310

 aac tac ttg tcc aac ggt acc ttg gct gcc cca gtt gtg gta ctg cca     1131
 Asn Tyr Leu Ser Asn Gly Thr Leu Ala Ala Pro Val Val Val Leu Pro
 315                 320                 325                 330

 gac ttg gat gaa gac ggt gtt cga gac ctt gtg gtt ctg gcc att ggg     1179
 Asp Leu Asp Glu Asp Gly Val Arg Asp Leu Val Val Leu Ala Ile Gly
                 335                 340                 345

 gaa ttg cag cca gat ctg tgc ttt ctg ctg gtg tct ggc cgg acc gga     1227
 Glu Leu Gln Pro Asp Leu Cys Phe Leu Leu Val Ser Gly Arg Thr Gly
             350                 355                 360

 aat cca gtg ggt cga cct gtg aag tac aac atc gtt gga gtt ggg aat     1275
 Asn Pro Val Gly Arg Pro Val Lys Tyr Asn Ile Val Gly Val Gly Asn
         365                 370                 375

 ctg att ggt cct cag gtt tac atc acc aca aat ggg gct gtc tac atc     1323
 Leu Ile Gly Pro Gln Val Tyr Ile Thr Thr Asn Gly Ala Val Tyr Ile
     380                 385                 390

 ctg ttt ggc ttt gga aat ata caa gct gtc gca ctg cgg gac att ttt     1371
 Leu Phe Gly Phe Gly Asn Ile Gln Ala Val Ala Leu Arg Asp Ile Phe
 395                 400                 405                 410

 gtt cag gcc caa aat cga gac agc tca cca cct tct ctg cag ata gaa     1419
 Val Gln Ala Gln Asn Arg Asp Ser Ser Pro Pro Ser Leu Gln Ile Glu
                 415                 420                 425

 gag cca gaa tgg gaa aag cga aga tcc atc aac ctg tct gag ctc att     1467
 Glu Pro Glu Trp Glu Lys Arg Arg Ser Ile Asn Leu Ser Glu Leu Ile
             430                 435                 440

 gat gtt tac agt gat ggt gtt gaa cta ctc cag atg gtg aag gca cca     1515
 Asp Val Tyr Ser Asp Gly Val Glu Leu Leu Gln Met Val Lys Ala Pro
         445                 450                 455

 gat tcc aac tgc agc aac ctt ctg att aca acc aga caa agc ctt gtg     1563
 Asp Ser Asn Cys Ser Asn Leu Leu Ile Thr Thr Arg Gln Ser Leu Val
     460                 465                 470

 ctg ctt cgg ggg caa aat ctg aca cct tac tgg gca ttg aga ctt caa     1611
 Leu Leu Arg Gly Gln Asn Leu Thr Pro Tyr Trp Ala Leu Arg Leu Gln
 475                 480                 485                 490

 ggc ctg cgc agc cag cct act cct gga tat ttc act gat gat cag aca     1659
 Gly Leu Arg Ser Gln Pro Thr Pro Gly Tyr Phe Thr Asp Asp Gln Thr
                 495                 500                 505

 tta gac ttc ctt ctg cag ata cag gat gga gtt ggg atg aaa aag atg     1707
 Leu Asp Phe Leu Leu Gln Ile Gln Asp Gly Val Gly Met Lys Lys Met
             510                 515                 520

 atg gtt gtg gat ggt gac tct ggc tcc att gtt tgg agt tac cgt gct     1755
 Met Val Val Asp Gly Asp Ser Gly Ser Ile Val Trp Ser Tyr Arg Ala
         525                 530                 535

 ccg tgt cac atg aaa gaa acg cca gcc acc tca gca gtt act tca gac     1803
 Pro Cys His Met Lys Glu Thr Pro Ala Thr Ser Ala Val Thr Ser Asp
     540                 545                 550

 cag aag tct gtc ttc ctc ttc tgg gcc gaa ggg ctg tca gct gca tct     1851
 Gln Lys Ser Val Phe Leu Phe Trp Ala Glu Gly Leu Ser Ala Ala Ser
 555                 560                 565                 570

 ccc aat tcc gat atc atc cta gga act gag ccg ccc agc ctt cac cac     1899
 Pro Asn Ser Asp Ile Ile Leu Gly Thr Glu Pro Pro Ser Leu His His
                 575                 580                 585

 ctt tac ctc ctg cat cct gcg ttc ccc tcc atc ctt ctg gat ctg gcc     1947
 Leu Tyr Leu Leu His Pro Ala Phe Pro Ser Ile Leu Leu Asp Leu Ala
             590                 595                 600

 aac acc acc ggc aca gtg acg gct tca gag gtt gga att aac gac ctc     1995
 Asn Thr Thr Gly Thr Val Thr Ala Ser Glu Val Gly Ile Asn Asp Leu
         605                 610                 615

 tgg aaa gat gcc ttt tat gtt acc agg aca aca ggg cca agc tcc gaa     2043
 Trp Lys Asp Ala Phe Tyr Val Thr Arg Thr Thr Gly Pro Ser Ser Glu
     620                 625                 630

 ggc cat cca gca gcc ctg gtg gtc agc aag ctt agt cta cgg tgg gca     2091
 Gly His Pro Ala Ala Leu Val Val Ser Lys Leu Ser Leu Arg Trp Ala
 635                 640                 645                 650

 cta atg gag ggc cag atg gct cag cta cag gag tcc acc ccc aaa att     2139
 Leu Met Glu Gly Gln Met Ala Gln Leu Gln Glu Ser Thr Pro Lys Ile
                 655                 660                 665

 ggc cgt ggg gag ctg cga aga ttt ctc tct agg ata aag ttt gtt gaa     2187
 Gly Arg Gly Glu Leu Arg Arg Phe Leu Ser Arg Ile Lys Phe Val Glu
             670                 675                 680

 gct ccc tac gag atc taa                                             2205
 Ala Pro Tyr Glu Ile 
         685





      <210> 32
      <211> 1335
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(891)

      <400> 32
 ccggcccggg ccaggacagc gggcggcggg cggcgcgggc ctggccccgg g atg gct      57
                                                          Met Ala
                                                            1

 atg ttc cgc agc ctg gtg gcc tcg gct cag cag cgg cag ccg ccg gcc      105
 Met Phe Arg Ser Leu Val Ala Ser Ala Gln Gln Arg Gln Pro Pro Ala
           5                  10                  15

 ggg ccg gcg ggc ggc gac agc ggc ctg gag gcg cag tac acc tgc ccc      153
 Gly Pro Ala Gly Gly Asp Ser Gly Leu Glu Ala Gln Tyr Thr Cys Pro
      20                  25                  30

 atc tgc ctg gag gtc tat cac cgg ccc gtg gcc atc ggc agc tgc ggc      201
 Ile Cys Leu Glu Val Tyr His Arg Pro Val Ala Ile Gly Ser Cys Gly
  35                  40                  45                  50

 cac acg ttc tgc ggg gag tgt ctc cag ccc tgc ctg cag gtg cca tcc      249
 His Thr Phe Cys Gly Glu Cys Leu Gln Pro Cys Leu Gln Val Pro Ser
                  55                  60                  65

 ccg ctg tgc cca ctg tgc cgc ctg ccc ttc gac ccc aag aag gtg gac      297
 Pro Leu Cys Pro Leu Cys Arg Leu Pro Phe Asp Pro Lys Lys Val Asp
              70                  75                  80

 aag gcc acc cac gtg gag aag cag ctc tca tcc tac aaa gcg ccc tgt      345
 Lys Ala Thr His Val Glu Lys Gln Leu Ser Ser Tyr Lys Ala Pro Cys
          85                  90                  95

 cga ggc tgc aac aaa aag gtg acc ctg gca aag atg aga gtg cac att      393
 Arg Gly Cys Asn Lys Lys Val Thr Leu Ala Lys Met Arg Val His Ile
     100                 105                 110

 tcg tcc tgc ctg aag gtc cag gag cag atg gcc aac tgc ccc aag ttc      441
 Ser Ser Cys Leu Lys Val Gln Glu Gln Met Ala Asn Cys Pro Lys Phe
 115                 120                 125                 130

 gtc ccc gtg gtg ccc aca tca cag cct atc ccc agc aac atc ccc aac      489
 Val Pro Val Val Pro Thr Ser Gln Pro Ile Pro Ser Asn Ile Pro Asn
                 135                 140                 145

 agg tcc acc ttc gcc tgc ccg tac tgt ggt gcc cgc aac ctg gac cag      537
 Arg Ser Thr Phe Ala Cys Pro Tyr Cys Gly Ala Arg Asn Leu Asp Gln
             150                 155                 160

 cag gag ctg gtg aag cac tgt gtg gaa agc cac cgc agc gac ccc aac      585
 Gln Glu Leu Val Lys His Cys Val Glu Ser His Arg Ser Asp Pro Asn
         165                 170                 175

 cgc gtg gtg tgc ccc atc tgc tcg gca atg ccc tgg ggg gac ccc agc      633
 Arg Val Val Cys Pro Ile Cys Ser Ala Met Pro Trp Gly Asp Pro Ser
     180                 185                 190

 tac aag agc gcc aac ttc ctg cag cac ctg ctt cac cga cac aag ttc      681
 Tyr Lys Ser Ala Asn Phe Leu Gln His Leu Leu His Arg His Lys Phe
 195                 200                 205                 210

 tcc tac gac acc ttt gtg gta ggc atc ccg cca gca ccg tcc tcc ccc      729
 Ser Tyr Asp Thr Phe Val Val Gly Ile Pro Pro Ala Pro Ser Ser Pro
                 215                 220                 225

 acg ccc tcc tca tcc acc ctc ctc ctg ctc ggg ccc ctc gcc agc ctc      777
 Thr Pro Ser Ser Ser Thr Leu Leu Leu Leu Gly Pro Leu Ala Ser Leu
             230                 235                 240

 agg gtc cgc agg gtt cag agg aag cca gaa aca gaa gcc tcg ttt cag      825
 Arg Val Arg Arg Val Gln Arg Lys Pro Glu Thr Glu Ala Ser Phe Gln
         245                 250                 255

 gac tac agt att gac gag gag gcc gcc ttc cag gct gct ctg gcc ctg      873
 Asp Tyr Ser Ile Asp Glu Glu Ala Ala Phe Gln Ala Ala Leu Ala Leu
     260                 265                 270

 tct ctc tct gag aac tga agggaa gcgcagccac ctgcctgcgt ctggggtcag      927
 Ser Leu Ser Glu Asn 
 275

 ggatgtcccc gctcctgtgt cgcacctggc acctgctcgg gagtgcacct caccggattg    987

 agctcaggcg agccatgggg tttgctgtgg ggtctgccct ggccacccac tgtgtgtttg   1047

 ggtccttgag gtttgtacgt ttctctttga tgaccaggaa gaaatcccag caccccagcc   1107

 acaggctgtg gttgctccca gcaaaggcgg ggccggcaaa aaaggggcct cctccaccca   1167

 aagtcctggc cttggcccgc tgtcaccttc aaagctgact gtgccccgct gcgggagggg   1227

 acggcacccc agtggtggca aagcttgggg gcctgggcag gggcccgctt ggcgggccgg   1287

 gcaacacgtc aacattcttt tctgttcttg gcattaatta ttgctgtc                1335




      <210> 33
      <211> 1397
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (645)..(1379)

      <400> 33
 tgttaggcct tctcaagtgg gaatcaggaa cgctgctgtg ctctagagat gttttgttct     60

 tcctgtaggg ctgaagcagt gcctactcga tagaatcagt catcatgcaa ataaaagcca    120

 cctgagtcaa aggcaaagcc agagtgcagc ttggagcaaa gaagttaaaa gcatattggc    180

 agaggaagag ccctggcatt ccagcaggag ctaacaggaa aaagaaaatc aatggcagta    240

 gccctgacac agccacttct ggtggttacc actcacctgg ggattcagca acaggtatct    300

 acggggaggg ccgtgcatcc tctactaccc tggaggatct ggagagccag taccaagaac    360

 tagcagtggc cctggattca agctccgcaa taatcagtca actcactgaa aacatcaatt    420

 cactggttcg cacatctaag gaggagaaga agcatgagat acatctggta cagaagcttg    480

 ggaggagctt gttcaaactc aaaaaccaga cggctgaacc cctggcccca cagcccccag    540

 cagggccatc taaggtggag cagctacaag atgagaccaa ccacctaagg aaggagctag    600

 agagtgtggg aagacagctc caggctgagg tggaaaacaa tcag atg ttg agt ctc     656
                                                  Met Leu Ser Leu
                                                    1

 ctg aac agg aga cag gag gag agg cta cgt gaa cag gag gag agg cta      704
 Leu Asn Arg Arg Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu
   5                  10                  15                  20

 cgt gaa cag gag gag agg ctg tgt gaa cag gag gag agg ctg tgt gaa      752
 Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu Glu Arg Leu Cys Glu
                  25                  30                  35

 cag gag gag agg cta cgt gaa cag gag gag agg ctg tgt gaa cag gag      800
 Gln Glu Glu Arg Leu Arg Glu Gln Glu Glu Arg Leu Cys Glu Gln Glu
              40                  45                  50

 aag ctg cca ggg cag gag agg ctg ctg gaa gag gtg gag aag ctg tta      848
 Lys Leu Pro Gly Gln Glu Arg Leu Leu Glu Glu Val Glu Lys Leu Leu
          55                  60                  65

 gaa cag gag agg cgg cag gag gag cag gag agg ctg ctg gag agg gag      896
 Glu Gln Glu Arg Arg Gln Glu Glu Gln Glu Arg Leu Leu Glu Arg Glu
      70                  75                  80

 agg ctg ctg gac gag gtg gag gag ctc ctg gag cag gag agg ctt cgg      944
 Arg Leu Leu Asp Glu Val Glu Glu Leu Leu Glu Gln Glu Arg Leu Arg
  85                  90                  95                 100

 caa cag gat gag agg ctg tgg cag cag gag act ctg cgg gag ctg gag      992
 Gln Gln Asp Glu Arg Leu Trp Gln Gln Glu Thr Leu Arg Glu Leu Glu
                 105                 110                 115

 agg ttg cgg gag ctg gag agg atg ctg gag ctg ggg tgg gaa gcc ctg     1040
 Arg Leu Arg Glu Leu Glu Arg Met Leu Glu Leu Gly Trp Glu Ala Leu
             120                 125                 130

 tac gag cag cgg gcc gag cca cgc agc ggc ttc gag gag ctg aac aac     1088
 Tyr Glu Gln Arg Ala Glu Pro Arg Ser Gly Phe Glu Glu Leu Asn Asn
         135                 140                 145

 gag aac aag agc aca ctg cag ttg gag cag caa gta aag gag ctg gag     1136
 Glu Asn Lys Ser Thr Leu Gln Leu Glu Gln Gln Val Lys Glu Leu Glu
     150                 155                 160

 aag tcg ggt gga gct gaa gag cca aga ggc tcc gag tct gca gca gca     1184
 Lys Ser Gly Gly Ala Glu Glu Pro Arg Gly Ser Glu Ser Ala Ala Ala
 165                 170                 175                 180

 gcc aga cca gta cct gga gcc cca gtc cca caa gga gct tgg atg tgc     1232
 Ala Arg Pro Val Pro Gly Ala Pro Val Pro Gln Gly Ala Trp Met Cys
                 185                 190                 195

 gga caa gca ggg tgg act ccc cag gag cac cca ggc ttg agt gga gaa     1280
 Gly Gln Ala Gly Trp Thr Pro Gln Glu His Pro Gly Leu Ser Gly Glu
             200                 205                 210

 gct gtt ggt aca gga gag gcg gca gga gga gca gga gag gct gca tgc     1328
 Ala Val Gly Thr Gly Glu Ala Ala Gly Gly Ala Gly Glu Ala Ala Cys
         215                 220                 225

 cat tct ttt cgg gct gcc gag aac agg gag cta aac atc acc atc atc     1376
 His Ser Phe Arg Ala Ala Glu Asn Arg Glu Leu Asn Ile Thr Ile Ile
     230                 235                 240

 taa gagcgggtca agaaattg                                             1397
 






      <210> 34
      <211> 1799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(831)

      <400> 34
 aatttgtaca ctcctatagg gaatttggtc tcgagcagta attcggcacg aggtattttg     60

 atgttatatt agcattcctg ttgctgattt tctgtcttga gggaaaaagt tattcaggag    120

 agt  atg ttg atc ttg gtt cat aat cca tct cca ggg tcg acg att tcg     168
      Met Leu Ile Leu Val His Asn Pro Ser Pro Gly Ser Thr Ile Ser
        1               5                  10                  15

 tcg ggc ggc cag ggc cgc cgg agg aag cag ccc ccc atg ccg gcc gac      216
 Ser Gly Gly Gln Gly Arg Arg Arg Lys Gln Pro Pro Met Pro Ala Asp
                  20                  25                  30

 ttc aag ttg cag gtc atc att atc ggc tcc cgc ggc gtg ggc aag acc      264
 Phe Lys Leu Gln Val Ile Ile Ile Gly Ser Arg Gly Val Gly Lys Thr
              35                  40                  45

 agc ctg atg gag cgc ttc acc gac gac acc ttc tgc gag gcc tgc aag      312
 Ser Leu Met Glu Arg Phe Thr Asp Asp Thr Phe Cys Glu Ala Cys Lys
          50                  55                  60

 tcc acc gtg ggt gtt gac ttc aaa atc aaa act gta gag cta aga gga      360
 Ser Thr Val Gly Val Asp Phe Lys Ile Lys Thr Val Glu Leu Arg Gly
      65                  70                  75

 aag aaa att aga tta cag atc tgg gac aca gca ggt cag gag aga ttc      408
 Lys Lys Ile Arg Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg Phe
  80                  85                  90                  95

 aac agc att acc tca gct tat tac aga agt gcc aag ggg atc ata tta      456
 Asn Ser Ile Thr Ser Ala Tyr Tyr Arg Ser Ala Lys Gly Ile Ile Leu
                 100                 105                 110

 gta tat gat atc act aag aag gag aca ttt gat gat ttg ccg aaa tgg      504
 Val Tyr Asp Ile Thr Lys Lys Glu Thr Phe Asp Asp Leu Pro Lys Trp
             115                 120                 125

 atg aag atg att gat aag tat gct tca gaa gat gca gag ctt ctc tta      552
 Met Lys Met Ile Asp Lys Tyr Ala Ser Glu Asp Ala Glu Leu Leu Leu
         130                 135                 140

 gtt gga aat aag ttg gac tgt gaa acg gac aga gaa atc acc agg cag      600
 Val Gly Asn Lys Leu Asp Cys Glu Thr Asp Arg Glu Ile Thr Arg Gln
     145                 150                 155

 cag ggg gaa aag ttt gca cag cag atc act ggg atg cgg ttc tgt gaa      648
 Gln Gly Glu Lys Phe Ala Gln Gln Ile Thr Gly Met Arg Phe Cys Glu
 160                 165                 170                 175

 gca agt gcc aag gat aac ttc aat gtg gac gag ata ttt ttg aaa ctt      696
 Ala Ser Ala Lys Asp Asn Phe Asn Val Asp Glu Ile Phe Leu Lys Leu
                 180                 185                 190

 gtc gat gac att ctg aaa aag atg cct ctg gat att tta agg aat gag      744
 Val Asp Asp Ile Leu Lys Lys Met Pro Leu Asp Ile Leu Arg Asn Glu
             195                 200                 205

 ttg tcc aat agt atc ctg tcg tta caa cca gag cct gag ata ccg cca      792
 Leu Ser Asn Ser Ile Leu Ser Leu Gln Pro Glu Pro Glu Ile Pro Pro
         210                 215                 220

 gaa ctg cct cca cca aga cca cat gtc cga tgc tgt tga tttcctactt       841
 Glu Leu Pro Pro Pro Arg Pro His Val Arg Cys Cys 
     225                 230                 235

 tggagacaaa gtggaaatga ttcctggaaa ggggaaaaaa cgttctattc tgcactacaa    901

 tcattttgac aatttccttt cgcactttgt aatccaagtc agagctatac actaacttgt    961

 aaatatgcat atatgcaatc ctgggtaagt tttggttata agttacctat ttccctccaa   1021

 attattatat ttcattcatt accccagtgt ctagtgtaca tacactggga aacctagtac   1081

 ttctaatatg aagaatggga gaaatgaaag gtataatgtt tcttgaaata aataatataa   1141

 ttgtccttat taattatatt atgaggacag aagatattct gataagagag aacgtggtgc   1201

 tttgcttacc gttttaaaga aaatttgtaa aactaaagac tttttgaaaa aaagctatct   1261

 taagtgcttt ttctttattt acaagacatt tcccccagtg gtagcatctg aagtattgga   1321

 gtgtttctgc cacgaagcaa agctccattc atggccgtca tggaaggtta tttattaatg   1381

 ttacataatg gtagaatatt actagttaga gggttggatt tgacttggtc ctaaggccac   1441

 agaatctctc tcatggcttc ctaagggatg tacctttatg cttttaagaa ctacaaagat   1501

 tcaataaaga aagaaatgtt tttgaaacta tagaaaaaga ttttaaaaca cgctgctgtc   1561

 ctaaacaaat cctgtttaaa ggaattttaa agagatgcat tttactatat caaagaacat   1621

 acgtgtattt gcctaaacac tctgtacctt tgtaatgata aaacttcccc cttctttacg   1681

 gtgaagctta ttctgattaa gcctagactg tgttcttttt tttttttttt gggcgggaaa   1741

 aaaaattgga aacctttatt ttgggaatat tttaaataaa ccgcccctgt tttgtaag     1799




      <210> 35
      <211> 1059
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (227)..(889)

      <400> 35
 cggtccgaac ctcccgggtc gacgatttcg tctttgcgag agtagcgcgg gagctgagaa     60

 gttgcagggt tgagttggtc ccggcaagtc cttgagcagt ttgttcctct gtcttcccgc    120

 ttcctggtgc cccgactgcg tccccacgaa cgccccgtcc ttaccgccgg ctgctgtgga    180

 gtgcctcgct gtctcccagg tccccgagtt cctggtttca gagaag   atg acc gaa     235
                                                      Met Thr Glu
                                                        1

 gaa gtg gat ttc ctg gga cag gac tct gat ggg ggt agt gag gaa gtg      283
 Glu Val Asp Phe Leu Gly Gln Asp Ser Asp Gly Gly Ser Glu Glu Val
       5                  10                  15

 gtc cta act cct gca gag ctc att gaa aga ttg gag cag gcc tgg atg      331
 Val Leu Thr Pro Ala Glu Leu Ile Glu Arg Leu Glu Gln Ala Trp Met
  20                  25                  30                  35

 aat gaa aag ttt gcc cct gag ctg ctg gag agc aag cct gag att gta      379
 Asn Glu Lys Phe Ala Pro Glu Leu Leu Glu Ser Lys Pro Glu Ile Val
                  40                  45                  50

 gaa tgt gtc atg gaa cag ctg gag cac atg gaa gaa aat ctc agg aga      427
 Glu Cys Val Met Glu Gln Leu Glu His Met Glu Glu Asn Leu Arg Arg
              55                  60                  65

 gcc aaa agg gag gac ctg aag gtc agc atc cac caa atg gag atg gag      475
 Ala Lys Arg Glu Asp Leu Lys Val Ser Ile His Gln Met Glu Met Glu
          70                  75                  80

 agg atc cgc tac gtc ctc agc agc tac ttg cgg tgt cgc ctc atg aag      523
 Arg Ile Arg Tyr Val Leu Ser Ser Tyr Leu Arg Cys Arg Leu Met Lys
      85                  90                  95

 ata gag aag ttt ttc cct cat gtc ctt gag aag gaa aaa aca cgt cct      571
 Ile Glu Lys Phe Phe Pro His Val Leu Glu Lys Glu Lys Thr Arg Pro
 100                 105                 110                 115

 gag ggg gag cct tcc agc ctc tcg ccg gaa gag ttg gcc ttt gcc aga      619
 Glu Gly Glu Pro Ser Ser Leu Ser Pro Glu Glu Leu Ala Phe Ala Arg
                 120                 125                 130

 gag ttc atg gcg aac aca gag tcc tat ctg aaa aat gtc gcc ttg aag      667
 Glu Phe Met Ala Asn Thr Glu Ser Tyr Leu Lys Asn Val Ala Leu Lys
             135                 140                 145

 cac atg ccc cct aac tta cag aag gtg gac ctc ttt cgg gca gtt ccc      715
 His Met Pro Pro Asn Leu Gln Lys Val Asp Leu Phe Arg Ala Val Pro
         150                 155                 160

 aaa cca gat cta gat tct tac gtg ttt ctg aga gtg aga gaa cga caa      763
 Lys Pro Asp Leu Asp Ser Tyr Val Phe Leu Arg Val Arg Glu Arg Gln
     165                 170                 175

 gaa aac ata ctg gta gaa cca gac aca gat gag cag agg gac tac gtg      811
 Glu Asn Ile Leu Val Glu Pro Asp Thr Asp Glu Gln Arg Asp Tyr Val
 180                 185                 190                 195

 att gac ctg gag aag ggc tca cag cac ttg atc cga tac aaa cat gga      859
 Ile Asp Leu Glu Lys Gly Ser Gln His Leu Ile Arg Tyr Lys His Gly
                 200                 205                 210

 ctc tgc tgc tct gga gct gtc cgc tat taa a caggctaacg cagctgggac      910
 Leu Cys Cys Ser Gly Ala Val Arg Tyr 
             215                 220

 aagcgggccg cttggagcga ggggggtcac gagggggtca acacgcctgg ggccccttca    970

 aaaacaggcg ggggggggcc acccccggcg caaaaacgaa gggggcgccc ccgcggggca   1030

 aaaaagcccc cgcctgacga atagtgaca                                     1059




      <210> 36
      <211> 1761
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (607)..(1707)

      <400> 36
 gcagagggct ccggcacacg gaaggtagga gctcggagcc ctaagggtcg gtccaagtgt     60

 ctgcgagaag cccgcagcgc ccaggaccgc gtggagcgct cggggcgcgc caagccgcac    120

 ttagccaaaa gagaaacgct gacgggccgt aggcgggttg gctgggacgc ggaatacgcg    180

 cggccccgga gcgcctttcg ttttaaggag ccttacttct ggaaagggac agggaactgt    240

 caatcagcga gggagggagc gcaccggcgc tgggtgatgt cagcggatca gctgctcgat    300

 aacaaagaga gggtattaca ggagaaagtt gcagcagcgg cagcggccaa ggcggcacac    360

 cggagcctcc gaggcgaggg gcaagtgggc gaagggaggg gggacgacgg ctgctgccgc    420

 agcagctgaa ggccaaggaa ttgaaagggc tgtaggggga ggcagtgcga gccagccccg    480

 actgctcctc ctcttcctcc tcctcctcca aactcgcgag ccccagagct cgctcagccg    540

 ccgggagcac ccagagggac gggaggcagc cgcgcagccc cgagctgggc agtgtcccca    600

 gccgcc   atg gat agc gac gac gag atg gtg gag gag gcg gtg gaa ggg     648
          Met Asp Ser Asp Asp Glu Met Val Glu Glu Ala Val Glu Gly
            1               5                  10

 cac ctg gac gat gac gga tta ccg cac ggg ttc tgc aca gtc acc tac      696
 His Leu Asp Asp Asp Gly Leu Pro His Gly Phe Cys Thr Val Thr Tyr
  15                  20                  25                  30

 tcc tcc aca gac aga ttt gag ggg aac ttt gtt cac gga gaa aag aac      744
 Ser Ser Thr Asp Arg Phe Glu Gly Asn Phe Val His Gly Glu Lys Asn
                  35                  40                  45

 gga cgg ggg aag ttc ttc ttc ttt gat ggc agc acc ctg gag ggg tat      792
 Gly Arg Gly Lys Phe Phe Phe Phe Asp Gly Ser Thr Leu Glu Gly Tyr
              50                  55                  60

 tat gtg gat gat gcc ttg cag ggc cag gga gtt tac act tac gaa gat      840
 Tyr Val Asp Asp Ala Leu Gln Gly Gln Gly Val Tyr Thr Tyr Glu Asp
          65                  70                  75

 ggg gga gtt ctc cag ggc acg tat gta gac gga gag ctg aac ggt cca      888
 Gly Gly Val Leu Gln Gly Thr Tyr Val Asp Gly Glu Leu Asn Gly Pro
      80                  85                  90

 gcc cag gaa tat gac aca gat ggg aga ctg atc ttc aag ggg cag tat      936
 Ala Gln Glu Tyr Asp Thr Asp Gly Arg Leu Ile Phe Lys Gly Gln Tyr
  95                 100                 105                 110

 aaa gat aac att cgt cat gga gtg tgc tgg ata tat tac cca gat gga      984
 Lys Asp Asn Ile Arg His Gly Val Cys Trp Ile Tyr Tyr Pro Asp Gly
                 115                 120                 125

 gga agc ctt gta gga gaa gta aat gaa gat ggg gag atg act gga gag     1032
 Gly Ser Leu Val Gly Glu Val Asn Glu Asp Gly Glu Met Thr Gly Glu
             130                 135                 140

 aag ata gcc tat gtg tac cct gat gag agg acc gca ctt tat ggg aaa     1080
 Lys Ile Ala Tyr Val Tyr Pro Asp Glu Arg Thr Ala Leu Tyr Gly Lys
         145                 150                 155

 ttt att gat gga gag atg ata gaa ggc aaa ctg gct acc ctt atg tcc     1128
 Phe Ile Asp Gly Glu Met Ile Glu Gly Lys Leu Ala Thr Leu Met Ser
     160                 165                 170

 act gaa gaa ggg agg cct cac ttt gaa ctg atg cct gga aat tca gtg     1176
 Thr Glu Glu Gly Arg Pro His Phe Glu Leu Met Pro Gly Asn Ser Val
 175                 180                 185                 190

 tac cac ttt gat aag tcg act tca tct tgc att tct acc aat gct ctt     1224
 Tyr His Phe Asp Lys Ser Thr Ser Ser Cys Ile Ser Thr Asn Ala Leu
                 195                 200                 205

 ctt cca gat cct tat gaa tca gaa agg gtt tat gtt gct gaa tct ctt     1272
 Leu Pro Asp Pro Tyr Glu Ser Glu Arg Val Tyr Val Ala Glu Ser Leu
             210                 215                 220

 att tcc agt gct gga gaa gga ctt ttt tca aag gta gct gtg gga cct     1320
 Ile Ser Ser Ala Gly Glu Gly Leu Phe Ser Lys Val Ala Val Gly Pro
         225                 230                 235

 aat act gtt atg tct ttt tat aat gga gtt cga att aca cac caa gag     1368
 Asn Thr Val Met Ser Phe Tyr Asn Gly Val Arg Ile Thr His Gln Glu
     240                 245                 250

 gtt gac agc agg gac tgg gcc ctt aat ggg aac acc ctc tcc ctt gat     1416
 Val Asp Ser Arg Asp Trp Ala Leu Asn Gly Asn Thr Leu Ser Leu Asp
 255                 260                 265                 270

 gaa gaa acg gtc att gat gtg cct gag ccc tat aac cac gta tcc aag     1464
 Glu Glu Thr Val Ile Asp Val Pro Glu Pro Tyr Asn His Val Ser Lys
                 275                 280                 285

 tac tgt gcc tcc ttg gga cac aag gca aat cac tcc ttc act cca aac     1512
 Tyr Cys Ala Ser Leu Gly His Lys Ala Asn His Ser Phe Thr Pro Asn
             290                 295                 300

 tgc atc tac gat atg ttt gtc cac ccc cgt ttt ggg ccc atc aaa tgc     1560
 Cys Ile Tyr Asp Met Phe Val His Pro Arg Phe Gly Pro Ile Lys Cys
         305                 310                 315

 atc cgc acc ctg aga gca gtg gag gcc gat gaa gag ctc acc gtt gcc     1608
 Ile Arg Thr Leu Arg Ala Val Glu Ala Asp Glu Glu Leu Thr Val Ala
     320                 325                 330

 tat ggc tat gac cac agc ccc ccc ggg aag agt ggg cct gaa gcc cct     1656
 Tyr Gly Tyr Asp His Ser Pro Pro Gly Lys Ser Gly Pro Glu Ala Pro
 335                 340                 345                 350

 gag tgg tac cag gtg gag ctg aag gcc ttc cag gcc acc cag caa aag     1704
 Glu Trp Tyr Gln Val Glu Leu Lys Ala Phe Gln Ala Thr Gln Gln Lys
                 355                 360                 365

 tga aagg cctggctttg gggttcagag acctggaata gatacttgga tctatgcact     1761
 






      <210> 37
      <211> 1379
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (396)..(1379)

      <400> 37
 cgaaggcttc ttcctactct cctgcacctt ctcctccttg agtcaaggcc tccggatcca     60

 catggatagc tgagatcttt tcttggagaa agacgctttc ctctttactc cagtccctca    120

 cttccccacc tgattttcct cctcttctgc tggtcctgtc tttttctact gcctctttat    180

 tcaatttctt gcttgtgtgc ccctttggga ctctcttgta cactttcctc catctccact    240

 atctcaggat ctgtgtgtgt gctgccttcc tcctgtgtgc tttctgtccc cccatctctg    300

 tcttgtcttt cccacttcta ttgccaaagg gagagatcct ctccgggctg ttccctggcc    360

 tgtctgctcc tccgggctct gtcccagcag cgaca   atg agc tcc aca ctc cac     413
                                          Met Ser Ser Thr Leu His
                                            1               5

 tcg gtt ttc ttc acc ctg aag gtc agc atc ctg ctg ggg tcc ctg ctg      461
 Ser Val Phe Phe Thr Leu Lys Val Ser Ile Leu Leu Gly Ser Leu Leu
              10                  15                  20

 ggg ctc tgc ctg ggc ctt gag ttc atg ggc ctc ccc aac cag tgg gcc      509
 Gly Leu Cys Leu Gly Leu Glu Phe Met Gly Leu Pro Asn Gln Trp Ala
          25                  30                  35

 cgc tac ctc cgc tgg gat gcc agc aca cgc agt gac ctg agt ttc cag      557
 Arg Tyr Leu Arg Trp Asp Ala Ser Thr Arg Ser Asp Leu Ser Phe Gln
      40                  45                  50

 ttc aag acc aac gtc tct acg ggg ctg ctc ctc tac ctg gat gat ggc      605
 Phe Lys Thr Asn Val Ser Thr Gly Leu Leu Leu Tyr Leu Asp Asp Gly
  55                  60                  65                  70

 ggc gtc tgc gac ttc cta tgc ctc tcc ctg gtg gat ggc cgc gtt cag      653
 Gly Val Cys Asp Phe Leu Cys Leu Ser Leu Val Asp Gly Arg Val Gln
                  75                  80                  85

 ctc cgc ttc agc atg gac tgt gcc gag act gcc gtg ctg tcc aac aag      701
 Leu Arg Phe Ser Met Asp Cys Ala Glu Thr Ala Val Leu Ser Asn Lys
              90                  95                 100

 cag gtg aat gac agc agc tgg cac ttc ctc atg gtg agc cgt gac cgc      749
 Gln Val Asn Asp Ser Ser Trp His Phe Leu Met Val Ser Arg Asp Arg
         105                 110                 115

 ctg cgc acg gtg ctg atg ctt gat ggc gag ggc cag tct ggg gag ctg      797
 Leu Arg Thr Val Leu Met Leu Asp Gly Glu Gly Gln Ser Gly Glu Leu
     120                 125                 130

 cag ccc cag cgg ccc tac atg gat gtg gtc agt gac ttg ttc ctt ggt      845
 Gln Pro Gln Arg Pro Tyr Met Asp Val Val Ser Asp Leu Phe Leu Gly
 135                 140                 145                 150

 gga gtc cct act gac ata cga cct tct gcc ctg acc ctt gat gga gtt      893
 Gly Val Pro Thr Asp Ile Arg Pro Ser Ala Leu Thr Leu Asp Gly Val
                 155                 160                 165

 cag gcc atg ccc ggc ttc aag ggg tta att ctg gat ctc aag tat gga      941
 Gln Ala Met Pro Gly Phe Lys Gly Leu Ile Leu Asp Leu Lys Tyr Gly
             170                 175                 180

 aac tcg gag cct cgg ctt ctg ggg agc cgg ggt gtc cag atg gat gcc      989
 Asn Ser Glu Pro Arg Leu Leu Gly Ser Arg Gly Val Gln Met Asp Ala
         185                 190                 195

 gag gga ccc tgt ggt gag cgt ccc tgt gaa aat ggt ggg atc tgc ttt     1037
 Glu Gly Pro Cys Gly Glu Arg Pro Cys Glu Asn Gly Gly Ile Cys Phe
     200                 205                 210

 ctc ctg gac ggc cac ccc acc tgt gac tgt tct acc act ggc tat ggt     1085
 Leu Leu Asp Gly His Pro Thr Cys Asp Cys Ser Thr Thr Gly Tyr Gly
 215                 220                 225                 230

 ggc aag ctc tgc tca gaa gag cat ggg gct gct gac aat ggt tat gac     1133
 Gly Lys Leu Cys Ser Glu Glu His Gly Ala Ala Asp Asn Gly Tyr Asp
                 235                 240                 245

 tgc ggg atg gga ttc agg gct ctg ccg gca aac gtg tgg tgt tct ggc     1181
 Cys Gly Met Gly Phe Arg Ala Leu Pro Ala Asn Val Trp Cys Ser Gly
             250                 255                 260

 ctc agc agc cac cca gtg agg cag cct caa aac tct ggt ttt agt gaa     1229
 Leu Ser Ser His Pro Val Arg Gln Pro Gln Asn Ser Gly Phe Ser Glu
         265                 270                 275

 gtg act ggg att gga ccc aag gct ccg gag gta gtt gga gca cag gtg     1277
 Val Thr Gly Ile Gly Pro Lys Ala Pro Glu Val Val Gly Ala Gln Val
     280                 285                 290

 cac cac acc gga gct tcg ctg gac agg atg acc tct tca aac tta cct     1325
 His His Thr Gly Ala Ser Leu Asp Arg Met Thr Ser Ser Asn Leu Pro
 295                 300                 305                 310

 ttg gtt tcc cag gta cca ggc aat gcc cat tac ctc act cag ggt tgg     1373
 Leu Val Ser Gln Val Pro Gly Asn Ala His Tyr Leu Thr Gln Gly Trp
                 315                 320                 325

 tgg tga                                                             1379
 Trp 






      <210> 38
      <211> 2575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(2575)

      <400> 38
 tttcgtccgg atccgagcgc aaagtctggg cctccccagg aag  atg tgg ggg agg      55
                                                  Met Trp Gly Arg
                                                    1

 ctc tgg ccc ctc ctc ctc agc atc ctc aca gca act gca gtc cca gga      103
 Leu Trp Pro Leu Leu Leu Ser Ile Leu Thr Ala Thr Ala Val Pro Gly
   5                  10                  15                  20

 ccc cca ctg cgg aga ccg tct aga gaa cta gat gcc acc cct cgg atg      151
 Pro Pro Leu Arg Arg Pro Ser Arg Glu Leu Asp Ala Thr Pro Arg Met
                  25                  30                  35

 acc ata ccc tat gaa gag ctc tct ggg acc cgg cac ttc aag ggc caa      199
 Thr Ile Pro Tyr Glu Glu Leu Ser Gly Thr Arg His Phe Lys Gly Gln
              40                  45                  50

 gcc cag aac tac tca aca ctg ctg ctg gag gag gcc tca gca agg ctg      247
 Ala Gln Asn Tyr Ser Thr Leu Leu Leu Glu Glu Ala Ser Ala Arg Leu
          55                  60                  65

 ctg gtg gga gcc cga ggt gcc ctg ttc tct ctc agt gcc aac gac ata      295
 Leu Val Gly Ala Arg Gly Ala Leu Phe Ser Leu Ser Ala Asn Asp Ile
      70                  75                  80

 gga gat ggg gct cac aaa gag atc cac tgg gaa gcc tcc cca gag atg      343
 Gly Asp Gly Ala His Lys Glu Ile His Trp Glu Ala Ser Pro Glu Met
  85                  90                  95                 100

 caa agc aaa tgt cat caa aaa ggg aaa aac aac cag acg gag tgc ttt      391
 Gln Ser Lys Cys His Gln Lys Gly Lys Asn Asn Gln Thr Glu Cys Phe
                 105                 110                 115

 aac cat gtg cgg ttc ctg cag cgg ctc aat tct acc cac ctc tat gca      439
 Asn His Val Arg Phe Leu Gln Arg Leu Asn Ser Thr His Leu Tyr Ala
             120                 125                 130

 tgt ggg act cac gcc ttc cag ccc ctc tgt gca gcc att gat gct gag      487
 Cys Gly Thr His Ala Phe Gln Pro Leu Cys Ala Ala Ile Asp Ala Glu
         135                 140                 145

 gcc ttc acc ttg cca acc agc ttc gag gag ggg aag gag aag tgt cct      535
 Ala Phe Thr Leu Pro Thr Ser Phe Glu Glu Gly Lys Glu Lys Cys Pro
     150                 155                 160

 tat gac cca gcc cgt ggc ttc aca ggc ctc atc att gat gga ggc ctc      583
 Tyr Asp Pro Ala Arg Gly Phe Thr Gly Leu Ile Ile Asp Gly Gly Leu
 165                 170                 175                 180

 tac aca gcc act agg tat gaa ttc cgg agc att cct gac atc cgc cgg      631
 Tyr Thr Ala Thr Arg Tyr Glu Phe Arg Ser Ile Pro Asp Ile Arg Arg
                 185                 190                 195

 agc cgc cac cca cac tcc ctg aga act gag gag aca cca atg cat tgg      679
 Ser Arg His Pro His Ser Leu Arg Thr Glu Glu Thr Pro Met His Trp
             200                 205                 210

 ctc aat gat gcg gag ttt gtg ttc tcc gtc ctc gtg cgg gag agc aag      727
 Leu Asn Asp Ala Glu Phe Val Phe Ser Val Leu Val Arg Glu Ser Lys
         215                 220                 225

 gcc agt gca gtg ggt gat gat gac aag gtg tac tac ttc ttc acg gag      775
 Ala Ser Ala Val Gly Asp Asp Asp Lys Val Tyr Tyr Phe Phe Thr Glu
     230                 235                 240

 cgt gcc act gag gag ggc tct ggc agc ttc act cag agc cgc agc agt      823
 Arg Ala Thr Glu Glu Gly Ser Gly Ser Phe Thr Gln Ser Arg Ser Ser
 245                 250                 255                 260

 cac cgt gtg gcc cgt gtg gct cgt gtc tgc aag gga gac ctg gga ggg      871
 His Arg Val Ala Arg Val Ala Arg Val Cys Lys Gly Asp Leu Gly Gly
                 265                 270                 275

 aag aag atc ctg cag aag aag tgg act tcc ttc ctg aaa gcc cgt ctc      919
 Lys Lys Ile Leu Gln Lys Lys Trp Thr Ser Phe Leu Lys Ala Arg Leu
             280                 285                 290

 atc tgc cac att cca ctg tat gag aca ctg cgt ggg gtc tgc agc ctg      967
 Ile Cys His Ile Pro Leu Tyr Glu Thr Leu Arg Gly Val Cys Ser Leu
         295                 300                 305

 gat gct gaa acc tca agc cgt aca cac ttc tat gca gcc ttc acg ctg     1015
 Asp Ala Glu Thr Ser Ser Arg Thr His Phe Tyr Ala Ala Phe Thr Leu
     310                 315                 320

 agc aca cag tgg aag acc ctg gag gcc tca gcc atc tgc cgc tat gac     1063
 Ser Thr Gln Trp Lys Thr Leu Glu Ala Ser Ala Ile Cys Arg Tyr Asp
 325                 330                 335                 340

 ctg gca gag atc cag gct gtc ttt gca gga ccc tat atg gaa tac cag     1111
 Leu Ala Glu Ile Gln Ala Val Phe Ala Gly Pro Tyr Met Glu Tyr Gln
                 345                 350                 355

 gat ggt tcc cgg cgc tgg ggt cgc tat gag ggt ggg gtg cct gag ccc     1159
 Asp Gly Ser Arg Arg Trp Gly Arg Tyr Glu Gly Gly Val Pro Glu Pro
             360                 365                 370

 cgg cct ggc tcg tgt atc aca gat tca ttg cgc agc caa ggc tac aat     1207
 Arg Pro Gly Ser Cys Ile Thr Asp Ser Leu Arg Ser Gln Gly Tyr Asn
         375                 380                 385

 tca tcc caa gac ttg cca tcc ctg gtc ctg gac ttt gta aag ttg cac     1255
 Ser Ser Gln Asp Leu Pro Ser Leu Val Leu Asp Phe Val Lys Leu His
     390                 395                 400

 cca ctg atg gct cgg ccc gtt gtg ccc aca cgt gga cgg ccc ctg ctg     1303
 Pro Leu Met Ala Arg Pro Val Val Pro Thr Arg Gly Arg Pro Leu Leu
 405                 410                 415                 420

 ctc aag cgc aac ata cgc tac aca cac ctt aca ggg aca cct gtc acc     1351
 Leu Lys Arg Asn Ile Arg Tyr Thr His Leu Thr Gly Thr Pro Val Thr
                 425                 430                 435

 acg cct gct gga cct acc tat gac ctg ctc ttt ctg ggc aca gct gat     1399
 Thr Pro Ala Gly Pro Thr Tyr Asp Leu Leu Phe Leu Gly Thr Ala Asp
             440                 445                 450

 ggc tgg atc cac aag gcc gta gtc ctg ggc tct ggg atg cac att att     1447
 Gly Trp Ile His Lys Ala Val Val Leu Gly Ser Gly Met His Ile Ile
         455                 460                 465

 gaa gag aca caa gtg ttc agg gag tcc cag tct gtg gaa aat cta gtc     1495
 Glu Glu Thr Gln Val Phe Arg Glu Ser Gln Ser Val Glu Asn Leu Val
     470                 475                 480

 atc tct cta ttg cag cac agc ctc tat gtg ggg gct cct agc gga gtc     1543
 Ile Ser Leu Leu Gln His Ser Leu Tyr Val Gly Ala Pro Ser Gly Val
 485                 490                 495                 500

 atc cag cta cca ctc tcc agc tgc tcc cgc tac cga tcc tgc tat gac     1591
 Ile Gln Leu Pro Leu Ser Ser Cys Ser Arg Tyr Arg Ser Cys Tyr Asp
                 505                 510                 515

 tgc atc ttg gcc cga gac ccc tac tgt ggc tgg gac cct ggc acc cat     1639
 Cys Ile Leu Ala Arg Asp Pro Tyr Cys Gly Trp Asp Pro Gly Thr His
             520                 525                 530

 gcc tgc gca gca gcc acc acc ata gcc aac agg tcc cag gga agc agg     1687
 Ala Cys Ala Ala Ala Thr Thr Ile Ala Asn Arg Ser Gln Gly Ser Arg
         535                 540                 545

 aca gca ctg ata cag gac ata gag aga gga aat cga ggc tgt gag agc     1735
 Thr Ala Leu Ile Gln Asp Ile Glu Arg Gly Asn Arg Gly Cys Glu Ser
     550                 555                 560

 agc agg gat aca ggg cca cca cca cca ctg aag acc cgc tct gtg ctc     1783
 Ser Arg Asp Thr Gly Pro Pro Pro Pro Leu Lys Thr Arg Ser Val Leu
 565                 570                 575                 580

 cgg ggt gat gat gtc ctc ctg ccc tgt gac cag cca tcc aac ctg gcc     1831
 Arg Gly Asp Asp Val Leu Leu Pro Cys Asp Gln Pro Ser Asn Leu Ala
                 585                 590                 595

 cgg gcc ttg tgg cta ctc aat ggg agc atg ggc ctg agc gat ggg cag     1879
 Arg Ala Leu Trp Leu Leu Asn Gly Ser Met Gly Leu Ser Asp Gly Gln
             600                 605                 610

 ggt ggc tac cgt gtg ggc gtg gac ggg ctg ctg gtt aca gat gca cag     1927
 Gly Gly Tyr Arg Val Gly Val Asp Gly Leu Leu Val Thr Asp Ala Gln
         615                 620                 625

 cct gag cac agt ggc aac tat ggc tgc tat gcc gag gaa aat ggc ctc     1975
 Pro Glu His Ser Gly Asn Tyr Gly Cys Tyr Ala Glu Glu Asn Gly Leu
     630                 635                 640

 cgc acc ctg ctg gcc tcc tat agt ctc aca gtc cgg cca gcc act cct     2023
 Arg Thr Leu Leu Ala Ser Tyr Ser Leu Thr Val Arg Pro Ala Thr Pro
 645                 650                 655                 660

 gcc cca gct cca aaa gcc cct gcc aca cct ggg gca cag ctg gca cct     2071
 Ala Pro Ala Pro Lys Ala Pro Ala Thr Pro Gly Ala Gln Leu Ala Pro
                 665                 670                 675

 gat gtg aga ctg ctc tat gtg cta gcc att gcc gcg ctt ggt ggc ctc     2119
 Asp Val Arg Leu Leu Tyr Val Leu Ala Ile Ala Ala Leu Gly Gly Leu
             680                 685                 690

 tgc ctc atc ctg gcc tcc tcc ctc ctc tat gtg gcc tgt ctg cgg gaa     2167
 Cys Leu Ile Leu Ala Ser Ser Leu Leu Tyr Val Ala Cys Leu Arg Glu
         695                 700                 705

 ggc aga cga ggg cgc cga cgg aaa tac tca ctg ggt cgg gcc agc cgg     2215
 Gly Arg Arg Gly Arg Arg Arg Lys Tyr Ser Leu Gly Arg Ala Ser Arg
     710                 715                 720

 gca gga gga tct gcg gtg caa ctg cag aca gtc tca ggc cag tgt cct     2263
 Ala Gly Gly Ser Ala Val Gln Leu Gln Thr Val Ser Gly Gln Cys Pro
 725                 730                 735                 740

 gga gag gaa gat gag ggt gat gat gag ggg gct ggg ggc ctg gag ggc     2311
 Gly Glu Glu Asp Glu Gly Asp Asp Glu Gly Ala Gly Gly Leu Glu Gly
                 745                 750                 755

 agc tgt ctc cag atc atc cct ggg gag gga gcc cca gcc cca cca ccc     2359
 Ser Cys Leu Gln Ile Ile Pro Gly Glu Gly Ala Pro Ala Pro Pro Pro
             760                 765                 770

 cca ccg ccc cca ccg cca ccg gct gag ctg acc aat ggc ttg gtg gca     2407
 Pro Pro Pro Pro Pro Pro Pro Ala Glu Leu Thr Asn Gly Leu Val Ala
         775                 780                 785

 ctg ccc agc cgg ctg cgg agg atg aat ggc aat agc tat gtg ctt ctg     2455
 Leu Pro Ser Arg Leu Arg Arg Met Asn Gly Asn Ser Tyr Val Leu Leu
     790                 795                 800

 agg cag agc aac aat gga gta cca gca ggg ccc tgc tcc ttc gcc gag     2503
 Arg Gln Ser Asn Asn Gly Val Pro Ala Gly Pro Cys Ser Phe Ala Glu
 805                 810                 815                 820

 gaa ctc agc cgc atc ctg gaa aaa agg aag cac acg cag ctc gtg gag     2551
 Glu Leu Ser Arg Ile Leu Glu Lys Arg Lys His Thr Gln Leu Val Glu
                 825                 830                 835

 cag cta gat gag agc tct gtc tga                                     2575
 Gln Leu Asp Glu Ser Ser Val 
             840





      <210> 39
      <211> 715
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (514)..(687)

      <400> 39
 gacaggtata ctgttagatg agacgttatt atgtctgtgg tattgagctg tacagggggt     60

 ttgctgtatt atctcaaact acctgtagtg tatttgtagg gatgggtgag agtaactgtg    120

 cttggaatag aaaagccctg ctgcatcgag acacaatgct ggcagctgcg gcagtgtaca    180

 gaggtaaggg gcgaccactc tttcacccgc ctcaccaagg cacttgtgct gtatcatgtt    240

 gattcccttc acgttgccaa tgcattttcc attcctgtta aggctccctc agacttcttg    300

 tccttcctct caaaacacag atcctgtagc tttttccaga cagcctttac tatttcctta    360

 ccctcagtat taagaatttt tcatgtaaga tgttctcaga atcttacaag tatccttgta    420

 cccatttctt tttgaagaac atgaccttta ttgagcagaa attttttcct acttgcattt    480

 tttcagactt taaccattat tgtcttttta gaa atg tac aga aat gaa gat ggt     534
                                      Met Tyr Arg Asn Glu Asp Gly
                                        1               5

 tca gta cct gct aca tac cag atc tat tac atg ata gga tgg aaa tat      582
 Ser Val Pro Ala Thr Tyr Gln Ile Tyr Tyr Met Ile Gly Trp Lys Tyr
          10                  15                  20

 cat gag tca cag gca aga cca gct gaa aga ggt tcc gca act gtg tca      630
 His Glu Ser Gln Ala Arg Pro Ala Glu Arg Gly Ser Ala Thr Val Ser
      25                  30                  35

 ttt gga gag cta gga aaa ata aac aac ctt atg cca ccg ggg aaa aaa      678
 Phe Gly Glu Leu Gly Lys Ile Asn Asn Leu Met Pro Pro Gly Lys Lys
  40                  45                  50                  55

 tca caa taa atatttattc agtgttaaaa aaaaaaaa                           715
 Ser Gln 






      <210> 40
      <211> 2056
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (159)..(1730)

      <400> 40
 gcaagccaaa cccacgaatt aagctcttga ctgcccatcc acaagcccca gtgccaagca     60

 catataaagg cacctgccag tcctcactac aaccagcaga accttttggg attttgcctt    120

 cctccctcct gcatctgagc tttgtctcca ccagcaac    atg agc cgc caa ttc     173
                                              Met Ser Arg Gln Phe
                                                1               5

 acc tgc aag tcg gga gct gcc gcc aag ggg ggc ttc agt ggc tgc tca      221
 Thr Cys Lys Ser Gly Ala Ala Ala Lys Gly Gly Phe Ser Gly Cys Ser
                  10                  15                  20

 gct gtg ctc tca ggg ggc agc tca tcc tcc ttc cgg gca ggg agc aaa      269
 Ala Val Leu Ser Gly Gly Ser Ser Ser Ser Phe Arg Ala Gly Ser Lys
              25                  30                  35

 ggg ctc agt ggg ggc ttt ggc agc cgg agc ctc tac agc ctg ggg ggt      317
 Gly Leu Ser Gly Gly Phe Gly Ser Arg Ser Leu Tyr Ser Leu Gly Gly
          40                  45                  50

 gtc cgg agc ctc aat gtg gcc agt ggc agc ggg aag agt gga ggc tat      365
 Val Arg Ser Leu Asn Val Ala Ser Gly Ser Gly Lys Ser Gly Gly Tyr
      55                  60                  65

 gga ttt ggc cgg ggc cgg gcc agt ggc ttt gct gga agc atg ttt ggc      413
 Gly Phe Gly Arg Gly Arg Ala Ser Gly Phe Ala Gly Ser Met Phe Gly
  70                  75                  80                  85

 agt gtg gcc ctg ggg cct gtg tgc cca act gta tgc cca cct gga ggc      461
 Ser Val Ala Leu Gly Pro Val Cys Pro Thr Val Cys Pro Pro Gly Gly
                  90                  95                 100

 atc cac cag gtt acc gtc aat gag agc ctc ctg gcc ccc ctc aac gtg      509
 Ile His Gln Val Thr Val Asn Glu Ser Leu Leu Ala Pro Leu Asn Val
             105                 110                 115

 gag ctg gac ccc gag atc cag aaa gtg cgt gcc cag gag cga gag cag      557
 Glu Leu Asp Pro Glu Ile Gln Lys Val Arg Ala Gln Glu Arg Glu Gln
         120                 125                 130

 atc aag gct ctg aac aac aag ttc gcc tcc ttc atc gac aag gtg cgg      605
 Ile Lys Ala Leu Asn Asn Lys Phe Ala Ser Phe Ile Asp Lys Val Arg
     135                 140                 145

 ttc ctg gag cag cag aac cag gta ctg gag acc aag tgg gag ctg ctg      653
 Phe Leu Glu Gln Gln Asn Gln Val Leu Glu Thr Lys Trp Glu Leu Leu
 150                 155                 160                 165

 cag cag ctg gac ctg aac aac tgc aag aac aac ctg gag ccc atc ctc      701
 Gln Gln Leu Asp Leu Asn Asn Cys Lys Asn Asn Leu Glu Pro Ile Leu
                 170                 175                 180

 gag ggc tac atc agc aac ctg cgg aag cag ctg gag acg ctg tct ggg      749
 Glu Gly Tyr Ile Ser Asn Leu Arg Lys Gln Leu Glu Thr Leu Ser Gly
             185                 190                 195

 gac agg gtg agg ctg gac tcg gag ctg agg aat gtg cgg gac gta gtg      797
 Asp Arg Val Arg Leu Asp Ser Glu Leu Arg Asn Val Arg Asp Val Val
         200                 205                 210

 gag gac tac aag aag agg tat gag gag gaa atc aac aag cgg aca gca      845
 Glu Asp Tyr Lys Lys Arg Tyr Glu Glu Glu Ile Asn Lys Arg Thr Ala
     215                 220                 225

 gca gag aac gag ttt gtg ctg ctc aag aag gat gtg gat gct gct tac      893
 Ala Glu Asn Glu Phe Val Leu Leu Lys Lys Asp Val Asp Ala Ala Tyr
 230                 235                 240                 245

 gcc aat aag gtg gaa ctg cag gcc aag gtg gaa tcc atg gac cag gag      941
 Ala Asn Lys Val Glu Leu Gln Ala Lys Val Glu Ser Met Asp Gln Glu
                 250                 255                 260

 atc aag ttc ttc agg tgt ctc ttt gaa gcc gag atc act cag atc cag      989
 Ile Lys Phe Phe Arg Cys Leu Phe Glu Ala Glu Ile Thr Gln Ile Gln
             265                 270                 275

 tcc cac atc agt gac atg tct gtc atc ctg tcc atg gac aac aac cgg     1037
 Ser His Ile Ser Asp Met Ser Val Ile Leu Ser Met Asp Asn Asn Arg
         280                 285                 290

 aac cta gac ctg gac agc atc att gac gaa gtc cgc acc cag tat gag     1085
 Asn Leu Asp Leu Asp Ser Ile Ile Asp Glu Val Arg Thr Gln Tyr Glu
     295                 300                 305

 gag att gcc ttg aag agt aag gcc gag gct gag gcc ctg tac cag acc     1133
 Glu Ile Ala Leu Lys Ser Lys Ala Glu Ala Glu Ala Leu Tyr Gln Thr
 310                 315                 320                 325

 aag ttc caa gag ctt cag ctg gca gct ggc agg cat ggg gac gac ctc     1181
 Lys Phe Gln Glu Leu Gln Leu Ala Ala Gly Arg His Gly Asp Asp Leu
                 330                 335                 340

 aaa aac acc aag aat gaa atc tcg gag ctc act cgg ctc atc cag aga     1229
 Lys Asn Thr Lys Asn Glu Ile Ser Glu Leu Thr Arg Leu Ile Gln Arg
             345                 350                 355

 atc cgc tca gag atc gag aac gtg aag aag cag gct tcc aac ctg gag     1277
 Ile Arg Ser Glu Ile Glu Asn Val Lys Lys Gln Ala Ser Asn Leu Glu
         360                 365                 370

 aca gcc atc gct gat gct gag cag cgg gga gac aac gcc ctg aag gat     1325
 Thr Ala Ile Ala Asp Ala Glu Gln Arg Gly Asp Asn Ala Leu Lys Asp
     375                 380                 385

 gcc cgg gcc aag ctg gac gag ctg gag ggc gcc ctg cac cag gcc aag     1373
 Ala Arg Ala Lys Leu Asp Glu Leu Glu Gly Ala Leu His Gln Ala Lys
 390                 395                 400                 405

 gag gag ctg gcg cgg atg ctg cgc gag tac cag gag ctc atg agc ctg     1421
 Glu Glu Leu Ala Arg Met Leu Arg Glu Tyr Gln Glu Leu Met Ser Leu
                 410                 415                 420

 aag ctg gcc ctg gac atg gag atc gcc acc tat cgc aag cta ctg gag     1469
 Lys Leu Ala Leu Asp Met Glu Ile Ala Thr Tyr Arg Lys Leu Leu Glu
             425                 430                 435

 agc gag gag tgc agg atg tca gga gaa ttt ccc tcc cct gtc agc atc     1517
 Ser Glu Glu Cys Arg Met Ser Gly Glu Phe Pro Ser Pro Val Ser Ile
         440                 445                 450

 tcc atc atc agc agc acc agt ggc ggc agt ggc tat ggc ttc cgg ccc     1565
 Ser Ile Ile Ser Ser Thr Ser Gly Gly Ser Gly Tyr Gly Phe Arg Pro
     455                 460                 465

 agc atg gtc agc ggt ggc tat gtg gcc aac agc agc aac tgc atc tct     1613
 Ser Met Val Ser Gly Gly Tyr Val Ala Asn Ser Ser Asn Cys Ile Ser
 470                 475                 480                 485

 gga gtg tgc agc gtg aga ggc ggg gag ggc agg agc cgg ggc agt gcc     1661
 Gly Val Cys Ser Val Arg Gly Gly Glu Gly Arg Ser Arg Gly Ser Ala
                 490                 495                 500

 aac gat tac aaa gac acc ctg ggg aag ggt tcc agc ctg agt gca ccc     1709
 Asn Asp Tyr Lys Asp Thr Leu Gly Lys Gly Ser Ser Leu Ser Ala Pro
             505                 510                 515

 tcc aag aaa acc agt cgg tag ag aagactgccc cggaccccgc ctcattccat     1762
 Ser Lys Lys Thr Ser Arg 
         520

 gacccggctc tggatcccac actgtacttc ccacagccca ctctcagctc catctccacc   1822

 ctgctggtcc tgctcccata cacctggcac tggccttggc cacccacttc tcccagcctg   1882

 tgtcttcctg atcctgggaa ggcctggatg accaagcttg gtgaaattcc tccctgtaca   1942

 caccctatta actccttggc tgtggtcccc cagctacacc accagcccag gtcctggctg   2002

 ccagctttcc tcctctgccc ggcctctagc gcagtcgcta actactctgc tgcg         2056




      <210> 41
      <211> 911
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (38)..(760)

      <400> 41
 cttggaaacc cacccagaac ctttaccctc tgacacc atg gtc agc tcc tgt tgt      55
                                          Met Val Ser Ser Cys Cys
                                            1               5

 ggt tcc gtc tgc tct gac cag ggc tgt ggc ctg gag acc tgc tgc cgc      103
 Gly Ser Val Cys Ser Asp Gln Gly Cys Gly Leu Glu Thr Cys Cys Arg
              10                  15                  20

 ccc agc tgc tgt cag acc acc tgc tgc agg acc acc tgc tgc cgc ccc      151
 Pro Ser Cys Cys Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro
          25                  30                  35

 agc tgc tgt gtg tcc agc tgc tgc aga ccc cag tgc tgc cag tct gtg      199
 Ser Cys Cys Val Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val
      40                  45                  50

 tgc tgc cag ccc acc tgc tgc cgt ccc agc tgc tgt ccc agc tgc tgt      247
 Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Pro Ser Cys Cys
  55                  60                  65                  70

 cag acc acc tgc tgc agg acc acc tgc tgc cgc cct agc tgc tgt gta      295
 Gln Thr Thr Cys Cys Arg Thr Thr Cys Cys Arg Pro Ser Cys Cys Val
                  75                  80                  85

 tcc agc tgc tgc aga ccc cag tgc tgc cag tct gtg tgc tgc cag ccc      343
 Ser Ser Cys Cys Arg Pro Gln Cys Cys Gln Ser Val Cys Cys Gln Pro
              90                  95                 100

 act tgc tgc cgt ccc agc tgc agc atc tcc agc tgc tgt cgc ccc agc      391
 Thr Cys Cys Arg Pro Ser Cys Ser Ile Ser Ser Cys Cys Arg Pro Ser
         105                 110                 115

 tgc tgt gtg tcc agc tgc tgc aag ccc cag tgc tgc cag tct gtg tgc      439
 Cys Cys Val Ser Ser Cys Cys Lys Pro Gln Cys Cys Gln Ser Val Cys
     120                 125                 130

 tgc cag ccc acc tgc tgc cac ccc agc tgc tgc atc tcc agc tgc tgt      487
 Cys Gln Pro Thr Cys Cys His Pro Ser Cys Cys Ile Ser Ser Cys Cys
 135                 140                 145                 150

 cgc ccc agc tgc tgt gtg tcc agg tgc tgc agg ccc cag tgc tgc cag      535
 Arg Pro Ser Cys Cys Val Ser Arg Cys Cys Arg Pro Gln Cys Cys Gln
                 155                 160                 165

 tct gtg tgc tgc cag cca acc tgc tgc cgt ccc agc tgc tgc atc tcc      583
 Ser Val Cys Cys Gln Pro Thr Cys Cys Arg Pro Ser Cys Cys Ile Ser
             170                 175                 180

 agc tgc tgc cgc ccc tct tgc tgt gaa tcc agc tgc tgc cgc cca tgc      631
 Ser Cys Cys Arg Pro Ser Cys Cys Glu Ser Ser Cys Cys Arg Pro Cys
         185                 190                 195

 tgc tgc cgc ccc tgc tgc tgc ctg cgt cca gtc tgt ggc cga gtc tcc      679
 Cys Cys Arg Pro Cys Cys Cys Leu Arg Pro Val Cys Gly Arg Val Ser
     200                 205                 210

 tgc cac acc act tgc tat cgc cca acc tgt gtc atc tcc acc tgt ccc      727
 Cys His Thr Thr Cys Tyr Arg Pro Thr Cys Val Ile Ser Thr Cys Pro
 215                 220                 225                 230

 cgc ccc ttg tgc tgt gcc tcc tct tgc tgc tga gcccactg ccctggctca      778
 Arg Pro Leu Cys Cys Ala Ser Ser Cys Cys 
                 235                 240

 cgtccccctt caccactggc ccacagatgt agacccttct actgtgctga ccattaggat    838

 acatgaagtg gggttgatgt cattcaatag gatggacctt atgcttccaa agagcccacc    898

 accatttcac tga                                                       911




      <210> 42
      <211> 663
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(546)

      <400> 42
  atg ttt ttc atg aag ttt tat gaa gat tct gtt ttt ccc aaa gga gaa      48
  Met Phe Phe Met Lys Phe Tyr Glu Asp Ser Val Phe Pro Lys Gly Glu
    1               5                  10                  15

 ata gcc aaa gct gtg ttt att gat agc tgt gat gag gaa aat gaa ggc       96
 Ile Ala Lys Ala Val Phe Ile Asp Ser Cys Asp Glu Glu Asn Glu Gly
              20                  25                  30

 caa cag gta gca gtg ggg gag gtt cct tca agt ctt cat acc acc cat      144
 Gln Gln Val Ala Val Gly Glu Val Pro Ser Ser Leu His Thr Thr His
          35                  40                  45

 tac aag gaa aac ttt agc atc cgc ctt tca ggg ttt cca gat ctt aga      192
 Tyr Lys Glu Asn Phe Ser Ile Arg Leu Ser Gly Phe Pro Asp Leu Arg
      50                  55                  60

 gct act gtg aag ggg atg tgt ctt cag aga agg ggt ggg caa aac cag      240
 Ala Thr Val Lys Gly Met Cys Leu Gln Arg Arg Gly Gly Gln Asn Gln
  65                  70                  75                  80

 gag gtt ttt gta ata cac tta cac agt gtg act atg gga aca aca gac      288
 Glu Val Phe Val Ile His Leu His Ser Val Thr Met Gly Thr Thr Asp
                  85                  90                  95

 tcg ctt ttg gga agg gga acc aag tgg tgg tca tac caa gta ggt cct      336
 Ser Leu Leu Gly Arg Gly Thr Lys Trp Trp Ser Tyr Gln Val Gly Pro
             100                 105                 110

 gtg agt ttg tgc aat ggt gtc acc tac ggt atg aat act gga gga aca      384
 Val Ser Leu Cys Asn Gly Val Thr Tyr Gly Met Asn Thr Gly Gly Thr
         115                 120                 125

 att gat aaa ctc aca ttt ggg aaa ggg acc cat gta ttc att ata tct      432
 Ile Asp Lys Leu Thr Phe Gly Lys Gly Thr His Val Phe Ile Ile Ser
     130                 135                 140

 ggt gag tca tcc cag gtg gca cca cgt gca acc cca tgg gcc agt gtc      480
 Gly Glu Ser Ser Gln Val Ala Pro Arg Ala Thr Pro Trp Ala Ser Val
 145                 150                 155                 160

 act aat cct ttc tct gga gat atc act tat tac tat ggt gag gct tgc      528
 Thr Asn Pro Phe Ser Gly Asp Ile Thr Tyr Tyr Tyr Gly Glu Ala Cys
                 165                 170                 175

 tgt aga tgt tgt aac taa ttttct tacagaggtc tgggaaggga aaagcattac      582
 Cys Arg Cys Cys Asn 
             180

 tatctatctt gaatattcat ggttctttag gtcaaacaca ttaaaatttg actttaatca    642

 ttcaatgggt atttgaaaat g                                              663




      <210> 43
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(570)

      <400> 43
 tttcgtgtgc ctaga atg ggc att gtc tct gct gcc ccc acc ctt gga ata      51
                  Met Gly Ile Val Ser Ala Ala Pro Thr Leu Gly Ile
                    1               5                  10

 tct cgc ctc tcc cca gtc acc tgg ggg tgg gtt ctg ttt gag tta ggt       99
 Ser Arg Leu Ser Pro Val Thr Trp Gly Trp Val Leu Phe Glu Leu Gly
          15                  20                  25

 gtc tgc gcc cac ccc gga gac ctc tct cgt gga aga ggc aag agt ggg      147
 Val Cys Ala His Pro Gly Asp Leu Ser Arg Gly Arg Gly Lys Ser Gly
      30                  35                  40

 tgt act ggc ttc ggt cct gac cca ggg ggt tgg ggt ggg ggc ctg act      195
 Cys Thr Gly Phe Gly Pro Asp Pro Gly Gly Trp Gly Gly Gly Leu Thr
  45                  50                  55                  60

 cac cct ccc atc act cct tcc cca ttt cct ttc tct cac cct cct ggg      243
 His Pro Pro Ile Thr Pro Ser Pro Phe Pro Phe Ser His Pro Pro Gly
                  65                  70                  75

 ctc ctt cct ttt ccc aat ccc cct cta ccc ccg tcc aga cta tct ggc      291
 Leu Leu Pro Phe Pro Asn Pro Pro Leu Pro Pro Ser Arg Leu Ser Gly
              80                  85                  90

 ttt ccc tgc tct tgc tcc ttc ctc tcc tgt ctt ctc tct ccc tgc tac      339
 Phe Pro Cys Ser Cys Ser Phe Leu Ser Cys Leu Leu Ser Pro Cys Tyr
          95                 100                 105

 ctt ccc tcc ctg ctt ccc cca ttt ctg tct gcc ctc ctt cca ctt tcc      387
 Leu Pro Ser Leu Leu Pro Pro Phe Leu Ser Ala Leu Leu Pro Leu Ser
     110                 115                 120

 cat ata ttc gcc tgt gtc ctt gct gac tcc tgg gcg agg ctg agt ggc      435
 His Ile Phe Ala Cys Val Leu Ala Asp Ser Trp Ala Arg Leu Ser Gly
 125                 130                 135                 140

 aca gtc act tgg ttc cat gtc acc tcc tcg gtt cca ttt cac ttc ccc      483
 Thr Val Thr Trp Phe His Val Thr Ser Ser Val Pro Phe His Phe Pro
                 145                 150                 155

 cat ccc atc atg tcc tgc gga tgg ttt cct gcc ctg gag tca gag cgg      531
 His Pro Ile Met Ser Cys Gly Trp Phe Pro Ala Leu Glu Ser Glu Arg
             160                 165                 170

 gac cac gtg tcg cat cga gtt gct gtt ttc tgt gca tga tgcttgaatc       580
 Asp His Val Ser His Arg Val Ala Val Phe Cys Ala 
         175                 180

 cgtgacttcc tgggtatttc tggcctcggg ttttcgggga gcctaggcca gttgcgcagg    640

 acatctctct ggttctgtct gtcctggcga gtggatcagg gaccacaaaa ggcagctgag    700

 atgtgaacga cgacccttac tccatgtttt ttcattcttt taaaagcact tttacccctt    760

 tttataatga gtaagtgatc tgtggatgaa gccagggcag accctgggaa               810




      <210> 44
      <211> 5754
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (379)..(5754)

      <400> 44
 tttcgtggga ttactgaaga agaagggggg aaaaaaaaag aaagaaatct gagctttctg     60

 ggaggaaatt caaaggaacc aagagaaatt aacttcgttc tgcaaggact aaagtacagc    120

 aagaggagag aggtcaagcg agaagcgtgc gggaagcaca tgccctgggg aggcatagaa    180

 gccacactgg cagagcggcc agcacaggta gccagcagag gcattcttgg ggctatttga    240

 aaaagtttgg tctgtgaaca aaacagtttc cctggtgact gcaaatccat tgctagctgc    300

 ctctttctcg tctgcccatc actctggtgt ggtacccaga agttgacttc tggttctgta    360

 gaaagagcta ggggaggt  atg atg tgc tta aag atc cta aga ata agc ctg     411
                      Met Met Cys Leu Lys Ile Leu Arg Ile Ser Leu
                        1               5                  10

 gcg att ttg gct ggg tgg gca ctc tgt tct gcc aac tct gag ctg ggc      459
 Ala Ile Leu Ala Gly Trp Ala Leu Cys Ser Ala Asn Ser Glu Leu Gly
              15                  20                  25

 tgg aca cgc aag aaa tcc ttg gtt gag agg gaa cac ctg aat cag gtg      507
 Trp Thr Arg Lys Lys Ser Leu Val Glu Arg Glu His Leu Asn Gln Val
          30                  35                  40

 ctg ttg gaa gga gaa cgt tgt tgg ctg ggg gcc aag gtt cga aga ccc      555
 Leu Leu Glu Gly Glu Arg Cys Trp Leu Gly Ala Lys Val Arg Arg Pro
      45                  50                  55

 aga gct tct cca cag cat cac ctc ttt gga gtc tac ccc agc agg gct      603
 Arg Ala Ser Pro Gln His His Leu Phe Gly Val Tyr Pro Ser Arg Ala
  60                  65                  70                  75

 ggg aac tac cta agg ccc tac ccc gtg ggg gag caa gaa atc cat cat      651
 Gly Asn Tyr Leu Arg Pro Tyr Pro Val Gly Glu Gln Glu Ile His His
                  80                  85                  90

 aca gga cgc agc aaa cca gac act gaa gga aat gct gtg agc ctt gtt      699
 Thr Gly Arg Ser Lys Pro Asp Thr Glu Gly Asn Ala Val Ser Leu Val
              95                 100                 105

 ccc cca gac ctg act gaa aat cca gca gga ctg agg ggt gca gtt gaa      747
 Pro Pro Asp Leu Thr Glu Asn Pro Ala Gly Leu Arg Gly Ala Val Glu
         110                 115                 120

 gag ccg gct gcc cca tgg gta ggg gat agt cct att ggg caa tct gag      795
 Glu Pro Ala Ala Pro Trp Val Gly Asp Ser Pro Ile Gly Gln Ser Glu
     125                 130                 135

 ctg ctg gga gat gat gac gct tat ctc ggc aat caa aga tcc aag gag      843
 Leu Leu Gly Asp Asp Asp Ala Tyr Leu Gly Asn Gln Arg Ser Lys Glu
 140                 145                 150                 155

 tct cta ggt gag gcc ggg att cag aaa ggc tca gcc atg gct gcc act      891
 Ser Leu Gly Glu Ala Gly Ile Gln Lys Gly Ser Ala Met Ala Ala Thr
                 160                 165                 170

 act acc acc gcc att ttc aca acc ctg aac gaa ccc aaa cca gag acc      939
 Thr Thr Thr Ala Ile Phe Thr Thr Leu Asn Glu Pro Lys Pro Glu Thr
             175                 180                 185

 caa agg agg ggc tgg gcc aag tcc agg cag cgt cgc caa gtg tgg aag      987
 Gln Arg Arg Gly Trp Ala Lys Ser Arg Gln Arg Arg Gln Val Trp Lys
         190                 195                 200

 agg cgg gcg gaa gat ggg cag gga gac tcc ggt atc tct tca cat ttc     1035
 Arg Arg Ala Glu Asp Gly Gln Gly Asp Ser Gly Ile Ser Ser His Phe
     205                 210                 215

 caa cct tgg ccc aag cat tcc ctt aaa cac agg gtc aaa aag agt cca     1083
 Gln Pro Trp Pro Lys His Ser Leu Lys His Arg Val Lys Lys Ser Pro
 220                 225                 230                 235

 ccg gag gaa agc aac caa aat ggt gga gag ggc tcc tac cga gaa gca     1131
 Pro Glu Glu Ser Asn Gln Asn Gly Gly Glu Gly Ser Tyr Arg Glu Ala
                 240                 245                 250

 gag acc ttt aac tcc caa gta gga ctg ccc atc tta tac ttc tct ggg     1179
 Glu Thr Phe Asn Ser Gln Val Gly Leu Pro Ile Leu Tyr Phe Ser Gly
             255                 260                 265

 agg cgg gag cgg ctg ctg ctg cgt cca gaa gtg ctg gct gag att ccc     1227
 Arg Arg Glu Arg Leu Leu Leu Arg Pro Glu Val Leu Ala Glu Ile Pro
         270                 275                 280

 cgg gag gcg ttc aca gtg gaa gcc tgg gtt aaa ccg gag gga gga cag     1275
 Arg Glu Ala Phe Thr Val Glu Ala Trp Val Lys Pro Glu Gly Gly Gln
     285                 290                 295

 aac aac cca gcc atc atc gca ggt gtg ttt gat aac tgc tcc cac act     1323
 Asn Asn Pro Ala Ile Ile Ala Gly Val Phe Asp Asn Cys Ser His Thr
 300                 305                 310                 315

 gtc agt gac aaa ggc tgg gcc ctg ggg atc cgc tca ggg aag gac aag     1371
 Val Ser Asp Lys Gly Trp Ala Leu Gly Ile Arg Ser Gly Lys Asp Lys
                 320                 325                 330

 gga aag cgg gat gct cgc ttc ttc ttc tcc ctc tgc acc gac cgc gtg     1419
 Gly Lys Arg Asp Ala Arg Phe Phe Phe Ser Leu Cys Thr Asp Arg Val
             335                 340                 345

 aag aaa gcc acc atc ttg att agc cac agt cgc tac caa cca ggc aca     1467
 Lys Lys Ala Thr Ile Leu Ile Ser His Ser Arg Tyr Gln Pro Gly Thr
         350                 355                 360

 tgg acc cat gtg gca gcc act tac gat gga cgg cac atg gcc ctg tat     1515
 Trp Thr His Val Ala Ala Thr Tyr Asp Gly Arg His Met Ala Leu Tyr
     365                 370                 375

 gtg gat ggc act cag gtg gct agc agt cta gac cag tct ggt ccc ctg     1563
 Val Asp Gly Thr Gln Val Ala Ser Ser Leu Asp Gln Ser Gly Pro Leu
 380                 385                 390                 395

 aac agc ccc ttc atg gca tct tgc cgc tct ttg ctc ctg ggg gga gac     1611
 Asn Ser Pro Phe Met Ala Ser Cys Arg Ser Leu Leu Leu Gly Gly Asp
                 400                 405                 410

 agc tct gag gat ggg cac tat ttc cgt gga cac ctg ggc aca ctg gtt     1659
 Ser Ser Glu Asp Gly His Tyr Phe Arg Gly His Leu Gly Thr Leu Val
             415                 420                 425

 ttc tgg tcg acc gcc ctg cca caa agc cat ttt cag cac agt tct cag     1707
 Phe Trp Ser Thr Ala Leu Pro Gln Ser His Phe Gln His Ser Ser Gln
         430                 435                 440

 cat tca agt ggg gag gag gaa gcg act gac ttg gtc ctg aca gcg agc     1755
 His Ser Ser Gly Glu Glu Glu Ala Thr Asp Leu Val Leu Thr Ala Ser
     445                 450                 455

 ttt gag cct gtg aac aca gag tgg gtt ccc ttt aga gat gag aag tac     1803
 Phe Glu Pro Val Asn Thr Glu Trp Val Pro Phe Arg Asp Glu Lys Tyr
 460                 465                 470                 475

 cca cga ctt gag gtt ctc cag ggc ttt gag cca gag cct gag att ctg     1851
 Pro Arg Leu Glu Val Leu Gln Gly Phe Glu Pro Glu Pro Glu Ile Leu
                 480                 485                 490

 tcg cct ttg cag ccc cca ctc tgt ggg caa aca gtc tgt gac aat gtg     1899
 Ser Pro Leu Gln Pro Pro Leu Cys Gly Gln Thr Val Cys Asp Asn Val
             495                 500                 505

 gaa ttg atc tcc cag tac aat gga tac tgg ccc ctt cgg gga gag aag     1947
 Glu Leu Ile Ser Gln Tyr Asn Gly Tyr Trp Pro Leu Arg Gly Glu Lys
         510                 515                 520

 gtg ata cgc tac cag gtg gtg aac atc tgt gat gat gag ggc cta aac     1995
 Val Ile Arg Tyr Gln Val Val Asn Ile Cys Asp Asp Glu Gly Leu Asn
     525                 530                 535

 ccc att gtg agt gag gag cag att cgt ctg cag cac gag gca ctg aat     2043
 Pro Ile Val Ser Glu Glu Gln Ile Arg Leu Gln His Glu Ala Leu Asn
 540                 545                 550                 555

 gag gcc ttc agc cgc tac aac atc agc tgg cag ctg agc gtc cac cag     2091
 Glu Ala Phe Ser Arg Tyr Asn Ile Ser Trp Gln Leu Ser Val His Gln
                 560                 565                 570

 gtc cac aat tcc acc ctg cga cac cgg gtt gtg ctt gtg aac tgt gag     2139
 Val His Asn Ser Thr Leu Arg His Arg Val Val Leu Val Asn Cys Glu
             575                 580                 585

 ccc agc aag att ggc aat gac cat tgt gac ccc gag tgt gag cac cca     2187
 Pro Ser Lys Ile Gly Asn Asp His Cys Asp Pro Glu Cys Glu His Pro
         590                 595                 600

 ctc aca ggc tat gat ggg ggt gac tgc cgc ctg cag ggc cgc tgc tac     2235
 Leu Thr Gly Tyr Asp Gly Gly Asp Cys Arg Leu Gln Gly Arg Cys Tyr
     605                 610                 615

 tcc tgg aac cgc agg gat ggg ctc tgt cac gtg gag tgt aac aac atg     2283
 Ser Trp Asn Arg Arg Asp Gly Leu Cys His Val Glu Cys Asn Asn Met
 620                 625                 630                 635

 ctg aac gac ttt gac gac gga gac tgc tgc gac ccc cag gtg gct gat     2331
 Leu Asn Asp Phe Asp Asp Gly Asp Cys Cys Asp Pro Gln Val Ala Asp
                 640                 645                 650

 gtg cgc aag acc tgc ttt gac cct gac tca ccc aag agg gca tac atg     2379
 Val Arg Lys Thr Cys Phe Asp Pro Asp Ser Pro Lys Arg Ala Tyr Met
             655                 660                 665

 agt gtg aag gag ctg aag gag gcc ctg cag ctg aac agt act cac ttc     2427
 Ser Val Lys Glu Leu Lys Glu Ala Leu Gln Leu Asn Ser Thr His Phe
         670                 675                 680

 ctc aac atc tac ttt gcc agc tca gtg cgg gaa gac ctt gca ggt gct     2475
 Leu Asn Ile Tyr Phe Ala Ser Ser Val Arg Glu Asp Leu Ala Gly Ala
     685                 690                 695

 gcc acc tgg cct tgg gac aag gac gct gtc act cac ctg ggt ggc att     2523
 Ala Thr Trp Pro Trp Asp Lys Asp Ala Val Thr His Leu Gly Gly Ile
 700                 705                 710                 715

 gtc ctc agc cca gca tat tat ggg atg cct ggc cac acc gac acc atg     2571
 Val Leu Ser Pro Ala Tyr Tyr Gly Met Pro Gly His Thr Asp Thr Met
                 720                 725                 730

 atc cat gaa gtg gga cat gtt ctg gga ctc tac cat gtc ttt aaa gga     2619
 Ile His Glu Val Gly His Val Leu Gly Leu Tyr His Val Phe Lys Gly
             735                 740                 745

 gtc agt gaa aga gaa tcc tgc aat gac ccc tgc aag gag aca gtg cca     2667
 Val Ser Glu Arg Glu Ser Cys Asn Asp Pro Cys Lys Glu Thr Val Pro
         750                 755                 760

 tcc atg gaa acg gga gac ctc tgt gcc gac acc gcc ccc act ccc aag     2715
 Ser Met Glu Thr Gly Asp Leu Cys Ala Asp Thr Ala Pro Thr Pro Lys
     765                 770                 775

 agt gag ctg tgc cgg gaa cca gag ccc act agt gac acc tgt ggc ttc     2763
 Ser Glu Leu Cys Arg Glu Pro Glu Pro Thr Ser Asp Thr Cys Gly Phe
 780                 785                 790                 795

 act cgc ttc cca ggg gct ccg ttc acc aac tac atg agc tac acg gat     2811
 Thr Arg Phe Pro Gly Ala Pro Phe Thr Asn Tyr Met Ser Tyr Thr Asp
                 800                 805                 810

 gat aac tgc act gac aac ttc act cct aac caa gtg gcc cga atg cat     2859
 Asp Asn Cys Thr Asp Asn Phe Thr Pro Asn Gln Val Ala Arg Met His
             815                 820                 825

 tgc tat ttg gac cta gtc tat cag cag tgg act gaa agc aga aag ccc     2907
 Cys Tyr Leu Asp Leu Val Tyr Gln Gln Trp Thr Glu Ser Arg Lys Pro
         830                 835                 840

 acc ccc acc ccc att cca cct atg gtc atc gga cag acc aac aag tcc     2955
 Thr Pro Thr Pro Ile Pro Pro Met Val Ile Gly Gln Thr Asn Lys Ser
     845                 850                 855

 ctc act atc cac tgg ctg cct cct att agt gga gtt gta tat gac agg     3003
 Leu Thr Ile His Trp Leu Pro Pro Ile Ser Gly Val Val Tyr Asp Arg
 860                 865                 870                 875

 gcc tca ggc agc ttg tgt ggc gct tgc act gaa gat ggg acc ttt cgt     3051
 Ala Ser Gly Ser Leu Cys Gly Ala Cys Thr Glu Asp Gly Thr Phe Arg
                 880                 885                 890

 cag tat gtg cac aca gct tcc tcc cgg cgg gtg tgt gac tcc tca ggt     3099
 Gln Tyr Val His Thr Ala Ser Ser Arg Arg Val Cys Asp Ser Ser Gly
             895                 900                 905

 tat tgg acc cca gag gag gct gtg ggg cct cct gat gtg gat cag ccc     3147
 Tyr Trp Thr Pro Glu Glu Ala Val Gly Pro Pro Asp Val Asp Gln Pro
         910                 915                 920

 tgc gag cca agc tta cag gcc tgg agc cct gag gtc cac ctg tac cac     3195
 Cys Glu Pro Ser Leu Gln Ala Trp Ser Pro Glu Val His Leu Tyr His
     925                 930                 935

 atg aac atg acg gtc ccc tgc ccc aca gaa ggc tgt agc ttg gag ctg     3243
 Met Asn Met Thr Val Pro Cys Pro Thr Glu Gly Cys Ser Leu Glu Leu
 940                 945                 950                 955

 ctc ttc caa cac ccg gtc caa gcc gac acc ctc acc ctg tgg gtc act     3291
 Leu Phe Gln His Pro Val Gln Ala Asp Thr Leu Thr Leu Trp Val Thr
                 960                 965                 970

 tcc ttc ttc atg gag tcc tcg cag gtc ctc ttt gac aca gag atc ttg     3339
 Ser Phe Phe Met Glu Ser Ser Gln Val Leu Phe Asp Thr Glu Ile Leu
             975                 980                 985

 ctg gaa aac aag gag tca gtg cac ctg ggc ccc tta gac act ttc tgt     3387
 Leu Glu Asn Lys Glu Ser Val His Leu Gly Pro Leu Asp Thr Phe Cys
         990                 995                1000

 gac atc cca ctc acc atc aaa ctg cac gtg gat ggg aag gtg tcg ggg     3435
 Asp Ile Pro Leu Thr Ile Lys Leu His Val Asp Gly Lys Val Ser Gly
    1005                1010                1015

 gtg aaa gtc tac acc ttt gat gag agg ata gag att gat gca gca ctc     3483
 Val Lys Val Tyr Thr Phe Asp Glu Arg Ile Glu Ile Asp Ala Ala Leu
1020                1025                1030                1035

 ctg act tct cag ccc cac agt ccc ttg tgc tct ggc tgc agg cct gtg     3531
 Leu Thr Ser Gln Pro His Ser Pro Leu Cys Ser Gly Cys Arg Pro Val
                1040                1045                1050

 agg tac cag gtt ctc cgc gat ccc cca ttt gcc agt ggt ttg ccc gtg     3579
 Arg Tyr Gln Val Leu Arg Asp Pro Pro Phe Ala Ser Gly Leu Pro Val
            1055                1060                1065

 gtg gtg aca cat tct cac agg aag ttc acg gac gtg gag gtc aca cct     3627
 Val Val Thr His Ser His Arg Lys Phe Thr Asp Val Glu Val Thr Pro
        1070                1075                1080

 gga cag atg tat cag tac caa gtt cta gct gaa gct gga gga gaa ctg     3675
 Gly Gln Met Tyr Gln Tyr Gln Val Leu Ala Glu Ala Gly Gly Glu Leu
    1085                1090                1095

 gga gaa gct tcg cct cct ctg aac cac att cat gga gct cct tat tgt     3723
 Gly Glu Ala Ser Pro Pro Leu Asn His Ile His Gly Ala Pro Tyr Cys
1100                1105                1110                1115

 gga gat ggg aag gtg tca gag aga ctg gga gaa gag tgt gat gat gga     3771
 Gly Asp Gly Lys Val Ser Glu Arg Leu Gly Glu Glu Cys Asp Asp Gly
                1120                1125                1130

 gac ctt gtg agc gga gat ggc tgc tcc aag gtg tgt gag ctg gag gaa     3819
 Asp Leu Val Ser Gly Asp Gly Cys Ser Lys Val Cys Glu Leu Glu Glu
            1135                1140                1145

 ggt ttc aac tgt gta gga gag cca agc ctt tgc tac atg tat gag gga     3867
 Gly Phe Asn Cys Val Gly Glu Pro Ser Leu Cys Tyr Met Tyr Glu Gly
        1150                1155                1160

 gat ggc ata tgt gaa cct ttt gag aga aaa acc agc att gta gac tgt     3915
 Asp Gly Ile Cys Glu Pro Phe Glu Arg Lys Thr Ser Ile Val Asp Cys
    1165                1170                1175

 ggc atc tac act ccc aaa gga tac ttg gat caa tgg gct acc cgg gct     3963
 Gly Ile Tyr Thr Pro Lys Gly Tyr Leu Asp Gln Trp Ala Thr Arg Ala
1180                1185                1190                1195

 tac tcc tct cat gaa gac aag aag aag tgt cct gtt tcc ttg gta act     4011
 Tyr Ser Ser His Glu Asp Lys Lys Lys Cys Pro Val Ser Leu Val Thr
                1200                1205                1210

 gga gaa cct cat tcc cta att tgc aca tca tac cat cca gat tta ccc     4059
 Gly Glu Pro His Ser Leu Ile Cys Thr Ser Tyr His Pro Asp Leu Pro
            1215                1220                1225

 aac cac cgt ccc cta act ggc tgg ttt ccc tgt gtt gcc agt gaa aat     4107
 Asn His Arg Pro Leu Thr Gly Trp Phe Pro Cys Val Ala Ser Glu Asn
        1230                1235                1240

 gaa act cag gat gac agg agt gaa cag cca gaa ggt agc ctg aag aaa     4155
 Glu Thr Gln Asp Asp Arg Ser Glu Gln Pro Glu Gly Ser Leu Lys Lys
    1245                1250                1255

 gag gat gag gtt tgg ctc aaa gtg tgt ttc aat aga cca gga gag gcc     4203
 Glu Asp Glu Val Trp Leu Lys Val Cys Phe Asn Arg Pro Gly Glu Ala
1260                1265                1270                1275

 aga gca att ttt att ttt ttg aca act gat ggc cta gtt ccc gga gag     4251
 Arg Ala Ile Phe Ile Phe Leu Thr Thr Asp Gly Leu Val Pro Gly Glu
                1280                1285                1290

 cat cag cag ccg aca gtg act ctc tac ctg acc gat gtc cgt gga agc     4299
 His Gln Gln Pro Thr Val Thr Leu Tyr Leu Thr Asp Val Arg Gly Ser
            1295                1300                1305

 aac cac tct ctt gga acc tat gga ctg tca tgc cag cat aat cca ctg     4347
 Asn His Ser Leu Gly Thr Tyr Gly Leu Ser Cys Gln His Asn Pro Leu
        1310                1315                1320

 att atc aat gtg acc cat cac cag aat gtc ctt ttc cac cat acc acc     4395
 Ile Ile Asn Val Thr His His Gln Asn Val Leu Phe His His Thr Thr
    1325                1330                1335

 tca gtg ctg ccg aat ttc tca tcc cca cgg gtc ggc atc tca gct gtg     4443
 Ser Val Leu Pro Asn Phe Ser Ser Pro Arg Val Gly Ile Ser Ala Val
1340                1345                1350                1355

 gct cta agg aca tcc tcc cgc att ggt ctt tcg gct ccc agt aac tgc     4491
 Ala Leu Arg Thr Ser Ser Arg Ile Gly Leu Ser Ala Pro Ser Asn Cys
                1360                1365                1370

 atc tca gag gac gag ggg cag aat cat cag gga cag agc tgt atc cat     4539
 Ile Ser Glu Asp Glu Gly Gln Asn His Gln Gly Gln Ser Cys Ile His
            1375                1380                1385

 cgg ccc tgt ggg aag cag gac agc tgt ccg tca ttg ctg ctt gat cat     4587
 Arg Pro Cys Gly Lys Gln Asp Ser Cys Pro Ser Leu Leu Leu Asp His
        1390                1395                1400

 gct gat gtg gtg aac tgt acc tct ata ggc cca ggt ctc atg aag tgt     4635
 Ala Asp Val Val Asn Cys Thr Ser Ile Gly Pro Gly Leu Met Lys Cys
    1405                1410                1415

 gct atc act tgt caa agg gga ttt gcc ctt cag gcc agc agt ggg cag     4683
 Ala Ile Thr Cys Gln Arg Gly Phe Ala Leu Gln Ala Ser Ser Gly Gln
1420                1425                1430                1435

 tac atc agg ccc atg cag aag gaa att ctg ctc aca tgt tct tct ggg     4731
 Tyr Ile Arg Pro Met Gln Lys Glu Ile Leu Leu Thr Cys Ser Ser Gly
                1440                1445                1450

 cac tgg gac cag aat gtg agc tgc ctt ccc gtg gac tgc ggt gtt ccc     4779
 His Trp Asp Gln Asn Val Ser Cys Leu Pro Val Asp Cys Gly Val Pro
            1455                1460                1465

 gac ccg tct ttg gtg aac tat gca aac ttc tcc tgc tca gag gga acc     4827
 Asp Pro Ser Leu Val Asn Tyr Ala Asn Phe Ser Cys Ser Glu Gly Thr
        1470                1475                1480

 aaa ttt ctg aaa cgc tgc tca atc tct tgt gtc cca cca gcc aag ctg     4875
 Lys Phe Leu Lys Arg Cys Ser Ile Ser Cys Val Pro Pro Ala Lys Leu
    1485                1490                1495

 caa gga ctg agc cca tgg ctg aca tgt ctt gaa gat ggt ctc tgg tct     4923
 Gln Gly Leu Ser Pro Trp Leu Thr Cys Leu Glu Asp Gly Leu Trp Ser
1500                1505                1510                1515

 ctc cct gaa gtc tac tgc aag ttg gag tgt gat gct ccc cct att att     4971
 Leu Pro Glu Val Tyr Cys Lys Leu Glu Cys Asp Ala Pro Pro Ile Ile
                1520                1525                1530

 ctg aat gcc aac ttg ctc ctg cct cac tgc ctc cag gac aac cac gac     5019
 Leu Asn Ala Asn Leu Leu Leu Pro His Cys Leu Gln Asp Asn His Asp
            1535                1540                1545

 gtg ggc acc atc tgc aaa tat gaa tgc aaa cca ggg tac tat gtg gca     5067
 Val Gly Thr Ile Cys Lys Tyr Glu Cys Lys Pro Gly Tyr Tyr Val Ala
        1550                1555                1560

 gaa agt gca gag ggt aaa gtc agg aac aag ctc ctg aag ata caa tgc     5115
 Glu Ser Ala Glu Gly Lys Val Arg Asn Lys Leu Leu Lys Ile Gln Cys
    1565                1570                1575

 ctg gaa ggt gga atc tgg gag caa ggc agc tgc att cct gtg gtg tgt     5163
 Leu Glu Gly Gly Ile Trp Glu Gln Gly Ser Cys Ile Pro Val Val Cys
1580                1585                1590                1595

 gag cca ccc cct cct gtg ttt gaa ggc atg tat gaa tgt acc aat ggc     5211
 Glu Pro Pro Pro Pro Val Phe Glu Gly Met Tyr Glu Cys Thr Asn Gly
                1600                1605                1610

 ttc agc ctg gac agc cag tgt gtg ctc aac tgt aac cag gaa cgt gaa     5259
 Phe Ser Leu Asp Ser Gln Cys Val Leu Asn Cys Asn Gln Glu Arg Glu
            1615                1620                1625

 aag ctt ccc atc ctc tgc act aaa gag ggc ctg tgg acc cag gag ttt     5307
 Lys Leu Pro Ile Leu Cys Thr Lys Glu Gly Leu Trp Thr Gln Glu Phe
        1630                1635                1640

 aag ttg tgt gag aat ctg caa gga gaa tgc cca cca ccc ccc tca gag     5355
 Lys Leu Cys Glu Asn Leu Gln Gly Glu Cys Pro Pro Pro Pro Ser Glu
    1645                1650                1655

 ctg aat tct gtg gag tac aaa tgt gaa caa gga tat ggg att ggt gca     5403
 Leu Asn Ser Val Glu Tyr Lys Cys Glu Gln Gly Tyr Gly Ile Gly Ala
1660                1665                1670                1675

 gtg tgt tcc cca ttg tgt gta atc ccc ccc agt gac ccc gtg atg cta     5451
 Val Cys Ser Pro Leu Cys Val Ile Pro Pro Ser Asp Pro Val Met Leu
                1680                1685                1690

 cct gag aat atc act gct gac act ctg gag cac tgg atg gaa cct gtc     5499
 Pro Glu Asn Ile Thr Ala Asp Thr Leu Glu His Trp Met Glu Pro Val
            1695                1700                1705

 aaa gtc cag agc att gtg tgc act ggc cgg cgt caa tgg cac cca gac     5547
 Lys Val Gln Ser Ile Val Cys Thr Gly Arg Arg Gln Trp His Pro Asp
        1710                1715                1720

 ccc gtc tta gtc cac tgc atc cag tca tgt gag ccc ttc caa gca aat     5595
 Pro Val Leu Val His Cys Ile Gln Ser Cys Glu Pro Phe Gln Ala Asn
    1725                1730                1735

 ggt tgg tgt gac act atc aac aac cga gcc tac tgc cac tat gac ggg     5643
 Gly Trp Cys Asp Thr Ile Asn Asn Arg Ala Tyr Cys His Tyr Asp Gly
1740                1745                1750                1755

 gga gac tgc tgc tct tcc aca ctc tcc tcc aag aag gtc att cca ttt     5691
 Gly Asp Cys Cys Ser Ser Thr Leu Ser Ser Lys Lys Val Ile Pro Phe
                1760                1765                1770

 gct gct gac tgt gac ctg gat gag tgc acc tgc cgg gac ccc aag gca     5739
 Ala Ala Asp Cys Asp Leu Asp Glu Cys Thr Cys Arg Asp Pro Lys Ala
            1775                1780                1785

 gaa gaa aat cag taa                                                 5754
 Glu Glu Asn Gln 
        1790





      <210> 45
      <211> 615
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(390)

      <400> 45
  atg agc cat ttg cag agc tta ttg tta gac acc ctc ttg gga acc aag      48
  Met Ser His Leu Gln Ser Leu Leu Leu Asp Thr Leu Leu Gly Thr Lys
    1               5                  10                  15

 cat gtg gac agt gca gcc ctc atc aaa atc cag gag cgg agc ttg tgt       96
 His Val Asp Ser Ala Ala Leu Ile Lys Ile Gln Glu Arg Ser Leu Cys
              20                  25                  30

 gta gca tca cca ggt ttc aat gta acg ccc agt gat gtc cga aca ctg      144
 Val Ala Ser Pro Gly Phe Asn Val Thr Pro Ser Asp Val Arg Thr Leu
          35                  40                  45

 gtg aat gga ttt gcc aag aac cct ttg caa gcc cga aga gaa gga ctg      192
 Val Asn Gly Phe Ala Lys Asn Pro Leu Gln Ala Arg Arg Glu Gly Leu
      50                  55                  60

 tat ttc aag gga aaa gat tac aga tgt gtc cgg gca gat gaa tat tct      240
 Tyr Phe Lys Gly Lys Asp Tyr Arg Cys Val Arg Ala Asp Glu Tyr Ser
  65                  70                  75                  80

 ctt tat gcc aaa aat gag aac act ggt gtg gtt gtt gtg aag acc cat      288
 Leu Tyr Ala Lys Asn Glu Asn Thr Gly Val Val Val Val Lys Thr His
                  85                  90                  95

 ctg tat ctt ctg gtg gca act tac act gag ggc atg tat cct agc atc      336
 Leu Tyr Leu Leu Val Ala Thr Tyr Thr Glu Gly Met Tyr Pro Ser Ile
             100                 105                 110

 tgt gtg gaa gcc aca gag agc ctg gga gac tac cta aga aaa aaa gga      384
 Cys Val Glu Ala Thr Glu Ser Leu Gly Asp Tyr Leu Arg Lys Lys Gly
         115                 120                 125

 agt taa gtcatcagag gcccatgaaa gacactttta ttattttaga agaaaattga       440
 Ser 


 agagcctaaa gaaaaaatat tttatggttg aaaaaacact agacagaagg cactaaaaaa    500

 gaagaatgaa ttaagggagc aatttttatt acttccagag atcctcttct ttcactggaa    560

 ttacttgatc aactgttttt taataagtgt tggtcatcgg catggaaaaa aaaaa         615




      <210> 46
      <211> 885
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(761)

      <400> 46
 cgcctaccaa acaaagcagt ctcaccaggg gctgcagaaa atcccgcttc aagcgggatt     60

 ttttttgccc ggacggcggc aaggcgacca ttcgctctgt cgcatgcgtt gatcaccatc    120

 agggttactg ctgcgccagg tgctgtgtgc gctgcctaga atctgttgca ggcaatagat    180

 caattgcccg tacaagcacg tacaagagga gaagcattgc a    atg caa gag acg     233
                                                  Met Gln Glu Thr
                                                    1

 aca aca gcc gcc gcc ccc agc gct cag cgc gtg atc aag aaa tac ccc      281
 Thr Thr Ala Ala Ala Pro Ser Ala Gln Arg Val Ile Lys Lys Tyr Pro
   5                  10                  15                  20

 aac cgc cgt ctc tac gac acc aac acg tcc tcc tac atc acg ctg acg      329
 Asn Arg Arg Leu Tyr Asp Thr Asn Thr Ser Ser Tyr Ile Thr Leu Thr
                  25                  30                  35

 gaa gtc aag cag ctg gta atg agc aac gag ccc gtg gtg gtc aag gac      377
 Glu Val Lys Gln Leu Val Met Ser Asn Glu Pro Val Val Val Lys Asp
              40                  45                  50

 ccc aag agc ggc gaa gac ctc acg cgc agc atc ctg ctg cag atc att      425
 Pro Lys Ser Gly Glu Asp Leu Thr Arg Ser Ile Leu Leu Gln Ile Ile
          55                  60                  65

 ccg gaa gaa gag gcc ggc ggc gcg ccc atg ttc tcc gag acc gtg ctg      473
 Pro Glu Glu Glu Ala Gly Gly Ala Pro Met Phe Ser Glu Thr Val Leu
      70                  75                  80

 gcc aac atc atc cgt ttc tac ggc cat gcc atg cag ggc tac atg ggt      521
 Ala Asn Ile Ile Arg Phe Tyr Gly His Ala Met Gln Gly Tyr Met Gly
  85                  90                  95                 100

 tcc tac ctg gaa aag aac gtg cag atg ttc acc gac ttc cag aac aag      569
 Ser Tyr Leu Glu Lys Asn Val Gln Met Phe Thr Asp Phe Gln Asn Lys
                 105                 110                 115

 ctg gcc gag cag gcc cag ggc acc tcg ccc gag gct tgg agc cag ttc      617
 Leu Ala Glu Gln Ala Gln Gly Thr Ser Pro Glu Ala Trp Ser Gln Phe
             120                 125                 130

 atg cgc atg cag ccg cca gcc atg cag aac atg atg agc agc tac atg      665
 Met Arg Met Gln Pro Pro Ala Met Gln Asn Met Met Ser Ser Tyr Met
         135                 140                 145

 gag cag tcg cag aac atg ttc acc cag atg cag gac cag atg caa aag      713
 Glu Gln Ser Gln Asn Met Phe Thr Gln Met Gln Asp Gln Met Gln Lys
     150                 155                 160

 cag acc gag cag atg ctg ggt gcg ctc ggg atc aag cgc aat agc tga      761
 Gln Thr Glu Gln Met Leu Gly Ala Leu Gly Ile Lys Arg Asn Ser 
 165                 170                 175

 gcttgcaggg ataagttcag gggcggttta ccaagttcgc gcagaactgg gacaatatcg    821

 cccctatgac ccccacgagc gacgcaacaa ccatgacaac cccctcgtgc caagcttggc    881

 gtaa                                                                 885




      <210> 47
      <211> 2239
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (598)..(2115)

      <400> 47
 ggcctttgag ctcccctgga ctatgtccct tagggcacct ggaggtccgt aggaagcagg     60

 ctcgaggggg gaaggcggcg cggataaagg ctgagggccg cgcgcttggc ccagaccggc    120

 ccggccagcg cgcattcggc cccggacgaa ggtactcgca gcacttggag cgcagaaccg    180

 gccgcgcccg atcctccgag cggcggcgac ggctgttgct aagggagggg acgcgcgagg    240

 aagcgcgacc cgggcggcag acggcaccca gcgccaccag ccgagcggcg ccccctcccc    300

 aggaccctta accgcgccgc gtcccggtcg cgcccgccgc cctttgaagg agaagcaagt    360

 gccgtcccca cccccggaag gcgcccccag gagccggagc gacctcggag cgccactcgg    420

 attttggatt tcggtctcgc attccgcggc cgggactttc tcgaggagga cgcgcgctgc    480

 tccgcgcccc cgagtgcccg gaggacccgg catccgggga gcctctcgcc cctgtcccgg    540

 aggcgcggcg aggattggcg gcgcccgccg cccccagccc cccagcgcgc gccgggg       597                                                                 
 atg gag ccg cag ccc ggc ggc gcc cgg agc tgc cgg cgc ggg gcc ccc      645
 Met Glu Pro Gln Pro Gly Gly Ala Arg Ser Cys Arg Arg Gly Ala Pro
   1               5                  10                  15

 ggc ggc gcc tgc gag ctg ggc ccg gcg gcc gag gcg gcg ccc atg agc      693
 Gly Gly Ala Cys Glu Leu Gly Pro Ala Ala Glu Ala Ala Pro Met Ser
              20                  25                  30

 ctc gct atc cac agc acc acg ggc acc cgc tac gac ctg gcc gtg ccg      741
 Leu Ala Ile His Ser Thr Thr Gly Thr Arg Tyr Asp Leu Ala Val Pro
          35                  40                  45

 ccc gac gag acg gtg gag ggg ctg cgc aag cgg ttg tcc cag cgc ctc      789
 Pro Asp Glu Thr Val Glu Gly Leu Arg Lys Arg Leu Ser Gln Arg Leu
      50                  55                  60

 aaa gtg ccc aag gag cgc ctg gct ctt ctc cac aaa gac acc cgg ctc      837
 Lys Val Pro Lys Glu Arg Leu Ala Leu Leu His Lys Asp Thr Arg Leu
  65                  70                  75                  80

 agt tcg ggg aag ctg cag gag ttc ggc gtg ggt gat ggc agc aag ctg      885
 Ser Ser Gly Lys Leu Gln Glu Phe Gly Val Gly Asp Gly Ser Lys Leu
                  85                  90                  95

 acc ttg gta ccc acc gtg gaa gcg ggc ctc atg tct cag gcc tca agg      933
 Thr Leu Val Pro Thr Val Glu Ala Gly Leu Met Ser Gln Ala Ser Arg
             100                 105                 110

 ccg gaa cag tcc gtg atg caa gct ctc gag agt ctc acg gag acg cag      981
 Pro Glu Gln Ser Val Met Gln Ala Leu Glu Ser Leu Thr Glu Thr Gln
         115                 120                 125

 gtc agt gac ttc ctg tcg ggc cgt tcg cca ctg aca ctg gcc ttg cgt     1029
 Val Ser Asp Phe Leu Ser Gly Arg Ser Pro Leu Thr Leu Ala Leu Arg
     130                 135                 140

 gtg ggc gac cac atg atg ttc gtg cag ctg cag ctc gcg gcc cag cac     1077
 Val Gly Asp His Met Met Phe Val Gln Leu Gln Leu Ala Ala Gln His
 145                 150                 155                 160

 gct cca ctg caa cac cgc cat gtg ctg gcc gct gcg gcc gcc gcc gct     1125
 Ala Pro Leu Gln His Arg His Val Leu Ala Ala Ala Ala Ala Ala Ala
                 165                 170                 175

 gct gcg cgg ggg gac ccc agc ata gcc tcc ccc gtg tcc tcg ccc tgc     1173
 Ala Ala Arg Gly Asp Pro Ser Ile Ala Ser Pro Val Ser Ser Pro Cys
             180                 185                 190

 cgg ccg gtg tcc agt gcc gcc cga gtc ccc ccg gtg ccc acc agc ccg     1221
 Arg Pro Val Ser Ser Ala Ala Arg Val Pro Pro Val Pro Thr Ser Pro
         195                 200                 205

 tcc cct gca tct ccc tcg ccc atc aca gcc ggc tcc ttc cgg tcc cac     1269
 Ser Pro Ala Ser Pro Ser Pro Ile Thr Ala Gly Ser Phe Arg Ser His
     210                 215                 220

 gca gcc tcc acc acc tgc ccg gag cag atg gac tgc tcc ccc acg gcc     1317
 Ala Ala Ser Thr Thr Cys Pro Glu Gln Met Asp Cys Ser Pro Thr Ala
 225                 230                 235                 240

 agc agc agt gcc agt cct ggt gcc agc acc acg tct acc cca ggg gcc     1365
 Ser Ser Ser Ala Ser Pro Gly Ala Ser Thr Thr Ser Thr Pro Gly Ala
                 245                 250                 255

 agc cct gcc ccc cgc tcc cga aaa ccc ggc gcc gtc atc gag agc ttt     1413
 Ser Pro Ala Pro Arg Ser Arg Lys Pro Gly Ala Val Ile Glu Ser Phe
             260                 265                 270

 gtg aat cac gcc ccg ggg gtc ttc tca ggg acc ttc tct gcc cac atg     1461
 Val Asn His Ala Pro Gly Val Phe Ser Gly Thr Phe Ser Ala His Met
         275                 280                 285

 tcc acg cca ttg cct gag ctc atg agc tca cac ccg tgg acg ccc gtc     1509
 Ser Thr Pro Leu Pro Glu Leu Met Ser Ser His Pro Trp Thr Pro Val
     290                 295                 300

 ctg gac atg cgg gac tgt gcc cgt gcc ggg cac tca cgg cca cct ctg     1557
 Leu Asp Met Arg Asp Cys Ala Arg Ala Gly His Ser Arg Pro Pro Leu
 305                 310                 315                 320

 ccc gca ggc acg cta cac ccc aac tgc caa gac agc agc ggg cgg ccg     1605
 Pro Ala Gly Thr Leu His Pro Asn Cys Gln Asp Ser Ser Gly Arg Pro
                 325                 330                 335

 cgg cgt gac atc ggc acc atc ctg cag atc ctg aac gac ctc ctg agc     1653
 Arg Arg Asp Ile Gly Thr Ile Leu Gln Ile Leu Asn Asp Leu Leu Ser
             340                 345                 350

 gcc acc cgg cac tac cag ggc atg ccc cct tcg ctg gcc cag ctc cgc     1701
 Ala Thr Arg His Tyr Gln Gly Met Pro Pro Ser Leu Ala Gln Leu Arg
         355                 360                 365

 tgc cac gcc cag tgc tcc ccg gcc tca ccg gcc ccc gac ctg gcc ccc     1749
 Cys His Ala Gln Cys Ser Pro Ala Ser Pro Ala Pro Asp Leu Ala Pro
     370                 375                 380

 aga act acc tcc tgc gag aag ctc acg gct gcc ccc tca gcc tcc ctg     1797
 Arg Thr Thr Ser Cys Glu Lys Leu Thr Ala Ala Pro Ser Ala Ser Leu
 385                 390                 395                 400

 ctg cag ggc cag agc cag atc cgc atg tgc aag ccc ccg ggg gat cgg     1845
 Leu Gln Gly Gln Ser Gln Ile Arg Met Cys Lys Pro Pro Gly Asp Arg
                 405                 410                 415

 ctt cgg cag aca gaa aac cgc gcc acg cgc tgc aag gtg gaa cgg ctg     1893
 Leu Arg Gln Thr Glu Asn Arg Ala Thr Arg Cys Lys Val Glu Arg Leu
             420                 425                 430

 cag ctg ctt ctg cag cag aaa cgg ctc cgt aga aag gcc cgg cgg gac     1941
 Gln Leu Leu Leu Gln Gln Lys Arg Leu Arg Arg Lys Ala Arg Arg Asp
         435                 440                 445

 gcg cgg ggt ccg tac cac tgg tca ccc agc cgc aag gcc ggc cgc agc     1989
 Ala Arg Gly Pro Tyr His Trp Ser Pro Ser Arg Lys Ala Gly Arg Ser
     450                 455                 460

 gac agc agt agc agc ggg ggc ggc ggc agc ccc agc gag gcc tcc ggc     2037
 Asp Ser Ser Ser Ser Gly Gly Gly Gly Ser Pro Ser Glu Ala Ser Gly
 465                 470                 475                 480

 ttg ggc ctc gac ttc gag gac tcc gtg tgg aag cca gaa gtc aac cct     2085
 Leu Gly Leu Asp Phe Glu Asp Ser Val Trp Lys Pro Glu Val Asn Pro
                 485                 490                 495

 gac atc aag tca gag ttc gtg gtg gct tag g atcttcggat cggccaccct     2136
 Asp Ile Lys Ser Glu Phe Val Val Ala 
             500                 505

 cgcccctcgc accccagccc agggcggcgg ggactccgag agcccggaga gaacgtggcc   2196

 ccagccctgg agggcagggc ggccactccc ccagccagaa gtc                     2239




      <210> 48
      <211> 2189
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (144)..(2114)

      <400> 48
 gggtctgtga agaccatgct gacctgagcc tggcaagatg gtacaggggt tcaacaatcc     60

 cctgccacat ccttcttcag gctctgctaa ttcagccgtg tccctctccc tctgcccgtt    120

 cccctacagg acacttcacg gcc    atg gta tgg aag aac acc aag aag atg     170
                              Met Val Trp Lys Asn Thr Lys Lys Met
                                1               5

 ggc gtg ggg aag gcg tcc gca agt gac ggg tcc tcc ttt gtg gtg gcc      218
 Gly Val Gly Lys Ala Ser Ala Ser Asp Gly Ser Ser Phe Val Val Ala
  10                  15                  20                  25

 aga tac ttc cca gcg ggg aat gtt gtc aat gag ggc ttc ttc gaa gaa      266
 Arg Tyr Phe Pro Ala Gly Asn Val Val Asn Glu Gly Phe Phe Glu Glu
                  30                  35                  40

 aac gtc ctg ccg ccg aag aag cct gag aaa gtc tgc tct cca gta cct      314
 Asn Val Leu Pro Pro Lys Lys Pro Glu Lys Val Cys Ser Pro Val Pro
              45                  50                  55

 gct gct gat ctg ttt cag ccg aca aga ggc acc atg aaa ttg gaa ttc      362
 Ala Ala Asp Leu Phe Gln Pro Thr Arg Gly Thr Met Lys Leu Glu Phe
          60                  65                  70

 acg gag aaa aac tac aat agc ttc gtg ctg cag aac ctg aac aga cag      410
 Thr Glu Lys Asn Tyr Asn Ser Phe Val Leu Gln Asn Leu Asn Arg Gln
      75                  80                  85

 agg aaa cgc aaa gag tac tgg gac atg gcc ctg agt gtg gac aac cac      458
 Arg Lys Arg Lys Glu Tyr Trp Asp Met Ala Leu Ser Val Asp Asn His
  90                  95                 100                 105

 gtc ttc ttt gca cat cgc aat gtg ctg gct gct gtc tcc cca ctg gtg      506
 Val Phe Phe Ala His Arg Asn Val Leu Ala Ala Val Ser Pro Leu Val
                 110                 115                 120

 agg agc ctc atc tcc agc aat gac atg aag acc gct gat gag ctt ttc      554
 Arg Ser Leu Ile Ser Ser Asn Asp Met Lys Thr Ala Asp Glu Leu Phe
             125                 130                 135

 atc acc att gac acc agt tac ctg agc ccg gtc aca gtg gac cag ctt      602
 Ile Thr Ile Asp Thr Ser Tyr Leu Ser Pro Val Thr Val Asp Gln Leu
         140                 145                 150

 ctg gac tac ttc tat agc ggc aag gtg gtg atc tcc gag caa aat gtg      650
 Leu Asp Tyr Phe Tyr Ser Gly Lys Val Val Ile Ser Glu Gln Asn Val
     155                 160                 165

 gag gag ctg ctt cgt ggg gct cag tat ttc aac aca cca cgc ctt cga      698
 Glu Glu Leu Leu Arg Gly Ala Gln Tyr Phe Asn Thr Pro Arg Leu Arg
 170                 175                 180                 185

 gtt cac tgt aac gac ttc ctt att aag tcc atc tgc cgt gcc aac tgc      746
 Val His Cys Asn Asp Phe Leu Ile Lys Ser Ile Cys Arg Ala Asn Cys
                 190                 195                 200

 ttg cgc tac ctc ttc ttg gct gag ctg ttt gag ctc aaa gag gta tca      794
 Leu Arg Tyr Leu Phe Leu Ala Glu Leu Phe Glu Leu Lys Glu Val Ser
             205                 210                 215

 gac gta gct tac tct ggc att cgg gac aac ttc cac tac tgg gcc agt      842
 Asp Val Ala Tyr Ser Gly Ile Arg Asp Asn Phe His Tyr Trp Ala Ser
         220                 225                 230

 cct gag ggc tcc atg cac ttc atg cgc tgt cca cct gtt atc ttt ggc      890
 Pro Glu Gly Ser Met His Phe Met Arg Cys Pro Pro Val Ile Phe Gly
     235                 240                 245

 cgc ctg ctc cgt gat gaa aac ctt cac gtg ctc aat gaa gac cag gcg      938
 Arg Leu Leu Arg Asp Glu Asn Leu His Val Leu Asn Glu Asp Gln Ala
 250                 255                 260                 265

 ctc agc gca ctc atc aat tgg gtg tac ttc cgg aag gag gat cgg gag      986
 Leu Ser Ala Leu Ile Asn Trp Val Tyr Phe Arg Lys Glu Asp Arg Glu
                 270                 275                 280

 aag tat ttc aag aag ttc ttc aat tac atc aat ctc aat gct gtc tcc     1034
 Lys Tyr Phe Lys Lys Phe Phe Asn Tyr Ile Asn Leu Asn Ala Val Ser
             285                 290                 295

 aat aag acg ctg gtg ttt gcc agc aac aag ctg gtg ggc atg gag aac     1082
 Asn Lys Thr Leu Val Phe Ala Ser Asn Lys Leu Val Gly Met Glu Asn
         300                 305                 310

 acc tca tcc cat aca acc ctg att gag agt gtc ctg atg gac cgc aag     1130
 Thr Ser Ser His Thr Thr Leu Ile Glu Ser Val Leu Met Asp Arg Lys
     315                 320                 325

 cag gag cgg cca tgc agc ctg ctg gtc tac cag cgg aaa ggg gcc ctg     1178
 Gln Glu Arg Pro Cys Ser Leu Leu Val Tyr Gln Arg Lys Gly Ala Leu
 330                 335                 340                 345

 ctt gat tcc gtg gtc atc ctc ggt ggc cag aag gcc cac ggc cag ttc     1226
 Leu Asp Ser Val Val Ile Leu Gly Gly Gln Lys Ala His Gly Gln Phe
                 350                 355                 360

 aat gat gga gtg ttt gct tat atc atc cag gag aac ctg tgg atg aag     1274
 Asn Asp Gly Val Phe Ala Tyr Ile Ile Gln Glu Asn Leu Trp Met Lys
             365                 370                 375

 ctt tca gac atg ccc tat cgg gca gca gca ctt agt gcc acc tct gct     1322
 Leu Ser Asp Met Pro Tyr Arg Ala Ala Ala Leu Ser Ala Thr Ser Ala
         380                 385                 390

 ggt cgc tac atc tac atc tct ggt ggc acc act gag cag att tca ggg     1370
 Gly Arg Tyr Ile Tyr Ile Ser Gly Gly Thr Thr Glu Gln Ile Ser Gly
     395                 400                 405

 ctg aag aca gcc tgg cgg tat gac atg gat gac aac tcc tgg acc aag     1418
 Leu Lys Thr Ala Trp Arg Tyr Asp Met Asp Asp Asn Ser Trp Thr Lys
 410                 415                 420                 425

 ttg cct gac ctg ccc atc ggg ctt gtc ttc cac acc atg gtg acc tgt     1466
 Leu Pro Asp Leu Pro Ile Gly Leu Val Phe His Thr Met Val Thr Cys
                 430                 435                 440

 ggg ggg aca gtg tac tca gtg ggc ggg agc att gcc cca agg cgg tat     1514
 Gly Gly Thr Val Tyr Ser Val Gly Gly Ser Ile Ala Pro Arg Arg Tyr
             445                 450                 455

 gtc tcc aac atc tat cgc tat gat gag cgg aag gaa gtc tgg tgc ctg     1562
 Val Ser Asn Ile Tyr Arg Tyr Asp Glu Arg Lys Glu Val Trp Cys Leu
         460                 465                 470

 gca gga aag atg agc atc ccc atg gat ggc acc gcc gtg atc act aaa     1610
 Ala Gly Lys Met Ser Ile Pro Met Asp Gly Thr Ala Val Ile Thr Lys
     475                 480                 485

 gga gac agg cat ctg tac att gtc act gga cgg tgc ttg gtg aaa ggt     1658
 Gly Asp Arg His Leu Tyr Ile Val Thr Gly Arg Cys Leu Val Lys Gly
 490                 495                 500                 505

 tat atc tcc cgg gtc ggg gta gtg gac tgc ttt gac acc agc act ggg     1706
 Tyr Ile Ser Arg Val Gly Val Val Asp Cys Phe Asp Thr Ser Thr Gly
                 510                 515                 520

 gac gtg gtc cag tgt atc acc ttc ccc att gag ttc aac cat cgg ccc     1754
 Asp Val Val Gln Cys Ile Thr Phe Pro Ile Glu Phe Asn His Arg Pro
             525                 530                 535

 ctg ctc tct ttc caa cag gac aac atc ctc tgc gtg cac agc cac cgg     1802
 Leu Leu Ser Phe Gln Gln Asp Asn Ile Leu Cys Val His Ser His Arg
         540                 545                 550

 cag agt gtg gaa atc aat ctg cag aag gtg aag gca agc aag acg acc     1850
 Gln Ser Val Glu Ile Asn Leu Gln Lys Val Lys Ala Ser Lys Thr Thr
     555                 560                 565

 acc tca gtg cct gtc ttg ccc aac agc tgc ccc ttg gat gtg tcc cat     1898
 Thr Ser Val Pro Val Leu Pro Asn Ser Cys Pro Leu Asp Val Ser His
 570                 575                 580                 585

 gct ata tgc tcc att gga gac agc aag gtg ttt gta tgt ggg ggt gtc     1946
 Ala Ile Cys Ser Ile Gly Asp Ser Lys Val Phe Val Cys Gly Gly Val
                 590                 595                 600

 acc act gcc agc gat gtc cag aca aag gac tac acc atc aat cca aat     1994
 Thr Thr Ala Ser Asp Val Gln Thr Lys Asp Tyr Thr Ile Asn Pro Asn
             605                 610                 615

 gcc ttc ttg ctg gac caa aag aca ggc aag tgg aag acc ctg gct cct     2042
 Ala Phe Leu Leu Asp Gln Lys Thr Gly Lys Trp Lys Thr Leu Ala Pro
         620                 625                 630

 cca cca gag gca ctg gac tgt cct gcc tgc tgt cta gcc aag cta cct     2090
 Pro Pro Glu Ala Leu Asp Cys Pro Ala Cys Cys Leu Ala Lys Leu Pro
     635                 640                 645

 tgc aag att ctt caa agg att taa acattttaag tgggagaata agtaaatgca    2144
 Cys Lys Ile Leu Gln Arg Ile 
 650                 655

 ttattattca cgatttaatg agagaaagag aggaaaaaaa aaaaa                   2189




      <210> 49
      <211> 1313
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(1313)

      <400> 49
 caacc    atg caa gga cag ggc agg aga aga gga acc tgc aaa gac ata      47
          Met Gln Gly Gln Gly Arg Arg Arg Gly Thr Cys Lys Asp Ile
            1               5                  10

 ttt tgt tcc aaa atg gca tct tac ctt tat gga gta ctc ttt gct gtt       95
 Phe Cys Ser Lys Met Ala Ser Tyr Leu Tyr Gly Val Leu Phe Ala Val
  15                  20                  25                  30

 ggc ctc tgt gct cca atc tac tgt gtg tcc ccg gcc aat gcc ccc agt      143
 Gly Leu Cys Ala Pro Ile Tyr Cys Val Ser Pro Ala Asn Ala Pro Ser
                  35                  40                  45

 gca tac ccc cgc cct tcc tcc aca aag agc acc cct gcc tca cag gtg      191
 Ala Tyr Pro Arg Pro Ser Ser Thr Lys Ser Thr Pro Ala Ser Gln Val
              50                  55                  60

 tat tcc ctc aac acc gac ttt gcc ttc cgc cta tac cgc agg ctg gtt      239
 Tyr Ser Leu Asn Thr Asp Phe Ala Phe Arg Leu Tyr Arg Arg Leu Val
          65                  70                  75

 ttg gag acc ccg agt cag aac atc ttc ttc tcc cct gtg agt gtc tcc      287
 Leu Glu Thr Pro Ser Gln Asn Ile Phe Phe Ser Pro Val Ser Val Ser
      80                  85                  90

 act tcc ctg gcc atg ctc tcc ctt ggg gcc cac tca gtc acc aag acc      335
 Thr Ser Leu Ala Met Leu Ser Leu Gly Ala His Ser Val Thr Lys Thr
  95                 100                 105                 110

 cag att ctc cag ggc ctg ggc ttc aac ctc aca cac aca cca gag tct      383
 Gln Ile Leu Gln Gly Leu Gly Phe Asn Leu Thr His Thr Pro Glu Ser
                 115                 120                 125

 gcc atc cac cag ggc ttc cag cac ctg gtt cac tca ctg act gtt ccc      431
 Ala Ile His Gln Gly Phe Gln His Leu Val His Ser Leu Thr Val Pro
             130                 135                 140

 agc aaa gac ctg acc ttg aag atg gga agt gcc ctc ttc gtc aag aag      479
 Ser Lys Asp Leu Thr Leu Lys Met Gly Ser Ala Leu Phe Val Lys Lys
         145                 150                 155

 gag ctg cag ctg cag gca aat ttc ttg ggc aat gtc aag agg ctg tat      527
 Glu Leu Gln Leu Gln Ala Asn Phe Leu Gly Asn Val Lys Arg Leu Tyr
     160                 165                 170

 gaa gca gaa gtc ttt tct aca gat ttc tcc aac ccc tcc att gcc cag      575
 Glu Ala Glu Val Phe Ser Thr Asp Phe Ser Asn Pro Ser Ile Ala Gln
 175                 180                 185                 190

 gcg agg atc aac agc cat gtg aaa aag aag acc caa ggg aag gtt gta      623
 Ala Arg Ile Asn Ser His Val Lys Lys Lys Thr Gln Gly Lys Val Val
                 195                 200                 205

 gac ata atc caa ggc ctt gac ctt ctg acg gcc atg gtt ctg gtg aac      671
 Asp Ile Ile Gln Gly Leu Asp Leu Leu Thr Ala Met Val Leu Val Asn
             210                 215                 220

 cac att ttc ttt aaa gcc aag tgg gag aag ccc ttt cac cct gaa tat      719
 His Ile Phe Phe Lys Ala Lys Trp Glu Lys Pro Phe His Pro Glu Tyr
         225                 230                 235

 aca aga aag aac ttc cca ttc ctg gtg ggc gag cag gtc act gtg cat      767
 Thr Arg Lys Asn Phe Pro Phe Leu Val Gly Glu Gln Val Thr Val His
     240                 245                 250

 gtc ccc atg atg cac cag aaa gag cag ttc gct ttt ggg gtg gat aca      815
 Val Pro Met Met His Gln Lys Glu Gln Phe Ala Phe Gly Val Asp Thr
 255                 260                 265                 270

 gag ctg aac tgc ttt gtg ctg cag atg gat tac aag gga gat gcc gtg      863
 Glu Leu Asn Cys Phe Val Leu Gln Met Asp Tyr Lys Gly Asp Ala Val
                 275                 280                 285

 gcc ttc ttt gtc ctc cct agc aag ggc aag atg agg caa ctg gaa cag      911
 Ala Phe Phe Val Leu Pro Ser Lys Gly Lys Met Arg Gln Leu Glu Gln
             290                 295                 300

 gcc ttg tca gcc aga aca ctg aga aag tgg agc cac tca ctc cag aaa      959
 Ala Leu Ser Ala Arg Thr Leu Arg Lys Trp Ser His Ser Leu Gln Lys
         305                 310                 315

 agg tgg ata gag gtg ttc atc ccc aga ttt tcc att tct gcc tcc tac     1007
 Arg Trp Ile Glu Val Phe Ile Pro Arg Phe Ser Ile Ser Ala Ser Tyr
     320                 325                 330

 aat ctg gaa acc atc ctc ccg aag atg ggc atc caa aat gtc ttt gac     1055
 Asn Leu Glu Thr Ile Leu Pro Lys Met Gly Ile Gln Asn Val Phe Asp
 335                 340                 345                 350

 aaa aat gct gat ttt tct gga att gca aag aga gac tcc ctg cag gtt     1103
 Lys Asn Ala Asp Phe Ser Gly Ile Ala Lys Arg Asp Ser Leu Gln Val
                 355                 360                 365

 tct aaa gca acc cac aag gct gtg ctg gat gtc agt gaa gag ggc act     1151
 Ser Lys Ala Thr His Lys Ala Val Leu Asp Val Ser Glu Glu Gly Thr
             370                 375                 380

 gag gcc aca gca gct acc acc acc aag ttc ata gtc cga tcg aag gat     1199
 Glu Ala Thr Ala Ala Thr Thr Thr Lys Phe Ile Val Arg Ser Lys Asp
         385                 390                 395

 ggc ccc tct tac ttc act gtc tcc ttc aat agg acc ttc ctg atg atg     1247
 Gly Pro Ser Tyr Phe Thr Val Ser Phe Asn Arg Thr Phe Leu Met Met
     400                 405                 410

 att aca aat aaa gcc aca gac ggt att ctc ttt cta ggg aaa gtg gaa     1295
 Ile Thr Asn Lys Ala Thr Asp Gly Ile Leu Phe Leu Gly Lys Val Glu
 415                 420                 425                 430

 aat ccc act aaa tcc tag                                             1313
 Asn Pro Thr Lys Ser 
                 435





      <210> 50
      <211> 1879
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (2)..(1825)

      <400> 50
 g    atg gcc gag aag cga agg ggc tcg ccg tgc agc atg cta agc ctc      46
      Met Ala Glu Lys Arg Arg Gly Ser Pro Cys Ser Met Leu Ser Leu
        1               5                  10                  15

 aag gcg cac gct ttc tcg gtg gag gcg ctg atc ggc gcc gag aag cag       94
 Lys Ala His Ala Phe Ser Val Glu Ala Leu Ile Gly Ala Glu Lys Gln
                  20                  25                  30

 caa cag ctt cag aag aag cgg cga aaa ctg ggc gcc gaa gag gcg gcg      142
 Gln Gln Leu Gln Lys Lys Arg Arg Lys Leu Gly Ala Glu Glu Ala Ala
              35                  40                  45

 ggg gcc gtg gac gac gga ggc tgc agc cgc ggc ggc ggc gcg ggc gaa      190
 Gly Ala Val Asp Asp Gly Gly Cys Ser Arg Gly Gly Gly Ala Gly Glu
          50                  55                  60

 aag ggt tct tct gag gga gac gaa ggc gct gcg ctc ccg ccg ccg gct      238
 Lys Gly Ser Ser Glu Gly Asp Glu Gly Ala Ala Leu Pro Pro Pro Ala
      65                  70                  75

 ggg gcg acg tct ggg ccg gct cgg agt ggc gca gac ctg gag cgc gga      286
 Gly Ala Thr Ser Gly Pro Ala Arg Ser Gly Ala Asp Leu Glu Arg Gly
  80                  85                  90                  95

 gcc gcg ggc ggc tgt gag gac ggc ttc cag cag gga gct tcc cct ctg      334
 Ala Ala Gly Gly Cys Glu Asp Gly Phe Gln Gln Gly Ala Ser Pro Leu
                 100                 105                 110

 gcg tca ccg gga ggc tcc ccc aag ggg tct ccg gcg cgc tcc ctg gcc      382
 Ala Ser Pro Gly Gly Ser Pro Lys Gly Ser Pro Ala Arg Ser Leu Ala
             115                 120                 125

 cgg ccc ggg acc cct ctg ccc tcg ccg cag gcc ccg cgg gtg gat ctg      430
 Arg Pro Gly Thr Pro Leu Pro Ser Pro Gln Ala Pro Arg Val Asp Leu
         130                 135                 140

 cag gga gcc gag ctc tgg aag cgc ttt cat gag ata ggc act gag atg      478
 Gln Gly Ala Glu Leu Trp Lys Arg Phe His Glu Ile Gly Thr Glu Met
     145                 150                 155

 atc atc acc aag gcc ggc agg cgc atg ttt cca gca atg aga gtg aag      526
 Ile Ile Thr Lys Ala Gly Arg Arg Met Phe Pro Ala Met Arg Val Lys
 160                 165                 170                 175

 atc tct gga tta gat cct cac cag caa tat tac att gcc atg gat att      574
 Ile Ser Gly Leu Asp Pro His Gln Gln Tyr Tyr Ile Ala Met Asp Ile
                 180                 185                 190

 gta cca gtg gac aac aaa aga tac agg tat gtt tac cac agt tcg aaa      622
 Val Pro Val Asp Asn Lys Arg Tyr Arg Tyr Val Tyr His Ser Ser Lys
             195                 200                 205

 tgg atg gtg gca ggt aat gct gac tcg cct gtg cca ccc cgt gtg tac      670
 Trp Met Val Ala Gly Asn Ala Asp Ser Pro Val Pro Pro Arg Val Tyr
         210                 215                 220

 att cat cca gac tcg cct gcc tcg ggg gag act tgg atg aga caa gtt      718
 Ile His Pro Asp Ser Pro Ala Ser Gly Glu Thr Trp Met Arg Gln Val
     225                 230                 235

 atc agc ttc gac aag ctg aag ctc acc aac aat gaa ctg gat gac caa      766
 Ile Ser Phe Asp Lys Leu Lys Leu Thr Asn Asn Glu Leu Asp Asp Gln
 240                 245                 250                 255

 ggc cat att att ctt cat tct atg cac aaa tac caa ccg cga gtg cac      814
 Gly His Ile Ile Leu His Ser Met His Lys Tyr Gln Pro Arg Val His
                 260                 265                 270

 gtc atc cgt aaa gac tgt gga gac gat ctt tct ccc atc aag cct gtt      862
 Val Ile Arg Lys Asp Cys Gly Asp Asp Leu Ser Pro Ile Lys Pro Val
             275                 280                 285

 cca tcc ggg gag gga gta aag gca ttc tcc ttt cca gaa act gtc ttc      910
 Pro Ser Gly Glu Gly Val Lys Ala Phe Ser Phe Pro Glu Thr Val Phe
         290                 295                 300

 aca acc gtc act gcc tat cag aat cag cag att act cgc ctg aag ata      958
 Thr Thr Val Thr Ala Tyr Gln Asn Gln Gln Ile Thr Arg Leu Lys Ile
     305                 310                 315

 gat agg aat cca ttt gct aaa ggc ttc cga gac tcc ggg cgc aac aga     1006
 Asp Arg Asn Pro Phe Ala Lys Gly Phe Arg Asp Ser Gly Arg Asn Arg
 320                 325                 330                 335

 atg ggt ttg gaa gcc ttg gtg gaa tca tat gca ttc tgg cga cca tca     1054
 Met Gly Leu Glu Ala Leu Val Glu Ser Tyr Ala Phe Trp Arg Pro Ser
                 340                 345                 350

 cta cgg act ctg acc ttt gaa gat atc cct gga att ccc aag caa ggc     1102
 Leu Arg Thr Leu Thr Phe Glu Asp Ile Pro Gly Ile Pro Lys Gln Gly
             355                 360                 365

 aat gca agt tcc tcc acc ttg ctc caa ggt act ggg aat ggc gtt cct     1150
 Asn Ala Ser Ser Ser Thr Leu Leu Gln Gly Thr Gly Asn Gly Val Pro
         370                 375                 380

 gcc act cac cct cac ctt ttg tct ggc tcc tct tgc tcc tct cct gcc     1198
 Ala Thr His Pro His Leu Leu Ser Gly Ser Ser Cys Ser Ser Pro Ala
     385                 390                 395

 ttc cat ctg ggg ccc aac acc agc cag ctg tgt agt ctg gcc cct gct     1246
 Phe His Leu Gly Pro Asn Thr Ser Gln Leu Cys Ser Leu Ala Pro Ala
 400                 405                 410                 415

 gac tat tct gcc tgt gcc cgc tca ggc ctc acc ctc aac cga tac agc     1294
 Asp Tyr Ser Ala Cys Ala Arg Ser Gly Leu Thr Leu Asn Arg Tyr Ser
                 420                 425                 430

 aca tct ttg gca gag acc tac aac agg ctc acc aac cag gct ggt gag     1342
 Thr Ser Leu Ala Glu Thr Tyr Asn Arg Leu Thr Asn Gln Ala Gly Glu
             435                 440                 445

 acc ttt gcc ccg ccc agg act ccc tcc tat gtg ggc gtg agc agc agc     1390
 Thr Phe Ala Pro Pro Arg Thr Pro Ser Tyr Val Gly Val Ser Ser Ser
         450                 455                 460

 acc tcc gtg aac atg tcc atg ggt ggc act gat ggg gac acc ttc agc     1438
 Thr Ser Val Asn Met Ser Met Gly Gly Thr Asp Gly Asp Thr Phe Ser
     465                 470                 475

 tgc cca cag acc agc tta tcc atg cag att tcg gga atg tcc ccc cag     1486
 Cys Pro Gln Thr Ser Leu Ser Met Gln Ile Ser Gly Met Ser Pro Gln
 480                 485                 490                 495

 ctc cag tat atc atg cca tca ccc tcc agc aat gcc ttc gcc act aac     1534
 Leu Gln Tyr Ile Met Pro Ser Pro Ser Ser Asn Ala Phe Ala Thr Asn
                 500                 505                 510

 cag acc cat cag ggt tcc tat aat act ttt aga tta cac agc ccc tgt     1582
 Gln Thr His Gln Gly Ser Tyr Asn Thr Phe Arg Leu His Ser Pro Cys
             515                 520                 525

 gca cta tat gga tat aac ttc tcc aca tcc ccc aaa ctg gct gcc agt     1630
 Ala Leu Tyr Gly Tyr Asn Phe Ser Thr Ser Pro Lys Leu Ala Ala Ser
         530                 535                 540

 cct gag aaa att gtt tct tcc caa gga agt ttc ttg ggg tcc tca ccg     1678
 Pro Glu Lys Ile Val Ser Ser Gln Gly Ser Phe Leu Gly Ser Ser Pro
     545                 550                 555

 agt ggg acc atg acg gat cgg cag atg ttg ccc cct gtg gaa gga gtg     1726
 Ser Gly Thr Met Thr Asp Arg Gln Met Leu Pro Pro Val Glu Gly Val
 560                 565                 570                 575

 cac ctg ctt agc agt ggg ggt cag cag agt ttc ttt gac tct agg acc     1774
 His Leu Leu Ser Ser Gly Gly Gln Gln Ser Phe Phe Asp Ser Arg Thr
                 580                 585                 590

 cta gga agc tta act ctg tca tca tct caa gta tct gca cat atg gtc     1822
 Leu Gly Ser Leu Thr Leu Ser Ser Ser Gln Val Ser Ala His Met Val
             595                 600                 605

 tga tgaa gcccttaagt taaatgacat ttggatctgt ctaacatatt ttctttttct     1879
 






      <210> 51
      <211> 604
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(557)

      <400> 51
 ccagccaact gtaggactaa tcccttcaag cttactcccc cgctgccctc tcctcttctg     60

 ccaacgtgcc cactgacaga aaccaaccag cagcaaaaga cagcctccaa cta   atg     116
                                                              Met
                                                                1

 cca ctg aag aca ttc cca gct gct atc cgg gga gtc atc cag agt gag      164
 Pro Leu Lys Thr Phe Pro Ala Ala Ile Arg Gly Val Ile Gln Ser Glu
               5                  10                  15

 ctc aac tat tct gtg atc ctg cag tgg gtg gtg aca atg gac cct gag      212
 Leu Asn Tyr Ser Val Ile Leu Gln Trp Val Val Thr Met Asp Pro Glu
          20                  25                  30

 cct gtg ctg agc tgg acc ttc agt ggg gtg ccc tgt ggg atg gga gag      260
 Pro Val Leu Ser Trp Thr Phe Ser Gly Val Pro Cys Gly Met Gly Glu
      35                  40                  45

 aag ctg ttc atc cga cgg ttg tcc tgt gag cag ctg ggc acc tac atg      308
 Lys Leu Phe Ile Arg Arg Leu Ser Cys Glu Gln Leu Gly Thr Tyr Met
  50                  55                  60                  65

 tgc ata gcc aca aac agc aag aaa cag ctg gtc tct gag cct gta acc      356
 Cys Ile Ala Thr Asn Ser Lys Lys Gln Leu Val Ser Glu Pro Val Thr
                  70                  75                  80

 atc tcg ctg cca aaa ccc atc atg cag ccc aca gaa gca gag ccc atg      404
 Ile Ser Leu Pro Lys Pro Ile Met Gln Pro Thr Glu Ala Glu Pro Met
              85                  90                  95

 gag cca gac ccc act ctg tcc ctg tca gga ggc tct gcc atc ggg ctc      452
 Glu Pro Asp Pro Thr Leu Ser Leu Ser Gly Gly Ser Ala Ile Gly Leu
         100                 105                 110

 ctt gcg gct ggg atc ctg gga gcc ggg gca ctg att gca ggc atg tgt      500
 Leu Ala Ala Gly Ile Leu Gly Ala Gly Ala Leu Ile Ala Gly Met Cys
     115                 120                 125

 ttc atc atc atc cag agc cta agg act gac agg cag aga ata gga ata      548
 Phe Ile Ile Ile Gln Ser Leu Arg Thr Asp Arg Gln Arg Ile Gly Ile
 130                 135                 140                 145

 tgc agc tga aatgtgg gcaactctcc tgtcagctga agagatgggt gctttgtacc      604
 Cys Ser 






      <210> 52
      <211> 1746
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1104)

      <400> 52
  atg atg cct agt gtc atg aaa gca gga cgc cag aac tgt agc gtt acc      48
  Met Met Pro Ser Val Met Lys Ala Gly Arg Gln Asn Cys Ser Val Thr
    1               5                  10                  15

 agc agc agg caa tgc cta cct ggg aaa ccc tca gaa acc tat aga ggc       96
 Ser Ser Arg Gln Cys Leu Pro Gly Lys Pro Ser Glu Thr Tyr Arg Gly
              20                  25                  30

 agt gtt gtg tgg agt aca cag caa agc cat agg gtt cgt tat gta cca      144
 Ser Val Val Trp Ser Thr Gln Gln Ser His Arg Val Arg Tyr Val Pro
          35                  40                  45

 gca aat gtt cat ggt act gaa gat ata cca gtt gaa gag aaa gaa tgt      192
 Ala Asn Val His Gly Thr Glu Asp Ile Pro Val Glu Glu Lys Glu Cys
      50                  55                  60

 tct tgt tgt cat agt acc tat ttg cta cga gaa ggt gaa gga gcc tat      240
 Ser Cys Cys His Ser Thr Tyr Leu Leu Arg Glu Gly Glu Gly Ala Tyr
  65                  70                  75                  80

 gaa gat caa caa gga gaa ttt cca aga gtc atg tca gcc tcc agt atc      288
 Glu Asp Gln Gln Gly Glu Phe Pro Arg Val Met Ser Ala Ser Ser Ile
                  85                  90                  95

 acc tca aca cat cca act tcc ttc ttg ttg atg ggg att cca ggc ctg      336
 Thr Ser Thr His Pro Thr Ser Phe Leu Leu Met Gly Ile Pro Gly Leu
             100                 105                 110

 gag cac ctg cac atc tgg atc tcc atc ccc ttc tca gca tat aca ctg      384
 Glu His Leu His Ile Trp Ile Ser Ile Pro Phe Ser Ala Tyr Thr Leu
         115                 120                 125

 gcc ctg ctt gga aac tgc acc ctc ctt ctc atc atc cag gct gat gca      432
 Ala Leu Leu Gly Asn Cys Thr Leu Leu Leu Ile Ile Gln Ala Asp Ala
     130                 135                 140

 gcc ctc cat gag ccc ata tac ctc ttt ctg gcc atg ttg gca gcc atc      480
 Ala Leu His Glu Pro Ile Tyr Leu Phe Leu Ala Met Leu Ala Ala Ile
 145                 150                 155                 160

 gac ctg gtc ctt tcc tcc tca gca ttg ccc aaa atg ctt gcc ata ttc      528
 Asp Leu Val Leu Ser Ser Ser Ala Leu Pro Lys Met Leu Ala Ile Phe
                 165                 170                 175

 tgg ttc agg gat cgg gag atc aac ttt ttt gcc tgt ctg gtc cag atg      576
 Trp Phe Arg Asp Arg Glu Ile Asn Phe Phe Ala Cys Leu Val Gln Met
             180                 185                 190

 ttc ttc ctt cac tcc ttc tcc atc atg gag tca gca gtg ctg ctg gcc      624
 Phe Phe Leu His Ser Phe Ser Ile Met Glu Ser Ala Val Leu Leu Ala
         195                 200                 205

 atg gcc ttt gac cgc tat gtg gcc atc tgc aag cca ctg cac tac acc      672
 Met Ala Phe Asp Arg Tyr Val Ala Ile Cys Lys Pro Leu His Tyr Thr
     210                 215                 220

 acg gtc ctg act ggg tcc ctc atc acc aag att ggc atg gct gct gtg      720
 Thr Val Leu Thr Gly Ser Leu Ile Thr Lys Ile Gly Met Ala Ala Val
 225                 230                 235                 240

 gcc cgg gct gtg aca cta atg act cca ctc ccc ttc ctg ctg aga tgt      768
 Ala Arg Ala Val Thr Leu Met Thr Pro Leu Pro Phe Leu Leu Arg Cys
                 245                 250                 255

 ttc cac tac tgc cga ggc cca gtg att gcc cgc tgc tac tgt gaa cac      816
 Phe His Tyr Cys Arg Gly Pro Val Ile Ala Arg Cys Tyr Cys Glu His
             260                 265                 270

 atg gct gtg gca gtt cta caa ctc tcc tct cag gag gcc cgc tac aaa      864
 Met Ala Val Ala Val Leu Gln Leu Ser Ser Gln Glu Ala Arg Tyr Lys
         275                 280                 285

 gca ttt ggg aca tgt gtc tct cac ata ggt gcc atc tta gcc ttc tac      912
 Ala Phe Gly Thr Cys Val Ser His Ile Gly Ala Ile Leu Ala Phe Tyr
     290                 295                 300

 aca cct tca gtc atc tct tca gtc atg cac cgt gtg gcc cgc tgt gct      960
 Thr Pro Ser Val Ile Ser Ser Val Met His Arg Val Ala Arg Cys Ala
 305                 310                 315                 320

 gcg cca cac gtc cac att ctc ctc gcc aat ttc tat ctg ctc ttc cca     1008
 Ala Pro His Val His Ile Leu Leu Ala Asn Phe Tyr Leu Leu Phe Pro
                 325                 330                 335

 ccc atg gtc aat ccc atc atc tac ggc gtt aag acc aag cag atc cgt     1056
 Pro Met Val Asn Pro Ile Ile Tyr Gly Val Lys Thr Lys Gln Ile Arg
             340                 345                 350

 gac agt ctt ggg agt att ccc gag aaa gga tgt gtg aat aga gag tga     1104
 Asp Ser Leu Gly Ser Ile Pro Glu Lys Gly Cys Val Asn Arg Glu 
         355                 360                 365

 ggaataagtg gaaaaagagt ggggcacagt gaatgctgta gtgggccagg gctgtgctga   1164

 gagtagatgg gtcctagact ccacgtttag ttcttttctt gtattatgaa aagaataaat   1224

 gatgtcctga agctcagtgc caacagtctg tttagaattt gtgggtcttt gccctctggt   1284

 agcctctgga ttgaacctgg tgactgtgct gtctcctcac agagccctga ctcctgtcag   1344

 taaacttgac agagtcttga ccctccggcc tcatggtgac tttgctgaag gacacaaaga   1404

 tgcttccaag ttcatttgcc taagagaaga ctgtgaaaat ctgaatttcc atctctgact   1464

 tgttggaaat ttggtgaatt atccactcag attcccgagt taggacctct actccatcca   1524

 gtgcaggagt tctgctacat tctaacagtt gatccctaga ctctacctaa acactgtcag   1584

 tgctggtgca catgcatcct ttaggcctat ttattccaag tgagacagct ctgcttgtta   1644

 aaaggttatt tcttcaatta agccagtctg tattctttga cttcttttta cctcctcatc   1704

 ctcatggcta ttccatctca ttaaatactt tgaaaaaaaa aa                      1746




      <210> 53
      <211> 698
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (96)..(644)

      <400> 53
 agcttcttct ccgaaccaac cctttgcctt cggacttctc cggggccagc agccgcccga     60

 gcaggggccc ggggccacgg gctcagccga cgacc   atg ggc tcc gtg tcc aac     113
                                          Met Gly Ser Val Ser Asn
                                            1               5

 cag cag ttt gca ggt ggc tgc gcc aag gcg gca gaa gag gcg ccc gag      161
 Gln Gln Phe Ala Gly Gly Cys Ala Lys Ala Ala Glu Glu Ala Pro Glu
              10                  15                  20

 gag gcg ccg gag gac gcg gcc cgg gcg gcg gac gag cct cag ctg ctg      209
 Glu Ala Pro Glu Asp Ala Ala Arg Ala Ala Asp Glu Pro Gln Leu Leu
          25                  30                  35

 cac ggt gcg ggc atc tgt aag tgg ttc aac gtg cgc atg ggg ttc ggc      257
 His Gly Ala Gly Ile Cys Lys Trp Phe Asn Val Arg Met Gly Phe Gly
      40                  45                  50

 ttc ctg tcc atg acc gcc cgc gcc ggg gtc gcg ctc gac ccc cca gtg      305
 Phe Leu Ser Met Thr Ala Arg Ala Gly Val Ala Leu Asp Pro Pro Val
  55                  60                  65                  70

 gat gtc ttt gtg cac cag agt aag ctg cac atg gaa ggg ttc cgg agc      353
 Asp Val Phe Val His Gln Ser Lys Leu His Met Glu Gly Phe Arg Ser
                  75                  80                  85

 ttg aag gag ggt gag gca gtg gag ttc acc ttt aag aag tca gcc aag      401
 Leu Lys Glu Gly Glu Ala Val Glu Phe Thr Phe Lys Lys Ser Ala Lys
              90                  95                 100

 ggt ctg gaa tcc atc cgt gtc acc gga cct ggt gga gta ttc tgt att      449
 Gly Leu Glu Ser Ile Arg Val Thr Gly Pro Gly Gly Val Phe Cys Ile
         105                 110                 115

 ggg agt gag agg cgg cca aaa gga aag agc atg cag aag cgc aga tca      497
 Gly Ser Glu Arg Arg Pro Lys Gly Lys Ser Met Gln Lys Arg Arg Ser
     120                 125                 130

 aaa gga gac agg tgc tac aac tgt gga ggt cta gat cat cat gcc aag      545
 Lys Gly Asp Arg Cys Tyr Asn Cys Gly Gly Leu Asp His His Ala Lys
 135                 140                 145                 150

 gaa tgc aag ctg cca ccc cag ccc aag aag tgc cac ttc tgc cag agc      593
 Glu Cys Lys Leu Pro Pro Gln Pro Lys Lys Cys His Phe Cys Gln Ser
                 155                 160                 165

 atc agc cat atg gta gcc tca tgt ccg ctg aag ggc cca gca ggg ccc      641
 Ile Ser His Met Val Ala Ser Cys Pro Leu Lys Gly Pro Ala Gly Pro
             170                 175                 180

 tag tgca cagggaaagc caacctactt tcgagaggaa gaacgaagaa tccacagccc      698
 






      <210> 54
      <211> 615
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(615)

      <400> 54
  atg aag aag cta cta gca atg att ctg tgg ctt caa cta gac cgg tta      48
  Met Lys Lys Leu Leu Ala Met Ile Leu Trp Leu Gln Leu Asp Arg Leu
    1               5                  10                  15

 agt gga gag ctg aaa gtg gaa caa aac cct ctg ttc ctg agc atg cag       96
 Ser Gly Glu Leu Lys Val Glu Gln Asn Pro Leu Phe Leu Ser Met Gln
              20                  25                  30

 gag gga aaa aac tat acc atc tac tgc aat tat tca acc act tca gac      144
 Glu Gly Lys Asn Tyr Thr Ile Tyr Cys Asn Tyr Ser Thr Thr Ser Asp
          35                  40                  45

 aga ctg tat tgg tac agg cag gat cct ggg aaa agt ctg gaa tct ctg      192
 Arg Leu Tyr Trp Tyr Arg Gln Asp Pro Gly Lys Ser Leu Glu Ser Leu
      50                  55                  60

 ttt gtg ttg cta tca aat gga gca gtg aag cag gag gga cga tta atg      240
 Phe Val Leu Leu Ser Asn Gly Ala Val Lys Gln Glu Gly Arg Leu Met
  65                  70                  75                  80

 gcc tca ctt gat acc aaa gcc cgt ctc agc acc ctc cac atc aca gct      288
 Ala Ser Leu Asp Thr Lys Ala Arg Leu Ser Thr Leu His Ile Thr Ala
                  85                  90                  95

 gcc gtg cat gac ctc tct gcc acc tac ttc tgt gcc gtg gac aca cag      336
 Ala Val His Asp Leu Ser Ala Thr Tyr Phe Cys Ala Val Asp Thr Gln
             100                 105                 110

 tgc tcc cct gac gcc acc agt ctg tac cca aac ctg cag ctg tct tac      384
 Cys Ser Pro Asp Ala Thr Ser Leu Tyr Pro Asn Leu Gln Leu Ser Tyr
         115                 120                 125

 tct ggc tgc cgt gct gag aat aga ctg cag atc atc aag atg aaa gtg      432
 Ser Gly Cys Arg Ala Glu Asn Arg Leu Gln Ile Ile Lys Met Lys Val
     130                 135                 140

 ggg aaa att gtt gta tta aca tta aaa cca aag ata tct ggt gtt act      480
 Gly Lys Ile Val Val Leu Thr Leu Lys Pro Lys Ile Ser Gly Val Thr
 145                 150                 155                 160

 ctg agc tca gag gct tct tcc acc aga aaa gct cat tca aga gca gct      528
 Leu Ser Ser Glu Ala Ser Ser Thr Arg Lys Ala His Ser Arg Ala Ala
                 165                 170                 175

 gtt gtt act gct cct gct gat gga aga ggg gct aaa gac ata ttt gat      576
 Val Val Thr Ala Pro Ala Asp Gly Arg Gly Ala Lys Asp Ile Phe Asp
             180                 185                 190

 agc ctt tct gta gat ctc ttg act gca gat gac ctg tga                  615
 Ser Leu Ser Val Asp Leu Leu Thr Ala Asp Asp Leu 
         195                 200





      <210> 55
      <211> 2537
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(1570)

      <400> 55
 cggacgcgtg gggcactctc ctgactcaaa acgatcttct aaactccagc cagtaacaga     60

 agtgaaaact cat   atg cag cat gga tta atc tct ata gca gcc cgc act     109
                  Met Gln His Gly Leu Ile Ser Ile Ala Ala Arg Thr
                    1               5                  10

 gtt att aca cat ctg gta aat cac ctg ggc cat tat cca atg agc ggt      157
 Val Ile Thr His Leu Val Asn His Leu Gly His Tyr Pro Met Ser Gly
          15                  20                  25

 ggt cct gct atg cta aca agt cag gtg tgt gaa aat cac gac aat cat      205
 Gly Pro Ala Met Leu Thr Ser Gln Val Cys Glu Asn His Asp Asn His
      30                  35                  40

 tac agt gaa agt act gaa ctt tct cct gaa ctc ttt gag agt cca aat      253
 Tyr Ser Glu Ser Thr Glu Leu Ser Pro Glu Leu Phe Glu Ser Pro Asn
  45                  50                  55                  60

 atc cag ttc ttt gtg tta aat aat aca acc tta gtg tcc tgt atc cag      301
 Ile Gln Phe Phe Val Leu Asn Asn Thr Thr Leu Val Ser Cys Ile Gln
                  65                  70                  75

 atc aga tca gaa gag aat atg cct gga gga ggt tta tct gct ggc ctt      349
 Ile Arg Ser Glu Glu Asn Met Pro Gly Gly Gly Leu Ser Ala Gly Leu
              80                  85                  90

 gca tca gcc aat tca aat gtc aga atc ata gta cgt gat ctc tct gga      397
 Ala Ser Ala Asn Ser Asn Val Arg Ile Ile Val Arg Asp Leu Ser Gly
          95                 100                 105

 aaa tat tca tgg gat tct gct ata ctg tat ggc cca cct cct ttt aaa      445
 Lys Tyr Ser Trp Asp Ser Ala Ile Leu Tyr Gly Pro Pro Pro Phe Lys
     110                 115                 120

 aga ttt aga gaa act gta cca act tgg gat aca ata aga gat gaa gaa      493
 Arg Phe Arg Glu Thr Val Pro Thr Trp Asp Thr Ile Arg Asp Glu Glu
 125                 130                 135                 140

 gat gct ctt gat gaa ctc ttg cag tat ttg ggt gtt act agt cct gaa      541
 Asp Ala Leu Asp Glu Leu Leu Gln Tyr Leu Gly Val Thr Ser Pro Glu
                 145                 150                 155

 tgc tta cag aga act gga atc tca ctt aat att cct gct cca caa cct      589
 Cys Leu Gln Arg Thr Gly Ile Ser Leu Asn Ile Pro Ala Pro Gln Pro
             160                 165                 170

 gtg tgc att tct gaa aaa caa gaa agt gat gtt att aat gct atc ctt      637
 Val Cys Ile Ser Glu Lys Gln Glu Ser Asp Val Ile Asn Ala Ile Leu
         175                 180                 185

 aag caa cat aca gaa gaa aaa gaa ttt gtt gag aag cac ttt aat gac      685
 Lys Gln His Thr Glu Glu Lys Glu Phe Val Glu Lys His Phe Asn Asp
     190                 195                 200

 tta aac atg aaa gct gtg gaa caa gat gaa cca ata cct caa aaa cct      733
 Leu Asn Met Lys Ala Val Glu Gln Asp Glu Pro Ile Pro Gln Lys Pro
 205                 210                 215                 220

 cag tca gca ttt tat tat tgc aga ttg ctt ctt agt ata ttg gga atg      781
 Gln Ser Ala Phe Tyr Tyr Cys Arg Leu Leu Leu Ser Ile Leu Gly Met
                 225                 230                 235

 aat tcc tgg gac aaa cgg agg agc ttt cat ctc ctg aag aaa aat gaa      829
 Asn Ser Trp Asp Lys Arg Arg Ser Phe His Leu Leu Lys Lys Asn Glu
             240                 245                 250

 aag cta ctt aga gaa ctt agg aac ttg gat tca agg cag tgc cga gag      877
 Lys Leu Leu Arg Glu Leu Arg Asn Leu Asp Ser Arg Gln Cys Arg Glu
         255                 260                 265

 aca cac aag att gca gta ttt tat gtt gct gaa gga caa gaa gac aaa      925
 Thr His Lys Ile Ala Val Phe Tyr Val Ala Glu Gly Gln Glu Asp Lys
     270                 275                 280

 cac tcc att ctc acc aat aca gga gga agt caa gca tat gaa gat ttt      973
 His Ser Ile Leu Thr Asn Thr Gly Gly Ser Gln Ala Tyr Glu Asp Phe
 285                 290                 295                 300

 gta gct ggt ctt ggt tgg gag gta aat ctt aca aac cat tgt ggt ttt     1021
 Val Ala Gly Leu Gly Trp Glu Val Asn Leu Thr Asn His Cys Gly Phe
                 305                 310                 315

 atg gga gga cta caa aaa aac aaa agc act gga ttg acc act cca tat     1069
 Met Gly Gly Leu Gln Lys Asn Lys Ser Thr Gly Leu Thr Thr Pro Tyr
             320                 325                 330

 ttt gct acc tct aca gta gaa gta ata ttt cac atg tca aca aga atg     1117
 Phe Ala Thr Ser Thr Val Glu Val Ile Phe His Met Ser Thr Arg Met
         335                 340                 345

 cct tct gat tct gat gat tct ttg acc aaa aaa ttg aga cat ttg gga     1165
 Pro Ser Asp Ser Asp Asp Ser Leu Thr Lys Lys Leu Arg His Leu Gly
     350                 355                 360

 aat gat gaa gtg cac att gtt tgg tca gag cat act aga gac tac agg     1213
 Asn Asp Glu Val His Ile Val Trp Ser Glu His Thr Arg Asp Tyr Arg
 365                 370                 375                 380

 aga gga att att ccc aca gaa ttt ggt gat gtc ctt att gta ata tat     1261
 Arg Gly Ile Ile Pro Thr Glu Phe Gly Asp Val Leu Ile Val Ile Tyr
                 385                 390                 395

 cca atg aaa aat cac atg ttc agt att cag ata atg aga aaa cca gag     1309
 Pro Met Lys Asn His Met Phe Ser Ile Gln Ile Met Arg Lys Pro Glu
             400                 405                 410

 gtt ccc ttc ttt ggt ccc ctt ttt gat ggt gct att gtg aat gga aag     1357
 Val Pro Phe Phe Gly Pro Leu Phe Asp Gly Ala Ile Val Asn Gly Lys
         415                 420                 425

 gtt cta ccc att atg gtt aga gca aca gct ata aat gca agc cgt gct     1405
 Val Leu Pro Ile Met Val Arg Ala Thr Ala Ile Asn Ala Ser Arg Ala
     430                 435                 440

 ctg aaa tct ctg att cca ttg tat caa aac ttc tat gag gag aga gca     1453
 Leu Lys Ser Leu Ile Pro Leu Tyr Gln Asn Phe Tyr Glu Glu Arg Ala
 445                 450                 455                 460

 cga tac ctg caa aca att gtc cag cac cac tta gaa cca aca aca ttt     1501
 Arg Tyr Leu Gln Thr Ile Val Gln His His Leu Glu Pro Thr Thr Phe
                 465                 470                 475

 gaa gat ttt gca gca cag gtt ttt tct cca gct ccc tac cac cat tta     1549
 Glu Asp Phe Ala Ala Gln Val Phe Ser Pro Ala Pro Tyr His His Leu
             480                 485                 490

 cca tct gat gcc gat cat taa at atcagttctg tttatctgaa ggctcctacc     1602
 Pro Ser Asp Ala Asp His 
         495

 cagagattct acccagtgaa actcccacag caacgcaggt agatggggct gacctggcct   1662

 ctccaatgtc tcctcgaact agcaaaagcc gcatgtccat gaagctgcgt cgttcctctg   1722

 gctcagccaa taaatcctaa ggagacaagc agcccagcag tgatcagcag tagccacctt   1782

 agcacgaaca tagggttaac cctttcaggc cttcatgtct gccataacat gcatgtttct   1842

 tcctgtacat ttatttgaga aaacactgga tttaaataat tttaaataat ttgtagctta   1902

 atattaaaga tttaagttat ttattgtttc atttttttcc cacaatccaa gctgccatat   1962

 tttgagggca gggggagttt tattctacac cctttacctt cctagataat tatgtctaag   2022

 tagttttatc tttaatttca tggttaactg tgagccaaaa tacaattgga caattagtct   2082

 cattatttat tgtgctccat tgcaacttta tggttcaata aatatataat tttttacaaa   2142

 tgtaaaattt tacatttaag catttgtaaa gttacagcaa aagatgtacc tgttaataca   2202

 cagaatgtgt acagattatt tgttatgaca ataaaacact caaaataaat ggtctttagc   2262

 atctcaaatt ccaactgaaa tcattttagt attaactctt cttcccaaag caatgtctca   2322

 tttcttggct gtgcaggtga tgccatgtta tatccaataa ctagaaaaat cactgtgctg   2382

 aacttttatg tttagcttcc aagtattttt ctaatgtttt gcatttcaag tggtatcact   2442

 gttaaatgcc atttgttttc agattgtggc cttttattat tggctgctag atcctggtgt   2502

 ttctatgttc ttttttaagc accaaaaaaa aaaaa                              2537




      <210> 56
      <211> 1601
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(1601)

      <400> 56
 tttgtgaaaa attttaatct cagtactgtg aagaagctgg aaaaagggat att   atg      56
                                                              Met
                                                                1

 ggg cta aaa gct ctc tgt ttg ggg ctg ctt tgt gtt ctt ttt gtc tct      104
 Gly Leu Lys Ala Leu Cys Leu Gly Leu Leu Cys Val Leu Phe Val Ser
               5                  10                  15

 cat ttt tac aca ccc atg cca gac aac att gaa gaa agc tgg aaa ata      152
 His Phe Tyr Thr Pro Met Pro Asp Asn Ile Glu Glu Ser Trp Lys Ile
          20                  25                  30

 atg gcc ttg gat gcc atc gct aaa act tgt aca ttt acg gct atg tgt      200
 Met Ala Leu Asp Ala Ile Ala Lys Thr Cys Thr Phe Thr Ala Met Cys
      35                  40                  45

 ttt gaa aat atg cgt att atg aga tat gaa gag ttt ata tcc atg ata      248
 Phe Glu Asn Met Arg Ile Met Arg Tyr Glu Glu Phe Ile Ser Met Ile
  50                  55                  60                  65

 ttc agg ctg gat tat acc caa cca ctt tca gat gaa tac atc aca gtg      296
 Phe Arg Leu Asp Tyr Thr Gln Pro Leu Ser Asp Glu Tyr Ile Thr Val
                  70                  75                  80

 act gat aca aca ttt gtt gac att cca gta cga ttg tac ttg cca aaa      344
 Thr Asp Thr Thr Phe Val Asp Ile Pro Val Arg Leu Tyr Leu Pro Lys
              85                  90                  95

 aga aag tca gaa acc cga agg cga gct gtg ata tat ttt cat ggt ggt      392
 Arg Lys Ser Glu Thr Arg Arg Arg Ala Val Ile Tyr Phe His Gly Gly
         100                 105                 110

 ggt ttt tgt ttt gga agt tcc aaa cag agg gct ttt gac ttc ctg aat      440
 Gly Phe Cys Phe Gly Ser Ser Lys Gln Arg Ala Phe Asp Phe Leu Asn
     115                 120                 125

 aga tgg acg gca aac acg ctt gat gct gtt gtt gta ggc gtg gac tat      488
 Arg Trp Thr Ala Asn Thr Leu Asp Ala Val Val Val Gly Val Asp Tyr
 130                 135                 140                 145

 agg ctg gct cct caa cac cac ttt cct gct cag ttt gaa gat ggc ctt      536
 Arg Leu Ala Pro Gln His His Phe Pro Ala Gln Phe Glu Asp Gly Leu
                 150                 155                 160

 gct gca gtc aaa ttt ttt ctt ttg gaa aaa att ctt aca aaa tat gga      584
 Ala Ala Val Lys Phe Phe Leu Leu Glu Lys Ile Leu Thr Lys Tyr Gly
             165                 170                 175

 gtg gat ccc acc cga atc tgc att gcg gga gac agt tct ggg ggc aat      632
 Val Asp Pro Thr Arg Ile Cys Ile Ala Gly Asp Ser Ser Gly Gly Asn
         180                 185                 190

 tta gca aca gcg gtc act caa cag gtg cag aat gat gct gaa ata aaa      680
 Leu Ala Thr Ala Val Thr Gln Gln Val Gln Asn Asp Ala Glu Ile Lys
     195                 200                 205

 cat aaa atc aag atg caa gtc tta ctt tac cct ggc tta cag ata aca      728
 His Lys Ile Lys Met Gln Val Leu Leu Tyr Pro Gly Leu Gln Ile Thr
 210                 215                 220                 225

 gat tct tat ttg cca tct cac cga gaa aat gag cat ggt ata gtt ttg      776
 Asp Ser Tyr Leu Pro Ser His Arg Glu Asn Glu His Gly Ile Val Leu
                 230                 235                 240

 acc agg gat gta gcc ata aaa ctc gtg agc tta tat ttc acc aag gat      824
 Thr Arg Asp Val Ala Ile Lys Leu Val Ser Leu Tyr Phe Thr Lys Asp
             245                 250                 255

 gaa gca ctt ccc tgg gca atg aga aga aac caa cac atg cct ctg gag      872
 Glu Ala Leu Pro Trp Ala Met Arg Arg Asn Gln His Met Pro Leu Glu
         260                 265                 270

 tca aga cat ctg ttt aag ttt gtt aac tgg agt att ctt ctt cct gag      920
 Ser Arg His Leu Phe Lys Phe Val Asn Trp Ser Ile Leu Leu Pro Glu
     275                 280                 285

 aag tat aga aaa gac tat gta tat act gaa cca att ctt gga gga ctt      968
 Lys Tyr Arg Lys Asp Tyr Val Tyr Thr Glu Pro Ile Leu Gly Gly Leu
 290                 295                 300                 305

 agt tat tca ttg cca gga ctt aca gac agc aga gca tta ccc ttg ttg     1016
 Ser Tyr Ser Leu Pro Gly Leu Thr Asp Ser Arg Ala Leu Pro Leu Leu
                 310                 315                 320

 gcc aat gat tct cag tta cag aat ttg cca cta acc tat att ctt act     1064
 Ala Asn Asp Ser Gln Leu Gln Asn Leu Pro Leu Thr Tyr Ile Leu Thr
             325                 330                 335

 tgt caa cat gat ctc tta aga gat gat gga ctt atg tat gtt aca aga     1112
 Cys Gln His Asp Leu Leu Arg Asp Asp Gly Leu Met Tyr Val Thr Arg
         340                 345                 350

 ctt cga aat gtt gga gtc caa gtt gtt cat gaa cat att gag gat gga     1160
 Leu Arg Asn Val Gly Val Gln Val Val His Glu His Ile Glu Asp Gly
     355                 360                 365

 att cat gga gct tta tca ttc atg act tca cca ttt tat tta cgt cta     1208
 Ile His Gly Ala Leu Ser Phe Met Thr Ser Pro Phe Tyr Leu Arg Leu
 370                 375                 380                 385

 ggt ctt agg ata aga gat atg tat gct ttg tta gtt gaa ctc ttg gga     1256
 Gly Leu Arg Ile Arg Asp Met Tyr Ala Leu Leu Val Glu Leu Leu Gly
                 390                 395                 400

 atc aat cat ttc atg aat act gca acg ttc ttt gtg agc ttt caa gaa     1304
 Ile Asn His Phe Met Asn Thr Ala Thr Phe Phe Val Ser Phe Gln Glu
             405                 410                 415

 gtc cca cct aca tct gat gaa aat gtc acc atg ata gag aca act ttc     1352
 Val Pro Pro Thr Ser Asp Glu Asn Val Thr Met Ile Glu Thr Thr Phe
         420                 425                 430

 agt aac att cct gtc cgt gta tac atg cca aca cta aag tca gag ata     1400
 Ser Asn Ile Pro Val Arg Val Tyr Met Pro Thr Leu Lys Ser Glu Ile
     435                 440                 445

 cta aga acg ggc tta gtt tat att cat ggt ggt ggt tgg tgt atg ggg     1448
 Leu Arg Thr Gly Leu Val Tyr Ile His Gly Gly Gly Trp Cys Met Gly
 450                 455                 460                 465

 gat gct gat caa ttt gaa gat gta tat aat gca cta aga tgg ttg tta     1496
 Asp Ala Asp Gln Phe Glu Asp Val Tyr Asn Ala Leu Arg Trp Leu Leu
                 470                 475                 480

 tgc caa gat att ctt gaa aaa tat cgt aga gag cct aaa aga att ggc     1544
 Cys Gln Asp Ile Leu Glu Lys Tyr Arg Arg Glu Pro Lys Arg Ile Gly
             485                 490                 495

 att tct gga gac act gct ggt gga aat tta gct gca gca gtg acc caa     1592
 Ile Ser Gly Asp Thr Ala Gly Gly Asn Leu Ala Ala Ala Val Thr Gln
         500                 505                 510

 ctg gta tga                                                         1601
 Leu Val 
     515





      <210> 57
      <211> 629
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(508)

      <400> 57
 caccctccta acagtgcata cggccaacag gattattcac tcactctaca attcatgtag     60

 tctattctct   atg gtg ggc tcc gtg cta ggc act aag gat tta gtg gtg     109
              Met Val Gly Ser Val Leu Gly Thr Lys Asp Leu Val Val
                1               5                  10

 aac aag acc aag atg tgg acc ctg ccc tac tgg agc cca caa tct gat      157
 Asn Lys Thr Lys Met Trp Thr Leu Pro Tyr Trp Ser Pro Gln Ser Asp
      15                  20                  25

 tgg gaa gat aga aag tta aca ata gtg atg tcc agc aag gtg gcc atc      205
 Trp Glu Asp Arg Lys Leu Thr Ile Val Met Ser Ser Lys Val Ala Ile
  30                  35                  40                  45

 aac agt gac att ggg cag gcc ctc tgg gca gtg gag cag ctc cag atg      253
 Asn Ser Asp Ile Gly Gln Ala Leu Trp Ala Val Glu Gln Leu Gln Met
                  50                  55                  60

 gag gca ggc atc gac caa gtg aag gtg agg gtc ggg gcc agt gca gga      301
 Glu Ala Gly Ile Asp Gln Val Lys Val Arg Val Gly Ala Ser Ala Gly
              65                  70                  75

 ggc ggg aag agg tgg gaa cac atg ggc cag ggg aca ggt gca tgc ctg      349
 Gly Gly Lys Arg Trp Glu His Met Gly Gln Gly Thr Gly Ala Cys Leu
          80                  85                  90

 ggt ctg gtc tgg ctg aac cag ttg gtc tgc agg tgt cca aag atg gcc      397
 Gly Leu Val Trp Leu Asn Gln Leu Val Cys Arg Cys Pro Lys Met Ala
      95                 100                 105

 gcc gat ctg ctg aag ttc tgc acg gag cag gcc aag aat gac ccc ttc      445
 Ala Asp Leu Leu Lys Phe Cys Thr Glu Gln Ala Lys Asn Asp Pro Phe
 110                 115                 120                 125

 ctt gtg ggc atc ccg gcc gcc acc aac tcc ttc aag gag aag aag ccc      493
 Leu Val Gly Ile Pro Ala Ala Thr Asn Ser Phe Lys Glu Lys Lys Pro
                 130                 135                 140

 tat gcc atc cta tga acccagggca atgcaccctg tggcctgggc aaaccagggg      548
 Tyr Ala Ile Leu 
             145

 gcctcaataa acatgaagtg aataccttct cagggcatgg ctgagctggg ctgagatgtc    608

 gaccggccgc gaatttagta g                                              629




      <210> 58
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1143)

      <400> 58
  atg gag ttc acg gcg tcc ccc aag ccc caa ctc tcc tcc cgg gcc aac      48
  Met Glu Phe Thr Ala Ser Pro Lys Pro Gln Leu Ser Ser Arg Ala Asn
    1               5                  10                  15

 gcc ttc tcc att gcc gcg ctc atg tcg agc ggc ggc tct aag gag aag       96
 Ala Phe Ser Ile Ala Ala Leu Met Ser Ser Gly Gly Ser Lys Glu Lys
              20                  25                  30

 gag gcg acg gag aac aca atc aaa ccc ctg gag caa ttt gtg gag aag      144
 Glu Ala Thr Glu Asn Thr Ile Lys Pro Leu Glu Gln Phe Val Glu Lys
          35                  40                  45

 tcg tcc tgt gcc cag ccc ctg ggt gag ctg acc agc ctg gat gct cat      192
 Ser Ser Cys Ala Gln Pro Leu Gly Glu Leu Thr Ser Leu Asp Ala His
      50                  55                  60

 ggg gag ttt ggt gga ggc agt ggc agc agc ccg tcc tcc tcc tct ctg      240
 Gly Glu Phe Gly Gly Gly Ser Gly Ser Ser Pro Ser Ser Ser Ser Leu
  65                  70                  75                  80

 tgc act gag cca ctg atc ccc acc acc ccc atc atc ccc agt gag gaa      288
 Cys Thr Glu Pro Leu Ile Pro Thr Thr Pro Ile Ile Pro Ser Glu Glu
                  85                  90                  95

 atg gcc aaa att gcc tgc agc ctg gag acc aag gag ctt tgg gac aaa      336
 Met Ala Lys Ile Ala Cys Ser Leu Glu Thr Lys Glu Leu Trp Asp Lys
             100                 105                 110

 ttc cat gag ctg ggc acc gag atg atc atc acc aag tcg ggc agg agg      384
 Phe His Glu Leu Gly Thr Glu Met Ile Ile Thr Lys Ser Gly Arg Arg
         115                 120                 125

 atg ttt cca acc atc cgg gtg tcc ttt tcg ggg gtg gat cct gag gcc      432
 Met Phe Pro Thr Ile Arg Val Ser Phe Ser Gly Val Asp Pro Glu Ala
     130                 135                 140

 aag tac ata gtc ctg atg gac atc gtc cct gtg gac aac aag agg tac      480
 Lys Tyr Ile Val Leu Met Asp Ile Val Pro Val Asp Asn Lys Arg Tyr
 145                 150                 155                 160

 cgc tac gcc tac cac cgg tcc tcc tgg ctg gtg gct ggc aag gcc gac      528
 Arg Tyr Ala Tyr His Arg Ser Ser Trp Leu Val Ala Gly Lys Ala Asp
                 165                 170                 175

 ccg ccg ttg cca gcc agg ctc tat gtg cat cca gat tct cct ttt acc      576
 Pro Pro Leu Pro Ala Arg Leu Tyr Val His Pro Asp Ser Pro Phe Thr
             180                 185                 190

 ggt gag caa cta ctc aaa cag atg gtg tct ttt gaa aag gtg aaa ctc      624
 Gly Glu Gln Leu Leu Lys Gln Met Val Ser Phe Glu Lys Val Lys Leu
         195                 200                 205

 acc aac aat gaa ctg gat caa cat ggc cat ata att ttg aac tca atg      672
 Thr Asn Asn Glu Leu Asp Gln His Gly His Ile Ile Leu Asn Ser Met
     210                 215                 220

 cat aag tac cag cca agg gtg cac atc att aag aag aaa gac cac aca      720
 His Lys Tyr Gln Pro Arg Val His Ile Ile Lys Lys Lys Asp His Thr
 225                 230                 235                 240

 gcc tca ttg ctc aac ctg aag tct gaa gaa ttt aga act ttc atc ttt      768
 Ala Ser Leu Leu Asn Leu Lys Ser Glu Glu Phe Arg Thr Phe Ile Phe
                 245                 250                 255

 cca gaa aca gtt ttt acg gca gtc act gcc tac cag aat caa ctg cgt      816
 Pro Glu Thr Val Phe Thr Ala Val Thr Ala Tyr Gln Asn Gln Leu Arg
             260                 265                 270

 aag ctt aag ggg ctg tgg cag tac tac act cca cag ata acg aag ctg      864
 Lys Leu Lys Gly Leu Trp Gln Tyr Tyr Thr Pro Gln Ile Thr Lys Leu
         275                 280                 285

 aaa ata gat agc aat cct ttt gcc aaa gga ttc cgg gat tcc tcc agg      912
 Lys Ile Asp Ser Asn Pro Phe Ala Lys Gly Phe Arg Asp Ser Ser Arg
     290                 295                 300

 ctc act gac att gag aga ctc cag ctg tgt ggc aac ctg ttc ccc aaa      960
 Leu Thr Asp Ile Glu Arg Leu Gln Leu Cys Gly Asn Leu Phe Pro Lys
 305                 310                 315                 320

 gaa ctg ctc aaa gat ctg ctt tca tct tta acc cca ttt gct cca agt     1008
 Glu Leu Leu Lys Asp Leu Leu Ser Ser Leu Thr Pro Phe Ala Pro Ser
                 325                 330                 335

 tgg ggt ttt gat gaa gtt cca aca gaa gcc ttg ttt att tcc acc ccg     1056
 Trp Gly Phe Asp Glu Val Pro Thr Glu Ala Leu Phe Ile Ser Thr Pro
             340                 345                 350

 ggt atc ttt ctt cct tat gtg ctg atg gat ggc atg ccg gct ggt gct     1104
 Gly Ile Phe Leu Pro Tyr Val Leu Met Asp Gly Met Pro Ala Gly Ala
         355                 360                 365

 gcc ctt act cct tac ctg tct gtg gct gaa ata ttt taa                 1143
 Ala Leu Thr Pro Tyr Leu Ser Val Ala Glu Ile Phe 
     370                 375                 380





      <210> 59
      <211> 813
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(813)

      <400> 59
  atg aca aga act tat gaa gta aag ttt ggc ctt tgt gta tgg aag agg      48
  Met Thr Arg Thr Tyr Glu Val Lys Phe Gly Leu Cys Val Trp Lys Arg
    1               5                  10                  15

 aat gga gga tgt cgg gat gca ggt caa gga agg cat cct gtg gaa gtg       96
 Asn Gly Gly Cys Arg Asp Ala Gly Gln Gly Arg His Pro Val Glu Val
              20                  25                  30

 aca ttt gag cta ata tct gaa gaa tgg gtg aca gga aga aaa aga atg      144
 Thr Phe Glu Leu Ile Ser Glu Glu Trp Val Thr Gly Arg Lys Arg Met
          35                  40                  45

 ctt cag aga aca gca ggt aca gaa gct gag gtt gaa aag gtg gat gtg      192
 Leu Gln Arg Thr Ala Gly Thr Glu Ala Glu Val Glu Lys Val Asp Val
      50                  55                  60

 tcc agg gaa gag gac agc acc gac gtc tat aat acc agg ggt cgg gtt      240
 Ser Arg Glu Glu Asp Ser Thr Asp Val Tyr Asn Thr Arg Gly Arg Val
  65                  70                  75                  80

 acc atg gat cag gag ttg tcc aaa gag cag aaa gta ttt ttt aaa acg      288
 Thr Met Asp Gln Glu Leu Ser Lys Glu Gln Lys Val Phe Phe Lys Thr
                  85                  90                  95

 gtg caa cat tta ctt aag gtt att cag tgc acc ata gag tct gaa gct      336
 Val Gln His Leu Leu Lys Val Ile Gln Cys Thr Ile Glu Ser Glu Ala
             100                 105                 110

 ttg cat aag ctt atg ttt tta att cgg cag gaa tgc cct tgg ttc cct      384
 Leu His Lys Leu Met Phe Leu Ile Arg Gln Glu Cys Pro Trp Phe Pro
         115                 120                 125

 gac caa gga aca tta gac tta gag tta tgg gag cag gca gat tgc tgc      432
 Asp Gln Gly Thr Leu Asp Leu Glu Leu Trp Glu Gln Ala Asp Cys Cys
     130                 135                 140

 ctg aaa aga gga ttt gag cag gtc cat ttt act aat gtt acc gtt ttg      480
 Leu Lys Arg Gly Phe Glu Gln Val His Phe Thr Asn Val Thr Val Leu
 145                 150                 155                 160

 atc acc tgg agt ctg gca tgt tct gtg ttg tac cct ctt tat atg cca      528
 Ile Thr Trp Ser Leu Ala Cys Ser Val Leu Tyr Pro Leu Tyr Met Pro
                 165                 170                 175

 gat cgt ggt gag tca gat tgc cca ttt tct tca cct gaa ggg aat tcg      576
 Asp Arg Gly Glu Ser Asp Cys Pro Phe Ser Ser Pro Glu Gly Asn Ser
             180                 185                 190

 gaa aat tta aag gaa aag ggg aca cag aaa gca gaa caa cag gaa gga      624
 Glu Asn Leu Lys Glu Lys Gly Thr Gln Lys Ala Glu Gln Gln Glu Gly
         195                 200                 205

 gtt cct ccc cca act tca ctc cct tca gta ggg cat aaa gaa gac act      672
 Val Pro Pro Pro Thr Ser Leu Pro Ser Val Gly His Lys Glu Asp Thr
     210                 215                 220

 ttt tct agt gat gat gag gac gga ctg gag cct ttt cct ctc tca ata      720
 Phe Ser Ser Asp Asp Glu Asp Gly Leu Glu Pro Phe Pro Leu Ser Ile
 225                 230                 235                 240

 gaa aag cca ttg ccc tct ttt cct cca ccc ttc aca cga cct gca tct      768
 Glu Lys Pro Leu Pro Ser Phe Pro Pro Pro Phe Thr Arg Pro Ala Ser
                 245                 250                 255

 gtt ggc ccc att cag gca ata gca cct ccc atc ccc ctt gag tag          813
 Val Gly Pro Ile Gln Ala Ile Ala Pro Pro Ile Pro Leu Glu 
             260                 265                 270





      <210> 60
      <211> 681
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (350)..(679)

      <400> 60
 ctgccaaaaa tagcagtgcc cgtgagagcc cccagtaaca aaaaatttcc gggctgtgtg     60

 cctaataggg ttacagacac agcacactac tttagacagg ggctctctcg cgcgccgtcc    120

 tttattttcg cacatgtgtt tcccatctca ttcaatatgt ggatgacatt tttgtttgca    180

 gcccctctta ccaatcctcc cagcaagaca ctatcctgct tcttcaacac ctctactcca    240

 aggggtacag agtatccccc tccaaagctc aaatttctac ttatcttggt ataatcctcc    300

 accaacatag gtgtgcactt ccagcagacc gtattcagct aatctccaa    atg cca     355
                                                          Met Pro
                                                            1

 atc ccc acc acc aaa caa cta ctc ctc tcc ttc tta gac gtt gtt gga      403
 Ile Pro Thr Thr Lys Gln Leu Leu Leu Ser Phe Leu Asp Val Val Gly
           5                  10                  15

 tac ttc tgc ctt tgg ata cca ggt ttt gcc atc cta acc aaa cca ctc      451
 Tyr Phe Cys Leu Trp Ile Pro Gly Phe Ala Ile Leu Thr Lys Pro Leu
      20                  25                  30

 tat aaa ctc aca aaa gga aac tta gct gaa ccc aca gat cct aaa tcc      499
 Tyr Lys Leu Thr Lys Gly Asn Leu Ala Glu Pro Thr Asp Pro Lys Ser
  35                  40                  45                  50

 ttc cct cgc ccc tcc ttt tac tct aaa aaa ggc cct aga ggc aaa ccc      547
 Phe Pro Arg Pro Ser Phe Tyr Ser Lys Lys Gly Pro Arg Gly Lys Pro
                  55                  60                  65

 tta ctc aag cgc ttc ccg act cct ccc aac ctt cct tcc tct cca cac      595
 Leu Leu Lys Arg Phe Pro Thr Pro Pro Asn Leu Pro Ser Ser Pro His
              70                  75                  80

 agc aaa aac gca ggg ctg cgc tgt agg aat tct tac tca gga acc agg      643
 Ser Lys Asn Ala Gly Leu Arg Cys Arg Asn Ser Tyr Ser Gly Thr Arg
          85                  90                  95

 cct gtg acc agt agc ctt tgt att caa aca gct taa tc                   681
 Pro Val Thr Ser Ser Leu Cys Ile Gln Thr Ala 
     100                 105





      <210> 61
      <211> 464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (120)..(254)

      <400> 61
 gcacgagcca aggtgctcgg tccttccgag gaagctaagg ctgcgttggg gtgaggccct     60

 cacttcatcc ggcgactagc accgcgtccg gcagcgccag ccctacactc gcccgcgcc     119                                                                 
 atg gcc tct gtc tcc gag ctc gcc tgc atc tac tcg gcc ctc att ctg      167
 Met Ala Ser Val Ser Glu Leu Ala Cys Ile Tyr Ser Ala Leu Ile Leu
   1               5                  10                  15

 cac gac gat gag gtg aca gtc acg gtt cag tat ctg aac act ttt gct      215
 His Asp Asp Glu Val Thr Val Thr Val Gln Tyr Leu Asn Thr Phe Ala
              20                  25                  30

 aaa ggt ctc tgg aaa gct ccc tgt gtt aat tct cga tga gactacgtct       264
 Lys Gly Leu Trp Lys Ala Pro Cys Val Asn Ser Arg 
          35                  40

 gtgccggccg cttcctgagc ctccttccat gtgcataggc ctgctgcatg ctggagacct    324

 gcggcacagc tgccaagtgc cccgtgtggt tctgtgatct tgggacagtc acttcctctc    384

 tgtggttgtc agtcttctca tccctaaggt atatccaagt ttataattgt cctattttct    444

 atcttcccga tgttgcaaag                                                464




      <210> 62
      <211> 405
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(363)

      <400> 62
 gtggaaattg cactggctta tttgtagttt ttttttaagc tacaaaacta agaacaaatt     60

 ttagtttatt gaaactaa  atg act ggc aag aga gga aga atg agc agt tcc     111
                      Met Thr Gly Lys Arg Gly Arg Met Ser Ser Ser
                        1               5                  10

 tat gcc atg aag acc ttt gcc ctg gtc ctg ctg atg gcc ctg ctg tgc      159
 Tyr Ala Met Lys Thr Phe Ala Leu Val Leu Leu Met Ala Leu Leu Cys
              15                  20                  25

 atg aag aga gct cag ggt ctg cac tgc tac agg tgc ttg gca gtc tcg      207
 Met Lys Arg Ala Gln Gly Leu His Cys Tyr Arg Cys Leu Ala Val Ser
          30                  35                  40

 gaa agg aac tcc tgc cgt gtg gtc atg ggc ctc ttc cag gag ggg atc      255
 Glu Arg Asn Ser Cys Arg Val Val Met Gly Leu Phe Gln Glu Gly Ile
      45                  50                  55

 tgt gtc tcc cag aaa gta agc acc ttt cag gag atg agg tct tgc ttt      303
 Cys Val Ser Gln Lys Val Ser Thr Phe Gln Glu Met Arg Ser Cys Phe
  60                  65                  70                  75

 gtt ggc att tat ctt gct tgg tgt tct ctg agc ttc ctg gat ctg tgg      351
 Val Gly Ile Tyr Leu Ala Trp Cys Ser Leu Ser Phe Leu Asp Leu Trp
                  80                  85                  90

 ttt ggt gtc tga catgaatttg gggaaattct cagtcattat tgtttcaaac at       405
 Phe Gly Val 






      <210> 63
      <211> 579
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(453)

      <400> 63
  atg gca gag caa aag caa aga aaa atc cct ttg gtt cca gaa aat ctc      48
  Met Ala Glu Gln Lys Gln Arg Lys Ile Pro Leu Val Pro Glu Asn Leu
    1               5                  10                  15

 ctg aaa aag agg aag gct tat caa gtc ctc aaa gcc act cag aca aag       96
 Leu Lys Lys Arg Lys Ala Tyr Gln Val Leu Lys Ala Thr Gln Thr Lys
              20                  25                  30

 cag gca ctt ttg gca aag aag gag cag cgg aaa gga aaa ggg ctc agc      144
 Gln Ala Leu Leu Ala Lys Lys Glu Gln Arg Lys Gly Lys Gly Leu Ser
          35                  40                  45

 aaa agg att gtt ggc gtg agt cta ctg gtg cag aca gcc att gca aga      192
 Lys Arg Ile Val Gly Val Ser Leu Leu Val Gln Thr Ala Ile Ala Arg
      50                  55                  60

 ctt cat ctt aag aaa att ttt agt ggt gtc ttt gta aaa gtc acc ccc      240
 Leu His Leu Lys Lys Ile Phe Ser Gly Val Phe Val Lys Val Thr Pro
  65                  70                  75                  80

 cag aac cta aaa atg ctg cgt ata gtg gaa cct aat gtg atc tgg gga      288
 Gln Asn Leu Lys Met Leu Arg Ile Val Glu Pro Asn Val Ile Trp Gly
                  85                  90                  95

 ttt cca aat ctg aag tct gtc cgg gaa ttc att ctg aaa cat gga caa      336
 Phe Pro Asn Leu Lys Ser Val Arg Glu Phe Ile Leu Lys His Gly Gln
             100                 105                 110

 gcc aag gtc aat aag aac acc atc cct ctg aca gac aac aca gtg att      384
 Ala Lys Val Asn Lys Asn Thr Ile Pro Leu Thr Asp Asn Thr Val Ile
         115                 120                 125

 gag gag cac ctg ggg aag ttt ggt gtc att tgc ttg gaa gac ctc att      432
 Glu Glu His Leu Gly Lys Phe Gly Val Ile Cys Leu Glu Asp Leu Ile
     130                 135                 140

 cat gaa att gcc tcc cag tga ag catttccagg agatctcatg gttcttttgc      485
 His Glu Ile Ala Ser Gln 
 145                 150

 cctttccacc tctcagtggt ccatcatgct accaaaaata cagtgggctt cctcaaggag    545

 atgggcacat acgaaatcgt cgacccgagg aatt                                579




      <210> 64
      <211> 1797
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (502)..(1797)

      <400> 64
 atgcaggtat attctgagaa agggaataag ccatgtataa aaagagattt caccctactc     60

 aataaaactg tggttcttat agatgaagta ggtatcatcc tgcacatctc agctttcggc    120

 tgcaaatggg cttctgaaaa aagctccgag aggaatccag gagggaggga agctctgagc    180

 gaggacgacg aggcgattta tgcaacagta tcctgtttca gcactgccaa ggctatgcga    240

 gaacgcggcc aggacagcct ggcaggactc gtgctgtatg taggactctt cgggcacccc    300

 gggatgctgc acagggccaa gtacagccgc tttcggaacg agtcgatcac gtccttggac    360

 gaaggtagct ccggaggctc ggtcgggaac aagggctcgc cgcagcctcc ccaccccgcc    420

 ctggcacctc acctgccgac tgaagatgcc accttgccgt cgcaggagag ccccacccca    480

 ctgtgcacct tgatcccccg c  atg gca agc atg aag ctg gcc aac ccg gcc     531
                          Met Ala Ser Met Lys Leu Ala Asn Pro Ala
                            1               5                  10

 act ttg ctg agt ctg aaa aac ttt tgc ctg ggt acc aaa gag gtg cct      579
 Thr Leu Leu Ser Leu Lys Asn Phe Cys Leu Gly Thr Lys Glu Val Pro
                  15                  20                  25

 cgg ctg aag ctc cag gaa agc cgg gac cca ggt tcc agc ggc ccc tct      627
 Arg Leu Lys Leu Gln Glu Ser Arg Asp Pro Gly Ser Ser Gly Pro Ser
              30                  35                  40

 tcc cca gaa acc agt tta agt agg tcc ggg act gca cct cca ccg cag      675
 Ser Pro Glu Thr Ser Leu Ser Arg Ser Gly Thr Ala Pro Pro Pro Gln
          45                  50                  55

 cag gac ctg gtg gga cac agg gca acc gcc cta acc cct gat tcg tgc      723
 Gln Asp Leu Val Gly His Arg Ala Thr Ala Leu Thr Pro Asp Ser Cys
      60                  65                  70

 ccg ctt cct ggc cct ggg gag cca aca ctt agg agc agg cag gac agg      771
 Pro Leu Pro Gly Pro Gly Glu Pro Thr Leu Arg Ser Arg Gln Asp Arg
  75                  80                  85                  90

 cac ttt cta cag cac ctg ttg ggg atg ggc atg aac tac tgt gtg agg      819
 His Phe Leu Gln His Leu Leu Gly Met Gly Met Asn Tyr Cys Val Arg
                  95                 100                 105

 tgg gca gca gca gct tcc gag atg tcc tgg gca cca gca tgg gtc tgt      867
 Trp Ala Ala Ala Ala Ser Glu Met Ser Trp Ala Pro Ala Trp Val Cys
             110                 115                 120

 gtg gag gct atg cgg ggc cag cgt atg gga ggc atc aca gcc gtc aca      915
 Val Glu Ala Met Arg Gly Gln Arg Met Gly Gly Ile Thr Ala Val Thr
         125                 130                 135

 gtc aac cag aac gtg ctg agc ccc ctt aac ctg gaa gtg gac ccc aac      963
 Val Asn Gln Asn Val Leu Ser Pro Leu Asn Leu Glu Val Asp Pro Asn
     140                 145                 150

 atg cag ggc atg cac acc cag gag aaa gag cag gtc aag acc ctc aac     1011
 Met Gln Gly Met His Thr Gln Glu Lys Glu Gln Val Lys Thr Leu Asn
 155                 160                 165                 170

 aag tct gcc tcc ttc gtt gac aag gta ctg ttc ctg gaa cag cag aac     1059
 Lys Ser Ala Ser Phe Val Asp Lys Val Leu Phe Leu Glu Gln Gln Asn
                 175                 180                 185

 aag atg ctg gag acc aac tgg agc ctc ctg cag cag cag aag ccg gct     1107
 Lys Met Leu Glu Thr Asn Trp Ser Leu Leu Gln Gln Gln Lys Pro Ala
             190                 195                 200

 cag agc aac atg gac aac atg ttc gag agc tac atc aac aac ctt ctg     1155
 Gln Ser Asn Met Asp Asn Met Phe Glu Ser Tyr Ile Asn Asn Leu Leu
         205                 210                 215

 ggg cag cta gag atc ctg ggc cag gag aag ctg aaa ctg gag gca gag     1203
 Gly Gln Leu Glu Ile Leu Gly Gln Glu Lys Leu Lys Leu Glu Ala Glu
     220                 225                 230

 ctt ggc aac atg cag ggg ctc tgc atg ttt ttc gtg aag gag gac ttc     1251
 Leu Gly Asn Met Gln Gly Leu Cys Met Phe Phe Val Lys Glu Asp Phe
 235                 240                 245                 250

 aag aaa aag tac gag gac gag atc aat aag cct aca gag atg gag aat     1299
 Lys Lys Lys Tyr Glu Asp Glu Ile Asn Lys Pro Thr Glu Met Glu Asn
                 255                 260                 265

 gaa ttt gtc ctc atc aag aag gat gtg gat gac gct tac atg aac aag     1347
 Glu Phe Val Leu Ile Lys Lys Asp Val Asp Asp Ala Tyr Met Asn Lys
             270                 275                 280

 gta gag cta gag ttt cgc ctg gag ggg ctg act gac gag atc aac ttc     1395
 Val Glu Leu Glu Phe Arg Leu Glu Gly Leu Thr Asp Glu Ile Asn Phe
         285                 290                 295

 ctc agg cag ctg tat gaa gag gag atc cca gag ctg cag tcc cag atc     1443
 Leu Arg Gln Leu Tyr Glu Glu Glu Ile Pro Glu Leu Gln Ser Gln Ile
     300                 305                 310

 ttg gac aca tct gtg gtg ctg tcc atg gac aac agc cgc tcc ctg gac     1491
 Leu Asp Thr Ser Val Val Leu Ser Met Asp Asn Ser Arg Ser Leu Asp
 315                 320                 325                 330

 atg gac agc atc atc gcg gag atc aag tat gag gag ctg cag aca ctg     1539
 Met Asp Ser Ile Ile Ala Glu Ile Lys Tyr Glu Glu Leu Gln Thr Leu
                 335                 340                 345

 gct ggg aag cac tgg gat gac cgg cgt ctt aca aag acg aag att tct     1587
 Ala Gly Lys His Trp Asp Asp Arg Arg Leu Thr Lys Thr Lys Ile Ser
             350                 355                 360

 gag atg aac cgg aac atc agc cgg ctc cag gct gag att gag ggc ctg     1635
 Glu Met Asn Arg Asn Ile Ser Arg Leu Gln Ala Glu Ile Glu Gly Leu
         365                 370                 375

 cct caa agg cca gag cag aga gct tcc ctg gag tcc gtc atc gca gat     1683
 Pro Gln Arg Pro Glu Gln Arg Ala Ser Leu Glu Ser Val Ile Ala Asp
     380                 385                 390

 gct gag cag cgg ggg gag ctg gcc att aag gac gcc aag act aag ctg     1731
 Ala Glu Gln Arg Gly Glu Leu Ala Ile Lys Asp Ala Lys Thr Lys Leu
 395                 400                 405                 410

 tcc gag ctg gag gcc gcc cag cag cgg gcc aag cag gac atg gca cat     1779
 Ser Glu Leu Glu Ala Ala Gln Gln Arg Ala Lys Gln Asp Met Ala His
                 415                 420                 425

 ggc acg gca gct gcc tga                                             1797
 Gly Thr Ala Ala Ala 
             430





      <210> 65
      <211> 756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(455)

      <400> 65
 tctcgtcttc ctctgcgccc cgcgtccccg ccctcgcgac cccggctctc ctggactcgg     60

 cgccgccaac ctgggcg   atg ccc cgc tac gag ttg gct ttg att ctg aaa     110
                      Met Pro Arg Tyr Glu Leu Ala Leu Ile Leu Lys
                        1               5                  10

 gcc atg cgg cgg cca gag acc gct gct gct ttg aaa cgt aca ata gaa      158
 Ala Met Arg Arg Pro Glu Thr Ala Ala Ala Leu Lys Arg Thr Ile Glu
              15                  20                  25

 tcc ctg atg gac cga gga gcc ata gtg agg aac ttg gaa agc ctg ggt      206
 Ser Leu Met Asp Arg Gly Ala Ile Val Arg Asn Leu Glu Ser Leu Gly
          30                  35                  40

 gag cgt gcg ctc ccc tac agg atc tcg agt cac agc cag cag cac agc      254
 Glu Arg Ala Leu Pro Tyr Arg Ile Ser Ser His Ser Gln Gln His Ser
      45                  50                  55

 cga gga ggg tat ttc ctg gtg gat ttt tat gct ccg aca agt gct gtg      302
 Arg Gly Gly Tyr Phe Leu Val Asp Phe Tyr Ala Pro Thr Ser Ala Val
  60                  65                  70                  75

 gag aac ata ctg gaa cac ttg gcg cga gac att gac gtg gtt aga cca      350
 Glu Asn Ile Leu Glu His Leu Ala Arg Asp Ile Asp Val Val Arg Pro
                  80                  85                  90

 aat att gtg aaa cac cct ctg acc cag gaa gta aaa gag tgt gac ggc      398
 Asn Ile Val Lys His Pro Leu Thr Gln Glu Val Lys Glu Cys Asp Gly
              95                 100                 105

 ata gtc cca gtc cca ctt gaa gaa aaa ctg tat tca aca aag agg agg      446
 Ile Val Pro Val Pro Leu Glu Glu Lys Leu Tyr Ser Thr Lys Arg Arg
         110                 115                 120

 aag aag tga gaagatt caccagattc tggccttata tttaatccta agggcactat      502
 Lys Lys 
     125

 gggtgctgct aggttgttgt ctaggatact ttagcccatg accattttgc tgcaggaggt    562

 agaaactgct ggccgagacc tgccctgatg tctctgctga gatttcatcc cacttgtggg    622

 gtttgtcggg agtgggggtg ttcacagtac cactgtagcg tttccaagag caaaatgttt    682

 gtcattcaca cttggttgtc ttgcaagcct atatggaaca ctgggagcag agtaataaac    742

 atgactttat caac                                                      756




      <210> 66
      <211> 1662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (158)..(1288)

      <400> 66
 cgcctgcacc tgaattcccg ggtcgacgat ttcgtgcccg ccggccaagc gagcgcgggc     60

 cggggccggg gccggggcct gggggcgccg cccccgggag tctttctgcg gcccctgagg    120

 agcgagggcg acggcgaggc tgaccggggc cgaaacc atg aac cga agt ttt cac     175
                                          Met Asn Arg Ser Phe His
                                            1               5

 aag tct cag acc ttg cga ttc tac gat tgc agc gca gtg gaa gtc aag      223
 Lys Ser Gln Thr Leu Arg Phe Tyr Asp Cys Ser Ala Val Glu Val Lys
              10                  15                  20

 agc aag ttt ggg gcg gaa ttc cga agg ttc tct ctg gac cgt cat aag      271
 Ser Lys Phe Gly Ala Glu Phe Arg Arg Phe Ser Leu Asp Arg His Lys
          25                  30                  35

 cct ggg aag ttt gaa gat ttc tac aag ctg gtt gtg cac acc cac cat      319
 Pro Gly Lys Phe Glu Asp Phe Tyr Lys Leu Val Val His Thr His His
      40                  45                  50

 atc tcc aac agt gat gta act att ggc tat gca gat gtg cac gga gac      367
 Ile Ser Asn Ser Asp Val Thr Ile Gly Tyr Ala Asp Val His Gly Asp
  55                  60                  65                  70

 ctg ctg ccc atc aac aat gat gac aac ttc tgc aag gcg gtt tct agt      415
 Leu Leu Pro Ile Asn Asn Asp Asp Asn Phe Cys Lys Ala Val Ser Ser
                  75                  80                  85

 gca aat ccc ctg ctc agg gtc ttc atc cag aaa cga gag gag gcc gag      463
 Ala Asn Pro Leu Leu Arg Val Phe Ile Gln Lys Arg Glu Glu Ala Glu
              90                  95                 100

 cgt ggc agc ctc ggc gcg ggc tcg ctg tgc agg cgg agg cgg gcg ctg      511
 Arg Gly Ser Leu Gly Ala Gly Ser Leu Cys Arg Arg Arg Arg Ala Leu
         105                 110                 115

 ggc gcg ctg cgt gat gaa gga ccc cgg cgg cgt gca cac ctg gac atc      559
 Gly Ala Leu Arg Asp Glu Gly Pro Arg Arg Arg Ala His Leu Asp Ile
     120                 125                 130

 ggc ctc ccg cgc gac ttc cgc ccc gta tca tcc atc atc gat gtg gac      607
 Gly Leu Pro Arg Asp Phe Arg Pro Val Ser Ser Ile Ile Asp Val Asp
 135                 140                 145                 150

 ctg gtc ccc gag acg cac cgg cga gtg cgg ctg cac cgg cac ggc tgc      655
 Leu Val Pro Glu Thr His Arg Arg Val Arg Leu His Arg His Gly Cys
                 155                 160                 165

 gag aag ccg ctg ggc ttc tac atc cgc gat ggc gcc agc gtg cgc gtg      703
 Glu Lys Pro Leu Gly Phe Tyr Ile Arg Asp Gly Ala Ser Val Arg Val
             170                 175                 180

 acc ccg cac ggg ctg gag aag gtg ccc ggc atc ttc atc tcg cgc atg      751
 Thr Pro His Gly Leu Glu Lys Val Pro Gly Ile Phe Ile Ser Arg Met
         185                 190                 195

 gta ccc ggg ggc ctg gcg gag agc acc ggg ctg ctg gct gtg aat gac      799
 Val Pro Gly Gly Leu Ala Glu Ser Thr Gly Leu Leu Ala Val Asn Asp
     200                 205                 210

 gag gtc ctg gag gtg aac ggc att gag gtg gcc ggg aag acg ctg gac      847
 Glu Val Leu Glu Val Asn Gly Ile Glu Val Ala Gly Lys Thr Leu Asp
 215                 220                 225                 230

 cag gtc acg gac atg atg atc gcc aac agc cac aac ctc atc gtc acc      895
 Gln Val Thr Asp Met Met Ile Ala Asn Ser His Asn Leu Ile Val Thr
                 235                 240                 245

 gtc aag ccc gcc aac cag cgc aac aac gtg gtg cgc ggc ggc cgc gcg      943
 Val Lys Pro Ala Asn Gln Arg Asn Asn Val Val Arg Gly Gly Arg Ala
             250                 255                 260

 ttg ggc agc tcg gga ccg ccc tcg gac ggc acc gcg ggc ttc gtg ggt      991
 Leu Gly Ser Ser Gly Pro Pro Ser Asp Gly Thr Ala Gly Phe Val Gly
         265                 270                 275

 ccc ccc gcc ccg cgc gtc ctg cag aac ttc cac ccc gac gag gcg gag     1039
 Pro Pro Ala Pro Arg Val Leu Gln Asn Phe His Pro Asp Glu Ala Glu
     280                 285                 290

 agc gat gag gac aac gac gtc gtc atc gag ggc aca ctg gag cct gca     1087
 Ser Asp Glu Asp Asn Asp Val Val Ile Glu Gly Thr Leu Glu Pro Ala
 295                 300                 305                 310

 cgt ccc ccc cag acc ccg ggc gcg ccc gca ggc agc ctc tcc cgg gtc     1135
 Arg Pro Pro Gln Thr Pro Gly Ala Pro Ala Gly Ser Leu Ser Arg Val
                 315                 320                 325

 aat ggc gcg ggc ctg gcg cag cgg ctg cag cgg gac ctg gcc ctg gac     1183
 Asn Gly Ala Gly Leu Ala Gln Arg Leu Gln Arg Asp Leu Ala Leu Asp
             330                 335                 340

 ggc ggc ctc cag cgg ctg ctc agc tcc ctg cgg gcc gac ccc cgt cac     1231
 Gly Gly Leu Gln Arg Leu Leu Ser Ser Leu Arg Ala Asp Pro Arg His
         345                 350                 355

 agc ctg gcg ctg ccg cca ggc ggc gtg gag gag cac ggg ccc gcg gtc     1279
 Ser Leu Ala Leu Pro Pro Gly Gly Val Glu Glu His Gly Pro Ala Val
     360                 365                 370

 acg ctc tag actcccg agaggccccc aaatcctagc tccagttccc cggtaaggac     1335
 Thr Leu 
 375

 agggacagga cctgcagact gcatccgctc attttttgtt gtttttgtga ccacaaaaac   1395

 aacgctgctc tttgtttcaa cttccggata taaaaacaca agtattgcct atttttatag   1455

 aatttcgcca cagaacttaa aatgaacgcc tgtagagaca ctctatacca ggcctgagtg   1515

 caggtcttgg cgcctttgca aagtgataga aaagatctga ccaagtgcta aaaaatgctt   1575

 tttaaaattt ttacaaatac tttgttttta aagtgaagct tttaaattac ttttttaaaa   1635

 tagtccaatt catgttttta agtaaga                                       1662




      <210> 67
      <211> 1120
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (387)..(899)

      <400> 67
 ctggtgacct tgttgcagat gtgggttgtc cccttatatt tcacgataaa attatactgg     60

 tggcggtttc tgtctatgtg ggggatgttc tccgttatta ccagttacat cctcttcaga    120

 gctacccgaa aacccctctc aggaaggaca ccacgttcac ccctgcccac tcccccacgc    180

 agctcacccc tgcccgctcc cccacgcagc tcacccctgc ccgctccccc acgcagccta    240

 cccctgcccg ctcccccacg cagctcaccc ctgcccgctc ccccacacag ctcacccctg    300

 cccgctcccc cacattggtc tacaaatggt ttcttttgat ctacaaactc agctatgcat    360

 ttggtgttgt gggttacttg gcgatc atg ttt aca atg tgt gga ttc aat ctg     413
                              Met Phe Thr Met Cys Gly Phe Asn Leu
                                1               5

 ttt ttc aaa atc aaa gct aga gat tcc atg gat ttt ggc att gtg tct      461
 Phe Phe Lys Ile Lys Ala Arg Asp Ser Met Asp Phe Gly Ile Val Ser
  10                  15                  20                  25

 ttg ttc tac ggc ctc tac tat gga gta atg ggg aga gac ttt gcc gag      509
 Leu Phe Tyr Gly Leu Tyr Tyr Gly Val Met Gly Arg Asp Phe Ala Glu
                  30                  35                  40

 atc tgc tca gac tac atg gct tcc act ata ggg ttc tac agt gtc agc      557
 Ile Cys Ser Asp Tyr Met Ala Ser Thr Ile Gly Phe Tyr Ser Val Ser
              45                  50                  55

 cgg ttg cct aca agg agc tta tcg gac aat atc tgt gca gtc tgt ggg      605
 Arg Leu Pro Thr Arg Ser Leu Ser Asp Asn Ile Cys Ala Val Cys Gly
          60                  65                  70

 cag aag atc att gtg gag ctt gat gaa gaa ggg ctc att gaa aac acc      653
 Gln Lys Ile Ile Val Glu Leu Asp Glu Glu Gly Leu Ile Glu Asn Thr
      75                  80                  85

 tac cag ctt tcc tgt aat cat gtc ttt cat gaa ttc tgc atc cga ggt      701
 Tyr Gln Leu Ser Cys Asn His Val Phe His Glu Phe Cys Ile Arg Gly
  90                  95                 100                 105

 tgg tgt atc gtt ggg aaa aag cag act tgc cct tac tgc aaa gag aaa      749
 Trp Cys Ile Val Gly Lys Lys Gln Thr Cys Pro Tyr Cys Lys Glu Lys
                 110                 115                 120

 gtt gat ttg aag agg atg atc agt aat ccc tgg gag cgc aca cat ttt      797
 Val Asp Leu Lys Arg Met Ile Ser Asn Pro Trp Glu Arg Thr His Phe
             125                 130                 135

 ctg tat gga caa atc ctg gat tgg ctt cgt tat ttg gtg gcc tgg caa      845
 Leu Tyr Gly Gln Ile Leu Asp Trp Leu Arg Tyr Leu Val Ala Trp Gln
         140                 145                 150

 cct gtg gtg ata gga ata gtt caa ggc att aac tat tca cta ggg ctg      893
 Pro Val Val Ile Gly Ile Val Gln Gly Ile Asn Tyr Ser Leu Gly Leu
     155                 160                 165

 gaa tag gacagcagac cccagaagca acatactgca tggttgaaat ccttggtcca       949
 Glu 
 170

 acatttaata ttaatttttt taattttaga gatgatccca agtgtttaga aaactaagta   1009

 aactttgttg tcaagcaatt tgtccatgtg gaaagaattt aaagagaagc tgaacaatgg   1069

 aataaacaaa taaagcatgt tttttcatct ttcccattaa aaaaaaaaaa a            1120




      <210> 68
      <211> 1254
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (343)..(1254)

      <400> 68
 cagagcaagc ccctgtctca aataaaataa aataaaataa aatataaaat aggaatgcta     60

 tgtggttgta gcagatgaaa gtgctgtttg tgtattaggt taaaatgggt aaatattagc    120

 aatttcatat acttcaacct aaagggcacc tacccctaag gttgttacaa ggattcagtg    180

 aaataaggga accagttcac ctaggaatta agaacacagt ctctgggctg ctgtccacct    240

 ggcaagggag tcccatctgt ccagattgtc ccagatcttg ctgcccgccc agtggccgaa    300

 gtccttcagg tctggaggtc gtggtgtcac agtctccatg ac   atg ttg atg ctg     354
                                                  Met Leu Met Leu
                                                    1

 gct gag cag cag cag aag cag aag tgg gct gtg aat act caa aac act      402
 Ala Glu Gln Gln Gln Lys Gln Lys Trp Ala Val Asn Thr Gln Asn Thr
   5                  10                  15                  20

 gcc tgg agt aat gct gat tct aaa ttt ggc cag agg ata cta gag aag      450
 Ala Trp Ser Asn Ala Asp Ser Lys Phe Gly Gln Arg Ile Leu Glu Lys
                  25                  30                  35

 atg gaa tgg tct aaa gga agg ggt tta ggg gtt cag gag caa gga ggc      498
 Met Glu Trp Ser Lys Gly Arg Gly Leu Gly Val Gln Glu Gln Gly Gly
              40                  45                  50

 cca gat gat att aaa gtt caa gtt aaa aat aac gac ctg gga ctt caa      546
 Pro Asp Asp Ile Lys Val Gln Val Lys Asn Asn Asp Leu Gly Leu Gln
          55                  60                  65

 gct aca atc aat aat gaa gcc aac tgg att gcc cat caa gat gat ttt      594
 Ala Thr Ile Asn Asn Glu Ala Asn Trp Ile Ala His Gln Asp Asp Phe
      70                  75                  80

 aac tgg ctt ctg gcg gaa ctg aac act tgt cag agg cag gaa aca gca      642
 Asn Trp Leu Leu Ala Glu Leu Asn Thr Cys Gln Arg Gln Glu Thr Ala
  85                  90                  95                 100

 gac tcc tta gac aac aag aaa aag aaa tat ttt agt ctt gaa gaa att      690
 Asp Ser Leu Asp Asn Lys Lys Lys Lys Tyr Phe Ser Leu Glu Glu Ile
                 105                 110                 115

 cca aaa tct tca aaa act gtg ttc atc ata gga aat tta caa aag aaa      738
 Pro Lys Ser Ser Lys Thr Val Phe Ile Ile Gly Asn Leu Gln Lys Lys
             120                 125                 130

 agg atc tat cat ctc gga gca aaa cag atc gtg act gca ttt ttg gga      786
 Arg Ile Tyr His Leu Gly Ala Lys Gln Ile Val Thr Ala Phe Leu Gly
         135                 140                 145

 aaa aac aga gag cgt ttt gcc aag cga atg gca gca ctg aag aac aag      834
 Lys Asn Arg Glu Arg Phe Ala Lys Arg Met Ala Ala Leu Lys Asn Lys
     150                 155                 160

 ccc cag gtt gca gct cca ggg cct gac att tcc aag acc caa gtg gaa      882
 Pro Gln Val Ala Ala Pro Gly Pro Asp Ile Ser Lys Thr Gln Val Glu
 165                 170                 175                 180

 tgc aaa agg ggg aag aaa aga aac aaa gag gca aca ggt aaa aat ggg      930
 Cys Lys Arg Gly Lys Lys Arg Asn Lys Glu Ala Thr Gly Lys Asn Gly
                 185                 190                 195

 gag agt tac ccc cca aca cag cct aag gcc aag cgg cct aaa gag gga      978
 Glu Ser Tyr Pro Pro Thr Gln Pro Lys Ala Lys Arg Pro Lys Glu Gly
             200                 205                 210

 aag cct aag aga gac aag gtc cag aag tcg gca tcc aag gag aaa aga     1026
 Lys Pro Lys Arg Asp Lys Val Gln Lys Ser Ala Ser Lys Glu Lys Arg
         215                 220                 225

 gca cgg aca gac gga cag tgc aga ggc ctc tgc tgg gaa gag agt tct     1074
 Ala Arg Thr Asp Gly Gln Cys Arg Gly Leu Cys Trp Glu Glu Ser Ser
     230                 235                 240

 gag gcc tct gct cag ggt gca ggg aat tgt gtg cag cca cct gat ggc     1122
 Glu Ala Ser Ala Gln Gly Ala Gly Asn Cys Val Gln Pro Pro Asp Gly
 245                 250                 255                 260

 cag gat ttc acc ctg aag ccc aaa aag aca aga gga aaa aaa aaa gct     1170
 Gln Asp Phe Thr Leu Lys Pro Lys Lys Thr Arg Gly Lys Lys Lys Ala
                 265                 270                 275

 gca aag cca gta gag gta gca atg gac act acg ctg aaa gaa aca cca     1218
 Ala Lys Pro Val Glu Val Ala Met Asp Thr Thr Leu Lys Glu Thr Pro
             280                 285                 290

 atg aaa aat aag aaa aag aag aaa ggt tcc aaa tga                     1254
 Met Lys Asn Lys Lys Lys Lys Lys Gly Ser Lys 
         295                 300





      <210> 69
      <211> 536
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (17)..(493)

      <400> 69
 tcaatccgcc agaatc    atg ggc tgc tgt ggc tgt tct gga ggc tgt ggc      49
                      Met Gly Cys Cys Gly Cys Ser Gly Gly Cys Gly
                        1               5                  10

 tct ggc tgt ggg ggc tgt ggc tcc ggc agt ggg ggc tgt ggc tct ggc       97
 Ser Gly Cys Gly Gly Cys Gly Ser Gly Ser Gly Gly Cys Gly Ser Gly
              15                  20                  25

 tgt ggg ggc tgt ggc tcc agc tgc tgt gtg ccc att tgc tgc tgc aag      145
 Cys Gly Gly Cys Gly Ser Ser Cys Cys Val Pro Ile Cys Cys Cys Lys
          30                  35                  40

 cct gtg tgc tgc tgt gtg cca gcc tgt tcc tgc tcc agc tgt ggc tcc      193
 Pro Val Cys Cys Cys Val Pro Ala Cys Ser Cys Ser Ser Cys Gly Ser
      45                  50                  55

 tgt ggg ggc tcc aaa ggg ggc tgt ggc tct tgt ggg agc tcc aag ggt      241
 Cys Gly Gly Ser Lys Gly Gly Cys Gly Ser Cys Gly Ser Ser Lys Gly
  60                  65                  70                  75

 ggg tgt ggt tct tgt ggc tgc tcc cag tcc aac tgc tgt aag ccc tgc      289
 Gly Cys Gly Ser Cys Gly Cys Ser Gln Ser Asn Cys Cys Lys Pro Cys
                  80                  85                  90

 tgc tcc tcc tca ggc tgt ggg tca ttc tgc tgc cag tcc agc tgc tcc      337
 Cys Ser Ser Ser Gly Cys Gly Ser Phe Cys Cys Gln Ser Ser Cys Ser
              95                 100                 105

 aaa ccc tgc tgc tgc caa tcc agc tgc tgc cag tcc agc tgc tgc aag      385
 Lys Pro Cys Cys Cys Gln Ser Ser Cys Cys Gln Ser Ser Cys Cys Lys
         110                 115                 120

 ccc tgc tgc tgc caa tcc agc tgc tgc cag tct agc tgc ttc aag ccc      433
 Pro Cys Cys Cys Gln Ser Ser Cys Cys Gln Ser Ser Cys Phe Lys Pro
     125                 130                 135

 tgc tgc tgc cag tcc agc tgc tgt gtc ccc gtg tgc ttc agg ttt ctc      481
 Cys Cys Cys Gln Ser Ser Cys Cys Val Pro Val Cys Phe Arg Phe Leu
 140                 145                 150                 155

 ctc att tgg tga aag catttcttat ggtttctctg aatcagttca tcccacacat      536
 Leu Ile Trp 






      <210> 70
      <211> 4819
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(2324)

      <400> 70
 catgccacct gcttctggcg ccccgctgga ccctgcttcg aagggaccgt ttggtcgcca     60

 gagggcggtt cctggagtta cagccgcgtt tgcgggacgt gtctgcgcgg cagtcctggc    120

 ctgttgagct tgtccagacg aagcctcgca gggatgggtt ggagcccggg ccgggcttcg    180

 ctcaggcagc gtttgaggca gacccagcag ggtcctcctg gggccttcct gcctttgaac    240

 tgcggtggcg ggcgggcgca cggtctcctg tacgccctag actaggggcc gccatctcc     299                                                                 
 atg gcc acg gcc gtg agc cgg ccc tgc gcc ggc agg tcg cgg gac ata      347
 Met Ala Thr Ala Val Ser Arg Pro Cys Ala Gly Arg Ser Arg Asp Ile
   1               5                  10                  15

 ctg tgg cgc gtt ttg ggc tgg agg ata gtt gca agt att gtt tgg tca      395
 Leu Trp Arg Val Leu Gly Trp Arg Ile Val Ala Ser Ile Val Trp Ser
              20                  25                  30

 gtg cta ttt cta ccc atc tgc acc aca gta ttt ata att ttc agc agg      443
 Val Leu Phe Leu Pro Ile Cys Thr Thr Val Phe Ile Ile Phe Ser Arg
          35                  40                  45

 att gat ttg ttt cat cct ata cag tgg ctg tct gat tct ttc agt gac      491
 Ile Asp Leu Phe His Pro Ile Gln Trp Leu Ser Asp Ser Phe Ser Asp
      50                  55                  60

 ctg tat agt tcc tat gta atc ttt tac ttc ctg ctg ctg tca gtg gta      539
 Leu Tyr Ser Ser Tyr Val Ile Phe Tyr Phe Leu Leu Leu Ser Val Val
  65                  70                  75                  80

 ata ata ata ata agt att ttc aat gtg gag ttc tat gca gtt gtg cct      587
 Ile Ile Ile Ile Ser Ile Phe Asn Val Glu Phe Tyr Ala Val Val Pro
                  85                  90                  95

 tct att cct tgc tcc aga cta gct ctg ata ggg aag atc att cat cct      635
 Ser Ile Pro Cys Ser Arg Leu Ala Leu Ile Gly Lys Ile Ile His Pro
             100                 105                 110

 cag caa ctc atg cac tca ttt att cat gct gca atg gga atg gtg atg      683
 Gln Gln Leu Met His Ser Phe Ile His Ala Ala Met Gly Met Val Met
         115                 120                 125

 gcc tgg tgt gct gca gtg ata acc cag ggc cag tac agc ttt ctt gtg      731
 Ala Trp Cys Ala Ala Val Ile Thr Gln Gly Gln Tyr Ser Phe Leu Val
     130                 135                 140

 gtt ccc tgc act ggt act aac agc ttt ggt agc cct gct gcg caa acc      779
 Val Pro Cys Thr Gly Thr Asn Ser Phe Gly Ser Pro Ala Ala Gln Thr
 145                 150                 155                 160

 tgc tta aat gaa tat cat ctt ttt ttc cta ctg act gga gca ttt atg      827
 Cys Leu Asn Glu Tyr His Leu Phe Phe Leu Leu Thr Gly Ala Phe Met
                 165                 170                 175

 ggc tat agc tat agc ctc ctg tat ttt gtt aac aac atg aac tat ctt      875
 Gly Tyr Ser Tyr Ser Leu Leu Tyr Phe Val Asn Asn Met Asn Tyr Leu
             180                 185                 190

 cca ttt ccc atc ata cag caa tac aag ttc ttg cgt ttt agg aga tct      923
 Pro Phe Pro Ile Ile Gln Gln Tyr Lys Phe Leu Arg Phe Arg Arg Ser
         195                 200                 205

 ctg ctc tta tta gtt aaa cac agt tgt gtg gaa tca ctg ttc ctg gtt      971
 Leu Leu Leu Leu Val Lys His Ser Cys Val Glu Ser Leu Phe Leu Val
     210                 215                 220

 aga aat ttc tgc att tta tat tat ttt ctt ggc tat att ccc aaa gct     1019
 Arg Asn Phe Cys Ile Leu Tyr Tyr Phe Leu Gly Tyr Ile Pro Lys Ala
 225                 230                 235                 240

 tgg att agc act gct atg aac ctt cac ata gat gag cag gtt cat agg     1067
 Trp Ile Ser Thr Ala Met Asn Leu His Ile Asp Glu Gln Val His Arg
                 245                 250                 255

 cca ctt gac aca gtg agt ggc ctc tta aat ctc tcg tta ctc tac cat     1115
 Pro Leu Asp Thr Val Ser Gly Leu Leu Asn Leu Ser Leu Leu Tyr His
             260                 265                 270

 gtc tgg ctg tgt ggt gtc ttt ctc ctg acg act tgg tat gtc tca tgg     1163
 Val Trp Leu Cys Gly Val Phe Leu Leu Thr Thr Trp Tyr Val Ser Trp
         275                 280                 285

 ata ctc ttc aaa atc tat gcc aca gag gct cat gtg ttt cct gtt caa     1211
 Ile Leu Phe Lys Ile Tyr Ala Thr Glu Ala His Val Phe Pro Val Gln
     290                 295                 300

 cca cca ttt gca gaa ggg tca gat gag tgc ctt cca aaa gtg tta aat     1259
 Pro Pro Phe Ala Glu Gly Ser Asp Glu Cys Leu Pro Lys Val Leu Asn
 305                 310                 315                 320

 agc aat cct ccc ccc atc ata aag tat tta gcc ttg cag gac ctg atg     1307
 Ser Asn Pro Pro Pro Ile Ile Lys Tyr Leu Ala Leu Gln Asp Leu Met
                 325                 330                 335

 ttg ctt tct caa tat tct cct tca cga aga caa gaa gtt ttc agc ctc     1355
 Leu Leu Ser Gln Tyr Ser Pro Ser Arg Arg Gln Glu Val Phe Ser Leu
             340                 345                 350

 agc caa cca ggt gga cat ccc cac aat tgg aca gcc att tca agg gag     1403
 Ser Gln Pro Gly Gly His Pro His Asn Trp Thr Ala Ile Ser Arg Glu
         355                 360                 365

 tgt ttg aat ctt tta aat ggt atg act cag aaa ctg att ctc tat caa     1451
 Cys Leu Asn Leu Leu Asn Gly Met Thr Gln Lys Leu Ile Leu Tyr Gln
     370                 375                 380

 gaa gct gct gct acg aat ggg aga gtg tct tca tct tac cca gtg gaa     1499
 Glu Ala Ala Ala Thr Asn Gly Arg Val Ser Ser Ser Tyr Pro Val Glu
 385                 390                 395                 400

 cct aag aaa tta aat tct cca gaa gaa act gct ttt cag aca cca aaa     1547
 Pro Lys Lys Leu Asn Ser Pro Glu Glu Thr Ala Phe Gln Thr Pro Lys
                 405                 410                 415

 tct agc cag atg cct cgg cct tca gtg cca cca tta gtt aaa aca tca     1595
 Ser Ser Gln Met Pro Arg Pro Ser Val Pro Pro Leu Val Lys Thr Ser
             420                 425                 430

 ctg ttt tct tca aaa tta tct aca cct gat gtt gtg agc cca ttt ggg     1643
 Leu Phe Ser Ser Lys Leu Ser Thr Pro Asp Val Val Ser Pro Phe Gly
         435                 440                 445

 acc cca ttt ggc tct agt gta atg aat cgg atg gct gga att ttt gat     1691
 Thr Pro Phe Gly Ser Ser Val Met Asn Arg Met Ala Gly Ile Phe Asp
     450                 455                 460

 gta aac acc tgc tat ggg tca ccg caa agt cct cag cta ata aga agg     1739
 Val Asn Thr Cys Tyr Gly Ser Pro Gln Ser Pro Gln Leu Ile Arg Arg
 465                 470                 475                 480

 ggg cca aga ttg tgg aca tca gct tct gat cag caa atg act gaa ttt     1787
 Gly Pro Arg Leu Trp Thr Ser Ala Ser Asp Gln Gln Met Thr Glu Phe
                 485                 490                 495

 tct aat cct tct cca tct acc tct att agt gct gag ggt aag aca atg     1835
 Ser Asn Pro Ser Pro Ser Thr Ser Ile Ser Ala Glu Gly Lys Thr Met
             500                 505                 510

 aga caa ccc agt gtg att tat tca tgg att cag aat aaa cgt gaa cag     1883
 Arg Gln Pro Ser Val Ile Tyr Ser Trp Ile Gln Asn Lys Arg Glu Gln
         515                 520                 525

 att aag aat ttc ttg tca aaa cgg gtg ctg ata atg tat ttt ttc agt     1931
 Ile Lys Asn Phe Leu Ser Lys Arg Val Leu Ile Met Tyr Phe Phe Ser
     530                 535                 540

 aag cac cca gag gcc tcc att cag gct gtt ttt tca gat gcc caa atg     1979
 Lys His Pro Glu Ala Ser Ile Gln Ala Val Phe Ser Asp Ala Gln Met
 545                 550                 555                 560

 cat att tgg gca tta gaa ggt ctg tcg cac tta gta gca gca tca ttt     2027
 His Ile Trp Ala Leu Glu Gly Leu Ser His Leu Val Ala Ala Ser Phe
                 565                 570                 575

 aca gag gat aga ttt gga gtt gtc cag acg aca cta cca gct atc ctt     2075
 Thr Glu Asp Arg Phe Gly Val Val Gln Thr Thr Leu Pro Ala Ile Leu
             580                 585                 590

 aat act ttg ttg aca ctg caa gag gca gtc gac aag tac ttt aag ctt     2123
 Asn Thr Leu Leu Thr Leu Gln Glu Ala Val Asp Lys Tyr Phe Lys Leu
         595                 600                 605

 cct cat gct tcc agt aaa cca ccc cgg att tca gga agc ctt gtg gac     2171
 Pro His Ala Ser Ser Lys Pro Pro Arg Ile Ser Gly Ser Leu Val Asp
     610                 615                 620

 act tca tat aaa aca tta aga ttt gca ttc aga gca tca ctg aaa act     2219
 Thr Ser Tyr Lys Thr Leu Arg Phe Ala Phe Arg Ala Ser Leu Lys Thr
 625                 630                 635                 640

 gcc atc tat cga ata act act aca ttt ggt gaa cat ctg aat gct gtg     2267
 Ala Ile Tyr Arg Ile Thr Thr Thr Phe Gly Glu His Leu Asn Ala Val
                 645                 650                 655

 caa gca tct gca gaa cat cag aaa aga ctt caa cag ttc ttg gag ttc     2315
 Gln Ala Ser Ala Glu His Gln Lys Arg Leu Gln Gln Phe Leu Glu Phe
             660                 665                 670

 aaa gaa tag ttaagta atataaactg tgttcattac actgctgata caactacaga     2371
 Lys Glu 


 tgggacagta aatgttcagc attcttggat cagaagaaaa cggactaatt agatgcttcc   2431

 tttgtcgtgg tggttgcttt gaaaactata ctttaatggg agaaatcatg gaaagaaatt   2491

 ctcaacagaa taactgaaaa ctgccttttc tgtaccgatt gctttttgtg tgtgtggtat   2551

 aataaaatct ttattcaatt ttacagaagc attgatggca gtcgaaatgt ctctagctca   2611

 tataacttaa tagtaataac taaaaaactt ttagaattta cttttgaaag gagggaagcc   2671

 agttctgaaa tgagtatagg ttgatttcat agtcttctta attaagagtt tagctctttg   2731

 taaactcaaa atacataaac tttttaagtg tagtttcatt tactgaagga taaaaatggt   2791

 aacagtgcag caatattcac aaaaaatatt gtctaacgga catattttgt taatctgtta   2851

 ggttgggttt ttgtttccag ggacaaatta aatttgtatg attacccaaa aaagggtctc   2911

 agtttacaga tgctaactct atataaagga atgtggaaaa actcagttct taagttacaa   2971

 gattaaaaat tcacatttgg tctttaagaa acaattgact gacatctatg aatttatttt   3031

 gtatcatgct agtaaacacg aagtattaat gtatgggtat tttcccagct agttttgctt   3091

 tctttttctg gagcaaaaca ttaagtgatt gcagagtttt tcaagcaaga gaaaaaggtt   3151

 tgcaaaaaaa cccaggaaat gttccctttt ttccccacca ttcatcttca ttagatcaaa   3211

 ttctgtgaaa cttgtctggt ctctcaaagg gagcagcctc tgtagtgtta aatggctaat   3271

 taaaatagga agatctttat agccagaaac aacttagtca tcaaatagca agtgaaacca   3331

 aaacgtcaga gggattactg tacttggaag tatgttgtgt gtcccaaatg tgaacgaagt   3391

 attgttagaa tttattagat cagcttcttt ggagatcaaa gattggaaat cctagtcata   3451

 gatattcact ggactggctt tggactgaaa tgctcctttg taattctttt cctattgtct   3511

 tttccttcta gtgtcccaaa atattttctt taaagtcagc acagtactgt atatgaatct   3571

 ttaatgtggt atcatatatg tctacttttg tctgattcat cgatgtatta tatctttata   3631

 attgaatatt ttagctccgg gtcctgttgc cccttcaagc agtacatgcc aaattataaa   3691

 taggtgctac tggccttgag catatcactg tgggacagtt ccccaattgt caagtgttta   3751

 gatatgtaga ctattgccat ttgttttttt gttttggttt tgctttgtgt ctgaagctga   3811

 attgatttct tttttttgaa tgtgaaagtt gaatttcaaa cgtagtcatt tcttacagat   3871

 ggccaagaca gaaaattgtg gctaggttga ctgagaactg ttgtcttcca tgtattaaca   3931

 caattaagct ttttatattc cactctctgt gctgaccctg gctgaggcat tttgggagac   3991

 aaggactctg aatcttctgc ttccattaaa gaagaactgt gatattcaac attggatttc   4051

 tgagaataaa gataggatga ttcctttgaa ctttgactta cttgtataaa atgtccagct   4111

 aggttaggtt tttgccattt cctatatact ttgggtaaag ctacatttga tgagcaatgt   4171

 gaatgtttct gagaatgttc attcctgttt tctcttaaga gaatgtgctg tgtactaaat   4231

 acaggccaca tagtgtctgc ctgttgaaga tctggaaact gcctccccag atctgtattg   4291

 tatttggtag gtaagggggt cagtttcttt ttctcattgt gtgttgataa tctacacacc   4351

 atctgttgga accagggtgt tattatgggg aactcctcct gtgtactagg aggaggacct   4411

 tagggagacc aagaggagag aagcatttcc tttgatgaag tcacatcctg tctatgagcc   4471

 cactaatgct gtaacattgg cctgaaagag agtgttcttt aaaagccttt ctcggctgtt   4531

 agtataaaaa catgatggta tcagctctta gcatgtttgc ttgaccctta tggaaggtat   4591

 aaatccacag aacttccttc ccagagaact gggaaattgt cctagaaata aaccttgtac   4651

 agttgagtgg acatggataa gcaacaattt gttactttgc aggatttgtt ccttggtaat   4711

 tgtttggtgt gtcatcctgt aaatattcat gatagtctgt ttatatcctt ttgtatatcg   4771

 ttgatactgg attgggtaga aaaataaatt ggcaatttaa aaaaaaaa                4819




      <210> 71
      <211> 1593
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (228)..(1253)

      <400> 71
 gcacgagcag cgagctgccc cggggtctct ccggtttcct aatcagggca acgccgcggg     60

 agagaacctt taccttggct gcactaagtt ctcggtgcca ctccctggca gggcgggacc    120

 ttgtttaggc cctgtgatcg cgcggttcgt agtagcgcaa ggcgcagagt ggaccttgac    180

 ccgcctaggg cgggaagagt ttggcccgcc gggtcccaaa gggcaga  atg gac ggg     236
                                                      Met Asp Gly
                                                        1

 ctc cta aat ccc agg gaa tcc tct aaa ttc att gca gaa aac agt cgg      284
 Leu Leu Asn Pro Arg Glu Ser Ser Lys Phe Ile Ala Glu Asn Ser Arg
       5                  10                  15

 gat gtg ttt att gac agc gga ggc gta cgg agg gtg gca gag ctg ctg      332
 Asp Val Phe Ile Asp Ser Gly Gly Val Arg Arg Val Ala Glu Leu Leu
  20                  25                  30                  35

 ctg gcc aag gcg gcg ggg cca gag ctg cgc gtg gag ggg tgg aaa gcc      380
 Leu Ala Lys Ala Ala Gly Pro Glu Leu Arg Val Glu Gly Trp Lys Ala
                  40                  45                  50

 ctt cat gag ctg aac ccc agg gcg gcc gac gag gcc gcg gtc aac tgg      428
 Leu His Glu Leu Asn Pro Arg Ala Ala Asp Glu Ala Ala Val Asn Trp
              55                  60                  65

 gtg ttc gtg aca gac acg ctc aac ttc tcc ttt tgg tcg gag cag gac      476
 Val Phe Val Thr Asp Thr Leu Asn Phe Ser Phe Trp Ser Glu Gln Asp
          70                  75                  80

 gag cac aag tgt gtg gtg agg tac aga ggg aaa aca tac agt ggg tac      524
 Glu His Lys Cys Val Val Arg Tyr Arg Gly Lys Thr Tyr Ser Gly Tyr
      85                  90                  95

 tgg tcc ctg tgc gcc gcc gtc aac aga gcc ctc gac gaa ggg ata cca      572
 Trp Ser Leu Cys Ala Ala Val Asn Arg Ala Leu Asp Glu Gly Ile Pro
 100                 105                 110                 115

 ata act agt gcc tcg tac tac gcg aca gtg acc ctg gat cag gtt cgg      620
 Ile Thr Ser Ala Ser Tyr Tyr Ala Thr Val Thr Leu Asp Gln Val Arg
                 120                 125                 130

 aat ata ctt cgt tct gac aca gac gtt tcc atg cct tta gta gaa gag      668
 Asn Ile Leu Arg Ser Asp Thr Asp Val Ser Met Pro Leu Val Glu Glu
             135                 140                 145

 agg cat cgg att ctc aat gaa acc ggg aaa att ctg ctg gag aag ttt      716
 Arg His Arg Ile Leu Asn Glu Thr Gly Lys Ile Leu Leu Glu Lys Phe
         150                 155                 160

 gga ggc tct ttt ctc aac tgc gtc cga gaa agt gag aat agt gcg cag      764
 Gly Gly Ser Phe Leu Asn Cys Val Arg Glu Ser Glu Asn Ser Ala Gln
     165                 170                 175

 aag tta atg cac ctg gtg gtt gaa agt ttt cct tct tac aga gat gtg      812
 Lys Leu Met His Leu Val Val Glu Ser Phe Pro Ser Tyr Arg Asp Val
 180                 185                 190                 195

 act ctg ttt gag ggg aaa aga gtt tct ttt tac aaa cga gcc caa atc      860
 Thr Leu Phe Glu Gly Lys Arg Val Ser Phe Tyr Lys Arg Ala Gln Ile
                 200                 205                 210

 ctt gta gca gat acg tgg agt gta ttg gaa gga aaa gga gat ggc tgc      908
 Leu Val Ala Asp Thr Trp Ser Val Leu Glu Gly Lys Gly Asp Gly Cys
             215                 220                 225

 ttc aag gac atc tcc agt atc acc atg ttt gct gat tat aga tta cct      956
 Phe Lys Asp Ile Ser Ser Ile Thr Met Phe Ala Asp Tyr Arg Leu Pro
         230                 235                 240

 cag gtt ctt gct cat ctt gga gcc ctg aaa tac tct gat gac cta ctg     1004
 Gln Val Leu Ala His Leu Gly Ala Leu Lys Tyr Ser Asp Asp Leu Leu
     245                 250                 255

 aag aag ctt ctc aaa gga gaa atg ctc tca tat gga gac agg caa gag     1052
 Lys Lys Leu Leu Lys Gly Glu Met Leu Ser Tyr Gly Asp Arg Gln Glu
 260                 265                 270                 275

 gtg gaa atc aga ggg tgc tcg ctt tgg tgt gtt gag ctg atc cgg gat     1100
 Val Glu Ile Arg Gly Cys Ser Leu Trp Cys Val Glu Leu Ile Arg Asp
                 280                 285                 290

 tgt ctt ctg gag ctt att gaa caa aag ggt gaa aaa cct aat gga gag     1148
 Cys Leu Leu Glu Leu Ile Glu Gln Lys Gly Glu Lys Pro Asn Gly Glu
             295                 300                 305

 atc aat tcc att ctt ctg gat tat tac tta tgg gac tat gcc cat gac     1196
 Ile Asn Ser Ile Leu Leu Asp Tyr Tyr Leu Trp Asp Tyr Ala His Asp
         310                 315                 320

 cat agg gaa gat atg aaa gga att ccg ttt cat cgc ata cgt tgc ata     1244
 His Arg Glu Asp Met Lys Gly Ile Pro Phe His Arg Ile Arg Cys Ile
     325                 330                 335

 tat tat tga cctcaag tgtaaactga tccaaagaaa accccctgcg ttttatatca     1300
 Tyr Tyr 
 340

 tatcatctgt acagttttgc tttgatattt agagaacatg atcgaggtta taggaaattg   1360

 attgcccatt ctcacttgaa aaatacttcc taggccgggc acagtggttt atgcctgtaa   1420

 tcccagcact gtgggaggct gaggcgggtg gatcatctga gatcaggagt ttgagaccac   1480

 ctggccaaca tggtgaaacc ccatctctac taaaaataca aaattagctg ggcgtggtgg   1540

 cacgtgcctg taatcccagt tacttgggag gctgaggcaa gagaatcgct tga          1593




      <210> 72
      <211> 2671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (228)..(2012)

      <400> 72
 gcgcacggct tgcccatgtg tgctgcagcc gtcagccggc ccagctgagc agcagcaacg     60

 gaccttgtta acggcgcggc agcctccacc gcctgctgtt gccctcctct ctcggtggtc    120

 tgtccgccca gcgcacgtca ccatgggcaa gagccggacg aagcgcttca agcgacctca    180

 gttctcccct acgggcgact gtcaggccga ggcggctgcg gcggcga  atg gga ccg     236
                                                      Met Gly Pro
                                                        1

 gag gcg agg agg acg acg ggc cgg cgg cgg agc tgc tgg aaa aga aat      284
 Glu Ala Arg Arg Thr Thr Gly Arg Arg Arg Ser Cys Trp Lys Arg Asn
       5                  10                  15

 ccc agt gct tgt gga ggt ttt gaa gtt tgt gat gac atg gtg act aag      332
 Pro Ser Ala Cys Gly Gly Phe Glu Val Cys Asp Asp Met Val Thr Lys
  20                  25                  30                  35

 gat atc atg acc cct ctg gtt gcg ctg cta aaa gag tgt agt gct gga      380
 Asp Ile Met Thr Pro Leu Val Ala Leu Leu Lys Glu Cys Ser Ala Gly
                  40                  45                  50

 ctg gat tca aat gag atg tct ctg cag gag aaa aaa gat cag aac aga      428
 Leu Asp Ser Asn Glu Met Ser Leu Gln Glu Lys Lys Asp Gln Asn Arg
              55                  60                  65

 aat tct att gag aac ata gcc aat gag act gtg aac gtg ctg tgg aat      476
 Asn Ser Ile Glu Asn Ile Ala Asn Glu Thr Val Asn Val Leu Trp Asn
          70                  75                  80

 ata tgt gaa tgc agt agt aga gca gtg tct ata ttc aac aaa gaa ggg      524
 Ile Cys Glu Cys Ser Ser Arg Ala Val Ser Ile Phe Asn Lys Glu Gly
      85                  90                  95

 tgt ttg gag att gtg tta aag tat tta agt agg ttc cct acc aat gtt      572
 Cys Leu Glu Ile Val Leu Lys Tyr Leu Ser Arg Phe Pro Thr Asn Val
 100                 105                 110                 115

 gac ctg gct att tca gta gca tat tgt ttg cag aca gtg act gag gat      620
 Asp Leu Ala Ile Ser Val Ala Tyr Cys Leu Gln Thr Val Thr Glu Asp
                 120                 125                 130

 aac cca gag ctg ctg aag tct ttc agt gct aca gca ttg aac atg ctg      668
 Asn Pro Glu Leu Leu Lys Ser Phe Ser Ala Thr Ala Leu Asn Met Leu
             135                 140                 145

 gaa tca gca ctg ctt tct cct gtc agt tcc atg gaa tct ctt cta ttg      716
 Glu Ser Ala Leu Leu Ser Pro Val Ser Ser Met Glu Ser Leu Leu Leu
         150                 155                 160

 aag aca ttg gta gca ggc aca att tgg aat cta aag gac att att cca      764
 Lys Thr Leu Val Ala Gly Thr Ile Trp Asn Leu Lys Asp Ile Ile Pro
     165                 170                 175

 tgc aag agt caa gca gaa atc ata aat gcc tta cta aag atc tta tct      812
 Cys Lys Ser Gln Ala Glu Ile Ile Asn Ala Leu Leu Lys Ile Leu Ser
 180                 185                 190                 195

 gaa gtt ttg gga atg gat gct ggt gaa atg gtt att caa atg aaa gag      860
 Glu Val Leu Gly Met Asp Ala Gly Glu Met Val Ile Gln Met Lys Glu
                 200                 205                 210

 gct gaa acg caa agg tta aaa act gct gca gag gct gag gaa ata tta      908
 Ala Glu Thr Gln Arg Leu Lys Thr Ala Ala Glu Ala Glu Glu Ile Leu
             215                 220                 225

 gag aac act aat ggg gat gat ttg att gaa gat gat gaa atg gaa gga      956
 Glu Asn Thr Asn Gly Asp Asp Leu Ile Glu Asp Asp Glu Met Glu Gly
         230                 235                 240

 att tct cat aaa aga aga gtc aga agg aaa act ttc gtt tca gat tta     1004
 Ile Ser His Lys Arg Arg Val Arg Arg Lys Thr Phe Val Ser Asp Leu
     245                 250                 255

 ctt ccg ccc act gac aag gaa ctg aga gag act ata gca ttg ctg aca     1052
 Leu Pro Pro Thr Asp Lys Glu Leu Arg Glu Thr Ile Ala Leu Leu Thr
 260                 265                 270                 275

 gcc caa cag act gct ctg gaa att att gtc aac atg tgc tgc aat gaa     1100
 Ala Gln Gln Thr Ala Leu Glu Ile Ile Val Asn Met Cys Cys Asn Glu
                 280                 285                 290

 gat ccc tct gat gac gaa tgg gaa gag ctt tct agc agt gat gaa agt     1148
 Asp Pro Ser Asp Asp Glu Trp Glu Glu Leu Ser Ser Ser Asp Glu Ser
             295                 300                 305

 gac gca ttt atg gag aat tcc ttc agt gag tgc ggg gga cag ctg ttt     1196
 Asp Ala Phe Met Glu Asn Ser Phe Ser Glu Cys Gly Gly Gln Leu Phe
         310                 315                 320

 tct ccc ctc tgc ctc tcc cat gaa gtt cac acg gct ctc acc aac tac     1244
 Ser Pro Leu Cys Leu Ser His Glu Val His Thr Ala Leu Thr Asn Tyr
     325                 330                 335

 ctc atc cca aag aag att ttt gag aaa act gcc ttt cca aac agc att     1292
 Leu Ile Pro Lys Lys Ile Phe Glu Lys Thr Ala Phe Pro Asn Ser Ile
 340                 345                 350                 355

 gca gtt gac cta tgt tct agg aac cct act tgg aaa cct ttg att aga     1340
 Ala Val Asp Leu Cys Ser Arg Asn Pro Thr Trp Lys Pro Leu Ile Arg
                 360                 365                 370

 aaa atg aac act att cag tgc aga gcc ctc ttc tgt ctc cag agt ctt     1388
 Lys Met Asn Thr Ile Gln Cys Arg Ala Leu Phe Cys Leu Gln Ser Leu
             375                 380                 385

 gtg tcc ctc ctg gat gtg gag cac ctg gga gga gcc gca gcc ctt cag     1436
 Val Ser Leu Leu Asp Val Glu His Leu Gly Gly Ala Ala Ala Leu Gln
         390                 395                 400

 acg ctt gca cag cat ctg tca cag ctg ctt ttt tct caa cca gat ttt     1484
 Thr Leu Ala Gln His Leu Ser Gln Leu Leu Phe Ser Gln Pro Asp Phe
     405                 410                 415

 gct aaa cat gtt gac ttt cta gaa gcc ata agt agt gct ttg agg gcc     1532
 Ala Lys His Val Asp Phe Leu Glu Ala Ile Ser Ser Ala Leu Arg Ala
 420                 425                 430                 435

 ctt ttg caa aca atg gcc tcc aag aac att tcc cag tgc atg act cct     1580
 Leu Leu Gln Thr Met Ala Ser Lys Asn Ile Ser Gln Cys Met Thr Pro
                 440                 445                 450

 gat cag ctg atg aca tta tgc aaa gca ggc att cat agt agt aat gtc     1628
 Asp Gln Leu Met Thr Leu Cys Lys Ala Gly Ile His Ser Ser Asn Val
             455                 460                 465

 ggg gtt aga gtg aat gtc gtt agc att tta gga atc act ggc agc gtc     1676
 Gly Val Arg Val Asn Val Val Ser Ile Leu Gly Ile Thr Gly Ser Val
         470                 475                 480

 ctt gcc aaa gaa gat ggt aca ctt gaa act ctt aag aac att ggg tgc     1724
 Leu Ala Lys Glu Asp Gly Thr Leu Glu Thr Leu Lys Asn Ile Gly Cys
     485                 490                 495

 ttt ctg ctt gaa gtt acc acc aaa gat cct tcc ctt gtg gta gca gga     1772
 Phe Leu Leu Glu Val Thr Thr Lys Asp Pro Ser Leu Val Val Ala Gly
 500                 505                 510                 515

 gaa gct ttg gat gcc ctc ttt gat gtt ttt gca gat ggt aaa gaa gcc     1820
 Glu Ala Leu Asp Ala Leu Phe Asp Val Phe Ala Asp Gly Lys Glu Ala
                 520                 525                 530

 gaa aga gcc tcg att caa att aaa tta tta tct gct ctg aaa gaa ttc     1868
 Glu Arg Ala Ser Ile Gln Ile Lys Leu Leu Ser Ala Leu Lys Glu Phe
             535                 540                 545

 cag ccg gtc ttt aaa atg aag ata cgt aaa gaa ggg aga ggt aac tat     1916
 Gln Pro Val Phe Lys Met Lys Ile Arg Lys Glu Gly Arg Gly Asn Tyr
         550                 555                 560

 agc aca gat cag ctg tgt gtt ctt gac aat gtg aaa atg aat ttg cga     1964
 Ser Thr Asp Gln Leu Cys Val Leu Asp Asn Val Lys Met Asn Leu Arg
     565                 570                 575

 aga ttt att gct tat caa gaa act gtt gag aaa aga ctg act tct taa     2012
 Arg Phe Ile Ala Tyr Gln Glu Thr Val Glu Lys Arg Leu Thr Ser 
 580                 585                 590

 acaatccaaa aaagaaacca gttcttcccc caaagtattc aatgcttaga atactaaaag   2072

 gttttctttg aatgtatatg tttctgaaag tcatttttta atgattacag gcatgagcca   2132

 ccgtgcctgg ccagaaactc ttttttaagc gatgagatct gtgtggcatt tctagcgctc   2192

 tctaaattat gtctctggca tattttaatc actggaaact caaagagtgg aagagtggaa   2252

 gtgcgaagga atctcaggta gctcttaact aattcgccag cagtgaagaa acttcaacca   2312

 atcatgtttt ccttgaattt tgcaaagaaa gaaaatccaa agcattgctt ggatgttctt   2372

 ttaaggcatt ttatatcagt tgaaccttaa actgaaatat gaagacaagc tttataaact   2432

 agttttttga tatgaagtat atcaattatg tttgcctttt gtgaagaagt aaatgagttg   2492

 aatttgtatt tcacttacta gattatacta atgagctaat ggggtcattg ccatcctccc   2552

 tactcatgac tttgatgagt tattgctgta acatcacttc ttgatttaat ttgatatgga   2612

 atcagaattg ggagaaggta tttttaaata aacaactttt taatggaaaa aaaaaaaaa    2671




      <210> 73
      <211> 824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (25)..(726)

      <400> 73
 tggggcgcgg gcgatttgta ggta   atg gca ggc gtt cgg tca ctg agg tgt      51
                              Met Ala Gly Val Arg Ser Leu Arg Cys
                                1               5

 agc aga gga tgc gct ggc ggc tgt gag tgc ggc gac aag ggc aaa tgc       99
 Ser Arg Gly Cys Ala Gly Gly Cys Glu Cys Gly Asp Lys Gly Lys Cys
  10                  15                  20                  25

 agc gac tcc tcg ctg ttg ggc aag aga ctc tcc gaa gac tcg agc cgc      147
 Ser Asp Ser Ser Leu Leu Gly Lys Arg Leu Ser Glu Asp Ser Ser Arg
                  30                  35                  40

 cac cag ctg ttg cag aag tgg gcg agc atg tgg agc tcc atg agc gaa      195
 His Gln Leu Leu Gln Lys Trp Ala Ser Met Trp Ser Ser Met Ser Glu
              45                  50                  55

 gac gcg tcg gtg gcc gac atg gag agg gcg cag ctg gag gag gag gcg      243
 Asp Ala Ser Val Ala Asp Met Glu Arg Ala Gln Leu Glu Glu Glu Ala
          60                  65                  70

 gcg gct gcg gag gag agg ccg ctg gtg ttc ctg tgc tcc ggc tgc cgg      291
 Ala Ala Ala Glu Glu Arg Pro Leu Val Phe Leu Cys Ser Gly Cys Arg
      75                  80                  85

 cgg ccg ctg ggc gac tcg ctg agc tgg gtg gcc agc cag gag gac acc      339
 Arg Pro Leu Gly Asp Ser Leu Ser Trp Val Ala Ser Gln Glu Asp Thr
  90                  95                 100                 105

 aac tgc atc ctg ctt cgc tgt gtt tcc tgt aat gtt tct gtg gat aag      387
 Asn Cys Ile Leu Leu Arg Cys Val Ser Cys Asn Val Ser Val Asp Lys
                 110                 115                 120

 gaa cag aag cta tcc aaa cgt gaa aag gaa aat ggt tgc gtc ctt gag      435
 Glu Gln Lys Leu Ser Lys Arg Glu Lys Glu Asn Gly Cys Val Leu Glu
             125                 130                 135

 act ttg tgc tgc gcg ggg tgc tca ctc aat ctt ggc tac gtg tac aga      483
 Thr Leu Cys Cys Ala Gly Cys Ser Leu Asn Leu Gly Tyr Val Tyr Arg
         140                 145                 150

 tgc acg ccc aag aat ctt gat tac aag aga gac ttg ttt tgc ctc agt      531
 Cys Thr Pro Lys Asn Leu Asp Tyr Lys Arg Asp Leu Phe Cys Leu Ser
     155                 160                 165

 gtt gaa gcc att gaa agt tat gtt tta ggg tcc tct gaa aag caa att      579
 Val Glu Ala Ile Glu Ser Tyr Val Leu Gly Ser Ser Glu Lys Gln Ile
 170                 175                 180                 185

 gtg tca gaa gat aaa gag ctt ttt aat ctt gaa agc aga gtt gaa ata      627
 Val Ser Glu Asp Lys Glu Leu Phe Asn Leu Glu Ser Arg Val Glu Ile
                 190                 195                 200

 gaa aag tct cta aca cag atg gaa gat gtc ttg aaa gca tta caa atg      675
 Glu Lys Ser Leu Thr Gln Met Glu Asp Val Leu Lys Ala Leu Gln Met
             205                 210                 215

 aag ctg tgg gag gcc gaa tcc aaa ttg tcc ttt gcc act tgt aaa agc      723
 Lys Leu Trp Glu Ala Glu Ser Lys Leu Ser Phe Ala Thr Cys Lys Ser
         220                 225                 230

 tga actc tagtctgtgt cctccattct gcccccgccc ttcctcccct tatttgttaa      780
 


 atgaagcaac atagtgagac gtcgtctcta caaaaaaaaa aaaa                     824




      <210> 74
      <211> 2200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(1713)

      <400> 74
 atcttttaat tttacaagtt agaagttgga agcctatatt tttatatgaa gtctgatttt     60

 taaatgttgg catctagttt ttgcaaaggt taaatattgt gcaggccaaa taaaaacatc    120

 tgtaggctgg atttggcact taaattccca gtttgtgacc actactctag gcttatttca    180

 gctgatgttc taatc atg tca gat aaa gat gat att gag act cca ctg cta     231
                  Met Ser Asp Lys Asp Asp Ile Glu Thr Pro Leu Leu
                    1               5                  10

 act gaa gca gcc ccc atc ctt gaa gat gga aac tgt gag cca gcc aag      279
 Thr Glu Ala Ala Pro Ile Leu Glu Asp Gly Asn Cys Glu Pro Ala Lys
          15                  20                  25

 aat tct gag tct gtt gac caa ggt gcc aaa cca gag agt aaa tca gaa      327
 Asn Ser Glu Ser Val Asp Gln Gly Ala Lys Pro Glu Ser Lys Ser Glu
      30                  35                  40

 cct gta gtt tcc act cgg aaa aga cca gag acc aaa cct tcc agt gac      375
 Pro Val Val Ser Thr Arg Lys Arg Pro Glu Thr Lys Pro Ser Ser Asp
  45                  50                  55                  60

 ctt gag act tca aaa gtt ctc cct att cag gat aat gtt tcc aaa gat      423
 Leu Glu Thr Ser Lys Val Leu Pro Ile Gln Asp Asn Val Ser Lys Asp
                  65                  70                  75

 gta ccc cag acc aga tgg ggt tat tgg ggg agc tgg ggc aag tcc ata      471
 Val Pro Gln Thr Arg Trp Gly Tyr Trp Gly Ser Trp Gly Lys Ser Ile
              80                  85                  90

 ctc tcc tca gcc tcg gct aca gta gct aca gta gga caa ggc att tca      519
 Leu Ser Ser Ala Ser Ala Thr Val Ala Thr Val Gly Gln Gly Ile Ser
          95                 100                 105

 aat gtc atc gag aag gca gag act tcc ctt gga atc cct agt ccc agt      567
 Asn Val Ile Glu Lys Ala Glu Thr Ser Leu Gly Ile Pro Ser Pro Ser
     110                 115                 120

 gaa att tca act gaa gtc aag tat gta gca gga gag aca aat gcc aaa      615
 Glu Ile Ser Thr Glu Val Lys Tyr Val Ala Gly Glu Thr Asn Ala Lys
 125                 130                 135                 140

 gag aat gaa aac tcc tcc cca gtg gct ggg gca ttt ggt gta ttc tct      663
 Glu Asn Glu Asn Ser Ser Pro Val Ala Gly Ala Phe Gly Val Phe Ser
                 145                 150                 155

 acc atc tct act gct gtt cag agc aca gga aag agt gtt ata agt ggg      711
 Thr Ile Ser Thr Ala Val Gln Ser Thr Gly Lys Ser Val Ile Ser Gly
             160                 165                 170

 ggt ttg gat gcc tta gaa ttc att gga aaa aag aca atg gat gtg ata      759
 Gly Leu Asp Ala Leu Glu Phe Ile Gly Lys Lys Thr Met Asp Val Ile
         175                 180                 185

 gca gaa ggg gat cct gga ttt aaa aga acc aag ggt ctg atg aac cga      807
 Ala Glu Gly Asp Pro Gly Phe Lys Arg Thr Lys Gly Leu Met Asn Arg
     190                 195                 200

 aat gct aca cta tct cag gtt tta cga gag gcg aag gag aaa gaa gag      855
 Asn Ala Thr Leu Ser Gln Val Leu Arg Glu Ala Lys Glu Lys Glu Glu
 205                 210                 215                 220

 ata cgg acc tcc aat gag gtt acc gtg gaa aca gac aag aaa act cat      903
 Ile Arg Thr Ser Asn Glu Val Thr Val Glu Thr Asp Lys Lys Thr His
                 225                 230                 235

 tat ggg cta ctc ttt gat gaa ttt caa ggc ctt tca cat cta gaa gct      951
 Tyr Gly Leu Leu Phe Asp Glu Phe Gln Gly Leu Ser His Leu Glu Ala
             240                 245                 250

 ctg gag atg ctt tcc caa gaa agt gaa ata aag gtg aaa tct atc ctt      999
 Leu Glu Met Leu Ser Gln Glu Ser Glu Ile Lys Val Lys Ser Ile Leu
         255                 260                 265

 aat tct ctg agt gga gaa gaa tta gag act cta aaa gtt gaa tta gag     1047
 Asn Ser Leu Ser Gly Glu Glu Leu Glu Thr Leu Lys Val Glu Leu Glu
     270                 275                 280

 caa ctc aaa gaa aca ttt tct cta gca gaa ttt tgt gaa gaa gag gaa     1095
 Gln Leu Lys Glu Thr Phe Ser Leu Ala Glu Phe Cys Glu Glu Glu Glu
 285                 290                 295                 300

 gaa gag aaa aaa ggg gat gaa gat ttt acc aag gac ata aca gag ctg     1143
 Glu Glu Lys Lys Gly Asp Glu Asp Phe Thr Lys Asp Ile Thr Glu Leu
                 305                 310                 315

 ttt tcc cag ctg cac gtt tcc tcc aaa cca gag aaa ctt gcc agg gca     1191
 Phe Ser Gln Leu His Val Ser Ser Lys Pro Glu Lys Leu Ala Arg Ala
             320                 325                 330

 aga aat acc gcc cac gaa tgg atc agg aag tct ctg acc aag cca tta     1239
 Arg Asn Thr Ala His Glu Trp Ile Arg Lys Ser Leu Thr Lys Pro Leu
         335                 340                 345

 gca gag aat gaa gaa gga gaa aaa cag tcg gaa gca gaa aat act gag     1287
 Ala Glu Asn Glu Glu Gly Glu Lys Gln Ser Glu Ala Glu Asn Thr Glu
     350                 355                 360

 caa gtc aac aaa aat tca ata gag gat atc cat gcg ttt gca atc cgg     1335
 Gln Val Asn Lys Asn Ser Ile Glu Asp Ile His Ala Phe Ala Ile Arg
 365                 370                 375                 380

 agc ctg gct gaa ctg act gcc tgc tca att gaa cta ttc cac aaa aca     1383
 Ser Leu Ala Glu Leu Thr Ala Cys Ser Ile Glu Leu Phe His Lys Thr
                 385                 390                 395

 gct gca ttg gtt ctg cat ggc agg aag cag gaa gtg aca gcc ata gaa     1431
 Ala Ala Leu Val Leu His Gly Arg Lys Gln Glu Val Thr Ala Ile Glu
             400                 405                 410

 agg agc caa act ctt tcc cag atg aca att gtg ttg tgt aaa gag ttg     1479
 Arg Ser Gln Thr Leu Ser Gln Met Thr Ile Val Leu Cys Lys Glu Leu
         415                 420                 425

 tcc tct ctg tct aaa gag ttc act acc tgc cta aca act gct ggg gtc     1527
 Ser Ser Leu Ser Lys Glu Phe Thr Thr Cys Leu Thr Thr Ala Gly Val
     430                 435                 440

 aaa gaa atg gca gat gtc ctt aac cca tta atc act gca gta ttt cta     1575
 Lys Glu Met Ala Asp Val Leu Asn Pro Leu Ile Thr Ala Val Phe Leu
 445                 450                 455                 460

 gag gca tca aac agt gcc tcc tac atc cag gac gcc ttt cag cta ctc     1623
 Glu Ala Ser Asn Ser Ala Ser Tyr Ile Gln Asp Ala Phe Gln Leu Leu
                 465                 470                 475

 tta cct gtg cta gag atc tct ctc att gag aac aag att gaa tca cac     1671
 Leu Pro Val Leu Glu Ile Ser Leu Ile Glu Asn Lys Ile Glu Ser His
             480                 485                 490

 aga cat gag ctg cag ggc cag aaa cct ttg tta gaa cat tga agaatgg     1720
 Arg His Glu Leu Gln Gly Gln Lys Pro Leu Leu Glu His 
         495                 500                 505

 agacgttttg acctgggact tgtgacggcc aaggaatgcc accttattct ggctactcct   1780

 gcagaaatga aggagtgggg ttattttagt atataaaaat tcaggcagga gagatggttt   1840

 aaagaggaag attgttgcct tcagtgtttg attgaagtat tcaggttctc acagtattct   1900

 ttccagttgt tgtaattcat aaattatttg aaaagaaact tttgtagaaa gtccaagaat   1960

 aataactcta gataaagatt agtgggacac tcaggcaaaa atgttggtct ttctttgaca   2020

 tgttgcaaaa tgttatcaat tttgtcatgg atataatttg cagcccatgg atataactgg   2080

 ttgataagcc agagaaaaat aatttagtgt tctaaaattc atggcatgtg tggtttatta   2140

 atgccatgta ctttctcctt tctggaataa aatctatggc tttaagaaaa aaaaaaaaaa   2200




      <210> 75
      <211> 2818
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(1112)

      <400> 75
 cacgaaaccc cctaaagcct taaaataaac tttctttgat ttcttctctt ttggtttgtg     60

 tttctgtttt tccagaaaat gttcctgaga aagatcttca tggaagactt tttatcaacc    120

 gtatttttca tatcagtgct gacaga atg ttt gaa ttg ctc ttt acc agt tca     173
                              Met Phe Glu Leu Leu Phe Thr Ser Ser
                                1               5

 cgc ttt atg cag aaa ttt gcc agt tct aga aat ata ata gat gta gta      221
 Arg Phe Met Gln Lys Phe Ala Ser Ser Arg Asn Ile Ile Asp Val Val
  10                  15                  20                  25

 tct acc cct tgg act gca gaa ctt gga ggt gat cag ctg aga acg atg      269
 Ser Thr Pro Trp Thr Ala Glu Leu Gly Gly Asp Gln Leu Arg Thr Met
                  30                  35                  40

 acc tac act ata gtc ctt aat agt cca ctt act gga aaa tgc act gct      317
 Thr Tyr Thr Ile Val Leu Asn Ser Pro Leu Thr Gly Lys Cys Thr Ala
              45                  50                  55

 gcc act gaa aag cag aca ctg tat aaa gaa agt cgg gaa gca cga ttt      365
 Ala Thr Glu Lys Gln Thr Leu Tyr Lys Glu Ser Arg Glu Ala Arg Phe
          60                  65                  70

 tat ttg gta gat tca gaa gta ctg aca cat gat gtc ccc tac cat gat      413
 Tyr Leu Val Asp Ser Glu Val Leu Thr His Asp Val Pro Tyr His Asp
      75                  80                  85

 tac ttc tat acc gtg aac aga tac tgt atc atc cga tct tca aaa cag      461
 Tyr Phe Tyr Thr Val Asn Arg Tyr Cys Ile Ile Arg Ser Ser Lys Gln
  90                  95                 100                 105

 aaa tgc agg cta aga gtt tcc aca gat ttg aaa tac aga aaa cag cca      509
 Lys Cys Arg Leu Arg Val Ser Thr Asp Leu Lys Tyr Arg Lys Gln Pro
                 110                 115                 120

 tgg ggc ctt gtc aaa tct tta att gaa aag aat tcc tgg agt tct ttg      557
 Trp Gly Leu Val Lys Ser Leu Ile Glu Lys Asn Ser Trp Ser Ser Leu
             125                 130                 135

 gag gac tat ttc aaa cag ctt gaa tca gat ttg tta att gaa gaa tct      605
 Glu Asp Tyr Phe Lys Gln Leu Glu Ser Asp Leu Leu Ile Glu Glu Ser
         140                 145                 150

 gta tta aat cag gcc att gaa gac cct gga aaa ctt act ggc cta cga      653
 Val Leu Asn Gln Ala Ile Glu Asp Pro Gly Lys Leu Thr Gly Leu Arg
     155                 160                 165

 agg aga agg cga acc ttc aac cga aca gca gaa aca gtt cct aaa ctt      701
 Arg Arg Arg Arg Thr Phe Asn Arg Thr Ala Glu Thr Val Pro Lys Leu
 170                 175                 180                 185

 tcc tct cag cat tcc tct gga gat gtg ggc tta ggt gcc aaa ggg gat      749
 Ser Ser Gln His Ser Ser Gly Asp Val Gly Leu Gly Ala Lys Gly Asp
                 190                 195                 200

 att aca gga aag aaa aag gaa atg gaa aac tat aac gtc act ctt att      797
 Ile Thr Gly Lys Lys Lys Glu Met Glu Asn Tyr Asn Val Thr Leu Ile
             205                 210                 215

 gtg gta atg agt att ttt gtg ttg tta tta gtt ttg ttg aat gtg aca      845
 Val Val Met Ser Ile Phe Val Leu Leu Leu Val Leu Leu Asn Val Thr
         220                 225                 230

 ctg ttt ctg aag ctg tca aag ata gaa cat gct gct cag tcc ttt tac      893
 Leu Phe Leu Lys Leu Ser Lys Ile Glu His Ala Ala Gln Ser Phe Tyr
     235                 240                 245

 cgt ctc cgc ctc caa gaa gag aaa tct tta aat tta gcc tct gat atg      941
 Arg Leu Arg Leu Gln Glu Glu Lys Ser Leu Asn Leu Ala Ser Asp Met
 250                 255                 260                 265

 gtg tca aga gca gaa act att cag aag aat aaa gat cag gcc cat cgt      989
 Val Ser Arg Ala Glu Thr Ile Gln Lys Asn Lys Asp Gln Ala His Arg
                 270                 275                 280

 tta aag gga gtg ctc cga gac tcc ata gtg atg ctt gaa cag ctg aag     1037
 Leu Lys Gly Val Leu Arg Asp Ser Ile Val Met Leu Glu Gln Leu Lys
             285                 290                 295

 agc tca ctc att atg ctt cag aaa acg ttt gat cta cta aat aag aat     1085
 Ser Ser Leu Ile Met Leu Gln Lys Thr Phe Asp Leu Leu Asn Lys Asn
         300                 305                 310

 aag act ggc atg gct gtt gaa agc tag tgatc tgaaggacta aaaccgcaga     1137
 Lys Thr Gly Met Ala Val Glu Ser 
     315                 320

 gatacttgga acttaaagaa aatacctgga agaaaaccag acgaatgaag gattttggca   1197

 tagaacattt ctatgttttt tcattattga gatttctaat atgaacattt ctttcagtaa   1257

 catttatttg ataattagtt tctgctggcc ttaataatcc atcctttcac ttcttataga   1317

 tatttttaag ctgtgaattt cttcagtgaa ccatgaaata tattatagaa ctgaatttct   1377

 ctgatacaaa aagaaaatga cacaccctga attgagtggt atggtctcat ttctacagtg   1437

 aagtctgatg ctttgttagc acagaatccg tacatgtcca ataggtcgct tttgtaactg   1497

 agataagacc aagaggataa acaggacaat ataagaagaa acctctatgt cattactgat   1557

 tttaaaggtt ctgttttcag gcatataaca tttccaggtt tgtgtactgt aaagattata   1617

 atgtcttcat ttatttagca tgcaaattta atagtcaaac tttttgaatc tgcatgttga   1677

 tgatgattat cagaaagggt cttctgccat gctgtatctt tatgaaagaa atagttgttt   1737

 tttcttaagg taactatcag aggtgggatt atcttgcctc ctcacttaga ataccaacag   1797

 tcaaaaggaa gaaccatcct ctgagtttta aaaaccagaa ggttatgtta aaatctgggc   1857

 atttagtgac agatcaaatg catacttgaa ctaagattgg cttcagctta gcagtctttc   1917

 atggtggaag tgacacatct ggttgaaaat aatttgtgta ttttcagtaa ccatgtatgg   1977

 cttccttctt tatgtatgtg tgtgacttgt tttgattggt aagttataag ccagacatag   2037

 attttagctc tttaataaaa acttcagggg cacgtatgtc ccagtacaag tgtactgact   2097

 atcaagtttt aactcagatg caagctttgg ctctttcata aaaagttttt atgcatatgt   2157

 gtctccatac aagtggctca ttaaaataag aactttgtaa actgacttaa aatcagatat   2217

 tttttcaaga gttagggaaa gttgaagtgt tttactgttt tgtctcttga gccctttctc   2277

 tggggaaaaa atacatatcc atctatctat ctatatataa actgtgtata cattcttact   2337

 gtttgaacaa ctattgcctt taattaaatg tttcattttt ctccagagtc cccaaagcca   2397

 catggcatta ttatagtcat ttttgagatg cctgtagaga atgaaagtat tgactccgtt   2457

 agagggaaaa tgggtttctc tgggtgaatt ccaacgaagc atacctaggg gtaacagtga   2517

 acctacctgg gtttgttttg ttttggtaag gatttatgta gtgtctggct gtaagcaaga   2577

 atgagtggat tataaacttg aagatttctc tgttaaagtc acaaaaatga tcgacaaaca   2637

 atatttttgt gatgtttatt taaacgttgt attttataac atacttcaag gaagagtatc   2697

 gaagtaagtt gctttataaa ttaagactaa attcgtatgg atgcagaatt caattaataa   2757

 aatttgagcc tgttacgtaa attgaatatt aataaaattg aaaatttcaa aaaaaaaaaa   2817

 a                                                                   2818




      <210> 76
      <211> 1946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (465)..(1307)

      <400> 76
 tacatggcga gcaaaaaaac aacgctgaga gaatcttttc tctaatgcca gagaaaaatg     60

 aacattccta ttgcacaatg atccgaggaa tggtgaagct gatgtataca catttaatgc    120

 attgattgaa gcaacagtat gtgcgataaa tgagaaattt gaggaaaaat ggagtaaaat    180

 actggagctg ctaagacaca tggttgcaca gaaggtgaaa ccaaatcttc agacttttaa    240

 taccattctg aaatgtctcc gaagatttca tgtgtttgca agatcgccag ccttacaggt    300

 tttacgtgaa atgaaagcca ttggaataga accctcgctt gcaacatatc accatattat    360

 tcgcctgttt gatcaacctg gagacccttt aaagagatca tccttcatca tttatgatat    420

 aatgaatgaa ttaatgggaa agagattttc tccaaaggac ccgg atg atg gca tat     476
                                                  Met Met Ala Tyr
                                                    1

 aag ttt ttt cag tca gcc atg agc ata tgc tca tct ctc aga gat cta      524
 Lys Phe Phe Gln Ser Ala Met Ser Ile Cys Ser Ser Leu Arg Asp Leu
   5                  10                  15                  20

 gaa ctt gcc tac caa gta cat ggc ctt tta aaa acc gga gac aac tgg      572
 Glu Leu Ala Tyr Gln Val His Gly Leu Leu Lys Thr Gly Asp Asn Trp
                  25                  30                  35

 aaa ttc att gga cct gat caa cat cgt aat ttc tat tat tcc aag ttc      620
 Lys Phe Ile Gly Pro Asp Gln His Arg Asn Phe Tyr Tyr Ser Lys Phe
              40                  45                  50

 ttc gat ttg att tgt cta atg gaa caa att gat gtt acc ttg aag tgg      668
 Phe Asp Leu Ile Cys Leu Met Glu Gln Ile Asp Val Thr Leu Lys Trp
          55                  60                  65

 tat gag gac ctg ata cct tca gcc tac ttt ccc cac tcc caa aca atg      716
 Tyr Glu Asp Leu Ile Pro Ser Ala Tyr Phe Pro His Ser Gln Thr Met
      70                  75                  80

 ata cat ctt ctc caa gca ttg gat gtg gcc aat cgg cta gaa gtg att      764
 Ile His Leu Leu Gln Ala Leu Asp Val Ala Asn Arg Leu Glu Val Ile
  85                  90                  95                 100

 cct aaa att tgg aaa gat agt aaa gaa tat ggt cat act ttc cgc agt      812
 Pro Lys Ile Trp Lys Asp Ser Lys Glu Tyr Gly His Thr Phe Arg Ser
                 105                 110                 115

 gac ctg aga gaa gag atc ctg atg ctc atg gca agg gac aag cac cca      860
 Asp Leu Arg Glu Glu Ile Leu Met Leu Met Ala Arg Asp Lys His Pro
             120                 125                 130

 cca gag ctt cag gtg gca ttt gct gac tgt gct gct gat atc aaa tct      908
 Pro Glu Leu Gln Val Ala Phe Ala Asp Cys Ala Ala Asp Ile Lys Ser
         135                 140                 145

 gcg tat gaa agc caa ccc atc aga cag act gct cag gat tgg cca gcc      956
 Ala Tyr Glu Ser Gln Pro Ile Arg Gln Thr Ala Gln Asp Trp Pro Ala
     150                 155                 160

 acc tct ctc aac tgt ata gct atc ctc ttt tta agg gct ggg aga act     1004
 Thr Ser Leu Asn Cys Ile Ala Ile Leu Phe Leu Arg Ala Gly Arg Thr
 165                 170                 175                 180

 cag gaa gcc tgg aaa atg ttg ggg ctt ttc agg aag cat aat aag att     1052
 Gln Glu Ala Trp Lys Met Leu Gly Leu Phe Arg Lys His Asn Lys Ile
                 185                 190                 195

 cct aga agt gag ttg ctg aat gag ctt atg gac agt gca aaa gtg tct     1100
 Pro Arg Ser Glu Leu Leu Asn Glu Leu Met Asp Ser Ala Lys Val Ser
             200                 205                 210

 aac agc cct tcc cag gcc att gaa gta gta gag ctg gca agt gcc ttc     1148
 Asn Ser Pro Ser Gln Ala Ile Glu Val Val Glu Leu Ala Ser Ala Phe
         215                 220                 225

 agc tta cct att tgt gag ggc ctc acc cag aga gta atg agt gat ttt     1196
 Ser Leu Pro Ile Cys Glu Gly Leu Thr Gln Arg Val Met Ser Asp Phe
     230                 235                 240

 gca atc aac cag gaa caa aag gaa gcc cta agt aat cta act gca ttg     1244
 Ala Ile Asn Gln Glu Gln Lys Glu Ala Leu Ser Asn Leu Thr Ala Leu
 245                 250                 255                 260

 acc agt gac agt gat act gac agc agc agt gac agc gac agt gac acc     1292
 Thr Ser Asp Ser Asp Thr Asp Ser Ser Ser Asp Ser Asp Ser Asp Thr
                 265                 270                 275

 agt gaa ggc aaa tga aagtggagat tcaggagcag caatggtctc accatagctg     1347
 Ser Glu Gly Lys 
             280

 ctggaatcac acctgagaac tgagatatac caatatttaa cattgttaca aagaagaaaa   1407

 gatacagatt tggtgaattt gttactgtga ggtacagtca gtacacagct gacttatgta   1467

 gatttaagct gctaatatgc tacttaacca tctattaatg caccattaaa ggcttagcat   1527

 ttaagtagca acattgcggt tttcagacac atggtgaggt ccatggctct tgtcatcagg   1587

 ataagcctgc acacctagag tgtcggtgag ctgacctcac gatgctgtcc tcgtgcgatt   1647

 gccctctcct gctgctggac ttctgccttt gttggcctga tgtgctgctg tgatgctggt   1707

 ccttcatctt aggtgttcat gcagttctaa cacagttggg gttgggtcaa tagtttccca   1767

 atttcaggat atttcgatgt cagaaataac gcatcttagg aatgactaaa caagataatg   1827

 gcagtttagg ctgcacaact ggtaaaatga ctgtagataa atgttgtaat tagtgtacac   1887

 gtttgtattt ttgttaatat agccgctgcc atagttttct aacttgaaaa aaaaaaaaa    1946




      <210> 77
      <211> 781
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (269)..(727)

      <400> 77
 cgtcgcggaa ttcaatacag gctcaaagca ggcgacggga caggaatgag aggatggatg     60

 ctggcagggg cttggagagt ctgagaagcc aactggggcc aaacaagttt tagaacctct    120

 actggctgat gccaacatca tcagagatga actgttctta ccagaaactt ctctgctcct    180

 gacaccccac ctctccccag aagagaagaa ggagagtggc cacgttgatt cagccaagca    240

 cctccaggag gtcccctctg gatgtccc   atg agg ctg ccc ctc agc cac agc     292
                                  Met Arg Leu Pro Leu Ser His Ser
                                    1               5

 cca gag cac gtg gag atg gct ttg ctc agc aac atc cta gcg gcc tat      340
 Pro Glu His Val Glu Met Ala Leu Leu Ser Asn Ile Leu Ala Ala Tyr
      10                  15                  20

 tcc ttt gtc tca gaa aat cct gag cga gca gct ctg tac ttt gtt tct      388
 Ser Phe Val Ser Glu Asn Pro Glu Arg Ala Ala Leu Tyr Phe Val Ser
  25                  30                  35                  40

 ggc gtg tgc atc ggg ctg gtg ctg acc ctg gct gct ttg gtg ata agg      436
 Gly Val Cys Ile Gly Leu Val Leu Thr Leu Ala Ala Leu Val Ile Arg
                  45                  50                  55

 atc tct tgc cac aca gac tgc agg cgg cgt ccc ggg aag aag ttc ctg      484
 Ile Ser Cys His Thr Asp Cys Arg Arg Arg Pro Gly Lys Lys Phe Leu
              60                  65                  70

 cag gac aga gag agc agc agc gac agc agc gac agc gag gat ggc agt      532
 Gln Asp Arg Glu Ser Ser Ser Asp Ser Ser Asp Ser Glu Asp Gly Ser
          75                  80                  85

 gag gac acc gtg tcc gat ctc tcc gtg cgg aga cac cgc cgc ttc gag      580
 Glu Asp Thr Val Ser Asp Leu Ser Val Arg Arg His Arg Arg Phe Glu
      90                  95                 100

 agg act ttg aac aag aat gtg ttc acc tct gcg gag gag ctg gag cgc      628
 Arg Thr Leu Asn Lys Asn Val Phe Thr Ser Ala Glu Glu Leu Glu Arg
 105                 110                 115                 120

 gcc cag cgg ctg gag gag cgc gag cgc atc atc agg gag atc tgg atg      676
 Ala Gln Arg Leu Glu Glu Arg Glu Arg Ile Ile Arg Glu Ile Trp Met
                 125                 130                 135

 aat ggc cag cct gag gtg ccc ggg acc agg agc ctg aat cgc tac tat      724
 Asn Gly Gln Pro Glu Val Pro Gly Thr Arg Ser Leu Asn Arg Tyr Tyr
             140                 145                 150

 tag ggag cagcaggacc ccggaaacca ctggaggccg cctggaaagg agagcgtctg      781
 






      <210> 78
      <211> 1031
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (568)..(984)

      <400> 78
 gctgcggaac tgcgcgattg tggttcccgc cgtatttccc gttccccatc tagtaactcc     60

 catctcagcc cacgtatctc cctgagtgga aatctcgggc cccagaccag tcgattggga    120

 ggtccgccct ccccttcagc gacttggtct gtgtttgggc agttgccgcg acaacagtca    180

 cttccgggaa ggggctctgc gaatctcctt ccgtcggtcc gctcagaatc agctgtcctc    240

 tcagactgtg tgggtggttt ccccggccgc agctccgtac gggcttggat tgctgggcct    300

 cggtgcaccc cagcctcccc cactcgggtt ctgagcttga gctggcggct ctttaactct    360

 gcttcactgt tgctcttggc aacatccact tccgggagcg agtgccgttt cccccgctca    420

 ccgcgggcta gggagcgtgg gattccggac tgtgagcggc tgttagtgcg tcgcagctgc    480

 tggcgatccg gcgaccctcg gccggcagga cccgcgggcc acgcagccgg ggccttctca    540

 acgcctcagt acctcggcgg gaccgcc    atg gtt ctg ctg cac gtg aag cgg     591
                                  Met Val Leu Leu His Val Lys Arg
                                    1               5

 ggc gac gag agc cag ttc ctg ctg cag gcg cct ggg agt acc gag ctg      639
 Gly Asp Glu Ser Gln Phe Leu Leu Gln Ala Pro Gly Ser Thr Glu Leu
      10                  15                  20

 gag gag ctc acg gtg cag gtg gcc cgg gtc tat aat ggg cgg ctc aag      687
 Glu Glu Leu Thr Val Gln Val Ala Arg Val Tyr Asn Gly Arg Leu Lys
  25                  30                  35                  40

 gtg cag cgc ctc tgc tca gaa atg gaa gaa tta gcc gaa cat ggc ata      735
 Val Gln Arg Leu Cys Ser Glu Met Glu Glu Leu Ala Glu His Gly Ile
                  45                  50                  55

 ttt ctc cct cct aat atg caa gga ctg acc gat gat cag att gaa gaa      783
 Phe Leu Pro Pro Asn Met Gln Gly Leu Thr Asp Asp Gln Ile Glu Glu
              60                  65                  70

 ttg aaa ttg aag gat gaa tgg ggt gaa aaa tgc gta ccc agc gga ggt      831
 Leu Lys Leu Lys Asp Glu Trp Gly Glu Lys Cys Val Pro Ser Gly Gly
          75                  80                  85

 gca gtg ttt aaa aag gat gat att gga cga agg aat ggg caa gaa aca      879
 Ala Val Phe Lys Lys Asp Asp Ile Gly Arg Arg Asn Gly Gln Glu Thr
      90                  95                 100

 agt gga agc cgg tgt ctg tgt tac cat gga gat ggt gaa aga tgc ctt      927
 Ser Gly Ser Arg Cys Leu Cys Tyr His Gly Asp Gly Glu Arg Cys Leu
 105                 110                 115                 120

 gga cca gct tcg agg cgc ggt gat gat tgt tta ccc cat ggg gtt gcc      975
 Gly Pro Ala Ser Arg Arg Gly Asp Asp Cys Leu Pro His Gly Val Ala
                 125                 130                 135

 acc gta tga tcccatc cgcatggagt ttgaaaataa ggaagacttg tcgggaacac     1031
 Thr Val 






      <210> 79
      <211> 766
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(479)

      <220>
      <221> misc_feature
      <222> (1)...(766)
      <223> n = a,t,c or g

      <400> 79
 gagcggtaac tgcgtatgag aaccgtacga ggngggccga cgggtcgccg ctgcgccggg     60

 ccggg    atg gcg gcc acc gcg ctg ctg gag gcc ggc ctg gcg cgg gtg     107
          Met Ala Ala Thr Ala Leu Leu Glu Ala Gly Leu Ala Arg Val
            1               5                  10

 ctc ttc tac ccg acg ctg ctc tac acc ctg ttc cgc ggg aag gtg ccg      155
 Leu Phe Tyr Pro Thr Leu Leu Tyr Thr Leu Phe Arg Gly Lys Val Pro
  15                  20                  25                  30

 ggt cgg gcg cac cgg gac tgg tac cac cgc atc gac ccc acc gtg ctg      203
 Gly Arg Ala His Arg Asp Trp Tyr His Arg Ile Asp Pro Thr Val Leu
                  35                  40                  45

 ctg ggc gcg ctg ccg ttg cgg agc ttg acg cgc cag ctg gta cag gac      251
 Leu Gly Ala Leu Pro Leu Arg Ser Leu Thr Arg Gln Leu Val Gln Asp
              50                  55                  60

 gag aac gtg cgc ggg gtg atc acc atg aac gag gag tac gag acg agg      299
 Glu Asn Val Arg Gly Val Ile Thr Met Asn Glu Glu Tyr Glu Thr Arg
          65                  70                  75

 ttc ctg tgc aac tct tca cag gtg cac aaa tgg agt cca gag gag gct      347
 Phe Leu Cys Asn Ser Ser Gln Val His Lys Trp Ser Pro Glu Glu Ala
      80                  85                  90

 gta aga gcc atc gcc aag atc cgg tca tac atc cac atc agg cct ggc      395
 Val Arg Ala Ile Ala Lys Ile Arg Ser Tyr Ile His Ile Arg Pro Gly
  95                 100                 105                 110

 cag ctg gat gtt ctt aaa gag ttc cac aag cag att act gca cgg gca      443
 Gln Leu Asp Val Leu Lys Glu Phe His Lys Gln Ile Thr Ala Arg Ala
                 115                 120                 125

 aca aag gat ggg act ttt gtc att tca aag aca tga tgta tggggattag      493
 Thr Lys Asp Gly Thr Phe Val Ile Ser Lys Thr 
             130                 135

 aaagaactca agacactcct gcttgataca gaacaaaaag agcttaacag gaccaacagg    553

 gcttaagccc agacttgacg taacagaaat gtgccaatag gtaataggta atttttcttt    613

 ctctgacttg ttttgttttc ttgaaataac actgttgtgt ggctagaaag gaaaagattt    673

 agtgtggctt gtattcatgg gatacaggac agggatgggg ctatcatctt ttcttgaata    733

 gggctaaaga agtattttac caaaaaaaaa aaa                                 766




      <210> 80
      <211> 2745
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (183)..(2423)

      <400> 80
 cctacattga gctatacctt acatatctgt agaccctcat ttctatcacc acgtgtggag     60

 atttctgcat tttgggtaca gaagctgatg agaatcaccc tcagtttgtg cttttccttt    120

 gcaattctat tggcacaccc ttggacccta aatacattga ttttgtacca ttatttgttg    180

 ca   atg acc caa acc cat gtg ata gca gct tca aaa gaa gca ttt tat     227
      Met Thr Gln Thr His Val Ile Ala Ala Ser Lys Glu Ala Phe Tyr
        1               5                  10                  15

 acc tgg caa tat cgt gtg gca aag aag ctc aca gca ttg gaa att aat      275
 Thr Trp Gln Tyr Arg Val Ala Lys Lys Leu Thr Ala Leu Glu Ile Asn
                  20                  25                  30

 cag atc aca cgg tct cga aaa gaa ggg aga gaa aga att tat cat gtt      323
 Gln Ile Thr Arg Ser Arg Lys Glu Gly Arg Glu Arg Ile Tyr His Val
              35                  40                  45

 gat gat acc cct tct gga tca atg gat ggt gtg ctt gat tat agt aaa      371
 Asp Asp Thr Pro Ser Gly Ser Met Asp Gly Val Leu Asp Tyr Ser Lys
          50                  55                  60

 acc att caa ggc aca agg gat cca att tgt gcc ata act gca tca gat      419
 Thr Ile Gln Gly Thr Arg Asp Pro Ile Cys Ala Ile Thr Ala Ser Asp
      65                  70                  75

 aag ata ttg att gtg ggt cgt gaa tct ggc acc att cag aga tac agt      467
 Lys Ile Leu Ile Val Gly Arg Glu Ser Gly Thr Ile Gln Arg Tyr Ser
  80                  85                  90                  95

 cta cct aat gtt ggt ttg att caa aaa tat tcc ctt aat tgt cga gcc      515
 Leu Pro Asn Val Gly Leu Ile Gln Lys Tyr Ser Leu Asn Cys Arg Ala
                 100                 105                 110

 tac cag tta tcc ttg aat tgc aac tct agc cgt ctt gct atc ata gac      563
 Tyr Gln Leu Ser Leu Asn Cys Asn Ser Ser Arg Leu Ala Ile Ile Asp
             115                 120                 125

 atc tca gga gtt ctg act ttc ttt gac ttg gat gct cga gta acg gac      611
 Ile Ser Gly Val Leu Thr Phe Phe Asp Leu Asp Ala Arg Val Thr Asp
         130                 135                 140

 agt acg gga cag caa gta gtt gga gag ttg tta aaa ttg gaa cga aga      659
 Ser Thr Gly Gln Gln Val Val Gly Glu Leu Leu Lys Leu Glu Arg Arg
     145                 150                 155

 gat gtc tgg gat atg aag tgg gcc aaa gat aat cct gat ttg ttt gca      707
 Asp Val Trp Asp Met Lys Trp Ala Lys Asp Asn Pro Asp Leu Phe Ala
 160                 165                 170                 175

 atg atg gag aag aca aga atg tat gtt ttc aga aac ttg gat cct gag      755
 Met Met Glu Lys Thr Arg Met Tyr Val Phe Arg Asn Leu Asp Pro Glu
                 180                 185                 190

 gaa ccc att cag acc tct gga tat att tgt aat ttt gag gat tta gaa      803
 Glu Pro Ile Gln Thr Ser Gly Tyr Ile Cys Asn Phe Glu Asp Leu Glu
             195                 200                 205

 att aaa tct gtt ctt ttg gat gag ata tta aag gat cca gaa cat cca      851
 Ile Lys Ser Val Leu Leu Asp Glu Ile Leu Lys Asp Pro Glu His Pro
         210                 215                 220

 aac aag gat tac cta att aac ttt gag att cgg tct ctg cga gat agc      899
 Asn Lys Asp Tyr Leu Ile Asn Phe Glu Ile Arg Ser Leu Arg Asp Ser
     225                 230                 235

 cga gca ctg att gag aag gtt gga att aaa gat gca tct cac ttc ata      947
 Arg Ala Leu Ile Glu Lys Val Gly Ile Lys Asp Ala Ser His Phe Ile
 240                 245                 250                 255

 gag gac aat cca cac ccc cga ctt tgg cgc cta ctg gct gaa gca gct      995
 Glu Asp Asn Pro His Pro Arg Leu Trp Arg Leu Leu Ala Glu Ala Ala
                 260                 265                 270

 ctt caa aaa ctg gat cta tac act gca gag caa gca ttt gtg cgc tgc     1043
 Leu Gln Lys Leu Asp Leu Tyr Thr Ala Glu Gln Ala Phe Val Arg Cys
             275                 280                 285

 aaa gat tac caa ggc att aag ttt ggg aag cgc ttg ggc aaa cta ctg     1091
 Lys Asp Tyr Gln Gly Ile Lys Phe Gly Lys Arg Leu Gly Lys Leu Leu
         290                 295                 300

 agt gag tca atg aaa cag gct gaa gtt gtt ggc tac ttc ggc agg ttt     1139
 Ser Glu Ser Met Lys Gln Ala Glu Val Val Gly Tyr Phe Gly Arg Phe
     305                 310                 315

 gaa gag gct gaa aga acg tat ctc gag atg gac aga agg gat ctt gct     1187
 Glu Glu Ala Glu Arg Thr Tyr Leu Glu Met Asp Arg Arg Asp Leu Ala
 320                 325                 330                 335

 att ggc ctc cgg ctg aaa ttg ggg gat tgg ttt aga gta ctc cag ctc     1235
 Ile Gly Leu Arg Leu Lys Leu Gly Asp Trp Phe Arg Val Leu Gln Leu
                 340                 345                 350

 ctg aaa act gga tct ggt gat gca gat gac agt ctc ctg gaa caa gcc     1283
 Leu Lys Thr Gly Ser Gly Asp Ala Asp Asp Ser Leu Leu Glu Gln Ala
             355                 360                 365

 aac aat gcc att gga gac tac ttt gct gat cga caa aag tgg ttg aat     1331
 Asn Asn Ala Ile Gly Asp Tyr Phe Ala Asp Arg Gln Lys Trp Leu Asn
         370                 375                 380

 gct gta caa tat tat gta caa gga cgg aac cag gaa cgc tta gct gaa     1379
 Ala Val Gln Tyr Tyr Val Gln Gly Arg Asn Gln Glu Arg Leu Ala Glu
     385                 390                 395

 tgt tac tat atg tta gag gat tat gag ggg tta gag aac ctt gcc att     1427
 Cys Tyr Tyr Met Leu Glu Asp Tyr Glu Gly Leu Glu Asn Leu Ala Ile
 400                 405                 410                 415

 tca ctt cca gaa aac cac aag tta ctt cca gaa ata gca caa atg ttt     1475
 Ser Leu Pro Glu Asn His Lys Leu Leu Pro Glu Ile Ala Gln Met Phe
                 420                 425                 430

 gtc aga gtt gga atg tgt gaa caa gca gtg act gca ttt ttg aaa tgt     1523
 Val Arg Val Gly Met Cys Glu Gln Ala Val Thr Ala Phe Leu Lys Cys
             435                 440                 445

 agt caa cca aag gca gca gta gat acc tgc gta cat ctc aac caa tgg     1571
 Ser Gln Pro Lys Ala Ala Val Asp Thr Cys Val His Leu Asn Gln Trp
         450                 455                 460

 aac aaa gct gtt gaa ttg gct aaa aat cat agt atg aaa gaa att gga     1619
 Asn Lys Ala Val Glu Leu Ala Lys Asn His Ser Met Lys Glu Ile Gly
     465                 470                 475

 tct ctg tta gct agg tat gca tct cat tta ctg gaa aag aat aaa act     1667
 Ser Leu Leu Ala Arg Tyr Ala Ser His Leu Leu Glu Lys Asn Lys Thr
 480                 485                 490                 495

 ctt gat gcc ata gaa ctc tat cgg aaa gcc aat tac ttt ttt gat gca     1715
 Leu Asp Ala Ile Glu Leu Tyr Arg Lys Ala Asn Tyr Phe Phe Asp Ala
                 500                 505                 510

 gct aaa ctg atg ttt aag att gca gat gaa gag gca aag aaa gga agt     1763
 Ala Lys Leu Met Phe Lys Ile Ala Asp Glu Glu Ala Lys Lys Gly Ser
             515                 520                 525

 aaa cct tta cgt gtc aag aag ctc tat gta ctg tca gcc tta ctt ata     1811
 Lys Pro Leu Arg Val Lys Lys Leu Tyr Val Leu Ser Ala Leu Leu Ile
         530                 535                 540

 gag caa tac cat gaa cag atg aag aat gcc cag cga gga aaa gtt aaa     1859
 Glu Gln Tyr His Glu Gln Met Lys Asn Ala Gln Arg Gly Lys Val Lys
     545                 550                 555

 gga aaa agt tca gag gcc act tct gcc ttg gct ggt ttg ctg gaa gaa     1907
 Gly Lys Ser Ser Glu Ala Thr Ser Ala Leu Ala Gly Leu Leu Glu Glu
 560                 565                 570                 575

 gaa gtt ctg tct aca aca gat cgt ttc aca gat aat gca tgg aga ggg     1955
 Glu Val Leu Ser Thr Thr Asp Arg Phe Thr Asp Asn Ala Trp Arg Gly
                 580                 585                 590

 gca gag gct tac cac ttc ttt ata ctt gca cag agg cag ctc tat gag     2003
 Ala Glu Ala Tyr His Phe Phe Ile Leu Ala Gln Arg Gln Leu Tyr Glu
             595                 600                 605

 gga tgt gtg gac act gca ctg aag aca gct ctt cac ctg aaa gac tat     2051
 Gly Cys Val Asp Thr Ala Leu Lys Thr Ala Leu His Leu Lys Asp Tyr
         610                 615                 620

 gaa gac atc atc cct cct gtg gag atc tac tct ctg cta gca ctc tgc     2099
 Glu Asp Ile Ile Pro Pro Val Glu Ile Tyr Ser Leu Leu Ala Leu Cys
     625                 630                 635

 gca tgc gcc agc aga gcc ttt ggg act tgt tca aaa gct ttc att aaa     2147
 Ala Cys Ala Ser Arg Ala Phe Gly Thr Cys Ser Lys Ala Phe Ile Lys
 640                 645                 650                 655

 ctt aaa tct tta gag acc ctc agt tca gaa cag aaa cag cag tat gaa     2195
 Leu Lys Ser Leu Glu Thr Leu Ser Ser Glu Gln Lys Gln Gln Tyr Glu
                 660                 665                 670

 gac ctt gct tta gaa atc ttc acc aaa cat act tca aaa gat aac aga     2243
 Asp Leu Ala Leu Glu Ile Phe Thr Lys His Thr Ser Lys Asp Asn Arg
             675                 680                 685

 aaa cct gaa ttg gac agc ctt atg gaa ggt gga gaa ggg aaa ctg cca     2291
 Lys Pro Glu Leu Asp Ser Leu Met Glu Gly Gly Glu Gly Lys Leu Pro
         690                 695                 700

 aca tgc gtt gcc aca gga agc cca atc act gag tat caa ttc tgg atg     2339
 Thr Cys Val Ala Thr Gly Ser Pro Ile Thr Glu Tyr Gln Phe Trp Met
     705                 710                 715

 tgc agt gta tgc aaa cac ggt gtc ctt gct cag gaa ata agc cac tac     2387
 Cys Ser Val Cys Lys His Gly Val Leu Ala Gln Glu Ile Ser His Tyr
 720                 725                 730                 735

 agc ttc tgc ccc tta tgc cat agt cca gtg gga taa agga atgataaact     2437
 Ser Phe Cys Pro Leu Cys His Ser Pro Val Gly 
                 740                 745

 gtatataact gtaaaatata tgtagcatat atacatggct atatgctgta tatgtaataa   2497

 ggtttatttc tgtgagtttt gtatgaaaat cagcctcatt atttatagtt gaatttttgc   2557

 acaaaatata tgttaataaa ataattttta tggcaataca actgtgaaat aataaggccg   2617

 attttcatat aaatgtatga aaatcaacca tgttttatct caccctctct cttttgttta   2677

 tcttgttttt ggttacatga taccatggaa atattccaaa taaatttttt tctcacaaaa   2737

 aaaaaaaa                                                            2745




      <210> 81
      <211> 799
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(473)

      <400> 81
 gtaacgtcat tcatccacat taactaattt cctcactcca agctcttttc   atg gag      56
                                                          Met Glu
                                                            1

 ata atc tcc agt ccc tgt gca gaa act gtc att gca ctt tct gct gaa      104
 Ile Ile Ser Ser Pro Cys Ala Glu Thr Val Ile Ala Leu Ser Ala Glu
           5                  10                  15

 atg gca gtt tct tct cag caa ggt gag att atg gaa tcc aga atc ttt      152
 Met Ala Val Ser Ser Gln Gln Gly Glu Ile Met Glu Ser Arg Ile Phe
      20                  25                  30

 ttt cag ggg tca cat gcc cat ttc ccc act tgc atg aat gtc gac act      200
 Phe Gln Gly Ser His Ala His Phe Pro Thr Cys Met Asn Val Asp Thr
  35                  40                  45                  50

 gca gcc aca gtt ttg gcc gta aat gtg aat ttg gca agt aac cac tgt      248
 Ala Ala Thr Val Leu Ala Val Asn Val Asn Leu Ala Ser Asn His Cys
                  55                  60                  65

 tcc cag gga aat gtc cca atc aga aga aga tta tct ggg aca ctg ata      296
 Ser Gln Gly Asn Val Pro Ile Arg Arg Arg Leu Ser Gly Thr Leu Ile
              70                  75                  80

 ctg aca ggg aga tgg gac att ctg agg gac ccg gag gca ggg tgc cac      344
 Leu Thr Gly Arg Trp Asp Ile Leu Arg Asp Pro Glu Ala Gly Cys His
          85                  90                  95

 ctc ctc aac ttc cct gag ggc tgc cta gaa tct gtt tcc tct cac tct      392
 Leu Leu Asn Phe Pro Glu Gly Cys Leu Glu Ser Val Ser Ser His Ser
     100                 105                 110

 gaa tta ttc ttc ctc tta tgg ctg acc aaa aac atg gaa cct cac aaa      440
 Glu Leu Phe Phe Leu Leu Trp Leu Thr Lys Asn Met Glu Pro His Lys
 115                 120                 125                 130

 gtc cac tgt aac agc ttt ata ttt gtg aag tga agaacatg aagacagttt      491
 Val His Cys Asn Ser Phe Ile Phe Val Lys 
                 135                 140

 caagcaaagt tattgagtgg acactttgtg ttttttttga gaagtctcgc tctttcaccc    551

 aggctggagt gcagtggcac gatctcggct cactgcaact ccgcctcccg ggttcacgcc    611

 attctcttgc ctcagcctcc tgagtagctg ggaccacaag cgcccaccac gtcagcttaa    671

 tttttttgtt ttgtttcttg agacagagtc ttgctctctt gcccaggttg gagtgccgtg    731

 tcgcaatctc agctcactgc aacttctacc tcctggattc aagcacttct ccttgcatca    791

 gcctgtta                                                             799




      <210> 82
      <211> 1708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (132)..(620)

      <400> 82
 gcacgagctc tggattaggc aggcagaggc agttatgggc ttctgcagtg gcgagaaagg     60

 aagcgcctga agggtcgtga ggctggggcg ggacccggca ccgctggggc ggccaggccg    120

 tgaggacgcc a atg gcg agc agc gtg gac gag gag gcg ctg cac cag ctg     170
              Met Ala Ser Ser Val Asp Glu Glu Ala Leu His Gln Leu
                1               5                  10

 tac ctg tgg gta gac aac atc cct ctg tcc cgg ccc aag cga aac ctc      218
 Tyr Leu Trp Val Asp Asn Ile Pro Leu Ser Arg Pro Lys Arg Asn Leu
      15                  20                  25

 tcc cgg gac ttt agc gat gga gtc ctt gtt gca gag gtc atc aag ttt      266
 Ser Arg Asp Phe Ser Asp Gly Val Leu Val Ala Glu Val Ile Lys Phe
  30                  35                  40                  45

 tac ttc ccc aag atg gtg gag atg cac aat tat gtc ccc gcc aac tct      314
 Tyr Phe Pro Lys Met Val Glu Met His Asn Tyr Val Pro Ala Asn Ser
                  50                  55                  60

 ctc cag cag aag ctc agc aac tgg ggt cat ctg aac agg aag gta ctg      362
 Leu Gln Gln Lys Leu Ser Asn Trp Gly His Leu Asn Arg Lys Val Leu
              65                  70                  75

 aag agg ctg aac ttt tca gta ccg gat gac gtg atg cgc aag atc gcg      410
 Lys Arg Leu Asn Phe Ser Val Pro Asp Asp Val Met Arg Lys Ile Ala
          80                  85                  90

 cag tgc gcc cca ggc gtg gtg gag ctg gtg ctc atc ccg ctg agg cag      458
 Gln Cys Ala Pro Gly Val Val Glu Leu Val Leu Ile Pro Leu Arg Gln
      95                 100                 105

 cgc ctg gag gag agg cag agg cgc agg aag cag ggc gcc ggc tcc tta      506
 Arg Leu Glu Glu Arg Gln Arg Arg Arg Lys Gln Gly Ala Gly Ser Leu
 110                 115                 120                 125

 cag gag ctg gct ccc cag gat ggc agt ggc tac atg gat gtg ggt aag      554
 Gln Glu Leu Ala Pro Gln Asp Gly Ser Gly Tyr Met Asp Val Gly Lys
                 130                 135                 140

 gtg gcc ttt tcc att tct ccc tcc cgg ttg gag ctt tcc ttc tgt cct      602
 Val Ala Phe Ser Ile Ser Pro Ser Arg Leu Glu Leu Ser Phe Cys Pro
             145                 150                 155

 tct tcc tgt cac ttg taa gagtgg aagtagggag ggggaagcag gagaatgaga      656
 Ser Ser Cys His Leu 
         160

 ctccagcaca gtcattcctc cacttgcctt gtctcaggtg tatcccagaa ggcccgaggt    716

 gaaggtgtcc cggaccccca gggagggggt cagctcagct gggaccggcc gccggcgcct    776

 cggcctccag cgtataaccg ggcgttgcag ggcgacccca gcttcgtcct ccagatcgct    836

 gaaaaggagc aggagctgtt ggcctctcaa gagaccgtgc aggtcctgca gatgaaggta    896

 aggcgcctgg agcacctgct ccagctcaag aatgtgcgga tcgaagacct ctcccggcgg    956

 ctccagcagg cggagcgtaa gcagcggtga gcggcggccc gggccgcgcg gggacgcccg   1016

 ggtacccgcc agagccccga cgccgcgccg gacccaccca ccgatggata gaccattggg   1076

 agggcggagc ccgctgctct cacgagcctg ctggggcccg agtgccctcc ttccttggga   1136

 tgggtgagcg tgggaggaga tgggacagga actctaggag cgcaggcccg ggactgagcc   1196

 gcctcctacc actccggaga tccgggtcag gagaatggac cgctttccag agcccagaag   1256

 ccacgtgcag agacctagcc tgtcccccaa agcagtgtcc aacaccttgg gcccggcctt   1316

 gcatctcccg gcgctgggcc ttggggggcg gtcccttggc tctgtccaca cccccagaat   1376

 caggtccccg cccagctccg aggacggcgg cgtctccatc caggctagtt ccccatgccc   1436

 tcagccatgg gggaatctgt cccgggccgc tgaggggctc ccctgcccct cctgggagct   1496

 tacctgggac ccacctcggc gacggagacc gcagcagctg gagaggaagg ggtgaggcgt   1556

 gggatcgcca ggagtaggga ggacatcgac gatgtgcccg tagcagtcgc ccctccctcc   1616

 tcgcgcacgg ggtactgagg cggaaggttt gaaggttacg gctcagggct gccccattaa   1676

 agtcagtgtt gtgttctaaa aaaaaaaaaa aa                                 1708




      <210> 83
      <211> 1051
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (64)..(915)

      <400> 83
 tttcgtgccg cgggcggcgg cggcagcggt tggaggttgt aggaccggcg aggaatagga     60

 atc  atg gcg gct gcg ctg ttc gtg ctg ctg gga ttc gcg ctg ctg ggc     108
      Met Ala Ala Ala Leu Phe Val Leu Leu Gly Phe Ala Leu Leu Gly
        1               5                  10                  15

 acc cac gga gcc tcc ggg gct gcc ggc aca gtc ttc act acc gta gaa      156
 Thr His Gly Ala Ser Gly Ala Ala Gly Thr Val Phe Thr Thr Val Glu
                  20                  25                  30

 gac ctt ggc tcc aag ata ctc ctc acc tgc tcc ttg aat gac agc gcc      204
 Asp Leu Gly Ser Lys Ile Leu Leu Thr Cys Ser Leu Asn Asp Ser Ala
              35                  40                  45

 aca gag gtc aca ggg cac cgc tgg ctg aag ggg ggc gtg gtg ctg aag      252
 Thr Glu Val Thr Gly His Arg Trp Leu Lys Gly Gly Val Val Leu Lys
          50                  55                  60

 gag gac gcg ctg ccc ggc cag aaa acg gag ttc aag gtg gac tcg gac      300
 Glu Asp Ala Leu Pro Gly Gln Lys Thr Glu Phe Lys Val Asp Ser Asp
      65                  70                  75

 gac cag tgg gga gag tac tcc tgc gtc ttc ctc ccc gag ccc atg ggc      348
 Asp Gln Trp Gly Glu Tyr Ser Cys Val Phe Leu Pro Glu Pro Met Gly
  80                  85                  90                  95

 acg gcc aac atc cag ctc cac ggg cct ccc aga gtg aag gcc gtg aag      396
 Thr Ala Asn Ile Gln Leu His Gly Pro Pro Arg Val Lys Ala Val Lys
                 100                 105                 110

 tcg tca gaa cac atc aac gag ggg gag acg gcc atg ctg gtc tgc aag      444
 Ser Ser Glu His Ile Asn Glu Gly Glu Thr Ala Met Leu Val Cys Lys
             115                 120                 125

 tca gag tcc gtg cca cct gtc act gac tgg gcc tgg tac aag atc act      492
 Ser Glu Ser Val Pro Pro Val Thr Asp Trp Ala Trp Tyr Lys Ile Thr
         130                 135                 140

 gac tct gag gac aag gcc ctc atg aac ggc tcc gag agc agg ttc ttc      540
 Asp Ser Glu Asp Lys Ala Leu Met Asn Gly Ser Glu Ser Arg Phe Phe
     145                 150                 155

 gtg agt tcc tcg cag ggc cgg tca gag cta cac att gag aac ctg aac      588
 Val Ser Ser Ser Gln Gly Arg Ser Glu Leu His Ile Glu Asn Leu Asn
 160                 165                 170                 175

 atg gag gcc gac ccc ggc cag tac cgg tgc aac ggc acc agc tcc aag      636
 Met Glu Ala Asp Pro Gly Gln Tyr Arg Cys Asn Gly Thr Ser Ser Lys
                 180                 185                 190

 ggc tcc gac cag gcc atc atc acg ctc cgc gtg cgc agc cac ctg gcc      684
 Gly Ser Asp Gln Ala Ile Ile Thr Leu Arg Val Arg Ser His Leu Ala
             195                 200                 205

 gcc ctc tgg ccc ttc ctg ggc atc gtg gct gag gtg ctg gtg ctg gtc      732
 Ala Leu Trp Pro Phe Leu Gly Ile Val Ala Glu Val Leu Val Leu Val
         210                 215                 220

 acc atc atc ttc atc tac gag aag cgc cgg aag ccc gag gac gtc ctg      780
 Thr Ile Ile Phe Ile Tyr Glu Lys Arg Arg Lys Pro Glu Asp Val Leu
     225                 230                 235

 gat gat gac gac gcc ggc tct gca ccc ctg aaa gct gtg gga aca cga      828
 Asp Asp Asp Asp Ala Gly Ser Ala Pro Leu Lys Ala Val Gly Thr Arg
 240                 245                 250                 255

 agt gca atg cta ccg tcg gcg aga agc cta cct gag gag ggg cag gaa      876
 Ser Ala Met Leu Pro Ser Ala Arg Ser Leu Pro Glu Glu Gly Gln Glu
                 260                 265                 270

 gac ccg atc cgt ttg gcg gcc gcc cag tac ccc agg tga cgaacaacgc       925
 Asp Pro Ile Arg Leu Ala Ala Ala Gln Tyr Pro Arg 
             275                 280

 gtgctccaaa gaggccccgg gtcccgacaa ctctccttaa gagggggctc ccacgggtgg    985

 gatcaaggga agacgggacg cccgttatgc ggggggatca accccacgtc cacgccccgt   1045

 ataagc                                                              1051




      <210> 84
      <211> 1144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (275)..(592)

      <400> 84
 cagcccattt tacagatggc ttttggcttg cccaagggga ccaccctctg aactgaggcg     60

 tccccaaccc atgccgggag ctggtggagg aagtggggaa gggtttcccg cttctccact    120

 gggggtggag gtgggagaaa gcattttcag ggtgttttga catttaacaa acagtatgca    180

 aatcacatgc aaatcgcatg caaatcacca cccatttctt aagcctcgac agcgctggca    240

 tgttctgaaa taataatgtt ggacctgtcc cttg    atg atg acc tgg gtc ggg     292
                                          Met Met Thr Trp Val Gly
                                            1               5

 agg tgc acg gcc ttt tcc ttc ctc cgt ctt ccc ttc cct tcc ctt ccc      340
 Arg Cys Thr Ala Phe Ser Phe Leu Arg Leu Pro Phe Pro Ser Leu Pro
              10                  15                  20

 ttc cca tct gtt ctc cct tcc ttc gcc ccc ttc ctt tcc tct ccc tcc      388
 Phe Pro Ser Val Leu Pro Ser Phe Ala Pro Phe Leu Ser Ser Pro Ser
          25                  30                  35

 cta tct tcc att ttt ctc ttc ttc ctt cac atc att tgt cca aga cct      436
 Leu Ser Ser Ile Phe Leu Phe Phe Leu His Ile Ile Cys Pro Arg Pro
      40                  45                  50

 ccc tgg cct gag ata aac ata agt tgc aaa agt ggc ttc ctg cag ccc      484
 Pro Trp Pro Glu Ile Asn Ile Ser Cys Lys Ser Gly Phe Leu Gln Pro
  55                  60                  65                  70

 att ttc cag gtt ggg aaa ctg agg cat ggg cct aag gtc cca cag cca      532
 Ile Phe Gln Val Gly Lys Leu Arg His Gly Pro Lys Val Pro Gln Pro
                  75                  80                  85

 cac cga gga aag cag ccc cca ctg aat gtc acc atg cac caa agt gca      580
 His Arg Gly Lys Gln Pro Pro Leu Asn Val Thr Met His Gln Ser Ala
              90                  95                 100

 tgg tcc tcg tga cac aaagagggga gatgacagtg gctggagttg tcagagctgc      635
 Trp Ser Ser 
         105

 tttgaggaag ctccaggcct gataggcttg acagggccaa ggggaactat tgtggaatgt    695

 cttggccttg aatgacaggc tgctgatttt ggatctggag aaagctcaca ctgactcttc    755

 ctgctccccc agtctgtttt tctcctgcta ctccatccat gtatccctga gtttgggcca    815

 cagtccctcc acttggtttg catgtcccac cttctttgtt tggcaagctc ctattcatcc    875

 ttcaaagccc tagcttcaat acctgctact tcatgcagcc attgcttatc cttcaaggag    935

 agcctacttc cctcaaggac cctgctgctt ccagtctcac cttctgactc actcgggatc    995

 cactgaactg ggaggtctgt gtctcctccc agcagagtca tcactacctt tggggccgca   1055

 ggatcaccca gcttggaact agatacagaa atgctgtttt gagagtgtac tgaataaaag   1115

 attacatgtt tgaaaacaaa aaaaaaaaa                                     1144




      <210> 85
      <211> 3382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (232)..(2949)

      <400> 85
 ggcagctccc aacccccgtc ctggacccac aaatcttctc gacccctggc ccaccccggc     60

 cgtcaccgag aacggtcccc tagggtgcct agggacttcc ggagcccgac cggatccgga    120

 agcttctgag agcgaggggg tggggccgaa aatcaaaaaa agcgcggcga aagctaaagg    180

 ccggcgcacg ctgggcggtg gtggtcccta agccgggccg cggccggtgc a atg gac     237
                                                          Met Asp
                                                            1

 tcc act gcc tgc ttg aag tcc ttg ctc ctg act gtc agt cag tac aaa      285
 Ser Thr Ala Cys Leu Lys Ser Leu Leu Leu Thr Val Ser Gln Tyr Lys
           5                  10                  15

 gcc gtg aag tca gag gcg aac gcc act cag ctt ttg cgg cac ttg gag      333
 Ala Val Lys Ser Glu Ala Asn Ala Thr Gln Leu Leu Arg His Leu Glu
      20                  25                  30

 gta att tct gga cag aaa ctc aca cga cta ttt aca tca aat cag ata      381
 Val Ile Ser Gly Gln Lys Leu Thr Arg Leu Phe Thr Ser Asn Gln Ile
  35                  40                  45                  50

 tta aca agt gaa tgc ttg agt tgc ctt gta gag cta ctt gaa gac ccc      429
 Leu Thr Ser Glu Cys Leu Ser Cys Leu Val Glu Leu Leu Glu Asp Pro
                  55                  60                  65

 aac ata agt gct tca ctg atc tta agt att atc ggt ttg ctg tct caa      477
 Asn Ile Ser Ala Ser Leu Ile Leu Ser Ile Ile Gly Leu Leu Ser Gln
              70                  75                  80

 cta gca gta gac att gaa acc aga gat tgt ctt cag aat aca tat aat      525
 Leu Ala Val Asp Ile Glu Thr Arg Asp Cys Leu Gln Asn Thr Tyr Asn
          85                  90                  95

 ctg aat agt gtg ctg gcg gga gtg gtt tgt cgg agc agc cac act gat      573
 Leu Asn Ser Val Leu Ala Gly Val Val Cys Arg Ser Ser His Thr Asp
     100                 105                 110

 tcg gtg ttt ttg cag tgc att caa ctt cta cag aag tta aca tat aat      621
 Ser Val Phe Leu Gln Cys Ile Gln Leu Leu Gln Lys Leu Thr Tyr Asn
 115                 120                 125                 130

 gtc aaa att ttc tat tct ggt gcc aat ata gat gaa tta att acg ttc      669
 Val Lys Ile Phe Tyr Ser Gly Ala Asn Ile Asp Glu Leu Ile Thr Phe
                 135                 140                 145

 ctg ata gat cac att caa tct tct gaa gat gag tta aaa atg cct tgt      717
 Leu Ile Asp His Ile Gln Ser Ser Glu Asp Glu Leu Lys Met Pro Cys
             150                 155                 160

 cta gga tta ttg gca aat ctt tgt cgg cac aat ctt tct gtt caa acg      765
 Leu Gly Leu Leu Ala Asn Leu Cys Arg His Asn Leu Ser Val Gln Thr
         165                 170                 175

 cac ata aag aca ttg agt aat gtg aaa tct ttt tat cga act ctt atc      813
 His Ile Lys Thr Leu Ser Asn Val Lys Ser Phe Tyr Arg Thr Leu Ile
     180                 185                 190

 acc ttg ttg gcc cat agt agt tta act gtg gtt gtg ttt gca ctt tca      861
 Thr Leu Leu Ala His Ser Ser Leu Thr Val Val Val Phe Ala Leu Ser
 195                 200                 205                 210

 ata tta tcc agt ttg aca tta aat gaa gag gtg ggg gaa aag cta ttc      909
 Ile Leu Ser Ser Leu Thr Leu Asn Glu Glu Val Gly Glu Lys Leu Phe
                 215                 220                 225

 cat gct cga aac att cat cag act ttt caa cta ata ttt aat att ctc      957
 His Ala Arg Asn Ile His Gln Thr Phe Gln Leu Ile Phe Asn Ile Leu
             230                 235                 240

 ata aac ggt gat ggc act cta act aga aag tat tca gtt gac cta ctg     1005
 Ile Asn Gly Asp Gly Thr Leu Thr Arg Lys Tyr Ser Val Asp Leu Leu
         245                 250                 255

 atg gat ctc ctt aag aat cct aaa att gct gat tat ctc acc aga tat     1053
 Met Asp Leu Leu Lys Asn Pro Lys Ile Ala Asp Tyr Leu Thr Arg Tyr
     260                 265                 270

 gag cac ttt tct tca tgt ctt cac caa gta tta ggt ctt ctt aat gga     1101
 Glu His Phe Ser Ser Cys Leu His Gln Val Leu Gly Leu Leu Asn Gly
 275                 280                 285                 290

 aag gat cct gat tcc tct tca aag gtt tta gaa tta ctt ctt gcc ttc     1149
 Lys Asp Pro Asp Ser Ser Ser Lys Val Leu Glu Leu Leu Leu Ala Phe
                 295                 300                 305

 tgt tca gtg act cag ctg cgc cat atg ctc act cag atg atg ttt gaa     1197
 Cys Ser Val Thr Gln Leu Arg His Met Leu Thr Gln Met Met Phe Glu
             310                 315                 320

 cag tct cca cct ggc agc gcc act ctg gga agc cat act aaa tgt tta     1245
 Gln Ser Pro Pro Gly Ser Ala Thr Leu Gly Ser His Thr Lys Cys Leu
         325                 330                 335

 gaa cct act gtg gct cta ctg cgc tgg tta agc caa cct ttg gac gga     1293
 Glu Pro Thr Val Ala Leu Leu Arg Trp Leu Ser Gln Pro Leu Asp Gly
     340                 345                 350

 tca gaa aac tgt tct gtt tta gca ttg gag ttg ttc aag gaa ata ttt     1341
 Ser Glu Asn Cys Ser Val Leu Ala Leu Glu Leu Phe Lys Glu Ile Phe
 355                 360                 365                 370

 gag gat gtc ata gat gct gct aac tgt tcc tcg gct gat cgt ttt gtg     1389
 Glu Asp Val Ile Asp Ala Ala Asn Cys Ser Ser Ala Asp Arg Phe Val
                 375                 380                 385

 acc ctt ctg ctg cct aca atc ctt gat caa ctt cag ttc aca gaa caa     1437
 Thr Leu Leu Leu Pro Thr Ile Leu Asp Gln Leu Gln Phe Thr Glu Gln
             390                 395                 400

 aat cta gat gag gct tta aca aga aaa aaa tgt gaa agg att gcc aag     1485
 Asn Leu Asp Glu Ala Leu Thr Arg Lys Lys Cys Glu Arg Ile Ala Lys
         405                 410                 415

 gcc att gaa gtt ttg tta act ctc tgt gga gat gat aca cta aaa atg     1533
 Ala Ile Glu Val Leu Leu Thr Leu Cys Gly Asp Asp Thr Leu Lys Met
     420                 425                 430

 cat att gca aaa atc ttg aca act gtc aag tgt acc act ctt ata gaa     1581
 His Ile Ala Lys Ile Leu Thr Thr Val Lys Cys Thr Thr Leu Ile Glu
 435                 440                 445                 450

 caa caa ttt aca tat ggc aag att gac ctg gga ttt gga aca aag gtt     1629
 Gln Gln Phe Thr Tyr Gly Lys Ile Asp Leu Gly Phe Gly Thr Lys Val
                 455                 460                 465

 gca gat tct gaa tta tgc aaa ctt gct gct gat gta att ttg aaa act     1677
 Ala Asp Ser Glu Leu Cys Lys Leu Ala Ala Asp Val Ile Leu Lys Thr
             470                 475                 480

 ctt gat ttg att aac aaa ctt aaa cca ttg gtt cct ggt atg gaa gta     1725
 Leu Asp Leu Ile Asn Lys Leu Lys Pro Leu Val Pro Gly Met Glu Val
         485                 490                 495

 agc ttc tac aaa ata ctt cag gac cca cgt ttg att act cct ttg gct     1773
 Ser Phe Tyr Lys Ile Leu Gln Asp Pro Arg Leu Ile Thr Pro Leu Ala
     500                 505                 510

 ttt gct tta acg tca gat aat aga gaa caa gta cag tct gga ctg aga     1821
 Phe Ala Leu Thr Ser Asp Asn Arg Glu Gln Val Gln Ser Gly Leu Arg
 515                 520                 525                 530

 ata tta ttg gag gct gct cca ctg cca gat ttt cct gct tta gta ctt     1869
 Ile Leu Leu Glu Ala Ala Pro Leu Pro Asp Phe Pro Ala Leu Val Leu
                 535                 540                 545

 gga gaa agt ata gca gca aac aat gcc tat aga caa cag gaa aca gaa     1917
 Gly Glu Ser Ile Ala Ala Asn Asn Ala Tyr Arg Gln Gln Glu Thr Glu
             550                 555                 560

 cat ata ccc aga aaa atg ccc tgg caa tca tca aat cac agt ttt cca     1965
 His Ile Pro Arg Lys Met Pro Trp Gln Ser Ser Asn His Ser Phe Pro
         565                 570                 575

 aca tca ata aag tgt tta act cct cat ttg aaa gat ggt gtt cct gga     2013
 Thr Ser Ile Lys Cys Leu Thr Pro His Leu Lys Asp Gly Val Pro Gly
     580                 585                 590

 ttg aat att gaa gaa tta ata gag aaa ctt cag tct gga atg gtg gta     2061
 Leu Asn Ile Glu Glu Leu Ile Glu Lys Leu Gln Ser Gly Met Val Val
 595                 600                 605                 610

 aag gat cag att tgt gat gtg aga ata tct gac ata atg gat gta tat     2109
 Lys Asp Gln Ile Cys Asp Val Arg Ile Ser Asp Ile Met Asp Val Tyr
                 615                 620                 625

 gaa atg aaa cta tcc aca tta gct tcc aaa gaa agc agg cta caa gat     2157
 Glu Met Lys Leu Ser Thr Leu Ala Ser Lys Glu Ser Arg Leu Gln Asp
             630                 635                 640

 ctt ttg gaa aca aaa gct cta gcc ctt gca cag gct gat aga ctg att     2205
 Leu Leu Glu Thr Lys Ala Leu Ala Leu Ala Gln Ala Asp Arg Leu Ile
         645                 650                 655

 gct cag cat cgc tgt caa aga act caa gct gaa aca gag gca cgg aca     2253
 Ala Gln His Arg Cys Gln Arg Thr Gln Ala Glu Thr Glu Ala Arg Thr
     660                 665                 670

 ctt gct agt atg ttg aga gaa gtt gag aga aaa aat gaa gag ctt agt     2301
 Leu Ala Ser Met Leu Arg Glu Val Glu Arg Lys Asn Glu Glu Leu Ser
 675                 680                 685                 690

 gtg ttg ctg aag gcg cag caa gtt gaa tca gaa aga gcg cag agt gat     2349
 Val Leu Leu Lys Ala Gln Gln Val Glu Ser Glu Arg Ala Gln Ser Asp
                 695                 700                 705

 att gag cat ctc ttt caa cat aat agg aag tta gag tct gtg gct gaa     2397
 Ile Glu His Leu Phe Gln His Asn Arg Lys Leu Glu Ser Val Ala Glu
             710                 715                 720

 gaa cat gaa ata ctg aca aaa tcc tac atg gaa ctt ctt cag aga aat     2445
 Glu His Glu Ile Leu Thr Lys Ser Tyr Met Glu Leu Leu Gln Arg Asn
         725                 730                 735

 gaa agt act gaa aag aag aat aaa gat tta cag atc aca tgt gat tct     2493
 Glu Ser Thr Glu Lys Lys Asn Lys Asp Leu Gln Ile Thr Cys Asp Ser
     740                 745                 750

 ctg aat aaa caa att gag aca gtg aaa aag ttg aat gag tca ctc aag     2541
 Leu Asn Lys Gln Ile Glu Thr Val Lys Lys Leu Asn Glu Ser Leu Lys
 755                 760                 765                 770

 gaa caa aat gaa aaa agt att gcc caa tta ata gag aaa gaa gaa cag     2589
 Glu Gln Asn Glu Lys Ser Ile Ala Gln Leu Ile Glu Lys Glu Glu Gln
                 775                 780                 785

 aga aaa gaa gta cag aat cag cta gta gac aga gaa cat aag cta gca     2637
 Arg Lys Glu Val Gln Asn Gln Leu Val Asp Arg Glu His Lys Leu Ala
             790                 795                 800

 aat ttg cat caa aaa aca aaa gta caa gaa gaa aag att aaa acc tta     2685
 Asn Leu His Gln Lys Thr Lys Val Gln Glu Glu Lys Ile Lys Thr Leu
         805                 810                 815

 caa aag gaa agg gaa gat aag gaa gaa acc att gat atc ctt aga aaa     2733
 Gln Lys Glu Arg Glu Asp Lys Glu Glu Thr Ile Asp Ile Leu Arg Lys
     820                 825                 830

 gaa tta agc aga aca gaa cag ata aga aaa gag ttg agc att aag gct     2781
 Glu Leu Ser Arg Thr Glu Gln Ile Arg Lys Glu Leu Ser Ile Lys Ala
 835                 840                 845                 850

 tcc tcc cta gag gtt caa aag gca caa tta gaa ggt cgt ttg gaa gag     2829
 Ser Ser Leu Glu Val Gln Lys Ala Gln Leu Glu Gly Arg Leu Glu Glu
                 855                 860                 865

 aaa gag tcc ttg gtg aaa ctt cag caa gag gaa ttg aac aaa cac tcc     2877
 Lys Glu Ser Leu Val Lys Leu Gln Gln Glu Glu Leu Asn Lys His Ser
             870                 875                 880

 cac atg ata gca atg atc cac agt tta agt ggt gga aaa ata aat cca     2925
 His Met Ile Ala Met Ile His Ser Leu Ser Gly Gly Lys Ile Asn Pro
         885                 890                 895

 gaa act gtg aat ctc agt ata tag acattatggc attttggaat ttgtaatctc    2979
 Glu Thr Val Asn Leu Ser Ile 
     900                 905

 atgatatttt tgatgtattt atctattgga gggggggtgg gtaggggagt taatttgtga   3039

 cttcgtaaca ataagaagtt attatctaat ttagtaaaga ccctgatctg ttgcatgttt   3099

 tttatttgat agtttgaata gaaatttaat tttctaagtt ttactttttg tttctggctt   3159

 ttatggctta aggttttctt tggttcttac attagaaaat catttttaac ctccattatc   3219

 atttttctaa ggttctttcc tttttcttag ttgctttcta ttctgttttg cctgtcttat   3279

 ttattctcat ttgtgattat ttagatctta agaccaaact ttcttggtat aacagtccta   3339

 aagattacaa aataaaaata tagagagagt aaaagtaaaa agt                     3382




      <210> 86
      <211> 4166
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3465)

      <400> 86
  atg gtg act ccc aga att gtc tgc ctg gac agt gtc cag agc act ggt      48
  Met Val Thr Pro Arg Ile Val Cys Leu Asp Ser Val Gln Ser Thr Gly
    1               5                  10                  15

 tcc acc tta gcc gct gcc aga gtc acg ttt ggg cca tgg gat aca agg       96
 Ser Thr Leu Ala Ala Ala Arg Val Thr Phe Gly Pro Trp Asp Thr Arg
              20                  25                  30

 aga acc cca ctg tcc ctg gct gag ggg agg acc aga gcc tgc act cag      144
 Arg Thr Pro Leu Ser Leu Ala Glu Gly Arg Thr Arg Ala Cys Thr Gln
          35                  40                  45

 cgc aga ttt gag gct ggt gtg gtc cag tgg gtt gaa ggt aac gag tct      192
 Arg Arg Phe Glu Ala Gly Val Val Gln Trp Val Glu Gly Asn Glu Ser
      50                  55                  60

 gac ctt gaa cta gaa aag aag tgt aag gaa gat gat cgg gaa aaa gcc      240
 Asp Leu Glu Leu Glu Lys Lys Cys Lys Glu Asp Asp Arg Glu Lys Ala
  65                  70                  75                  80

 tcg aaa aga cca cgg tca cag aaa aca gag aaa gtc cag aag atc tca      288
 Ser Lys Arg Pro Arg Ser Gln Lys Thr Glu Lys Val Gln Lys Ile Ser
                  85                  90                  95

 gga aag gag gcc aga cag ctt tct ggg gcg aag aaa ccc atc ata agt      336
 Gly Lys Glu Ala Arg Gln Leu Ser Gly Ala Lys Lys Pro Ile Ile Ser
             100                 105                 110

 gtg gtt tta act gca cac gaa gca att cca ggt gct acc aag att gtg      384
 Val Val Leu Thr Ala His Glu Ala Ile Pro Gly Ala Thr Lys Ile Val
         115                 120                 125

 cca gtg gag gct ggg ccc cct gaa aca gga gct aca aat tct gag acc      432
 Pro Val Glu Ala Gly Pro Pro Glu Thr Gly Ala Thr Asn Ser Glu Thr
     130                 135                 140

 act tca gca gac ctg gtg cct cgg aga ggc tac cag gaa tac gcc att      480
 Thr Ser Ala Asp Leu Val Pro Arg Arg Gly Tyr Gln Glu Tyr Ala Ile
 145                 150                 155                 160

 cag cag aca cct tat gag caa cca atg aag tca agc agg cta ggt ccc      528
 Gln Gln Thr Pro Tyr Glu Gln Pro Met Lys Ser Ser Arg Leu Gly Pro
                 165                 170                 175

 act cag ctc aaa atc ttc act tgt gaa tac tgc aac aag gtc ttc aag      576
 Thr Gln Leu Lys Ile Phe Thr Cys Glu Tyr Cys Asn Lys Val Phe Lys
             180                 185                 190

 ttc aag cac tcg ctg cag gcc cac ctg agg atc cac acc aat gaa aag      624
 Phe Lys His Ser Leu Gln Ala His Leu Arg Ile His Thr Asn Glu Lys
         195                 200                 205

 cca tac aag tgc ccc cag tgc agc tat gcc agt gcc atc aag gcc aac      672
 Pro Tyr Lys Cys Pro Gln Cys Ser Tyr Ala Ser Ala Ile Lys Ala Asn
     210                 215                 220

 ctc aat gtg cac ctg cgc aag cac act gga gag aag ttc gcc tgc gac      720
 Leu Asn Val His Leu Arg Lys His Thr Gly Glu Lys Phe Ala Cys Asp
 225                 230                 235                 240

 tac tgc tcg ttc acc tgc ctg agc aag ggc cac ctc aag gtg cac atc      768
 Tyr Cys Ser Phe Thr Cys Leu Ser Lys Gly His Leu Lys Val His Ile
                 245                 250                 255

 gag cga gtg cac aag aag atc aag cag cac tgc cgc ttc tgc aag aag      816
 Glu Arg Val His Lys Lys Ile Lys Gln His Cys Arg Phe Cys Lys Lys
             260                 265                 270

 aag tac tct gac gtc aag aac ctc atc aag cac atc cga gac gcg cat      864
 Lys Tyr Ser Asp Val Lys Asn Leu Ile Lys His Ile Arg Asp Ala His
         275                 280                 285

 gac cca cag gac aag aag gtc aaa gag gcc ttg gac gag ctc tgc ctg      912
 Asp Pro Gln Asp Lys Lys Val Lys Glu Ala Leu Asp Glu Leu Cys Leu
     290                 295                 300

 atg acg agg gag ggc aag cgg cag ctg ctc tat gac tgc cac atc tgt      960
 Met Thr Arg Glu Gly Lys Arg Gln Leu Leu Tyr Asp Cys His Ile Cys
 305                 310                 315                 320

 gag cgc aag ttc aag aac gag ctg gac cgc gac cgc cat atg ctg gtc     1008
 Glu Arg Lys Phe Lys Asn Glu Leu Asp Arg Asp Arg His Met Leu Val
                 325                 330                 335

 cac gga gac aag tgg cct ttt gcc tgt gag ctc tgt ggc cat ggg gcc     1056
 His Gly Asp Lys Trp Pro Phe Ala Cys Glu Leu Cys Gly His Gly Ala
             340                 345                 350

 acc aag tac cag gcg ctg gaa ctg cat gtc agg aag cac ccc ttc gtg     1104
 Thr Lys Tyr Gln Ala Leu Glu Leu His Val Arg Lys His Pro Phe Val
         355                 360                 365

 tac gtc tgt gcc gtc tgc cgc aag aag ttc gtc agc tcc atc agg ctg     1152
 Tyr Val Cys Ala Val Cys Arg Lys Lys Phe Val Ser Ser Ile Arg Leu
     370                 375                 380

 cgc acc cac atc aaa gag gtg cac ggg gct gcc cag gag gcc ttg gtc     1200
 Arg Thr His Ile Lys Glu Val His Gly Ala Ala Gln Glu Ala Leu Val
 385                 390                 395                 400

 ttc acc agt tcc atc aac cag agc ttc tgc ctc ctg gaa cct ggt ggg     1248
 Phe Thr Ser Ser Ile Asn Gln Ser Phe Cys Leu Leu Glu Pro Gly Gly
                 405                 410                 415

 gac atc cag caa gaa gct ctg ggg gac cag cta cag ctg gtg gaa gag     1296
 Asp Ile Gln Gln Glu Ala Leu Gly Asp Gln Leu Gln Leu Val Glu Glu
             420                 425                 430

 gag ttt gcc ctc cag ggc gtg aat gca ctc aag gaa gag gcc tgt cct     1344
 Glu Phe Ala Leu Gln Gly Val Asn Ala Leu Lys Glu Glu Ala Cys Pro
         435                 440                 445

 ggg gac act cag ctg gag gag ggc cgg aag gag ccg gag gcc cct ggg     1392
 Gly Asp Thr Gln Leu Glu Glu Gly Arg Lys Glu Pro Glu Ala Pro Gly
     450                 455                 460

 gaa atg cct gcc cca gct gtg cac ctg gcc tcc ccg cag gcc gaa agc     1440
 Glu Met Pro Ala Pro Ala Val His Leu Ala Ser Pro Gln Ala Glu Ser
 465                 470                 475                 480

 aca gcc ctg cca ccc tgt gag ctg gaa acc acc gtg gtc tcc tcc tca     1488
 Thr Ala Leu Pro Pro Cys Glu Leu Glu Thr Thr Val Val Ser Ser Ser
                 485                 490                 495

 gac ccg cat tct caa gag gtg gtt tca gat gat ttt ttg ttg aaa aag     1536
 Asp Pro His Ser Gln Glu Val Val Ser Asp Asp Phe Leu Leu Lys Lys
             500                 505                 510

 gat acc tcc tcc gca gag gct cat gct gct cct gag aag ccc cca gac     1584
 Asp Thr Ser Ser Ala Glu Ala His Ala Ala Pro Glu Lys Pro Pro Asp
         515                 520                 525

 atg cag cac aga agc tca gtc cag acg caa ggt gaa gtg atc aca cta     1632
 Met Gln His Arg Ser Ser Val Gln Thr Gln Gly Glu Val Ile Thr Leu
     530                 535                 540

 ctg ctg tcc aag gcc cag agt gct ggg tca gat cag gaa agc cat ggc     1680
 Leu Leu Ser Lys Ala Gln Ser Ala Gly Ser Asp Gln Glu Ser His Gly
 545                 550                 555                 560

 gcc cag agc ccc cta ggg gaa ggg cag aac atg gct gtg ctt tca gct     1728
 Ala Gln Ser Pro Leu Gly Glu Gly Gln Asn Met Ala Val Leu Ser Ala
                 565                 570                 575

 ggt gac cca gat ccc agc agg tgt ctc agg tca aac cca gct gag gcc     1776
 Gly Asp Pro Asp Pro Ser Arg Cys Leu Arg Ser Asn Pro Ala Glu Ala
             580                 585                 590

 tca gac ctc ctc cct cca gta gct ggt ggt ggg gac acc atc aca cat     1824
 Ser Asp Leu Leu Pro Pro Val Ala Gly Gly Gly Asp Thr Ile Thr His
         595                 600                 605

 cag cct gac tct tgc aaa gct gcc cct gag cac cgg tca ggc atc acc     1872
 Gln Pro Asp Ser Cys Lys Ala Ala Pro Glu His Arg Ser Gly Ile Thr
     610                 615                 620

 gct ttc atg aag gtc ctg aac agt tta cag aag aag caa atg aac acc     1920
 Ala Phe Met Lys Val Leu Asn Ser Leu Gln Lys Lys Gln Met Asn Thr
 625                 630                 635                 640

 agc ttg tgt gag cgg atc cgg aag gtt tat gga gac ctg gag tgt gaa     1968
 Ser Leu Cys Glu Arg Ile Arg Lys Val Tyr Gly Asp Leu Glu Cys Glu
                 645                 650                 655

 tac tgt ggc aaa ctt ttt tgg tac caa gtg cat ttt gat atg cat gtc     2016
 Tyr Cys Gly Lys Leu Phe Trp Tyr Gln Val His Phe Asp Met His Val
             660                 665                 670

 cgc acc cac acc cgg gaa cat ctg tat tat tgc tct cag tgt cat tat     2064
 Arg Thr His Thr Arg Glu His Leu Tyr Tyr Cys Ser Gln Cys His Tyr
         675                 680                 685

 tct tcc atc acc aaa aac tgc ctt aaa cgc cac gta att cag aaa cac     2112
 Ser Ser Ile Thr Lys Asn Cys Leu Lys Arg His Val Ile Gln Lys His
     690                 695                 700

 agt aac atc ttg ctg aag tgt ccc acc gac ggc tgt gac tac tca act     2160
 Ser Asn Ile Leu Leu Lys Cys Pro Thr Asp Gly Cys Asp Tyr Ser Thr
 705                 710                 715                 720

 cca gat aaa tat aag cta cag gca cat ctt aaa gtt cac aca gca ctg     2208
 Pro Asp Lys Tyr Lys Leu Gln Ala His Leu Lys Val His Thr Ala Leu
                 725                 730                 735

 gac aaa agg agt tat tct tgt cct gtt tgt gaa aag tct ttt tca gag     2256
 Asp Lys Arg Ser Tyr Ser Cys Pro Val Cys Glu Lys Ser Phe Ser Glu
             740                 745                 750

 gat cga ttg ata aag tca cat atc aag acc aac cat cct gag gtc tcc     2304
 Asp Arg Leu Ile Lys Ser His Ile Lys Thr Asn His Pro Glu Val Ser
         755                 760                 765

 atg agc acc att tct gag gtt ctc ggg agg agg gtt cag ctg aaa ggg     2352
 Met Ser Thr Ile Ser Glu Val Leu Gly Arg Arg Val Gln Leu Lys Gly
     770                 775                 780

 cta att gga aag aga gcc atg aaa tgc cca tat tgt gac ttt tat ttc     2400
 Leu Ile Gly Lys Arg Ala Met Lys Cys Pro Tyr Cys Asp Phe Tyr Phe
 785                 790                 795                 800

 atg aag aat ggc tca gac ctt cag cgt cat att tgg gct cat gaa ggt     2448
 Met Lys Asn Gly Ser Asp Leu Gln Arg His Ile Trp Ala His Glu Gly
                 805                 810                 815

 gtg aag ccc ttc aag tgt tct ttg tgt gag tat gca act cgt agc aag     2496
 Val Lys Pro Phe Lys Cys Ser Leu Cys Glu Tyr Ala Thr Arg Ser Lys
             820                 825                 830

 agt aac ctc aag gct cat atg aat cgt cac agc act gag aaa acc cac     2544
 Ser Asn Leu Lys Ala His Met Asn Arg His Ser Thr Glu Lys Thr His
         835                 840                 845

 cta tgt gac atg tgt ggc aag aaa ttc aaa tca aaa ggg aca ctg aaa     2592
 Leu Cys Asp Met Cys Gly Lys Lys Phe Lys Ser Lys Gly Thr Leu Lys
     850                 855                 860

 agt cac aaa ctc ctt cac act gca gat ggg aag cag ttt aag tgc acg     2640
 Ser His Lys Leu Leu His Thr Ala Asp Gly Lys Gln Phe Lys Cys Thr
 865                 870                 875                 880

 gtg tgt gac tac aca gcg gcc cag aag cca cag ctg ctg cgg cac atg     2688
 Val Cys Asp Tyr Thr Ala Ala Gln Lys Pro Gln Leu Leu Arg His Met
                 885                 890                 895

 gaa cag cat gtc tcc ttc aag cct ttc cgc tgt gcc cat tgc cat tac     2736
 Glu Gln His Val Ser Phe Lys Pro Phe Arg Cys Ala His Cys His Tyr
             900                 905                 910

 tcc tgc aac ata tct ggc tct ctg aag cgg cac tac aac agg aag cac     2784
 Ser Cys Asn Ile Ser Gly Ser Leu Lys Arg His Tyr Asn Arg Lys His
         915                 920                 925

 cct aat gag gag tat gcc aac gtg ggc acc ggg gag ctg gca gcg gag     2832
 Pro Asn Glu Glu Tyr Ala Asn Val Gly Thr Gly Glu Leu Ala Ala Glu
     930                 935                 940

 gtg ctc atc cag caa ggt ggt ttg aag tgt cct gtt tgc agc ttt gta     2880
 Val Leu Ile Gln Gln Gly Gly Leu Lys Cys Pro Val Cys Ser Phe Val
 945                 950                 955                 960

 tat ggc acc aaa tgg gag ttc aat agg cac ttg aag aac aaa cat ggc     2928
 Tyr Gly Thr Lys Trp Glu Phe Asn Arg His Leu Lys Asn Lys His Gly
                 965                 970                 975

 ttg aag gtg gtg gaa att gat gga gac ccc aag tgg gag aca gca aca     2976
 Leu Lys Val Val Glu Ile Asp Gly Asp Pro Lys Trp Glu Thr Ala Thr
             980                 985                 990

 gaa gct cct gag gag ccc tcc acc cag tat ctc cac atc aca gag gcc     3024
 Glu Ala Pro Glu Glu Pro Ser Thr Gln Tyr Leu His Ile Thr Glu Ala
         995                1000                1005

 gaa gaa gac gtt caa ggg aca cag gca gcg gtg gcc gcg ctc cag gac     3072
 Glu Glu Asp Val Gln Gly Thr Gln Ala Ala Val Ala Ala Leu Gln Asp
    1010                1015                1020

 ctg aga tac acc tct gag agt ggc gac cga ctg gac ccc acg gct gtg     3120
 Leu Arg Tyr Thr Ser Glu Ser Gly Asp Arg Leu Asp Pro Thr Ala Val
1025                1030                1035                1040

 aac atc ctg cag cag atc att gag ctg ggc gcc gag acc cat gac gcc     3168
 Asn Ile Leu Gln Gln Ile Ile Glu Leu Gly Ala Glu Thr His Asp Ala
                1045                1050                1055

 act gcc ctt gcc tcg gtg gtt gcc atg gca cca ggg acg gtg act gtg     3216
 Thr Ala Leu Ala Ser Val Val Ala Met Ala Pro Gly Thr Val Thr Val
            1060                1065                1070

 gtt aag cag gtc acc gag gag gag ccc agc tcc aac cac acg gtc atg     3264
 Val Lys Gln Val Thr Glu Glu Glu Pro Ser Ser Asn His Thr Val Met
        1075                1080                1085

 atc cag gag acg gtc cag caa gcg tcc gtg gag ctt gcc gag cag cac     3312
 Ile Gln Glu Thr Val Gln Gln Ala Ser Val Glu Leu Ala Glu Gln His
    1090                1095                1100

 cac ctg gtg gtg tcc tcc gac gac gtg gag ggc att gag acg gtg act     3360
 His Leu Val Val Ser Ser Asp Asp Val Glu Gly Ile Glu Thr Val Thr
1105                1110                1115                1120

 gtc tac acg cag ggc ggg gag gcc tcg gag ttc atc gtc tac gtg cag     3408
 Val Tyr Thr Gln Gly Gly Glu Ala Ser Glu Phe Ile Val Tyr Val Gln
                1125                1130                1135

 gag gcc atg cag cct gtg gag gag cag gct gtg gag cag ccg gcc cag     3456
 Glu Ala Met Gln Pro Val Glu Glu Gln Ala Val Glu Gln Pro Ala Gln
            1140                1145                1150

 gaa ctc tag aggacat gtggcatcgg atggccacag ggcggggctg ccaggctctg     3512
 Glu Leu 


 caggcaccca gggtggggag gccacccttc ctgccctacc cgcagaatgg tgctctcctt   3572

 tgccctccct gcccagcagc ctgataggac tctcctagtc caacttgggg tgggcaaggc   3632

 agtcagcatc accagcaaca ccacaggacc ctcaccccag catagacaca caccccctga   3692

 cccttaccat ctgcttcctg aaagacttca gtgtcagctc ccctacacac accccacacc   3752

 ttcacccctt gcttcaagat tcaaacagag actcccagtc cccctcagca tcttccctga   3812

 atcacagccc cagctccttg acccccatct aggtgccaaa tgttcatctg caaccgctat   3872

 gcagtctggt gagagggaga cagccatcac atagaaagtg accgtacggg tttttaatca   3932

 ctgctgggtg gggtgggggt agggggattg tcctggcttt gtcgacaaag tcccacttcc   3992

 ccgagtatta agggcccttg gtatcaagtg aggtaaattc acccatcaca gggtctcgcc   4052

 ctaccatcct ggaattattt cacttttaag ataaatgcac tatttcactg ttcgcctccc   4112

 attctaagga ggtgaggtgg ttggaataaa aacagttcct gtcaaaaaaa aaaa         4166




      <210> 87
      <211> 6172
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(2777)

      <400> 87
 ctcgcgagga gagcggagca ggcgcgcggc ccaggcggag gagcgccgac tctggagcag     60

 ccggagctgg aagaggagga ggaggagagg cggcggggaa ggaggaggag ggggagagtc    120

 gctcccgccg ggcgagc   atg ggg cgc ctg gcc tcg agg ccg ctg ctg ctg     170
                      Met Gly Arg Leu Ala Ser Arg Pro Leu Leu Leu
                        1               5                  10

 gcg ctc ctg tcg ttg gct ctt tgc cga ggg cgt gtg gtg aga gtc ccc      218
 Ala Leu Leu Ser Leu Ala Leu Cys Arg Gly Arg Val Val Arg Val Pro
              15                  20                  25

 aca gcg acc ctg gtt cga gtg gtg ggc act gag ctg gtc atc ccc tgc      266
 Thr Ala Thr Leu Val Arg Val Val Gly Thr Glu Leu Val Ile Pro Cys
          30                  35                  40

 aac gtc agt gac tat gat ggc ccc agc gag caa aac ttt gac tgg agc      314
 Asn Val Ser Asp Tyr Asp Gly Pro Ser Glu Gln Asn Phe Asp Trp Ser
      45                  50                  55

 ttc tca tct ttg ggg agc agc ttt gtg gag ctt gca agc acc tgg gag      362
 Phe Ser Ser Leu Gly Ser Ser Phe Val Glu Leu Ala Ser Thr Trp Glu
  60                  65                  70                  75

 gtg ggg ttc cca gcc cag ctg tac cag gag cgg ctg cag agg ggc gag      410
 Val Gly Phe Pro Ala Gln Leu Tyr Gln Glu Arg Leu Gln Arg Gly Glu
                  80                  85                  90

 atc ctg tta agg cgg act gcc aac gac gcc gtg gag ctc cac ata aag      458
 Ile Leu Leu Arg Arg Thr Ala Asn Asp Ala Val Glu Leu His Ile Lys
              95                 100                 105

 aac gtc cag cct tca gac caa ggc cac tac aaa tgt tca acc ccc agc      506
 Asn Val Gln Pro Ser Asp Gln Gly His Tyr Lys Cys Ser Thr Pro Ser
         110                 115                 120

 aca gat gcc act gtc cag gga aac tat gag gac aca gtg cag gtt aaa      554
 Thr Asp Ala Thr Val Gln Gly Asn Tyr Glu Asp Thr Val Gln Val Lys
     125                 130                 135

 gtg ctg gcc gac tcc ctg cac gtg ggc ccc agc gcg cgg ccc ccg ccg      602
 Val Leu Ala Asp Ser Leu His Val Gly Pro Ser Ala Arg Pro Pro Pro
 140                 145                 150                 155

 agc ctg agc ctg cgg gag ggg gag ccc ttc gag ctg cgc tgc act gcc      650
 Ser Leu Ser Leu Arg Glu Gly Glu Pro Phe Glu Leu Arg Cys Thr Ala
                 160                 165                 170

 gcc tcc gcc tcg ccg ctg cac acg cac ctg gcg ctg ctg tgg gag gtg      698
 Ala Ser Ala Ser Pro Leu His Thr His Leu Ala Leu Leu Trp Glu Val
             175                 180                 185

 cac cgc ggc ccg gcc agg cgg agc gtc ctc gcc ctg acc cac gag ggc      746
 His Arg Gly Pro Ala Arg Arg Ser Val Leu Ala Leu Thr His Glu Gly
         190                 195                 200

 agg ttc cac ccg ggc ctg ggg tac gag cag cgc tac cac agt ggg gac      794
 Arg Phe His Pro Gly Leu Gly Tyr Glu Gln Arg Tyr His Ser Gly Asp
     205                 210                 215

 gtg cgc ctc gac acc gtg ggc agc gac gcc tac cgc ctc tca gtg tcc      842
 Val Arg Leu Asp Thr Val Gly Ser Asp Ala Tyr Arg Leu Ser Val Ser
 220                 225                 230                 235

 cgg gct ctg tct gcc gac cag ggc tcc tac agg tgt atc gtc agc gag      890
 Arg Ala Leu Ser Ala Asp Gln Gly Ser Tyr Arg Cys Ile Val Ser Glu
                 240                 245                 250

 tgg atc gcc gag cag ggc aac tgg cag gaa atc caa gaa aag gcc gtg      938
 Trp Ile Ala Glu Gln Gly Asn Trp Gln Glu Ile Gln Glu Lys Ala Val
             255                 260                 265

 gaa gtt gcc acc gtg gtg atc cag ccg aca gtt ctg cga gca gct gtg      986
 Glu Val Ala Thr Val Val Ile Gln Pro Thr Val Leu Arg Ala Ala Val
         270                 275                 280

 ccc aag aat gtg tct gtg gct gaa gga aag gaa ctg gac ctg acc tgt     1034
 Pro Lys Asn Val Ser Val Ala Glu Gly Lys Glu Leu Asp Leu Thr Cys
     285                 290                 295

 aac atc aca aca gac cga gcc gat gac gtc cgg ccc gag gtg acg tgg     1082
 Asn Ile Thr Thr Asp Arg Ala Asp Asp Val Arg Pro Glu Val Thr Trp
 300                 305                 310                 315

 tcc ttc agc agg atg cct gac agc acc cta cct ggc tcc cgc gtg ttg     1130
 Ser Phe Ser Arg Met Pro Asp Ser Thr Leu Pro Gly Ser Arg Val Leu
                 320                 325                 330

 gcg cgg ctt gac cgt gat tcc ctg gtg cac agc tcg cct cat gtt gct     1178
 Ala Arg Leu Asp Arg Asp Ser Leu Val His Ser Ser Pro His Val Ala
             335                 340                 345

 ttg agt cat gtg gat gca cgc tcc tac cat tta ctg gtt cgg gat gtt     1226
 Leu Ser His Val Asp Ala Arg Ser Tyr His Leu Leu Val Arg Asp Val
         350                 355                 360

 agc aaa gaa aac tct ggc tac tat tac tgc cac gtg tcc ctg tgg gca     1274
 Ser Lys Glu Asn Ser Gly Tyr Tyr Tyr Cys His Val Ser Leu Trp Ala
     365                 370                 375

 ccc gga cac aac agg agc tgg cac aaa gtg gca gag gcc gtg tct tcc     1322
 Pro Gly His Asn Arg Ser Trp His Lys Val Ala Glu Ala Val Ser Ser
 380                 385                 390                 395

 cca gct ggt gtg ggt gtg acc tgg cta gaa cca gac tac cag gtg tac     1370
 Pro Ala Gly Val Gly Val Thr Trp Leu Glu Pro Asp Tyr Gln Val Tyr
                 400                 405                 410

 ctg aat gct tcc aag gtc ccc ggg ttt gcg gat gac ccc aca gag ctg     1418
 Leu Asn Ala Ser Lys Val Pro Gly Phe Ala Asp Asp Pro Thr Glu Leu
             415                 420                 425

 gca tgc cag gtg gtg gac acg aag agt ggg gag gcg aat gtc cga ttc     1466
 Ala Cys Gln Val Val Asp Thr Lys Ser Gly Glu Ala Asn Val Arg Phe
         430                 435                 440

 acg gtt tcg tgg tac tac agg atg aac cgg cgc agc gac aat gtg gtg     1514
 Thr Val Ser Trp Tyr Tyr Arg Met Asn Arg Arg Ser Asp Asn Val Val
     445                 450                 455

 acc agc gag ctg ctt gca gtc atg gac ggg gac tgg acg cta aaa tat     1562
 Thr Ser Glu Leu Leu Ala Val Met Asp Gly Asp Trp Thr Leu Lys Tyr
 460                 465                 470                 475

 gga gag agg agc aag cag cgg gcc cag gat gga gac ttt att ttt tct     1610
 Gly Glu Arg Ser Lys Gln Arg Ala Gln Asp Gly Asp Phe Ile Phe Ser
                 480                 485                 490

 aag gaa cat aca gac acg ttc aat ttc cgg atc caa agg act aca gag     1658
 Lys Glu His Thr Asp Thr Phe Asn Phe Arg Ile Gln Arg Thr Thr Glu
             495                 500                 505

 gaa gac aga ggc aat tat tac tgt gtt gtg tct gcc tgg acc aaa cag     1706
 Glu Asp Arg Gly Asn Tyr Tyr Cys Val Val Ser Ala Trp Thr Lys Gln
         510                 515                 520

 cgg aac aac agc tgg gtg aaa agc aag gat gtc ttc tcc aag cct gtt     1754
 Arg Asn Asn Ser Trp Val Lys Ser Lys Asp Val Phe Ser Lys Pro Val
     525                 530                 535

 aac ata ttt tgg gca tta gaa gat tcc gtg ctt gtg gtg aag gcg agg     1802
 Asn Ile Phe Trp Ala Leu Glu Asp Ser Val Leu Val Val Lys Ala Arg
 540                 545                 550                 555

 cag cca aag cct ttc ttt gct gcc gga aat aca ttt gag atg act tgc     1850
 Gln Pro Lys Pro Phe Phe Ala Ala Gly Asn Thr Phe Glu Met Thr Cys
                 560                 565                 570

 aaa gta tct tcc aag aat att aag tcg cca cgc tac tct gtt ctc atc     1898
 Lys Val Ser Ser Lys Asn Ile Lys Ser Pro Arg Tyr Ser Val Leu Ile
             575                 580                 585

 atg gct gag aag cct gtc ggc gac ctc tcc agt ccc aat gaa acg aag     1946
 Met Ala Glu Lys Pro Val Gly Asp Leu Ser Ser Pro Asn Glu Thr Lys
         590                 595                 600

 tac atc atc tct ctg gac cag gat tct gtg gtg aag ctg gag aat tgg     1994
 Tyr Ile Ile Ser Leu Asp Gln Asp Ser Val Val Lys Leu Glu Asn Trp
     605                 610                 615

 aca gat gca tca cgg gtg gat ggc gtt gtt tta gaa aaa gtg cag gag     2042
 Thr Asp Ala Ser Arg Val Asp Gly Val Val Leu Glu Lys Val Gln Glu
 620                 625                 630                 635

 gat gag ttc cgc tat cga atg tac cag act cag gtc tca gac gca ggg     2090
 Asp Glu Phe Arg Tyr Arg Met Tyr Gln Thr Gln Val Ser Asp Ala Gly
                 640                 645                 650

 ctg tac cgc tgc atg gtg aca gcc tgg tct cct gtc agg ggc agc ctt     2138
 Leu Tyr Arg Cys Met Val Thr Ala Trp Ser Pro Val Arg Gly Ser Leu
             655                 660                 665

 tgg cga gaa gca gca acc agt ctc tcc aat cct att gag ata gac ttc     2186
 Trp Arg Glu Ala Ala Thr Ser Leu Ser Asn Pro Ile Glu Ile Asp Phe
         670                 675                 680

 caa acc tca ggt cct ata ttt aat gct tct gtg cat tca gac aca cca     2234
 Gln Thr Ser Gly Pro Ile Phe Asn Ala Ser Val His Ser Asp Thr Pro
     685                 690                 695

 tca gta att cgg gga gat ctg atc aaa ttg ttc tgt atc atc act gtc     2282
 Ser Val Ile Arg Gly Asp Leu Ile Lys Leu Phe Cys Ile Ile Thr Val
 700                 705                 710                 715

 gag gga gca gca ctg gat cca gat gac atg gcc ttt gat gtg tcc tgg     2330
 Glu Gly Ala Ala Leu Asp Pro Asp Asp Met Ala Phe Asp Val Ser Trp
                 720                 725                 730

 ttt gcg gtg cac tct ttt ggc ctg gac aag gct cct gtg ctc ctg tct     2378
 Phe Ala Val His Ser Phe Gly Leu Asp Lys Ala Pro Val Leu Leu Ser
             735                 740                 745

 tcc ctg gat cgg aag ggc atc gtg acc acc tcc cgg agg gac tgg aag     2426
 Ser Leu Asp Arg Lys Gly Ile Val Thr Thr Ser Arg Arg Asp Trp Lys
         750                 755                 760

 agc gac ctc agc ctg gag cgc gtg agt gtg ctg gaa ttc ttg ctg caa     2474
 Ser Asp Leu Ser Leu Glu Arg Val Ser Val Leu Glu Phe Leu Leu Gln
     765                 770                 775

 gtg cat ggc tcc gag gac cag gac ttt ggc aac tac tac tgt tcc gtg     2522
 Val His Gly Ser Glu Asp Gln Asp Phe Gly Asn Tyr Tyr Cys Ser Val
 780                 785                 790                 795

 act cca tgg gtg aag tca cca aca ggt tcc tgg cag aag gag gca gag     2570
 Thr Pro Trp Val Lys Ser Pro Thr Gly Ser Trp Gln Lys Glu Ala Glu
                 800                 805                 810

 atc cac tcc aag ccc gtt ttt ata act gtg aag atg gat gtg ctg aac     2618
 Ile His Ser Lys Pro Val Phe Ile Thr Val Lys Met Asp Val Leu Asn
             815                 820                 825

 gcc ttc aag tat ccc ttg ctg atc ggc atc ggt ctg tcc acg gtc atc     2666
 Ala Phe Lys Tyr Pro Leu Leu Ile Gly Ile Gly Leu Ser Thr Val Ile
         830                 835                 840

 ggg ctc ctg tcc tgt ctc atc ggg tac tgc agc tcc cac tgg tgt tgt     2714
 Gly Leu Leu Ser Cys Leu Ile Gly Tyr Cys Ser Ser His Trp Cys Cys
     845                 850                 855

 aag aag gag gtt cag gag aca cgg cgc gag cgc cgc agg ctc atg tcg     2762
 Lys Lys Glu Val Gln Glu Thr Arg Arg Glu Arg Arg Arg Leu Met Ser
 860                 865                 870                 875

 atg gag atg gac tag gctggcccgg gaggggagtg acagagggac gttctaggag     2817
 Met Glu Met Asp 


 caattggggc aagaagagga cagtgatatt ttaaaacaaa gtgtgttaca ctaaaaacca   2877

 gtcctctcta atctcaggtg ggacttggcg ctctctcttt tctgcatgtc aagttctgag   2937

 cgcggacatg tttaccagca cacggctctt cttcccacgg cactttctga tgtaacaatc   2997

 gagtgtgtgt tttcccaact gcagcttttt aatggttaac cttcatctaa ttttttttct   3057

 cccactggtt tatagatcct ctgacttgtg tgtgtttata gcttttgttt cgcggggttg   3117

 tggtgaggaa ggggtgatgg catgcggagt tctttatctt cagtgagaat gtgcctgccc   3177

 gcctgagagc cagcttccgc gttggaggca cgtgttcaga gagctgctga gcgccaccct   3237

 ctacccggct gacagacaac acagacctgt gccgaaggct aatttgtggc ttttacgacc   3297

 ctaccccacc ccctgttttc aggggtttag actacatttg aaatccaaac ttggagtata   3357

 taactttttt ttgagcccaa ctgctttttt tttttttttt tttgcttctc tgcccctttt   3417

 ccatttcttt tgtatttgtt ttctgtgaga gcactgaaat ggcagccctg gaatctacaa   3477

 tttggctctc cactgagcac cttatcttgc caccttagcc ttaagaatga atatgaagaa   3537

 aaatacacag ccacctctgt ccagggcagt aagaagggct gcaaggaagg ggaggatggg   3597

 gacaaggaaa ggatcagata cctgctccag tagttgtgag gccactgtgt ctcaggggac   3657

 tccaggagga gcagaagagg gatcccacga agttattctt acgcagctgg ggccaggagg   3717

 gtcagagtgg tgccaggtgc aagttaggct aaagaagcca ccactattcc tctctcttgc   3777

 ccattgtggg gggcaaaggc attggtcacc aagagtcttg cagggggacc cacagatatg   3837

 ccatgtcctt cacacgtgct tgggctcctt aacctgaagg caaattgcta cttgcaagac   3897

 tgactgactt caaggaatca gaaattacct agaagcacca tgttttttct atgacctttt   3957

 cagtccttca ggtcatttta aggtccactg cagggggtta gtgagaaagg gtatactttg   4017

 tggtatgttt tgctttccta atagggacat gaaggaaacc cagcaatttg ctgttatgtg   4077

 aatggcctgt agagcagagt caagagcggt gtgctttgcc cgactgctcc catcaggaat   4137

 aggagagtag acagagatct tccacatccc aggcttctgc tgctgcttta aaagctctgt   4197

 ccttggagcc tcccgctccc tgaagtgtct cgccccctgc acagcactgg cctttcggaa   4257

 gcatcccagt agggttttct gaggctcgct ggtgactcat gccctaattg caatcctctg   4317

 cttttatctt gactttgaag gatctaacac tgctctctct tccaaagggg aaaaaaagat   4377

 tcatttgttt tgagcaataa actaatacaa aatgatggcc attcatgtgc agctctttgt   4437

 caccatgggc cggatgagtt gtgctcctcc tggctcacca tttccccctg ctcccccaca   4497

 gccggttctg cacttatcac cgagtcgccc ctggaagcag attcccattg agttttcccc   4557

 accaagggga ccatgcacat ggtagaaaca ttagattctg cattgacagt agcctttcct   4617

 tggcccgggc ctgtggtggg aagacgggca acaagtatac cccaccaggg cctgagtgac   4677

 tagaggaaga ggacgaggcc ttgttggcac tagatttggg tattttctgc atgtcataac   4737

 atatcctaac tgctatttca gaagaggcag cttgtaggtg attgtacaag tgagaattaa   4797

 agagagaaca aatatttaaa caggtgctgt attagtaaca gccagtgccc tttcagccct   4857

 tgcatctatt aaaaggagat tcaggatttt attggcacag gcccttctta gtaggaagaa   4917

 agggtgctta gctttggacc tgaccgggtg tgtgtaaaac catggactga gtcacagcag   4977

 acactcgatg gtggtaaatg tgatgggtgc ttacacactg taccttttcc tttcatactg   5037

 atgctgcagt tcagggctgg agttgttaag gcattgacct ccacccacct gccccatgtc   5097

 cactgggctg cccaagctgc atgtcacctg agggctggca ggaaggggcg agaaatccca   5157

 gggcattgta ccaaggacct agttccttct agggatataa atttccagga atgtgtattt   5217

 ttaatgtggt gagatgcact cttttgttgt accaaatagg gctccccacc ccacccctgc   5277

 gacaagtgct cttctagaac aggttcctac cagcagcact ggtgtgaatg aaagagagac   5337

 ccagccgcgt ctcacacagg tggaattgca cttcttaaca aaaaggaact ttataaaagt   5397

 ttgggatttt ttttcctaat cataaaaata gccccagaaa gagcctaagc tatgttcaga   5457

 tagaagcctc gaaattcctg taaattgttt actttatgat gtttacatac acgtttcact   5517

 ttgaaaaaaa atgcaaatcg actttttaac aactgttgag atgtttcatg ggacagtaga   5577

 actctgactc accaactggg ctaaatttta atttaaaaat gtatttattt gagtgtcttt   5637

 ccccccctca ccctcaccat ctgaggggct ccctgagatc ttggtagagg aggcccctcc   5697

 tgcccagacc ttcgtttgtt tccccggtgg cccttgcttc ttgctttgca gactgcctgc   5757

 agccatgatt ttgtcactga catctgtgag ccaaagactg agcctttttg gcaggaataa   5817

 taagcaatac tacacaactt gctactttca gaaaactttt ttttagcttc accgatgaca   5877

 acagaggaag aagggaactg ggatttgggt aagttctcct ccactgtttg accaaattct   5937

 cagtgataaa tatgtgtgca gatccctaga agagaaaacg ctgactttct ttttaagtgt   5997

 ggcacataag gatctgcaga attttccgta gacaaagaaa ggatcttgtg tatttttgtc   6057

 catatccaat gttatatgaa ctaattgtat tgttttatac tgtgaccaca aatattatgc   6117

 aatgcaccat ttgtttttta tttcattaaa ggaagtttaa tttaaaaaaa aaaaa        6172




      <210> 88
      <211> 1192
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(669)

      <400> 88
  atg gaa gac caa aat gca ttg cac atc att gag acc atc aaa aga cat      48
  Met Glu Asp Gln Asn Ala Leu His Ile Ile Glu Thr Ile Lys Arg His
    1               5                  10                  15

 gtc tat gaa ttg ccc agg agc ccc caa agg ggt cct ccg cgg ccc cgc       96
 Val Tyr Glu Leu Pro Arg Ser Pro Gln Arg Gly Pro Pro Arg Pro Arg
              20                  25                  30

 ccc ttt acg tgc ggc ccc gcc cct tgg cgt ggc gcc ctg aca aat ggc      144
 Pro Phe Thr Cys Gly Pro Ala Pro Trp Arg Gly Ala Leu Thr Asn Gly
          35                  40                  45

 gcc gga agc ccc gcc ccc ggc cgg ttg cta ggc tcc gac agc cgg aag      192
 Ala Gly Ser Pro Ala Pro Gly Arg Leu Leu Gly Ser Asp Ser Arg Lys
      50                  55                  60

 tcc cgc ctg ccg tgt agt cgc cgc cgt cgc tgc cgc tgc cgc tgc cgc      240
 Ser Arg Leu Pro Cys Ser Arg Arg Arg Arg Cys Arg Cys Arg Cys Arg
  65                  70                  75                  80

 cgt cgt tgt tgt tgt gct cgg tgc gct gag ctc cgc ggc tcc gcg agc      288
 Arg Arg Cys Cys Cys Ala Arg Cys Ala Glu Leu Arg Gly Ser Ala Ser
                  85                  90                  95

 cgg ttc cgt ccc ctt ccc gcc gcc gcc atg aag tgg atg ttc aag gag      336
 Arg Phe Arg Pro Leu Pro Ala Ala Ala Met Lys Trp Met Phe Lys Glu
             100                 105                 110

 gac cac tcg ctg gaa cac aga tgc gtg gag tcc gcg aag att cga gcg      384
 Asp His Ser Leu Glu His Arg Cys Val Glu Ser Ala Lys Ile Arg Ala
         115                 120                 125

 aaa tat ccc gac agg gtt ccg gtg att gtg gaa aag gtc tca ggc tct      432
 Lys Tyr Pro Asp Arg Val Pro Val Ile Val Glu Lys Val Ser Gly Ser
     130                 135                 140

 cag att gtt gac att gac aaa cgg aag tac ttg gtt cca tct gat atc      480
 Gln Ile Val Asp Ile Asp Lys Arg Lys Tyr Leu Val Pro Ser Asp Ile
 145                 150                 155                 160

 act gtg gct cag ttc atg tgg atc atc agg aaa agg atc cag ctt cct      528
 Thr Val Ala Gln Phe Met Trp Ile Ile Arg Lys Arg Ile Gln Leu Pro
                 165                 170                 175

 tct gaa aag gcg atc ttc ctg ttt gtg gat aag aca gtc cca cag tcc      576
 Ser Glu Lys Ala Ile Phe Leu Phe Val Asp Lys Thr Val Pro Gln Ser
             180                 185                 190

 agc cta act atg gga cag ctt tac gag aag gaa aaa gat gaa gat gga      624
 Ser Leu Thr Met Gly Gln Leu Tyr Glu Lys Glu Lys Asp Glu Asp Gly
         195                 200                 205

 ttc tta tat gtg gcc tac agc gga gag aac act ttt ggc ttc tga ggg      672
 Phe Leu Tyr Val Ala Tyr Ser Gly Glu Asn Thr Phe Gly Phe 
     210                 215                 220

 ccattgctgg gctaggtgca ccgtaactgc ttgtgtatct tgtaaatagc cagccatttt    732

 cagttattat accagaacct cttcacatag acctattagt gcatttgtaa ctggatttat    792

 ttcttaatat attggaaggt tttgtttcct tagactagta aattatcata cagagtttta    852

 ttttgagttt ttctttttgt gcattgtcct catgcctgta ttctccagga aacttgtcct    912

 tctggaaatc atattgaatg atatttctat atcgaagtga ggtaggtgcg gtattaaagt    972

 gaaagggaag gtgatgcatt tattctgggt tatgcttgaa gtgttagatg gctaagtatt   1032

 aaaattatcc aaattaaatc cttagcagtc agaacacttg cttcactaga atatgccaac   1092

 tgccaatcat gttggactga gctaatttgt tcctctttct gaaactatta aggtaaataa   1152

 ttaacaataa aaattctctt ataaaggcaa aaaaaaaaaa                         1192




      <210> 89
      <211> 6224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3597)

      <400> 89
  atg gcc aca gct cat ctg cat gaa ata gat gca ggt gta att gag ttt      48
  Met Ala Thr Ala His Leu His Glu Ile Asp Ala Gly Val Ile Glu Phe
    1               5                  10                  15

 cct tgg aac aga gca ttg gct agc tgg ctg gct ggc acg ctt gct atg       96
 Pro Trp Asn Arg Ala Leu Ala Ser Trp Leu Ala Gly Thr Leu Ala Met
              20                  25                  30

 atg act cag atg caa agc atg ttg cta att tgt cct cct gtt act cgg      144
 Met Thr Gln Met Gln Ser Met Leu Leu Ile Cys Pro Pro Val Thr Arg
          35                  40                  45

 ttc ttc tat gga tgc aga gaa tat ttc cat aaa ctg tta att cag ggt      192
 Phe Phe Tyr Gly Cys Arg Glu Tyr Phe His Lys Leu Leu Ile Gln Gly
      50                  55                  60

 gat tct tct gga agg ttg aat att tgg aac ata tca gac aca gct gat      240
 Asp Ser Ser Gly Arg Leu Asn Ile Trp Asn Ile Ser Asp Thr Ala Asp
  65                  70                  75                  80

 aaa cag gga agt gaa gaa ggg ctg gca atg aca act tct att agt ttg      288
 Lys Gln Gly Ser Glu Glu Gly Leu Ala Met Thr Thr Ser Ile Ser Leu
                  85                  90                  95

 caa gag gca ttt gat aaa ctg aat cct tgt cct gct gga att ata gat      336
 Gln Glu Ala Phe Asp Lys Leu Asn Pro Cys Pro Ala Gly Ile Ile Asp
             100                 105                 110

 cag ctg agt gtg att ccc aat agt aat gaa cct ctt aaa gta act gca      384
 Gln Leu Ser Val Ile Pro Asn Ser Asn Glu Pro Leu Lys Val Thr Ala
         115                 120                 125

 agt gtg tac ata cca gca cat gga cga ctt gtt tgt ggt cgt gaa gat      432
 Ser Val Tyr Ile Pro Ala His Gly Arg Leu Val Cys Gly Arg Glu Asp
     130                 135                 140

 gga agc ata gtt att gta cct gcc aca cag acg gcc ata gta cag ctg      480
 Gly Ser Ile Val Ile Val Pro Ala Thr Gln Thr Ala Ile Val Gln Leu
 145                 150                 155                 160

 ttg caa ggg gaa cac atg ctc aga aga ggt tgg cca cct cac aga aca      528
 Leu Gln Gly Glu His Met Leu Arg Arg Gly Trp Pro Pro His Arg Thr
                 165                 170                 175

 ctc cgt ggt cat cgg aac aaa gtc aca tgt ttg cta tat cct cat cag      576
 Leu Arg Gly His Arg Asn Lys Val Thr Cys Leu Leu Tyr Pro His Gln
             180                 185                 190

 gtc tca gct cgg tat gat caa aga tac ctg ata tct gga ggt gtg gat      624
 Val Ser Ala Arg Tyr Asp Gln Arg Tyr Leu Ile Ser Gly Gly Val Asp
         195                 200                 205

 ttt tca gtc ata att tgg gac ata ttt tct gga gaa atg aaa cat atc      672
 Phe Ser Val Ile Ile Trp Asp Ile Phe Ser Gly Glu Met Lys His Ile
     210                 215                 220

 ttc tgt gtt cat ggt ggt gag att act caa ctt cta gtt cca cct gaa      720
 Phe Cys Val His Gly Gly Glu Ile Thr Gln Leu Leu Val Pro Pro Glu
 225                 230                 235                 240

 aac tgt agt gca aga gta cag cac tgc atc tgc tct gta gcc agt gac      768
 Asn Cys Ser Ala Arg Val Gln His Cys Ile Cys Ser Val Ala Ser Asp
                 245                 250                 255

 cac tca gta gga ctt cta agt ttg cga gag aaa aaa tgc ata atg ttg      816
 His Ser Val Gly Leu Leu Ser Leu Arg Glu Lys Lys Cys Ile Met Leu
             260                 265                 270

 gca tct cgt cac ctt ttt cct att caa gta atc aaa tgg agg cct tct      864
 Ala Ser Arg His Leu Phe Pro Ile Gln Val Ile Lys Trp Arg Pro Ser
         275                 280                 285

 gat gat tac ctg gtg gtg ggg tgt tca gat ggt tct gtg tac gtc tgg      912
 Asp Asp Tyr Leu Val Val Gly Cys Ser Asp Gly Ser Val Tyr Val Trp
     290                 295                 300

 caa atg gat act ggt gca ttg gat cgt tgt gtg atg ggg ata aca gca      960
 Gln Met Asp Thr Gly Ala Leu Asp Arg Cys Val Met Gly Ile Thr Ala
 305                 310                 315                 320

 gtt gag att cta aac gct tgt gat gaa gct gtt cct gct gct gtt gat     1008
 Val Glu Ile Leu Asn Ala Cys Asp Glu Ala Val Pro Ala Ala Val Asp
                 325                 330                 335

 tca ctt agt cat cca gca gtc aac cta aaa caa gct atg acg aga cgt     1056
 Ser Leu Ser His Pro Ala Val Asn Leu Lys Gln Ala Met Thr Arg Arg
             340                 345                 350

 agt ctt gct gct ctt aaa aat atg gcc cat cat aag cta caa acc ctt     1104
 Ser Leu Ala Ala Leu Lys Asn Met Ala His His Lys Leu Gln Thr Leu
         355                 360                 365

 gca act aac ctc ttg gct tct gag gca tct gac aag gga aat tta cct     1152
 Ala Thr Asn Leu Leu Ala Ser Glu Ala Ser Asp Lys Gly Asn Leu Pro
     370                 375                 380

 aaa tat tct cat aac tcc ctg atg gtt caa gca ata aag aca aac cta     1200
 Lys Tyr Ser His Asn Ser Leu Met Val Gln Ala Ile Lys Thr Asn Leu
 385                 390                 395                 400

 aca gac ccg gac ata cat gtg cta ttc ttt gat gtg gaa gcg ttg att     1248
 Thr Asp Pro Asp Ile His Val Leu Phe Phe Asp Val Glu Ala Leu Ile
                 405                 410                 415

 att caa ctc ctg act gaa gaa gcc tct agg ccg aat act gct ctt att     1296
 Ile Gln Leu Leu Thr Glu Glu Ala Ser Arg Pro Asn Thr Ala Leu Ile
             420                 425                 430

 tcc cca gag aat ttg caa aaa gca tct ggc agt tca gac aaa ggg ggc     1344
 Ser Pro Glu Asn Leu Gln Lys Ala Ser Gly Ser Ser Asp Lys Gly Gly
         435                 440                 445

 tct ttt tta act gga aaa cga gca gca gtt ctc ttc caa caa gtg aaa     1392
 Ser Phe Leu Thr Gly Lys Arg Ala Ala Val Leu Phe Gln Gln Val Lys
     450                 455                 460

 gaa acg atc aaa gag aac atc aag gaa cac ctc ctt gat gat gaa gag     1440
 Glu Thr Ile Lys Glu Asn Ile Lys Glu His Leu Leu Asp Asp Glu Glu
 465                 470                 475                 480

 gag gat gag gag ata atg agg cag aga agg gaa gaa agt gat cct gaa     1488
 Glu Asp Glu Glu Ile Met Arg Gln Arg Arg Glu Glu Ser Asp Pro Glu
                 485                 490                 495

 tat cgg tcc agc aaa tca aag cca ttg acc cta tta gaa tat aat tta     1536
 Tyr Arg Ser Ser Lys Ser Lys Pro Leu Thr Leu Leu Glu Tyr Asn Leu
             500                 505                 510

 act atg gac act gca aag ctg ttt atg tcc tgc ctt cac gcc tgg ggt     1584
 Thr Met Asp Thr Ala Lys Leu Phe Met Ser Cys Leu His Ala Trp Gly
         515                 520                 525

 ttg aat gaa gta ctg gat gaa gtt tgc ctg gat cgc ctt gga atg ctg     1632
 Leu Asn Glu Val Leu Asp Glu Val Cys Leu Asp Arg Leu Gly Met Leu
     530                 535                 540

 aaa ccc cac tgc acc gta tcg ttt ggc ctc ttg tca aga gga ggc cat     1680
 Lys Pro His Cys Thr Val Ser Phe Gly Leu Leu Ser Arg Gly Gly His
 545                 550                 555                 560

 atg tca ctg atg ctg ccg ggt tat aat cag cct gct tgt aaa ctg tca     1728
 Met Ser Leu Met Leu Pro Gly Tyr Asn Gln Pro Ala Cys Lys Leu Ser
                 565                 570                 575

 cat ggg aaa aca gaa gta gga agg aag ctg cca gcg tct gag gga gta     1776
 His Gly Lys Thr Glu Val Gly Arg Lys Leu Pro Ala Ser Glu Gly Val
             580                 585                 590

 gga aag gga act tac gga gtg tcc cgt gcc gtc acc aca cag cat ctc     1824
 Gly Lys Gly Thr Tyr Gly Val Ser Arg Ala Val Thr Thr Gln His Leu
         595                 600                 605

 ctg tct atc att tct ttg gca aat act tta atg agt atg acc aat gca     1872
 Leu Ser Ile Ile Ser Leu Ala Asn Thr Leu Met Ser Met Thr Asn Ala
     610                 615                 620

 act ttt att ggt gat cat atg aag aag ggt cct acc agg cca cct aga     1920
 Thr Phe Ile Gly Asp His Met Lys Lys Gly Pro Thr Arg Pro Pro Arg
 625                 630                 635                 640

 cca agc acc cca gac ctt tct aag gca agg ggt tcc cct cca act tcc     1968
 Pro Ser Thr Pro Asp Leu Ser Lys Ala Arg Gly Ser Pro Pro Thr Ser
                 645                 650                 655

 agt aat att gtg caa gga cag att aaa caa gtt gct gca cct gtc gtt     2016
 Ser Asn Ile Val Gln Gly Gln Ile Lys Gln Val Ala Ala Pro Val Val
             660                 665                 670

 tcc gct cgg tct gat gct gat cac tct ggc tct gac cct cct tct gct     2064
 Ser Ala Arg Ser Asp Ala Asp His Ser Gly Ser Asp Pro Pro Ser Ala
         675                 680                 685

 cct gct tta cat acc tgt ttc tta gta aat gaa ggt tgg agt cag tta     2112
 Pro Ala Leu His Thr Cys Phe Leu Val Asn Glu Gly Trp Ser Gln Leu
     690                 695                 700

 gct gct atg cac tgt gtt atg ctg cca gac cta ctg gga ttg gat aaa     2160
 Ala Ala Met His Cys Val Met Leu Pro Asp Leu Leu Gly Leu Asp Lys
 705                 710                 715                 720

 ttt agg cct ccc ctt ctg gag atg ctg gcc cga aga tgg caa gat cga     2208
 Phe Arg Pro Pro Leu Leu Glu Met Leu Ala Arg Arg Trp Gln Asp Arg
                 725                 730                 735

 tgc ttg gag gtg aga gaa gcc gca cag gcc ctg ctt ctg gcg gaa ctg     2256
 Cys Leu Glu Val Arg Glu Ala Ala Gln Ala Leu Leu Leu Ala Glu Leu
             740                 745                 750

 aga aga att gag cag gca ggc agg aag gaa gcc att gat gcc tgg gct     2304
 Arg Arg Ile Glu Gln Ala Gly Arg Lys Glu Ala Ile Asp Ala Trp Ala
         755                 760                 765

 cct tac tta cct cag tac ata gac cac gtc ata tca cct gga gtc aca     2352
 Pro Tyr Leu Pro Gln Tyr Ile Asp His Val Ile Ser Pro Gly Val Thr
     770                 775                 780

 tca gaa gcc gcg cag act atc acc acg gct cct gat gcc tca ggg cct     2400
 Ser Glu Ala Ala Gln Thr Ile Thr Thr Ala Pro Asp Ala Ser Gly Pro
 785                 790                 795                 800

 gaa gca aaa gtc cag gag gaa gag cat gac ctt gtt gac gat gac atc     2448
 Glu Ala Lys Val Gln Glu Glu Glu His Asp Leu Val Asp Asp Asp Ile
                 805                 810                 815

 acc act ggt tgc tta tca agt gtc cca caa atg aaa aaa att tct aca     2496
 Thr Thr Gly Cys Leu Ser Ser Val Pro Gln Met Lys Lys Ile Ser Thr
             820                 825                 830

 tct tac gag gaa aga cgg aag caa gct acc gct att gtt tta ctt gga     2544
 Ser Tyr Glu Glu Arg Arg Lys Gln Ala Thr Ala Ile Val Leu Leu Gly
         835                 840                 845

 gta ata gga gct gaa ttt ggt gct gaa att gaa cct cct aaa cta ttg     2592
 Val Ile Gly Ala Glu Phe Gly Ala Glu Ile Glu Pro Pro Lys Leu Leu
     850                 855                 860

 acc aga cct cga agc tct agc caa att cct gag gga ttc ggg ttg act     2640
 Thr Arg Pro Arg Ser Ser Ser Gln Ile Pro Glu Gly Phe Gly Leu Thr
 865                 870                 875                 880

 agt ggt gga tcc aac tac tcg ctg gcc aga cat act tgc aag gca ctg     2688
 Ser Gly Gly Ser Asn Tyr Ser Leu Ala Arg His Thr Cys Lys Ala Leu
                 885                 890                 895

 acg ttt ctt ctg cta cag cct cca agc ccc aaa ctt cct cca cac agc     2736
 Thr Phe Leu Leu Leu Gln Pro Pro Ser Pro Lys Leu Pro Pro His Ser
             900                 905                 910

 act atc cga aga aca gcc att gat ctg att gga cgt ggg ttc act gtt     2784
 Thr Ile Arg Arg Thr Ala Ile Asp Leu Ile Gly Arg Gly Phe Thr Val
         915                 920                 925

 tgg gag cct tac atg gat gtg tcc gct gtt ctg atg ggg ctt ctc gaa     2832
 Trp Glu Pro Tyr Met Asp Val Ser Ala Val Leu Met Gly Leu Leu Glu
     930                 935                 940

 ctt tgt gcc gat gcc gag aaa caa ctt gcc aac atc aca atg ggg ttg     2880
 Leu Cys Ala Asp Ala Glu Lys Gln Leu Ala Asn Ile Thr Met Gly Leu
 945                 950                 955                 960

 cct ctg agc cca gca gct gac tcg gcc cgc tct gcg agg cat gcc ctc     2928
 Pro Leu Ser Pro Ala Ala Asp Ser Ala Arg Ser Ala Arg His Ala Leu
                 965                 970                 975

 tcg ctc att gcc acc gcc aga cca ccc gcc ttc atc acc acc ata gcc     2976
 Ser Leu Ile Ala Thr Ala Arg Pro Pro Ala Phe Ile Thr Thr Ile Ala
             980                 985                 990

 aaa gag gta cac aga cat acg gct ctt gca gca aat acc caa tca cag     3024
 Lys Glu Val His Arg His Thr Ala Leu Ala Ala Asn Thr Gln Ser Gln
         995                1000                1005

 cag aat atg cac aca aca act ctt gca cga gct aaa ggg gaa att ttg     3072
 Gln Asn Met His Thr Thr Thr Leu Ala Arg Ala Lys Gly Glu Ile Leu
    1010                1015                1020

 aga gtc att gaa att ctt att gaa aag atg ccc aca gat gtt gtg gat     3120
 Arg Val Ile Glu Ile Leu Ile Glu Lys Met Pro Thr Asp Val Val Asp
1025                1030                1035                1040

 ctt ctc gtg gag gtt atg gac atc att atg tac tgc ctt gaa gga tct     3168
 Leu Leu Val Glu Val Met Asp Ile Ile Met Tyr Cys Leu Glu Gly Ser
                1045                1050                1055

 tta gtt aaa aag aaa ggt ctt caa gaa tgt ttc cca gcc atc tgc agg     3216
 Leu Val Lys Lys Lys Gly Leu Gln Glu Cys Phe Pro Ala Ile Cys Arg
            1060                1065                1070

 ttc tac atg gtc agc tat tat gag cgg aat cac aga ata gca gtt gga     3264
 Phe Tyr Met Val Ser Tyr Tyr Glu Arg Asn His Arg Ile Ala Val Gly
        1075                1080                1085

 gct cgc cat ggt tca gtg gcc ctg tac gac atc cgg act gga aaa tgt     3312
 Ala Arg His Gly Ser Val Ala Leu Tyr Asp Ile Arg Thr Gly Lys Cys
    1090                1095                1100

 cag aca atc cat gga cac aag gga cca atc act gca gtg gct ttt gct     3360
 Gln Thr Ile His Gly His Lys Gly Pro Ile Thr Ala Val Ala Phe Ala
1105                1110                1115                1120

 cct gat gga aga tat ctt gcc acc tac tca aac act gac agc cac att     3408
 Pro Asp Gly Arg Tyr Leu Ala Thr Tyr Ser Asn Thr Asp Ser His Ile
                1125                1130                1135

 tct ttt tgg cag atg aac acg tca ctg ctg gga agc atc ggc atg ctg     3456
 Ser Phe Trp Gln Met Asn Thr Ser Leu Leu Gly Ser Ile Gly Met Leu
            1140                1145                1150

 aac tcg gca cct cag ctg cgc tgc att aaa acc tac cag gtg ccc cct     3504
 Asn Ser Ala Pro Gln Leu Arg Cys Ile Lys Thr Tyr Gln Val Pro Pro
        1155                1160                1165

 gtg cag ccc gcg tcc ccc ggc tcc cac aat gcc ctc aag ctg ggc ccg     3552
 Val Gln Pro Ala Ser Pro Gly Ser His Asn Ala Leu Lys Leu Gly Pro
    1170                1175                1180

 gct cat ctg gac ttc caa ccg caa cgt cat cct cat ggc cca tga cgg     3600
 Ala His Leu Asp Phe Gln Pro Gln Arg His Pro His Gly Pro 
1185                1190                1195

 gaaggagcac cgcttcatgg tctaatgctg ctgcctgccg ccgtgactgc gttttagttc   3660

 tctaaattat ccaagccgat gttgctctgt ccttcctcac accagattgt tcccaggggc   3720

 ctgcccaccc cagtgccatc cagtggcacg gccggccggg tcttgtcact tgtgcatgct   3780

 tctcaggggc agaacccgct cgtgccatct gtcgattcag aggcacgcac acatgctctg   3840

 caggatgtgg ccatcctgtc accaggtagt ttttccctgc cagagatggc aggggaaagc   3900

 cagcggttcc tgggaacgct cttgttgctt ggtgcaacag aagcacaaaa atcaataaac   3960

 actgtgattg cactcccagc ccagatcagc atttttagcc atctcaaccg cacctctgaa   4020

 gtgctgcttg aatctggccg ttctgacact gggtgttgag gtcatgtggc agtcctcacg   4080

 attgaaatta ttgccctttg aattacctaa aatattgttt accaaaaaga ttctgtgttt   4140

 acatgttctt ttcttctggt gattgctagg aaattactca atccaatttc ctagggttta   4200

 gctaccacct tctttatcaa cagctaacca atttgagatt catgattaat tatgtacaca   4260

 aaaatatttt ccttgtagaa aatagttttc cagacactta gccttctgaa gtgctcatct   4320

 cttgcttaaa tgatagtcta tttagtagtt taaaataaaa ataatcactc cctatgatct   4380

 agttaatgta attatccagt cactgtaact aatctcttga agggactttt gtgataaaga   4440

 gccaagttca gaagcatagc gtgtaccgaa aatgaagact ctcctatcta ctgctacaga   4500

 tcctgttgaa gaaagagctt acccctttcc cccggaaaac ttgcaatcct gtagttccca   4560

 tatgtgtggc atatgtcagt tatgaaatta ttataattca gccttcaaac tactactgat   4620

 caactaaagg aaagctaata aggtatttct tttaaacaag tattctggaa aagtaataac   4680

 tatggcacaa atgttcagga gtgtatataa aaatatgtgg gctctcgatt tatttgagca   4740

 aacattgcaa tgagggtgtt cattatgctt ctaagtaagc tttaactaga ccactttctt   4800

 cttatgtcag attgtgctgg ttctagctca taataatgaa aaaaatagaa ttatattttg   4860

 tatgaattgt ttctaacaaa ccttgatctg tatatacttg tgaggggttg tttggttgcc   4920

 taattgttga ttggttggtt agttgggcaa aatcatttat tacatgcaaa aatagaaaat   4980

 tatttgttaa attcagagaa aatatgtgaa gtttacaaag gaaccaaaat gataatggga   5040

 gaatttagtc ttaaaagttt aggttgtcag agtttatctg atatacaaaa aagtaggatc   5100

 aaagtctagg aacaaacatt ggttatttca ctgaaacaga tttttaaaga gcatattaag   5160

 aaattaagac cattagatca tctctttcat aatgatatga tgttatttcc attgacggca   5220

 aatctatact gttccttggt tttagagttg ggtattcttt caaaagtgaa tttaggcaca   5280

 tgcatgtaca ttgtatttat aaagattata tatgtagttt ccaaggaaga aacaaagacc   5340

 tatacagttt agactttatt tgtttggtga acgtgctgtt gtgtttggca tagctagaga   5400

 aatgtaaggt aaaaggctca ctttgttttc cagtgggtcc agagtcttct ctatacccaa   5460

 catatgttta ctttatgaac ttaaatggaa attaatttat tgtagactac atctctattt   5520

 ggaatgatga ggtaaatgta taccttagca ttttctttaa caaaaatgtt ctgtgtgtca   5580

 ggaaagaggt gtgagagcgg taggcagcct gccgcaaaca cacggatggc tcccaccgcc   5640

 acgaaggttg agaacaaagc cagggggccc agaggagcaa tagccctggg ccacaagcgt   5700

 gggtaggcct ttcacgtatt ccgtctgcac aggcaaccaa ggccagtaga aagctatggc   5760

 tgcaaaaccc tggggtggac gatgtttgat gattagacgg tcatctctaa ctactaaact   5820

 aatatctgca ttcttgttaa cataaatctc tccttggcta ttttaatagc cacagtccca   5880

 aacttcatcc cagcttagat ttctcagcac tgaggtaaac tctgcattgt catcccagcg   5940

 tacaccttta atgttttatt gatttcactg gcactgtatt tggacctgtc cttgtatatg   6000

 tagagacata tgtggcttca ttggtaattt acaagcaaaa gatgacatga cgtgacacct   6060

 gtatgaaaat gtgatgattg aactccctgt gtacagcgag tgaattaaaa tgtctgcctc   6120

 tccagacatt tcttaatgat tccacttaat agactctatg tgtgctgaat gttcctgtgt   6180

 acatatgtgt gttaaataaa acaattgtat tgaaaaaaaa aaaa                    6224




      <210> 90
      <211> 650
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(603)

      <400> 90
 gcacgaggtc gcgggggcgg gctcgggaaa gaccgtgcca gcggcgtgtg gcgcgggttt     60

 cgcacggtcc aataagggag ggcggcgtgg ccggcc  atg gta gcg acg agg acg     114
                                          Met Val Ala Thr Arg Thr
                                            1               5

 cgc ctg cgc aga ggc ggc agc acc acc ggg gtt gac tcc ggg ggc gcg      162
 Arg Leu Arg Arg Gly Gly Ser Thr Thr Gly Val Asp Ser Gly Gly Ala
              10                  15                  20

 gcg agg aga gac atg agg ctg agc tgg ttc cgg gtc ctg aca gta ctg      210
 Ala Arg Arg Asp Met Arg Leu Ser Trp Phe Arg Val Leu Thr Val Leu
          25                  30                  35

 tcc atc tgc ctg agc gcc gtg gcc acg gcc acg ggg gcc gag ggc aaa      258
 Ser Ile Cys Leu Ser Ala Val Ala Thr Ala Thr Gly Ala Glu Gly Lys
      40                  45                  50

 agg aag ctg cag atc ggg gtc aag aag cgg gtg gac cac tgt ccc atc      306
 Arg Lys Leu Gln Ile Gly Val Lys Lys Arg Val Asp His Cys Pro Ile
  55                  60                  65                  70

 aaa tcg cgc aaa ggg gat gtc ctg cac atg cac tac acg ggg aag ctg      354
 Lys Ser Arg Lys Gly Asp Val Leu His Met His Tyr Thr Gly Lys Leu
                  75                  80                  85

 gaa gat ggg aca gag ttt gac agc agc ctg ccc cag aac cag ccc ttt      402
 Glu Asp Gly Thr Glu Phe Asp Ser Ser Leu Pro Gln Asn Gln Pro Phe
              90                  95                 100

 gtc ttc tcc ctt ggc aca ggc cag gtc atc aag ggc tgg gac cag ggg      450
 Val Phe Ser Leu Gly Thr Gly Gln Val Ile Lys Gly Trp Asp Gln Gly
         105                 110                 115

 ctg ctg ggg atg tgt gag ggg gaa aag cgc aag ctg gtg atc cca tcc      498
 Leu Leu Gly Met Cys Glu Gly Glu Lys Arg Lys Leu Val Ile Pro Ser
     120                 125                 130

 gag cta ggg tat gga gag cgg gga gct ccc cca aag att cca ggc ggt      546
 Glu Leu Gly Tyr Gly Glu Arg Gly Ala Pro Pro Lys Ile Pro Gly Gly
 135                 140                 145                 150

 gca acc ctg gtg ttc gag gtg gag ctg ctc aaa ata gag cga cga act      594
 Ala Thr Leu Val Phe Glu Val Glu Leu Leu Lys Ile Glu Arg Arg Thr
                 155                 160                 165

 gag ctg taa ccagact ggggaggggc agggggagag gcccccatca gggaccagac      650
 Glu Leu 






      <210> 91
      <211> 2094
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (490)..(2052)

      <400> 91
 aaaataacta cagcaaggtg ttctttagca aaagtttgac aaccacagac ttaagcattt     60

 aatacagatg catgagtcat gagtgcaagc ttttacatac ttgttacaac tttatttcct    120

 tagtatttca ttttcctaac ttgtatctgt gtgctagtgt ttgtttaggc attagtgtaa    180

 tgtatttata taaacattct tttttaagct gaagcatttg atttgattgc acaagatgaa    240

 gaagaattta ataaagagca tcaatttata caggaagaaa acatagatgc tcataatact    300

 tcggttgcac tgggcgatac gtcctgggga gctacaatta attacagtct gttgaggaaa    360

 tcacgtagca catcagattt ggataaagat gatgccagtt atttacgtct gtctttagga    420

 gagttctttg ctcaaagatc tgaagctctt ggttgccttg gtggtggtaa caatgtgaaa    480

 agagtaagt    atg gaa tct gtt gga agt gct cac agt cac cag att tta     528
              Met Glu Ser Val Gly Ser Ala His Ser His Gln Ile Leu
                1               5                  10

 gat ttt gag tat tat gat ggc aca cca tca ttt ggc tat ttt att aga      576
 Asp Phe Glu Tyr Tyr Asp Gly Thr Pro Ser Phe Gly Tyr Phe Ile Arg
      15                  20                  25

 tca cca gag aag aga gaa cct att gcc tta ata aga aaa tct gat gta      624
 Ser Pro Glu Lys Arg Glu Pro Ile Ala Leu Ile Arg Lys Ser Asp Val
  30                  35                  40                  45

 tca aga ggt aat ttg gaa aaa gaa atg gct cat ctt aac cat gat cta      672
 Ser Arg Gly Asn Leu Glu Lys Glu Met Ala His Leu Asn His Asp Leu
                  50                  55                  60

 tat tca gga gat tta aat gaa cag tcc cag gca cag cta agt gaa gga      720
 Tyr Ser Gly Asp Leu Asn Glu Gln Ser Gln Ala Gln Leu Ser Glu Gly
              65                  70                  75

 tca att aca ctt cag gtt gaa gca gta gag agt act tca caa gtg gat      768
 Ser Ile Thr Leu Gln Val Glu Ala Val Glu Ser Thr Ser Gln Val Asp
          80                  85                  90

 gaa aat gat gtg acg tta acg gct gat aaa ggc aaa aca gag gac act      816
 Glu Asn Asp Val Thr Leu Thr Ala Asp Lys Gly Lys Thr Glu Asp Thr
      95                 100                 105

 ttc ttc atg agc aac aaa ccc caa aga tac aaa gac aag cta cca gat      864
 Phe Phe Met Ser Asn Lys Pro Gln Arg Tyr Lys Asp Lys Leu Pro Asp
 110                 115                 120                 125

 agt ggt gat tct atg ctt agg atc agc acc att gct tca gcc att gca      912
 Ser Gly Asp Ser Met Leu Arg Ile Ser Thr Ile Ala Ser Ala Ile Ala
                 130                 135                 140

 gag gca tca gtt aat act gat cct tcc caa ctt gct gca atg atc aag      960
 Glu Ala Ser Val Asn Thr Asp Pro Ser Gln Leu Ala Ala Met Ile Lys
             145                 150                 155

 gca ctt tca aat aaa acc aga gac aag act ttt cag gaa gat gag aaa     1008
 Ala Leu Ser Asn Lys Thr Arg Asp Lys Thr Phe Gln Glu Asp Glu Lys
         160                 165                 170

 caa aag gac tat tct cat gtg cgt cat ttc tta cct aat gat tta gaa     1056
 Gln Lys Asp Tyr Ser His Val Arg His Phe Leu Pro Asn Asp Leu Glu
     175                 180                 185

 aaa agt aat gga tcc aat gca ctt gat atg gag aaa tac ctt aaa aaa     1104
 Lys Ser Asn Gly Ser Asn Ala Leu Asp Met Glu Lys Tyr Leu Lys Lys
 190                 195                 200                 205

 aca gaa gtt agt aga tat gaa agt gca ttg gaa aac ttt tca agg gct     1152
 Thr Glu Val Ser Arg Tyr Glu Ser Ala Leu Glu Asn Phe Ser Arg Ala
                 210                 215                 220

 agt atg tct gat act tgg gat tta tct ttg ccc aaa gaa caa act act     1200
 Ser Met Ser Asp Thr Trp Asp Leu Ser Leu Pro Lys Glu Gln Thr Thr
             225                 230                 235

 caa gac att cat ccg gtg gac tta agt gct act agt gta agt gtg agg     1248
 Gln Asp Ile His Pro Val Asp Leu Ser Ala Thr Ser Val Ser Val Arg
         240                 245                 250

 gca cca gaa gaa aac aca gca gct att gtt tat gtt gaa aat gga gag     1296
 Ala Pro Glu Glu Asn Thr Ala Ala Ile Val Tyr Val Glu Asn Gly Glu
     255                 260                 265

 agt gag aat caa gag tca ttt aga acc ata aac tcc tca aat tca gtt     1344
 Ser Glu Asn Gln Glu Ser Phe Arg Thr Ile Asn Ser Ser Asn Ser Val
 270                 275                 280                 285

 aca aat aga gag aat aac agt gca gta gtt gat gtg aag aca tgt tcc     1392
 Thr Asn Arg Glu Asn Asn Ser Ala Val Val Asp Val Lys Thr Cys Ser
                 290                 295                 300

 att gac aac aaa tta caa gat gtt ggt aac gat gaa aaa gct acc tca     1440
 Ile Asp Asn Lys Leu Gln Asp Val Gly Asn Asp Glu Lys Ala Thr Ser
             305                 310                 315

 att tcc act cca tct gat agt tat tca tca gtg agg aac ccc aga ata     1488
 Ile Ser Thr Pro Ser Asp Ser Tyr Ser Ser Val Arg Asn Pro Arg Ile
         320                 325                 330

 aca tcc ctt tgt ctg tta aaa gac tgt gaa gaa ata cga gat aac aga     1536
 Thr Ser Leu Cys Leu Leu Lys Asp Cys Glu Glu Ile Arg Asp Asn Arg
     335                 340                 345

 gaa aat cag agg caa aat gag tgt gtc agt gaa ata agc aac agt gag     1584
 Glu Asn Gln Arg Gln Asn Glu Cys Val Ser Glu Ile Ser Asn Ser Glu
 350                 355                 360                 365

 aag cat gtg act ttt gaa aac cat cgc ata gtc tca cct aaa aat agt     1632
 Lys His Val Thr Phe Glu Asn His Arg Ile Val Ser Pro Lys Asn Ser
                 370                 375                 380

 gat ttg aaa aat acc tct cct gag cat ggt gga cgt ggc tca gag gat     1680
 Asp Leu Lys Asn Thr Ser Pro Glu His Gly Gly Arg Gly Ser Glu Asp
             385                 390                 395

 gag cag gag agc ttc aga cct tcc acg tca cca ctg agt cat tct tct     1728
 Glu Gln Glu Ser Phe Arg Pro Ser Thr Ser Pro Leu Ser His Ser Ser
         400                 405                 410

 cct agt gaa att tct gga acg agt tca tca ggg tgt gcg tta gag tcc     1776
 Pro Ser Glu Ile Ser Gly Thr Ser Ser Ser Gly Cys Ala Leu Glu Ser
     415                 420                 425

 ttt ggt tca gca gct cag cag cag cag cct ccc tgt gag cag gag ttg     1824
 Phe Gly Ser Ala Ala Gln Gln Gln Gln Pro Pro Cys Glu Gln Glu Leu
 430                 435                 440                 445

 tct ccc ttg gtg tgc tcg cct gct ggg gtg agc agg ctg acg tat gtg     1872
 Ser Pro Leu Val Cys Ser Pro Ala Gly Val Ser Arg Leu Thr Tyr Val
                 450                 455                 460

 tct gaa cca gag agc tcc tat cct acc aca gcc aca gat gat gcc ctg     1920
 Ser Glu Pro Glu Ser Ser Tyr Pro Thr Thr Ala Thr Asp Asp Ala Leu
             465                 470                 475

 gag gac cgc aag gtg ggc agc cac ttg gat tat tta tta cta agg ctt     1968
 Glu Asp Arg Lys Val Gly Ser His Leu Asp Tyr Leu Leu Leu Arg Leu
         480                 485                 490

 tca act ctt aaa agt gtt aac aga tgt ttg att cag act aca gtt caa     2016
 Ser Thr Leu Lys Ser Val Asn Arg Cys Leu Ile Gln Thr Thr Val Gln
     495                 500                 505

 gcc tat ata act tca gtg ttg ctc ttt tat ctt taa aatg atttttgtat     2066
 Ala Tyr Ile Thr Ser Val Leu Leu Phe Tyr Leu 
 510                 515                 520

 ttgtgtgcac atattaaata cctactca                                      2094




      <210> 92
      <211> 2662
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (52)..(1950)

      <400> 92
 agtagtgata aatttaaaga gacttcagaa gttttagaac ggaaaatatc t atg cga      57
                                                          Met Arg
                                                            1

 aag cca aga gaa gag ctg gtt aaa aga ggg gtt ctg ttg gaa gac cct      105
 Lys Pro Arg Glu Glu Leu Val Lys Arg Gly Val Leu Leu Glu Asp Pro
           5                  10                  15

 gag caa ggt ggt gag gat cca gga aag cca agc gat gcc atg tta aag      153
 Glu Gln Gly Gly Glu Asp Pro Gly Lys Pro Ser Asp Ala Met Leu Lys
      20                  25                  30

 aat ggc cat acc acc ccc ata ggg aat gcc aga tca tct agt cca gtc      201
 Asn Gly His Thr Thr Pro Ile Gly Asn Ala Arg Ser Ser Ser Pro Val
  35                  40                  45                  50

 caa gta gag gaa gag cca gta aga tta gca agt ctt agg aaa gct att      249
 Gln Val Glu Glu Glu Pro Val Arg Leu Ala Ser Leu Arg Lys Ala Ile
                  55                  60                  65

 cca gaa gag gac cta aag aaa cga cta ggc tca act gga agc cag cct      297
 Pro Glu Glu Asp Leu Lys Lys Arg Leu Gly Ser Thr Gly Ser Gln Pro
              70                  75                  80

 aat tct gaa gca gag tct gtt cct gag aat gta ccc aaa cca cct tta      345
 Asn Ser Glu Ala Glu Ser Val Pro Glu Asn Val Pro Lys Pro Pro Leu
          85                  90                  95

 ctt cct ccc aaa aga ccc ttg tcc tct tct cat gaa gca agt gaa ggg      393
 Leu Pro Pro Lys Arg Pro Leu Ser Ser Ser His Glu Ala Ser Glu Gly
     100                 105                 110

 caa gca aag gat gcc act tcc tct ggc ggc acg gca agg ttc atc atc      441
 Gln Ala Lys Asp Ala Thr Ser Ser Gly Gly Thr Ala Arg Phe Ile Ile
 115                 120                 125                 130

 tcc acc tcc atc acc aca gca ccc gct gcc acc act gct gcc aca agc      489
 Ser Thr Ser Ile Thr Thr Ala Pro Ala Ala Thr Thr Ala Ala Thr Ser
                 135                 140                 145

 ctt gca aag act gtt aat ctc tct gtc acc cct tcc cca gca ccc agg      537
 Leu Ala Lys Thr Val Asn Leu Ser Val Thr Pro Ser Pro Ala Pro Arg
             150                 155                 160

 act ctg cct gct gct cct gcc agc act aac act act gct acc cca agc      585
 Thr Leu Pro Ala Ala Pro Ala Ser Thr Asn Thr Thr Ala Thr Pro Ser
         165                 170                 175

 ctc act cat atg gtc cct gcc aag cag ccc cct atc cct ccc cct aaa      633
 Leu Thr His Met Val Pro Ala Lys Gln Pro Pro Ile Pro Pro Pro Lys
     180                 185                 190

 cca gct cac aga aat agc aac cct gtc att gct gaa ctg tcc caa gca      681
 Pro Ala His Arg Asn Ser Asn Pro Val Ile Ala Glu Leu Ser Gln Ala
 195                 200                 205                 210

 ata aac agt ggt aca ttg tta tca aaa ccg tcc cca ccc tta cca cct      729
 Ile Asn Ser Gly Thr Leu Leu Ser Lys Pro Ser Pro Pro Leu Pro Pro
                 215                 220                 225

 aag aga ggc att cca tca acc tca gta ccc acc ttg gag tct gct gct      777
 Lys Arg Gly Ile Pro Ser Thr Ser Val Pro Thr Leu Glu Ser Ala Ala
             230                 235                 240

 gcc atc acc aca aaa aca cca agt gat gaa aga gag aag agc acg tgt      825
 Ala Ile Thr Thr Lys Thr Pro Ser Asp Glu Arg Glu Lys Ser Thr Cys
         245                 250                 255

 tct atg ggc tcg gaa cta cta cca atg atc tca cct cgc tct ccg tcc      873
 Ser Met Gly Ser Glu Leu Leu Pro Met Ile Ser Pro Arg Ser Pro Ser
     260                 265                 270

 ccc cca ctg cct act cat ata cct cca gag cct cca cgc acc cct cca      921
 Pro Pro Leu Pro Thr His Ile Pro Pro Glu Pro Pro Arg Thr Pro Pro
 275                 280                 285                 290

 ttc cct gct aag act ttt caa gtt gtg cca gaa att gag ttt cca cca      969
 Phe Pro Ala Lys Thr Phe Gln Val Val Pro Glu Ile Glu Phe Pro Pro
                 295                 300                 305

 tcc tta gat cta cac cag gag att ccc cag cag gaa gat cag aaa aag     1017
 Ser Leu Asp Leu His Gln Glu Ile Pro Gln Gln Glu Asp Gln Lys Lys
             310                 315                 320

 gaa gtc ccc aag agg ata ctg gac cag aac ttt ggg gag ccc cat ata     1065
 Glu Val Pro Lys Arg Ile Leu Asp Gln Asn Phe Gly Glu Pro His Ile
         325                 330                 335

 ccc tct agg ctg cct cca ctc cca ctg cat att cga atc cag cag gcc     1113
 Pro Ser Arg Leu Pro Pro Leu Pro Leu His Ile Arg Ile Gln Gln Ala
     340                 345                 350

 ctc acc agc cca ctt ccc atg act cct att ctg gag ggt tct cac aga     1161
 Leu Thr Ser Pro Leu Pro Met Thr Pro Ile Leu Glu Gly Ser His Arg
 355                 360                 365                 370

 gct cat tcg ttg ctt ttt gaa aac agt gac agc ttt tct gag gac agc     1209
 Ala His Ser Leu Leu Phe Glu Asn Ser Asp Ser Phe Ser Glu Asp Ser
                 375                 380                 385

 agt acg ctg ggt cgg acc agg tct ctt ccc atc act att gaa atg cta     1257
 Ser Thr Leu Gly Arg Thr Arg Ser Leu Pro Ile Thr Ile Glu Met Leu
             390                 395                 400

 aaa gtt cca gac gat gaa gaa gaa gag gag caa acc tgt cca tcc aca     1305
 Lys Val Pro Asp Asp Glu Glu Glu Glu Glu Gln Thr Cys Pro Ser Thr
         405                 410                 415

 ttc agt gaa gaa atg aca cct acc tca gtc att cct aaa tta cca cag     1353
 Phe Ser Glu Glu Met Thr Pro Thr Ser Val Ile Pro Lys Leu Pro Gln
     420                 425                 430

 tgt cta cgg gag gaa gaa gag aag gag agc gac tct gat tca gaa ggt     1401
 Cys Leu Arg Glu Glu Glu Glu Lys Glu Ser Asp Ser Asp Ser Glu Gly
 435                 440                 445                 450

 ccc att cag tac cga gat gaa gaa gat gaa gat gaa agc tat cag agt     1449
 Pro Ile Gln Tyr Arg Asp Glu Glu Asp Glu Asp Glu Ser Tyr Gln Ser
                 455                 460                 465

 gct ctc gcc aac aaa gtg aag agg aaa gac aca ctg gca atg aag ttg     1497
 Ala Leu Ala Asn Lys Val Lys Arg Lys Asp Thr Leu Ala Met Lys Leu
             470                 475                 480

 aac cac aga ccc agt gaa cca gag ttg aac ctg aat tct tgg cct tgt     1545
 Asn His Arg Pro Ser Glu Pro Glu Leu Asn Leu Asn Ser Trp Pro Cys
         485                 490                 495

 aaa agc aag gag gag tgg aat gaa ata cgg cac cag att gga aac aca     1593
 Lys Ser Lys Glu Glu Trp Asn Glu Ile Arg His Gln Ile Gly Asn Thr
     500                 505                 510

 ctg atc cgg cga ctg agt caa aga cca aca cca gaa gaa cta gaa caa     1641
 Leu Ile Arg Arg Leu Ser Gln Arg Pro Thr Pro Glu Glu Leu Glu Gln
 515                 520                 525                 530

 cgc aat ata ttg caa cct aaa aat gaa gct gat cgt cag gca gaa aaa     1689
 Arg Asn Ile Leu Gln Pro Lys Asn Glu Ala Asp Arg Gln Ala Glu Lys
                 535                 540                 545

 cga gaa att aaa cgt cgg ctc act aga aag ctc agt caa agg cca act     1737
 Arg Glu Ile Lys Arg Arg Leu Thr Arg Lys Leu Ser Gln Arg Pro Thr
             550                 555                 560

 gtc gct gaa ctc ctt gcc agg aag att ctg agg ttt aat gaa tat gta     1785
 Val Ala Glu Leu Leu Ala Arg Lys Ile Leu Arg Phe Asn Glu Tyr Val
         565                 570                 575

 gag gta aca gat gct caa gat tat gac cgg cga gcc gac aaa cct tgg     1833
 Glu Val Thr Asp Ala Gln Asp Tyr Asp Arg Arg Ala Asp Lys Pro Trp
     580                 585                 590

 acc aaa ctg acc cct gct gac aag gct gcc ata aga aaa gaa tta aat     1881
 Thr Lys Leu Thr Pro Ala Asp Lys Ala Ala Ile Arg Lys Glu Leu Asn
 595                 600                 605                 610

 gaa ttt aaa agc tcc gag atg gag gtt cat gaa gag agc aaa cat ttt     1929
 Glu Phe Lys Ser Ser Glu Met Glu Val His Glu Glu Ser Lys His Phe
                 615                 620                 625

 aca cgc tac cat cgt cca tga tg ccaaaggttg agagaggaat caacatggct     1982
 Thr Arg Tyr His Arg Pro 
             630

 gctttgctgc ttccttctcc aaagtgacat atggagggaa ctttagcact tcccagcaca   2042

 gccagaattg catcctctgg gatcttctga ggtggacagc actttgaatg tagcatttca   2102

 ctggaacaga gtcttatgtg ctgcaccggg ggcaaaacaa cactttgtca gtgcttttga   2162

 acctttcaat attgtagcat gcttgaggag tttttccctt actggccacc aaagttctga   2222

 accacttgca ggttccaggt tttactggct gcaccacacc ccttccccta gatgactgcc   2282

 tgtgcagaga cacagtttgc accattagcc ttacctgccc tgccctgatt gtgagaccca   2342

 aatgtgtagg ctctaaattc cagccatcaa atccaattcc tggtggggaa aaccttctgg   2402

 agacccccaa ccttctgata aaagagtctc tacctccagg gaaagccttc ttaccacact   2462

 ggcatatcag atgaaagcat tgcactgtac ctctcgtaac acagcaatac agtcctcttg   2522

 aggcactcaa gcctgagagg aagctcagga tctgacatgt tcttcctttt cctcacaagt   2582

 catcatgatt ttttatttta aaataatctg gaagtaatgg gaacttagtt tttcctgaac   2642

 tccaaccaga atccaaattg                                               2662




      <210> 93
      <211> 2852
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(2819)

      <400> 93
 tttcgttggg atcccctcgg gctcccgcct tagcatgctg gccgggacat ctggtgaac      59                                                                 
 atg gcc tct gct act gcg gca gca gca cga cgg ggc ctc ggc cgg gct      107
 Met Ala Ser Ala Thr Ala Ala Ala Ala Arg Arg Gly Leu Gly Arg Ala
   1               5                  10                  15

 ctc cct ctc ctc tgg cgt ggc tac cag acc gag cgg ggc gtt tac ggc      155
 Leu Pro Leu Leu Trp Arg Gly Tyr Gln Thr Glu Arg Gly Val Tyr Gly
              20                  25                  30

 tac cgg ccg agg aag ccc gag agc cgc gag ccc cag ggc gcc ctg gag      203
 Tyr Arg Pro Arg Lys Pro Glu Ser Arg Glu Pro Gln Gly Ala Leu Glu
          35                  40                  45

 cgc ccc cca gtt gat cat ggc ctt gcc agg ttg gtg aca gta tat tgt      251
 Arg Pro Pro Val Asp His Gly Leu Ala Arg Leu Val Thr Val Tyr Cys
      50                  55                  60

 gag cat ggt cat aaa gct gcc aaa atc aac ccc ctc ttc acc gga caa      299
 Glu His Gly His Lys Ala Ala Lys Ile Asn Pro Leu Phe Thr Gly Gln
  65                  70                  75                  80

 gcc ctg ctg gag aat gtg cct gaa atc caa gcc ctg gtg cag aca ctg      347
 Ala Leu Leu Glu Asn Val Pro Glu Ile Gln Ala Leu Val Gln Thr Leu
                  85                  90                  95

 cag gga ccc ttc cac acg gca gga tta ttg aac atg ggg aag gaa gag      395
 Gln Gly Pro Phe His Thr Ala Gly Leu Leu Asn Met Gly Lys Glu Glu
             100                 105                 110

 gcc tca ctt gag gaa gtg tta gtc tat ctc aat caa atc tac tgt ggg      443
 Ala Ser Leu Glu Glu Val Leu Val Tyr Leu Asn Gln Ile Tyr Cys Gly
         115                 120                 125

 cag att tct att gaa acc tcc caa ctt cag agc cag gat gag aaa gac      491
 Gln Ile Ser Ile Glu Thr Ser Gln Leu Gln Ser Gln Asp Glu Lys Asp
     130                 135                 140

 tgg ttt gcc aag cgg ttt gag gaa ctg caa aag gag acg ttt acc aca      539
 Trp Phe Ala Lys Arg Phe Glu Glu Leu Gln Lys Glu Thr Phe Thr Thr
 145                 150                 155                 160

 gaa gag cga aaa cat ctg tcg aaa cta atg ctg gaa tct cag gag ttt      587
 Glu Glu Arg Lys His Leu Ser Lys Leu Met Leu Glu Ser Gln Glu Phe
                 165                 170                 175

 gac cac ttt ctg gcc acc aag ttc tcg aca gtg aag cga tat gga ggc      635
 Asp His Phe Leu Ala Thr Lys Phe Ser Thr Val Lys Arg Tyr Gly Gly
             180                 185                 190

 gaa ggg gct gaa agc atg atg ggc ttt ttc cac gag ctg ctg aaa atg      683
 Glu Gly Ala Glu Ser Met Met Gly Phe Phe His Glu Leu Leu Lys Met
         195                 200                 205

 tcg gcc tac agc ggg atc act gat gtc att att ggg atg ccc cat aga      731
 Ser Ala Tyr Ser Gly Ile Thr Asp Val Ile Ile Gly Met Pro His Arg
     210                 215                 220

 ggg agg ctg aat tta ttg aca ggc ctt ctg cag ttc cct cca gag ctg      779
 Gly Arg Leu Asn Leu Leu Thr Gly Leu Leu Gln Phe Pro Pro Glu Leu
 225                 230                 235                 240

 atg ttc cgt aaa atg cga ggc tta agt gaa ttt cca gag aat ttc tca      827
 Met Phe Arg Lys Met Arg Gly Leu Ser Glu Phe Pro Glu Asn Phe Ser
                 245                 250                 255

 gcc act gga gac gtc ctg tct cac ctg acc tcc tct gtg gac ctg gac      875
 Ala Thr Gly Asp Val Leu Ser His Leu Thr Ser Ser Val Asp Leu Asp
             260                 265                 270

 ttt ggg gcg cac cat ccc ctc cat gtg aca atg ttg ccc aat ccc tcg      923
 Phe Gly Ala His His Pro Leu His Val Thr Met Leu Pro Asn Pro Ser
         275                 280                 285

 cac ctg gag gcc gtc aac ccc gtg gcc gtg ggc aaa act cgc ggc agg      971
 His Leu Glu Ala Val Asn Pro Val Ala Val Gly Lys Thr Arg Gly Arg
     290                 295                 300

 cag cag tct cgc caa gac ggc gat tac tct cca gac aac tca gcc cag     1019
 Gln Gln Ser Arg Gln Asp Gly Asp Tyr Ser Pro Asp Asn Ser Ala Gln
 305                 310                 315                 320

 ccg ggg gac agg gtc att tgc tta cag gtc cat ggt gat gct tct ttc     1067
 Pro Gly Asp Arg Val Ile Cys Leu Gln Val His Gly Asp Ala Ser Phe
                 325                 330                 335

 tgt ggt caa ggg att gtt cct gaa aca ttc acg ctg tcc aat ctc cca     1115
 Cys Gly Gln Gly Ile Val Pro Glu Thr Phe Thr Leu Ser Asn Leu Pro
             340                 345                 350

 cat ttc aga att ggt ggg agt gtg cat ttg att gtt aat aac cag ctg     1163
 His Phe Arg Ile Gly Gly Ser Val His Leu Ile Val Asn Asn Gln Leu
         355                 360                 365

 ggt tac acc act cca gct gaa aga gga agg tct tct tta tac tgc agt     1211
 Gly Tyr Thr Thr Pro Ala Glu Arg Gly Arg Ser Ser Leu Tyr Cys Ser
     370                 375                 380

 gat att ggg aag ctt gtg ggc tgt gcc atc atc cat gtc aat gga gac     1259
 Asp Ile Gly Lys Leu Val Gly Cys Ala Ile Ile His Val Asn Gly Asp
 385                 390                 395                 400

 agc cca gag gaa gtg gtc cgt gcc aca cga ctg gct ttt gaa tac caa     1307
 Ser Pro Glu Glu Val Val Arg Ala Thr Arg Leu Ala Phe Glu Tyr Gln
                 405                 410                 415

 cgc cag ttc cgc aag gat gtg att att gat ctg ttg tgc tac agg cag     1355
 Arg Gln Phe Arg Lys Asp Val Ile Ile Asp Leu Leu Cys Tyr Arg Gln
             420                 425                 430

 tgg ggc cac aat gag ctg gat gag cca ttc tac acc aac ccc atc atg     1403
 Trp Gly His Asn Glu Leu Asp Glu Pro Phe Tyr Thr Asn Pro Ile Met
         435                 440                 445

 tac aaa atc atc aga gct cga aag agc att cca gac aca tat gca gag     1451
 Tyr Lys Ile Ile Arg Ala Arg Lys Ser Ile Pro Asp Thr Tyr Ala Glu
     450                 455                 460

 cac ctc att gct ggc gga ctc atg acg cag gag gag gtg tct gaa ata     1499
 His Leu Ile Ala Gly Gly Leu Met Thr Gln Glu Glu Val Ser Glu Ile
 465                 470                 475                 480

 aaa tcc tcc tac tat gcc aag ttg aat gat cac tta aat aac atg gcc     1547
 Lys Ser Ser Tyr Tyr Ala Lys Leu Asn Asp His Leu Asn Asn Met Ala
                 485                 490                 495

 cac tac agg ccc cct gcc ctg aac ctg cag gcc cac tgg cag ggc ctg     1595
 His Tyr Arg Pro Pro Ala Leu Asn Leu Gln Ala His Trp Gln Gly Leu
             500                 505                 510

 gct cag cca gaa gcg caa atc acc acc tgg agt aca ggt gtg ccc ctc     1643
 Ala Gln Pro Glu Ala Gln Ile Thr Thr Trp Ser Thr Gly Val Pro Leu
         515                 520                 525

 gac ctc ctg cgg ttt gtt ggc atg aag tct gta gag gtg cca aga gag     1691
 Asp Leu Leu Arg Phe Val Gly Met Lys Ser Val Glu Val Pro Arg Glu
     530                 535                 540

 ctg cag atg cac agt cac ctg ctg aag aca cat gtt cag tcc aga atg     1739
 Leu Gln Met His Ser His Leu Leu Lys Thr His Val Gln Ser Arg Met
 545                 550                 555                 560

 gag aag atg atg gac gga atc aag cta gac tgg gcc acc gcg gaa gct     1787
 Glu Lys Met Met Asp Gly Ile Lys Leu Asp Trp Ala Thr Ala Glu Ala
                 565                 570                 575

 ctt gcc ttg ggt tct tta ctt gct caa ggt ttt aat gtt cgt cta agt     1835
 Leu Ala Leu Gly Ser Leu Leu Ala Gln Gly Phe Asn Val Arg Leu Ser
             580                 585                 590

 ggc caa gat gtt ggt cgt gga act ttc agt cag agg cat gca atg gtg     1883
 Gly Gln Asp Val Gly Arg Gly Thr Phe Ser Gln Arg His Ala Met Val
         595                 600                 605

 gtt tgc cag gag acg gat gac acc tac atc ccc ctg aac cat atg gac     1931
 Val Cys Gln Glu Thr Asp Asp Thr Tyr Ile Pro Leu Asn His Met Asp
     610                 615                 620

 cca aat cag aag ggg ttt cta gag gtc agc aac agc ccc ctg tca gaa     1979
 Pro Asn Gln Lys Gly Phe Leu Glu Val Ser Asn Ser Pro Leu Ser Glu
 625                 630                 635                 640

 gag gcc gtc ctg gga ttc gaa tat ggg atg agc att gag agc cca aag     2027
 Glu Ala Val Leu Gly Phe Glu Tyr Gly Met Ser Ile Glu Ser Pro Lys
                 645                 650                 655

 tta ctg ccc ctg tgg gag gca cag ttt ggc gat ttc ttc aat ggt gcc     2075
 Leu Leu Pro Leu Trp Glu Ala Gln Phe Gly Asp Phe Phe Asn Gly Ala
             660                 665                 670

 cag atc atc ttt gac aca ttc atc tct gga gga gag gcc aag tgg ctc     2123
 Gln Ile Ile Phe Asp Thr Phe Ile Ser Gly Gly Glu Ala Lys Trp Leu
         675                 680                 685

 cta caa agc ggc att gtc atc ctc ctt cca cat ggc tac gat ggg gct     2171
 Leu Gln Ser Gly Ile Val Ile Leu Leu Pro His Gly Tyr Asp Gly Ala
     690                 695                 700

 ggg cca gac cac tca tcc tgt cga ata gag cgt ttc ctg cag atg tgt     2219
 Gly Pro Asp His Ser Ser Cys Arg Ile Glu Arg Phe Leu Gln Met Cys
 705                 710                 715                 720

 gac agt gcg gaa gag ggg gtg gac gga gac act gtg aac atg ttt gtg     2267
 Asp Ser Ala Glu Glu Gly Val Asp Gly Asp Thr Val Asn Met Phe Val
                 725                 730                 735

 gtt cac cca aca act cct gca cag tat ttc cac ttg ctt agg aga cag     2315
 Val His Pro Thr Thr Pro Ala Gln Tyr Phe His Leu Leu Arg Arg Gln
             740                 745                 750

 atg gtc cgg aac ttc aga aaa cca ctc att gtt gct tcc cct aag atg     2363
 Met Val Arg Asn Phe Arg Lys Pro Leu Ile Val Ala Ser Pro Lys Met
         755                 760                 765

 tta ctc agg ctc ccg gca gcc gtg tca act ctt caa gaa atg gca cca     2411
 Leu Leu Arg Leu Pro Ala Ala Val Ser Thr Leu Gln Glu Met Ala Pro
     770                 775                 780

 gga aca aca ttt aac ccg gtc att ggt gat tca tct gtg gat cca aaa     2459
 Gly Thr Thr Phe Asn Pro Val Ile Gly Asp Ser Ser Val Asp Pro Lys
 785                 790                 795                 800

 aag gtt aag acc ctc gtg ttc tgc tcc ggc aaa cat ttc tac tcc ctg     2507
 Lys Val Lys Thr Leu Val Phe Cys Ser Gly Lys His Phe Tyr Ser Leu
                 805                 810                 815

 gtg aaa caa aga gaa tct ctg ggg gcc aag aag cat gac ttt gcc atc     2555
 Val Lys Gln Arg Glu Ser Leu Gly Ala Lys Lys His Asp Phe Ala Ile
             820                 825                 830

 atc cga gta gag gaa ctc tgc ccc ttc ccg ttg gat tct tta cag caa     2603
 Ile Arg Val Glu Glu Leu Cys Pro Phe Pro Leu Asp Ser Leu Gln Gln
         835                 840                 845

 gag atg agc aaa tac aaa cat gtt aaa gat cat att tgg agt cag gag     2651
 Glu Met Ser Lys Tyr Lys His Val Lys Asp His Ile Trp Ser Gln Glu
     850                 855                 860

 gaa cct cag aac atg ggt ccg tgg tcg ttt gtt tct cca agg ttt gaa     2699
 Glu Pro Gln Asn Met Gly Pro Trp Ser Phe Val Ser Pro Arg Phe Glu
 865                 870                 875                 880

 aag cag ctg gcc tgc aag ctc cgt ctg gtg ggc cgg ccc cct ttg cca     2747
 Lys Gln Leu Ala Cys Lys Leu Arg Leu Val Gly Arg Pro Pro Leu Pro
                 885                 890                 895

 gta ccc gct gta gga att ggc aca gtt cac ttg cac cag cat gaa gat     2795
 Val Pro Ala Val Gly Ile Gly Thr Val His Leu His Gln His Glu Asp
             900                 905                 910

 atc ctc gcc aag acc ttc gct tga tgatgacttt tgaagaaaca ctatttctct    2849
 Ile Leu Ala Lys Thr Phe Ala 
         915

 tta                                                                 2852




      <210> 94
      <211> 2313
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2259)

      <400> 94
  atg att tac acc aag gga gcc ccc aac agc tac ccc cct gtt ttc act      48
  Met Ile Tyr Thr Lys Gly Ala Pro Asn Ser Tyr Pro Pro Val Phe Thr
    1               5                  10                  15

 gct cct tct ccg caa ctg tgg gtg gat ggg act gtt aag ccc atg ggc       96
 Ala Pro Ser Pro Gln Leu Trp Val Asp Gly Thr Val Lys Pro Met Gly
              20                  25                  30

 atc ttc tct gag gaa tta agg agg ggt att ggt gaa ggg ttg aga gcc      144
 Ile Phe Ser Glu Glu Leu Arg Arg Gly Ile Gly Glu Gly Leu Arg Ala
          35                  40                  45

 tgg gtc tgg cag gtg ctg gct gtc tgg tcc ctc cac ctc tgt aac cct      192
 Trp Val Trp Gln Val Leu Ala Val Trp Ser Leu His Leu Cys Asn Pro
      50                  55                  60

 tct tgt gga gga gtg acc ggt gag ctg ctg gtt ctg gca gtc aca aaa      240
 Ser Cys Gly Gly Val Thr Gly Glu Leu Leu Val Leu Ala Val Thr Lys
  65                  70                  75                  80

 ctg gga acc cgg gca cag gcc atg gtc aca cag ccc acc ctc agc ttt      288
 Leu Gly Thr Arg Ala Gln Ala Met Val Thr Gln Pro Thr Leu Ser Phe
                  85                  90                  95

 act ttc tcc att ggc tcc ggc cct agc agg cat gtg agt gtg cac ctc      336
 Thr Phe Ser Ile Gly Ser Gly Pro Ser Arg His Val Ser Val His Leu
             100                 105                 110

 cta ctc tgg gcc cag aat tcc tgg agc ttt tac tcc tta tca aac ctt      384
 Leu Leu Trp Ala Gln Asn Ser Trp Ser Phe Tyr Ser Leu Ser Asn Leu
         115                 120                 125

 aaa gcc ctt atg ggc ttt tct gtg ccc gtg tct ggg gct ggc cag ggc      432
 Lys Ala Leu Met Gly Phe Ser Val Pro Val Ser Gly Ala Gly Gln Gly
     130                 135                 140

 ccc cag aag tac agc ctg cac cca gca cca atg acc acc ctc acg tgt      480
 Pro Gln Lys Tyr Ser Leu His Pro Ala Pro Met Thr Thr Leu Thr Cys
 145                 150                 155                 160

 tgg tct cta aat ttg gtg ccc aat ata gag gag gca gag gca gat aaa      528
 Trp Ser Leu Asn Leu Val Pro Asn Ile Glu Glu Ala Glu Ala Asp Lys
                 165                 170                 175

 cat ggt ggt gtt gaa gta ccc tgg tct gtg tgg ccc tgg aat gcc aag      576
 His Gly Gly Val Glu Val Pro Trp Ser Val Trp Pro Trp Asn Ala Lys
             180                 185                 190

 aag cat gtg cgg ctg cgt gag cat gca gcc aca ctg gag gag gag ctg      624
 Lys His Val Arg Leu Arg Glu His Ala Ala Thr Leu Glu Glu Glu Leu
         195                 200                 205

 gcc ctc agc cga cag gcc aca gag cca gcc cca gca ctg agg atc gac      672
 Ala Leu Ser Arg Gln Ala Thr Glu Pro Ala Pro Ala Leu Arg Ile Asp
     210                 215                 220

 tac ccg aag gca ctg cag atc ctg atg gag ggc ggc aca cac atg gtg      720
 Tyr Pro Lys Ala Leu Gln Ile Leu Met Glu Gly Gly Thr His Met Val
 225                 230                 235                 240

 tgc acg ggc cgc acg cac aca gac cgc atc tgc cgc ttc aag tgg ctc      768
 Cys Thr Gly Arg Thr His Thr Asp Arg Ile Cys Arg Phe Lys Trp Leu
                 245                 250                 255

 tgc tac tcc aac gag gct gag gag ttc atc ttc ttc cat ggc aac acc      816
 Cys Tyr Ser Asn Glu Ala Glu Glu Phe Ile Phe Phe His Gly Asn Thr
             260                 265                 270

 tct gtc atg ctg ccc aac ctg ggc tcc cgg cgc ttc cag cca gcc ctg      864
 Ser Val Met Leu Pro Asn Leu Gly Ser Arg Arg Phe Gln Pro Ala Leu
         275                 280                 285

 ctc gac cta tcc acc gtg gag gac cac aac act cag tac ttc aac ttc      912
 Leu Asp Leu Ser Thr Val Glu Asp His Asn Thr Gln Tyr Phe Asn Phe
     290                 295                 300

 gtg gag ctg cct gct gct gcc ctg cgc ttc atg ccc aag ccg gtg ttc      960
 Val Glu Leu Pro Ala Ala Ala Leu Arg Phe Met Pro Lys Pro Val Phe
 305                 310                 315                 320

 gtg cca gac gtg gcc ctc atc gcc aac cgc ttc aac ccc gac aac ctc     1008
 Val Pro Asp Val Ala Leu Ile Ala Asn Arg Phe Asn Pro Asp Asn Leu
                 325                 330                 335

 atg cac gtc ttt cat gac gac ctg ctg cca ctc ttc tac acc ctg cgg     1056
 Met His Val Phe His Asp Asp Leu Leu Pro Leu Phe Tyr Thr Leu Arg
             340                 345                 350

 cag ttt ccc ggc ctg gcc cac gag gca cgg ctc ttc ttc atg gag ggc     1104
 Gln Phe Pro Gly Leu Ala His Glu Ala Arg Leu Phe Phe Met Glu Gly
         355                 360                 365

 tgg ggc gag ggt gca cac ttc gac ctc tac aag ctg ctc agc ccc aag     1152
 Trp Gly Glu Gly Ala His Phe Asp Leu Tyr Lys Leu Leu Ser Pro Lys
     370                 375                 380

 cag cct ctc ctg cgg gca cag ctg aag acc ctg ggc cgg ctg ctg tgc     1200
 Gln Pro Leu Leu Arg Ala Gln Leu Lys Thr Leu Gly Arg Leu Leu Cys
 385                 390                 395                 400

 ttc tcc cat gct ttt gtg ggc ctc tcc aag atc act acc tgg tac cag     1248
 Phe Ser His Ala Phe Val Gly Leu Ser Lys Ile Thr Thr Trp Tyr Gln
                 405                 410                 415

 tat ggc ttt gtg cag ccc cag ggc ccg aag gcc aac atc ctc gtc tca     1296
 Tyr Gly Phe Val Gln Pro Gln Gly Pro Lys Ala Asn Ile Leu Val Ser
             420                 425                 430

 ggc aat gag atc cgg cag ttt gca cgg ttc atg aca gaa aag ctg aac     1344
 Gly Asn Glu Ile Arg Gln Phe Ala Arg Phe Met Thr Glu Lys Leu Asn
         435                 440                 445

 gtg agc cac aca gga gtc ccc cta ggc gag gag tac att ctg gtc ttt     1392
 Val Ser His Thr Gly Val Pro Leu Gly Glu Glu Tyr Ile Leu Val Phe
     450                 455                 460

 agc cga acc cag aac aga ctc att ctg aat gag gca gag ctg ctg ctg     1440
 Ser Arg Thr Gln Asn Arg Leu Ile Leu Asn Glu Ala Glu Leu Leu Leu
 465                 470                 475                 480

 gca ctg gcc cag gag ttc cag atg aag aca gtg aca gtg tcc ctg gag     1488
 Ala Leu Ala Gln Glu Phe Gln Met Lys Thr Val Thr Val Ser Leu Glu
                 485                 490                 495

 gac cac acc ttt gct gat gtc gtg cgg ctg gtc agc aat gcc tcc atg     1536
 Asp His Thr Phe Ala Asp Val Val Arg Leu Val Ser Asn Ala Ser Met
             500                 505                 510

 ctg gtc agc atg cat ggg gcc cag ctg gtc acc acc ctc ttc ctg ccc     1584
 Leu Val Ser Met His Gly Ala Gln Leu Val Thr Thr Leu Phe Leu Pro
         515                 520                 525

 cgt ggg gca act gtg gta gag ctc ttc cca tat gct gtc aat ccc gac     1632
 Arg Gly Ala Thr Val Val Glu Leu Phe Pro Tyr Ala Val Asn Pro Asp
     530                 535                 540

 cac tac act ccc tat aag acg ctg gcc atg ctg cct ggc atg gac ctc     1680
 His Tyr Thr Pro Tyr Lys Thr Leu Ala Met Leu Pro Gly Met Asp Leu
 545                 550                 555                 560

 cag tat gta gcc tgg cgg aac atg atg cca gag aac aca gtc aca cac     1728
 Gln Tyr Val Ala Trp Arg Asn Met Met Pro Glu Asn Thr Val Thr His
                 565                 570                 575

 cct gag cgg ccc tgg gat cag ggg ggc atc acc cat ctg gac cgg gct     1776
 Pro Glu Arg Pro Trp Asp Gln Gly Gly Ile Thr His Leu Asp Arg Ala
             580                 585                 590

 gag caa gcc cgt atc ctg caa agc cgt gag gtc cca cgg cat ctc tgt     1824
 Glu Gln Ala Arg Ile Leu Gln Ser Arg Glu Val Pro Arg His Leu Cys
         595                 600                 605

 tgc cgg aac ccc gag tgg ctc ttc cga atc tac cag gac acc aag gtg     1872
 Cys Arg Asn Pro Glu Trp Leu Phe Arg Ile Tyr Gln Asp Thr Lys Val
     610                 615                 620

 gac atc cca tcc ctc att caa acc ata cgg cgc gtg gtg aag ggc cgg     1920
 Asp Ile Pro Ser Leu Ile Gln Thr Ile Arg Arg Val Val Lys Gly Arg
 625                 630                 635                 640

 cca gga cca cgg aag cag aag tgg aca gtc ggc cta tat cca ggc aag     1968
 Pro Gly Pro Arg Lys Gln Lys Trp Thr Val Gly Leu Tyr Pro Gly Lys
                 645                 650                 655

 gtg cgg gag gca cgg tgc cag gcg tca gtg cat ggc gcc tcc gag gcc     2016
 Val Arg Glu Ala Arg Cys Gln Ala Ser Val His Gly Ala Ser Glu Ala
             660                 665                 670

 cgc ctc act gtc tcc tgg cag atc cca tgg aac ctt aaa tac ctg aag     2064
 Arg Leu Thr Val Ser Trp Gln Ile Pro Trp Asn Leu Lys Tyr Leu Lys
         675                 680                 685

 gtg agg gag gtg aag tac gag gtg tgg ctg cag gag cag ggg gag aac     2112
 Val Arg Glu Val Lys Tyr Glu Val Trp Leu Gln Glu Gln Gly Glu Asn
     690                 695                 700

 acc tac gtg cct tac atc ctg gct ctg cag aac cac acc ttc act gag     2160
 Thr Tyr Val Pro Tyr Ile Leu Ala Leu Gln Asn His Thr Phe Thr Glu
 705                 710                 715                 720

 aac atc aag ccc ttc acc acc tac ctg gtg tgg gtc cgc tgc atc ttc     2208
 Asn Ile Lys Pro Phe Thr Thr Tyr Leu Val Trp Val Arg Cys Ile Phe
                 725                 730                 735

 aac aag atc ctc ctg gga ccc ttt gca gat gtg ctg gtg tgc aac acg     2256
 Asn Lys Ile Leu Leu Gly Pro Phe Ala Asp Val Leu Val Cys Asn Thr
             740                 745                 750

 tag cgag caggccacag cctggcctcg ggaaggtggc tcctgcagtt cagcgtccct     2313
 






      <210> 95
      <211> 2698
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (310)..(2241)

      <400> 95
 tttcgtgcgg ctctggcggt cgtggcggtc ggagatccga gagctctgct tctctgaaaa     60

 gcgtgtggct ttctggactt ggtctacacc tgacagtcac tggaatgcta ctccaggcct    120

 tagaagaaag tgaaactaat tttaaaggcc ccttattctt tctgttacct gcctgctgaa    180

 gtgaaaataa atctccctgc tcctttattc taaactgatt ttactttccc atctcaaaaa    240

 cgtgtgcagg gagcaggagc cctcctaccc gagccccagc tgtattggaa accctcctaa    300

 gtcagagtg    atg ggt cag gaa tct agc aag cct gta tgg ccc aat cca     348
              Met Gly Gln Glu Ser Ser Lys Pro Val Trp Pro Asn Pro
                1               5                  10

 aca gga ggg tat cag tcc aat aca ggt agg agg tat gga aga agg cat      396
 Thr Gly Gly Tyr Gln Ser Asn Thr Gly Arg Arg Tyr Gly Arg Arg His
      15                  20                  25

 gct tat gtc agt ttc agg cca ccc acg agc cag cgg gaa agg att gcc      444
 Ala Tyr Val Ser Phe Arg Pro Pro Thr Ser Gln Arg Glu Arg Ile Ala
  30                  35                  40                  45

 agc cag aga aag acg aac tcc gaa gtc cca atg cac aga tca gcc ccc      492
 Ser Gln Arg Lys Thr Asn Ser Glu Val Pro Met His Arg Ser Ala Pro
                  50                  55                  60

 agt caa acc acc aag agg agc cga tcg cca ttt tcc act act cgt cgt      540
 Ser Gln Thr Thr Lys Arg Ser Arg Ser Pro Phe Ser Thr Thr Arg Arg
              65                  70                  75

 agt tgg gac gac agc gag agt tcg gga acc aac ctg aat att gat aat      588
 Ser Trp Asp Asp Ser Glu Ser Ser Gly Thr Asn Leu Asn Ile Asp Asn
          80                  85                  90

 gag gac tat tcc agg tat ccg cca aga gag tac aga gct tcg ggt agc      636
 Glu Asp Tyr Ser Arg Tyr Pro Pro Arg Glu Tyr Arg Ala Ser Gly Ser
      95                 100                 105

 aga aga gga atg gcc tat gga cat att gac tct tat ggg gca gat gat      684
 Arg Arg Gly Met Ala Tyr Gly His Ile Asp Ser Tyr Gly Ala Asp Asp
 110                 115                 120                 125

 agt gag gag gag ggg gct ggg cct gtt gag cga ccg cca gtg aga ggg      732
 Ser Glu Glu Glu Gly Ala Gly Pro Val Glu Arg Pro Pro Val Arg Gly
                 130                 135                 140

 aaa act ggc aag ttt aaa gat gat aag ctg tat gac cca gag aaa ggg      780
 Lys Thr Gly Lys Phe Lys Asp Asp Lys Leu Tyr Asp Pro Glu Lys Gly
             145                 150                 155

 gca agg tct ttg gct ggg cca cct cca cat ttc tct agt ttt agc cgt      828
 Ala Arg Ser Leu Ala Gly Pro Pro Pro His Phe Ser Ser Phe Ser Arg
         160                 165                 170

 gat gtg aga gag gag cga gac aag tta gac cca gtc cct gca gca aga      876
 Asp Val Arg Glu Glu Arg Asp Lys Leu Asp Pro Val Pro Ala Ala Arg
     175                 180                 185

 tgc tca gct agc aga gct gac ttc ctg cca caa agt agt gtg gcc tca      924
 Cys Ser Ala Ser Arg Ala Asp Phe Leu Pro Gln Ser Ser Val Ala Ser
 190                 195                 200                 205

 cag tcg tct tct gaa ggc aag ctg gct aca aaa ggt gac agc tcg gag      972
 Gln Ser Ser Ser Glu Gly Lys Leu Ala Thr Lys Gly Asp Ser Ser Glu
                 210                 215                 220

 agg gag aga agg gag caa aat tta cct gca cgt ccc agc agg gct cct     1020
 Arg Glu Arg Arg Glu Gln Asn Leu Pro Ala Arg Pro Ser Arg Ala Pro
             225                 230                 235

 gtg agt att tgt ggt ggt ggg gaa aac acc tca aag agt gca gag gaa     1068
 Val Ser Ile Cys Gly Gly Gly Glu Asn Thr Ser Lys Ser Ala Glu Glu
         240                 245                 250

 cct gtg gtc agg ccc aaa atc aga aac ctg gca agt cca aac tgc gtg     1116
 Pro Val Val Arg Pro Lys Ile Arg Asn Leu Ala Ser Pro Asn Cys Val
     255                 260                 265

 aaa cca aaa att ttt ttt gat act gat gat gat gac gat atg cca cac     1164
 Lys Pro Lys Ile Phe Phe Asp Thr Asp Asp Asp Asp Asp Met Pro His
 270                 275                 280                 285

 agt act tcc agg tgg agg gat acc gcc aat gac aat gag ggc cac tcg     1212
 Ser Thr Ser Arg Trp Arg Asp Thr Ala Asn Asp Asn Glu Gly His Ser
                 290                 295                 300

 gat ggc ctg gca aga aga ggg aga ggc gag agt tca agt ggc tat ccc     1260
 Asp Gly Leu Ala Arg Arg Gly Arg Gly Glu Ser Ser Ser Gly Tyr Pro
             305                 310                 315

 gag cca aag tac cct gaa gac aaa cgg gaa gcg agg agt gac caa gtg     1308
 Glu Pro Lys Tyr Pro Glu Asp Lys Arg Glu Ala Arg Ser Asp Gln Val
         320                 325                 330

 aaa cca gaa aag gtg ccg aga cga cga cgc acc atg gcc gac cct gac     1356
 Lys Pro Glu Lys Val Pro Arg Arg Arg Arg Thr Met Ala Asp Pro Asp
     335                 340                 345

 ttc tgg acg cac agt gat gat tac tac aaa tac tgc gac gaa gac tct     1404
 Phe Trp Thr His Ser Asp Asp Tyr Tyr Lys Tyr Cys Asp Glu Asp Ser
 350                 355                 360                 365

 gac agt gac aaa gag tgg att gct gct ctg cgt cgg aaa tat cga agc     1452
 Asp Ser Asp Lys Glu Trp Ile Ala Ala Leu Arg Arg Lys Tyr Arg Ser
                 370                 375                 380

 cga gag caa acc ctg tcc tcc agt ggc gaa agc tgg gag act ctg ccg     1500
 Arg Glu Gln Thr Leu Ser Ser Ser Gly Glu Ser Trp Glu Thr Leu Pro
             385                 390                 395

 ggg aaa gaa gag cgg gaa cct cca cag gct aag gtg agt gcc agc act     1548
 Gly Lys Glu Glu Arg Glu Pro Pro Gln Ala Lys Val Ser Ala Ser Thr
         400                 405                 410

 ggc acc agc cct ggc ccc ggt gct agt gcc agt gcc ggg gct ggc gcc     1596
 Gly Thr Ser Pro Gly Pro Gly Ala Ser Ala Ser Ala Gly Ala Gly Ala
     415                 420                 425

 ggg gcc aat gct ggc agc aat ggc agc aat tac ctt gaa gaa gtt cga     1644
 Gly Ala Asn Ala Gly Ser Asn Gly Ser Asn Tyr Leu Glu Glu Val Arg
 430                 435                 440                 445

 gaa cca tct ctt cag gaa gag cag gca tcc ctg gaa gaa gga gaa att     1692
 Glu Pro Ser Leu Gln Glu Glu Gln Ala Ser Leu Glu Glu Gly Glu Ile
                 450                 455                 460

 cct tgg ctc cag tac cat gag aat gac agt agc agt gag ggg gat aat     1740
 Pro Trp Leu Gln Tyr His Glu Asn Asp Ser Ser Ser Glu Gly Asp Asn
             465                 470                 475

 gat tct ggt cac gag ttg atg caa cct ggg gta ttc atg ctg gat gga     1788
 Asp Ser Gly His Glu Leu Met Gln Pro Gly Val Phe Met Leu Asp Gly
         480                 485                 490

 aac aac aac ctt gaa gat gac tcc agt gtg agc gaa gac cta gaa gtg     1836
 Asn Asn Asn Leu Glu Asp Asp Ser Ser Val Ser Glu Asp Leu Glu Val
     495                 500                 505

 gat tgg agc ctc ttt gat gga ttt gca gat ggg tta gga gtg gct gaa     1884
 Asp Trp Ser Leu Phe Asp Gly Phe Ala Asp Gly Leu Gly Val Ala Glu
 510                 515                 520                 525

 gcc att tcc tat gtg gac cct cag ttc ctc acc tac atg gca ctt gaa     1932
 Ala Ile Ser Tyr Val Asp Pro Gln Phe Leu Thr Tyr Met Ala Leu Glu
                 530                 535                 540

 gaa cgc ctg gcc cag gca atg gaa act gcc ctt gcg cac ttg gag tct     1980
 Glu Arg Leu Ala Gln Ala Met Glu Thr Ala Leu Ala His Leu Glu Ser
             545                 550                 555

 ctc gca gtg gat gta gag gtg gcc aat cca cca gca agc aag gag agc     2028
 Leu Ala Val Asp Val Glu Val Ala Asn Pro Pro Ala Ser Lys Glu Ser
         560                 565                 570

 att gac gct ctt ccc gag atc ctg gtc act gaa gat cat ggc gca gtt     2076
 Ile Asp Ala Leu Pro Glu Ile Leu Val Thr Glu Asp His Gly Ala Val
     575                 580                 585

 ggt cag gag atg tgc tgc ccc atc tgc tgt agc gaa tat gtg aag ggg     2124
 Gly Gln Glu Met Cys Cys Pro Ile Cys Cys Ser Glu Tyr Val Lys Gly
 590                 595                 600                 605

 gag gtg gca act gag ctg ccg tgc cac cac tat ttc cac aag ccg tgt     2172
 Glu Val Ala Thr Glu Leu Pro Cys His His Tyr Phe His Lys Pro Cys
                 610                 615                 620

 gtg tcc atc tgg ctt cag aag tca ggc acc tgc ccc gtg tgc cgc tgc     2220
 Val Ser Ile Trp Leu Gln Lys Ser Gly Thr Cys Pro Val Cys Arg Cys
             625                 630                 635

 atg ttc cct ccc cca ctc taa ag accaaggccg tttactcctg gtctgattat     2273
 Met Phe Pro Pro Pro Leu 
         640

 tttccccatc tgaaatccac aatactgcag gagccctctt gaaattaaca atggaaataa   2333

 aaccaatcag tcagttagcc taaacctatt gattcctcgt gattatttcc aatgtgaaaa   2393

 cagttgtgta tgattgcatt aaaaatcata tcatctttta gaggttagaa aagggaaaac   2453

 taaactttct aaatgctact tgagattgca gtaagaagat acgttttcta acctgaaagt   2513

 taaatcgcat ttgttttctt cagtagaatg ggaatgtgtt gctgttactt gtaatgtcaa   2573

 gtttatctgt taaatatgtc caaaaggcaa aatcattttt gttgcatgtt atgggtcgat   2633

 gttcctgtaa ttgcagtgcc gtaaaagctt attaaagttg ttcttttggt tttaaaaaaa   2693

 aaaaa                                                               2698




      <210> 96
      <211> 8538
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(7020)

      <400> 96
 ttacaccaac tgcagtgtga atggaagacc cggaacctgt catcccagct gcagactgga     60

 agagacctgg aagatgaagt cgttgtcagc tactctcatc ctcacgtcag gctgcttcgc    120

 caaagg   atg gat cgg ctg gat aat tta acc tgt cac ctg ttg aag aaa     168
          Met Asp Arg Leu Asp Asn Leu Thr Cys His Leu Leu Lys Lys
            1               5                  10

 cag gcc ttt aga ccc cag ctg cct gcc tac gag tcc ctg gtt cag gag      216
 Gln Ala Phe Arg Pro Gln Leu Pro Ala Tyr Glu Ser Leu Val Gln Glu
  15                  20                  25                  30

 atc cac cac tac gtc acc agc atc gcc aag gcc cct gct gtt cag gat      264
 Ile His His Tyr Val Thr Ser Ile Ala Lys Ala Pro Ala Val Gln Asp
                  35                  40                  45

 ctg ctc aca cgg ctt ctg cag gcc ctc cac ata gat ggg cca cgg tct      312
 Leu Leu Thr Arg Leu Leu Gln Ala Leu His Ile Asp Gly Pro Arg Ser
              50                  55                  60

 gcc caa gta gcc cag agc ctt cta aag gag gag gcc tct tgg cag cag      360
 Ala Gln Val Ala Gln Ser Leu Leu Lys Glu Glu Ala Ser Trp Gln Gln
          65                  70                  75

 tca cac cac cag ttc cgg aag cgg ctg tca gag gag tac acc ttc tat      408
 Ser His His Gln Phe Arg Lys Arg Leu Ser Glu Glu Tyr Thr Phe Tyr
      80                  85                  90

 cca gat gcc gtg agc cca ctg cag gca tcc ata ttg cag tta caa cat      456
 Pro Asp Ala Val Ser Pro Leu Gln Ala Ser Ile Leu Gln Leu Gln His
  95                 100                 105                 110

 ggc atg agg ctg gtg gcc tct gag ctc cac acc tca ctc cac agc agt      504
 Gly Met Arg Leu Val Ala Ser Glu Leu His Thr Ser Leu His Ser Ser
                 115                 120                 125

 atg gtt ggt gca gac agg ctg ggg acc ctg gcc aca gcc ttg ctg gct      552
 Met Val Gly Ala Asp Arg Leu Gly Thr Leu Ala Thr Ala Leu Leu Ala
             130                 135                 140

 ttc cca tcg gtg ggc ccc acc ttc ccg act tac tat gct cat gca gac      600
 Phe Pro Ser Val Gly Pro Thr Phe Pro Thr Tyr Tyr Ala His Ala Asp
         145                 150                 155

 act ttg tgc tcg gtg aag tct gag gag gtt cta cga ggc ctt ggg aag      648
 Thr Leu Cys Ser Val Lys Ser Glu Glu Val Leu Arg Gly Leu Gly Lys
     160                 165                 170

 cta atc ctc aag cgc tca gga gga aag gag ctg gaa ggc aag ggc cag      696
 Leu Ile Leu Lys Arg Ser Gly Gly Lys Glu Leu Glu Gly Lys Gly Gln
 175                 180                 185                 190

 aaa gcc tgt ccc act cgg gag cag ctg ctg atg aat gct ctc ctt tac      744
 Lys Ala Cys Pro Thr Arg Glu Gln Leu Leu Met Asn Ala Leu Leu Tyr
                 195                 200                 205

 ctg cgc tcc cac gtg tta tgc aag gga gag ttg gac cag agg gcc ctg      792
 Leu Arg Ser His Val Leu Cys Lys Gly Glu Leu Asp Gln Arg Ala Leu
             210                 215                 220

 cag ctc ttc aga cat gtg tgt cag gaa atc atc agt gag tgg gat gag      840
 Gln Leu Phe Arg His Val Cys Gln Glu Ile Ile Ser Glu Trp Asp Glu
         225                 230                 235

 cag gaa cgc ata gcc caa gag aag gct gag cag gaa agc ggc ctg tat      888
 Gln Glu Arg Ile Ala Gln Glu Lys Ala Glu Gln Glu Ser Gly Leu Tyr
     240                 245                 250

 aga tac agg agc agg aac tct agg aca gcc ctg agt gaa gag gag gag      936
 Arg Tyr Arg Ser Arg Asn Ser Arg Thr Ala Leu Ser Glu Glu Glu Glu
 255                 260                 265                 270

 gaa gaa cgg gag ttc aga aaa cag ttc ccc ctg cat gaa aag gac ttt      984
 Glu Glu Arg Glu Phe Arg Lys Gln Phe Pro Leu His Glu Lys Asp Phe
                 275                 280                 285

 gca gat att ttg gtg cag cca acg ttg gag gag aac aaa gga act tca     1032
 Ala Asp Ile Leu Val Gln Pro Thr Leu Glu Glu Asn Lys Gly Thr Ser
             290                 295                 300

 gat ggg caa gaa gag gaa gca ggc aca aac cca gct ctc ctc tcc cag     1080
 Asp Gly Gln Glu Glu Glu Ala Gly Thr Asn Pro Ala Leu Leu Ser Gln
         305                 310                 315

 aat tca atg cag gca gta atg ctg ata cac cag caa ttg tgt ctc aac     1128
 Asn Ser Met Gln Ala Val Met Leu Ile His Gln Gln Leu Cys Leu Asn
     320                 325                 330

 ttt gct cga tcc ctc tgg tat caa cag act ctg ccg cca cat gaa gca     1176
 Phe Ala Arg Ser Leu Trp Tyr Gln Gln Thr Leu Pro Pro His Glu Ala
 335                 340                 345                 350

 aag cat tac ctc agc ctg ttt ctg tct tgc tat cag act ggg gca tcg     1224
 Lys His Tyr Leu Ser Leu Phe Leu Ser Cys Tyr Gln Thr Gly Ala Ser
                 355                 360                 365

 ctt gtg aca cac ttc tac ccc ctg atg gga gtt gaa ctg aat gac cga     1272
 Leu Val Thr His Phe Tyr Pro Leu Met Gly Val Glu Leu Asn Asp Arg
             370                 375                 380

 ctc ttg ggc agc caa ctt ttg gcc tgt acc ctc tcc cat aac act ctt     1320
 Leu Leu Gly Ser Gln Leu Leu Ala Cys Thr Leu Ser His Asn Thr Leu
         385                 390                 395

 ttt ggg gag gca ccc tca gac ctg atg gtg aaa cct gat ggg ccc tat     1368
 Phe Gly Glu Ala Pro Ser Asp Leu Met Val Lys Pro Asp Gly Pro Tyr
     400                 405                 410

 gac ttc tac cag cat ccc aat gtt cca gaa gca cgg cag tgt caa cct     1416
 Asp Phe Tyr Gln His Pro Asn Val Pro Glu Ala Arg Gln Cys Gln Pro
 415                 420                 425                 430

 gtg ctt caa ggt ttc tca gag gct gtc agt cac ttg cta cag gac tgg     1464
 Val Leu Gln Gly Phe Ser Glu Ala Val Ser His Leu Leu Gln Asp Trp
                 435                 440                 445

 cca gaa cac cca gcg ctt gaa cag ctc ctg gtt gta atg gac aga att     1512
 Pro Glu His Pro Ala Leu Glu Gln Leu Leu Val Val Met Asp Arg Ile
             450                 455                 460

 cgt agt ttc cca ctt tcc agt ccc atc tca aag ttc ctg aat ggc tta     1560
 Arg Ser Phe Pro Leu Ser Ser Pro Ile Ser Lys Phe Leu Asn Gly Leu
         465                 470                 475

 gag atc ctt ctg gca aag gca cag gat tgg gag gaa aat gca agt cga     1608
 Glu Ile Leu Leu Ala Lys Ala Gln Asp Trp Glu Glu Asn Ala Ser Arg
     480                 485                 490

 gct ttg tct ttg cgg aaa cat ctt gat ttg atc agt cag atg atc att     1656
 Ala Leu Ser Leu Arg Lys His Leu Asp Leu Ile Ser Gln Met Ile Ile
 495                 500                 505                 510

 cgg tgg cgt aaa ctg gag ctg aac tgc tgg tcc atg agt ttg gat aat     1704
 Arg Trp Arg Lys Leu Glu Leu Asn Cys Trp Ser Met Ser Leu Asp Asn
                 515                 520                 525

 act atg aag cgc cac acc gag aaa tcc acc aag cac tgg ttc tcc atc     1752
 Thr Met Lys Arg His Thr Glu Lys Ser Thr Lys His Trp Phe Ser Ile
             530                 535                 540

 tat cag atg ctt gag aag cac atg cag gaa caa aca gaa gaa cag gaa     1800
 Tyr Gln Met Leu Glu Lys His Met Gln Glu Gln Thr Glu Glu Gln Glu
         545                 550                 555

 gat gac aaa cag atg acc ttg atg ttg ctg gtc agc aca tta caa gca     1848
 Asp Asp Lys Gln Met Thr Leu Met Leu Leu Val Ser Thr Leu Gln Ala
     560                 565                 570

 ttt att gaa gga tcc tcg ctg gga gag ttc cat gtg cga ctt cag atg     1896
 Phe Ile Glu Gly Ser Ser Leu Gly Glu Phe His Val Arg Leu Gln Met
 575                 580                 585                 590

 tta ctg gtt ttc cat tgt cat gtc ttg ctg atg cca cag gtt gaa gga     1944
 Leu Leu Val Phe His Cys His Val Leu Leu Met Pro Gln Val Glu Gly
                 595                 600                 605

 aag gat tca ctt tgc agt gtt cta tgg aat ttg tac cat tat tac aag     1992
 Lys Asp Ser Leu Cys Ser Val Leu Trp Asn Leu Tyr His Tyr Tyr Lys
             610                 615                 620

 caa ttc ttt gac cgg gtc cag gcc aaa att gtg gaa ctt cgt tcc ccc     2040
 Gln Phe Phe Asp Arg Val Gln Ala Lys Ile Val Glu Leu Arg Ser Pro
         625                 630                 635

 cta gaa aaa gaa ctt aaa gaa ttt gtt aag att tcc aag tgg aat gat     2088
 Leu Glu Lys Glu Leu Lys Glu Phe Val Lys Ile Ser Lys Trp Asn Asp
     640                 645                 650

 gtc agc ttc tgg tcc att aag caa tct gta gaa aag aca cac agg aca     2136
 Val Ser Phe Trp Ser Ile Lys Gln Ser Val Glu Lys Thr His Arg Thr
 655                 660                 665                 670

 ctc ttt aaa ttc atg aag aaa ttt gaa gca gtc ctg agt gaa ccc tgc     2184
 Leu Phe Lys Phe Met Lys Lys Phe Glu Ala Val Leu Ser Glu Pro Cys
                 675                 680                 685

 cgg tca tcc ctg gtg gag agt gac aag gaa gaa cag cct gac ttt ttg     2232
 Arg Ser Ser Leu Val Glu Ser Asp Lys Glu Glu Gln Pro Asp Phe Leu
             690                 695                 700

 ccc agg cca aca gat gga gct gca agt gaa ctg tct tcc att cag aat     2280
 Pro Arg Pro Thr Asp Gly Ala Ala Ser Glu Leu Ser Ser Ile Gln Asn
         705                 710                 715

 ctg aac agg gca ctg agg gag acc ctg tta gcc caa cca gca gct ggg     2328
 Leu Asn Arg Ala Leu Arg Glu Thr Leu Leu Ala Gln Pro Ala Ala Gly
     720                 725                 730

 cag gcc aca att cca gag tgg tgt cag ggc gct gct cct tcc ggc ttg     2376
 Gln Ala Thr Ile Pro Glu Trp Cys Gln Gly Ala Ala Pro Ser Gly Leu
 735                 740                 745                 750

 gaa ggg gag ctt ctg cgt cgc ttg cca aag ctc agg aaa cgc atg agg     2424
 Glu Gly Glu Leu Leu Arg Arg Leu Pro Lys Leu Arg Lys Arg Met Arg
                 755                 760                 765

 aag atg tgc ctg acg ttc atg aag gag agc ccc ctg cct cgc ctt gtg     2472
 Lys Met Cys Leu Thr Phe Met Lys Glu Ser Pro Leu Pro Arg Leu Val
             770                 775                 780

 gag ggc ctt gat cag ttc aca ggt gaa gtg att tcc tct gtg agt gag     2520
 Glu Gly Leu Asp Gln Phe Thr Gly Glu Val Ile Ser Ser Val Ser Glu
         785                 790                 795

 ctg cag agc tta aag gtg gaa ccc tct gca gag aag gag aag cag cgg     2568
 Leu Gln Ser Leu Lys Val Glu Pro Ser Ala Glu Lys Glu Lys Gln Arg
     800                 805                 810

 tca gaa gcc aag cac att ctc atg caa aaa cag cga gct ttg tca gac     2616
 Ser Glu Ala Lys His Ile Leu Met Gln Lys Gln Arg Ala Leu Ser Asp
 815                 820                 825                 830

 ctc ttt aaa cac ctt gca aaa att ggt ttg tcg tat cgc aaa ggt ctt     2664
 Leu Phe Lys His Leu Ala Lys Ile Gly Leu Ser Tyr Arg Lys Gly Leu
                 835                 840                 845

 gct tgg gcc cgt tca aaa aac cct caa gag atg ctt cat ctt cac cca     2712
 Ala Trp Ala Arg Ser Lys Asn Pro Gln Glu Met Leu His Leu His Pro
             850                 855                 860

 tta gat ctc cag agc gca ttg tcc atc gtc agc agc act cag gag gct     2760
 Leu Asp Leu Gln Ser Ala Leu Ser Ile Val Ser Ser Thr Gln Glu Ala
         865                 870                 875

 gat tct agg ctg ctt aca gaa atc tcg tct tca tgg gat gga tgc cag     2808
 Asp Ser Arg Leu Leu Thr Glu Ile Ser Ser Ser Trp Asp Gly Cys Gln
     880                 885                 890

 aag tat ttt tat cgc tct ctt gca cgg cat gcc agg ctt aac gca gca     2856
 Lys Tyr Phe Tyr Arg Ser Leu Ala Arg His Ala Arg Leu Asn Ala Ala
 895                 900                 905                 910

 cta gca act cct gcc aag gaa atg ggc atg ggc aac gtg gag agg tgc     2904
 Leu Ala Thr Pro Ala Lys Glu Met Gly Met Gly Asn Val Glu Arg Cys
                 915                 920                 925

 aga ggg ttc tca gca cat ttg atg aag atg ctc gtc cga cag cgg cgc     2952
 Arg Gly Phe Ser Ala His Leu Met Lys Met Leu Val Arg Gln Arg Arg
             930                 935                 940

 tcc ctg acc acg ctc agt gag cag tgg atc atc ctc agg aac ctc ctc     3000
 Ser Leu Thr Thr Leu Ser Glu Gln Trp Ile Ile Leu Arg Asn Leu Leu
         945                 950                 955

 agc tgt gtg caa gag att cac agc agg ctg atg ggg ccc cag gcc tac     3048
 Ser Cys Val Gln Glu Ile His Ser Arg Leu Met Gly Pro Gln Ala Tyr
     960                 965                 970

 ccc gtg gcc ttc ccc cct cag gat ggc gtg cag cag tgg aca gag cgc     3096
 Pro Val Ala Phe Pro Pro Gln Asp Gly Val Gln Gln Trp Thr Glu Arg
 975                 980                 985                 990

 ctg cag cac ctg gcc atg cag tgc cag atc ctg ctt gag cag ctc tcc     3144
 Leu Gln His Leu Ala Met Gln Cys Gln Ile Leu Leu Glu Gln Leu Ser
                 995                1000                1005

 tgg ctc ctc cag tgc tgc ccc agt gta ggg cca gct cca ggc cat ggc     3192
 Trp Leu Leu Gln Cys Cys Pro Ser Val Gly Pro Ala Pro Gly His Gly
            1010                1015                1020

 aat gtc cag gta ctg ggg cag cct cct ggc ccc tgc ctg gaa gga cca     3240
 Asn Val Gln Val Leu Gly Gln Pro Pro Gly Pro Cys Leu Glu Gly Pro
        1025                1030                1035

 gaa ctt agc aag gga caa ctt tgt gga gta gtg ctg gac cta att cct     3288
 Glu Leu Ser Lys Gly Gln Leu Cys Gly Val Val Leu Asp Leu Ile Pro
    1040                1045                1050

 tcc aat ctg agc tac cca tct cca ata cct gga agt cag ctg ccc tct     3336
 Ser Asn Leu Ser Tyr Pro Ser Pro Ile Pro Gly Ser Gln Leu Pro Ser
1055                1060                1065                1070

 ggt tgc cgg atg cgg aaa cag gat cac ctt tgg caa cag tca act acg     3384
 Gly Cys Arg Met Arg Lys Gln Asp His Leu Trp Gln Gln Ser Thr Thr
                1075                1080                1085

 aga tta aca gag atg cta aaa acc att aaa aca gtg aaa gct gac gtc     3432
 Arg Leu Thr Glu Met Leu Lys Thr Ile Lys Thr Val Lys Ala Asp Val
            1090                1095                1100

 gac aaa att aga cag cag tct tgt gag act ctc ttt cat tct tgg aaa     3480
 Asp Lys Ile Arg Gln Gln Ser Cys Glu Thr Leu Phe His Ser Trp Lys
        1105                1110                1115

 gat ttt gaa gtt tgc tct tct gcg ctg agt tgc ttg tcc cag gtg tca     3528
 Asp Phe Glu Val Cys Ser Ser Ala Leu Ser Cys Leu Ser Gln Val Ser
    1120                1125                1130

 gtt cat ttg cag ggc cta gag tcc ttg ttc att ctt cca ggg atg gag     3576
 Val His Leu Gln Gly Leu Glu Ser Leu Phe Ile Leu Pro Gly Met Glu
1135                1140                1145                1150

 gtt gag caa aga gac tca caa atg gca cta gtt gaa agt ctg gaa tat     3624
 Val Glu Gln Arg Asp Ser Gln Met Ala Leu Val Glu Ser Leu Glu Tyr
                1155                1160                1165

 gta aga gga gaa att agt aaa gcc atg gct gac ttt act acc tgg aag     3672
 Val Arg Gly Glu Ile Ser Lys Ala Met Ala Asp Phe Thr Thr Trp Lys
            1170                1175                1180

 acc cat ctg ctt act tca gat agc caa gga gga aat caa atg ttg gac     3720
 Thr His Leu Leu Thr Ser Asp Ser Gln Gly Gly Asn Gln Met Leu Asp
        1185                1190                1195

 gaa gga ttt gtg gaa gat ttt tca gag caa atg gaa att gcc atc cga     3768
 Glu Gly Phe Val Glu Asp Phe Ser Glu Gln Met Glu Ile Ala Ile Arg
    1200                1205                1210

 gcc atc ctc tgt gcc atc cag aac tta gaa gaa aga aag aat gaa aaa     3816
 Ala Ile Leu Cys Ala Ile Gln Asn Leu Glu Glu Arg Lys Asn Glu Lys
1215                1220                1225                1230

 gca gag gag aac act gac caa gca agc cca caa gaa gat tat gca ggc     3864
 Ala Glu Glu Asn Thr Asp Gln Ala Ser Pro Gln Glu Asp Tyr Ala Gly
                1235                1240                1245

 ttt gag aga ctg caa tca gga cat cta aca aaa ctc tta gag gat gac     3912
 Phe Glu Arg Leu Gln Ser Gly His Leu Thr Lys Leu Leu Glu Asp Asp
            1250                1255                1260

 ttc tgg gcc gat gtg agc act ttg cac gtg cag aaa ata att tct gcc     3960
 Phe Trp Ala Asp Val Ser Thr Leu His Val Gln Lys Ile Ile Ser Ala
        1265                1270                1275

 atc tcc gag ctg ttg gag agg ctg aaa tcg tac ggt gag gat ggc aca     4008
 Ile Ser Glu Leu Leu Glu Arg Leu Lys Ser Tyr Gly Glu Asp Gly Thr
    1280                1285                1290

 gca gca aag cac ctg ttc ttc agc caa tcc tgt tcc ttg ctg gtg cgc     4056
 Ala Ala Lys His Leu Phe Phe Ser Gln Ser Cys Ser Leu Leu Val Arg
1295                1300                1305                1310

 ctg gtg ccg gtc ctc tcc agc tac tca gac ctc gtc ctc ttc ttc ctg     4104
 Leu Val Pro Val Leu Ser Ser Tyr Ser Asp Leu Val Leu Phe Phe Leu
                1315                1320                1325

 acc atg tct tta gca act cac cgt agt act gca aag ctg ctc tct gtg     4152
 Thr Met Ser Leu Ala Thr His Arg Ser Thr Ala Lys Leu Leu Ser Val
            1330                1335                1340

 ctt gcc cag gtc ttt aca gag ctt gcc cag aag gga ttt tgc ttg ccc     4200
 Leu Ala Gln Val Phe Thr Glu Leu Ala Gln Lys Gly Phe Cys Leu Pro
        1345                1350                1355

 aaa gaa ttt atg gaa gat tca gct gga gag gga gca act gag ttc cat     4248
 Lys Glu Phe Met Glu Asp Ser Ala Gly Glu Gly Ala Thr Glu Phe His
    1360                1365                1370

 gac tat gag gga ggt gga att gga gaa ggc gag ggc atg aag gat gtg     4296
 Asp Tyr Glu Gly Gly Gly Ile Gly Glu Gly Glu Gly Met Lys Asp Val
1375                1380                1385                1390

 agt gac cag atc gga aat gaa gaa cag gtg gaa gat aca ttt cag aag     4344
 Ser Asp Gln Ile Gly Asn Glu Glu Gln Val Glu Asp Thr Phe Gln Lys
                1395                1400                1405

 ggt caa gaa aaa gac aaa gag gat cct gat tca aaa tct gat att aag     4392
 Gly Gln Glu Lys Asp Lys Glu Asp Pro Asp Ser Lys Ser Asp Ile Lys
            1410                1415                1420

 ggc gag gat aat gcc att gag atg tcg gaa gat ttt gat ggg aaa atg     4440
 Gly Glu Asp Asn Ala Ile Glu Met Ser Glu Asp Phe Asp Gly Lys Met
        1425                1430                1435

 cat gat ggg gag ctt gaa gaa caa gaa gag gat gat gag aaa tca gat     4488
 His Asp Gly Glu Leu Glu Glu Gln Glu Glu Asp Asp Glu Lys Ser Asp
    1440                1445                1450

 agt gag ggc gga gac ctg gat aaa cac atg ggc gat ctc aat ggt gag     4536
 Ser Glu Gly Gly Asp Leu Asp Lys His Met Gly Asp Leu Asn Gly Glu
1455                1460                1465                1470

 gaa gct gac aaa cta gat gag agg ctt tgg ggt gat gat gat gag gag     4584
 Glu Ala Asp Lys Leu Asp Glu Arg Leu Trp Gly Asp Asp Asp Glu Glu
                1475                1480                1485

 gaa gat gag gag gaa gaa gac aat aaa act gaa gaa aca gga cca gga     4632
 Glu Asp Glu Glu Glu Glu Asp Asn Lys Thr Glu Glu Thr Gly Pro Gly
            1490                1495                1500

 atg gat gag gaa gat tct gaa ctt gtt gct aaa gat gac aac ttg gat     4680
 Met Asp Glu Glu Asp Ser Glu Leu Val Ala Lys Asp Asp Asn Leu Asp
        1505                1510                1515

 agt ggc aat tca aac aaa gat aaa agc cag caa gat aag aag gaa gaa     4728
 Ser Gly Asn Ser Asn Lys Asp Lys Ser Gln Gln Asp Lys Lys Glu Glu
    1520                1525                1530

 aag gaa gaa gca gaa gct gat gat ggt gga caa ggt gaa gac aaa att     4776
 Lys Glu Glu Ala Glu Ala Asp Asp Gly Gly Gln Gly Glu Asp Lys Ile
1535                1540                1545                1550

 aat gaa caa ata gat gag agg gac tat gat gaa aat gag gtg gac cct     4824
 Asn Glu Gln Ile Asp Glu Arg Asp Tyr Asp Glu Asn Glu Val Asp Pro
                1555                1560                1565

 tac cat ggc aat cag gaa aag gtg cca gaa ccc gag gct ttg gac ctt     4872
 Tyr His Gly Asn Gln Glu Lys Val Pro Glu Pro Glu Ala Leu Asp Leu
            1570                1575                1580

 cca gat gac ttg aac ctc gac agt gaa gac aag aat ggt ggt gag gac     4920
 Pro Asp Asp Leu Asn Leu Asp Ser Glu Asp Lys Asn Gly Gly Glu Asp
        1585                1590                1595

 acc gac aat gaa gaa gga gaa gaa gag aat cct ttg gag ata aaa gaa     4968
 Thr Asp Asn Glu Glu Gly Glu Glu Glu Asn Pro Leu Glu Ile Lys Glu
    1600                1605                1610

 aaa cca gaa gaa gca ggt cat gaa gct gag gaa aga gga gag acc gag     5016
 Lys Pro Glu Glu Ala Gly His Glu Ala Glu Glu Arg Gly Glu Thr Glu
1615                1620                1625                1630

 acc gac cag aac gaa agt cag agt cca cag gag cct gag gaa ggc ccc     5064
 Thr Asp Gln Asn Glu Ser Gln Ser Pro Gln Glu Pro Glu Glu Gly Pro
                1635                1640                1645

 agt gaa gat gac aag gca gaa ggg gaa gag gaa atg gac aca gga gct     5112
 Ser Glu Asp Asp Lys Ala Glu Gly Glu Glu Glu Met Asp Thr Gly Ala
            1650                1655                1660

 gat gac caa gat gga gat gct gct cag cat cct gaa gaa cac tct gag     5160
 Asp Asp Gln Asp Gly Asp Ala Ala Gln His Pro Glu Glu His Ser Glu
        1665                1670                1675

 gag cag cag cag tct gtg gag gaa aaa gac aag gaa gcc gat gaa gaa     5208
 Glu Gln Gln Gln Ser Val Glu Glu Lys Asp Lys Glu Ala Asp Glu Glu
    1680                1685                1690

 ggt gga gag aat ggc cct gct gac caa ggt ttc cag ccc cag gag gaa     5256
 Gly Gly Glu Asn Gly Pro Ala Asp Gln Gly Phe Gln Pro Gln Glu Glu
1695                1700                1705                1710

 gaa gaa cgg gag gac tct gat aca gag gag cag gtg cca gag gct ttg     5304
 Glu Glu Arg Glu Asp Ser Asp Thr Glu Glu Gln Val Pro Glu Ala Leu
                1715                1720                1725

 gag agg aag gag cat gcc tcc tgt ggg cag act ggt gtg gag aac atg     5352
 Glu Arg Lys Glu His Ala Ser Cys Gly Gln Thr Gly Val Glu Asn Met
            1730                1735                1740

 cag aac aca cag gcc atg gag ctg gct ggg gcc gca cct gag aag gag     5400
 Gln Asn Thr Gln Ala Met Glu Leu Ala Gly Ala Ala Pro Glu Lys Glu
        1745                1750                1755

 cag ggg aaa gag gaa cac gga agt gga gct gca gat gca aac cag gca     5448
 Gln Gly Lys Glu Glu His Gly Ser Gly Ala Ala Asp Ala Asn Gln Ala
    1760                1765                1770

 gaa ggc cat gaa tcg aat ttc att gcc cag ttg gcc tcc cag aag cac     5496
 Glu Gly His Glu Ser Asn Phe Ile Ala Gln Leu Ala Ser Gln Lys His
1775                1780                1785                1790

 acc agg aaa aac aca cag agt ttt aag agg aaa cct ggg cag gct gac     5544
 Thr Arg Lys Asn Thr Gln Ser Phe Lys Arg Lys Pro Gly Gln Ala Asp
                1795                1800                1805

 aat gaa cgt tcc atg ggt gat cac aat gag cgt gtg cac aag agg ctg     5592
 Asn Glu Arg Ser Met Gly Asp His Asn Glu Arg Val His Lys Arg Leu
            1810                1815                1820

 agg act gtg gat acg gac agc cat gcc gag cag ggg cca gct cag cag     5640
 Arg Thr Val Asp Thr Asp Ser His Ala Glu Gln Gly Pro Ala Gln Gln
        1825                1830                1835

 ccc cag gcc cag gtg gag gat gca gat gca ttc gag cac att aaa caa     5688
 Pro Gln Ala Gln Val Glu Asp Ala Asp Ala Phe Glu His Ile Lys Gln
    1840                1845                1850

 ggc agt gac gca tac gat gca cag acc tat gat gtg gcc agc aaa gaa     5736
 Gly Ser Asp Ala Tyr Asp Ala Gln Thr Tyr Asp Val Ala Ser Lys Glu
1855                1860                1865                1870

 cag caa cag tct gca aaa gac tct ggc aaa gat cag gaa gag gag gag     5784
 Gln Gln Gln Ser Ala Lys Asp Ser Gly Lys Asp Gln Glu Glu Glu Glu
                1875                1880                1885

 ata gag gac acc ctt atg gac aca gag gag cag gag gag ttc aaa gca     5832
 Ile Glu Asp Thr Leu Met Asp Thr Glu Glu Gln Glu Glu Phe Lys Ala
            1890                1895                1900

 gca gac gtg gag cag ctg aag cca gag gaa atc aag tcg ggc acc aca     5880
 Ala Asp Val Glu Gln Leu Lys Pro Glu Glu Ile Lys Ser Gly Thr Thr
        1905                1910                1915

 gca ccc ttg ggc ttt gat gag atg gaa gtg gag atc caa act gtt aaa     5928
 Ala Pro Leu Gly Phe Asp Glu Met Glu Val Glu Ile Gln Thr Val Lys
    1920                1925                1930

 aca gag gaa gac caa gac ccc aga aca gac aaa gcc cat aag gag aca     5976
 Thr Glu Glu Asp Gln Asp Pro Arg Thr Asp Lys Ala His Lys Glu Thr
1935                1940                1945                1950

 gaa aat gag aaa cca gaa aga agc cga gag tct acc att cat aca gct     6024
 Glu Asn Glu Lys Pro Glu Arg Ser Arg Glu Ser Thr Ile His Thr Ala
                1955                1960                1965

 cat caa ttc ctc atg gac acg atc ttc cag ccc ttt tta aaa gat gtc     6072
 His Gln Phe Leu Met Asp Thr Ile Phe Gln Pro Phe Leu Lys Asp Val
            1970                1975                1980

 aat gag cta aga cag gag ctg gag aga cag ctg gaa atg tgg cag cca     6120
 Asn Glu Leu Arg Gln Glu Leu Glu Arg Gln Leu Glu Met Trp Gln Pro
        1985                1990                1995

 cgt gaa tct gga aac cca gag gag gag aag gtt gca gct gag atg tgg     6168
 Arg Glu Ser Gly Asn Pro Glu Glu Glu Lys Val Ala Ala Glu Met Trp
    2000                2005                2010

 cag agt tac ctg atc tta aca gcg cct ctt tca caa cgg tta tgt gaa     6216
 Gln Ser Tyr Leu Ile Leu Thr Ala Pro Leu Ser Gln Arg Leu Cys Glu
2015                2020                2025                2030

 gag ctt cgt ctc ata tta gag cct acc cag gca gcc aag ctg aaa gga     6264
 Glu Leu Arg Leu Ile Leu Glu Pro Thr Gln Ala Ala Lys Leu Lys Gly
                2035                2040                2045

 gac tat cga act ggg aaa cga cta aac ata cgg aaa gtc att cca tac     6312
 Asp Tyr Arg Thr Gly Lys Arg Leu Asn Ile Arg Lys Val Ile Pro Tyr
            2050                2055                2060

 att gct agt caa ttt cgg aaa gac aag att tgg ctt cga agg acc aag     6360
 Ile Ala Ser Gln Phe Arg Lys Asp Lys Ile Trp Leu Arg Arg Thr Lys
        2065                2070                2075

 ccc agt aaa cgc cag tat cag att tgt ttg gct atc gat gac tct tct     6408
 Pro Ser Lys Arg Gln Tyr Gln Ile Cys Leu Ala Ile Asp Asp Ser Ser
    2080                2085                2090

 agt atg gta gac aat cat acc aag cag ctt gca ttt gaa tct ttg gct     6456
 Ser Met Val Asp Asn His Thr Lys Gln Leu Ala Phe Glu Ser Leu Ala
2095                2100                2105                2110

 gtg att gga aat gct cta acc ctc ctg gaa gtg ggt cag att gca gtg     6504
 Val Ile Gly Asn Ala Leu Thr Leu Leu Glu Val Gly Gln Ile Ala Val
                2115                2120                2125

 tgt agt ttt gga gaa tct gta aag ctg tta cac cca ttt cat gag cag     6552
 Cys Ser Phe Gly Glu Ser Val Lys Leu Leu His Pro Phe His Glu Gln
            2130                2135                2140

 ttc agt gat tac tct ggg tcc cag att cta cgt ctc tgc aaa ttc caa     6600
 Phe Ser Asp Tyr Ser Gly Ser Gln Ile Leu Arg Leu Cys Lys Phe Gln
        2145                2150                2155

 caa aag aaa acc aag att gct cag ttt cta gag tct gtt gcc aac atg     6648
 Gln Lys Lys Thr Lys Ile Ala Gln Phe Leu Glu Ser Val Ala Asn Met
    2160                2165                2170

 ttt gca gct gct cag cag ctc tcg cag aac atc agt tca gaa act gca     6696
 Phe Ala Ala Ala Gln Gln Leu Ser Gln Asn Ile Ser Ser Glu Thr Ala
2175                2180                2185                2190

 caa ctc ctc ctg gta gtc tct gat ggg cga ggc ctt ttc ctt gag ggc     6744
 Gln Leu Leu Leu Val Val Ser Asp Gly Arg Gly Leu Phe Leu Glu Gly
                2195                2200                2205

 aaa gaa aga gtc ctg gca gca gtt cag gct gcc cgg aat gca aat atc     6792
 Lys Glu Arg Val Leu Ala Ala Val Gln Ala Ala Arg Asn Ala Asn Ile
            2210                2215                2220

 ttt gtc atc ttt gtt gta ttg gac aat ccc agt tca cgg gat tct atc     6840
 Phe Val Ile Phe Val Val Leu Asp Asn Pro Ser Ser Arg Asp Ser Ile
        2225                2230                2235

 ttg gac att aaa gta ccg ata ttt aaa gga cct gga gag atg cct gaa     6888
 Leu Asp Ile Lys Val Pro Ile Phe Lys Gly Pro Gly Glu Met Pro Glu
    2240                2245                2250

 atc cga tcc tac atg gaa gag ttc cca ttc cca tac tat atc att ctt     6936
 Ile Arg Ser Tyr Met Glu Glu Phe Pro Phe Pro Tyr Tyr Ile Ile Leu
2255                2260                2265                2270

 cga gat gta aac gca ctt cct gag aca ctc agc gat gcc ctc aga cag     6984
 Arg Asp Val Asn Ala Leu Pro Glu Thr Leu Ser Asp Ala Leu Arg Gln
                2275                2280                2285

 tgg ttt gag ttg gtg aca gcc tct gac cac cca tag aaca gaaagaagag     7034
 Trp Phe Glu Leu Val Thr Ala Ser Asp His Pro 
            2290                2295

 tccaaagtga gacttaactg tggtcagaag gtcacattgc ttacccaggt gctccctttt   7094

 ggacaactac aaaaaatttt attgtaatat ttttatttta caacgtgatc ttacagccta   7154

 cagaatgctc tctggctccc ggctttgcct gggctgaggt ttttatacca aacctggaag   7214

 cagcagcagg tgcctgaact cgtaactaga gaagagttat ccttcttccc tgccttggaa   7274

 gccctggcct gggaggaggt cataccccac cgttggagcc cagctgcctg ttttcttttg   7334

 caggggatct gggcacctgt gccttgagga gatgctgcca ggagcatggg actctgacag   7394

 tcctttgtat aaaggactaa agggagctgc ccttttgacc ctgttctaag ctctgccttg   7454

 ccaagcccat agtgtgtgcc caaaagctgt caagtggcca agacagctcg tttctggaga   7514

 gtatgagggt gtgttttctt attgtgaaag gaactacctt ctcttagagg gtaggaagaa   7574

 tgtggtgtgt gtgtgttctc ataaagcaac tggacattat aggtgcccag gtcatctata   7634

 aaaacgatcc ttgggctgtg taaaaatgaa gtggcttttc agtatcctct ttcacacttg   7694

 ctgcttcggg agactatgca atgatgggaa ggtgattgcc cctttatttc attcagtgcc   7754

 atggtccctg ttgttgtagt aatttatttg tttagttcat tttttttttt cttaacagtc   7814

 aaggggaaga gtgattcctc acactgcttt caagctggac tgagccagtc tcattctggg   7874

 aaagaaacgc tgtgtccaga actcagcagc tccatctatt ttttccagtc gaaagaaact   7934

 gatctttagg cagtttttac ttggccagaa agcagtgctg aatacttgaa actgtgtgct   7994

 ctgttctact taatgttctg tcagaatgtt cttttgtagg cagtatgtca tgatgtaatc   8054

 atctatctcc ttgtctgttt ccaagttaca ctgtgaagtc tgcgaccctt ttgaggtggt   8114

 catcaaagac acagattcct tgtttaacca agtgtcccaa agcatgtacc tgaagttata   8174

 tcatttttta ttctaaaaag ctatgcagct tatattctga aaactattaa aacatatacc   8234

 actgttgttg atgtaatttg tgactcttct taatggaaga tgacaggatt gtaaaaggta   8294

 tgctagggga ctgatcttct ctgctggatc agtcagtcag ctgttactag ttgatgctgt   8354

 gctaacatga tcccctccta cttccatgtt gctcttacta caaaggttat catttgcatt   8414

 tatgtccatg gtaggctgag ctataatatg ctggctttgc agcagaatga aaaggatgag   8474

 ttggtgtagc cttataagga ggcttataaa aataaattat cctccataaa tgaaaaaaaa   8534

 aaaa                                                                8538




      <210> 97
      <211> 2163
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1441)

      <400> 97
 ctagagggtt cttcttcctt ctacttctgc tgaagggtaa cttccgatat caacttcctc     60

 aaacctctga tgagctgctg ctgctcgact ctgaggtgca ttcttttttt gatgagaggc    120

 atctctaggt accatccctg acctggtcct c   atg ctg ccg agg ctg ttg ctg     172
                                      Met Leu Pro Arg Leu Leu Leu
                                        1               5

 ttg atc tgt gct cca ctc tgt gaa cct gcc gag ctg ttt ttg ata gcc      220
 Leu Ile Cys Ala Pro Leu Cys Glu Pro Ala Glu Leu Phe Leu Ile Ala
          10                  15                  20

 agc ccc tcc cat ccc aca gag ggg agc cca gtg acc ctg acg tgt aag      268
 Ser Pro Ser His Pro Thr Glu Gly Ser Pro Val Thr Leu Thr Cys Lys
      25                  30                  35

 atg ccc ttt cta cag agt tca gat gcc cag ttc cag ttc tgc ttt ttc      316
 Met Pro Phe Leu Gln Ser Ser Asp Ala Gln Phe Gln Phe Cys Phe Phe
  40                  45                  50                  55

 aga gac acc cgg gcc ttg ggc cca ggc tgg agc agc tcc ccc aag ctc      364
 Arg Asp Thr Arg Ala Leu Gly Pro Gly Trp Ser Ser Ser Pro Lys Leu
                  60                  65                  70

 cag atc gct gcc atg tgg aaa gaa gac aca ggg tca tac tgg tgc gag      412
 Gln Ile Ala Ala Met Trp Lys Glu Asp Thr Gly Ser Tyr Trp Cys Glu
              75                  80                  85

 gca cag aca atg gcg tcc aaa gtc ttg agg agc agg aga tcc cag ata      460
 Ala Gln Thr Met Ala Ser Lys Val Leu Arg Ser Arg Arg Ser Gln Ile
          90                  95                 100

 aat gtg cac agg gtc cct gtc gct gat gtg agc ttg gag act cag ccc      508
 Asn Val His Arg Val Pro Val Ala Asp Val Ser Leu Glu Thr Gln Pro
     105                 110                 115

 cca gga gga cag gtg atg gag gga gac agg ctg gtc ctc atc tgc tca      556
 Pro Gly Gly Gln Val Met Glu Gly Asp Arg Leu Val Leu Ile Cys Ser
 120                 125                 130                 135

 gtt gct atg ggc aca gga gac atc acc ttc ctt tgg tac aaa ggg gct      604
 Val Ala Met Gly Thr Gly Asp Ile Thr Phe Leu Trp Tyr Lys Gly Ala
                 140                 145                 150

 gta ggt tta aac ctt cag tca aag acc cag cgt tca ctg aca gca gag      652
 Val Gly Leu Asn Leu Gln Ser Lys Thr Gln Arg Ser Leu Thr Ala Glu
             155                 160                 165

 tat gag att cct tca gtg agg gag agt gat gct gag caa tat tac tgt      700
 Tyr Glu Ile Pro Ser Val Arg Glu Ser Asp Ala Glu Gln Tyr Tyr Cys
         170                 175                 180

 gta gct gaa aat ggc tat ggt ccc agc ccc agt ggg ctg gtg agc atc      748
 Val Ala Glu Asn Gly Tyr Gly Pro Ser Pro Ser Gly Leu Val Ser Ile
     185                 190                 195

 act gtc aga atc ccg gtg tct cgc cca atc ctc atg ctc agg gct ccc      796
 Thr Val Arg Ile Pro Val Ser Arg Pro Ile Leu Met Leu Arg Ala Pro
 200                 205                 210                 215

 agg gcc cag gct gca gtg gag gat gtg ctg gag ctt cac tgt gag gcc      844
 Arg Ala Gln Ala Ala Val Glu Asp Val Leu Glu Leu His Cys Glu Ala
                 220                 225                 230

 ctg aga ggc tct cct cca atc ctg tac tgg ttt tat cac gag gat atc      892
 Leu Arg Gly Ser Pro Pro Ile Leu Tyr Trp Phe Tyr His Glu Asp Ile
             235                 240                 245

 acc ctg ggg agc agg tcg gcc ccc tct gga gga gga gcc tcc ttc aac      940
 Thr Leu Gly Ser Arg Ser Ala Pro Ser Gly Gly Gly Ala Ser Phe Asn
         250                 255                 260

 ctt tcc ctg act gaa gaa cat tct gga aac tac tcc tgt gag gcc aac      988
 Leu Ser Leu Thr Glu Glu His Ser Gly Asn Tyr Ser Cys Glu Ala Asn
     265                 270                 275

 aat ggc ctg ggg gcc cag cgc agt gag gcg gtg aca ctc aac ttc aca     1036
 Asn Gly Leu Gly Ala Gln Arg Ser Glu Ala Val Thr Leu Asn Phe Thr
 280                 285                 290                 295

 gtg cct act ggg gcc aga agc aat cat ctt acc tca gga gtc att gag     1084
 Val Pro Thr Gly Ala Arg Ser Asn His Leu Thr Ser Gly Val Ile Glu
                 300                 305                 310

 ggg ctg ctc agc acc ctt ggt cca gcc acc gtg gcc tta tta ttt tgc     1132
 Gly Leu Leu Ser Thr Leu Gly Pro Ala Thr Val Ala Leu Leu Phe Cys
             315                 320                 325

 tac ggc ctc aaa aga aaa ata gga aga cgt tca gcc agg gat cca ctc     1180
 Tyr Gly Leu Lys Arg Lys Ile Gly Arg Arg Ser Ala Arg Asp Pro Leu
         330                 335                 340

 agg agc ctt ccc agc cct cta ccc caa gag ttc acc tac ctc aac tca     1228
 Arg Ser Leu Pro Ser Pro Leu Pro Gln Glu Phe Thr Tyr Leu Asn Ser
     345                 350                 355

 cct acc cca ggg cag cta cag cct ata tat gaa aat gtg aat gtt gta     1276
 Pro Thr Pro Gly Gln Leu Gln Pro Ile Tyr Glu Asn Val Asn Val Val
 360                 365                 370                 375

 agt ggg gat gag gtt tat tca ctg gcg tac tat aac cag ccg gag cag     1324
 Ser Gly Asp Glu Val Tyr Ser Leu Ala Tyr Tyr Asn Gln Pro Glu Gln
                 380                 385                 390

 gaa tca gta gca gca gaa acc ctg ggg aca cat atg gag gac aag gtt     1372
 Glu Ser Val Ala Ala Glu Thr Leu Gly Thr His Met Glu Asp Lys Val
             395                 400                 405

 tcc tta gac atc tat tcc agg ctg agg aaa gca aac att aca gat gtg     1420
 Ser Leu Asp Ile Tyr Ser Arg Leu Arg Lys Ala Asn Ile Thr Asp Val
         410                 415                 420

 gac tat gaa gat gct atg taa gg ttatggaaga ttctgctctt tgaaaaccat     1473
 Asp Tyr Glu Asp Ala Met 
     425

 ccatgacccc aagcctcagg cctgatatgt tcttcagaga tcctggggca ttagctttcc   1533

 agtatacctc ttctggatgc cattctccat ggcactattc cttcatctac tgtgaagtga   1593

 agttggcgca gccctgaaga aactacctag gagaactaat agacacagga gtgacaggga   1653

 ctttgttatc agaaccagat tcctgccggc tcctttgaaa acaggtcata ttgtgctctt   1713

 ctgtttacaa gaggaaacaa gatggaataa aagaaattgg gatcttgggt tggagggaca   1773

 gtgaagctta gagcacatga actcaaggtt agtgactctg caggacttca cagagagagc   1833

 tgtgcccatc attcagtcca agtgctttct ctgcccagac agcacagaac tccagccccg   1893

 ctacttacat ggatcatcga gtttccacct aaaatatgat tctatttatt ttgagtcact   1953

 gttaccaaat tagaactaaa acaaagttac ataaaaagtt attgtgactc cacttaattt   2013

 tagtgacgta tttttgtata tataggccaa cctataccac atccaaaatt atgtatctat   2073

 tacagcccct agaagcttta taaatacagt gtgtcttctt ttattcacaa aatttttgaa   2133

 atcgtggtaa tatggtttga aacctgtatc                                    2163




      <210> 98
      <211> 2142
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1420)

      <400> 98
 ctagagggtt cttcttcctt ctacttctgc tgaagggtaa cttccgatat caacttcctc     60

 aaacctctga tgagctgctg ctgctcgact ctgaggtgca ttcttttttt gatgagaggc    120

 atctctaggt accatccctg acctggtcct c   atg ctg ccg agg ctg ttg ctg     172
                                      Met Leu Pro Arg Leu Leu Leu
                                        1               5

 ttg atc tgt gag ctg ttt ttg ata gcc agc ccc tcc cat ccc aca gag      220
 Leu Ile Cys Glu Leu Phe Leu Ile Ala Ser Pro Ser His Pro Thr Glu
          10                  15                  20

 ggg agc cca gtg acc ctg acg tgt aag atg ccc ttt cta cag agt tca      268
 Gly Ser Pro Val Thr Leu Thr Cys Lys Met Pro Phe Leu Gln Ser Ser
      25                  30                  35

 gat gcc cag ttc cag ttc tgc ttt ttc aga gac acc cgg gcc ttg ggc      316
 Asp Ala Gln Phe Gln Phe Cys Phe Phe Arg Asp Thr Arg Ala Leu Gly
  40                  45                  50                  55

 cca ggc tgg agc agc tcc ccc aag ctc cag atc gct gcc atg tgg aaa      364
 Pro Gly Trp Ser Ser Ser Pro Lys Leu Gln Ile Ala Ala Met Trp Lys
                  60                  65                  70

 gaa gac aca ggg tca tac tgg tgc gag gca cag aca atg gcg tcc aaa      412
 Glu Asp Thr Gly Ser Tyr Trp Cys Glu Ala Gln Thr Met Ala Ser Lys
              75                  80                  85

 gtc ttg agg agc agg aga tcc cag ata aat gtg cac agg gtc cct gtc      460
 Val Leu Arg Ser Arg Arg Ser Gln Ile Asn Val His Arg Val Pro Val
          90                  95                 100

 gct gat gtg agc ttg gag act cag ccc cca gga gga cag gtg atg gag      508
 Ala Asp Val Ser Leu Glu Thr Gln Pro Pro Gly Gly Gln Val Met Glu
     105                 110                 115

 gga gac agg ctg gtc ctc atc tgc tca gtt gct atg ggc aca gga gac      556
 Gly Asp Arg Leu Val Leu Ile Cys Ser Val Ala Met Gly Thr Gly Asp
 120                 125                 130                 135

 atc acc ttc ctt tgg tac aaa ggg gct gta ggt tta aac ctt cag tca      604
 Ile Thr Phe Leu Trp Tyr Lys Gly Ala Val Gly Leu Asn Leu Gln Ser
                 140                 145                 150

 aag acc cag cgt tca ctg aca gca gag tat gag att cct tca gtg agg      652
 Lys Thr Gln Arg Ser Leu Thr Ala Glu Tyr Glu Ile Pro Ser Val Arg
             155                 160                 165

 gag agt gat gct gag caa tat tac tgt gta gct gaa aat ggc tat ggt      700
 Glu Ser Asp Ala Glu Gln Tyr Tyr Cys Val Ala Glu Asn Gly Tyr Gly
         170                 175                 180

 ccc agc ccc agt ggg ctg gtg agc atc act gtc aga atc ccg gtg tct      748
 Pro Ser Pro Ser Gly Leu Val Ser Ile Thr Val Arg Ile Pro Val Ser
     185                 190                 195

 cgc cca atc ctc atg ctc agg gct ccc agg gcc cag gct gca gtg gag      796
 Arg Pro Ile Leu Met Leu Arg Ala Pro Arg Ala Gln Ala Ala Val Glu
 200                 205                 210                 215

 gat gtg ctg gag ctt cac tgt gag gcc ctg aga ggc tct cct cca atc      844
 Asp Val Leu Glu Leu His Cys Glu Ala Leu Arg Gly Ser Pro Pro Ile
                 220                 225                 230

 ctg tac tgg ttt tat cac gag gat atc acc ctg ggg agc agg tcg gcc      892
 Leu Tyr Trp Phe Tyr His Glu Asp Ile Thr Leu Gly Ser Arg Ser Ala
             235                 240                 245

 ccc tct gga gga gga gcc tcc ttc aac ctt tcc ctg act gaa gaa cat      940
 Pro Ser Gly Gly Gly Ala Ser Phe Asn Leu Ser Leu Thr Glu Glu His
         250                 255                 260

 tct gga aac tac tcc tgt gag gcc aac aat ggc ctg ggg gcc cag cgc      988
 Ser Gly Asn Tyr Ser Cys Glu Ala Asn Asn Gly Leu Gly Ala Gln Arg
     265                 270                 275

 agt gag gcg gtg aca ctc aac ttc aca gtg cct act ggg gcc aga agc     1036
 Ser Glu Ala Val Thr Leu Asn Phe Thr Val Pro Thr Gly Ala Arg Ser
 280                 285                 290                 295

 aat cat ctt acc tca gga gtc att gag ggg ctg ctc agc acc ctt ggt     1084
 Asn His Leu Thr Ser Gly Val Ile Glu Gly Leu Leu Ser Thr Leu Gly
                 300                 305                 310

 cca gcc acc gtg gcc tta tta ttt tgc tac ggc ctc aaa aga aaa ata     1132
 Pro Ala Thr Val Ala Leu Leu Phe Cys Tyr Gly Leu Lys Arg Lys Ile
             315                 320                 325

 gga aga cgt tca gcc agg gat cca ctc agg agc ctt ccc agc cct cta     1180
 Gly Arg Arg Ser Ala Arg Asp Pro Leu Arg Ser Leu Pro Ser Pro Leu
         330                 335                 340

 ccc caa gag ttc acc tac ctc aac tca cct acc cca ggg cag cta cag     1228
 Pro Gln Glu Phe Thr Tyr Leu Asn Ser Pro Thr Pro Gly Gln Leu Gln
     345                 350                 355

 cct ata tat gaa aat gtg aat gtt gta agt ggg gat gag gtt tat tca     1276
 Pro Ile Tyr Glu Asn Val Asn Val Val Ser Gly Asp Glu Val Tyr Ser
 360                 365                 370                 375

 ctg gcg tac tat aac cag ccg gag cag gaa tca gta gca gca gaa acc     1324
 Leu Ala Tyr Tyr Asn Gln Pro Glu Gln Glu Ser Val Ala Ala Glu Thr
                 380                 385                 390

 ctg ggg aca cat atg gag gac aag gtt tcc tta gac atc tat tcc agg     1372
 Leu Gly Thr His Met Glu Asp Lys Val Ser Leu Asp Ile Tyr Ser Arg
             395                 400                 405

 ctg agg aaa gca aac att aca gat gtg gac tat gaa gat gct atg taa     1420
 Leu Arg Lys Ala Asn Ile Thr Asp Val Asp Tyr Glu Asp Ala Met 
         410                 415                 420

 ggttatggaa gattctgctc tttgaaaacc atccatgacc ccaagcctca ggcctgatat   1480

 gttcttcaga gatcctgggg cattagcttt ccagtatacc tcttctggat gccattctcc   1540

 atggcactat tccttcatct actgtgaagt gaagttggcg cagccctgaa gaaactacct   1600

 aggagaacta atagacacag gagtgacagg gactttgtta tcagaaccag attcctgccg   1660

 gctcctttga aaacaggtca tattgtgctc ttctgtttac aagaggaaac aagatggaat   1720

 aaaagaaatt gggatcttgg gttggaggga cagtgaagct tagagcacat gaactcaagg   1780

 ttagtgactc tgcaggactt cacagagaga gctgtgccca tcattcagtc caagtgcttt   1840

 ctctgcccag acagcacaga actccagccc cgctacttac atggatcatc gagtttccac   1900

 ctaaaatatg attctattta ttttgagtca ctgttaccaa attagaacta aaacaaagtt   1960

 acataaaaag ttattgtgac tccacttaat tttagtgacg tatttttgta tatataggcc   2020

 aacctatacc acatccaaaa ttatgtatct attacagccc ctagaagctt tataaataca   2080

 gtgtgtcttc ttttattcac aaaatttttg aaatcgtggt aatatggttt gaaacctgta   2140

 tc                                                                  2142




      <210> 99
      <211> 4479
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (456)..(4448)

      <400> 99
 acggttcaaa taatgttgtc cacctttccc agaaactgga tattgggcta ttccctggcc     60

 aattgctccc tgatatcagg aaggagccag ggtggagctc cagcagcaaa ctgacccagg    120

 ctgttagagt ccgagttgca aatttcaaga gcgacaatct gactgggcca gtctggcctc    180

 tgggtcagtt ccccggggtc aggtctctgc aggatgatgt tcaaccatcg cagccaagga    240

 gcaacagagc cacgagaaca tcactctggc ttctccctgg gcagcagaag gaaggtggag    300

 aagacacctc caaaaggcat ctgtcacagg ttgaggccaa catccccatc agctctgagg    360

 ccgaacagtg cctccctaca tctacctgcc aagggcactg gcagggctta agttatgcag    420

 ccctgatagc cgactggccg gtggtggtct tgggc   atg tgc acc atg ttc atc     473
                                          Met Cys Thr Met Phe Ile
                                            1               5

 gta gtc tgt gcc ttg gtt gga gta tta gtg cca gag ctc cct gac ttc      521
 Val Val Cys Ala Leu Val Gly Val Leu Val Pro Glu Leu Pro Asp Phe
              10                  15                  20

 tct gat cca ttg ctg ggt ttt gaa cca aga gga aca gca ata ggc cag      569
 Ser Asp Pro Leu Leu Gly Phe Glu Pro Arg Gly Thr Ala Ile Gly Gln
          25                  30                  35

 aga ttg gtc aca tgg aat aat atg gtg aaa aat aca gga tac aaa gca      617
 Arg Leu Val Thr Trp Asn Asn Met Val Lys Asn Thr Gly Tyr Lys Ala
      40                  45                  50

 aca tta gca aat tat ccc ttt aaa tat gca gat gaa caa gcc aaa agc      665
 Thr Leu Ala Asn Tyr Pro Phe Lys Tyr Ala Asp Glu Gln Ala Lys Ser
  55                  60                  65                  70

 cat cgg gat gat aga tgg tca gat gat cat tat gaa aga gag aaa aga      713
 His Arg Asp Asp Arg Trp Ser Asp Asp His Tyr Glu Arg Glu Lys Arg
                  75                  80                  85

 gaa gtt gac tgg aac ttc cac aag gac agc ttt ttc tgc gac gtt cca      761
 Glu Val Asp Trp Asn Phe His Lys Asp Ser Phe Phe Cys Asp Val Pro
              90                  95                 100

 agt gac cga tat tcc aga gtg gta ttt act tca tct gga ggg gag aca      809
 Ser Asp Arg Tyr Ser Arg Val Val Phe Thr Ser Ser Gly Gly Glu Thr
         105                 110                 115

 tta tgg aat tta cct gca att aaa tca atg tgc aat gta gat aat tcc      857
 Leu Trp Asn Leu Pro Ala Ile Lys Ser Met Cys Asn Val Asp Asn Ser
     120                 125                 130

 agg atc aga tct cat ccc cag ttt ggt gat ctc tgc cag agg acc act      905
 Arg Ile Arg Ser His Pro Gln Phe Gly Asp Leu Cys Gln Arg Thr Thr
 135                 140                 145                 150

 gct gcc tcc tgc tgc ccc agc tgg aca ctg gga aac tac atc gcc att      953
 Ala Ala Ser Cys Cys Pro Ser Trp Thr Leu Gly Asn Tyr Ile Ala Ile
                 155                 160                 165

 ctg aac aat aga tcg tcc tgt cag aaa ata gtt gag cga gac gtt tct     1001
 Leu Asn Asn Arg Ser Ser Cys Gln Lys Ile Val Glu Arg Asp Val Ser
             170                 175                 180

 cat acc ttg aag ctg ctt cgg act tgt gcc aaa cac tac caa aat ggc     1049
 His Thr Leu Lys Leu Leu Arg Thr Cys Ala Lys His Tyr Gln Asn Gly
         185                 190                 195

 act ctg ggg cca gac tgc tgg gac atg gca gcc aga aga aag gac cag     1097
 Thr Leu Gly Pro Asp Cys Trp Asp Met Ala Ala Arg Arg Lys Asp Gln
     200                 205                 210

 ctc aag tgc acc aat gtg cca cgc aaa tgt acc aag tac aat gct gtg     1145
 Leu Lys Cys Thr Asn Val Pro Arg Lys Cys Thr Lys Tyr Asn Ala Val
 215                 220                 225                 230

 tac cag atc ctc cat tac ttg gtg gac aaa gac ttt atg acc cca aag     1193
 Tyr Gln Ile Leu His Tyr Leu Val Asp Lys Asp Phe Met Thr Pro Lys
                 235                 240                 245

 acg gct gac tat gcc acg cca gct tta aaa tac agc atg ctc ttc tct     1241
 Thr Ala Asp Tyr Ala Thr Pro Ala Leu Lys Tyr Ser Met Leu Phe Ser
             250                 255                 260

 ccc aca gag aaa ggg gag agc atg atg aac att tac ttg gac aac ttt     1289
 Pro Thr Glu Lys Gly Glu Ser Met Met Asn Ile Tyr Leu Asp Asn Phe
         265                 270                 275

 gaa aac tgg aac tct tct gac ggc gtg act acc atc acc ggg att gag     1337
 Glu Asn Trp Asn Ser Ser Asp Gly Val Thr Thr Ile Thr Gly Ile Glu
     280                 285                 290

 ttt ggt atc aaa cac agt ttg ttt cag gat tat ctt cta atg gat act     1385
 Phe Gly Ile Lys His Ser Leu Phe Gln Asp Tyr Leu Leu Met Asp Thr
 295                 300                 305                 310

 gtg tat cct gcc ata gcc att gtg att gtc ctt tta gtt atg tgt gtc     1433
 Val Tyr Pro Ala Ile Ala Ile Val Ile Val Leu Leu Val Met Cys Val
                 315                 320                 325

 tac acc aag tcc atg ttt atc act ctg atg aca atg ttt gca ata atc     1481
 Tyr Thr Lys Ser Met Phe Ile Thr Leu Met Thr Met Phe Ala Ile Ile
             330                 335                 340

 agt tct ttg att gtt tcc tat ttt ctc tat cgt gta gta ttt cac ttc     1529
 Ser Ser Leu Ile Val Ser Tyr Phe Leu Tyr Arg Val Val Phe His Phe
         345                 350                 355

 gaa ttt ttt cct ttt atg aac ctc act gcc ctc att att ttg gtt gga     1577
 Glu Phe Phe Pro Phe Met Asn Leu Thr Ala Leu Ile Ile Leu Val Gly
     360                 365                 370

 att gga gca gat gat gct ttt gtc ctg tgt gat gtt tgg aac tac aca     1625
 Ile Gly Ala Asp Asp Ala Phe Val Leu Cys Asp Val Trp Asn Tyr Thr
 375                 380                 385                 390

 aaa ttt gat aag cct cat gcc gaa acc tca gaa aca gta agc atc acc     1673
 Lys Phe Asp Lys Pro His Ala Glu Thr Ser Glu Thr Val Ser Ile Thr
                 395                 400                 405

 ttg cag cac gct gcc ctc tcc atg ttc gtc acc agt ttt acc act gct     1721
 Leu Gln His Ala Ala Leu Ser Met Phe Val Thr Ser Phe Thr Thr Ala
             410                 415                 420

 gct gcc ttt tat gct aac tat gtt agc aac att aca gca atc cga tgc     1769
 Ala Ala Phe Tyr Ala Asn Tyr Val Ser Asn Ile Thr Ala Ile Arg Cys
         425                 430                 435

 ttt ggg gtt tat gcg ggg aca gct ata ttg gtg aat tac gtt ttg atg     1817
 Phe Gly Val Tyr Ala Gly Thr Ala Ile Leu Val Asn Tyr Val Leu Met
     440                 445                 450

 gtc aca tgg ctt cca gca gtt gtt gtg ctg cat gag cgg tat ctt ctt     1865
 Val Thr Trp Leu Pro Ala Val Val Val Leu His Glu Arg Tyr Leu Leu
 455                 460                 465                 470

 aat ata ttc act tgc ttc aaa aag ccc cag cag caa ata tat gat aac     1913
 Asn Ile Phe Thr Cys Phe Lys Lys Pro Gln Gln Gln Ile Tyr Asp Asn
                 475                 480                 485

 aaa agc tgc tgg aca gtg gct tgc cag aag tgc cac aaa gta ctc ttt     1961
 Lys Ser Cys Trp Thr Val Ala Cys Gln Lys Cys His Lys Val Leu Phe
             490                 495                 500

 gcc att tca gaa gca tct cga att ttt ttc gaa aaa gta ttg cca tgc     2009
 Ala Ile Ser Glu Ala Ser Arg Ile Phe Phe Glu Lys Val Leu Pro Cys
         505                 510                 515

 att gtc att aag ttt cgc tac ctt tgg ctg ttt tgg ttc ctt gcc tta     2057
 Ile Val Ile Lys Phe Arg Tyr Leu Trp Leu Phe Trp Phe Leu Ala Leu
     520                 525                 530

 act gta ggt ggg gcc tac att gta tgt ata aat cca aag atg aaa ctg     2105
 Thr Val Gly Gly Ala Tyr Ile Val Cys Ile Asn Pro Lys Met Lys Leu
 535                 540                 545                 550

 ccc tca ctg gag tta tcc gag ttc cag gtg ttc cgg tcg tcc cat cct     2153
 Pro Ser Leu Glu Leu Ser Glu Phe Gln Val Phe Arg Ser Ser His Pro
                 555                 560                 565

 ttt gag cgt tat gat gct gaa tac aaa aag ctt ttc atg ttt gaa cgt     2201
 Phe Glu Arg Tyr Asp Ala Glu Tyr Lys Lys Leu Phe Met Phe Glu Arg
             570                 575                 580

 gtt cac cat ggc gag gag ctc cac atg ccc atc aca gta atc tgg ggc     2249
 Val His His Gly Glu Glu Leu His Met Pro Ile Thr Val Ile Trp Gly
         585                 590                 595

 gtg tcc cca gaa gac aat ggc aac cca cta aat ccc aag agt aaa ggg     2297
 Val Ser Pro Glu Asp Asn Gly Asn Pro Leu Asn Pro Lys Ser Lys Gly
     600                 605                 610

 aag ttg aca tta gat agc agt ttt aac atc gcc agc cca gct tcc cag     2345
 Lys Leu Thr Leu Asp Ser Ser Phe Asn Ile Ala Ser Pro Ala Ser Gln
 615                 620                 625                 630

 gcc tgg att ttg cac ttc tgt caa aaa ctg aga aac caa aca ttc ttt     2393
 Ala Trp Ile Leu His Phe Cys Gln Lys Leu Arg Asn Gln Thr Phe Phe
                 635                 640                 645

 tac cag act gat gaa cag gac ttc acc agc tgc ttc att gag aca ttc     2441
 Tyr Gln Thr Asp Glu Gln Asp Phe Thr Ser Cys Phe Ile Glu Thr Phe
             650                 655                 660

 aaa cag tgg atg gaa aac cag gac tgt gat gag cct gcc ctg tac cca     2489
 Lys Gln Trp Met Glu Asn Gln Asp Cys Asp Glu Pro Ala Leu Tyr Pro
         665                 670                 675

 tgc tgc agc cac tgg agc ttc ccc tac aag caa gag att ttt gaa ctg     2537
 Cys Cys Ser His Trp Ser Phe Pro Tyr Lys Gln Glu Ile Phe Glu Leu
     680                 685                 690

 tgc atc aag aga gct atc atg gag ctg gaa agg agt aca ggg tac cat     2585
 Cys Ile Lys Arg Ala Ile Met Glu Leu Glu Arg Ser Thr Gly Tyr His
 695                 700                 705                 710

 ttg gat agc aaa acc cca ggg ccg agg ttt gat atc aat gat act atc     2633
 Leu Asp Ser Lys Thr Pro Gly Pro Arg Phe Asp Ile Asn Asp Thr Ile
                 715                 720                 725

 agg gca gtg gtg tta gag ttc cag agt acc tac ctc ttc aca ctg gct     2681
 Arg Ala Val Val Leu Glu Phe Gln Ser Thr Tyr Leu Phe Thr Leu Ala
             730                 735                 740

 tat gaa aag atg cat cag ttt tat aaa gag gtg gac tcg tgg ata tcc     2729
 Tyr Glu Lys Met His Gln Phe Tyr Lys Glu Val Asp Ser Trp Ile Ser
         745                 750                 755

 agt gag ctg agt tcg gcc cct gaa ggc ctc agc aat ggt tgg ttt gtc     2777
 Ser Glu Leu Ser Ser Ala Pro Glu Gly Leu Ser Asn Gly Trp Phe Val
     760                 765                 770

 agc aat ctg gag ttc tat gac ctc cag gat agc ctc tcc gat ggc acc     2825
 Ser Asn Leu Glu Phe Tyr Asp Leu Gln Asp Ser Leu Ser Asp Gly Thr
 775                 780                 785                 790

 ctc att gcc atg ggg ctg tca gtt gct gtt gca ttt agc gtg atg ctg     2873
 Leu Ile Ala Met Gly Leu Ser Val Ala Val Ala Phe Ser Val Met Leu
                 795                 800                 805

 ctg aca act tgg aac atc atc ata agc ctt tat gcc atc att tca att     2921
 Leu Thr Thr Trp Asn Ile Ile Ile Ser Leu Tyr Ala Ile Ile Ser Ile
             810                 815                 820

 gct gga acg ata ttt gtc act gtt ggt tct ctt gtc ctg ctg ggc tgg     2969
 Ala Gly Thr Ile Phe Val Thr Val Gly Ser Leu Val Leu Leu Gly Trp
         825                 830                 835

 gag ctc aat gtg ttg gaa tct gtc acc att tcg gtt gcc gtc ggc ttg     3017
 Glu Leu Asn Val Leu Glu Ser Val Thr Ile Ser Val Ala Val Gly Leu
     840                 845                 850

 tct gta gac ttt gcc gtc cat tat ggg gtt gcc tac cgc ttg gct cca     3065
 Ser Val Asp Phe Ala Val His Tyr Gly Val Ala Tyr Arg Leu Ala Pro
 855                 860                 865                 870

 gat ccc gac cga gaa ggc aaa gtg atc ttc tct ctg agt cgc gtg ggc     3113
 Asp Pro Asp Arg Glu Gly Lys Val Ile Phe Ser Leu Ser Arg Val Gly
                 875                 880                 885

 tct gcg atg gcc atg gct gcc ctg acc acc ttc gtg gca ggg gcc atg     3161
 Ser Ala Met Ala Met Ala Ala Leu Thr Thr Phe Val Ala Gly Ala Met
             890                 895                 900

 atg atg ccc tcc aca gtt cta gct tac acc cag ctg ggc acc ttc atg     3209
 Met Met Pro Ser Thr Val Leu Ala Tyr Thr Gln Leu Gly Thr Phe Met
         905                 910                 915

 atg ctc atc atg tgt atc agt tgg gct ttc gcc acc ttc ttt ttc cag     3257
 Met Leu Ile Met Cys Ile Ser Trp Ala Phe Ala Thr Phe Phe Phe Gln
     920                 925                 930

 tgc atg tgc cgg tgc ctt gga cca cag ggt acc tgt ggt cag att cct     3305
 Cys Met Cys Arg Cys Leu Gly Pro Gln Gly Thr Cys Gly Gln Ile Pro
 935                 940                 945                 950

 tta cct aaa aaa cta cag tgc agt gcc ttt tcc cat gcc ttg tct aca     3353
 Leu Pro Lys Lys Leu Gln Cys Ser Ala Phe Ser His Ala Leu Ser Thr
                 955                 960                 965

 agt ccc agt gac aag gga caa agc aaa aca cat acc ata aat gct tat     3401
 Ser Pro Ser Asp Lys Gly Gln Ser Lys Thr His Thr Ile Asn Ala Tyr
             970                 975                 980

 cat tta gat ccc agg ggc cca aaa tct gaa ctg gag cat gag ttt tat     3449
 His Leu Asp Pro Arg Gly Pro Lys Ser Glu Leu Glu His Glu Phe Tyr
         985                 990                 995

 gaa tta gaa cct ctg gct tcc cac agc tgc act gcc cct gag aag acc     3497
 Glu Leu Glu Pro Leu Ala Ser His Ser Cys Thr Ala Pro Glu Lys Thr
    1000                1005                1010

 act tat gaa gag acc cac atc tgc tct gaa ttt ttc aac agc caa gca     3545
 Thr Tyr Glu Glu Thr His Ile Cys Ser Glu Phe Phe Asn Ser Gln Ala
1015                1020                1025                1030

 aag aat tta ggg atg cct gtg cat gca gct tac aac agt gaa ctc agc     3593
 Lys Asn Leu Gly Met Pro Val His Ala Ala Tyr Asn Ser Glu Leu Ser
                1035                1040                1045

 aaa agc act gaa agt gac gct ggc tct gcc ttg tta cag ccc cct ctt     3641
 Lys Ser Thr Glu Ser Asp Ala Gly Ser Ala Leu Leu Gln Pro Pro Leu
            1050                1055                1060

 gaa cag cat acc gtg tgt cac ttc ttc tct ctg aat cag aga tgt agc     3689
 Glu Gln His Thr Val Cys His Phe Phe Ser Leu Asn Gln Arg Cys Ser
        1065                1070                1075

 tgc cca gat gcc tac aaa cac ttg aac tat ggc cca cac tct tgc cag     3737
 Cys Pro Asp Ala Tyr Lys His Leu Asn Tyr Gly Pro His Ser Cys Gln
    1080                1085                1090

 cag atg ggg gac tgc ttg tgc cac cag tgc tct cct acc act agc agc     3785
 Gln Met Gly Asp Cys Leu Cys His Gln Cys Ser Pro Thr Thr Ser Ser
1095                1100                1105                1110

 ttt gtc cag atc caa aac ggc gtg gca cct ctg aag gcc aca cac caa     3833
 Phe Val Gln Ile Gln Asn Gly Val Ala Pro Leu Lys Ala Thr His Gln
                1115                1120                1125

 gct gtc gag ggc ttt gtg cac ccc atc acg cac atc cac cac tgt ccc     3881
 Ala Val Glu Gly Phe Val His Pro Ile Thr His Ile His His Cys Pro
            1130                1135                1140

 tgc ctg cag ggc aga gta aag cca gcc gga atg cag aat tct ctg cct     3929
 Cys Leu Gln Gly Arg Val Lys Pro Ala Gly Met Gln Asn Ser Leu Pro
        1145                1150                1155

 agg aat ttt ttc ctc cac cca gtg cag cac att cag gcc caa gaa aaa     3977
 Arg Asn Phe Phe Leu His Pro Val Gln His Ile Gln Ala Gln Glu Lys
    1160                1165                1170

 att ggc aag acc aat gta cac agt ctt cag agg agc ata gaa gag cat     4025
 Ile Gly Lys Thr Asn Val His Ser Leu Gln Arg Ser Ile Glu Glu His
1175                1180                1185                1190

 ctt cca aag atg gca gag cca tcg tca ttt gtc tgc aga agc act gga     4073
 Leu Pro Lys Met Ala Glu Pro Ser Ser Phe Val Cys Arg Ser Thr Gly
                1195                1200                1205

 tcg tta ctc aaa acg tgt tgc gac ccc gag aat aaa caa agg gaa ctc     4121
 Ser Leu Leu Lys Thr Cys Cys Asp Pro Glu Asn Lys Gln Arg Glu Leu
            1210                1215                1220

 tgt aaa aat aga gac gtg agc aat ctg gag agc agt gga ggg act gaa     4169
 Cys Lys Asn Arg Asp Val Ser Asn Leu Glu Ser Ser Gly Gly Thr Glu
        1225                1230                1235

 aac aag gca gga ggg aaa gtg gag ctg agc ttg tca cag acg gat gca     4217
 Asn Lys Ala Gly Gly Lys Val Glu Leu Ser Leu Ser Gln Thr Asp Ala
    1240                1245                1250

 agt gtg aac tca gaa cat ttc aat cag aat gaa cca aaa gtc cta ttt     4265
 Ser Val Asn Ser Glu His Phe Asn Gln Asn Glu Pro Lys Val Leu Phe
1255                1260                1265                1270

 aat cat tta atg ggg gag gct ggt tgt agg tct tgc cca aat aat tca     4313
 Asn His Leu Met Gly Glu Ala Gly Cys Arg Ser Cys Pro Asn Asn Ser
                1275                1280                1285

 caa agt tgt ggc aga att gtg aga gtg aag tgc aat tct gtg gac tgt     4361
 Gln Ser Cys Gly Arg Ile Val Arg Val Lys Cys Asn Ser Val Asp Cys
            1290                1295                1300

 caa atg cca aac atg gaa gcc aat gtg cct gct gta tta aca cac tcg     4409
 Gln Met Pro Asn Met Glu Ala Asn Val Pro Ala Val Leu Thr His Ser
        1305                1310                1315

 gaa ctt tct ggt gaa agt ttg tta ata aaa aca cta taa taaatgcagc      4458
 Glu Leu Ser Gly Glu Ser Leu Leu Ile Lys Thr Leu 
    1320                1325                1330

 attcaattca aaaaaaaaaa a                                             4479




      <210> 100
      <211> 1893
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(1623)

      <400> 100
 cttccctccc caggccacgg cagcccggcc ctcccgggca gacctcccgc accagggctc     60

 tggtgaacag caaatgctcc acgctgggac gggccattgc ctgatgcctg tacatggtgg    120

 gcactgagag acaagattcc tgggccctgc cttccataca ctccccacga tctcggagga    180

 agctctgggg accccgctga gaacccacag acaggaggac aactgcgcta tgacagcaat    240

 aaaggccaag aaggagaaag ttgaggaccg ctgacagccc cgtgtgctgt tgggagctgc    300

 cctttctact tcaaaccttc ctctagcaga ctgtgcaggg accccccacc accaccatct    360

 gccgcc   atg gtt gtg caa aac agc gca gat gcc ggg gac atg agg gca     408
          Met Val Val Gln Asn Ser Ala Asp Ala Gly Asp Met Arg Ala
            1               5                  10

 ggc gtg cag ctg gag ccc ttc ctg cac cag gtc ggg ggg cac atg agc      456
 Gly Val Gln Leu Glu Pro Phe Leu His Gln Val Gly Gly His Met Ser
  15                  20                  25                  30

 gtg atg aag tat gac gag cat acg gtg tgc aag ccc ctc gtc tcc cgg      504
 Val Met Lys Tyr Asp Glu His Thr Val Cys Lys Pro Leu Val Ser Arg
                  35                  40                  45

 gag cag agg ttc tat gaa tcc ctg ccg ctg gcc atg aag cgg ttc acc      552
 Glu Gln Arg Phe Tyr Glu Ser Leu Pro Leu Ala Met Lys Arg Phe Thr
              50                  55                  60

 cca cag tac aaa ggt acc gtc aca gtg cac ctc tgg aaa gac agc aca      600
 Pro Gln Tyr Lys Gly Thr Val Thr Val His Leu Trp Lys Asp Ser Thr
          65                  70                  75

 ggc cat ctc agc ttg gtt gcc aac cca gtg aag gag agc cag gag ccc      648
 Gly His Leu Ser Leu Val Ala Asn Pro Val Lys Glu Ser Gln Glu Pro
      80                  85                  90

 ttc aag gtc tcc aca gag tcg gcg gcg gtg gcc ata tgg cag acg ctc      696
 Phe Lys Val Ser Thr Glu Ser Ala Ala Val Ala Ile Trp Gln Thr Leu
  95                 100                 105                 110

 cag cag acc acc ggc agc aat ggc agc gac tgc acc ctt gcc cag tgg      744
 Gln Gln Thr Thr Gly Ser Asn Gly Ser Asp Cys Thr Leu Ala Gln Trp
                 115                 120                 125

 ccg cat gcc cag ctg gca cgc tca ccc aag gag agc ccg gcc aag gct      792
 Pro His Ala Gln Leu Ala Arg Ser Pro Lys Glu Ser Pro Ala Lys Ala
             130                 135                 140

 ctt ctg agg tcc gag ccc cac ctc aac act cca gcc ttc tcg ctg gtg      840
 Leu Leu Arg Ser Glu Pro His Leu Asn Thr Pro Ala Phe Ser Leu Val
         145                 150                 155

 gaa gac acc aac gga aac cag gtt gag agg aag agc ttc aac ccg tgg      888
 Glu Asp Thr Asn Gly Asn Gln Val Glu Arg Lys Ser Phe Asn Pro Trp
     160                 165                 170

 ggc ctg caa tgc cac cag gcc cac ctg acc cgc ctg tgc tcc gag tac      936
 Gly Leu Gln Cys His Gln Ala His Leu Thr Arg Leu Cys Ser Glu Tyr
 175                 180                 185                 190

 cca gag aac aag cgg cat cgt atc ctt gcc atc ccc ctc aca tgg ttc      984
 Pro Glu Asn Lys Arg His Arg Ile Leu Ala Ile Pro Leu Thr Trp Phe
                 195                 200                 205

 ttg ttg ctg gaa aat gta gtg tca cag tac acg cat ccc tgt gtc ctg     1032
 Leu Leu Leu Glu Asn Val Val Ser Gln Tyr Thr His Pro Cys Val Leu
             210                 215                 220

 gat ctg aag atg ggg acc cgg cag cac ggc gat gat gca tcg gag gag     1080
 Asp Leu Lys Met Gly Thr Arg Gln His Gly Asp Asp Ala Ser Glu Glu
         225                 230                 235

 aag aag gcc cgc cac atg agg aag tgt gcg cag agc acc tca gcc tgc     1128
 Lys Lys Ala Arg His Met Arg Lys Cys Ala Gln Ser Thr Ser Ala Cys
     240                 245                 250

 ctg ggt gtg cgc atc tgc ggc atg cag gtt tat caa aca gat aag aag     1176
 Leu Gly Val Arg Ile Cys Gly Met Gln Val Tyr Gln Thr Asp Lys Lys
 255                 260                 265                 270

 tac ttt ctc tgc aaa gac aag tac tat gga aga aaa ctc tca gtg gag     1224
 Tyr Phe Leu Cys Lys Asp Lys Tyr Tyr Gly Arg Lys Leu Ser Val Glu
                 275                 280                 285

 ggg ttc aga caa gcc ctc tat cag ttc cta cat aat gga agc cac ctc     1272
 Gly Phe Arg Gln Ala Leu Tyr Gln Phe Leu His Asn Gly Ser His Leu
             290                 295                 300

 cgg agg gag ctc ctg gag ccc atc ctg cac cag ctc cgg gcc ctc ctc     1320
 Arg Arg Glu Leu Leu Glu Pro Ile Leu His Gln Leu Arg Ala Leu Leu
         305                 310                 315

 tct gtc att agg agc cag agt tca tac cgc ttc tat tcc agc tct ctc     1368
 Ser Val Ile Arg Ser Gln Ser Ser Tyr Arg Phe Tyr Ser Ser Ser Leu
     320                 325                 330

 ctt gtc atc tat gat ggg cag gaa cca cca gaa aga gcc cca ggc agc     1416
 Leu Val Ile Tyr Asp Gly Gln Glu Pro Pro Glu Arg Ala Pro Gly Ser
 335                 340                 345                 350

 ccg cat cct cac gag gct ccc cag gca gcc cac ggt agc tct ccc ggt     1464
 Pro His Pro His Glu Ala Pro Gln Ala Ala His Gly Ser Ser Pro Gly
                 355                 360                 365

 ggt ctc acc aag gtt gac atc cgc atg att gac ttt gct cat acc aca     1512
 Gly Leu Thr Lys Val Asp Ile Arg Met Ile Asp Phe Ala His Thr Thr
             370                 375                 380

 tac aag ggc tac tgg aat gag cac acc acc tac gat gga cca gac cct     1560
 Tyr Lys Gly Tyr Trp Asn Glu His Thr Thr Tyr Asp Gly Pro Asp Pro
         385                 390                 395

 ggc tat att ttt ggc ctg gaa aac ctc atc agg atc ctg cag gat atc     1608
 Gly Tyr Ile Phe Gly Leu Glu Asn Leu Ile Arg Ile Leu Gln Asp Ile
     400                 405                 410

 caa gag gga gaa tga aacttcctgg gcttatctgg attcttctgg gctatagatc     1663
 Gln Glu Gly Glu 
 415

 tcaaatagag acctgttggt tgctagggta gtccagacac cccttagatg tcttcataat   1723

 agtcctatct accttcaaaa accatctcta tatatggcag actatattaa cagctgctga   1783

 acaaatcagc tctggaggtg attccacatc ccctggcatt atgctctaat gctgctcatc   1843

 ggagaacaga cagccaggat aaagtggcac cttctggagt acactgggag              1893




      <210> 101
      <211> 1863
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (367)..(1593)

      <400> 101
 cttccctccc caggccacgg cagcccggcc ctcccgggca gacctcccgc accagggctc     60

 tggtgaacag caaatgctcc acgctgggac gggccattgc ctgatgcctg tacatggtgg    120

 gcactgagag acaagattcc tgggccctgc cttccataca ctccccacga tctcggagga    180

 agctctgggg accccgctga gaacccacag acaggaggac aactgcgcta tgacagcaat    240

 aaaggccaag aaggagaaag ttgaggaccg ctgacagccc cgtgtgctgt tgggagctgc    300

 cctttctact tcaaaccttc ctctagcaga ctgtgcaggg accccccacc accaccatct    360

 gccgcc   atg gtt gtg caa aac agc gca gat gcc ggg gac atg agg gca     408
          Met Val Val Gln Asn Ser Ala Asp Ala Gly Asp Met Arg Ala
            1               5                  10

 ggc gtg cag ctg gag ccc ttc ctg cac cag gtc ggg ggg cac atg agc      456
 Gly Val Gln Leu Glu Pro Phe Leu His Gln Val Gly Gly His Met Ser
  15                  20                  25                  30

 gtg atg aag tat gac gag cat acg gtg tgc aag ccc ctc gtc tcc cgg      504
 Val Met Lys Tyr Asp Glu His Thr Val Cys Lys Pro Leu Val Ser Arg
                  35                  40                  45

 gag cag agg ttc tat gaa tcc ctg ccg ctg gcc atg aag cgg ttc acc      552
 Glu Gln Arg Phe Tyr Glu Ser Leu Pro Leu Ala Met Lys Arg Phe Thr
              50                  55                  60

 cca cag tac aaa ggt acc gtc aca gtg cac ctc tgg aaa gac agc aca      600
 Pro Gln Tyr Lys Gly Thr Val Thr Val His Leu Trp Lys Asp Ser Thr
          65                  70                  75

 ggc cat ctc agc ttg gtt gcc aac cca gtg aag gag agc cag gag ccc      648
 Gly His Leu Ser Leu Val Ala Asn Pro Val Lys Glu Ser Gln Glu Pro
      80                  85                  90

 ttc aag gtc tcc aca gag tcg gcg gcg gtg gcc ata tgg cag acg ctc      696
 Phe Lys Val Ser Thr Glu Ser Ala Ala Val Ala Ile Trp Gln Thr Leu
  95                 100                 105                 110

 cag cag acc acc ggc agc aat ggc agc gac tgc acc ctt gcc cag tgg      744
 Gln Gln Thr Thr Gly Ser Asn Gly Ser Asp Cys Thr Leu Ala Gln Trp
                 115                 120                 125

 ccg cat gcc cag ctg gca cgc tca ccc aag gag agc ccg gcc aag gct      792
 Pro His Ala Gln Leu Ala Arg Ser Pro Lys Glu Ser Pro Ala Lys Ala
             130                 135                 140

 ctt ctg agg tcc gag ccc cac ctc aac act cca gcc ttc tcg ctg gtg      840
 Leu Leu Arg Ser Glu Pro His Leu Asn Thr Pro Ala Phe Ser Leu Val
         145                 150                 155

 gaa gac acc aac gga aac cag gtt gag agg aag agc ttc aac ccg tgg      888
 Glu Asp Thr Asn Gly Asn Gln Val Glu Arg Lys Ser Phe Asn Pro Trp
     160                 165                 170

 ggc ctg caa tgc cac cag gcc cac ctg acc cgc ctg tgc tcc gag tac      936
 Gly Leu Gln Cys His Gln Ala His Leu Thr Arg Leu Cys Ser Glu Tyr
 175                 180                 185                 190

 cca gag aac aag cgg ttc ttg ttg ctg gaa aat gta gtg tca cag tac      984
 Pro Glu Asn Lys Arg Phe Leu Leu Leu Glu Asn Val Val Ser Gln Tyr
                 195                 200                 205

 acg cat ccc tgt gtc ctg gat ctg aag atg ggg acc cgg cag cac ggc     1032
 Thr His Pro Cys Val Leu Asp Leu Lys Met Gly Thr Arg Gln His Gly
             210                 215                 220

 gat gat gca tcg gag gag aag aag gcc cgc cac atg agg aag tgt gcg     1080
 Asp Asp Ala Ser Glu Glu Lys Lys Ala Arg His Met Arg Lys Cys Ala
         225                 230                 235

 cag agc acc tca gcc tgc ctg ggt gtg cgc atc tgc ggc atg cag gtt     1128
 Gln Ser Thr Ser Ala Cys Leu Gly Val Arg Ile Cys Gly Met Gln Val
     240                 245                 250

 tat caa aca gat aag aag tac ttt ctc tgc aaa gac aag tac tat gga     1176
 Tyr Gln Thr Asp Lys Lys Tyr Phe Leu Cys Lys Asp Lys Tyr Tyr Gly
 255                 260                 265                 270

 aga aaa ctc tca gtg gag ggg ttc aga caa gcc ctc tat cag ttc cta     1224
 Arg Lys Leu Ser Val Glu Gly Phe Arg Gln Ala Leu Tyr Gln Phe Leu
                 275                 280                 285

 cat aat gga agc cac ctc cgg agg gag ctc ctg gag ccc atc ctg cac     1272
 His Asn Gly Ser His Leu Arg Arg Glu Leu Leu Glu Pro Ile Leu His
             290                 295                 300

 cag ctc cgg gcc ctc ctc tct gtc att agg agc cag agt tca tac cgc     1320
 Gln Leu Arg Ala Leu Leu Ser Val Ile Arg Ser Gln Ser Ser Tyr Arg
         305                 310                 315

 ttc tat tcc agc tct ctc ctt gtc atc tat gat ggg cag gaa cca cca     1368
 Phe Tyr Ser Ser Ser Leu Leu Val Ile Tyr Asp Gly Gln Glu Pro Pro
     320                 325                 330

 gaa aga gcc cca ggc agc ccg cat cct cac gag gct ccc cag gca gcc     1416
 Glu Arg Ala Pro Gly Ser Pro His Pro His Glu Ala Pro Gln Ala Ala
 335                 340                 345                 350

 cac ggt agc tct ccc ggt ggt ctc acc aag gtt gac atc cgc atg att     1464
 His Gly Ser Ser Pro Gly Gly Leu Thr Lys Val Asp Ile Arg Met Ile
                 355                 360                 365

 gac ttt gct cat acc aca tac aag ggc tac tgg aat gag cac acc acc     1512
 Asp Phe Ala His Thr Thr Tyr Lys Gly Tyr Trp Asn Glu His Thr Thr
             370                 375                 380

 tac gat gga cca gac cct ggc tat att ttt ggc ctg gaa aac ctc atc     1560
 Tyr Asp Gly Pro Asp Pro Gly Tyr Ile Phe Gly Leu Glu Asn Leu Ile
         385                 390                 395

 agg atc ctg cag gat atc caa gag gga gaa tga aacttcct gggcttatct     1611
 Arg Ile Leu Gln Asp Ile Gln Glu Gly Glu 
     400                 405

 ggattcttct gggctataga tctcaaatag agacctgttg gttgctaggg tagtccagac   1671

 accccttaga tgtcttcata atagtcctat ctaccttcaa aaaccatctc tatatatggc   1731

 agactatatt aacagctgct gaacaaatca gctctggagg tgattccaca tcccctggca   1791

 ttatgctcta atgctgctca tcggagaaca gacagccagg ataaagtggc accttctgga   1851

 gtacactggg ag                                                       1863




      <210> 102
      <211> 3252
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (491)..(2506)

      <400> 102
 ccgactctgg tgatgtacga agggagaggc actgctgggc ctgccataca gctgcacagc     60

 ataagggacc gccctggcat ggccacagcc ttggtgacct ccttctccac atccagccag    120

 gggagagtct cagagagccc cagcctgctc tccgtgctgc tgccagaatt gttttcctac    180

 aacactctca ggaccaggga aacacagaaa gctgttttag gggagcatct ggcttctgct    240

 cctccaactc attctctgca gagcagcaag agtgaagtac ctgcgtgtgg agaaggaacc    300

 gcccgccccc tccccggctc tggacccggt tctgtgggag ggtccgttcc gggctcggtg    360

 cgactgcgca gctcctcggc gcttcctcgg tggcttcccc gggtcgagca aacaggtaag    420

 gtcggggaga cttcaggcca gggcagtctc ctgtcttctc ttggaaacca cagcagccca    480

 tgcacacaga   atg gca gcc aca ttc cag ctt cca ggg cac cag gag atg     529
              Met Ala Ala Thr Phe Gln Leu Pro Gly His Gln Glu Met
                1               5                  10

 ccg ctg acc ttc cag gat gtg gcc gtg tac ttc tct cag gcg gag ggg      577
 Pro Leu Thr Phe Gln Asp Val Ala Val Tyr Phe Ser Gln Ala Glu Gly
      15                  20                  25

 cgg cag ctg ggc ccc cag cag cgg gcg ctc tac cgg gat gtg atg ctg      625
 Arg Gln Leu Gly Pro Gln Gln Arg Ala Leu Tyr Arg Asp Val Met Leu
  30                  35                  40                  45

 gag aac tat ggg aac gtg gcc tct ctg gga ttc cct gtc cct aag ccg      673
 Glu Asn Tyr Gly Asn Val Ala Ser Leu Gly Phe Pro Val Pro Lys Pro
                  50                  55                  60

 gag ttg atc tcc cag ctg gag cag ggg aag gaa ctt tgg gtc ctg aat      721
 Glu Leu Ile Ser Gln Leu Glu Gln Gly Lys Glu Leu Trp Val Leu Asn
              65                  70                  75

 ctt ctg gga gct gag gaa cca gat atc ttg aaa agc tgc cag aaa gat      769
 Leu Leu Gly Ala Glu Glu Pro Asp Ile Leu Lys Ser Cys Gln Lys Asp
          80                  85                  90

 tct gag gtt ggg acc aag aag gaa cta tct att tta aac caa aaa ttt      817
 Ser Glu Val Gly Thr Lys Lys Glu Leu Ser Ile Leu Asn Gln Lys Phe
      95                 100                 105

 tcc gaa gaa gta aaa acc cca gaa ttt gta tca aga aga ctc tta agg      865
 Ser Glu Glu Val Lys Thr Pro Glu Phe Val Ser Arg Arg Leu Leu Arg
 110                 115                 120                 125

 gat aat gca cag gcc gct gag ttt cgg gaa gca tgg ggc cgt gag ggc      913
 Asp Asn Ala Gln Ala Ala Glu Phe Arg Glu Ala Trp Gly Arg Glu Gly
                 130                 135                 140

 aaa ctc aaa gag cgc gtg gga aat tct gcc ggg cag agt ttg aac aaa      961
 Lys Leu Lys Glu Arg Val Gly Asn Ser Ala Gly Gln Ser Leu Asn Lys
             145                 150                 155

 ccc aat att cac aag aga gtt tta aca gaa gct acc gtg ggc agg gaa     1009
 Pro Asn Ile His Lys Arg Val Leu Thr Glu Ala Thr Val Gly Arg Glu
         160                 165                 170

 aga tct ttg gga gaa aga acc caa gag tgt agt gca ttt gat aga aac     1057
 Arg Ser Leu Gly Glu Arg Thr Gln Glu Cys Ser Ala Phe Asp Arg Asn
     175                 180                 185

 ttg aat ctg gac caa aat gtt gtt aga ctt caa aga aat aaa aca gga     1105
 Leu Asn Leu Asp Gln Asn Val Val Arg Leu Gln Arg Asn Lys Thr Gly
 190                 195                 200                 205

 gag agg gtc ttt aaa tgt gat ata tgc agc aaa acc ttc aaa tat aat     1153
 Glu Arg Val Phe Lys Cys Asp Ile Cys Ser Lys Thr Phe Lys Tyr Asn
                 210                 215                 220

 tca gac cta agt aga cac cag aga agt cac act ggg gag aag ccg tac     1201
 Ser Asp Leu Ser Arg His Gln Arg Ser His Thr Gly Glu Lys Pro Tyr
             225                 230                 235

 gaa tgt ggc cgg tgt ggg cga gcc ttt act cac agc tca aat ctt gtt     1249
 Glu Cys Gly Arg Cys Gly Arg Ala Phe Thr His Ser Ser Asn Leu Val
         240                 245                 250

 ctg cac cat cac att cac act gga aat aaa cca ttt aaa tgt gat gaa     1297
 Leu His His His Ile His Thr Gly Asn Lys Pro Phe Lys Cys Asp Glu
     255                 260                 265

 tgt ggg aaa act ttt gga ctc aat tct cac ctc cgt ctt cat cgg aga     1345
 Cys Gly Lys Thr Phe Gly Leu Asn Ser His Leu Arg Leu His Arg Arg
 270                 275                 280                 285

 att cac act gga gaa aaa ccc ttt ggc tgt ggt gag tgt ggg aag gct     1393
 Ile His Thr Gly Glu Lys Pro Phe Gly Cys Gly Glu Cys Gly Lys Ala
                 290                 295                 300

 ttc agt cga agc tca act ctt att caa cat cgg atc att cac aca gga     1441
 Phe Ser Arg Ser Ser Thr Leu Ile Gln His Arg Ile Ile His Thr Gly
             305                 310                 315

 gag aaa ccc tac aag tgt aat gaa tgt gga aga ggc ttt agc cag agc     1489
 Glu Lys Pro Tyr Lys Cys Asn Glu Cys Gly Arg Gly Phe Ser Gln Ser
         320                 325                 330

 ccc cag tta act cag cat cag aga att cac act gga gag aag ccg cat     1537
 Pro Gln Leu Thr Gln His Gln Arg Ile His Thr Gly Glu Lys Pro His
     335                 340                 345

 gaa tgc agt cac tgt ggg aag gcc ttc agt cga agc tcc agc ctt att     1585
 Glu Cys Ser His Cys Gly Lys Ala Phe Ser Arg Ser Ser Ser Leu Ile
 350                 355                 360                 365

 cag cat gag aga att cac act gga gag aag ccc cat aaa tgc aat cag     1633
 Gln His Glu Arg Ile His Thr Gly Glu Lys Pro His Lys Cys Asn Gln
                 370                 375                 380

 tgt ggg aag gcc ttc agt cag agc tca agc ctt ttc ctc cat cat cgg     1681
 Cys Gly Lys Ala Phe Ser Gln Ser Ser Ser Leu Phe Leu His His Arg
             385                 390                 395

 gtt cat act gga gag aaa ccc tat gta tgt aat gaa tgc ggc aga gcc     1729
 Val His Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Arg Ala
         400                 405                 410

 ttt ggt ttt aac tct cat ctt act gaa cac gta agg att cac aca gga     1777
 Phe Gly Phe Asn Ser His Leu Thr Glu His Val Arg Ile His Thr Gly
     415                 420                 425

 gaa aaa ccc tat gtt tgt aat gag tgc ggc aaa gcc ttt cgt cgg agt     1825
 Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ala Phe Arg Arg Ser
 430                 435                 440                 445

 tcc act ctt gtt cag cat cga aga gtt cac act ggg gag aag ccc tac     1873
 Ser Thr Leu Val Gln His Arg Arg Val His Thr Gly Glu Lys Pro Tyr
                 450                 455                 460

 cag tgc gtt gaa tgt ggg aaa gct ttc agc cag agc tcc cag ctc acc     1921
 Gln Cys Val Glu Cys Gly Lys Ala Phe Ser Gln Ser Ser Gln Leu Thr
             465                 470                 475

 cta cat cag cga gtt cac act gga gag aag ccc tat gac tgt ggt gac     1969
 Leu His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Asp Cys Gly Asp
         480                 485                 490

 tgt ggg aag gcc ttc agc cgg agg tca acc ctc att cag cat cag aaa     2017
 Cys Gly Lys Ala Phe Ser Arg Arg Ser Thr Leu Ile Gln His Gln Lys
     495                 500                 505

 gtt cac agc gga gag act cgt aag tgc aga aaa cat ggt cca gcc ttt     2065
 Val His Ser Gly Glu Thr Arg Lys Cys Arg Lys His Gly Pro Ala Phe
 510                 515                 520                 525

 gtt cat ggc tcc agc ctc aca gca gat gga cag att ccc act gga gag     2113
 Val His Gly Ser Ser Leu Thr Ala Asp Gly Gln Ile Pro Thr Gly Glu
                 530                 535                 540

 aag cac ggc aga gcc ttt aac cat ggt gca aat ctc att ctg cgc tgg     2161
 Lys His Gly Arg Ala Phe Asn His Gly Ala Asn Leu Ile Leu Arg Trp
             545                 550                 555

 aca gtt cac act ggt gag aaa tcc ttt gga tgt aat gaa tat gga aaa     2209
 Thr Val His Thr Gly Glu Lys Ser Phe Gly Cys Asn Glu Tyr Gly Lys
         560                 565                 570

 gct ttc agt ccc acc tca cga ccc act gaa gat cag ata atg cat gct     2257
 Ala Phe Ser Pro Thr Ser Arg Pro Thr Glu Asp Gln Ile Met His Ala
     575                 580                 585

 ggg gaa aag ccc tat aaa tgt caa gaa tgt gga aac gcc ttc agt gga     2305
 Gly Glu Lys Pro Tyr Lys Cys Gln Glu Cys Gly Asn Ala Phe Ser Gly
 590                 595                 600                 605

 aag tca acc ctt att caa cat cag gta act cac act ggt cag aaa cca     2353
 Lys Ser Thr Leu Ile Gln His Gln Val Thr His Thr Gly Gln Lys Pro
                 610                 615                 620

 tgt cat tgc agt gtg tat ggg aaa gcc ttc agc cag agt tca cag ctc     2401
 Cys His Cys Ser Val Tyr Gly Lys Ala Phe Ser Gln Ser Ser Gln Leu
             625                 630                 635

 aca cca cct cag cag act cgt gtt gga gag aaa cct gct tta aat gat     2449
 Thr Pro Pro Gln Gln Thr Arg Val Gly Glu Lys Pro Ala Leu Asn Asp
         640                 645                 650

 ggc tct aaa aga tac ttt att cat atc aag aag att ttc caa gaa aga     2497
 Gly Ser Lys Arg Tyr Phe Ile His Ile Lys Lys Ile Phe Gln Glu Arg
     655                 660                 665

 cat ttt taa tgtgata aatgcagaag acagtttagc aactgttcac ttgacattag     2553
 His Phe 
 670

 aagataagat ggcataatga aagatatata aggtctaaat attactggca aagtaaaata   2613

 aatagttcag atgactacta aagtcaaagt cattaaatct ggaagtaaac acgagaattc   2673

 attctgggaa atcaggctgt ctgtgtaaag gttactgctg tgctcaggag ttgaaccgtg   2733

 tggtgctgta tccggatact catgacgaat ggatggaggg cgtgaaaagt gagcccagct   2793

 ggtgctctgg gtctacccta cctgacatcc ttccagtctt atcctttgtt tcctatccag   2853

 gcccaggctt gtggctgaga acatccactt tcagtcccat atacctgcct ccaagtgtgg   2913

 tacagagaac ttgggcctgc tgggggcgct tagccttact ctctccacca cctctcccac   2973

 caacccccag atgaactgca ggtagacgtt tcttccttgc ttggagcccc agtttttgca   3033

 tttcattttc attaaaatga aaggtggttt ggttttggtt ctaaggagct ctacagttta   3093

 acagagagag ggaccttagg ggccaagaaa gcaggggcct accaagtatc tccacttttg   3153

 aaaattgtaa ttactgataa aaaatttttt aaaggcaggt ttattgaagc ataatttata   3213

 aacaataaaa tttactcttt ttagtgtaaa aaaaaaaaa                          3252




      <210> 103
      <211> 2785
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (309)..(1826)

      <400> 103
 gcacgaggtt catgtctgcc atctggctcc aggattggga ttatccccgg gactctgacc     60

 gcgagttcta ccggcatctc ctggcgcacg ggtataggac gcggaggatg ctgagctgct    120

 gtcgcactgc agcacatcta cagatgtacg gatgccctcc tcttgatctt acagggtccg    180

 aggtacagcc gccagaaagg tctagtcagg aacagacaga gtcgcttgag gactcatgag    240

 ggggggtgct gcgctgacaa cagactacac cctcacagtt tgctctgctc ttcccacacc    300

 agtggaag atg atc aca tcc cag gga tca gtg tcg ttt agg gat gtg act     350
          Met Ile Thr Ser Gln Gly Ser Val Ser Phe Arg Asp Val Thr
            1               5                  10

 gtg ggc ttc act caa gag gag tgg cag cat ctg gac cct gct cag agg      398
 Val Gly Phe Thr Gln Glu Glu Trp Gln His Leu Asp Pro Ala Gln Arg
  15                  20                  25                  30

 acc ctg tac agg gat gtg atg ctg gag aac tac agc cac ctt gtc tca      446
 Thr Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Ser His Leu Val Ser
                  35                  40                  45

 gta ggg tat tgc att cct aaa cca gaa gtg att ctc aag ttg gag aaa      494
 Val Gly Tyr Cys Ile Pro Lys Pro Glu Val Ile Leu Lys Leu Glu Lys
              50                  55                  60

 ggc gag gag cca tgg ata tta gag gaa aaa ttt cca agc cag agt cat      542
 Gly Glu Glu Pro Trp Ile Leu Glu Glu Lys Phe Pro Ser Gln Ser His
          65                  70                  75

 ctg gaa tta att aat acc agt aga aac tat tca ata atg aag ttc aat      590
 Leu Glu Leu Ile Asn Thr Ser Arg Asn Tyr Ser Ile Met Lys Phe Asn
      80                  85                  90

 gag ttt aac aaa ggt gga aaa tgt ttc tgt gat gaa aag cat gaa ata      638
 Glu Phe Asn Lys Gly Gly Lys Cys Phe Cys Asp Glu Lys His Glu Ile
  95                 100                 105                 110

 att cat tct gaa gag gaa cct tct gaa tat aat aaa aat ggg aac agc      686
 Ile His Ser Glu Glu Glu Pro Ser Glu Tyr Asn Lys Asn Gly Asn Ser
                 115                 120                 125

 ttc tgg ctg aat gaa gac ctc att tgg cat cag aaa att aaa aat tgg      734
 Phe Trp Leu Asn Glu Asp Leu Ile Trp His Gln Lys Ile Lys Asn Trp
             130                 135                 140

 gaa caa tct ttt gaa tac aat gaa tgt ggg aaa gct ttc cct gag aat      782
 Glu Gln Ser Phe Glu Tyr Asn Glu Cys Gly Lys Ala Phe Pro Glu Asn
         145                 150                 155

 tca ctc ttc ctt gta cat aag aga ggt tac aca gga cag aaa acc tgc      830
 Ser Leu Phe Leu Val His Lys Arg Gly Tyr Thr Gly Gln Lys Thr Cys
     160                 165                 170

 aaa tat act gaa cat ggg aaa acc tgt gat atg tca ttt ttc atc act      878
 Lys Tyr Thr Glu His Gly Lys Thr Cys Asp Met Ser Phe Phe Ile Thr
 175                 180                 185                 190

 cat cag caa aca cat cca aga gaa aac cac tat ggt aat gaa tgt gga      926
 His Gln Gln Thr His Pro Arg Glu Asn His Tyr Gly Asn Glu Cys Gly
                 195                 200                 205

 gaa aat atc ttt gag gaa tcc att ctc ctt gaa cat cag agt gtt tac      974
 Glu Asn Ile Phe Glu Glu Ser Ile Leu Leu Glu His Gln Ser Val Tyr
             210                 215                 220

 cca ttc agc cag aag tta aat ctc act cca att cag aga acc cac tca     1022
 Pro Phe Ser Gln Lys Leu Asn Leu Thr Pro Ile Gln Arg Thr His Ser
         225                 230                 235

 att aac aat att att gaa tat aat gag tgt gga aca ttt ttc agt gaa     1070
 Ile Asn Asn Ile Ile Glu Tyr Asn Glu Cys Gly Thr Phe Phe Ser Glu
     240                 245                 250

 aaa tta gtc ctt cat tta caa cag aga aca cat aca gga gaa aaa cct     1118
 Lys Leu Val Leu His Leu Gln Gln Arg Thr His Thr Gly Glu Lys Pro
 255                 260                 265                 270

 tat gga tgt cat gaa tgt ggg aaa tcc ttc agt gaa aag tca acc ctt     1166
 Tyr Gly Cys His Glu Cys Gly Lys Ser Phe Ser Glu Lys Ser Thr Leu
                 275                 280                 285

 act caa cat caa aga acg cac aca ggg gag aaa cca tat gaa tgt cat     1214
 Thr Gln His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys His
             290                 295                 300

 gaa tgt ggg aaa acc ttc tca ttt aag tca gtc ctt act gtg cat cag     1262
 Glu Cys Gly Lys Thr Phe Ser Phe Lys Ser Val Leu Thr Val His Gln
         305                 310                 315

 aaa aca cac aca ggg gag aag ccc tat gaa tgc tat gca tgt ggg aaa     1310
 Lys Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Tyr Ala Cys Gly Lys
     320                 325                 330

 gcc ttt ctc aga aaa tca gac ctc att aaa cat caa aga ata cac aca     1358
 Ala Phe Leu Arg Lys Ser Asp Leu Ile Lys His Gln Arg Ile His Thr
 335                 340                 345                 350

 ggt gaa aaa cct tat gaa tgt aat gaa tgt ggg aag tca ttc tct gag     1406
 Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe Ser Glu
                 355                 360                 365

 aag tca acc ctt act aaa cat cta aga act cac aca ggt gag aaa cct     1454
 Lys Ser Thr Leu Thr Lys His Leu Arg Thr His Thr Gly Glu Lys Pro
             370                 375                 380

 tat gaa tgt att cag tgt gga aaa ttt ttc tgc tac tac tcc ggt ttc     1502
 Tyr Glu Cys Ile Gln Cys Gly Lys Phe Phe Cys Tyr Tyr Ser Gly Phe
         385                 390                 395

 aca gaa cat ctg aga aga cac aca ggg gag aaa cct ttt gga tgt aat     1550
 Thr Glu His Leu Arg Arg His Thr Gly Glu Lys Pro Phe Gly Cys Asn
     400                 405                 410

 gaa tgt ggg aaa acc ttc cgt cag aag tca gcc cta att gtt cac cag     1598
 Glu Cys Gly Lys Thr Phe Arg Gln Lys Ser Ala Leu Ile Val His Gln
 415                 420                 425                 430

 aga act cat ata aga cag aaa ccc tat gga tgt aat caa tgt gga aaa     1646
 Arg Thr His Ile Arg Gln Lys Pro Tyr Gly Cys Asn Gln Cys Gly Lys
                 435                 440                 445

 tca ttc tgt gtg aag tca aaa ctc att gca cat cat aga aca cac aca     1694
 Ser Phe Cys Val Lys Ser Lys Leu Ile Ala His His Arg Thr His Thr
             450                 455                 460

 ggg gag aaa ccc tat gaa tgt aat gtt tgt gga aaa tca ttc tat gtt     1742
 Gly Glu Lys Pro Tyr Glu Cys Asn Val Cys Gly Lys Ser Phe Tyr Val
         465                 470                 475

 aag tca aaa cta act gta cat cag aga ata cac ttg ggg aga aac cct     1790
 Lys Ser Lys Leu Thr Val His Gln Arg Ile His Leu Gly Arg Asn Pro
     480                 485                 490

 ata aat gta gta aac gag gga aat tac tct ggg tga agtc agaactttgt     1840
 Ile Asn Val Val Asn Glu Gly Asn Tyr Ser Gly 
 495                 500                 505

 agaacacaga acataaaggg tgagagaaat ctgttaatat aatgataatg agaacacctt   1900

 tgccctgaag tcagttctca cagtatagaa gagaacttaa agagggaaaa aacaatatga   1960

 agatagggaa tgcaggaaaa cattattctg gaatttggac catacactat gttacaaaac   2020

 taaaagtgga aaaaacttat tggtgaatga atataggaaa cattttgccc aatgccactc   2080

 ttcattaaac atcagagaat tcacacgggg tgaaacctgg gtcagcatcc ctaggttgag   2140

 aagggatgca tttttctgct actactacag tttcacagaa tacctgagaa gacacacttg   2200

 gagaaacctt ttgggtgtaa tgaatgtggg aaaacctttc atcagaagtc agctctaatt   2260

 gttcaccaca gaactcatat aagacagaaa ccctatgggt gtaatgaatg tggaaaatca   2320

 ttctgtgtga agtcaagagg ccagagaaaa tgcacaaact gtaggaaact ataggaaagc   2380

 atttactatg aggttatatt ttatggagta tatgtaataa gaagtagctt ctcagtgaac   2440

 atcagatagt agagaaagta tttttaactg tatccaatgt gtggatgttt taagttaaaa   2500

 tctaaattta atatagaaca gaggtgttga gttgcaggat atctagcaat ttaagaaaat   2560

 gtggaaaaaa tatttttatt gagaaatagc attttacttt gttaatatct agtttagttc   2620

 attgtcaaga ctgctatttt ctaagagact tctaaagacg ccactcaagc caatggctat   2680

 aagtagttca aaggtttatt gcttagccat atgaaaaata agggaagatt ttttagcaag   2740

 gggacccaca aacaagagtg ctcttgtatg tccaaaaaaa aaaaa                   2785




      <210> 104
      <211> 2440
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (629)..(2143)

      <400> 104
 gcgattccgg gcaggcagtg agtgatccgg gagttagggt caggctgggg gatgagaaac     60

 tacggcgact gtatctttgg ccgaggagtt ttaaatgcgc tggaagtgaa gggactgtgt    120

 cgtcaagggt agagacggga aaaaacgaga agtcctgagg aacatagatt cccctccccc    180

 gtacattttc ccggatggaa gcccgaagtt tgagggagaa acttgtgagg aaataaagga    240

 agttgggctg aggggcagag agcgagactt ttctattttc caaaagctcg gtctgaggcc    300

 cctcagtctt gcttcctacc ccgcgcttga gtttctcccc gcttggatgc tctcaggggc    360

 agtgtgaaga gagacagttc ctggcttcct tagagggcct tgttctcctt ggcagaagct    420

 caagtcctga ttcccgccct tccttctcgt tttaggaata ttgttctgag aagccacaga    480

 aaaagggtat gggcttattt tgccaaagaa aacacagcag ttgcaccctg ttttgcaaaa    540

 accatcagtg tttgggaatg attctgatga tgatgatgag acctctgtga gtgaaagcct    600

 tcagagggaa gctgctaaga agcaggcc   atg aaa cag acc aaa ctg gaa atc     652
                                  Met Lys Gln Thr Lys Leu Glu Ile
                                    1               5

 cag aag gcc ctt gca gaa gat gct act gtg tat gaa tat gac agt att      700
 Gln Lys Ala Leu Ala Glu Asp Ala Thr Val Tyr Glu Tyr Asp Ser Ile
      10                  15                  20

 tat gat gaa atg cag aaa aaa aag gag gaa aat aat ccc aaa ttg ctt      748
 Tyr Asp Glu Met Gln Lys Lys Lys Glu Glu Asn Asn Pro Lys Leu Leu
  25                  30                  35                  40

 ttg ggg aaa gac aga aag ccc aag tat att cac aac ttg cta aaa gca      796
 Leu Gly Lys Asp Arg Lys Pro Lys Tyr Ile His Asn Leu Leu Lys Ala
                  45                  50                  55

 gtt gag atc aga aaa aag gaa cag gaa aaa aga atg gaa aag aaa ata      844
 Val Glu Ile Arg Lys Lys Glu Gln Glu Lys Arg Met Glu Lys Lys Ile
              60                  65                  70

 cag aga gaa cga gaa atg gaa aag ggg gag ttt gat gat aaa gaa gca      892
 Gln Arg Glu Arg Glu Met Glu Lys Gly Glu Phe Asp Asp Lys Glu Ala
          75                  80                  85

 ttt gtg aca tct gca tat aag aaa aaa ctg caa gag aga gct gaa gaa      940
 Phe Val Thr Ser Ala Tyr Lys Lys Lys Leu Gln Glu Arg Ala Glu Glu
      90                  95                 100

 gaa gaa aga gaa aag agg gct gct gca ctg gaa gca tgt ttg gat gta      988
 Glu Glu Arg Glu Lys Arg Ala Ala Ala Leu Glu Ala Cys Leu Asp Val
 105                 110                 115                 120

 acc aag cag aaa gat ctc agt gga ttt tat agg cac cta tta aat caa     1036
 Thr Lys Gln Lys Asp Leu Ser Gly Phe Tyr Arg His Leu Leu Asn Gln
                 125                 130                 135

 gca gtt ggt gaa gag gaa gta cct aaa tgc agc ttt cgt gaa gcc aga     1084
 Ala Val Gly Glu Glu Glu Val Pro Lys Cys Ser Phe Arg Glu Ala Arg
             140                 145                 150

 tct ggt ata aag gaa gaa aaa tca agg ggc ttc tcc aat gaa gta agt     1132
 Ser Gly Ile Lys Glu Glu Lys Ser Arg Gly Phe Ser Asn Glu Val Ser
         155                 160                 165

 tca aaa aac aga ata cca caa gag aaa tgc att ctt caa act gat gtg     1180
 Ser Lys Asn Arg Ile Pro Gln Glu Lys Cys Ile Leu Gln Thr Asp Val
     170                 175                 180

 aaa gta gag gaa aac cca gat gca gac agt gac ttc gat gct aag agc     1228
 Lys Val Glu Glu Asn Pro Asp Ala Asp Ser Asp Phe Asp Ala Lys Ser
 185                 190                 195                 200

 agt gcg gat gat gaa ata gaa gaa act aga gtg aac tgc aga agg gaa     1276
 Ser Ala Asp Asp Glu Ile Glu Glu Thr Arg Val Asn Cys Arg Arg Glu
                 205                 210                 215

 aag gtc ata gag acc cct gag aat gac ttc aag cac cac agg agt caa     1324
 Lys Val Ile Glu Thr Pro Glu Asn Asp Phe Lys His His Arg Ser Gln
             220                 225                 230

 aac cac tct cgg tca cct agt gaa gaa aga ggg cac agt acc agg cac     1372
 Asn His Ser Arg Ser Pro Ser Glu Glu Arg Gly His Ser Thr Arg His
         235                 240                 245

 cac acg aaa gga tca cga acg tcg aga gga cat gag aaa agg gaa gat     1420
 His Thr Lys Gly Ser Arg Thr Ser Arg Gly His Glu Lys Arg Glu Asp
     250                 255                 260

 cag cac cag cag aag caa tcc aga gac caa gag aac cat tac act gac     1468
 Gln His Gln Gln Lys Gln Ser Arg Asp Gln Glu Asn His Tyr Thr Asp
 265                 270                 275                 280

 cgt gat tac cgg aaa gaa agg gat tct cat agg cac aga gag gcc agt     1516
 Arg Asp Tyr Arg Lys Glu Arg Asp Ser His Arg His Arg Glu Ala Ser
                 285                 290                 295

 cat aga gat tcc cat tgg aag agg cat gaa cag gaa gat aaa cca agg     1564
 His Arg Asp Ser His Trp Lys Arg His Glu Gln Glu Asp Lys Pro Arg
             300                 305                 310

 gcg agg gac caa aga gaa aga agt gac aga gta tgg aaa agg gag aaa     1612
 Ala Arg Asp Gln Arg Glu Arg Ser Asp Arg Val Trp Lys Arg Glu Lys
         315                 320                 325

 gat agg gag aaa tat tcc caa aga gaa caa gaa aga gat aga caa caa     1660
 Asp Arg Glu Lys Tyr Ser Gln Arg Glu Gln Glu Arg Asp Arg Gln Gln
     330                 335                 340

 aat gat cag aac cga ccc agt gag aaa gga gag aag gaa gag aaa agc     1708
 Asn Asp Gln Asn Arg Pro Ser Glu Lys Gly Glu Lys Glu Glu Lys Ser
 345                 350                 355                 360

 aaa gca aag gaa gag cat atg aaa gta agg aag gaa aga tat gaa aat     1756
 Lys Ala Lys Glu Glu His Met Lys Val Arg Lys Glu Arg Tyr Glu Asn
                 365                 370                 375

 aat gat aaa tac aga gat aga gaa aaa cga gag gta ggt gtt cag tct     1804
 Asn Asp Lys Tyr Arg Asp Arg Glu Lys Arg Glu Val Gly Val Gln Ser
             380                 385                 390

 tca gaa aga aat caa gac aga aag gaa agc agc cca aat tct agg gca     1852
 Ser Glu Arg Asn Gln Asp Arg Lys Glu Ser Ser Pro Asn Ser Arg Ala
         395                 400                 405

 aag gat aaa ttt ctt gac caa gaa aga tcc aac aaa atg aga aac atg     1900
 Lys Asp Lys Phe Leu Asp Gln Glu Arg Ser Asn Lys Met Arg Asn Met
     410                 415                 420

 gca aag gac aaa gaa aga aac caa gag aaa ccc tct aat tct gaa tca     1948
 Ala Lys Asp Lys Glu Arg Asn Gln Glu Lys Pro Ser Asn Ser Glu Ser
 425                 430                 435                 440

 tca ctg gga gca aaa cac aga ctc aca gag gaa ggg caa gag aag ggt     1996
 Ser Leu Gly Ala Lys His Arg Leu Thr Glu Glu Gly Gln Glu Lys Gly
                 445                 450                 455

 aaa gaa caa gag aga cca cct gag gca gtg agc aag ttt gca aag cgg     2044
 Lys Glu Gln Glu Arg Pro Pro Glu Ala Val Ser Lys Phe Ala Lys Arg
             460                 465                 470

 aac aat gaa gaa act gta atg tca gct aga gac agg tac ttg gcc agg     2092
 Asn Asn Glu Glu Thr Val Met Ser Ala Arg Asp Arg Tyr Leu Ala Arg
         475                 480                 485

 cag atg gcg cgg gtt aat gca aag acc tat att gag aaa gaa gat gat     2140
 Gln Met Ala Arg Val Asn Ala Lys Thr Tyr Ile Glu Lys Glu Asp Asp
     490                 495                 500

 tga tggc taccccaaga gaaagattta aggaagcaca gaaaactgta attcctggaa     2197
 


 cctgctgcgt aaaaccataa aggagtgtgt taccagtagt ttggagggca tttttaaatt   2257

 tattttcaaa attttaagtt aaaagtcagt cttacagctt ggatgtttgg atgtggatgt   2317

 ttggctgaat ttatatatag tgtgtactca tcaataccac attctttgtt gtattcaaga   2377

 accgttaaga gtgtgctaat tccctgtagg tacataatga ggaaaatttg ctccactaca   2437

 acc                                                                 2440




      <210> 105
      <211> 2072
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(1775)

      <400> 105
 gttcataaag cttatgacat gtcctgattt ggtagcttca tgtggaagag gtagtagatg     60

 tatttgctga catttaaaca taaaggttta agagcaag    atg gcg att ccg ggc     113
                                              Met Ala Ile Pro Gly
                                                1               5

 agg cag tat ggg ctt att ttg cca aag aaa aca cag cag ttg cac cct      161
 Arg Gln Tyr Gly Leu Ile Leu Pro Lys Lys Thr Gln Gln Leu His Pro
                  10                  15                  20

 gtt ttg caa aaa cca tca gtg ttt ggg aat gat tct gat gat gat gat      209
 Val Leu Gln Lys Pro Ser Val Phe Gly Asn Asp Ser Asp Asp Asp Asp
              25                  30                  35

 gag acc tct gtg agt gaa agc ctt cag agg gaa gct gct aag aag cag      257
 Glu Thr Ser Val Ser Glu Ser Leu Gln Arg Glu Ala Ala Lys Lys Gln
          40                  45                  50

 gcc atg aaa cag acc aaa ctg gaa atc cag aag gcc ctt gca gaa gat      305
 Ala Met Lys Gln Thr Lys Leu Glu Ile Gln Lys Ala Leu Ala Glu Asp
      55                  60                  65

 gct act gtg tat gaa tat gac agt att tat gat gaa atg cag aaa aaa      353
 Ala Thr Val Tyr Glu Tyr Asp Ser Ile Tyr Asp Glu Met Gln Lys Lys
  70                  75                  80                  85

 aag gag gaa aat aat ccc aaa ttg ctt ttg ggg aaa gac aga aag ccc      401
 Lys Glu Glu Asn Asn Pro Lys Leu Leu Leu Gly Lys Asp Arg Lys Pro
                  90                  95                 100

 aag tat att cac aac ttg cta aaa gca gtt gag atc aga aaa aag gaa      449
 Lys Tyr Ile His Asn Leu Leu Lys Ala Val Glu Ile Arg Lys Lys Glu
             105                 110                 115

 cag gaa aaa aga atg gaa aag aaa ata cag aga gaa cga gaa atg gaa      497
 Gln Glu Lys Arg Met Glu Lys Lys Ile Gln Arg Glu Arg Glu Met Glu
         120                 125                 130

 aag ggg gag ttt gat gat aaa gaa gca ttt gtg aca tct gca tat aag      545
 Lys Gly Glu Phe Asp Asp Lys Glu Ala Phe Val Thr Ser Ala Tyr Lys
     135                 140                 145

 aaa aaa ctg caa gag aga gct gaa gaa gaa gaa aga gaa aag agg gct      593
 Lys Lys Leu Gln Glu Arg Ala Glu Glu Glu Glu Arg Glu Lys Arg Ala
 150                 155                 160                 165

 gct gca ctg gaa gca tgt ttg gat gta acc aag cag aaa gat ctc agt      641
 Ala Ala Leu Glu Ala Cys Leu Asp Val Thr Lys Gln Lys Asp Leu Ser
                 170                 175                 180

 gga ttt tat agg cac cta tta aat caa gca gtt ggt gaa gag gaa gta      689
 Gly Phe Tyr Arg His Leu Leu Asn Gln Ala Val Gly Glu Glu Glu Val
             185                 190                 195

 cct aaa tgc agc ttt cgt gaa gcc aga tct ggt ata aag gaa gaa aaa      737
 Pro Lys Cys Ser Phe Arg Glu Ala Arg Ser Gly Ile Lys Glu Glu Lys
         200                 205                 210

 tca agg ggc ttc tcc aat gaa gta agt tca aaa aac aga ata cca caa      785
 Ser Arg Gly Phe Ser Asn Glu Val Ser Ser Lys Asn Arg Ile Pro Gln
     215                 220                 225

 gag aaa tgc att ctt caa act gat gtg aaa gta gag gaa aac cca gat      833
 Glu Lys Cys Ile Leu Gln Thr Asp Val Lys Val Glu Glu Asn Pro Asp
 230                 235                 240                 245

 gca gac agt gac ttc gat gct aag agc agt gcg gat gat gaa ata gaa      881
 Ala Asp Ser Asp Phe Asp Ala Lys Ser Ser Ala Asp Asp Glu Ile Glu
                 250                 255                 260

 gaa act aga gtg aac tgc aga agg gaa aag gtc ata gag acc cct gag      929
 Glu Thr Arg Val Asn Cys Arg Arg Glu Lys Val Ile Glu Thr Pro Glu
             265                 270                 275

 aat gac ttc aag cac cac agg agt caa aac cac tct cgg tca cct agt      977
 Asn Asp Phe Lys His His Arg Ser Gln Asn His Ser Arg Ser Pro Ser
         280                 285                 290

 gaa gaa aga ggg cac agt acc agg cac cac acg aaa gga tca cga acg     1025
 Glu Glu Arg Gly His Ser Thr Arg His His Thr Lys Gly Ser Arg Thr
     295                 300                 305

 tcg aga gga cat gag aaa agg gaa gat cag cac cag cag aag caa tcc     1073
 Ser Arg Gly His Glu Lys Arg Glu Asp Gln His Gln Gln Lys Gln Ser
 310                 315                 320                 325

 aga gac caa gag aac cat tac act gac cgt gat tac cgg aaa gaa agg     1121
 Arg Asp Gln Glu Asn His Tyr Thr Asp Arg Asp Tyr Arg Lys Glu Arg
                 330                 335                 340

 gat tct cat agg cac aga gag gcc agt cat aga gat tcc cat tgg aag     1169
 Asp Ser His Arg His Arg Glu Ala Ser His Arg Asp Ser His Trp Lys
             345                 350                 355

 agg cat gaa cag gaa gat aaa cca agg gcg agg gac caa aga gaa aga     1217
 Arg His Glu Gln Glu Asp Lys Pro Arg Ala Arg Asp Gln Arg Glu Arg
         360                 365                 370

 agt gac aga gta tgg aaa agg gag aaa gat agg gag aaa tat tcc caa     1265
 Ser Asp Arg Val Trp Lys Arg Glu Lys Asp Arg Glu Lys Tyr Ser Gln
     375                 380                 385

 aga gaa caa gaa aga gat aga caa caa aat gat cag aac cga ccc agt     1313
 Arg Glu Gln Glu Arg Asp Arg Gln Gln Asn Asp Gln Asn Arg Pro Ser
 390                 395                 400                 405

 gag aaa gga gag aag gaa gag aaa agc aaa gca aag gaa gag cat atg     1361
 Glu Lys Gly Glu Lys Glu Glu Lys Ser Lys Ala Lys Glu Glu His Met
                 410                 415                 420

 aaa gta agg aag gaa aga tat gaa aat aat gat aaa tac aga gat aga     1409
 Lys Val Arg Lys Glu Arg Tyr Glu Asn Asn Asp Lys Tyr Arg Asp Arg
             425                 430                 435

 gaa aaa cga gag gta ggt gtt cag tct tca gaa aga aat caa gac aga     1457
 Glu Lys Arg Glu Val Gly Val Gln Ser Ser Glu Arg Asn Gln Asp Arg
         440                 445                 450

 aag gaa agc agc cca aat tct agg gca aag gat aaa ttt ctt gac caa     1505
 Lys Glu Ser Ser Pro Asn Ser Arg Ala Lys Asp Lys Phe Leu Asp Gln
     455                 460                 465

 gaa aga tcc aac aaa atg aga aac atg gca aag gac aaa gaa aga aac     1553
 Glu Arg Ser Asn Lys Met Arg Asn Met Ala Lys Asp Lys Glu Arg Asn
 470                 475                 480                 485

 caa gag aaa ccc tct aat tct gaa tca tca ctg gga gca aaa cac aga     1601
 Gln Glu Lys Pro Ser Asn Ser Glu Ser Ser Leu Gly Ala Lys His Arg
                 490                 495                 500

 ctc aca gag gaa ggg caa gag aag ggt aaa gaa caa gag aga cca cct     1649
 Leu Thr Glu Glu Gly Gln Glu Lys Gly Lys Glu Gln Glu Arg Pro Pro
             505                 510                 515

 gag gca gtg agc aag ttt gca aag cgg aac aat gaa gaa act gta atg     1697
 Glu Ala Val Ser Lys Phe Ala Lys Arg Asn Asn Glu Glu Thr Val Met
         520                 525                 530

 tca gct aga gac agg tac ttg gcc agg cag atg gcg cgg gtt aat gca     1745
 Ser Ala Arg Asp Arg Tyr Leu Ala Arg Gln Met Ala Arg Val Asn Ala
     535                 540                 545

 aag acc tat att gag aaa gaa gat gat tga t ggctacccca agagaaagat     1796
 Lys Thr Tyr Ile Glu Lys Glu Asp Asp 
 550                 555

 ttaaggaagc acagaaaact gtaattcctg gaacctgctg cgtaaaacca taaaggagtg   1856

 tgttaccagt agtttggagg gcatttttaa atttattttc aaaattttaa gttaaaagtc   1916

 agtcttacag cttggatgtt tggatgtgga tgtttggctg aatttatata tagtgtgtac   1976

 tcatcaatac cacattcttt gttgtattca agaaccgtta agagtgtgct aattccctgt   2036

 aggtacataa tgaggaaaat ttgctccact acaacc                             2072




      <210> 106
      <211> 1679
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(1548)

      <400> 106
 aagcggctgt gcgcatgagc agatgaggcc tagccgaggc ggcgggaccc ccaagattgg     60

 aaagctcttt taacggctat gcgaaagctc tgtccaaagg ctgctcacag cccctgtctg    120

 actggatgtc atgatgaatt gagctctctg ttacctgcgc atcacaaccg agctgaggct    180

 tcgaagacct cagaggactt ctctcagcac tcacagaaac ctcctacacc ctcggatggc    240

 acaaagggac tgttttctta ctcttagtct gagtgactgc caaggaaggc aaaggtagag    300

 caactggatc tctggctctc cacatagctt ctgatctcag accttactaa aatgctttct    360

 gggcccaagg acaaagctca catgaacaaa tgattttgag tc   atg aat gaa aaa     414
                                                  Met Asn Glu Lys
                                                    1

 tct tgc tct ttc cat agt aaa gaa gaa tta aga gat gga cag ggt gaa      462
 Ser Cys Ser Phe His Ser Lys Glu Glu Leu Arg Asp Gly Gln Gly Glu
   5                  10                  15                  20

 aga ttg tct gct gga tat tct cca tca tat gac aag gac aag agt gtt      510
 Arg Leu Ser Ala Gly Tyr Ser Pro Ser Tyr Asp Lys Asp Lys Ser Val
                  25                  30                  35

 ctg gct ttc aga gga atc cct atc tca gag ttg aag aac cat ggc att      558
 Leu Ala Phe Arg Gly Ile Pro Ile Ser Glu Leu Lys Asn His Gly Ile
              40                  45                  50

 ctc cag gct ctg acc aca gaa gct tat gaa tgg gag cca cgt gtt gtg      606
 Leu Gln Ala Leu Thr Thr Glu Ala Tyr Glu Trp Glu Pro Arg Val Val
          55                  60                  65

 agt aca gag gtg gtc aga gcc caa gaa gaa tgg gaa gct gtg gac acc      654
 Ser Thr Glu Val Val Arg Ala Gln Glu Glu Trp Glu Ala Val Asp Thr
      70                  75                  80

 atc cag cca gag aca ggg agc caa gct agc tca gag cag cct ggg cag      702
 Ile Gln Pro Glu Thr Gly Ser Gln Ala Ser Ser Glu Gln Pro Gly Gln
  85                  90                  95                 100

 cta atc tcc ttc agt gag gcc ctg cag cac ttc cag act gtg gac ctt      750
 Leu Ile Ser Phe Ser Glu Ala Leu Gln His Phe Gln Thr Val Asp Leu
                 105                 110                 115

 tcc ccc ttc aag aaa aga atc cag cca act att cga agg act ggg ctc      798
 Ser Pro Phe Lys Lys Arg Ile Gln Pro Thr Ile Arg Arg Thr Gly Leu
             120                 125                 130

 gcc gcc ctc cga cac tac ctc ttc ggg cct cca aag ctc cac cag cgc      846
 Ala Ala Leu Arg His Tyr Leu Phe Gly Pro Pro Lys Leu His Gln Arg
         135                 140                 145

 ctt cgg gaa gaa agg gac ttg gtc ctg acc att gct cag tgt ggc ctg      894
 Leu Arg Glu Glu Arg Asp Leu Val Leu Thr Ile Ala Gln Cys Gly Leu
     150                 155                 160

 gat agc caa gac cca gtg cat ggc cga gtc ctc cag acc atc tat aag      942
 Asp Ser Gln Asp Pro Val His Gly Arg Val Leu Gln Thr Ile Tyr Lys
 165                 170                 175                 180

 aag ctg acc ggc tcc aag ttt gac tgt gcc ctt cat gga aac cac tgg      990
 Lys Leu Thr Gly Ser Lys Phe Asp Cys Ala Leu His Gly Asn His Trp
                 185                 190                 195

 gag gac ctg ggc ttt cag gga gcg aat cca gcc aca gac ctg aga ggc     1038
 Glu Asp Leu Gly Phe Gln Gly Ala Asn Pro Ala Thr Asp Leu Arg Gly
             200                 205                 210

 gca ggc ttc ctt gcc ctc ctg cat ctg ctc tac ctg gtg atg gac tca     1086
 Ala Gly Phe Leu Ala Leu Leu His Leu Leu Tyr Leu Val Met Asp Ser
         215                 220                 225

 aag acc ttg ccg atg gcg cag gag att ttc cgc ctg tct cgt cac cac     1134
 Lys Thr Leu Pro Met Ala Gln Glu Ile Phe Arg Leu Ser Arg His His
     230                 235                 240

 atc cag caa ttc cct ttc tgt ttg atg tcc gtg aac atc acc cac att     1182
 Ile Gln Gln Phe Pro Phe Cys Leu Met Ser Val Asn Ile Thr His Ile
 245                 250                 255                 260

 gcc atc cag gcc ttg aga gag gag tgt ctc tcc aga gag tgt aat cgg     1230
 Ala Ile Gln Ala Leu Arg Glu Glu Cys Leu Ser Arg Glu Cys Asn Arg
                 265                 270                 275

 cag cag aag gtc atc ccc gtg gtg aac agc ttc tat gcc gcc aca ttc     1278
 Gln Gln Lys Val Ile Pro Val Val Asn Ser Phe Tyr Ala Ala Thr Phe
             280                 285                 290

 ctc cac ctc gca cat gtc tgg agg aca cag cgg aag acc atc tca gac     1326
 Leu His Leu Ala His Val Trp Arg Thr Gln Arg Lys Thr Ile Ser Asp
         295                 300                 305

 tcg ggc ttt gtc ctc aaa gag ttg gaa gta ttg gcc aag aag agc cca     1374
 Ser Gly Phe Val Leu Lys Glu Leu Glu Val Leu Ala Lys Lys Ser Pro
     310                 315                 320

 cgg cgg ctg ctc aag acc ctg gag ctg tac ttg gcc agg gtg tca aag     1422
 Arg Arg Leu Leu Lys Thr Leu Glu Leu Tyr Leu Ala Arg Val Ser Lys
 325                 330                 335                 340

 gga cag gcc tcc ttg ttg gga gca cag aag tgc tat ggg cca gaa gcc     1470
 Gly Gln Ala Ser Leu Leu Gly Ala Gln Lys Cys Tyr Gly Pro Glu Ala
                 345                 350                 355

 cct ccc ttc aag gat ctc acc ttc aca ggt gag agt gac ctg cag tct     1518
 Pro Pro Phe Lys Asp Leu Thr Phe Thr Gly Glu Ser Asp Leu Gln Ser
             360                 365                 370

 cac tca tcc gaa ggc gta tgg ctg atc tga c ctccgagatg aatggaggct     1569
 His Ser Ser Glu Gly Val Trp Leu Ile 
         375                 380

 taaaggctga gctgcagggg ctttcagggg gtcagtggag ccatgtcagg agcctggcca   1629

 ggccgcaccc cttgctgtct cagcagatgg gatataggaa gctcctggcg              1679




      <210> 107
      <211> 6013
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (411)..(5348)

      <400> 107
 cgggccagga ccccattaca ggctctgtcc tctcccctcg ccccctcccc cggcaaccgc     60

 tctccctcgc cccctcccct cagcgggtcc tcctctttct ctccctctcc ctctccctcc    120

 tcctccctct ccccatccct tcccccccac aatgcagttc gcggcgcggc ggacatggcg    180

 gtggagtcct gagctagtcg tgtcccggcc tccagcggcg gcagcggcga cggcggcggc    240

 agcaggaggc ggagggagag caggagccac tgagatgagg aggcgtcgcg cgcgcctgta    300

 gctcgcgggc ctcgcagttt gcttgcctaa actggacttg aagcaattta aactactgga    360

 gatctgccat tttataatat cacaattgga aagaaacaga ttttcaaata   atg gaa     416
                                                          Met Glu
                                                            1

 gag tct aaa acc tta aaa agt gaa aat cat gaa cca aag aag aat gtt      464
 Glu Ser Lys Thr Leu Lys Ser Glu Asn His Glu Pro Lys Lys Asn Val
           5                  10                  15

 att tgt gaa gaa agc aaa gca gtt caa gtt ata ggt aat caa aca ttg      512
 Ile Cys Glu Glu Ser Lys Ala Val Gln Val Ile Gly Asn Gln Thr Leu
      20                  25                  30

 aaa gct aga aat gat aaa tcc gta aaa gaa att gag aac agc tct cca      560
 Lys Ala Arg Asn Asp Lys Ser Val Lys Glu Ile Glu Asn Ser Ser Pro
  35                  40                  45                  50

 aat agg aat agt agt aaa aaa aat aag caa aat gat att tgt ata gaa      608
 Asn Arg Asn Ser Ser Lys Lys Asn Lys Gln Asn Asp Ile Cys Ile Glu
                  55                  60                  65

 aaa aca gaa gtt aaa tca tgt aaa gta aat gct gcc aac ctt cca ggt      656
 Lys Thr Glu Val Lys Ser Cys Lys Val Asn Ala Ala Asn Leu Pro Gly
              70                  75                  80

 cct aaa gat ttg ggg tta gtc ctt cga gat caa agt cat tgc aaa gca      704
 Pro Lys Asp Leu Gly Leu Val Leu Arg Asp Gln Ser His Cys Lys Ala
          85                  90                  95

 aaa aaa ttt cct aat tca ccg gtg aaa gcc gaa aag gca acc att tca      752
 Lys Lys Phe Pro Asn Ser Pro Val Lys Ala Glu Lys Ala Thr Ile Ser
     100                 105                 110

 cag gca aaa tca gaa aag gca acc agt tta cag gca aaa gca gaa aaa      800
 Gln Ala Lys Ser Glu Lys Ala Thr Ser Leu Gln Ala Lys Ala Glu Lys
 115                 120                 125                 130

 tca cca aag tca cct aat tca gtg aaa gca gaa aaa gca tcc agt tat      848
 Ser Pro Lys Ser Pro Asn Ser Val Lys Ala Glu Lys Ala Ser Ser Tyr
                 135                 140                 145

 cag atg aag tca gaa aaa gta cca agt tca cca gca gaa gca gaa aag      896
 Gln Met Lys Ser Glu Lys Val Pro Ser Ser Pro Ala Glu Ala Glu Lys
             150                 155                 160

 gga ccc agt tta ctg ttg aaa gac atg aga cag aag aca gaa tta caa      944
 Gly Pro Ser Leu Leu Leu Lys Asp Met Arg Gln Lys Thr Glu Leu Gln
         165                 170                 175

 cag att gga aaa aaa att cca agc tcc ttt act tct gtg gac aaa gtg      992
 Gln Ile Gly Lys Lys Ile Pro Ser Ser Phe Thr Ser Val Asp Lys Val
     180                 185                 190

 aat att gaa gct gta ggg gga gaa aaa tgt gct ctg caa aac tca cca     1040
 Asn Ile Glu Ala Val Gly Gly Glu Lys Cys Ala Leu Gln Asn Ser Pro
 195                 200                 205                 210

 cga tct cag aag caa cag aca tgt aca gat aat act ggt gat tct gat     1088
 Arg Ser Gln Lys Gln Gln Thr Cys Thr Asp Asn Thr Gly Asp Ser Asp
                 215                 220                 225

 gat agt gct tca gga att gaa gac gta tcg gac gat tta agt aaa atg     1136
 Asp Ser Ala Ser Gly Ile Glu Asp Val Ser Asp Asp Leu Ser Lys Met
             230                 235                 240

 aag aat gat gaa tct aat aaa gaa aat tct tca gag atg gac tac tta     1184
 Lys Asn Asp Glu Ser Asn Lys Glu Asn Ser Ser Glu Met Asp Tyr Leu
         245                 250                 255

 gaa aat gcc act gtg ata gat gaa tct gca ttg aca cct gag cag agg     1232
 Glu Asn Ala Thr Val Ile Asp Glu Ser Ala Leu Thr Pro Glu Gln Arg
     260                 265                 270

 ctg ggg ttg aaa caa gca gaa gaa cgc tta gaa aga gat cac atc ttt     1280
 Leu Gly Leu Lys Gln Ala Glu Glu Arg Leu Glu Arg Asp His Ile Phe
 275                 280                 285                 290

 cga ctt gaa aaa cga tca cca gaa tat acc aat tgt cgg tat cta tgc     1328
 Arg Leu Glu Lys Arg Ser Pro Glu Tyr Thr Asn Cys Arg Tyr Leu Cys
                 295                 300                 305

 aaa ctt tgc tta att cac att gaa aat atc cag ggg gct cat aaa cat     1376
 Lys Leu Cys Leu Ile His Ile Glu Asn Ile Gln Gly Ala His Lys His
             310                 315                 320

 ata aag gag aaa cga cat aag aaa aat att ttg gaa aaa caa gaa gaa     1424
 Ile Lys Glu Lys Arg His Lys Lys Asn Ile Leu Glu Lys Gln Glu Glu
         325                 330                 335

 agt gag ctt cgt tct ctg cca cct cct tcc cct gcc cac ttg gct gct     1472
 Ser Glu Leu Arg Ser Leu Pro Pro Pro Ser Pro Ala His Leu Ala Ala
     340                 345                 350

 tta agt gtt gca gtc att gaa tta gca aaa gaa cat gga ata aca gat     1520
 Leu Ser Val Ala Val Ile Glu Leu Ala Lys Glu His Gly Ile Thr Asp
 355                 360                 365                 370

 gat gac ctc aga gtc cgt cag gaa att gtg gag gaa atg tca aag gtt     1568
 Asp Asp Leu Arg Val Arg Gln Glu Ile Val Glu Glu Met Ser Lys Val
                 375                 380                 385

 ata acg aca ttt tta cca gaa tgt tca ctt agg ttg tat ggc tca tct     1616
 Ile Thr Thr Phe Leu Pro Glu Cys Ser Leu Arg Leu Tyr Gly Ser Ser
             390                 395                 400

 ctg act aga ttt gct ctg aaa agt agt gat gtt aat ata gat ata aaa     1664
 Leu Thr Arg Phe Ala Leu Lys Ser Ser Asp Val Asn Ile Asp Ile Lys
         405                 410                 415

 ttt cct ccc aag atg aat cat cca gat ctt ctg ata aaa gta ctt ggg     1712
 Phe Pro Pro Lys Met Asn His Pro Asp Leu Leu Ile Lys Val Leu Gly
     420                 425                 430

 att tta aag aaa aat gta tta tat gta gat gtg gaa tct gat ttt cac     1760
 Ile Leu Lys Lys Asn Val Leu Tyr Val Asp Val Glu Ser Asp Phe His
 435                 440                 445                 450

 gct aaa gtt cct gtt gtg gtg tgc aga gat cga aaa agt ggt tta ctt     1808
 Ala Lys Val Pro Val Val Val Cys Arg Asp Arg Lys Ser Gly Leu Leu
                 455                 460                 465

 tgt aga gtg agt gca gga aac gat atg gca tgt ctc act act gat tta     1856
 Cys Arg Val Ser Ala Gly Asn Asp Met Ala Cys Leu Thr Thr Asp Leu
             470                 475                 480

 ctt act gcc ctt ggc aaa ata gaa cct gtc ttt att ccc ttg gtg tta     1904
 Leu Thr Ala Leu Gly Lys Ile Glu Pro Val Phe Ile Pro Leu Val Leu
         485                 490                 495

 gcc ttt cgc tac tgg gct aag ttg tgc tat att gac tcc caa act gat     1952
 Ala Phe Arg Tyr Trp Ala Lys Leu Cys Tyr Ile Asp Ser Gln Thr Asp
     500                 505                 510

 ggt gga atc cct tct tac tgt ttt gct tta atg gtg atg ttt ttt cta     2000
 Gly Gly Ile Pro Ser Tyr Cys Phe Ala Leu Met Val Met Phe Phe Leu
 515                 520                 525                 530

 caa cag aga aaa ccc cct ctt ctt cct tgc tta ctt gga agt tgg att     2048
 Gln Gln Arg Lys Pro Pro Leu Leu Pro Cys Leu Leu Gly Ser Trp Ile
                 535                 540                 545

 gaa ggc ttt gac cca aaa aga atg gat gac ttt cag cag aag ggc ata     2096
 Glu Gly Phe Asp Pro Lys Arg Met Asp Asp Phe Gln Gln Lys Gly Ile
             550                 555                 560

 gta gaa gag aag ttt gtg aag tgg gaa tgt aat tca agt agt gca act     2144
 Val Glu Glu Lys Phe Val Lys Trp Glu Cys Asn Ser Ser Ser Ala Thr
         565                 570                 575

 gag aaa aac tca att gct gag gaa aac aaa gct aag gca gac caa cca     2192
 Glu Lys Asn Ser Ile Ala Glu Glu Asn Lys Ala Lys Ala Asp Gln Pro
     580                 585                 590

 aaa gat gat acc aag aag aca gaa aca gac aac caa agt aat gcc atg     2240
 Lys Asp Asp Thr Lys Lys Thr Glu Thr Asp Asn Gln Ser Asn Ala Met
 595                 600                 605                 610

 aag gaa aaa cat ggc aaa tct cct tta gca ttg gaa aca cca aat cgg     2288
 Lys Glu Lys His Gly Lys Ser Pro Leu Ala Leu Glu Thr Pro Asn Arg
                 615                 620                 625

 gta tcc ttg gga cag tta tgg tta gag ctg ctt aaa ttc tac aca ctg     2336
 Val Ser Leu Gly Gln Leu Trp Leu Glu Leu Leu Lys Phe Tyr Thr Leu
             630                 635                 640

 gat ttt gct ttg gag gaa tat gtc ata tgt gta cgg ata caa gat att     2384
 Asp Phe Ala Leu Glu Glu Tyr Val Ile Cys Val Arg Ile Gln Asp Ile
         645                 650                 655

 tta aca aga gaa aat aaa aac tgg cct aaa agg cga ata gcc att gaa     2432
 Leu Thr Arg Glu Asn Lys Asn Trp Pro Lys Arg Arg Ile Ala Ile Glu
     660                 665                 670

 gat cca ttt tca gtc aag agg aat gtt gca cgg agc tta aac agc cag     2480
 Asp Pro Phe Ser Val Lys Arg Asn Val Ala Arg Ser Leu Asn Ser Gln
 675                 680                 685                 690

 ctg gtt tac gaa tat gtt gtg gag aga ttt agg gca gct tat cgg tat     2528
 Leu Val Tyr Glu Tyr Val Val Glu Arg Phe Arg Ala Ala Tyr Arg Tyr
                 695                 700                 705

 ttt gcc tgt cct cag acg aag ggt gga aat aag tct aca gtg gat ttc     2576
 Phe Ala Cys Pro Gln Thr Lys Gly Gly Asn Lys Ser Thr Val Asp Phe
             710                 715                 720

 aag aaa aga gag aag ggg aaa ata agc aat aag aaa cca gtc aag tcg     2624
 Lys Lys Arg Glu Lys Gly Lys Ile Ser Asn Lys Lys Pro Val Lys Ser
         725                 730                 735

 aac aat atg gca acc aat ggt tgt att ctg ctt ggg gaa acc aca gaa     2672
 Asn Asn Met Ala Thr Asn Gly Cys Ile Leu Leu Gly Glu Thr Thr Glu
     740                 745                 750

 aaa ata aat gca gaa aga gag caa cct gtt caa tgt gat gaa atg gac     2720
 Lys Ile Asn Ala Glu Arg Glu Gln Pro Val Gln Cys Asp Glu Met Asp
 755                 760                 765                 770

 tgt aca tca cag aga tgt att att gac aac aac aat ttg ttg gta aat     2768
 Cys Thr Ser Gln Arg Cys Ile Ile Asp Asn Asn Asn Leu Leu Val Asn
                 775                 780                 785

 gaa cta gat ttt gct gac cac gga cag gac tct tca tct ctt tct acc     2816
 Glu Leu Asp Phe Ala Asp His Gly Gln Asp Ser Ser Ser Leu Ser Thr
             790                 795                 800

 agc aaa agc agt gaa ata gag cca aaa tta gat aag aaa caa gat gat     2864
 Ser Lys Ser Ser Glu Ile Glu Pro Lys Leu Asp Lys Lys Gln Asp Asp
         805                 810                 815

 tta gcg cct tca gaa act tgt tta aaa aaa gag ctc agc caa tgt aat     2912
 Leu Ala Pro Ser Glu Thr Cys Leu Lys Lys Glu Leu Ser Gln Cys Asn
     820                 825                 830

 tgc att gat ttg tct aag tcg cct gac cca gat aaa tct act gga aca     2960
 Cys Ile Asp Leu Ser Lys Ser Pro Asp Pro Asp Lys Ser Thr Gly Thr
 835                 840                 845                 850

 gac tgc agg tca aat tta gaa aca gag agt tca cat cag agt gtg tgc     3008
 Asp Cys Arg Ser Asn Leu Glu Thr Glu Ser Ser His Gln Ser Val Cys
                 855                 860                 865

 acc gac aca tct gct acc tct tgc aac tgc aaa gct aca gaa gat gct     3056
 Thr Asp Thr Ser Ala Thr Ser Cys Asn Cys Lys Ala Thr Glu Asp Ala
             870                 875                 880

 tct gac ctt aat gat gat gat aac ctc ccc acc cag gaa tta tat tat     3104
 Ser Asp Leu Asn Asp Asp Asp Asn Leu Pro Thr Gln Glu Leu Tyr Tyr
         885                 890                 895

 gtg ttt gat aag ttt att tta acc tct ggc aag cca cca acg ata gta     3152
 Val Phe Asp Lys Phe Ile Leu Thr Ser Gly Lys Pro Pro Thr Ile Val
     900                 905                 910

 tgc agc atc tgc aaa aag gat ggc cat tca aag aat gat tgc cca gag     3200
 Cys Ser Ile Cys Lys Lys Asp Gly His Ser Lys Asn Asp Cys Pro Glu
 915                 920                 925                 930

 gat ttt agg aaa att gat tta aaa cct cta cca cca atg aca aac cga     3248
 Asp Phe Arg Lys Ile Asp Leu Lys Pro Leu Pro Pro Met Thr Asn Arg
                 935                 940                 945

 ttt cgg gaa ata ctt gat tta gta tgt aaa aga tgt ttt gat gag tta     3296
 Phe Arg Glu Ile Leu Asp Leu Val Cys Lys Arg Cys Phe Asp Glu Leu
             950                 955                 960

 tca cca cct tgt tct gaa caa cac aac agg gag caa att tta att ggc     3344
 Ser Pro Pro Cys Ser Glu Gln His Asn Arg Glu Gln Ile Leu Ile Gly
         965                 970                 975

 ttg gaa aag ttt att caa aaa gaa tat gat gaa aag gca agg ttg tgc     3392
 Leu Glu Lys Phe Ile Gln Lys Glu Tyr Asp Glu Lys Ala Arg Leu Cys
     980                 985                 990

 tta ttt ggc tct tct aag aat gga ttt gga ttt cgt gat agt gat ctg     3440
 Leu Phe Gly Ser Ser Lys Asn Gly Phe Gly Phe Arg Asp Ser Asp Leu
 995                1000                1005                1010

 gat att tgt atg acc ctg gaa ggc cat gaa aat gca gag aaa tta aat     3488
 Asp Ile Cys Met Thr Leu Glu Gly His Glu Asn Ala Glu Lys Leu Asn
                1015                1020                1025

 tgt aag gaa ata att gaa aat ttg gca aaa att ctt aag aga cat cca     3536
 Cys Lys Glu Ile Ile Glu Asn Leu Ala Lys Ile Leu Lys Arg His Pro
            1030                1035                1040

 ggt tta aga aac att ttg cct ata act act gcc aaa gtg cct ata gta     3584
 Gly Leu Arg Asn Ile Leu Pro Ile Thr Thr Ala Lys Val Pro Ile Val
        1045                1050                1055

 aaa ttt gaa cac agg cga agt ggg tta gaa ggc gat atc agt tta tat     3632
 Lys Phe Glu His Arg Arg Ser Gly Leu Glu Gly Asp Ile Ser Leu Tyr
    1060                1065                1070

 aat acg ttg gct caa cat aac aca aga atg cta gct act tat gca gct     3680
 Asn Thr Leu Ala Gln His Asn Thr Arg Met Leu Ala Thr Tyr Ala Ala
1075                1080                1085                1090

 att gat cct aga gtg cag tat ttg gga tat act atg aaa gtg ttt gct     3728
 Ile Asp Pro Arg Val Gln Tyr Leu Gly Tyr Thr Met Lys Val Phe Ala
                1095                1100                1105

 aag cga tgt gac att ggg gat gct tcc agg gga agt tta tct tca tat     3776
 Lys Arg Cys Asp Ile Gly Asp Ala Ser Arg Gly Ser Leu Ser Ser Tyr
            1110                1115                1120

 gca tat atc ctt atg gtg ctg tac ttt ctg cag cag aga aag cca cct     3824
 Ala Tyr Ile Leu Met Val Leu Tyr Phe Leu Gln Gln Arg Lys Pro Pro
        1125                1130                1135

 gtt atc cca gtt cta caa gag atc ttt gat gga aaa cag att cca cag     3872
 Val Ile Pro Val Leu Gln Glu Ile Phe Asp Gly Lys Gln Ile Pro Gln
    1140                1145                1150

 aga atg gtt gat gga tgg aat gct ttc ttc ttt gat aaa aca gaa gaa     3920
 Arg Met Val Asp Gly Trp Asn Ala Phe Phe Phe Asp Lys Thr Glu Glu
1155                1160                1165                1170

 ctg aaa aag cgt tta cct tca ctt gga aag aac aca gaa tca tta ggg     3968
 Leu Lys Lys Arg Leu Pro Ser Leu Gly Lys Asn Thr Glu Ser Leu Gly
                1175                1180                1185

 gag ctt tgg ctg gga ctg ctt cgt ttc tat act gaa gag ttt gat ttc     4016
 Glu Leu Trp Leu Gly Leu Leu Arg Phe Tyr Thr Glu Glu Phe Asp Phe
            1190                1195                1200

 aag gaa tat gta att agc att cgg cag aaa aag ctg ttg aca act ttt     4064
 Lys Glu Tyr Val Ile Ser Ile Arg Gln Lys Lys Leu Leu Thr Thr Phe
        1205                1210                1215

 gag aag cag tgg act tcc aag tgc att gca att gaa gac cct ttt gac     4112
 Glu Lys Gln Trp Thr Ser Lys Cys Ile Ala Ile Glu Asp Pro Phe Asp
    1220                1225                1230

 ttg aat cat aac ctt ggt gct gga gtt tcc aga aaa atg acc aat ttc     4160
 Leu Asn His Asn Leu Gly Ala Gly Val Ser Arg Lys Met Thr Asn Phe
1235                1240                1245                1250

 atc atg aaa gca ttt atc aat gga agg aaa ctt ttt ggt acc cct ttt     4208
 Ile Met Lys Ala Phe Ile Asn Gly Arg Lys Leu Phe Gly Thr Pro Phe
                1255                1260                1265

 tat cca ctc att ggc aga gaa gct gag tac ttc ttt gat tcc aga gta     4256
 Tyr Pro Leu Ile Gly Arg Glu Ala Glu Tyr Phe Phe Asp Ser Arg Val
            1270                1275                1280

 tta aca gat gga gaa ctg gct ccc aat gat aga tgt tgc cgt gtg tgt     4304
 Leu Thr Asp Gly Glu Leu Ala Pro Asn Asp Arg Cys Cys Arg Val Cys
        1285                1290                1295

 gga aaa ata ggc cac tac atg aaa gac tgc cct aaa agg aaa agc agt     4352
 Gly Lys Ile Gly His Tyr Met Lys Asp Cys Pro Lys Arg Lys Ser Ser
    1300                1305                1310

 tta ctg ttt aga cta aag aag aaa gac agt gaa gaa gag aag gaa ggg     4400
 Leu Leu Phe Arg Leu Lys Lys Lys Asp Ser Glu Glu Glu Lys Glu Gly
1315                1320                1325                1330

 aat gaa gaa gag aaa gat tcc cga gat gtt ctt gac ccc cga gac ctc     4448
 Asn Glu Glu Glu Lys Asp Ser Arg Asp Val Leu Asp Pro Arg Asp Leu
                1335                1340                1345

 cac gat act cga gac ttt aga gac ccg aga gac ctc aga tgt ttt ata     4496
 His Asp Thr Arg Asp Phe Arg Asp Pro Arg Asp Leu Arg Cys Phe Ile
            1350                1355                1360

 tgt gga gat gct gga cat gta cga agg gag tgc cca gag gtc aag ctg     4544
 Cys Gly Asp Ala Gly His Val Arg Arg Glu Cys Pro Glu Val Lys Leu
        1365                1370                1375

 gcc cgt cag agg aat agc agt gtg gca gca gcc cag ctg gtc cgc aac     4592
 Ala Arg Gln Arg Asn Ser Ser Val Ala Ala Ala Gln Leu Val Arg Asn
    1380                1385                1390

 ctt gta aat gct caa cag gtg gct ggt tca gct cag caa cag ggt gat     4640
 Leu Val Asn Ala Gln Gln Val Ala Gly Ser Ala Gln Gln Gln Gly Asp
1395                1400                1405                1410

 cag tcc ata agg act aga cag tca tca gaa tgt tct gaa tca cca tct     4688
 Gln Ser Ile Arg Thr Arg Gln Ser Ser Glu Cys Ser Glu Ser Pro Ser
                1415                1420                1425

 tat tct cct cag cct cag cca ttt cca cag aac tct tcc cag tca gct     4736
 Tyr Ser Pro Gln Pro Gln Pro Phe Pro Gln Asn Ser Ser Gln Ser Ala
            1430                1435                1440

 gct att act cag cct tca tct cag cca gga tcc caa cct aag ctt ggc     4784
 Ala Ile Thr Gln Pro Ser Ser Gln Pro Gly Ser Gln Pro Lys Leu Gly
        1445                1450                1455

 cca cct cag cag gga gcc caa cct ccc cat cag gtc cag atg cca ctg     4832
 Pro Pro Gln Gln Gly Ala Gln Pro Pro His Gln Val Gln Met Pro Leu
    1460                1465                1470

 tat aac ttt ccc cag tca cca cca gct cag tat tct ccc atg cac aat     4880
 Tyr Asn Phe Pro Gln Ser Pro Pro Ala Gln Tyr Ser Pro Met His Asn
1475                1480                1485                1490

 atg gga ttg ttg cca atg cac cct ctc cag atc cct gcc ccg tcc tgg     4928
 Met Gly Leu Leu Pro Met His Pro Leu Gln Ile Pro Ala Pro Ser Trp
                1495                1500                1505

 ccc atc cat ggc cca gtg atc cac tct gca cca ggc agt gcc ccc agc     4976
 Pro Ile His Gly Pro Val Ile His Ser Ala Pro Gly Ser Ala Pro Ser
            1510                1515                1520

 aat att ggc cta aat gat ccc agc atc atc ttt gca cag cct gct gcc     5024
 Asn Ile Gly Leu Asn Asp Pro Ser Ile Ile Phe Ala Gln Pro Ala Ala
        1525                1530                1535

 aga cct gtg gca atc cct aac acg tct cac gat gga cac tgg ccc cgt     5072
 Arg Pro Val Ala Ile Pro Asn Thr Ser His Asp Gly His Trp Pro Arg
    1540                1545                1550

 act gtg gct cca aat tcc ctg gta aac agt ggt gca gtg ggg aat tca     5120
 Thr Val Ala Pro Asn Ser Leu Val Asn Ser Gly Ala Val Gly Asn Ser
1555                1560                1565                1570

 gag cca ggc ttt cga gga ctg act cct cca att cct tgg gaa cat gca     5168
 Glu Pro Gly Phe Arg Gly Leu Thr Pro Pro Ile Pro Trp Glu His Ala
                1575                1580                1585

 ccg cgt ccc cat ttc ccc ctt gtc cca gct tcg tgg cct tat ggt ttg     5216
 Pro Arg Pro His Phe Pro Leu Val Pro Ala Ser Trp Pro Tyr Gly Leu
            1590                1595                1600

 cat caa aac ttc atg cat cag gga aat gcc cga ttc cag ccc aac aaa     5264
 His Gln Asn Phe Met His Gln Gly Asn Ala Arg Phe Gln Pro Asn Lys
        1605                1610                1615

 cct ttc tat act caa gac aga tgt gcc acc cgt cgg tgt aga gag cgt     5312
 Pro Phe Tyr Thr Gln Asp Arg Cys Ala Thr Arg Arg Cys Arg Glu Arg
    1620                1625                1630

 tgt ccc cac cca cca aga gga aac gtg tcg gag taa tgcg agtccatttt     5362
 Cys Pro His Pro Pro Arg Gly Asn Val Ser Glu 
1635                1640                1645

 ctttcagctg gtctaccgat gcacagcaac cagccaatcc tgctgtctca agggtatccg   5422

 tacctcaatg tcagttacat tcagcagaaa aagtgacatt taatggaaag caaaacaaat   5482

 caggtcctga tttaaaattt taacacgttt agatagctta tttaaattct aagactgttt   5542

 ttacagactg tattatttgt atataaatat gaactatagt ttttactagt atcaccaaat   5602

 tgagtgatac aaatttcatc tattttatta ccctattttt aagggaattt tatgttttgt   5662

 ttaaccttga tgaattgtat aaagagagaa tttaaaaaat tacattcttt attttctatt   5722

 agctgtattc atactttggt tgcttcagac tttatatatt gttcttaaaa gttaggaaag   5782

 aatttcatgt gttttaaatt gtcacttcta ttctttacag aaccttgtag tgccaaaaac   5842

 tttttaaaag gtaaaaaaat aaaataaaat tacaacatga agattcagat tttttttctt   5902

 ttccatactt gtatattgaa cattcaaact tgaatggaaa gttgattttg tctgtatttg   5962

 aagtacttct attttaagtt aataaatctt tttgacaaga aaaaaaaaaa a            6013




      <210> 108
      <211> 2301
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (155)..(1837)

      <400> 108
 caagacgtcc ggcctcgggg gcccgggctg ggccgcgagt cccctgggcg gcgctgagcg     60

 ggcgggaggc gggggcccgc ggctcggggc aaccgaggcc gggtcgcggg atcggccgcc    120

 atcgccgccg ccgctgcact gggagcccgc gggt    atg gag cgg gag gcg ttg     172
                                          Met Glu Arg Glu Ala Leu
                                            1               5

 ccg tgg ggc ctc gag ccc cag gat gtg cag agt tct gac gaa atg agg      220
 Pro Trp Gly Leu Glu Pro Gln Asp Val Gln Ser Ser Asp Glu Met Arg
              10                  15                  20

 agc ccc gaa ggg tac ctc aga ggc aac atg agt gag aat gag gaa gag      268
 Ser Pro Glu Gly Tyr Leu Arg Gly Asn Met Ser Glu Asn Glu Glu Glu
          25                  30                  35

 gaa att tct cag caa gaa ggc agt ggg gac tat gaa gtc gaa gag ata      316
 Glu Ile Ser Gln Gln Glu Gly Ser Gly Asp Tyr Glu Val Glu Glu Ile
      40                  45                  50

 cca ttt ggg ctt gaa ccc cag agc cct ggg ttt gag cca caa agc cca      364
 Pro Phe Gly Leu Glu Pro Gln Ser Pro Gly Phe Glu Pro Gln Ser Pro
  55                  60                  65                  70

 gag ttt gaa ccc caa agc ccc aga ttt gag cct gaa agc ccg ggg ttt      412
 Glu Phe Glu Pro Gln Ser Pro Arg Phe Glu Pro Glu Ser Pro Gly Phe
                  75                  80                  85

 gag tcc cga agc cct ggg ctt gtg ccc cca agc cct gag ttt gca ccc      460
 Glu Ser Arg Ser Pro Gly Leu Val Pro Pro Ser Pro Glu Phe Ala Pro
              90                  95                 100

 aga agc cct gaa tca gat tct cag agc cct gag ttt gaa tcc cag agc      508
 Arg Ser Pro Glu Ser Asp Ser Gln Ser Pro Glu Phe Glu Ser Gln Ser
         105                 110                 115

 cct agg tat gaa ccc caa agc cct ggc tat gaa cct cgg agc ccc ggg      556
 Pro Arg Tyr Glu Pro Gln Ser Pro Gly Tyr Glu Pro Arg Ser Pro Gly
     120                 125                 130

 tat gaa ccc cgg agc cct ggc tat gaa tct gag agc tct aga tat gaa      604
 Tyr Glu Pro Arg Ser Pro Gly Tyr Glu Ser Glu Ser Ser Arg Tyr Glu
 135                 140                 145                 150

 tcc cag aac act gag ctc aaa acc caa agc cca gaa ttt gaa gct caa      652
 Ser Gln Asn Thr Glu Leu Lys Thr Gln Ser Pro Glu Phe Glu Ala Gln
                 155                 160                 165

 agt tcc aaa ttc cag gaa ggt gcg gag atg ctt ctg aac ccc gag gaa      700
 Ser Ser Lys Phe Gln Glu Gly Ala Glu Met Leu Leu Asn Pro Glu Glu
             170                 175                 180

 aag agt cct ttg aat atc tcc gta gga gtt cac ccc ctg gac tcc ttc      748
 Lys Ser Pro Leu Asn Ile Ser Val Gly Val His Pro Leu Asp Ser Phe
         185                 190                 195

 act cag ggg ttt ggg gag cag ccc aca ggg gac ctg ccc ata ggg cca      796
 Thr Gln Gly Phe Gly Glu Gln Pro Thr Gly Asp Leu Pro Ile Gly Pro
     200                 205                 210

 cct ttt gag atg ccc aca ggg gcc ctg ctg tct aca ccg cag ttt gag      844
 Pro Phe Glu Met Pro Thr Gly Ala Leu Leu Ser Thr Pro Gln Phe Glu
 215                 220                 225                 230

 atg ctt cag aat ccc ctg ggt ctc aca gga gcc ctt cga ggt cca ggt      892
 Met Leu Gln Asn Pro Leu Gly Leu Thr Gly Ala Leu Arg Gly Pro Gly
                 235                 240                 245

 cgg cgg ggt ggc cgg gcc agg ggt ggg cag ggc cct cgg cct aac atc      940
 Arg Arg Gly Gly Arg Ala Arg Gly Gly Gln Gly Pro Arg Pro Asn Ile
             250                 255                 260

 tgt ggc atc tgc ggg aag agc ttc ggg cgg ggc tcc acc ctg atc cag      988
 Cys Gly Ile Cys Gly Lys Ser Phe Gly Arg Gly Ser Thr Leu Ile Gln
         265                 270                 275

 cac cag cgc atc cac acc ggt gag aag ccc tac aaa tgt gag gtc tgc     1036
 His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Lys Cys Glu Val Cys
     280                 285                 290

 agc aag gcc ttc tcc cag agc tct gac ctc atc aaa cac cag cgc acc     1084
 Ser Lys Ala Phe Ser Gln Ser Ser Asp Leu Ile Lys His Gln Arg Thr
 295                 300                 305                 310

 cac act ggc gag cgg ccc tac aaa tgt ccc cgt tgc ggc aag gcc ttc     1132
 His Thr Gly Glu Arg Pro Tyr Lys Cys Pro Arg Cys Gly Lys Ala Phe
                 315                 320                 325

 gcc gac agc tct tac ctg ctt cgc cac cag cgc act cac tct ggc cag     1180
 Ala Asp Ser Ser Tyr Leu Leu Arg His Gln Arg Thr His Ser Gly Gln
             330                 335                 340

 aag ccc tac aag tgc cca cat tgt ggc aag gcc ttc ggc gac agc tcc     1228
 Lys Pro Tyr Lys Cys Pro His Cys Gly Lys Ala Phe Gly Asp Ser Ser
         345                 350                 355

 tac ctc ctg cga cac cag cgc acc cac agc cac gag cgg ccc tac agc     1276
 Tyr Leu Leu Arg His Gln Arg Thr His Ser His Glu Arg Pro Tyr Ser
     360                 365                 370

 tgc acc gag tgc ggc aag tgc tat agc cag aac tcg tcc ctg cgc agc     1324
 Cys Thr Glu Cys Gly Lys Cys Tyr Ser Gln Asn Ser Ser Leu Arg Ser
 375                 380                 385                 390

 cat cag agg gtg cac acc cgg tca gag gcc ctt cag ctg tgg cat ctg     1372
 His Gln Arg Val His Thr Arg Ser Glu Ala Leu Gln Leu Trp His Leu
                 395                 400                 405

 cgg gca aga gct tct ccc agc ggt cgg ccc tta tcc ccc atg ccc gca     1420
 Arg Ala Arg Ala Ser Pro Ser Gly Arg Pro Leu Ser Pro Met Pro Ala
             410                 415                 420

 gcc acg ccc ggg aga agc cct tca agt gcc ctg agt gcg gca agc gct     1468
 Ala Thr Pro Gly Arg Ser Pro Ser Ser Ala Leu Ser Ala Ala Ser Ala
         425                 430                 435

 ttg gcc aga gct cgg tgc tgg cca tcc acg ccc gca ccc acc tgc cag     1516
 Leu Ala Arg Ala Arg Cys Trp Pro Ser Thr Pro Ala Pro Thr Cys Gln
     440                 445                 450

 gcc gca cct aca gct gcc ccg act gcg gca aga cct tca atc gct cct     1564
 Ala Ala Pro Thr Ala Ala Pro Thr Ala Ala Arg Pro Ser Ile Ala Pro
 455                 460                 465                 470

 cca ctc tca tcc agc acc agc gct ccc aca cgg gcg agc ggc cct aca     1612
 Pro Leu Ser Ser Ser Thr Ser Ala Pro Thr Arg Ala Ser Gly Pro Thr
                 475                 480                 485

 ggt gcg ccg tgt gcg gca agg gct tct gcc gct cct cca cgc ttc tgc     1660
 Gly Ala Pro Cys Ala Ala Arg Ala Ser Ala Ala Pro Pro Arg Phe Cys
             490                 495                 500

 agc atc acc ggg tcc aca gtg gcg agc ggc ctt aca agt gcg atg act     1708
 Ser Ile Thr Gly Ser Thr Val Ala Ser Gly Leu Thr Ser Ala Met Thr
         505                 510                 515

 gcg gaa agg cct tct ccc aga gct ccg acc tca tcc gcc acc agc gga     1756
 Ala Glu Arg Pro Ser Pro Arg Ala Pro Thr Ser Ser Ala Thr Ser Gly
     520                 525                 530

 ccc acg cgg cgg gcc ggc gct gac ctg ggg ccc cag cag ggg tgg gag     1804
 Pro Thr Arg Arg Ala Gly Ala Asp Leu Gly Pro Gln Gln Gly Trp Glu
 535                 540                 545                 550

 gtg tgg gca gaa gat aag ggg cca ggg agc tag aggaacct ttagggagga     1855
 Val Trp Ala Glu Asp Lys Gly Pro Gly Ser 
                 555                 560

 tagtggagaa gccgcaggag aatggaggag ctgaggatgc tggaagaaga gaaccagggt   1915

 ggaggaagtg acatgccctg gagacttgtg ggaagtgggt tggagggagg ccaggccggc   1975

 agcgggaggc cctgggagaa atggagagag gtcagcggag ggctggcctc agccgcggct   2035

 ccttggtggg tgcctggctt ggcaactgct agagcaggga ggggggaggg caggggatta   2095

 cctaattaga gtgggttagc ttagattggt agctgctgaa actctcgttg agtcaggagc   2155

 gggtaaaagg taggtggggt ggggagtggg gccccggggt ggggcctggg cctctgcgtg   2215

 caaaccccag cctccctctt cttcctcagg ctttggagcc cctgagtttg agttcaataa   2275

 aaactttatg tggtaaaaaa aaaaaa                                        2301




      <210> 109
      <211> 5394
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (351)..(3614)

      <400> 109
 atgcatgaga agcagtagat gtgtctctca ttctttcttc tttcattgcc tgctaagtac     60

 tgttgtatac cagtagcatg ggtcagagtg ggaggttgtc aacagaagag tccagcatgt    120

 atccatgatg gactctcgat caactttata tgattaactc atataaaaca gccctgtatg    180

 gaagctgagg ctgcctcttc ctagccacag gatattgacc tactttcccc ttcttatctg    240

 cttgcaaaat attggtgtac ttagtgtgtt ctccctgtca caacgaatgt tgtctctctc    300

 tttcatatga actgaaggct aaagtgctag ttaaatcagt ggacaaagca   atg gag     356
                                                          Met Glu
                                                            1

 aag aca aag ttg ctg gag acc atg gcc aaa atg gag gtg aaa acc tca      404
 Lys Thr Lys Leu Leu Glu Thr Met Ala Lys Met Glu Val Lys Thr Ser
           5                  10                  15

 ctt ctg gac aat atg att gga gtt ggg gat atg gtt ctt tta gaa cct      452
 Leu Leu Asp Asn Met Ile Gly Val Gly Asp Met Val Leu Leu Glu Pro
      20                  25                  30

 ctc aat gag gag acc ttc atc aac aac ctc aag aag cgc ttt gac cac      500
 Leu Asn Glu Glu Thr Phe Ile Asn Asn Leu Lys Lys Arg Phe Asp His
  35                  40                  45                  50

 agt gaa ata tac aca tac att gga agt gtg gtt ata tct gtt aac cca      548
 Ser Glu Ile Tyr Thr Tyr Ile Gly Ser Val Val Ile Ser Val Asn Pro
                  55                  60                  65

 tac cgg tct tta ccc att tat tca cca gag aaa gtg gaa gaa tac agg      596
 Tyr Arg Ser Leu Pro Ile Tyr Ser Pro Glu Lys Val Glu Glu Tyr Arg
              70                  75                  80

 aac aga aat ttt tat gaa ctg agc cct cac atc ttt gcc ctt tcg gat      644
 Asn Arg Asn Phe Tyr Glu Leu Ser Pro His Ile Phe Ala Leu Ser Asp
          85                  90                  95

 gaa gca tac aga tcc cta cga gat caa gat aag gac caa tgt att ctc      692
 Glu Ala Tyr Arg Ser Leu Arg Asp Gln Asp Lys Asp Gln Cys Ile Leu
     100                 105                 110

 att act ggg gaa agt gga gca gga aaa aca gag gcc agt aag ctt gtc      740
 Ile Thr Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala Ser Lys Leu Val
 115                 120                 125                 130

 atg tcc tat gtg gca gct gtt tgt gga aaa gga gca gaa gtt aat caa      788
 Met Ser Tyr Val Ala Ala Val Cys Gly Lys Gly Ala Glu Val Asn Gln
                 135                 140                 145

 gtt aaa gaa cag ctt tta cag tcc aac ccg gtc ctg gaa gct ttt gga      836
 Val Lys Glu Gln Leu Leu Gln Ser Asn Pro Val Leu Glu Ala Phe Gly
             150                 155                 160

 aat gcc aaa act gta agg aat gac aac tcc tct aga ttt ggc aaa tat      884
 Asn Ala Lys Thr Val Arg Asn Asp Asn Ser Ser Arg Phe Gly Lys Tyr
         165                 170                 175

 atg gat att gaa ttt gac ttt aaa ggc gat cca cta gga gga gta ata      932
 Met Asp Ile Glu Phe Asp Phe Lys Gly Asp Pro Leu Gly Gly Val Ile
     180                 185                 190

 agt aac tat ctt tta gag aaa tct cgg gtt gtt aaa cag cca aga ggt      980
 Ser Asn Tyr Leu Leu Glu Lys Ser Arg Val Val Lys Gln Pro Arg Gly
 195                 200                 205                 210

 gaa aga aac ttc cat gtg ttc tat cag ctg ctc tct ggt gcc tct gaa     1028
 Glu Arg Asn Phe His Val Phe Tyr Gln Leu Leu Ser Gly Ala Ser Glu
                 215                 220                 225

 gag ctc ctc aat aaa ctt aag ctt gag agg gat ttc agc agg tat aac     1076
 Glu Leu Leu Asn Lys Leu Lys Leu Glu Arg Asp Phe Ser Arg Tyr Asn
             230                 235                 240

 tac ctg agt ctg gat tcg gcc aaa gtg aat gga gtg gat gat gca gca     1124
 Tyr Leu Ser Leu Asp Ser Ala Lys Val Asn Gly Val Asp Asp Ala Ala
         245                 250                 255

 aat ttt aga acc gtg cgg aat gcc atg cag att gtg ggc ttt atg gat     1172
 Asn Phe Arg Thr Val Arg Asn Ala Met Gln Ile Val Gly Phe Met Asp
     260                 265                 270

 cat gaa gct gag tct gtc ttg gcg gtg gtg gca gca gtg ttg aaa ctg     1220
 His Glu Ala Glu Ser Val Leu Ala Val Val Ala Ala Val Leu Lys Leu
 275                 280                 285                 290

 ggg aac att gag ttc aag ccc gaa tct cga gtg aat ggt cta gat gaa     1268
 Gly Asn Ile Glu Phe Lys Pro Glu Ser Arg Val Asn Gly Leu Asp Glu
                 295                 300                 305

 agc aaa atc aaa gat aaa aat gag tta aaa gaa att tgt gaa ttg acc     1316
 Ser Lys Ile Lys Asp Lys Asn Glu Leu Lys Glu Ile Cys Glu Leu Thr
             310                 315                 320

 ggc att gat caa tca gtt cta gaa cga gca ttc agt ttc cga aca gtt     1364
 Gly Ile Asp Gln Ser Val Leu Glu Arg Ala Phe Ser Phe Arg Thr Val
         325                 330                 335

 gag gcc aaa cag gag aaa gtt tca act aca ctg aat gtg gct cag gct     1412
 Glu Ala Lys Gln Glu Lys Val Ser Thr Thr Leu Asn Val Ala Gln Ala
     340                 345                 350

 tat tat gcc cgt gat gct ctg gct aaa aac ctc tac agc agg ttg ttt     1460
 Tyr Tyr Ala Arg Asp Ala Leu Ala Lys Asn Leu Tyr Ser Arg Leu Phe
 355                 360                 365                 370

 tca tgg ttg gta aat cga atc aat gaa agc att aag gca caa aca aaa     1508
 Ser Trp Leu Val Asn Arg Ile Asn Glu Ser Ile Lys Ala Gln Thr Lys
                 375                 380                 385

 gtg aga aag aag gtc atg ggt gtt ctg gac att tat ggc ttt gag att     1556
 Val Arg Lys Lys Val Met Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile
             390                 395                 400

 ttc gag gac aac agc ttt gag cag ttc att att aat tat tgt aac gaa     1604
 Phe Glu Asp Asn Ser Phe Glu Gln Phe Ile Ile Asn Tyr Cys Asn Glu
         405                 410                 415

 aag ctg caa caa atc ttc att gaa ctt act ctt aaa gaa gag cag gag     1652
 Lys Leu Gln Gln Ile Phe Ile Glu Leu Thr Leu Lys Glu Glu Gln Glu
     420                 425                 430

 gag tat ata cgg gag gat ata gaa tgg act cac att gac tac ttc aat     1700
 Glu Tyr Ile Arg Glu Asp Ile Glu Trp Thr His Ile Asp Tyr Phe Asn
 435                 440                 445                 450

 aat gct atc att tgt gac cta ata gaa aat aac aca aat gga atc ctg     1748
 Asn Ala Ile Ile Cys Asp Leu Ile Glu Asn Asn Thr Asn Gly Ile Leu
                 455                 460                 465

 gcc atg ctg gat gaa gag tgc ctc aga cct ggc aca gtc act gat gag     1796
 Ala Met Leu Asp Glu Glu Cys Leu Arg Pro Gly Thr Val Thr Asp Glu
             470                 475                 480

 acc ttc tta gaa aag ctg aac caa gta tgt gcc acc cac cag cat ttt     1844
 Thr Phe Leu Glu Lys Leu Asn Gln Val Cys Ala Thr His Gln His Phe
         485                 490                 495

 gag agc agg atg agc aag tgc tct cgg ttc ctc aat gac acg tct ctg     1892
 Glu Ser Arg Met Ser Lys Cys Ser Arg Phe Leu Asn Asp Thr Ser Leu
     500                 505                 510

 cct cac agc tgc ttc agg atc cag cat tat gct gga aag gtg ctg tac     1940
 Pro His Ser Cys Phe Arg Ile Gln His Tyr Ala Gly Lys Val Leu Tyr
 515                 520                 525                 530

 cag gtg gaa gga ttc gtt gac aaa aac aat gac ctt ctc tat cga gac     1988
 Gln Val Glu Gly Phe Val Asp Lys Asn Asn Asp Leu Leu Tyr Arg Asp
                 535                 540                 545

 ctg tcc caa gcc atg tgg aag gcc agc cat gcc ctc atc aag tct ttg     2036
 Leu Ser Gln Ala Met Trp Lys Ala Ser His Ala Leu Ile Lys Ser Leu
             550                 555                 560

 ttc ccc gaa ggg aat ccc gcc aag atc aac ctg aaa agg cct cct aca     2084
 Phe Pro Glu Gly Asn Pro Ala Lys Ile Asn Leu Lys Arg Pro Pro Thr
         565                 570                 575

 gca ggc tca cag ttc aag gca tcc gtg gcc act ctg atg aaa aac cta     2132
 Ala Gly Ser Gln Phe Lys Ala Ser Val Ala Thr Leu Met Lys Asn Leu
     580                 585                 590

 cag acc aag aac cca aac tat att agg tgt atc aaa ccg aat gat aaa     2180
 Gln Thr Lys Asn Pro Asn Tyr Ile Arg Cys Ile Lys Pro Asn Asp Lys
 595                 600                 605                 610

 aaa gca gca cac atc ttc aac gag gct cta gtg tgt cat cag atc agg     2228
 Lys Ala Ala His Ile Phe Asn Glu Ala Leu Val Cys His Gln Ile Arg
                 615                 620                 625

 tac ctg ggg ctt ttg gag aac gtc cga gtg cgg agg gca ggc tac gcc     2276
 Tyr Leu Gly Leu Leu Glu Asn Val Arg Val Arg Arg Ala Gly Tyr Ala
             630                 635                 640

 ttc agg cag gcc tat gaa cct tgc cta gaa aga tac aaa atg ctt tgt     2324
 Phe Arg Gln Ala Tyr Glu Pro Cys Leu Glu Arg Tyr Lys Met Leu Cys
         645                 650                 655

 aaa caa aca tgg cct cat tgg aaa gga cca gcc agg tct ggt gtg gag     2372
 Lys Gln Thr Trp Pro His Trp Lys Gly Pro Ala Arg Ser Gly Val Glu
     660                 665                 670

 gtc cta ttt aat gaa tta gaa att ccc gtg gaa gaa tac tcc ttt ggt     2420
 Val Leu Phe Asn Glu Leu Glu Ile Pro Val Glu Glu Tyr Ser Phe Gly
 675                 680                 685                 690

 aga tca aag ata ttc atc cga aac cca aga aca tta ttc aaa tta gaa     2468
 Arg Ser Lys Ile Phe Ile Arg Asn Pro Arg Thr Leu Phe Lys Leu Glu
                 695                 700                 705

 gac ctg agg aag caa cgc ctg gag gac ttg gcc act ctc att cag aag     2516
 Asp Leu Arg Lys Gln Arg Leu Glu Asp Leu Ala Thr Leu Ile Gln Lys
             710                 715                 720

 ata tat cgg ggg tgg aaa tgc cgc aca cac ttc ctg cta atg aaa aaa     2564
 Ile Tyr Arg Gly Trp Lys Cys Arg Thr His Phe Leu Leu Met Lys Lys
         725                 730                 735

 agc caa att gtg att gcc gcc tgg tac agg aga tat gcg caa caa aag     2612
 Ser Gln Ile Val Ile Ala Ala Trp Tyr Arg Arg Tyr Ala Gln Gln Lys
     740                 745                 750

 agg tac cag cag aca aag agt tcc gcc tta gta att cag tct tat atc     2660
 Arg Tyr Gln Gln Thr Lys Ser Ser Ala Leu Val Ile Gln Ser Tyr Ile
 755                 760                 765                 770

 cgg ggt tgg aag gct cga aaa att ctg cgg gaa ctg aag cat caa aag     2708
 Arg Gly Trp Lys Ala Arg Lys Ile Leu Arg Glu Leu Lys His Gln Lys
                 775                 780                 785

 cgc tgt aag gaa gca gtc acg acc att gct gca tat tgg cat ggg acc     2756
 Arg Cys Lys Glu Ala Val Thr Thr Ile Ala Ala Tyr Trp His Gly Thr
             790                 795                 800

 cag gta cgt aga gaa tac agg aaa ttc ttc aga gcc aat gct gga aag     2804
 Gln Val Arg Arg Glu Tyr Arg Lys Phe Phe Arg Ala Asn Ala Gly Lys
         805                 810                 815

 aaa atc tat gag ttt acg ctt cag aga att gtg caa aaa tac ttc ttg     2852
 Lys Ile Tyr Glu Phe Thr Leu Gln Arg Ile Val Gln Lys Tyr Phe Leu
     820                 825                 830

 gaa atg aaa aat aag atg cct tcc tta tct cca ata gac aag aat tgg     2900
 Glu Met Lys Asn Lys Met Pro Ser Leu Ser Pro Ile Asp Lys Asn Trp
 835                 840                 845                 850

 ccc tca aga cct tac tta ttc ttg gat tct act cac aag gag cta aaa     2948
 Pro Ser Arg Pro Tyr Leu Phe Leu Asp Ser Thr His Lys Glu Leu Lys
                 855                 860                 865

 agg att ttc cac ttg tgg agg tgt aaa aaa tac agg gac caa ttc aca     2996
 Arg Ile Phe His Leu Trp Arg Cys Lys Lys Tyr Arg Asp Gln Phe Thr
             870                 875                 880

 gac cag cag aaa ctt att tat gaa gag aaa cta gaa gcc agt gaa ctc     3044
 Asp Gln Gln Lys Leu Ile Tyr Glu Glu Lys Leu Glu Ala Ser Glu Leu
         885                 890                 895

 ttc aaa gac aag aag gct tta tac cca tct agt gtt ggg caa cca ttc     3092
 Phe Lys Asp Lys Lys Ala Leu Tyr Pro Ser Ser Val Gly Gln Pro Phe
     900                 905                 910

 caa ggg gct tac ctg gaa atc aac aag aac ccc aag tat aag aaa ctc     3140
 Gln Gly Ala Tyr Leu Glu Ile Asn Lys Asn Pro Lys Tyr Lys Lys Leu
 915                 920                 925                 930

 aaa gat gcc att gaa gaa aag atc atc att gct gaa gtc gtg aac aaa     3188
 Lys Asp Ala Ile Glu Glu Lys Ile Ile Ile Ala Glu Val Val Asn Lys
                 935                 940                 945

 att aac cgt gct aat ggg aag agt aca tct cgg att ttc ctc tta aca     3236
 Ile Asn Arg Ala Asn Gly Lys Ser Thr Ser Arg Ile Phe Leu Leu Thr
             950                 955                 960

 aac aat aat ctc ctt ctt gct gac caa aag tct gga caa atc aag tca     3284
 Asn Asn Asn Leu Leu Leu Ala Asp Gln Lys Ser Gly Gln Ile Lys Ser
         965                 970                 975

 gag gtt cca ttg gtg gat gtg acc aag gta tca atg agc tca caa aat     3332
 Glu Val Pro Leu Val Asp Val Thr Lys Val Ser Met Ser Ser Gln Asn
     980                 985                 990

 gat ggc ttc ttc gcc gtc cac ctc aaa gag ggc tca gaa gca gct agt     3380
 Asp Gly Phe Phe Ala Val His Leu Lys Glu Gly Ser Glu Ala Ala Ser
 995                1000                1005                1010

 aaa gga gac ttt ctc ttc agc agt gat cac ctg att gaa atg gcc acc     3428
 Lys Gly Asp Phe Leu Phe Ser Ser Asp His Leu Ile Glu Met Ala Thr
                1015                1020                1025

 aag ctc tat cgc aca act ctc agc caa acc aaa cag aag ctc aat att     3476
 Lys Leu Tyr Arg Thr Thr Leu Ser Gln Thr Lys Gln Lys Leu Asn Ile
            1030                1035                1040

 gag att tcc gat gag ttc ctg gta cag ttc aga cag gac aaa gta tgt     3524
 Glu Ile Ser Asp Glu Phe Leu Val Gln Phe Arg Gln Asp Lys Val Cys
        1045                1050                1055

 gtg aag ttt att cag gga aac cag aaa aat ggg agt gtc cca aca tgt     3572
 Val Lys Phe Ile Gln Gly Asn Gln Lys Asn Gly Ser Val Pro Thr Cys
    1060                1065                1070

 aaa cga aaa aac aac cgt ctc ctt gaa gtt gct gtc cct taa ctggcgc     3621
 Lys Arg Lys Asn Asn Arg Leu Leu Glu Val Ala Val Pro 
1075                1080                1085

 ctcctctcta ctttcatgga cttgttcctt tgtaatagtg caatttggtt ttgttttatt   3681

 tggggttcat tgtatgtttg ggaatcacca aaggctttta gagttctttg gcaaaataaa   3741

 aatatttgac taatcaattt ttattattgg aatagtttta acctttcaaa tacatgttct   3801

 gtcctggagc aggattgtag aaactaacag tgtctatttt catgtctgat gtgttcttcc   3861

 tttagtcatc atgttaggtc tgtgtaccct aaatcagcat attactcata aatcattaat   3921

 taatataagc ataggaaatg gtcttaaaag atactgcatt cattcatcag atatttattc   3981

 catgcctact ctatgctagg cactgtgcta gatggtatga aaacttatta ggaacctttt   4041

 tgtttttgag accattgcat tctggctggt ttgtgctggt ttaacgacat ctaagaaggt   4101

 ttagaaatgg tgagaccaaa acaataactg ttaatgatgg acagcattat taggaaccct   4161

 gtagtatgat atttaacaat ataggcttca agaagggctg gtcctaagag ggggcagaaa   4221

 tgaatgacca ggttaaatcc ctctacatgt ggtttctgtt tgaaaaaaag aaaactgaca   4281

 tttgaacagg acttttaatt tgtttaaaac tctggtaatt acttgtaaca gtagaaaata   4341

 gaagtcattc ttattttaga aaaagtgaca gaagcagtcc agtaagatta tatgtttctg   4401

 tttctggtaa ataccatata tgatcctcga aatgataata tctccagaat attgttttca   4461

 cccaaatttg agtagatatt ttaaacacct aacaaagtaa agggctaaaa gccattcaga   4521

 tagcagtaaa acattctgta tgatgtgcaa taaaacatcc aagatctttt ttgaaagttt   4581

 tatttataat atacattttt gtatgagaaa ggtgattggt acagggtgcc tattttagtc   4641

 atggatcaaa atttgtgtaa cttgcagggc tttctttctt tttcttcaaa tttacaaggg   4701

 ttcattttgg aaactacatt ttaaactttg gaatcaaatt gtttcttatt tgggaggata   4761

 atgtatatac attggtatta tgttaaataa taaaattgtt ctaatttggt gccatttcct   4821

 gaatcacaac tgtatttttg tatctcaagc tattttcata tgttatgtgt caatgtatca   4881

 tctctcagaa aggttttaca atccaaacat tatatgttct ctgtgtaact gaatttcact   4941

 tatcttttat aaaccagaaa cattaattga aaatattttc tggggatttt ctcttgactt   5001

 gtatttttaa aaattgctca cataaagaag ttctcagaag tctttgtgtt tattggtgca   5061

 ggtagaggat gtaattactt agattcttct tgccttgtgc ctaaagtggt agattaatag   5121

 ttcctgatac tggtgagtag aaatttggga atgagagggt gtggtgtttt aaataacatg   5181

 cagtatgttc acattgttca gcatgtaagt aagtgttaaa atatatacat tacaaattct   5241

 ccatcctatc aaccagctat ctgcttagtt cccaccctcc ccgaaacatt aaccattgtt   5301

 gttagttgct tttgtattac tttgtccata tgtttgcaaa aggaaatcaa aatagattct   5361

 tacgtttttt tgctttagta gaaaaaaaaa aaa                                5394




      <210> 110
      <211> 2899
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(2899)

      <400> 110
 gggaaggagc gaaggagcga aggagcaagc ggagcgcagt tcgcccaagc caagccgcgc     60

 tgccaaccct cccgcccgcc cgcgctcctg tccgccgtgt ctagcagcgg ggcccagc      118                                                                 
 atg gtc atg gcg gat ggc ccg agg cac ttg cag cgc ggg ccg gtc cgg      166
 Met Val Met Ala Asp Gly Pro Arg His Leu Gln Arg Gly Pro Val Arg
   1               5                  10                  15

 gtg ggg ttc tac gac atc gag ggc acg ctg ggc aag ggc aac ttc gct      214
 Val Gly Phe Tyr Asp Ile Glu Gly Thr Leu Gly Lys Gly Asn Phe Ala
              20                  25                  30

 gtg gtg aag ctg ggg cgg cac cgg atc acc aag acg gag gtg gca ata      262
 Val Val Lys Leu Gly Arg His Arg Ile Thr Lys Thr Glu Val Ala Ile
          35                  40                  45

 aaa ata atc gat aag tct cag ctg gat gca gtg aac ctt gag aaa atc      310
 Lys Ile Ile Asp Lys Ser Gln Leu Asp Ala Val Asn Leu Glu Lys Ile
      50                  55                  60

 tac cga gaa gta caa ata atg aaa atg tta gac cac cct cac ata atc      358
 Tyr Arg Glu Val Gln Ile Met Lys Met Leu Asp His Pro His Ile Ile
  65                  70                  75                  80

 aaa ctt tat cag gta atg gag acc aaa agt atg ttg tac ctt gtg aca      406
 Lys Leu Tyr Gln Val Met Glu Thr Lys Ser Met Leu Tyr Leu Val Thr
                  85                  90                  95

 gaa tat gcc aaa aat gga gaa att ttt gac tat ctt gct aat cat ggc      454
 Glu Tyr Ala Lys Asn Gly Glu Ile Phe Asp Tyr Leu Ala Asn His Gly
             100                 105                 110

 cgg tta aat gag tct gaa gcc agg cga aaa ttc tgg caa atc ctg tct      502
 Arg Leu Asn Glu Ser Glu Ala Arg Arg Lys Phe Trp Gln Ile Leu Ser
         115                 120                 125

 gct gtt gat tat tgt cat ggt cgg aag att gtg cac cgt gac ctc aaa      550
 Ala Val Asp Tyr Cys His Gly Arg Lys Ile Val His Arg Asp Leu Lys
     130                 135                 140

 gct gaa aat ctc ctg ctg gat aac aac atg aat atc aaa ata gca gat      598
 Ala Glu Asn Leu Leu Leu Asp Asn Asn Met Asn Ile Lys Ile Ala Asp
 145                 150                 155                 160

 ttc ggt ttt gga aat ttc ttt aaa agt ggt gaa ctg ctg gca aca tgg      646
 Phe Gly Phe Gly Asn Phe Phe Lys Ser Gly Glu Leu Leu Ala Thr Trp
                 165                 170                 175

 tgt ggc agc ccc cct tat gca gcc cca gaa gtc ttt gaa ggg cag cag      694
 Cys Gly Ser Pro Pro Tyr Ala Ala Pro Glu Val Phe Glu Gly Gln Gln
             180                 185                 190

 tat gaa gga cca cag ctg gac atc tgg agt atg gga gtt gtt ctt tat      742
 Tyr Glu Gly Pro Gln Leu Asp Ile Trp Ser Met Gly Val Val Leu Tyr
         195                 200                 205

 gtc ctt gtc tgt gga gct ctg ccc ttt gat gga ccg act ctt cca att      790
 Val Leu Val Cys Gly Ala Leu Pro Phe Asp Gly Pro Thr Leu Pro Ile
     210                 215                 220

 ttg agg cag agg gtt ctg gaa gga aga ttc cgg att ccg tat ttc atg      838
 Leu Arg Gln Arg Val Leu Glu Gly Arg Phe Arg Ile Pro Tyr Phe Met
 225                 230                 235                 240

 tca gaa gat tgc gag cac ctt atc cga agg atg ttg gtc cta gac cca      886
 Ser Glu Asp Cys Glu His Leu Ile Arg Arg Met Leu Val Leu Asp Pro
                 245                 250                 255

 tcc aaa cgg cta acc ata gcc caa atc aag gag cat aaa tgg atg ctc      934
 Ser Lys Arg Leu Thr Ile Ala Gln Ile Lys Glu His Lys Trp Met Leu
             260                 265                 270

 ata gaa gtt cct gtc cag aga cct gtt ctc tat cca caa gag caa gaa      982
 Ile Glu Val Pro Val Gln Arg Pro Val Leu Tyr Pro Gln Glu Gln Glu
         275                 280                 285

 aat gag cca tcc atc ggg gag ttt aat gag cag gtt ctg cga ctg atg     1030
 Asn Glu Pro Ser Ile Gly Glu Phe Asn Glu Gln Val Leu Arg Leu Met
     290                 295                 300

 cac agc ctt gga ata gat cag cag aaa acc att gag tct ttg cag aac     1078
 His Ser Leu Gly Ile Asp Gln Gln Lys Thr Ile Glu Ser Leu Gln Asn
 305                 310                 315                 320

 aag agc tat aac cac ttt gct gcc att tat ttc ttg ttg gtg gag cgc     1126
 Lys Ser Tyr Asn His Phe Ala Ala Ile Tyr Phe Leu Leu Val Glu Arg
                 325                 330                 335

 ctg aaa tca cat cgg agc agt ttc cca gtg gag cag aga ctt gat ggc     1174
 Leu Lys Ser His Arg Ser Ser Phe Pro Val Glu Gln Arg Leu Asp Gly
             340                 345                 350

 cgc cag cgt cgg cct agc acc att gct gag caa aca gtt gcc aag gca     1222
 Arg Gln Arg Arg Pro Ser Thr Ile Ala Glu Gln Thr Val Ala Lys Ala
         355                 360                 365

 cag act gtg ggg ctc cca gtg acc atg cat tca ccg aac atg agg ctg     1270
 Gln Thr Val Gly Leu Pro Val Thr Met His Ser Pro Asn Met Arg Leu
     370                 375                 380

 ctg cga tct gcc ctc ctc ccc cag gca tcc aac gtg gag gcc ttt tca     1318
 Leu Arg Ser Ala Leu Leu Pro Gln Ala Ser Asn Val Glu Ala Phe Ser
 385                 390                 395                 400

 ttt cca gca tct ggc tgt cag gcg gaa gct gca ttc atg gaa gaa gag     1366
 Phe Pro Ala Ser Gly Cys Gln Ala Glu Ala Ala Phe Met Glu Glu Glu
                 405                 410                 415

 tgt gtg gac act cca aag gtc aat ggc tgt ctg ctt gac cct gtg cct     1414
 Cys Val Asp Thr Pro Lys Val Asn Gly Cys Leu Leu Asp Pro Val Pro
             420                 425                 430

 cct gtc ctg gtg cgg aag gga tgc cag tca ctg ccc agc aac atg atg     1462
 Pro Val Leu Val Arg Lys Gly Cys Gln Ser Leu Pro Ser Asn Met Met
         435                 440                 445

 gag acc tcc att gac gaa ggg ctg gag aca gaa gga gag gcc gag gaa     1510
 Glu Thr Ser Ile Asp Glu Gly Leu Glu Thr Glu Gly Glu Ala Glu Glu
     450                 455                 460

 gac ccc gct cat gcc ttt gag gca ttt cag tcc aca cgc agc ggg cag     1558
 Asp Pro Ala His Ala Phe Glu Ala Phe Gln Ser Thr Arg Ser Gly Gln
 465                 470                 475                 480

 aga cgg cac act ctg tca gaa gtg acc aat caa ctg gtc gtg atg cct     1606
 Arg Arg His Thr Leu Ser Glu Val Thr Asn Gln Leu Val Val Met Pro
                 485                 490                 495

 ggg gca ggg aaa att ttc tcc atg aat gac agc ccc tcc ctt gac agt     1654
 Gly Ala Gly Lys Ile Phe Ser Met Asn Asp Ser Pro Ser Leu Asp Ser
             500                 505                 510

 gtg gac tct gag tat gat atg ggg tct gtt cag agg gac ctg aac ttt     1702
 Val Asp Ser Glu Tyr Asp Met Gly Ser Val Gln Arg Asp Leu Asn Phe
         515                 520                 525

 ctg gaa gac aac cct tcc ctt aag gac atc atg tta gcc aat cag cct     1750
 Leu Glu Asp Asn Pro Ser Leu Lys Asp Ile Met Leu Ala Asn Gln Pro
     530                 535                 540

 tca ccc cgc atg aca tct ccc ttc ata agc ctg aga cct acc aac cca     1798
 Ser Pro Arg Met Thr Ser Pro Phe Ile Ser Leu Arg Pro Thr Asn Pro
 545                 550                 555                 560

 gcc atg cag gct ctg agc tcc cag aaa cga gag gtc cac aac agg tct     1846
 Ala Met Gln Ala Leu Ser Ser Gln Lys Arg Glu Val His Asn Arg Ser
                 565                 570                 575

 cca gtg agc ttc aga gag ggc cgc aga gca tca gat acc tcc ctc acc     1894
 Pro Val Ser Phe Arg Glu Gly Arg Arg Ala Ser Asp Thr Ser Leu Thr
             580                 585                 590

 cag gga att gta gca ttt aga caa cat ctt cag aat ctg gct aga acc     1942
 Gln Gly Ile Val Ala Phe Arg Gln His Leu Gln Asn Leu Ala Arg Thr
         595                 600                 605

 aaa gga att cta gag ttg aac aaa gtg cag ttg ttg tat gaa caa ata     1990
 Lys Gly Ile Leu Glu Leu Asn Lys Val Gln Leu Leu Tyr Glu Gln Ile
     610                 615                 620

 gga ccg gag gca gac cct aac ctg gcg ccg gcg gct cct cag ctc cag     2038
 Gly Pro Glu Ala Asp Pro Asn Leu Ala Pro Ala Ala Pro Gln Leu Gln
 625                 630                 635                 640

 gac ctt gct agc agc tgc cct cag gaa gaa gtt tct cag cag cag gaa     2086
 Asp Leu Ala Ser Ser Cys Pro Gln Glu Glu Val Ser Gln Gln Gln Glu
                 645                 650                 655

 agc gtc tcc act ctc cct gcc agc gtg cat ccc cag ctg tcc cca cgg     2134
 Ser Val Ser Thr Leu Pro Ala Ser Val His Pro Gln Leu Ser Pro Arg
             660                 665                 670

 cag agc ctg gag acc cag tac ctg cag cac aga ctc cag aag ccc agc     2182
 Gln Ser Leu Glu Thr Gln Tyr Leu Gln His Arg Leu Gln Lys Pro Ser
         675                 680                 685

 ctt ctg tca aag gcc cag aac acc tgt cag ctt tat tgc aaa gaa cca     2230
 Leu Leu Ser Lys Ala Gln Asn Thr Cys Gln Leu Tyr Cys Lys Glu Pro
     690                 695                 700

 ccg cgg agc ctt gag cag cag ctg cag gaa cat agg ctc cag cag aag     2278
 Pro Arg Ser Leu Glu Gln Gln Leu Gln Glu His Arg Leu Gln Gln Lys
 705                 710                 715                 720

 cga ctc ttt ctt cag aag cag tct caa ctg cag gcc tat ttt aat cag     2326
 Arg Leu Phe Leu Gln Lys Gln Ser Gln Leu Gln Ala Tyr Phe Asn Gln
                 725                 730                 735

 atg cag ata gca gag agc tcc tac cca cag cca agt cag cag ctg ccc     2374
 Met Gln Ile Ala Glu Ser Ser Tyr Pro Gln Pro Ser Gln Gln Leu Pro
             740                 745                 750

 ctt ccc cgc cag gag act cca ccg cct tct cag cag gcc cca ccg ttc     2422
 Leu Pro Arg Gln Glu Thr Pro Pro Pro Ser Gln Gln Ala Pro Pro Phe
         755                 760                 765

 agc ctg acc cag ccc ctg agc ccc gtc ctg gag cct tcc tcc gag cag     2470
 Ser Leu Thr Gln Pro Leu Ser Pro Val Leu Glu Pro Ser Ser Glu Gln
     770                 775                 780

 atg caa tac agc cct ttc ctc agc cag tac caa gag atg cag ctt cag     2518
 Met Gln Tyr Ser Pro Phe Leu Ser Gln Tyr Gln Glu Met Gln Leu Gln
 785                 790                 795                 800

 ccc ctg ccc tcc act tcc ggt ccc cgg gct gct cct cct ctg ccc acg     2566
 Pro Leu Pro Ser Thr Ser Gly Pro Arg Ala Ala Pro Pro Leu Pro Thr
                 805                 810                 815

 cag cta cag cag cag cag ccg cca ccg cca cca ccc cct cca cca cca     2614
 Gln Leu Gln Gln Gln Gln Pro Pro Pro Pro Pro Pro Pro Pro Pro Pro
             820                 825                 830

 cga cag cca gga gct gcc cca gcc ccc tta cag ttc tcc tat cag act     2662
 Arg Gln Pro Gly Ala Ala Pro Ala Pro Leu Gln Phe Ser Tyr Gln Thr
         835                 840                 845

 tgt gag ctg cca agc gct gct tcc cct gcg cca gac tat ccc act ccc     2710
 Cys Glu Leu Pro Ser Ala Ala Ser Pro Ala Pro Asp Tyr Pro Thr Pro
     850                 855                 860

 tgt cag tat cct gtg gat gga gcc cag cag agc gac cta acg ggg cca     2758
 Cys Gln Tyr Pro Val Asp Gly Ala Gln Gln Ser Asp Leu Thr Gly Pro
 865                 870                 875                 880

 gac tgt ccc aga agc cca gga ctg caa gag gcc ccc tcc agc tac gac     2806
 Asp Cys Pro Arg Ser Pro Gly Leu Gln Glu Ala Pro Ser Ser Tyr Asp
                 885                 890                 895

 cca cta gcc ctc tct gag cta cct gga ctc ttt gat tgt gaa atg cta     2854
 Pro Leu Ala Leu Ser Glu Leu Pro Gly Leu Phe Asp Cys Glu Met Leu
             900                 905                 910

 gac gct gtg gat cca caa cac aac ggg tat gtc ctg gtg aat tag         2899
 Asp Ala Val Asp Pro Gln His Asn Gly Tyr Val Leu Val Asn 
         915                 920                 925





      <210> 111
      <211> 1994
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(1680)

      <400> 111
 agctgggacc tcagcatcaa caacagcaac ttgtgattgg cggtgaccgg atattcagtt     60

 gcacatcccc acatcaatgc actgccaatg ggttatatcc tgtgttgtga cctcatggtt    120

 taagtgggaa taaag atg agt ata agc agt gat gag gtc aac ttc ttg gta     171
                  Met Ser Ile Ser Ser Asp Glu Val Asn Phe Leu Val
                    1               5                  10

 tat aga tac ttg caa gag tca gga ttt tct cat tca gca ttt acc ttt      219
 Tyr Arg Tyr Leu Gln Glu Ser Gly Phe Ser His Ser Ala Phe Thr Phe
          15                  20                  25

 ggt ata gaa agc cat atc agt cag tcc aat ata aat ggt gcc ctc gtc      267
 Gly Ile Glu Ser His Ile Ser Gln Ser Asn Ile Asn Gly Ala Leu Val
      30                  35                  40

 cca ccc gct gca ttg att tct atc atc cag aaa ggt cta cag tat gta      315
 Pro Pro Ala Ala Leu Ile Ser Ile Ile Gln Lys Gly Leu Gln Tyr Val
  45                  50                  55                  60

 gaa gca gaa gtt agt att aat gag gat ggt acc ttg ttt gat ggt cga      363
 Glu Ala Glu Val Ser Ile Asn Glu Asp Gly Thr Leu Phe Asp Gly Arg
                  65                  70                  75

 cca ata gag tct ctg tcc ctg ata gat gcc gta atg cct gat gta gta      411
 Pro Ile Glu Ser Leu Ser Leu Ile Asp Ala Val Met Pro Asp Val Val
              80                  85                  90

 caa aca aga caa caa gct tat aga gat aag ctt gca cag caa cag gca      459
 Gln Thr Arg Gln Gln Ala Tyr Arg Asp Lys Leu Ala Gln Gln Gln Ala
          95                 100                 105

 gca gct gct gca gct gcc gca gct gca gcc agc caa caa gga tct gca      507
 Ala Ala Ala Ala Ala Ala Ala Ala Ala Ala Ser Gln Gln Gly Ser Ala
     110                 115                 120

 aaa aat gga gaa aac aca gca aat ggg gag gag aat gga gca cat act      555
 Lys Asn Gly Glu Asn Thr Ala Asn Gly Glu Glu Asn Gly Ala His Thr
 125                 130                 135                 140

 ata gca aat aat cat act gat atg atg gaa gtg gat ggg gat gtt gaa      603
 Ile Ala Asn Asn His Thr Asp Met Met Glu Val Asp Gly Asp Val Glu
                 145                 150                 155

 atc cct cct aat aaa gct gtt gtg ttg cgg ggc cat gaa tct gaa gtt      651
 Ile Pro Pro Asn Lys Ala Val Val Leu Arg Gly His Glu Ser Glu Val
             160                 165                 170

 ttt atc tgt gcc tgg aac cct gtt agt gat ctc cta gca tca ggg tct      699
 Phe Ile Cys Ala Trp Asn Pro Val Ser Asp Leu Leu Ala Ser Gly Ser
         175                 180                 185

 gga gac tca aca gca aga ata tgg aat ctt agt gag aac agc acc agt      747
 Gly Asp Ser Thr Ala Arg Ile Trp Asn Leu Ser Glu Asn Ser Thr Ser
     190                 195                 200

 ggc tct aca cag tta gta ctt aga cat tgt ata cga gaa gga ggg caa      795
 Gly Ser Thr Gln Leu Val Leu Arg His Cys Ile Arg Glu Gly Gly Gln
 205                 210                 215                 220

 gat gtt cca agc aac aag gat gtc aca tct cta gat tgg aat agt gaa      843
 Asp Val Pro Ser Asn Lys Asp Val Thr Ser Leu Asp Trp Asn Ser Glu
                 225                 230                 235

 ggt aca ctt cta gca act ggt tcc tat gat ggg ttt gcc aga ata tgg      891
 Gly Thr Leu Leu Ala Thr Gly Ser Tyr Asp Gly Phe Ala Arg Ile Trp
             240                 245                 250

 act aaa gat ggt aac ctt gct agc acc tta ggg cag cat aaa ggc cct      939
 Thr Lys Asp Gly Asn Leu Ala Ser Thr Leu Gly Gln His Lys Gly Pro
         255                 260                 265

 ata ttt gca tta aaa tgg aat aag aaa gga aat ttc atc cta agt gct      987
 Ile Phe Ala Leu Lys Trp Asn Lys Lys Gly Asn Phe Ile Leu Ser Ala
     270                 275                 280

 gga gta gac aag act aca att att tgg gac gca cat act ggt gaa gcc     1035
 Gly Val Asp Lys Thr Thr Ile Ile Trp Asp Ala His Thr Gly Glu Ala
 285                 290                 295                 300

 aag caa cag ttt cct ttt cat tca gca cca gca ttg gat gtt gat tgg     1083
 Lys Gln Gln Phe Pro Phe His Ser Ala Pro Ala Leu Asp Val Asp Trp
                 305                 310                 315

 cag agc aac aac acc ttt gct tct tgt agt aca gat atg tgc att cat     1131
 Gln Ser Asn Asn Thr Phe Ala Ser Cys Ser Thr Asp Met Cys Ile His
             320                 325                 330

 gtc tgt aaa tta gga caa gac aga cct att aaa aca ttc caa gga cat     1179
 Val Cys Lys Leu Gly Gln Asp Arg Pro Ile Lys Thr Phe Gln Gly His
         335                 340                 345

 acg aat gaa gta aat gct atc aaa tgg gac cca act ggc aat ctc ttg     1227
 Thr Asn Glu Val Asn Ala Ile Lys Trp Asp Pro Thr Gly Asn Leu Leu
     350                 355                 360

 gcc tcc tgt tct gac gac atg act tta aag ata tgg agt atg aaa caa     1275
 Ala Ser Cys Ser Asp Asp Met Thr Leu Lys Ile Trp Ser Met Lys Gln
 365                 370                 375                 380

 gac aat tgt gtc cat gat ttg caa gca cat aat aaa gaa att tat act     1323
 Asp Asn Cys Val His Asp Leu Gln Ala His Asn Lys Glu Ile Tyr Thr
                 385                 390                 395

 atc aaa tgg agt cca aca gga cca ggg act aat aat cca aat gcc aac     1371
 Ile Lys Trp Ser Pro Thr Gly Pro Gly Thr Asn Asn Pro Asn Ala Asn
             400                 405                 410

 ctt atg tta gca agt gca tcc ttt gat tct act gtt agg tta tgg gat     1419
 Leu Met Leu Ala Ser Ala Ser Phe Asp Ser Thr Val Arg Leu Trp Asp
         415                 420                 425

 gta gac cga ggg ata tgc atc cat acc ttg aca aaa cac caa gag cct     1467
 Val Asp Arg Gly Ile Cys Ile His Thr Leu Thr Lys His Gln Glu Pro
     430                 435                 440

 gtg tac agt gta gct ttc agt cct gat ggc agg tat ctg gca agt ggt     1515
 Val Tyr Ser Val Ala Phe Ser Pro Asp Gly Arg Tyr Leu Ala Ser Gly
 445                 450                 455                 460

 tct ttt gac aaa tgt gta cac atc tgg aac acg cag aca ggt gct cta     1563
 Ser Phe Asp Lys Cys Val His Ile Trp Asn Thr Gln Thr Gly Ala Leu
                 465                 470                 475

 gtt cac agc tat agg gga aca ggt gga ata ttt gaa gtt tgc tgg aat     1611
 Val His Ser Tyr Arg Gly Thr Gly Gly Ile Phe Glu Val Cys Trp Asn
             480                 485                 490

 gca gca gga gac aaa gtt gga gcc agt gca tca gat ggt tca gtt tgt     1659
 Ala Ala Gly Asp Lys Val Gly Ala Ser Ala Ser Asp Gly Ser Val Cys
         495                 500                 505

 gta tta gac ctt cgg aaa tag cg ctactagttg gaagccatgg accgactatg     1712
 Val Leu Asp Leu Arg Lys 
     510

 aatgtgtaca tagccaaaat gactgtccct gacccatgta ctgctatagt cccacttgaa   1772

 ccatggccag tccactacag ccaaatctaa aagaaatata tacatacagt gtatataaac   1832

 aaaattgcac cctgaagatg acagagtttt gtcacagctt gtgaattctg ttcaccaagt   1892

 gctggaatct aatctgctgt gcccctaaaa tagcatttag aagttttgga tatgaaaaac   1952

 agaagagaga aaaatataca ttataaaagc aaaaaaaaaa aa                      1994




      <210> 112
      <211> 6222
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(5988)

      <400> 112
  atg ggt ctt ggc aaa act att caa tca att aca ttc ctc tat gaa atc      48
  Met Gly Leu Gly Lys Thr Ile Gln Ser Ile Thr Phe Leu Tyr Glu Ile
    1               5                  10                  15

 ctt ctg act ggt ata aga gga cct ttc ctg att att gct cca ctt tct       96
 Leu Leu Thr Gly Ile Arg Gly Pro Phe Leu Ile Ile Ala Pro Leu Ser
              20                  25                  30

 act att gca aac tgg gag aga gaa ttt cgt acg tgg act gat att aac      144
 Thr Ile Ala Asn Trp Glu Arg Glu Phe Arg Thr Trp Thr Asp Ile Asn
          35                  40                  45

 gtt gtg gtt tat cat ggg agc ctg att agc aga caa atg ata cag caa      192
 Val Val Val Tyr His Gly Ser Leu Ile Ser Arg Gln Met Ile Gln Gln
      50                  55                  60

 tac gag atg tac ttc agg gat tca cag ggg cgt atc att cga gga gct      240
 Tyr Glu Met Tyr Phe Arg Asp Ser Gln Gly Arg Ile Ile Arg Gly Ala
  65                  70                  75                  80

 tac aga ttc caa gcc atc atc acc act ttt gaa atg att ctt gga ggc      288
 Tyr Arg Phe Gln Ala Ile Ile Thr Thr Phe Glu Met Ile Leu Gly Gly
                  85                  90                  95

 tgt gga gag ctt aat gca att gaa tgg cga tgt gtg att att gat gaa      336
 Cys Gly Glu Leu Asn Ala Ile Glu Trp Arg Cys Val Ile Ile Asp Glu
             100                 105                 110

 gca cat agg tta aaa aat aaa aat tgt aaa ctc tta gag ggc ctg aaa      384
 Ala His Arg Leu Lys Asn Lys Asn Cys Lys Leu Leu Glu Gly Leu Lys
         115                 120                 125

 ctc atg aat ctg gaa cac aag gtg ctt ttg act ggc acc cct ctc caa      432
 Leu Met Asn Leu Glu His Lys Val Leu Leu Thr Gly Thr Pro Leu Gln
     130                 135                 140

 aat aca gtt gaa gaa cta ttt agt ctt ctt cac ttt ctt gaa ccc tta      480
 Asn Thr Val Glu Glu Leu Phe Ser Leu Leu His Phe Leu Glu Pro Leu
 145                 150                 155                 160

 agg ttt cct tct gaa tca aca ttt atg caa gaa ttt ggg gat ctg aaa      528
 Arg Phe Pro Ser Glu Ser Thr Phe Met Gln Glu Phe Gly Asp Leu Lys
                 165                 170                 175

 aca gag gaa cag gta cag aaa ctt cag gtt atc ctg aaa cca atg atg      576
 Thr Glu Glu Gln Val Gln Lys Leu Gln Val Ile Leu Lys Pro Met Met
             180                 185                 190

 ttg aga cga tta aaa gaa gat gtg gaa aag aag ttg gca cct aaa gaa      624
 Leu Arg Arg Leu Lys Glu Asp Val Glu Lys Lys Leu Ala Pro Lys Glu
         195                 200                 205

 gaa acc atc att gaa gta gaa ctt act aat att caa aag aaa tac tac      672
 Glu Thr Ile Ile Glu Val Glu Leu Thr Asn Ile Gln Lys Lys Tyr Tyr
     210                 215                 220

 cgg gct atc ttg gaa aag aac ttt tct ttt tta tcc aaa gga gca gga      720
 Arg Ala Ile Leu Glu Lys Asn Phe Ser Phe Leu Ser Lys Gly Ala Gly
 225                 230                 235                 240

 caa act aat gta cct aac ttg gtc aat acc atg atg gag ctc agg aaa      768
 Gln Thr Asn Val Pro Asn Leu Val Asn Thr Met Met Glu Leu Arg Lys
                 245                 250                 255

 tgt tgt aat cat cca tat ctt ata aaa ggt gct gag gag aaa ata ctt      816
 Cys Cys Asn His Pro Tyr Leu Ile Lys Gly Ala Glu Glu Lys Ile Leu
             260                 265                 270

 gga gaa ttt aga gat act tac aat cca gct gct tct gat ttt cat ctt      864
 Gly Glu Phe Arg Asp Thr Tyr Asn Pro Ala Ala Ser Asp Phe His Leu
         275                 280                 285

 caa gca atg atc cag tct gct ggt aaa ttg gtc ctt att gat aaa ttg      912
 Gln Ala Met Ile Gln Ser Ala Gly Lys Leu Val Leu Ile Asp Lys Leu
     290                 295                 300

 ctt ccc aaa atg aaa gcc gga ggt cat aaa gtg ctc atc ttc tct caa      960
 Leu Pro Lys Met Lys Ala Gly Gly His Lys Val Leu Ile Phe Ser Gln
 305                 310                 315                 320

 atg gtt cgt tgc ctt gac att ctg gag gac tat ctc ata cat aaa aga     1008
 Met Val Arg Cys Leu Asp Ile Leu Glu Asp Tyr Leu Ile His Lys Arg
                 325                 330                 335

 tac tta tat gag cga att gat ggc aga gtc aga gga aat ctt cgg caa     1056
 Tyr Leu Tyr Glu Arg Ile Asp Gly Arg Val Arg Gly Asn Leu Arg Gln
             340                 345                 350

 gct gct ata gat aga ttt agt aaa cct gat tca gat aga ttt gtt ttt     1104
 Ala Ala Ile Asp Arg Phe Ser Lys Pro Asp Ser Asp Arg Phe Val Phe
         355                 360                 365

 ctc ctg tgt acc cga gct ggt ggg ttg ggc atc aac tta act gca gct     1152
 Leu Leu Cys Thr Arg Ala Gly Gly Leu Gly Ile Asn Leu Thr Ala Ala
     370                 375                 380

 gat aca tgt ata att ttt gat tct gat tgg aat cct cag aat gat ctt     1200
 Asp Thr Cys Ile Ile Phe Asp Ser Asp Trp Asn Pro Gln Asn Asp Leu
 385                 390                 395                 400

 cag gcc caa gct cgt tgc cac aga att ggt cag aac aaa gca gtt aaa     1248
 Gln Ala Gln Ala Arg Cys His Arg Ile Gly Gln Asn Lys Ala Val Lys
                 405                 410                 415

 gtc tac aga ctg gta act cgt aac tca tat gag aga gag atg ttt gac     1296
 Val Tyr Arg Leu Val Thr Arg Asn Ser Tyr Glu Arg Glu Met Phe Asp
             420                 425                 430

 cga gcc agt ttg aaa ctg ggc cta gat aaa gct gtg tta cag agc atg     1344
 Arg Ala Ser Leu Lys Leu Gly Leu Asp Lys Ala Val Leu Gln Ser Met
         435                 440                 445

 agt gga aga gaa agt aat gtt ggt ggt att cag cag ctt tcc aaa aag     1392
 Ser Gly Arg Glu Ser Asn Val Gly Gly Ile Gln Gln Leu Ser Lys Lys
     450                 455                 460

 gaa ata gaa gat ctg ctt cga aga ggt gct tat ggt gct att atg gag     1440
 Glu Ile Glu Asp Leu Leu Arg Arg Gly Ala Tyr Gly Ala Ile Met Glu
 465                 470                 475                 480

 gaa gaa gat gaa ggc tct aaa ttc tgc gaa gag gat atc gat cag att     1488
 Glu Glu Asp Glu Gly Ser Lys Phe Cys Glu Glu Asp Ile Asp Gln Ile
                 485                 490                 495

 tta cta cgt cgt aca aaa act att aca att gaa tca gaa gga cgt ggg     1536
 Leu Leu Arg Arg Thr Lys Thr Ile Thr Ile Glu Ser Glu Gly Arg Gly
             500                 505                 510

 tca aca ttt gcc aag gcg agt ttt gtg gca tct gga aac cgg aca gat     1584
 Ser Thr Phe Ala Lys Ala Ser Phe Val Ala Ser Gly Asn Arg Thr Asp
         515                 520                 525

 att tct tta gat gat ccc aac ttc tgg caa aaa tgg gct aaa aag gca     1632
 Ile Ser Leu Asp Asp Pro Asn Phe Trp Gln Lys Trp Ala Lys Lys Ala
     530                 535                 540

 gaa ata gat ata gag gcc atc agt ggc aga aac agc ttg gtt att gac     1680
 Glu Ile Asp Ile Glu Ala Ile Ser Gly Arg Asn Ser Leu Val Ile Asp
 545                 550                 555                 560

 act cca aga att agg aag caa aca aga cct ttt agt gcc aca aaa gat     1728
 Thr Pro Arg Ile Arg Lys Gln Thr Arg Pro Phe Ser Ala Thr Lys Asp
                 565                 570                 575

 gaa ttg gct gaa tta tct gaa gct gaa agt gaa gga gat gaa aag ccc     1776
 Glu Leu Ala Glu Leu Ser Glu Ala Glu Ser Glu Gly Asp Glu Lys Pro
             580                 585                 590

 aaa ctc cgg aga ccc tgt gac cgt tcc aat ggc tat gga aga act gaa     1824
 Lys Leu Arg Arg Pro Cys Asp Arg Ser Asn Gly Tyr Gly Arg Thr Glu
         595                 600                 605

 tgc ttt aga gtt gag aaa aac ctg cta gtt tat ggg tgg ggc cga tgg     1872
 Cys Phe Arg Val Glu Lys Asn Leu Leu Val Tyr Gly Trp Gly Arg Trp
     610                 615                 620

 aga gag att cta tct cat ggc cgt ttc aaa agg cag cta aat gaa cac     1920
 Arg Glu Ile Leu Ser His Gly Arg Phe Lys Arg Gln Leu Asn Glu His
 625                 630                 635                 640

 gat gta gag ata att tgc cga gct ctc tta gca tat tgc ctt gtt cac     1968
 Asp Val Glu Ile Ile Cys Arg Ala Leu Leu Ala Tyr Cys Leu Val His
                 645                 650                 655

 tac cga gga gat gag aag att aaa ggt ttc ata tgg gat ctc att act     2016
 Tyr Arg Gly Asp Glu Lys Ile Lys Gly Phe Ile Trp Asp Leu Ile Thr
             660                 665                 670

 cca act gaa gat gga cag aca cga gag cta cag aat cat cta ggc cta     2064
 Pro Thr Glu Asp Gly Gln Thr Arg Glu Leu Gln Asn His Leu Gly Leu
         675                 680                 685

 tca gct cct gta ccc agg ggt cga aaa ggg aag aaa gta aaa act caa     2112
 Ser Ala Pro Val Pro Arg Gly Arg Lys Gly Lys Lys Val Lys Thr Gln
     690                 695                 700

 aca agc tca ttt gat ata caa aaa gca gaa tgg ctt cga aaa tat aat     2160
 Thr Ser Ser Phe Asp Ile Gln Lys Ala Glu Trp Leu Arg Lys Tyr Asn
 705                 710                 715                 720

 ccc gag cag ctc ctt caa gat gaa ggc tac aaa aaa caa aaa aaa cac     2208
 Pro Glu Gln Leu Leu Gln Asp Glu Gly Tyr Lys Lys Gln Lys Lys His
                 725                 730                 735

 cac tgt aat aag gtt ttg ctt cgt gtg aga atg ctg tat tat cta aag     2256
 His Cys Asn Lys Val Leu Leu Arg Val Arg Met Leu Tyr Tyr Leu Lys
             740                 745                 750

 caa gaa gtt att gga aat gag tgt cag aaa gta ttt gat gga gtt gat     2304
 Gln Glu Val Ile Gly Asn Glu Cys Gln Lys Val Phe Asp Gly Val Asp
         755                 760                 765

 gca agt gac att gat gtt tgg gta cca gaa cca gac cac tca gaa gtt     2352
 Ala Ser Asp Ile Asp Val Trp Val Pro Glu Pro Asp His Ser Glu Val
     770                 775                 780

 cct gct gag tgg tgg gat ttt gat gct gat aag tca ctc ctt att gga     2400
 Pro Ala Glu Trp Trp Asp Phe Asp Ala Asp Lys Ser Leu Leu Ile Gly
 785                 790                 795                 800

 gtt ttt aaa cat gga tat gaa aaa tat aac act att cga gca gac cca     2448
 Val Phe Lys His Gly Tyr Glu Lys Tyr Asn Thr Ile Arg Ala Asp Pro
                 805                 810                 815

 gca tta tgc ttc ttg gaa aga gtg gga aaa cct gat gag aaa gca gtt     2496
 Ala Leu Cys Phe Leu Glu Arg Val Gly Lys Pro Asp Glu Lys Ala Val
             820                 825                 830

 gct gct gaa cag aga gcg aat gat tat atg gat ggg gat gtg gaa gat     2544
 Ala Ala Glu Gln Arg Ala Asn Asp Tyr Met Asp Gly Asp Val Glu Asp
         835                 840                 845

 cca gaa tac aaa cct gcc cca gcc atc ttt aaa gat gat ata gag gat     2592
 Pro Glu Tyr Lys Pro Ala Pro Ala Ile Phe Lys Asp Asp Ile Glu Asp
     850                 855                 860

 gat gtt tcc tca cca gga gat ctt gtt ata gca gat gga gat ggt caa     2640
 Asp Val Ser Ser Pro Gly Asp Leu Val Ile Ala Asp Gly Asp Gly Gln
 865                 870                 875                 880

 ctg atg gag ggt gat aaa gta tat tgg cct act caa tca gct tta acc     2688
 Leu Met Glu Gly Asp Lys Val Tyr Trp Pro Thr Gln Ser Ala Leu Thr
                 885                 890                 895

 aca cgt ttg agg cgt ctc atc act gca tac cag cgt act aat aaa aac     2736
 Thr Arg Leu Arg Arg Leu Ile Thr Ala Tyr Gln Arg Thr Asn Lys Asn
             900                 905                 910

 aga caa att cag cag ata caa ccg act ttc tcg gtg cct acc agt gta     2784
 Arg Gln Ile Gln Gln Ile Gln Pro Thr Phe Ser Val Pro Thr Ser Val
         915                 920                 925

 atg cag cct att tat gag gaa gcc act ctt aat cct aaa atg gca gcc     2832
 Met Gln Pro Ile Tyr Glu Glu Ala Thr Leu Asn Pro Lys Met Ala Ala
     930                 935                 940

 aag ata gaa aga cag caa aga tgg aca aga aga gaa gaa gct gac ttt     2880
 Lys Ile Glu Arg Gln Gln Arg Trp Thr Arg Arg Glu Glu Ala Asp Phe
 945                 950                 955                 960

 tat agg gtt gta tct aca ttt gga gtg gtt ttt gac cct gac aga ggc     2928
 Tyr Arg Val Val Ser Thr Phe Gly Val Val Phe Asp Pro Asp Arg Gly
                 965                 970                 975

 caa ttt gat tgg aca aaa ttt aga gct atg gct agg cta cat aag aaa     2976
 Gln Phe Asp Trp Thr Lys Phe Arg Ala Met Ala Arg Leu His Lys Lys
             980                 985                 990

 act gat gat agt ttg gaa aaa tat ttg tac gca ttc atg tcc atg tgt     3024
 Thr Asp Asp Ser Leu Glu Lys Tyr Leu Tyr Ala Phe Met Ser Met Cys
         995                1000                1005

 cgg agg gtt tgt cgt ctt cct tcc aaa gaa gaa ttg gtg gat cca aat     3072
 Arg Arg Val Cys Arg Leu Pro Ser Lys Glu Glu Leu Val Asp Pro Asn
    1010                1015                1020

 att ttt atc cag ccc atc aca gaa gaa cgt gct tct agg act ttg tat     3120
 Ile Phe Ile Gln Pro Ile Thr Glu Glu Arg Ala Ser Arg Thr Leu Tyr
1025                1030                1035                1040

 cgc att gaa ctt cta agg aaa gta cgg gaa cag gcc ctt cga cat cca     3168
 Arg Ile Glu Leu Leu Arg Lys Val Arg Glu Gln Ala Leu Arg His Pro
                1045                1050                1055

 cag ttg ttt gaa cgc ttg aag ctt tgc cat cca aat cca gat tta cca     3216
 Gln Leu Phe Glu Arg Leu Lys Leu Cys His Pro Asn Pro Asp Leu Pro
            1060                1065                1070

 gtc tgg tgg gaa tgt ggc cct cat gat agg gat ttg ctt att ggt gct     3264
 Val Trp Trp Glu Cys Gly Pro His Asp Arg Asp Leu Leu Ile Gly Ala
        1075                1080                1085

 gcc aaa cac ggg gtg agc cga aca gac tat cac att ctt cgt gat cct     3312
 Ala Lys His Gly Val Ser Arg Thr Asp Tyr His Ile Leu Arg Asp Pro
    1090                1095                1100

 gaa ctc tca ttt atg gca gct cag agg aac tac agt caa agt aag atg     3360
 Glu Leu Ser Phe Met Ala Ala Gln Arg Asn Tyr Ser Gln Ser Lys Met
1105                1110                1115                1120

 gct cat tca agg act tct acc cca ctt cta cag caa tat caa gta gca     3408
 Ala His Ser Arg Thr Ser Thr Pro Leu Leu Gln Gln Tyr Gln Val Ala
                1125                1130                1135

 ctt tct gct tct cct ctt acc tct cta cct agg ctc cta gat gct aaa     3456
 Leu Ser Ala Ser Pro Leu Thr Ser Leu Pro Arg Leu Leu Asp Ala Lys
            1140                1145                1150

 ggt att att cta gag gag atg aaa gtt aaa agt gaa aac ctt aaa gag     3504
 Gly Ile Ile Leu Glu Glu Met Lys Val Lys Ser Glu Asn Leu Lys Glu
        1155                1160                1165

 gag cct cag tct tct gaa gaa gaa tct atg tct tct gtg gaa acc agg     3552
 Glu Pro Gln Ser Ser Glu Glu Glu Ser Met Ser Ser Val Glu Thr Arg
    1170                1175                1180

 aca ctg ata aaa tct gag cct gta agt cca aag aat ggt gtt tta cca     3600
 Thr Leu Ile Lys Ser Glu Pro Val Ser Pro Lys Asn Gly Val Leu Pro
1185                1190                1195                1200

 cag gct act gga gac cag aaa tct ggt gga aaa tgt gaa aca gac aga     3648
 Gln Ala Thr Gly Asp Gln Lys Ser Gly Gly Lys Cys Glu Thr Asp Arg
                1205                1210                1215

 cgc atg gtt gca gcc aga aca gaa ccc cta act cca aac cca gct tct     3696
 Arg Met Val Ala Ala Arg Thr Glu Pro Leu Thr Pro Asn Pro Ala Ser
            1220                1225                1230

 aag aaa cca aga gtc cac aaa agg gga tca gaa tct agt tct gat tct     3744
 Lys Lys Pro Arg Val His Lys Arg Gly Ser Glu Ser Ser Ser Asp Ser
        1235                1240                1245

 gac tca gat tct gag aga tca tct tgt tct tcc aga tca tct tct tcc     3792
 Asp Ser Asp Ser Glu Arg Ser Ser Cys Ser Ser Arg Ser Ser Ser Ser
    1250                1255                1260

 tca tca tcc tct tct tgc tcc cac tct cga tca ggc tct agt tct tct     3840
 Ser Ser Ser Ser Ser Cys Ser His Ser Arg Ser Gly Ser Ser Ser Ser
1265                1270                1275                1280

 tca tct tca tct tgt tct tca gca tct tct tca tcc tct tcc tcc acc     3888
 Ser Ser Ser Ser Cys Ser Ser Ala Ser Ser Ser Ser Ser Ser Ser Thr
                1285                1290                1295

 tct tcc tcc tcc tcc tcc tct tca tct tca tca gaa gaa agt gac agt     3936
 Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Ser Glu Glu Ser Asp Ser
            1300                1305                1310

 gat gaa gaa gaa gcc caa aaa cga gaa agt act act cac atg aaa gcc     3984
 Asp Glu Glu Glu Ala Gln Lys Arg Glu Ser Thr Thr His Met Lys Ala
        1315                1320                1325

 tat gat gaa gaa agc gtc gcg tca ctg agc act acc cag gat gag act     4032
 Tyr Asp Glu Glu Ser Val Ala Ser Leu Ser Thr Thr Gln Asp Glu Thr
    1330                1335                1340

 cag gat agt ttt cag atg aac aat ggg aca cca gag tct gct tat atc     4080
 Gln Asp Ser Phe Gln Met Asn Asn Gly Thr Pro Glu Ser Ala Tyr Ile
1345                1350                1355                1360

 tta caa ggt gga tat atg ctg gca gcc tcg tat tgg cca aag gat cgt     4128
 Leu Gln Gly Gly Tyr Met Leu Ala Ala Ser Tyr Trp Pro Lys Asp Arg
                1365                1370                1375

 gtg atg atc aat agg ttg gac agt att tgt caa aca gtt ctg aaa gga     4176
 Val Met Ile Asn Arg Leu Asp Ser Ile Cys Gln Thr Val Leu Lys Gly
            1380                1385                1390

 aag tgg cct tca gct aga aga agt tat gat gct aac aca gtg gct tct     4224
 Lys Trp Pro Ser Ala Arg Arg Ser Tyr Asp Ala Asn Thr Val Ala Ser
        1395                1400                1405

 ttc tat acc aca aaa ctg ctg gac agc cct gga gca gct aca gaa tac     4272
 Phe Tyr Thr Thr Lys Leu Leu Asp Ser Pro Gly Ala Ala Thr Glu Tyr
    1410                1415                1420

 agc gag ccc agt gta ccc act ccc cca ggt gcc ggt gtt aaa gaa gaa     4320
 Ser Glu Pro Ser Val Pro Thr Pro Pro Gly Ala Gly Val Lys Glu Glu
1425                1430                1435                1440

 cat gat cag tca aca cag atg tca aag gaa ggt ggt ttg aag ttg aca     4368
 His Asp Gln Ser Thr Gln Met Ser Lys Glu Gly Gly Leu Lys Leu Thr
                1445                1450                1455

 ttt cag aag caa ggg ctt gct cag aaa aga cca ttt gat ggt gaa gac     4416
 Phe Gln Lys Gln Gly Leu Ala Gln Lys Arg Pro Phe Asp Gly Glu Asp
            1460                1465                1470

 ggt gct ctg ggg cag cag cag tac ctc act cgg ctt cga gag ctt caa     4464
 Gly Ala Leu Gly Gln Gln Gln Tyr Leu Thr Arg Leu Arg Glu Leu Gln
        1475                1480                1485

 agt gca tca gag acc agc ctc gtc aat ttc cca aaa tcc ata cca gta     4512
 Ser Ala Ser Glu Thr Ser Leu Val Asn Phe Pro Lys Ser Ile Pro Val
    1490                1495                1500

 tca ggt act tcc att caa cca acc ctt ggt gcc aat ggt gtg ata tta     4560
 Ser Gly Thr Ser Ile Gln Pro Thr Leu Gly Ala Asn Gly Val Ile Leu
1505                1510                1515                1520

 gac aac cag cct ata gtc aaa aaa agg cga gga agg agg aag aat gta     4608
 Asp Asn Gln Pro Ile Val Lys Lys Arg Arg Gly Arg Arg Lys Asn Val
                1525                1530                1535

 gaa ggt gtt gac atc ttc ttt ttt aac aga aat aaa cca cct aat cat     4656
 Glu Gly Val Asp Ile Phe Phe Phe Asn Arg Asn Lys Pro Pro Asn His
            1540                1545                1550

 gtt tct tta ggc tta acc tcc tca cag att tcc aca ggg ata aat cca     4704
 Val Ser Leu Gly Leu Thr Ser Ser Gln Ile Ser Thr Gly Ile Asn Pro
        1555                1560                1565

 gca cta tcc tat act caa cct caa gga att cct gat aca gaa agt cca     4752
 Ala Leu Ser Tyr Thr Gln Pro Gln Gly Ile Pro Asp Thr Glu Ser Pro
    1570                1575                1580

 gtt cca gtt att aat ctt aaa gat gga acg aga ctt gca gga gat gat     4800
 Val Pro Val Ile Asn Leu Lys Asp Gly Thr Arg Leu Ala Gly Asp Asp
1585                1590                1595                1600

 gca cca aag aga aag gat ttg gaa aaa tgg ctt aag gag cac ccg ggt     4848
 Ala Pro Lys Arg Lys Asp Leu Glu Lys Trp Leu Lys Glu His Pro Gly
                1605                1610                1615

 tat gtg gaa gat ttg gga gct ttt att cct aga atg cag ctt cat gag     4896
 Tyr Val Glu Asp Leu Gly Ala Phe Ile Pro Arg Met Gln Leu His Glu
            1620                1625                1630

 gga aga ccc aaa caa aaa aga cac cgt tgc aga aac ccc aat aaa cta     4944
 Gly Arg Pro Lys Gln Lys Arg His Arg Cys Arg Asn Pro Asn Lys Leu
        1635                1640                1645

 gat gtg aat agt ctc act gga gaa gaa cgt gtt caa ctg att aac aga     4992
 Asp Val Asn Ser Leu Thr Gly Glu Glu Arg Val Gln Leu Ile Asn Arg
    1650                1655                1660

 aga aat gct aga aag gtt gga ggt gca ttt gct ccc cct ttg aaa gat     5040
 Arg Asn Ala Arg Lys Val Gly Gly Ala Phe Ala Pro Pro Leu Lys Asp
1665                1670                1675                1680

 tta tgt aga ttc cta aaa gaa aat tca gaa tat gga gta gct cct gaa     5088
 Leu Cys Arg Phe Leu Lys Glu Asn Ser Glu Tyr Gly Val Ala Pro Glu
                1685                1690                1695

 tgg gga gat gtt gtt aag caa tct gga ttt ctt cca gaa agc atg tat     5136
 Trp Gly Asp Val Val Lys Gln Ser Gly Phe Leu Pro Glu Ser Met Tyr
            1700                1705                1710

 gaa cgt att ctc act ggt ccc gtt gtg aga gag gaa gta agc agg cgg     5184
 Glu Arg Ile Leu Thr Gly Pro Val Val Arg Glu Glu Val Ser Arg Arg
        1715                1720                1725

 ggg aga cgg cct aaa agt gga att gca aag gcc aca gca gca gca gct     5232
 Gly Arg Arg Pro Lys Ser Gly Ile Ala Lys Ala Thr Ala Ala Ala Ala
    1730                1735                1740

 gct gca tct gcc acc agt gtt tca ggc aat cct ttg tta gcc aat gga     5280
 Ala Ala Ser Ala Thr Ser Val Ser Gly Asn Pro Leu Leu Ala Asn Gly
1745                1750                1755                1760

 cta ctt cca ggt gtg gat ctc aca act ctt cag gcc tta caa caa aac     5328
 Leu Leu Pro Gly Val Asp Leu Thr Thr Leu Gln Ala Leu Gln Gln Asn
                1765                1770                1775

 cta caa aac ttg cag tca ctg caa gta act gct ggg ttg atg gga atg     5376
 Leu Gln Asn Leu Gln Ser Leu Gln Val Thr Ala Gly Leu Met Gly Met
            1780                1785                1790

 cct acc ggc ctt cct tct gga gga gaa gct aaa aac atg gct gct atg     5424
 Pro Thr Gly Leu Pro Ser Gly Gly Glu Ala Lys Asn Met Ala Ala Met
        1795                1800                1805

 ttc ccc atg ctg ctg tca gga atg gct gga tta cca aat ctg ttg ggc     5472
 Phe Pro Met Leu Leu Ser Gly Met Ala Gly Leu Pro Asn Leu Leu Gly
    1810                1815                1820

 atg gga gga ctc ctg aca aag cct acg gaa tct ggg aca gaa gac aaa     5520
 Met Gly Gly Leu Leu Thr Lys Pro Thr Glu Ser Gly Thr Glu Asp Lys
1825                1830                1835                1840

 aag gga agt gac tct aag gag tca gaa gga aaa aca gaa agg aca gag     5568
 Lys Gly Ser Asp Ser Lys Glu Ser Glu Gly Lys Thr Glu Arg Thr Glu
                1845                1850                1855

 agc caa agt tca gag aat ggt gga gaa aac tct gtg tca agt tct cct     5616
 Ser Gln Ser Ser Glu Asn Gly Gly Glu Asn Ser Val Ser Ser Ser Pro
            1860                1865                1870

 tcc gca tcc tct act gct gca tta aat aca gct gca gct gcc aac cca     5664
 Ser Ala Ser Ser Thr Ala Ala Leu Asn Thr Ala Ala Ala Ala Asn Pro
        1875                1880                1885

 tta gct ctt aac cca cta tta cta tct aat ata ctt tat cca ggg atg     5712
 Leu Ala Leu Asn Pro Leu Leu Leu Ser Asn Ile Leu Tyr Pro Gly Met
    1890                1895                1900

 ctt ctc act cca ggc ctt aat ctt cat att cca act ttg tcc cag tcc     5760
 Leu Leu Thr Pro Gly Leu Asn Leu His Ile Pro Thr Leu Ser Gln Ser
1905                1910                1915                1920

 aat act ttt gat gta caa aac aaa aac agt gac tta ggc tcg tct aag     5808
 Asn Thr Phe Asp Val Gln Asn Lys Asn Ser Asp Leu Gly Ser Ser Lys
                1925                1930                1935

 tct gta gaa gta aaa gaa gaa gat tcc aga att aaa gat cag gaa gac     5856
 Ser Val Glu Val Lys Glu Glu Asp Ser Arg Ile Lys Asp Gln Glu Asp
            1940                1945                1950

 aaa gga gga act gaa cca agt cct ctc aat gaa aac agc aca gat gag     5904
 Lys Gly Gly Thr Glu Pro Ser Pro Leu Asn Glu Asn Ser Thr Asp Glu
        1955                1960                1965

 ggt tca gag aaa gct gat gct tca tct gga tct gat agt aca tcg tcg     5952
 Gly Ser Glu Lys Ala Asp Ala Ser Ser Gly Ser Asp Ser Thr Ser Ser
    1970                1975                1980

 tca tct gag gat tca gat tct agt aat gaa gac tga ttcc cagactctgc     6002
 Ser Ser Glu Asp Ser Asp Ser Ser Asn Glu Asp 
1985                1990                1995

 acttaaaata tgaactgatt ttggattttt tctttaataa ttaattgtaa ataccccagt   6062

 gttgagtgca tcaataactt actgaccgaa catttcagtt atttgtttag aagtgcaaac   6122

 tgctttcaga gactttttgc atgtaatatt tcttaagatt cataagtttc tgaactcgta   6182

 tgtactatca aatacataaa ggtgtaaaat taaaaaaaaa                         6222




      <210> 113
      <211> 1673
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (14)..(1342)

      <400> 113
 ggcccggccc acg   atg act tgc tac cga ggc ttc ttg ctg ggc agc tgt      49
                  Met Thr Cys Tyr Arg Gly Phe Leu Leu Gly Ser Cys
                    1               5                  10

 tgt cgc gtg gcg ggc ggc cgg gcg gcg gcg ctg cgg gga ccg ggt gcg       97
 Cys Arg Val Ala Gly Gly Arg Ala Ala Ala Leu Arg Gly Pro Gly Ala
          15                  20                  25

 gga ggc ccc gcc gcg cgg ccc cgg ctg ggc ggt gac ggt ggc ggc cgg      145
 Gly Gly Pro Ala Ala Arg Pro Arg Leu Gly Gly Asp Gly Gly Gly Arg
      30                  35                  40

 cgg cac ctg ggg cag ggg cag ccg cgc gag ctg gcg ggc tgt ggc agc      193
 Arg His Leu Gly Gln Gly Gln Pro Arg Glu Leu Ala Gly Cys Gly Ser
  45                  50                  55                  60

 cgc gcg gac ggc ggc ttc cgc ccc tcc cgg gtg gtg gtg gtg gcc aaa      241
 Arg Ala Asp Gly Gly Phe Arg Pro Ser Arg Val Val Val Val Ala Lys
                  65                  70                  75

 acc acc cgg tac gag ttc gag cag cag cgg tac cgt tac gcg gag ctc      289
 Thr Thr Arg Tyr Glu Phe Glu Gln Gln Arg Tyr Arg Tyr Ala Glu Leu
              80                  85                  90

 tcg gag gag gac ctg aag cag ctg ctt gca ttg aaa ggc tct agt tac      337
 Ser Glu Glu Asp Leu Lys Gln Leu Leu Ala Leu Lys Gly Ser Ser Tyr
          95                 100                 105

 agt gga ctt ctt gaa cga cat cat att cac acc aaa aat gta gaa cat      385
 Ser Gly Leu Leu Glu Arg His His Ile His Thr Lys Asn Val Glu His
     110                 115                 120

 att ata gat agt tta cgg aat gag gga att gag gtt cgt cta gta aag      433
 Ile Ile Asp Ser Leu Arg Asn Glu Gly Ile Glu Val Arg Leu Val Lys
 125                 130                 135                 140

 agg aga gaa tat gat gaa gag act gtt cga tgg gca gat gct gtc ata      481
 Arg Arg Glu Tyr Asp Glu Glu Thr Val Arg Trp Ala Asp Ala Val Ile
                 145                 150                 155

 gct gca gga ggt gat ggc aca atg ctg ctg gca gcg agt aaa gtc ttg      529
 Ala Ala Gly Gly Asp Gly Thr Met Leu Leu Ala Ala Ser Lys Val Leu
             160                 165                 170

 gac aga ctt aaa cca gtt ata ggg gta aac act gat cca gaa cgg tct      577
 Asp Arg Leu Lys Pro Val Ile Gly Val Asn Thr Asp Pro Glu Arg Ser
         175                 180                 185

 gag ggt cat tta tgc ctg ccc gtt cga tat aca cat tcc ttt cca gaa      625
 Glu Gly His Leu Cys Leu Pro Val Arg Tyr Thr His Ser Phe Pro Glu
     190                 195                 200

 gcc tta cag aag ttc tat cgt ggt gag ttc agg tgg ttg tgg agg cag      673
 Ala Leu Gln Lys Phe Tyr Arg Gly Glu Phe Arg Trp Leu Trp Arg Gln
 205                 210                 215                 220

 aga atc agg tta tac ctt gaa ggg act ggc ata aac cct gta cct gtg      721
 Arg Ile Arg Leu Tyr Leu Glu Gly Thr Gly Ile Asn Pro Val Pro Val
                 225                 230                 235

 gac ctt cac gag cag cag cta agc ttg aat cag cac aat aga gcc ctt      769
 Asp Leu His Glu Gln Gln Leu Ser Leu Asn Gln His Asn Arg Ala Leu
             240                 245                 250

 aac att gaa aga gct cat gat gaa agg tct gag gct tca gga ccc caa      817
 Asn Ile Glu Arg Ala His Asp Glu Arg Ser Glu Ala Ser Gly Pro Gln
         255                 260                 265

 ctt ctg cca gtg aga gca cta aat gaa gtc ttc att ggg gag agt ctg      865
 Leu Leu Pro Val Arg Ala Leu Asn Glu Val Phe Ile Gly Glu Ser Leu
     270                 275                 280

 tca tcc agg gct tcc tac tat gag att tca gtt gat gat ggt cca tgg      913
 Ser Ser Arg Ala Ser Tyr Tyr Glu Ile Ser Val Asp Asp Gly Pro Trp
 285                 290                 295                 300

 gaa aaa cag aag agt tca ggg ctc aat ttg tgt act gga aca gga tca      961
 Glu Lys Gln Lys Ser Ser Gly Leu Asn Leu Cys Thr Gly Thr Gly Ser
                 305                 310                 315

 aag gcc tgg tca ttc aat att aac agg gtt gca act cag gct gta gaa     1009
 Lys Ala Trp Ser Phe Asn Ile Asn Arg Val Ala Thr Gln Ala Val Glu
             320                 325                 330

 gat gtt tta aat att gca aaa cga caa gga aat ttg agt ctt cca ttg     1057
 Asp Val Leu Asn Ile Ala Lys Arg Gln Gly Asn Leu Ser Leu Pro Leu
         335                 340                 345

 aac aga gaa ttg gta gag aaa gta aca aat gaa tat aat gaa tca ctg     1105
 Asn Arg Glu Leu Val Glu Lys Val Thr Asn Glu Tyr Asn Glu Ser Leu
     350                 355                 360

 ctc tac agt ccg gaa gaa cca aaa ata ctt ttc agt att cga gaa cca     1153
 Leu Tyr Ser Pro Glu Glu Pro Lys Ile Leu Phe Ser Ile Arg Glu Pro
 365                 370                 375                 380

 ata gca aat aga gtt ttc tca agc agt cgt cag cgt tgt ttc tcc tca     1201
 Ile Ala Asn Arg Val Phe Ser Ser Ser Arg Gln Arg Cys Phe Ser Ser
                 385                 390                 395

 aag gtt tgt gtt cgt tct cgt tgt tgg gat gcc tgt atg gtt gtg gat     1249
 Lys Val Cys Val Arg Ser Arg Cys Trp Asp Ala Cys Met Val Val Asp
             400                 405                 410

 gga gga act tct ttt gag ttt aat gat ggt gca att gct tcg atg atg     1297
 Gly Gly Thr Ser Phe Glu Phe Asn Asp Gly Ala Ile Ala Ser Met Met
         415                 420                 425

 atc aat aaa gaa gat gag ctt cga act gtg ctt ctt gaa cag tga agg     1345
 Ile Asn Lys Glu Asp Glu Leu Arg Thr Val Leu Leu Glu Gln 
     430                 435                 440

 atttcctcat gacaaatttt gattactggc gagaatattt ttacttcaga aacagactac   1405

 cagtcgtaaa gtgacatttt ttggttattg ttgagactgc ttgcccgtgg gctcagaagt   1465

 gagatttgca ttattcttct gttggattct gatagaaaaa aagacattca ctgtataaga   1525

 aaatggatgg actgaaccaa ttagaattga taccagtgaa atttttatat tgcttacaat   1585

 tggtaaccaa gagtgctgat acctttttaa atttagaggg gcaggcttaa ataaaggact   1645

 aaatatttag gatttgaaaa aaaaaaaa                                      1673




      <210> 114
      <211> 3042
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(2467)

      <400> 114
 aatcgtggct gactcttcct gcctccggtt cttgcctccc agtgcc   atg cag gtg      55
                                                      Met Gln Val
                                                        1

 cag gat gca acc agg cgg ccc tca gcc gtg cgc ttc ctc agc tcc ttt      103
 Gln Asp Ala Thr Arg Arg Pro Ser Ala Val Arg Phe Leu Ser Ser Phe
       5                  10                  15

 ctc cag ggc cgc cgg cac tcc acc tca gac cca gta ctg cgg ctg cag      151
 Leu Gln Gly Arg Arg His Ser Thr Ser Asp Pro Val Leu Arg Leu Gln
  20                  25                  30                  35

 cag gcc cgg cgg ggc tct ggc ttg ggc tcc ggc tct gcc acg aag ctg      199
 Gln Ala Arg Arg Gly Ser Gly Leu Gly Ser Gly Ser Ala Thr Lys Leu
                  40                  45                  50

 ctg tcc tcg tcc tct ctc cag gtg atg gtg gct gtt tcc tca gtc agc      247
 Leu Ser Ser Ser Ser Leu Gln Val Met Val Ala Val Ser Ser Val Ser
              55                  60                  65

 cat gca gag gga aac cca act ttc ccc gaa aga aaa aga aat tta gaa      295
 His Ala Glu Gly Asn Pro Thr Phe Pro Glu Arg Lys Arg Asn Leu Glu
          70                  75                  80

 cgt cca aca cca aag tac aca aaa gta ggg gag cgt tta cgg cat gtc      343
 Arg Pro Thr Pro Lys Tyr Thr Lys Val Gly Glu Arg Leu Arg His Val
      85                  90                  95

 att cct gga cac atg gca tgt tcc atg gcg tgt ggc ggt aga gct tgc      391
 Ile Pro Gly His Met Ala Cys Ser Met Ala Cys Gly Gly Arg Ala Cys
 100                 105                 110                 115

 aag tat gag aac cca gcc cgc tgg agt gag cag gag caa gcc att aag      439
 Lys Tyr Glu Asn Pro Ala Arg Trp Ser Glu Gln Glu Gln Ala Ile Lys
                 120                 125                 130

 ggg gtt tac tca tcc tgg gtc act gat aat ata ctg gcc atg gcc cgc      487
 Gly Val Tyr Ser Ser Trp Val Thr Asp Asn Ile Leu Ala Met Ala Arg
             135                 140                 145

 cca tcc tct gag ctc ctg gag aag tac cac atc att gat cag ttc ctc      535
 Pro Ser Ser Glu Leu Leu Glu Lys Tyr His Ile Ile Asp Gln Phe Leu
         150                 155                 160

 agc cat ggc ata aaa aca ata atc aac ctc cag cgc cct ggt gag cat      583
 Ser His Gly Ile Lys Thr Ile Ile Asn Leu Gln Arg Pro Gly Glu His
     165                 170                 175

 gct agc tgt ggg aac cct ctg gaa caa gaa agt ggc ttc aca tac ctt      631
 Ala Ser Cys Gly Asn Pro Leu Glu Gln Glu Ser Gly Phe Thr Tyr Leu
 180                 185                 190                 195

 cct gag gct ttc atg gag gct ggc att tac ttc tac aat ttc gga tgg      679
 Pro Glu Ala Phe Met Glu Ala Gly Ile Tyr Phe Tyr Asn Phe Gly Trp
                 200                 205                 210

 aag gat tat ggt gta gcg tct ctt act act atc cta gat atg gtg aag      727
 Lys Asp Tyr Gly Val Ala Ser Leu Thr Thr Ile Leu Asp Met Val Lys
             215                 220                 225

 gtg atg aca ttt gcc tta cag gaa gga aaa gta gct atc cat tgt cat      775
 Val Met Thr Phe Ala Leu Gln Glu Gly Lys Val Ala Ile His Cys His
         230                 235                 240

 gca ggg ctt ggt cga aca ggt gtt tta ata gcc tgt tac tta gtt ttt      823
 Ala Gly Leu Gly Arg Thr Gly Val Leu Ile Ala Cys Tyr Leu Val Phe
     245                 250                 255

 gca acg aga atg act gct gac caa gca att ata ttt gtg cgg gca aag      871
 Ala Thr Arg Met Thr Ala Asp Gln Ala Ile Ile Phe Val Arg Ala Lys
 260                 265                 270                 275

 cga ccc aat tcc ata caa acc aga gga cag ctc ctc tgt gta agg gaa      919
 Arg Pro Asn Ser Ile Gln Thr Arg Gly Gln Leu Leu Cys Val Arg Glu
                 280                 285                 290

 ttt act cag ttt cta act cct ctc cgc aat ata ttc tct tgc tgt gat      967
 Phe Thr Gln Phe Leu Thr Pro Leu Arg Asn Ile Phe Ser Cys Cys Asp
             295                 300                 305

 ccc aaa gca cat gct gtc acc tta cct caa tat cta att cgc cag cgt     1015
 Pro Lys Ala His Ala Val Thr Leu Pro Gln Tyr Leu Ile Arg Gln Arg
         310                 315                 320

 cat ctg ctt cat ggt tat gag gca cga ctt ctg aaa cac gtg cca aaa     1063
 His Leu Leu His Gly Tyr Glu Ala Arg Leu Leu Lys His Val Pro Lys
     325                 330                 335

 att atc cac cta gtt tgc aaa ttg ctg ctg gac tta gcg gag aac agg     1111
 Ile Ile His Leu Val Cys Lys Leu Leu Leu Asp Leu Ala Glu Asn Arg
 340                 345                 350                 355

 cca gtg atg atg aag gat gtg tcc gaa gga cct ggt ctc tct gct gaa     1159
 Pro Val Met Met Lys Asp Val Ser Glu Gly Pro Gly Leu Ser Ala Glu
                 360                 365                 370

 ata gaa aag aca atg tct gag atg gtc acc atg cag ctg gat aaa gag     1207
 Ile Glu Lys Thr Met Ser Glu Met Val Thr Met Gln Leu Asp Lys Glu
             375                 380                 385

 tta ctg agg cat gac agt gat gtg tcc aac ccg cct aac ccc act gca     1255
 Leu Leu Arg His Asp Ser Asp Val Ser Asn Pro Pro Asn Pro Thr Ala
         390                 395                 400

 gtg gca gca gat ttt gac aat cga ggc atg att ttc tcc aat gag caa     1303
 Val Ala Ala Asp Phe Asp Asn Arg Gly Met Ile Phe Ser Asn Glu Gln
     405                 410                 415

 cag ttt gac cct ctt tgg aaa agg cgg aat gtt gag tgc ctt caa ccc     1351
 Gln Phe Asp Pro Leu Trp Lys Arg Arg Asn Val Glu Cys Leu Gln Pro
 420                 425                 430                 435

 ctg act cat ctg aaa agg cgg ctc agc tac agt gac tca gat tta aag     1399
 Leu Thr His Leu Lys Arg Arg Leu Ser Tyr Ser Asp Ser Asp Leu Lys
                 440                 445                 450

 agg gcc gag aac ctc ctg gag caa ggg gag act cca cag aca gtg cct     1447
 Arg Ala Glu Asn Leu Leu Glu Gln Gly Glu Thr Pro Gln Thr Val Pro
             455                 460                 465

 gcc cag atc ttg gtt ggc cac aag ccc agg cag cag aag ctc ata agc     1495
 Ala Gln Ile Leu Val Gly His Lys Pro Arg Gln Gln Lys Leu Ile Ser
         470                 475                 480

 cat tgt tac atc cca cag tct cca gaa cca gac tta cac aag gaa gcc     1543
 His Cys Tyr Ile Pro Gln Ser Pro Glu Pro Asp Leu His Lys Glu Ala
     485                 490                 495

 ttg gtt cgc agc aca ctt tct ttc tgg agt cag tca aag ttt gga ggc     1591
 Leu Val Arg Ser Thr Leu Ser Phe Trp Ser Gln Ser Lys Phe Gly Gly
 500                 505                 510                 515

 ctg gaa gga ctc aaa gat aat ggg tca cca att ttc cat gga agg atc     1639
 Leu Glu Gly Leu Lys Asp Asn Gly Ser Pro Ile Phe His Gly Arg Ile
                 520                 525                 530

 att cca aag gaa gca cag cag agt gga gct ttc tct gca gat gtt tca     1687
 Ile Pro Lys Glu Ala Gln Gln Ser Gly Ala Phe Ser Ala Asp Val Ser
             535                 540                 545

 ggc tca cac agc cct ggg gag cca gtt tca ccc agc ttt gca aat gtc     1735
 Gly Ser His Ser Pro Gly Glu Pro Val Ser Pro Ser Phe Ala Asn Val
         550                 555                 560

 cat aag gat cca aac cct gct cac cag caa gtg tct cac tgt cag tgt     1783
 His Lys Asp Pro Asn Pro Ala His Gln Gln Val Ser His Cys Gln Cys
     565                 570                 575

 aaa act cat ggt gtt ggg agc cct ggc tct gtc agg cag aac agc agg     1831
 Lys Thr His Gly Val Gly Ser Pro Gly Ser Val Arg Gln Asn Ser Arg
 580                 585                 590                 595

 aca ccc cga agc cct ctg gac tgt ggc tcc agt ccc aaa gca cag ttc     1879
 Thr Pro Arg Ser Pro Leu Asp Cys Gly Ser Ser Pro Lys Ala Gln Phe
                 600                 605                 610

 ttg gtt gaa cat gaa acc cag gac agt aaa gat ctg tct gaa gca gct     1927
 Leu Val Glu His Glu Thr Gln Asp Ser Lys Asp Leu Ser Glu Ala Ala
             615                 620                 625

 tca cac tct gca tta cag tct gaa ttg agt gct gag gca aga aga ata     1975
 Ser His Ser Ala Leu Gln Ser Glu Leu Ser Ala Glu Ala Arg Arg Ile
         630                 635                 640

 ctg gcg gcc aaa gcc cta gca aat tta aat gaa tct gta gaa aag gag     2023
 Leu Ala Ala Lys Ala Leu Ala Asn Leu Asn Glu Ser Val Glu Lys Glu
     645                 650                 655

 gaa cta aaa agg aag gta gaa atg tgg cag aaa gag ctt aat tcc cga     2071
 Glu Leu Lys Arg Lys Val Glu Met Trp Gln Lys Glu Leu Asn Ser Arg
 660                 665                 670                 675

 gat gga gct tgg gaa aga ata tgt ggc gag agg gac cct ttc atc cta     2119
 Asp Gly Ala Trp Glu Arg Ile Cys Gly Glu Arg Asp Pro Phe Ile Leu
                 680                 685                 690

 tgc agc ttg atg tgg tct tgg gtg gag caa ctg aag gag cct gta atc     2167
 Cys Ser Leu Met Trp Ser Trp Val Glu Gln Leu Lys Glu Pro Val Ile
             695                 700                 705

 acc aaa gag gat gtg gac atg ttg gtt gac agg cga gca gat gcc gca     2215
 Thr Lys Glu Asp Val Asp Met Leu Val Asp Arg Arg Ala Asp Ala Ala
         710                 715                 720

 gaa gca ctt ttt tta tta gag aag gga cag cac cag act att ctc tgc     2263
 Glu Ala Leu Phe Leu Leu Glu Lys Gly Gln His Gln Thr Ile Leu Cys
     725                 730                 735

 gtg ttg cac tgc ata gtg aac ctg cag aca att ccc gtg gat gtg gag     2311
 Val Leu His Cys Ile Val Asn Leu Gln Thr Ile Pro Val Asp Val Glu
 740                 745                 750                 755

 gaa gct ttc ctt gcc cat gcc att aag gca ttc act aag gtt aat ttt     2359
 Glu Ala Phe Leu Ala His Ala Ile Lys Ala Phe Thr Lys Val Asn Phe
                 760                 765                 770

 gat tct gaa aat gga cca aca gtt tac aac acc ctg aag aaa ata ttt     2407
 Asp Ser Glu Asn Gly Pro Thr Val Tyr Asn Thr Leu Lys Lys Ile Phe
             775                 780                 785

 aag cac acg ctg gaa gaa aaa aga aaa atg aca aaa gat ggc cct aag     2455
 Lys His Thr Leu Glu Glu Lys Arg Lys Met Thr Lys Asp Gly Pro Lys
         790                 795                 800

 cct ggc ctc tag ctt tcactcgtgg tgaatatttc agacctaaag atccagatag     2510
 Pro Gly Leu 
     805

 tatctctgtt catatgtgaa taagttgaag attgtggggc tactttttct catagcactt   2570

 tattttgaat gttgttagtt tgtgctgaga atggtcgtcc gtatttgaac caattattta   2630

 ttttaaaata tatttaagct acatttttgt tttgaaaaat tgccataaat ttggtgccac   2690

 tttcttttat ttatttgact gagttaatat tattgtatta acattttaag tatatggtgt   2750

 ttacattctt atttcttttg acattttgga aataatcata acttgtcttt ccaaaataac   2810

 cattttcttg atggaactct tcctagagtt tttaccaaat agctaacttt agtagtaaaa   2870

 cctcattgtg tatccattcc cccacagatg aactaagaaa gtcaccaagt gtcttaagct   2930

 gttttatatt tgttacgaag aaggctattg ctacaatatt tttaaaggtt tcttttttaa   2990

 ctttgaaaat ttttggtttt ccttttcttt ttaataaagg tccagaaggt tt           3042




      <210> 115
      <211> 3139
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (198)..(1967)

      <400> 115
 cgacgatttc gtgcggtggc gggcgggggc ctctggtatc cctggtgacg ctgtatctgt     60

 gggctcttga atcgcgtcac aaatcagcga ccgaactctg gcggtggtgg ttaagacggc    120

 gaaggcggca gcggcggcga cagctctggg gtttgcgtct cggggtgtgt cggccgccgc    180

 tgctgcttgg gcctggt   atg tac aga tgg ctg gtt agg att ctc ggc acc     230
                      Met Tyr Arg Trp Leu Val Arg Ile Leu Gly Thr
                        1               5                  10

 att ttc cgt ttc tgc gac cgg tcg gtg ccc cct gcc cgg gcc ctc ctg      278
 Ile Phe Arg Phe Cys Asp Arg Ser Val Pro Pro Ala Arg Ala Leu Leu
              15                  20                  25

 aag agg cgg cgc tca gac agc act ctg ttt tct aca gtg gac act gat      326
 Lys Arg Arg Arg Ser Asp Ser Thr Leu Phe Ser Thr Val Asp Thr Asp
          30                  35                  40

 gaa ata cca gcc aaa aga cca aga tta gat tgc ttt att cac caa gtg      374
 Glu Ile Pro Ala Lys Arg Pro Arg Leu Asp Cys Phe Ile His Gln Val
      45                  50                  55

 aaa aac agt ctc tac aat gct gcc agc tta ttt gga ttc cca ttc cag      422
 Lys Asn Ser Leu Tyr Asn Ala Ala Ser Leu Phe Gly Phe Pro Phe Gln
  60                  65                  70                  75

 ctg acc aca aag ccc atg gta act tct gct tgt aat gga aca cgg aat      470
 Leu Thr Thr Lys Pro Met Val Thr Ser Ala Cys Asn Gly Thr Arg Asn
                  80                  85                  90

 gtg gcc cct tca gga gag gta ttt tcg aac tct tca tct tgt gaa ctg      518
 Val Ala Pro Ser Gly Glu Val Phe Ser Asn Ser Ser Ser Cys Glu Leu
              95                 100                 105

 aca ggt tct gga tcc tgg aac aac atg ctg aaa ctg ggt aat aaa tct      566
 Thr Gly Ser Gly Ser Trp Asn Asn Met Leu Lys Leu Gly Asn Lys Ser
         110                 115                 120

 cct aat gga ata agt gac tat cca aag atc aga gtg aca gtt acc cga      614
 Pro Asn Gly Ile Ser Asp Tyr Pro Lys Ile Arg Val Thr Val Thr Arg
     125                 130                 135

 gat cag cca cgc aga gtc ctg cct tcc ttt ggt ttt act ttg aac tca      662
 Asp Gln Pro Arg Arg Val Leu Pro Ser Phe Gly Phe Thr Leu Asn Ser
 140                 145                 150                 155

 gaa ggc tgt aat aga aga cca ggt ggc cgt cgc cat agc aaa ggt aat      710
 Glu Gly Cys Asn Arg Arg Pro Gly Gly Arg Arg His Ser Lys Gly Asn
                 160                 165                 170

 cca gag agt tct tta atg tgg aaa cct cag gaa cag gct gta aca gag      758
 Pro Glu Ser Ser Leu Met Trp Lys Pro Gln Glu Gln Ala Val Thr Glu
             175                 180                 185

 atg att tct gaa gag agt ggc aag ggt ctg agg cgt ccc cat tgt act      806
 Met Ile Ser Glu Glu Ser Gly Lys Gly Leu Arg Arg Pro His Cys Thr
         190                 195                 200

 gtg gag gag ggt gtt caa aaa gag gaa aga gag aag tac cga aag tta      854
 Val Glu Glu Gly Val Gln Lys Glu Glu Arg Glu Lys Tyr Arg Lys Leu
     205                 210                 215

 ttg gaa cga ctt aaa gaa agt ggt cat gga aac tct gtc tgt cct gta      902
 Leu Glu Arg Leu Lys Glu Ser Gly His Gly Asn Ser Val Cys Pro Val
 220                 225                 230                 235

 act tca aat tat cac agt tct caa aga agt cag atg gac aca tta aag      950
 Thr Ser Asn Tyr His Ser Ser Gln Arg Ser Gln Met Asp Thr Leu Lys
                 240                 245                 250

 acc aaa ggc tgg ggg gaa gag caa aat cac gga gtc aaa aca act cag      998
 Thr Lys Gly Trp Gly Glu Glu Gln Asn His Gly Val Lys Thr Thr Gln
             255                 260                 265

 ttt gtt cca aaa caa tat aga ctt gtt gaa aca agg gga cct cta tgt     1046
 Phe Val Pro Lys Gln Tyr Arg Leu Val Glu Thr Arg Gly Pro Leu Cys
         270                 275                 280

 tca ttg aga agt gaa aag agg tgt tca aag ggg aaa att act gat aca     1094
 Ser Leu Arg Ser Glu Lys Arg Cys Ser Lys Gly Lys Ile Thr Asp Thr
     285                 290                 295

 gag acg atg gtc gga atc aga ttt gaa aat gaa agt agg agg gga tac     1142
 Glu Thr Met Val Gly Ile Arg Phe Glu Asn Glu Ser Arg Arg Gly Tyr
 300                 305                 310                 315

 caa ctg gag cct gac cta tca gaa gaa gtg tcg gcc cga ctc cgc ctg     1190
 Gln Leu Glu Pro Asp Leu Ser Glu Glu Val Ser Ala Arg Leu Arg Leu
                 320                 325                 330

 ggc agt gga agc aat ggc tta ctc agg agg aaa gtg tca ata att gag     1238
 Gly Ser Gly Ser Asn Gly Leu Leu Arg Arg Lys Val Ser Ile Ile Glu
             335                 340                 345

 aca aag gaa aag aat tgc tca ggc aaa gag agg gac aga aga acg gac     1286
 Thr Lys Glu Lys Asn Cys Ser Gly Lys Glu Arg Asp Arg Arg Thr Asp
         350                 355                 360

 gat ctc ctt gaa ctt aca gag gac atg gaa aag gaa atc agt aat gcc     1334
 Asp Leu Leu Glu Leu Thr Glu Asp Met Glu Lys Glu Ile Ser Asn Ala
     365                 370                 375

 cta ggc cat ggc cca cag gat gaa atc cta agt agt gct ttc aaa ttg     1382
 Leu Gly His Gly Pro Gln Asp Glu Ile Leu Ser Ser Ala Phe Lys Leu
 380                 385                 390                 395

 cga att act cga gga gat att cag aca tta aag aac tat cac tgg ctc     1430
 Arg Ile Thr Arg Gly Asp Ile Gln Thr Leu Lys Asn Tyr His Trp Leu
                 400                 405                 410

 aat gat gaa gtc att aat ttt tac atg aat ctt ctg gtg gaa aga aat     1478
 Asn Asp Glu Val Ile Asn Phe Tyr Met Asn Leu Leu Val Glu Arg Asn
             415                 420                 425

 aaa aag caa ggc tat cca gca ctt cat gta ttc agt act ttc ttc tat     1526
 Lys Lys Gln Gly Tyr Pro Ala Leu His Val Phe Ser Thr Phe Phe Tyr
         430                 435                 440

 cct aaa tta aag tct ggg ggt tac caa gca gtg aaa cga tgg acc aaa     1574
 Pro Lys Leu Lys Ser Gly Gly Tyr Gln Ala Val Lys Arg Trp Thr Lys
     445                 450                 455

 ggg gta aat ctc ttt gaa caa gaa att att ctg gtg cct att cat cgg     1622
 Gly Val Asn Leu Phe Glu Gln Glu Ile Ile Leu Val Pro Ile His Arg
 460                 465                 470                 475

 aag gta cat tgg agc ctg gtg gtg att gac cta aga aaa aag tgt ctt     1670
 Lys Val His Trp Ser Leu Val Val Ile Asp Leu Arg Lys Lys Cys Leu
                 480                 485                 490

 aaa tat ctg gat tct atg gga caa aag ggc cac agg atc tgt gag att     1718
 Lys Tyr Leu Asp Ser Met Gly Gln Lys Gly His Arg Ile Cys Glu Ile
             495                 500                 505

 ctc ctt cag tat tta cag gat gaa agt aag acc aaa aga aat agt gat     1766
 Leu Leu Gln Tyr Leu Gln Asp Glu Ser Lys Thr Lys Arg Asn Ser Asp
         510                 515                 520

 ctg aat ctt tta gag tgg acc cat cac agc atg aaa cca cac gag att     1814
 Leu Asn Leu Leu Glu Trp Thr His His Ser Met Lys Pro His Glu Ile
     525                 530                 535

 cct caa cag ctg aat ggg agt gat tgt gga atg ttt act tgt aaa tat     1862
 Pro Gln Gln Leu Asn Gly Ser Asp Cys Gly Met Phe Thr Cys Lys Tyr
 540                 545                 550                 555

 gca gat tat att tct agg gac aaa cct atc aca ttt act cag cac cag     1910
 Ala Asp Tyr Ile Ser Arg Asp Lys Pro Ile Thr Phe Thr Gln His Gln
                 560                 565                 570

 atg cct ctc ttc cgg aag aag atg gtg tgg gaa atc ctt cat cag cag     1958
 Met Pro Leu Phe Arg Lys Lys Met Val Trp Glu Ile Leu His Gln Gln
             575                 580                 585

 ttg ctg tga gaaaact ttgcctggtc cctctagctg ctggtggttc tttcacagac     2014
 Leu Leu 


 atttccatat acctcatgca ttgtgggtta aaaagtccct gcatcacttc tgttctcaca   2074

 ggtactgagc tgtcaaaagt gcatgaaggc ctctcactgt actctagtcc tgacttgggg   2134

 tgcagagggc tgcttgcaat cctgtttgta aggctgtgcc tgctcagagc tttggactgt   2194

 tcaacccaca caagaacaaa cgctaactaa tatttttttt aagagattct tttccctatg   2254

 aatgtgggaa atgcaggatt tattctgtga attgtttgtt tctgtgtgtt tgttcagcgt   2314

 attcattcac tcactcgttt gcaaacataa tgggcagtgg tcatttactg ctgctctttt   2374

 acagttagct ctaaattact tgtttgaact atttatttct gaaaggaatg ttactcaagc   2434

 tgccactccc tgctgaagag caggagggaa ctctcactgg gggcggaagg aagtggagct   2494

 ggagcagtaa ctgccaacat gaagctggag ggtttgggat tttttttgtt tttgtttttt   2554

 tgaggctcaa aaaatgctgg gagaaatgaa aatgctgtgg gatagggctc ctgttgcctt   2614

 tcagaggaag tctgacacta cagcgttggc acagtgccgt gaacagtgga actgtgccca   2674

 agggactctg actatccaag catcttccga agagtgttgt ggtcacctta aagagacttc   2734

 cctttctgga aatgtggtga cttggcttag tcttcaaact ggattcatgg atttgaagta   2794

 actgtaaacc ctaaatcttc attttcatcc cagatctggt tgagtataaa cctcagaatt   2854

 gtaggggctg gcctgagctg tttatttcaa aagatactat tcaatttaaa gctatttttc   2914

 ctcagagttt ttgttttcta tatattaagt ctaaattaag ttttctactc attaagacta   2974

 acatctcccc actccatccc cactgaaatt tgtggaagaa aatttagtac ttggctctga   3034

 ggttgccagt tatacaataa tctattttgc atatgaaagt ttgtatttaa cttttttgtt   3094

 cattaaaaac cttactgata tggttataac ttcaaaaaaa aaaaa                   3139




      <210> 116
      <211> 3664
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(2911)

      <400> 116
 catcatccct gataactccc tcctcattcc cagaaaatgg  atg cta tcc agt cac      55
                                              Met Leu Ser Ser His
                                                1               5

 ttc tac ttc tgt gcc tac cct gcg gca gaa cat gga gaa agg tac aac      103
 Phe Tyr Phe Cys Ala Tyr Pro Ala Ala Glu His Gly Glu Arg Tyr Asn
                  10                  15                  20

 tta tcc tta agg aat ttc cag gat aac ttt gac cac ata atc gat aag      151
 Leu Ser Leu Arg Asn Phe Gln Asp Asn Phe Asp His Ile Ile Asp Lys
              25                  30                  35

 aaa atg tct gat gct cag ggc agc tac aaa ctg gat gaa gct cag gct      199
 Lys Met Ser Asp Ala Gln Gly Ser Tyr Lys Leu Asp Glu Ala Gln Ala
          40                  45                  50

 gtc ttg aga gaa aca aaa gcc atc aaa aag gct att acc tgt ggg gaa      247
 Val Leu Arg Glu Thr Lys Ala Ile Lys Lys Ala Ile Thr Cys Gly Glu
      55                  60                  65

 aag gaa aag caa gat ctc att aag agc ctt gcc atg ttg aag gac ggc      295
 Lys Glu Lys Gln Asp Leu Ile Lys Ser Leu Ala Met Leu Lys Asp Gly
  70                  75                  80                  85

 ttc cgc act gac agg ggg tct cac tca gac ctg tgg tcc agc agc agc      343
 Phe Arg Thr Asp Arg Gly Ser His Ser Asp Leu Trp Ser Ser Ser Ser
                  90                  95                 100

 tct ctg gag agt tcg agt ttc ccg cta ccg aaa cag tac ctg gat gtg      391
 Ser Leu Glu Ser Ser Ser Phe Pro Leu Pro Lys Gln Tyr Leu Asp Val
             105                 110                 115

 agc tcc cag aca gac atc tcg gga agc ttc ggc atc aac agc aac aat      439
 Ser Ser Gln Thr Asp Ile Ser Gly Ser Phe Gly Ile Asn Ser Asn Asn
         120                 125                 130

 cag ttg gca gag aag gtc aga ttg cgc ctt cga tat gaa gag gct aag      487
 Gln Leu Ala Glu Lys Val Arg Leu Arg Leu Arg Tyr Glu Glu Ala Lys
     135                 140                 145

 aga agg atc gcc aac ctg aag atc cag ctg gcc aag ctt gac agt gag      535
 Arg Arg Ile Ala Asn Leu Lys Ile Gln Leu Ala Lys Leu Asp Ser Glu
 150                 155                 160                 165

 gcc tgg cct ggg gtg ctg gac tca gag agg gac cgg ctg atc ctt atc      583
 Ala Trp Pro Gly Val Leu Asp Ser Glu Arg Asp Arg Leu Ile Leu Ile
                 170                 175                 180

 aac gag aag gag gag ctg ctg aag gag atg cgc ttc atc agc ccc cgc      631
 Asn Glu Lys Glu Glu Leu Leu Lys Glu Met Arg Phe Ile Ser Pro Arg
             185                 190                 195

 aag tgg acc cag ggg gag gtg gag cag ctg gag atg gcc cgg aag cgg      679
 Lys Trp Thr Gln Gly Glu Val Glu Gln Leu Glu Met Ala Arg Lys Arg
         200                 205                 210

 ctg gaa aag gac ctg cag gca gcc cgg gac acc cag agc aag gcg ctg      727
 Leu Glu Lys Asp Leu Gln Ala Ala Arg Asp Thr Gln Ser Lys Ala Leu
     215                 220                 225

 acg gag agg tta aag tta aac agt aag agg aac cag ctt gtg agg gaa      775
 Thr Glu Arg Leu Lys Leu Asn Ser Lys Arg Asn Gln Leu Val Arg Glu
 230                 235                 240                 245

 ctg gaa gaa gcc acc cgg cag gtg gca act ctg cac tcc cag ctg aaa      823
 Leu Glu Glu Ala Thr Arg Gln Val Ala Thr Leu His Ser Gln Leu Lys
                 250                 255                 260

 agt ctc tca agc agc atg cag tcc ctg tcc tca ggc agc agc ccc gga      871
 Ser Leu Ser Ser Ser Met Gln Ser Leu Ser Ser Gly Ser Ser Pro Gly
             265                 270                 275

 tcc ctc acg tcc agc cgg ggc tcc ctg gtt gca tcc agc ctg gac tcc      919
 Ser Leu Thr Ser Ser Arg Gly Ser Leu Val Ala Ser Ser Leu Asp Ser
         280                 285                 290

 tcc act tca gcc agc ttc act gac ctc tac tat gac ccc ttt gag cag      967
 Ser Thr Ser Ala Ser Phe Thr Asp Leu Tyr Tyr Asp Pro Phe Glu Gln
     295                 300                 305

 ctg gac tca gag ctg cag agc aag gtg gag ttc ctg ctc ctg gag ggg     1015
 Leu Asp Ser Glu Leu Gln Ser Lys Val Glu Phe Leu Leu Leu Glu Gly
 310                 315                 320                 325

 gcc acc ggc ttc cgg ccc tca ggc tgc atc acc acc atc cac gag gat     1063
 Ala Thr Gly Phe Arg Pro Ser Gly Cys Ile Thr Thr Ile His Glu Asp
                 330                 335                 340

 gag gtg gcc aag acc cag aag gca gag gga ggt ggc cgc ctg cag gct     1111
 Glu Val Ala Lys Thr Gln Lys Ala Glu Gly Gly Gly Arg Leu Gln Ala
             345                 350                 355

 ctg cgt tcc ctg tct ggc acc cca aag tcc atg acc tcc cta tcc cca     1159
 Leu Arg Ser Leu Ser Gly Thr Pro Lys Ser Met Thr Ser Leu Ser Pro
         360                 365                 370

 cgt tcc tct ctc tcc tcc ccc tcc cca ccc tgt tcc cct ctc atg gct     1207
 Arg Ser Ser Leu Ser Ser Pro Ser Pro Pro Cys Ser Pro Leu Met Ala
     375                 380                 385

 gac ccc ctc ctg gct ggt gat gcc ttc ctc aac tcc ttg gag ttt gaa     1255
 Asp Pro Leu Leu Ala Gly Asp Ala Phe Leu Asn Ser Leu Glu Phe Glu
 390                 395                 400                 405

 gac ccg gag ctg agt gcc act ctt tgt gaa ctg agc ctt ggt aac agc     1303
 Asp Pro Glu Leu Ser Ala Thr Leu Cys Glu Leu Ser Leu Gly Asn Ser
                 410                 415                 420

 gcc cag gaa aga tac cgg ctg gag gaa cca gga acg gag ggc aag cag     1351
 Ala Gln Glu Arg Tyr Arg Leu Glu Glu Pro Gly Thr Glu Gly Lys Gln
             425                 430                 435

 ctg ggc caa gct gtg aat acg gcc cag ggg tgt ggc ctg aaa gtg gcc     1399
 Leu Gly Gln Ala Val Asn Thr Ala Gln Gly Cys Gly Leu Lys Val Ala
         440                 445                 450

 tgt gtc tca gcc gcc gta tcg gac gag tca gtg gct gga gac agt ggt     1447
 Cys Val Ser Ala Ala Val Ser Asp Glu Ser Val Ala Gly Asp Ser Gly
     455                 460                 465

 gtg tac gag gct tcc gtg cag aga ctg ggt gct tca gaa gct gct gca     1495
 Val Tyr Glu Ala Ser Val Gln Arg Leu Gly Ala Ser Glu Ala Ala Ala
 470                 475                 480                 485

 ttt gac agt gac gaa tcg gaa gca gtg ggt gcg acc cga att cag att     1543
 Phe Asp Ser Asp Glu Ser Glu Ala Val Gly Ala Thr Arg Ile Gln Ile
                 490                 495                 500

 gcc ctg aag tat gat gag aag aat aag caa ttt gca ata tta atc atc     1591
 Ala Leu Lys Tyr Asp Glu Lys Asn Lys Gln Phe Ala Ile Leu Ile Ile
             505                 510                 515

 cag ctg agt aac ctt tct gct ctg ttg cag caa caa gac cag aaa gtg     1639
 Gln Leu Ser Asn Leu Ser Ala Leu Leu Gln Gln Gln Asp Gln Lys Val
         520                 525                 530

 aat atc cgc gtg gct gtc ctt cct tgc tct gaa agc aca acc tgc ctg     1687
 Asn Ile Arg Val Ala Val Leu Pro Cys Ser Glu Ser Thr Thr Cys Leu
     535                 540                 545

 ttc cgg acc cgg cct ctg gac gcc tca gac act cta gtg ttc aat gag     1735
 Phe Arg Thr Arg Pro Leu Asp Ala Ser Asp Thr Leu Val Phe Asn Glu
 550                 555                 560                 565

 gtg ttc tgg gta tcc atg tcc tat cca gcc ctt cac cag aag acc tta     1783
 Val Phe Trp Val Ser Met Ser Tyr Pro Ala Leu His Gln Lys Thr Leu
                 570                 575                 580

 aga gtc gat gtc tgt acc acc gac agg agc cat ctg gaa gag tgc ctg     1831
 Arg Val Asp Val Cys Thr Thr Asp Arg Ser His Leu Glu Glu Cys Leu
             585                 590                 595

 gga ggc gcc cag atc agc ctg gcg gag gtc tgc cgg tct ggg gag agg     1879
 Gly Gly Ala Gln Ile Ser Leu Ala Glu Val Cys Arg Ser Gly Glu Arg
         600                 605                 610

 tcg act cgc tgg tac aac ctt ctc agc tac aaa tac ttg aag aaa cag     1927
 Ser Thr Arg Trp Tyr Asn Leu Leu Ser Tyr Lys Tyr Leu Lys Lys Gln
     615                 620                 625

 agc agg gag ctc aag cca gtg gga gtc atg gcc cct gcc tca ggg cct     1975
 Ser Arg Glu Leu Lys Pro Val Gly Val Met Ala Pro Ala Ser Gly Pro
 630                 635                 640                 645

 gcc agc acg gac gct gtg tct gct ctg ttg gaa cag aca gca gtg gag     2023
 Ala Ser Thr Asp Ala Val Ser Ala Leu Leu Glu Gln Thr Ala Val Glu
                 650                 655                 660

 ctg gag aag agg cag gag ggc agg agc agc aca cag aca ctg gaa gac     2071
 Leu Glu Lys Arg Gln Glu Gly Arg Ser Ser Thr Gln Thr Leu Glu Asp
             665                 670                 675

 agc tgg agg tat gag gag acc agt gag aat gag gca gta gcc gag gaa     2119
 Ser Trp Arg Tyr Glu Glu Thr Ser Glu Asn Glu Ala Val Ala Glu Glu
         680                 685                 690

 gag gag gag gag gtg gag gag gag gag gga gaa gag gat gtt ttc acc     2167
 Glu Glu Glu Glu Val Glu Glu Glu Glu Gly Glu Glu Asp Val Phe Thr
     695                 700                 705

 gag aaa gcc tca cct gat atg gat ggg tac cca gca tta aag gtg gac     2215
 Glu Lys Ala Ser Pro Asp Met Asp Gly Tyr Pro Ala Leu Lys Val Asp
 710                 715                 720                 725

 aaa gag acc aac acg gag acc ccg gcc cca tcc ccc aca gtg gtg cga     2263
 Lys Glu Thr Asn Thr Glu Thr Pro Ala Pro Ser Pro Thr Val Val Arg
                 730                 735                 740

 cct aag gac cgg aga gtg ggc acc ccg tcc cag ggg cca ttt ctt cga     2311
 Pro Lys Asp Arg Arg Val Gly Thr Pro Ser Gln Gly Pro Phe Leu Arg
             745                 750                 755

 ggg agc acc atc atc cgc tct aag acc ttc tcc cca gga ccc cag agc     2359
 Gly Ser Thr Ile Ile Arg Ser Lys Thr Phe Ser Pro Gly Pro Gln Ser
         760                 765                 770

 cag tac gtg tgc cgg ctg aat cgg agt gat agt gac agc tcc act ctg     2407
 Gln Tyr Val Cys Arg Leu Asn Arg Ser Asp Ser Asp Ser Ser Thr Leu
     775                 780                 785

 tcc aaa aag cca cct ttt gtt cga aac tcc ctg gag cga cgc agc gtc     2455
 Ser Lys Lys Pro Pro Phe Val Arg Asn Ser Leu Glu Arg Arg Ser Val
 790                 795                 800                 805

 cgg atg aag cgg ccg tcc cca ccc cca cag cct tcc tcg gtc aag tcg     2503
 Arg Met Lys Arg Pro Ser Pro Pro Pro Gln Pro Ser Ser Val Lys Ser
                 810                 815                 820

 ctg cgc tcc gag cgt ctg atc cgt acc tcg ctg gac ctg gag tta gac     2551
 Leu Arg Ser Glu Arg Leu Ile Arg Thr Ser Leu Asp Leu Glu Leu Asp
             825                 830                 835

 ctg cag gcg aca aga acc tgg cac agc caa ttg acc cag gag atc tcg     2599
 Leu Gln Ala Thr Arg Thr Trp His Ser Gln Leu Thr Gln Glu Ile Ser
         840                 845                 850

 gtg ctg aag gag ctc aag gag cag ctg gaa caa gcc aag agc cac ggg     2647
 Val Leu Lys Glu Leu Lys Glu Gln Leu Glu Gln Ala Lys Ser His Gly
     855                 860                 865

 gag aag gag ctg cca cag tgg ttg cgt gag gac gag cgt ttc cgc ctg     2695
 Glu Lys Glu Leu Pro Gln Trp Leu Arg Glu Asp Glu Arg Phe Arg Leu
 870                 875                 880                 885

 ctg ctg agg atg ctg gag aag cgg cag atg gac cga gcg gac gac aag     2743
 Leu Leu Arg Met Leu Glu Lys Arg Gln Met Asp Arg Ala Asp Asp Lys
                 890                 895                 900

 ggt gag ctt cag aca gac aag atg atg agg gca gct gcc aag gat gtg     2791
 Gly Glu Leu Gln Thr Asp Lys Met Met Arg Ala Ala Ala Lys Asp Val
             905                 910                 915

 cac agg ctc cga ggc cag agc tgt aag gaa ccc cca gaa gtt cag tct     2839
 His Arg Leu Arg Gly Gln Ser Cys Lys Glu Pro Pro Glu Val Gln Ser
         920                 925                 930

 ttc agg gag aag atg gca ttt ttc acc cgg cct cgg atg aat atc cca     2887
 Phe Arg Glu Lys Met Ala Phe Phe Thr Arg Pro Arg Met Asn Ile Pro
     935                 940                 945

 gct ctc tct gca gat gac gtc taa tcgccagaaa agtatttcct ttgttccact    2941
 Ala Leu Ser Ala Asp Asp Val 
 950                 955

 gaccaggctg tgaacattga ctgtggctaa agttatttat gtggtgttat atgaaggtac   3001

 tgagtcacaa gtcctctagt gctcttgttg gtttgaagat gaaccgactt tttagtttgg   3061

 gtcctactgt tgttattaaa aacagaacaa aaacaaaaca cacacacaca caaaaacaga   3121

 aacaaaaaaa accagcatta aaataataag attgtatagt ttgtatattt aggagtgtat   3181

 ttttgggaaa gaaaatttaa atgaactaaa gcagtattga gttgctgctc ttcttaaaat   3241

 cgtttagatt ttttttggtt tgtacagctc caccttttag aggtcttact gcaataagaa   3301

 gtaatgcctg ggggacggta atcctaatag gacgtcccgc acttgtcaca gtacagctaa   3361

 tttttcctag ttaacatatt ttgtacaata ttaaaaaaat gcacagaaac cattgggggg   3421

 gattcagagg tgcatccacg gatcttcttg agctgtgacg tgtttttatg tggctgccca   3481

 acgtggagcg ggcagtgtga taggctgggt gggctaagca gcctagtcta tgtgggtgac   3541

 aggccacgct ggtctcagat gcccagtgaa gccactaaca tgagtgaggg gagggctgtg   3601

 gggaactcca ttcagtttta tctccatcaa taaagtggcc tttcaaaaag aaaaaaaaaa   3661

 aaa                                                                 3664




      <210> 117
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (70)..(1191)

      <400> 117
 tttcgtggaa gctagggtta gaggcaaccc gtgaggctag aaccccgaac gtggtcggtt     60

 ggagcaaat    atg tcc ctc cgg agg cac att ggg aac cct gag tat ctg     108
              Met Ser Leu Arg Arg His Ile Gly Asn Pro Glu Tyr Leu
                1               5                  10

 atg aaa agg ata cca cag aac cca aga tac cag cat atc aaa tca aga      156
 Met Lys Arg Ile Pro Gln Asn Pro Arg Tyr Gln His Ile Lys Ser Arg
      15                  20                  25

 ctg gac act ggt aac agt atg act aaa tat act gag aag ctc gaa gag      204
 Leu Asp Thr Gly Asn Ser Met Thr Lys Tyr Thr Glu Lys Leu Glu Glu
  30                  35                  40                  45

 att aag aaa aat tat aga tac aaa aaa gat gag ctt ttc aag aga cta      252
 Ile Lys Lys Asn Tyr Arg Tyr Lys Lys Asp Glu Leu Phe Lys Arg Leu
                  50                  55                  60

 aaa gtt aca act ttt gcc cag ctg atc atc caa gtt gct tcc ctc tct      300
 Lys Val Thr Thr Phe Ala Gln Leu Ile Ile Gln Val Ala Ser Leu Ser
              65                  70                  75

 gat caa aca ctg gaa gtg aca gct gag gag att caa agg ctg gaa gac      348
 Asp Gln Thr Leu Glu Val Thr Ala Glu Glu Ile Gln Arg Leu Glu Asp
          80                  85                  90

 aat gat tct gca gct tca gac cct gat gct gaa acc act gcc agg acc      396
 Asn Asp Ser Ala Ala Ser Asp Pro Asp Ala Glu Thr Thr Ala Arg Thr
      95                 100                 105

 aat ggg aaa gga aat cca ggt gag cag tcg ccg agc cct gag cag ttc      444
 Asn Gly Lys Gly Asn Pro Gly Glu Gln Ser Pro Ser Pro Glu Gln Phe
 110                 115                 120                 125

 ata aac aac gca gga gca ggg gac tcc agc cgc tca act ctt cag agt      492
 Ile Asn Asn Ala Gly Ala Gly Asp Ser Ser Arg Ser Thr Leu Gln Ser
                 130                 135                 140

 gtc atc agt ggt gtt ggg gaa ctg gat cta gac aaa ggg cca gtg aag      540
 Val Ile Ser Gly Val Gly Glu Leu Asp Leu Asp Lys Gly Pro Val Lys
             145                 150                 155

 aaa gca gag ccc cat acc aaa gac aaa cct tat cct gac tgc ccc ttc      588
 Lys Ala Glu Pro His Thr Lys Asp Lys Pro Tyr Pro Asp Cys Pro Phe
         160                 165                 170

 ctg ctg cta gat gtg cgt gat aga gat tct tac cag cag tgc cac att      636
 Leu Leu Leu Asp Val Arg Asp Arg Asp Ser Tyr Gln Gln Cys His Ile
     175                 180                 185

 gtt gga gct tac agt tac cca att gca act ctg tct aga aca atg aac      684
 Val Gly Ala Tyr Ser Tyr Pro Ile Ala Thr Leu Ser Arg Thr Met Asn
 190                 195                 200                 205

 cct tat tca aat gat att ctt gaa tat aaa aat gcc cat ggc aag atc      732
 Pro Tyr Ser Asn Asp Ile Leu Glu Tyr Lys Asn Ala His Gly Lys Ile
                 210                 215                 220

 atc att ctg tat gac gat gat gaa agg ctg gcc agt cag gcg gcc acc      780
 Ile Ile Leu Tyr Asp Asp Asp Glu Arg Leu Ala Ser Gln Ala Ala Thr
             225                 230                 235

 acc atg tgc gag cgt gga ttt gaa aac ctc ttc atg ctt tcc gga ggt      828
 Thr Met Cys Glu Arg Gly Phe Glu Asn Leu Phe Met Leu Ser Gly Gly
         240                 245                 250

 cta aaa gtc tta gct cag aaa ttc ccg gaa gga ctg att act ggt tcc      876
 Leu Lys Val Leu Ala Gln Lys Phe Pro Glu Gly Leu Ile Thr Gly Ser
     255                 260                 265

 ctg cca gca tct tgc cag cag gcc ctt cct cct ggg tct gcc cgg aaa      924
 Leu Pro Ala Ser Cys Gln Gln Ala Leu Pro Pro Gly Ser Ala Arg Lys
 270                 275                 280                 285

 cga tcc agc ccc aaa ggg cca ccc cta cca gct gag aat aaa tgg aga      972
 Arg Ser Ser Pro Lys Gly Pro Pro Leu Pro Ala Glu Asn Lys Trp Arg
                 290                 295                 300

 ttt acc cca gaa gac tta aaa aag ata gaa tat tat ctg gaa gag gag     1020
 Phe Thr Pro Glu Asp Leu Lys Lys Ile Glu Tyr Tyr Leu Glu Glu Glu
             305                 310                 315

 caa ggg cct gca gat cat cct agc cga ctg aac caa gct aac tcc tcc     1068
 Gln Gly Pro Ala Asp His Pro Ser Arg Leu Asn Gln Ala Asn Ser Ser
         320                 325                 330

 gga aga gag tcc aag gtg cct ggt gcc cga agc gct cag aat ctg cca     1116
 Gly Arg Glu Ser Lys Val Pro Gly Ala Arg Ser Ala Gln Asn Leu Pro
     335                 340                 345

 ggt ggc ggc ccc gcc agc cac tca aac ccc cgc tcc ctc agc agt ggt     1164
 Gly Gly Gly Pro Ala Ser His Ser Asn Pro Arg Ser Leu Ser Ser Gly
 350                 355                 360                 365

 cac ctg caa ggc aaa ccc tgg aag taa agact ttgtctcact taggcaaata     1216
 His Leu Gln Gly Lys Pro Trp Lys 
                 370

 aatgttcttc ctcttttcag aaaaaaaaaa aa                                 1248




      <210> 118
      <211> 6202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(4890)

      <400> 118
 gaccgggaca cagataagaa acgaattgag gagctgctgg aagaaaac atg gtc ctt      57
                                                      Met Val Leu
                                                        1

 gag att gca cag aag cag agc atg aac gaa tct gcc cac ctt ggc tgg      105
 Glu Ile Ala Gln Lys Gln Ser Met Asn Glu Ser Ala His Leu Gly Trp
       5                  10                  15

 gag ctg gag cag ctg tcc aag aac gca gac ttg tca gac gcc tcc agg      153
 Glu Leu Glu Gln Leu Ser Lys Asn Ala Asp Leu Ser Asp Ala Ser Arg
  20                  25                  30                  35

 aag tcg ttt gtg ttt gag ctg aac gaa tgt gcg tcc agc cgc atc ctg      201
 Lys Ser Phe Val Phe Glu Leu Asn Glu Cys Ala Ser Ser Arg Ile Leu
                  40                  45                  50

 aag ctg gag aag gag aat cag agc ctc cag agc acc atc cag ggg ctg      249
 Lys Leu Glu Lys Glu Asn Gln Ser Leu Gln Ser Thr Ile Gln Gly Leu
              55                  60                  65

 cgg gac gcg tcc ctg gtg ttg gag gag agc ggc ctc aag tgc ggg gag      297
 Arg Asp Ala Ser Leu Val Leu Glu Glu Ser Gly Leu Lys Cys Gly Glu
          70                  75                  80

 ctg gag aag gag aac cac cag ctc agc aag aag att gaa aag tta caa      345
 Leu Glu Lys Glu Asn His Gln Leu Ser Lys Lys Ile Glu Lys Leu Gln
      85                  90                  95

 acc cag ctg gag aga gaa aag cag agc aac caa gat ctg gag acc ctc      393
 Thr Gln Leu Glu Arg Glu Lys Gln Ser Asn Gln Asp Leu Glu Thr Leu
 100                 105                 110                 115

 agt gag gag ctg atc aga gag aag gag cag ctg cag agt gac atg gag      441
 Ser Glu Glu Leu Ile Arg Glu Lys Glu Gln Leu Gln Ser Asp Met Glu
                 120                 125                 130

 acc ctg aag gct gac aaa gcc agg cag atc aag gac ctt gag cag gaa      489
 Thr Leu Lys Ala Asp Lys Ala Arg Gln Ile Lys Asp Leu Glu Gln Glu
             135                 140                 145

 aag gac cac ctc aac cga gcc atg tgg tcg ctg cgg gag agg tcg cag      537
 Lys Asp His Leu Asn Arg Ala Met Trp Ser Leu Arg Glu Arg Ser Gln
         150                 155                 160

 gtc agc agt gag gcc cgc atg aaa gac gtg gag aag gag aac aaa gcc      585
 Val Ser Ser Glu Ala Arg Met Lys Asp Val Glu Lys Glu Asn Lys Ala
     165                 170                 175

 ctc cac cag acg gtg acg gag gcc aat ggc aag ctc agc cag ttg gag      633
 Leu His Gln Thr Val Thr Glu Ala Asn Gly Lys Leu Ser Gln Leu Glu
 180                 185                 190                 195

 ttt gag aag cgg cag ctg cac agg gac ttg gag cag gcc aag gag aag      681
 Phe Glu Lys Arg Gln Leu His Arg Asp Leu Glu Gln Ala Lys Glu Lys
                 200                 205                 210

 ggg gag cgg gca gag aag ctg gag aga gag cta cag cga ctc cag gag      729
 Gly Glu Arg Ala Glu Lys Leu Glu Arg Glu Leu Gln Arg Leu Gln Glu
             215                 220                 225

 gag aac ggg agg ctg gcc agg aag gtg acc tcc ctg gag aca gcc acc      777
 Glu Asn Gly Arg Leu Ala Arg Lys Val Thr Ser Leu Glu Thr Ala Thr
         230                 235                 240

 gag aaa gtc gag gcc ctg gag cat gag agc cag ggc ctg cag ctg gag      825
 Glu Lys Val Glu Ala Leu Glu His Glu Ser Gln Gly Leu Gln Leu Glu
     245                 250                 255

 aac cgg act ctg agg aag tct ctg gac acc ttg cag aac gtg tcc ctg      873
 Asn Arg Thr Leu Arg Lys Ser Leu Asp Thr Leu Gln Asn Val Ser Leu
 260                 265                 270                 275

 cag ctt gag ggc ctg gag cgt gac aac aag cag ctg gac gca gag aac      921
 Gln Leu Glu Gly Leu Glu Arg Asp Asn Lys Gln Leu Asp Ala Glu Asn
                 280                 285                 290

 ctg gag ctg cgc agg ctg gtg gag acc atg cgc ttc acc agc acc aag      969
 Leu Glu Leu Arg Arg Leu Val Glu Thr Met Arg Phe Thr Ser Thr Lys
             295                 300                 305

 ctg gca cag atg gag agg gag aac cag cag ctg gag cgt gag aag gag     1017
 Leu Ala Gln Met Glu Arg Glu Asn Gln Gln Leu Glu Arg Glu Lys Glu
         310                 315                 320

 gag ctg agg aag aac gtg gat ctg ctc aag gcg ctg ggc aag aag tca     1065
 Glu Leu Arg Lys Asn Val Asp Leu Leu Lys Ala Leu Gly Lys Lys Ser
     325                 330                 335

 gag cgc ctg gag ctc agc tac cag agc gtg agc gct gag aac ctc cgg     1113
 Glu Arg Leu Glu Leu Ser Tyr Gln Ser Val Ser Ala Glu Asn Leu Arg
 340                 345                 350                 355

 ctg cag cag agc ctg gag agc agc agc cac aag acg cag acc ttg gag     1161
 Leu Gln Gln Ser Leu Glu Ser Ser Ser His Lys Thr Gln Thr Leu Glu
                 360                 365                 370

 agt gag ctg ggc gag ctg gag gct gag cgc cag gcg ctg cgg cgg gac     1209
 Ser Glu Leu Gly Glu Leu Glu Ala Glu Arg Gln Ala Leu Arg Arg Asp
             375                 380                 385

 ctg gag gcc ctc cgg ctg gcc aat gca cag ttg gag ggg gcc gag aag     1257
 Leu Glu Ala Leu Arg Leu Ala Asn Ala Gln Leu Glu Gly Ala Glu Lys
         390                 395                 400

 gac agg aag gcc ctg gag cag gag gtg gcc cag ctc gag aag gat aag     1305
 Asp Arg Lys Ala Leu Glu Gln Glu Val Ala Gln Leu Glu Lys Asp Lys
     405                 410                 415

 aag ctg ctg gag aag gag gcc aag cgg ctg tgg cag cag gtg gag ctc     1353
 Lys Leu Leu Glu Lys Glu Ala Lys Arg Leu Trp Gln Gln Val Glu Leu
 420                 425                 430                 435

 aag gat gca gtc ttg gac gat agc act gcc aaa ctg tcc gcc gtt gag     1401
 Lys Asp Ala Val Leu Asp Asp Ser Thr Ala Lys Leu Ser Ala Val Glu
                 440                 445                 450

 aag gag agc cgc gcg ctg gac aag gag ctg gcc cgc tgc agg gac gca     1449
 Lys Glu Ser Arg Ala Leu Asp Lys Glu Leu Ala Arg Cys Arg Asp Ala
             455                 460                 465

 gcc ggc aag ctg aag gag ctg gag aag gac aac cgg gac ctc acc aag     1497
 Ala Gly Lys Leu Lys Glu Leu Glu Lys Asp Asn Arg Asp Leu Thr Lys
         470                 475                 480

 caa gtc acc gtg cat gca agg aca ctg aca act ctg agg gag gac ctg     1545
 Gln Val Thr Val His Ala Arg Thr Leu Thr Thr Leu Arg Glu Asp Leu
     485                 490                 495

 gtg ctc gag aag ctg aag agc cag cag ctc agc agt gag ctg gac aag     1593
 Val Leu Glu Lys Leu Lys Ser Gln Gln Leu Ser Ser Glu Leu Asp Lys
 500                 505                 510                 515

 ctg agc cag gaa ctg gag aag gtc ggc ctc aac agg gag ctg ctg ttg     1641
 Leu Ser Gln Glu Leu Glu Lys Val Gly Leu Asn Arg Glu Leu Leu Leu
                 520                 525                 530

 cag gag gac gac agc ggc agt gac aca aaa tac aag att ttg gag ggc     1689
 Gln Glu Asp Asp Ser Gly Ser Asp Thr Lys Tyr Lys Ile Leu Glu Gly
             535                 540                 545

 aga aat gaa tca gca tta aaa aca aca cta gcc atg aaa gaa gaa aag     1737
 Arg Asn Glu Ser Ala Leu Lys Thr Thr Leu Ala Met Lys Glu Glu Lys
         550                 555                 560

 att gtg ctc tta gaa gca cag atg gaa gag aaa gcg agc cta aat cgc     1785
 Ile Val Leu Leu Glu Ala Gln Met Glu Glu Lys Ala Ser Leu Asn Arg
     565                 570                 575

 cag tta gag agt gag ctg cag atg ctg aag aag gag tgt gag acc ctc     1833
 Gln Leu Glu Ser Glu Leu Gln Met Leu Lys Lys Glu Cys Glu Thr Leu
 580                 585                 590                 595

 agg cag aac cag gga gag ggg cag cac ttg cag aac tct ttc aag cac     1881
 Arg Gln Asn Gln Gly Glu Gly Gln His Leu Gln Asn Ser Phe Lys His
                 600                 605                 610

 cct gcg ggg aag aca gcc gcc agt cac cag ggg aag gag gcc tgg ggg     1929
 Pro Ala Gly Lys Thr Ala Ala Ser His Gln Gly Lys Glu Ala Trp Gly
             615                 620                 625

 ccc ggc cat aag gaa gcc acc atg gag ctt ctc cga gtg aag gac cgg     1977
 Pro Gly His Lys Glu Ala Thr Met Glu Leu Leu Arg Val Lys Asp Arg
         630                 635                 640

 gcc atc gag ctg gag cgg aat aat gca gct ctg cag gct gag aag cag     2025
 Ala Ile Glu Leu Glu Arg Asn Asn Ala Ala Leu Gln Ala Glu Lys Gln
     645                 650                 655

 ctg cta aag gaa cag ctg cag cac ctg gag acc cag aac gtg acc ttc     2073
 Leu Leu Lys Glu Gln Leu Gln His Leu Glu Thr Gln Asn Val Thr Phe
 660                 665                 670                 675

 agc agc cag atc ttg aca ctg cag aaa cag agc gcc ttc ctg cag gag     2121
 Ser Ser Gln Ile Leu Thr Leu Gln Lys Gln Ser Ala Phe Leu Gln Glu
                 680                 685                 690

 cac aac acc aca ctg cag acc cag acc gcc aag ctg cag gtg gag aac     2169
 His Asn Thr Thr Leu Gln Thr Gln Thr Ala Lys Leu Gln Val Glu Asn
             695                 700                 705

 tcc acg ctg agt tcc cag agc gca gcg ctc acc gcg cag tac acg ctg     2217
 Ser Thr Leu Ser Ser Gln Ser Ala Ala Leu Thr Ala Gln Tyr Thr Leu
         710                 715                 720

 ctg cag aac cac cac acg gcc aag gag acg gag aac gaa agc ctg cag     2265
 Leu Gln Asn His His Thr Ala Lys Glu Thr Glu Asn Glu Ser Leu Gln
     725                 730                 735

 agg cag gag agg caa ctt aca gcg gcc tac gag gcc ctg ctg cag gac     2313
 Arg Gln Glu Arg Gln Leu Thr Ala Ala Tyr Glu Ala Leu Leu Gln Asp
 740                 745                 750                 755

 cac gag cac ctg ggc acg ctg cac gag cgg caa tcg gcc gag tac gag     2361
 His Glu His Leu Gly Thr Leu His Glu Arg Gln Ser Ala Glu Tyr Glu
                 760                 765                 770

 gcc ctc atc cgc cag cac agc tgc cta aag aca ctg cat cgg aat ctg     2409
 Ala Leu Ile Arg Gln His Ser Cys Leu Lys Thr Leu His Arg Asn Leu
             775                 780                 785

 gag ctg gag cac aag gag ctc ggg gag agg cac ggt gac atg ctg aag     2457
 Glu Leu Glu His Lys Glu Leu Gly Glu Arg His Gly Asp Met Leu Lys
         790                 795                 800

 cgc aag gcg gag ctg gag gag cgg gag aag gtc ttg acc act gag cga     2505
 Arg Lys Ala Glu Leu Glu Glu Arg Glu Lys Val Leu Thr Thr Glu Arg
     805                 810                 815

 gag gcg ctg cag cag gag cag agg aca aac gcc ctc gcc atg ggc gag     2553
 Glu Ala Leu Gln Gln Glu Gln Arg Thr Asn Ala Leu Ala Met Gly Glu
 820                 825                 830                 835

 aac cag agg ctg cgg ggc gag ctg gac agg gtc aat ttc ctg cac cac     2601
 Asn Gln Arg Leu Arg Gly Glu Leu Asp Arg Val Asn Phe Leu His His
                 840                 845                 850

 cag ctg aag ggg gag tac gag gag ctg cac gcc cac acc aag gag ctg     2649
 Gln Leu Lys Gly Glu Tyr Glu Glu Leu His Ala His Thr Lys Glu Leu
             855                 860                 865

 aaa acc tca ctg aac aac gcg cag ctg gag ctc aac cgc tgg cag gcc     2697
 Lys Thr Ser Leu Asn Asn Ala Gln Leu Glu Leu Asn Arg Trp Gln Ala
         870                 875                 880

 cgc ttc gac gag ctg aag gag cag cac cag acc atg gac atc tcg ctg     2745
 Arg Phe Asp Glu Leu Lys Glu Gln His Gln Thr Met Asp Ile Ser Leu
     885                 890                 895

 acc aag ctg gac aac cac tgt gag ctg ctc tcc cgt ctc aag ggg aac     2793
 Thr Lys Leu Asp Asn His Cys Glu Leu Leu Ser Arg Leu Lys Gly Asn
 900                 905                 910                 915

 ttg gag gaa gaa aat cat cac ctc ctg agc cag atc cag ctg ttg agc     2841
 Leu Glu Glu Glu Asn His His Leu Leu Ser Gln Ile Gln Leu Leu Ser
                 920                 925                 930

 cag cag aac cag atg ctt ctg gag cag aac atg gag aac aag gag cag     2889
 Gln Gln Asn Gln Met Leu Leu Glu Gln Asn Met Glu Asn Lys Glu Gln
             935                 940                 945

 tac cat gag gag cag aag cag tac ata gac aaa tta aat gcc tta cga     2937
 Tyr His Glu Glu Gln Lys Gln Tyr Ile Asp Lys Leu Asn Ala Leu Arg
         950                 955                 960

 aga cat aag gaa aag ctg gaa gaa aaa atc atg gat caa tac aag ttc     2985
 Arg His Lys Glu Lys Leu Glu Glu Lys Ile Met Asp Gln Tyr Lys Phe
     965                 970                 975

 tat gat cct cct cca aag aag aag aac cac tgg att gga gcc aaa gcc     3033
 Tyr Asp Pro Pro Pro Lys Lys Lys Asn His Trp Ile Gly Ala Lys Ala
 980                 985                 990                 995

 tta gtc aaa ctc atc aaa cca aag aaa gag ggt tcg agg gaa cgc tta     3081
 Leu Val Lys Leu Ile Lys Pro Lys Lys Glu Gly Ser Arg Glu Arg Leu
                1000                1005                1010

 aaa tcc acc gtg gac agc cct ccc tgg cag ctg gag tcc tca gac ccc     3129
 Lys Ser Thr Val Asp Ser Pro Pro Trp Gln Leu Glu Ser Ser Asp Pro
            1015                1020                1025

 gcc tcg ccg gcg gcc tct cag ccg ctc aga tca cag gcc gag aac ccc     3177
 Ala Ser Pro Ala Ala Ser Gln Pro Leu Arg Ser Gln Ala Glu Asn Pro
        1030                1035                1040

 gac acc ccc gca ctg ggc tcc aac tgt gca gaa gag cgc gac gcc cac     3225
 Asp Thr Pro Ala Leu Gly Ser Asn Cys Ala Glu Glu Arg Asp Ala His
    1045                1050                1055

 aac ggg tct gtg ggg aaa ggc cct ggg gat cta aaa cca aag cga ggc     3273
 Asn Gly Ser Val Gly Lys Gly Pro Gly Asp Leu Lys Pro Lys Arg Gly
1060                1065                1070                1075

 tcc cca cac aga ggc agc ctt gac cgc aca gat gcc tcc acc gat ctg     3321
 Ser Pro His Arg Gly Ser Leu Asp Arg Thr Asp Ala Ser Thr Asp Leu
                1080                1085                1090

 gcc atg agg tcc tgg ccc tcg gag ctg ggc tcc cgg act tgc tca act     3369
 Ala Met Arg Ser Trp Pro Ser Glu Leu Gly Ser Arg Thr Cys Ser Thr
            1095                1100                1105

 tca gcc acc act aca gcc cct tcc aac tcc acc ccc atc gcc cgg cac     3417
 Ser Ala Thr Thr Thr Ala Pro Ser Asn Ser Thr Pro Ile Ala Arg His
        1110                1115                1120

 cca ggc cgc acc aaa ggc tat aac tca gat gac aac ctc tgt gag cca     3465
 Pro Gly Arg Thr Lys Gly Tyr Asn Ser Asp Asp Asn Leu Cys Glu Pro
    1125                1130                1135

 tcc ctg gag ttt gag gtc ccc aac cac agg cag tac gtg tcg cgg cca     3513
 Ser Leu Glu Phe Glu Val Pro Asn His Arg Gln Tyr Val Ser Arg Pro
1140                1145                1150                1155

 agt agc tta gag agc agt aga aac aca tcc agc aac agc tca cct ctt     3561
 Ser Ser Leu Glu Ser Ser Arg Asn Thr Ser Ser Asn Ser Ser Pro Leu
                1160                1165                1170

 aac cta aaa ggc tcc tcc gag cag ctc cat ggc cgg tct gag agc ttc     3609
 Asn Leu Lys Gly Ser Ser Glu Gln Leu His Gly Arg Ser Glu Ser Phe
            1175                1180                1185

 agc agc gaa gac ctg atc ccc agc agg gac ctg gcc act ttg ccc cgg     3657
 Ser Ser Glu Asp Leu Ile Pro Ser Arg Asp Leu Ala Thr Leu Pro Arg
        1190                1195                1200

 gaa gcc agc aca ccg gga cgc aac gcc ctc ggc cgc cac gag tac ccc     3705
 Glu Ala Ser Thr Pro Gly Arg Asn Ala Leu Gly Arg His Glu Tyr Pro
    1205                1210                1215

 ttg cct cgg aac ggg cct ctc cca cag gag ggt gcc cag aag agg ggc     3753
 Leu Pro Arg Asn Gly Pro Leu Pro Gln Glu Gly Ala Gln Lys Arg Gly
1220                1225                1230                1235

 aca gcc cct ccc tac gtc gga gtg cgg ccc tgc tcg gcc tcc ccc agc     3801
 Thr Ala Pro Pro Tyr Val Gly Val Arg Pro Cys Ser Ala Ser Pro Ser
                1240                1245                1250

 agt gag atg gtc acc ttg gag gag ttc ctg gag gag agc aac cgc agc     3849
 Ser Glu Met Val Thr Leu Glu Glu Phe Leu Glu Glu Ser Asn Arg Ser
            1255                1260                1265

 tcc ccc acc cat gac act ccc agt tgc cgg gat gac ctg ctg agt gac     3897
 Ser Pro Thr His Asp Thr Pro Ser Cys Arg Asp Asp Leu Leu Ser Asp
        1270                1275                1280

 tac ttc cga aag gcc agc gat ccc cca gcc atc gga ggc caa cca gga     3945
 Tyr Phe Arg Lys Ala Ser Asp Pro Pro Ala Ile Gly Gly Gln Pro Gly
    1285                1290                1295

 cca cct gcc aag aaa gaa ggg gcc aag atg ccc acc aac ttt gtg gcc     3993
 Pro Pro Ala Lys Lys Glu Gly Ala Lys Met Pro Thr Asn Phe Val Ala
1300                1305                1310                1315

 ccc acc gtc aaa atg gcc gcc ccc acc tcg gag ggg agg ccg ctg aag     4041
 Pro Thr Val Lys Met Ala Ala Pro Thr Ser Glu Gly Arg Pro Leu Lys
                1320                1325                1330

 ccc ggg cag tac gta aag cca aac ttc aga ctg act gag gcc gag gcc     4089
 Pro Gly Gln Tyr Val Lys Pro Asn Phe Arg Leu Thr Glu Ala Glu Ala
            1335                1340                1345

 cca ccc agc gtg gcc ccg aga cag gcc cag cct ccc cag agc ctg tct     4137
 Pro Pro Ser Val Ala Pro Arg Gln Ala Gln Pro Pro Gln Ser Leu Ser
        1350                1355                1360

 ctg ggc aga ccc cgg cag gct ccg gtg ccc cca gct tcc cat gca cct     4185
 Leu Gly Arg Pro Arg Gln Ala Pro Val Pro Pro Ala Ser His Ala Pro
    1365                1370                1375

 gcc agc cgc agt gcc tcc ttg agc cgg gcc ttc agc ctg gcc tca gct     4233
 Ala Ser Arg Ser Ala Ser Leu Ser Arg Ala Phe Ser Leu Ala Ser Ala
1380                1385                1390                1395

 gac ctt ctc cgg gcc agc ggg cca gag gcc tgc aaa cag gag tcc cct     4281
 Asp Leu Leu Arg Ala Ser Gly Pro Glu Ala Cys Lys Gln Glu Ser Pro
                1400                1405                1410

 cag aag ctg ggg gct cct gag gcc tta ggg ggc aga gag aca ggc agc     4329
 Gln Lys Leu Gly Ala Pro Glu Ala Leu Gly Gly Arg Glu Thr Gly Ser
            1415                1420                1425

 cac acc ctg caa agc ccc gca ccc ccc agc tcc cat agc ctg gcc cgg     4377
 His Thr Leu Gln Ser Pro Ala Pro Pro Ser Ser His Ser Leu Ala Arg
        1430                1435                1440

 gag cgg acc cca ctt gtg gga aag gct ggc agc tcc tgt cag ggc cca     4425
 Glu Arg Thr Pro Leu Val Gly Lys Ala Gly Ser Ser Cys Gln Gly Pro
    1445                1450                1455

 ggt ccc cgc agc cgg ccg ctg gac acg agg cgc ttc tcc ctg gct ccc     4473
 Gly Pro Arg Ser Arg Pro Leu Asp Thr Arg Arg Phe Ser Leu Ala Pro
1460                1465                1470                1475

 cca aag gag gag agg ctg gcc ccc ctg cat cag tct gcc aca gcc ccc     4521
 Pro Lys Glu Glu Arg Leu Ala Pro Leu His Gln Ser Ala Thr Ala Pro
                1480                1485                1490

 gcc att gcc act gca ggt gct ggt gct gct gct gct ggc agt ggc agc     4569
 Ala Ile Ala Thr Ala Gly Ala Gly Ala Ala Ala Ala Gly Ser Gly Ser
            1495                1500                1505

 aac tcc cag ctc ctg cac ttc tca cct gct gca gcc ccg gct gcc agg     4617
 Asn Ser Gln Leu Leu His Phe Ser Pro Ala Ala Ala Pro Ala Ala Arg
        1510                1515                1520

 acc aag ccc aag gcg ccc cca cgc tca ggg gag gtg gcc acc atc acc     4665
 Thr Lys Pro Lys Ala Pro Pro Arg Ser Gly Glu Val Ala Thr Ile Thr
    1525                1530                1535

 cct gtc cgg gca ggg ctc agc ctc tca gag gga gac ggg gtc ccg ggg     4713
 Pro Val Arg Ala Gly Leu Ser Leu Ser Glu Gly Asp Gly Val Pro Gly
1540                1545                1550                1555

 cag ggc tgc agt gag ggg ctt ccg gcc aag agc cca ggt cgg tct ccc     4761
 Gln Gly Cys Ser Glu Gly Leu Pro Ala Lys Ser Pro Gly Arg Ser Pro
                1560                1565                1570

 gat ttg gct ccc cac ctc ggc cgg gcc ctg gag gac tgc agt cga ggg     4809
 Asp Leu Ala Pro His Leu Gly Arg Ala Leu Glu Asp Cys Ser Arg Gly
            1575                1580                1585

 agc gtc tca aag agc agt ccg gcc tcc ccg gag ccc ggc ggg gat ccg     4857
 Ser Val Ser Lys Ser Ser Pro Ala Ser Pro Glu Pro Gly Gly Asp Pro
        1590                1595                1600

 cag acc gtg tgg tat gag tac ggc tgt gtg tga ctgtctcg tggttgagct     4908
 Gln Thr Val Trp Tyr Glu Tyr Gly Cys Val 
    1605                1610

 cgcaaacctg aaaactactg acgcgccttc cgactctcac ggccttttct cttgcttgcc   4968

 tgcggtgcca ggagagggtt tggaatgagg aaaggggttc ccacgcattt ctgctgtttg   5028

 ttctgtgaat ggaaacactg tgccaagccc caagaggatt acgcttccag gtgtgtaacg   5088

 tgttttctgt gtctgccgct tccagcagct gatatctttg gaacaaataa tccacgtcag   5148

 catggggacc aattcggatg caatgacaaa ctgacttccc ccaaagcaga cactactcca   5208

 gtatgtccca gtagaacact catttgcaat gtgttgagct ccgttaagca cacacacact   5268

 cacacaacag gctcacgagg ctcaggcctg gcgggtcaga aagcccactc cctctcccaa   5328

 ggccactgga tcccaggaga agcccagact ggcgatacta caaaggtctc cagggcctgg   5388

 cagaccccag agtcaggcct gctgttaaaa agtgagagtg ctgctgttcc attcctgggg   5448

 tcccaagcac ttccctttac cccaggaccc agggcagcct gcagggcagc tggcggtggc   5508

 cttggccatt tgcccccagc ctccagctgg ctcctgagct ctgcaccagg gggtttgggg   5568

 accacacagg cacctgcctt cctagatttc cctggctcac ttttctgcaa acactggatc   5628

 tgccaggcct ggggattggg gggcaggaaa gaggccccca tccagccccc tccaggccag   5688

 tgtgcacagt gcaccgaggg gtcatccgca cagagcgagg tgcaagctcg atgtgtaacc   5748

 tggctgcggc acccgacatc cccggtctcg gggtgttgat ttatttctga ataacttttt   5808

 gggtatagaa accaattttt tttaatatat gacatgtata tgtacacact catgtgaaat   5868

 atgtatactt tggggggatc tatttatgtt ccagtgggag tcactctctt ctgtcgggaa   5928

 tcttatctgc tgctttgtgt ctttggtcag attcctgaca atttagtttc ctgttgtaaa   5988

 ggtgcttttc ctggggtgaa ctaaacctat tgattttttt tttttaagat ttttttttcc   6048

 ttttgattta atatactgag aaagaaatgg gagacttttg aatgttaaca agatccattt   6108

 taggagtgtt tggggttgtg tattaaatag ccattcattc tggaactcaa ggacaggact   6168

 gtaataaaat ggaatggaac cgaaaaaaaa aaaa                               6202




      <210> 119
      <211> 2844
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(2048)

      <400> 119
 agcgcgtggc tgggcgtcag cgcggtggcc agcgcgcaga ggcgggcgcg gaggcggcta     60

 gaaggtgacc gcggatccca gcttcctgca gccagccctg aagg atg gct gcc ata     116
                                                  Met Ala Ala Ile
                                                    1

 ttg gga gac acc atc atg gtg gct aaa ggc ctt gtc aag ctg acc cag      164
 Leu Gly Asp Thr Ile Met Val Ala Lys Gly Leu Val Lys Leu Thr Gln
   5                  10                  15                  20

 gcg gcc gtg gaa acc cac ctg cag cac ttg ggc atc gga ggg gag ctg      212
 Ala Ala Val Glu Thr His Leu Gln His Leu Gly Ile Gly Gly Glu Leu
                  25                  30                  35

 atc atg gcg gcc agg gcc ctg cag tcc acg gct gtg gag cag att ggc      260
 Ile Met Ala Ala Arg Ala Leu Gln Ser Thr Ala Val Glu Gln Ile Gly
              40                  45                  50

 atg ttc ttg ggg aag gtg cag ggt cag gat aaa cat gaa gaa tat ttt      308
 Met Phe Leu Gly Lys Val Gln Gly Gln Asp Lys His Glu Glu Tyr Phe
          55                  60                  65

 gct gag aac ttc ggc ggc cca gaa ggg gag ttc cac ttc tca gtc ccg      356
 Ala Glu Asn Phe Gly Gly Pro Glu Gly Glu Phe His Phe Ser Val Pro
      70                  75                  80

 cat gca gcc gga gcc tcc aca gac ttc tct tca gcc tcc gct ccc gac      404
 His Ala Ala Gly Ala Ser Thr Asp Phe Ser Ser Ala Ser Ala Pro Asp
  85                  90                  95                 100

 cag tca gcg ccc cca tcc ctg ggt cat gcc cac agc gag ggc cca gct      452
 Gln Ser Ala Pro Pro Ser Leu Gly His Ala His Ser Glu Gly Pro Ala
                 105                 110                 115

 cct gcc tac gtg gcc agt gga ccc ttt aga gaa gcc ggg ttc ccc ggc      500
 Pro Ala Tyr Val Ala Ser Gly Pro Phe Arg Glu Ala Gly Phe Pro Gly
             120                 125                 130

 cag gcc tcc tcc cct ctg ggc agg gcc aac ggg agg ctc ttt gca aac      548
 Gln Ala Ser Ser Pro Leu Gly Arg Ala Asn Gly Arg Leu Phe Ala Asn
         135                 140                 145

 ccc aga gac tca ttc tct gcc atg ggc ttt cag cga agg ttc ttc cac      596
 Pro Arg Asp Ser Phe Ser Ala Met Gly Phe Gln Arg Arg Phe Phe His
     150                 155                 160

 cag gac caa tcc cct gtt ggg ggc ctc aca gcc gag gac att gag aag      644
 Gln Asp Gln Ser Pro Val Gly Gly Leu Thr Ala Glu Asp Ile Glu Lys
 165                 170                 175                 180

 gcc cgg cag gct aag gct cgc ccc gag aac aag cag cac aaa cag acg      692
 Ala Arg Gln Ala Lys Ala Arg Pro Glu Asn Lys Gln His Lys Gln Thr
                 185                 190                 195

 ctc agc gag cat gcc cgg gag cgg aag gtg cct gtg acg agg att ggc      740
 Leu Ser Glu His Ala Arg Glu Arg Lys Val Pro Val Thr Arg Ile Gly
             200                 205                 210

 cgg ctg gcc aac ttc gga ggt ctg gcc gtg ggc ctg ggc ttc ggg gca      788
 Arg Leu Ala Asn Phe Gly Gly Leu Ala Val Gly Leu Gly Phe Gly Ala
         215                 220                 225

 ctg gca gag gtc gcc aag aag agc ctg cgc tcc gag gac ccc tca ggg      836
 Leu Ala Glu Val Ala Lys Lys Ser Leu Arg Ser Glu Asp Pro Ser Gly
     230                 235                 240

 aag aag gcc gtg ctg ggt tcc agt cct ttc ctg tcc gag gcc aat gca      884
 Lys Lys Ala Val Leu Gly Ser Ser Pro Phe Leu Ser Glu Ala Asn Ala
 245                 250                 255                 260

 gag cgg atc gtg cgc acg ctc tgc aag gtg cgt ggt gcg gca ctc aag      932
 Glu Arg Ile Val Arg Thr Leu Cys Lys Val Arg Gly Ala Ala Leu Lys
                 265                 270                 275

 ctg ggc cag atg ctg agc atc cag gat gat gcc ttt atc aac ccc cac      980
 Leu Gly Gln Met Leu Ser Ile Gln Asp Asp Ala Phe Ile Asn Pro His
             280                 285                 290

 ctg gct aag atc ttc gag cgg gtg cgg cag agc gcg gac ttc atg cca     1028
 Leu Ala Lys Ile Phe Glu Arg Val Arg Gln Ser Ala Asp Phe Met Pro
         295                 300                 305

 ctg aag cag atg atg aaa act ctc aac aac gac ctg ggc ccc aac tgg     1076
 Leu Lys Gln Met Met Lys Thr Leu Asn Asn Asp Leu Gly Pro Asn Trp
     310                 315                 320

 cgg gac aag ttg gaa tac ttc gag gag cgg ccc ttc gcc gcc gca tcc     1124
 Arg Asp Lys Leu Glu Tyr Phe Glu Glu Arg Pro Phe Ala Ala Ala Ser
 325                 330                 335                 340

 att ggg cag gtg cac ttg gcc cga atg aag ggc ggc cgc gag gtg gcc     1172
 Ile Gly Gln Val His Leu Ala Arg Met Lys Gly Gly Arg Glu Val Ala
                 345                 350                 355

 atg aag atc cag tac cct ggc gtg gcc cag agc atc aac agt gat gtc     1220
 Met Lys Ile Gln Tyr Pro Gly Val Ala Gln Ser Ile Asn Ser Asp Val
             360                 365                 370

 aac aac ctc atg gcc gtg ttg aac atg agc aac atg ctt cca gaa ggc     1268
 Asn Asn Leu Met Ala Val Leu Asn Met Ser Asn Met Leu Pro Glu Gly
         375                 380                 385

 ctg ttc ccc gag cac ctg atc gac gtg ctg agg cgg gag ctg gcc ctg     1316
 Leu Phe Pro Glu His Leu Ile Asp Val Leu Arg Arg Glu Leu Ala Leu
     390                 395                 400

 gag tgt gac tac cag cga gag gcc gcc tgt gcc cgc aag ttc agg gac     1364
 Glu Cys Asp Tyr Gln Arg Glu Ala Ala Cys Ala Arg Lys Phe Arg Asp
 405                 410                 415                 420

 ctg ctg aag ggc cac ccc ttc ttc tat gtg cct gag att gtg gat gag     1412
 Leu Leu Lys Gly His Pro Phe Phe Tyr Val Pro Glu Ile Val Asp Glu
                 425                 430                 435

 ctc tgc agc cca cat gtg ctg acc aca gag ctg gtg tct ggc ttc ccc     1460
 Leu Cys Ser Pro His Val Leu Thr Thr Glu Leu Val Ser Gly Phe Pro
             440                 445                 450

 ctg gac cag gcc gaa ggg ctc agc cag gag att cgg aac gag atc tgc     1508
 Leu Asp Gln Ala Glu Gly Leu Ser Gln Glu Ile Arg Asn Glu Ile Cys
         455                 460                 465

 tac aac atc ctg gtt ctg tgc ctg agg gag ctg ttt gag ttc cac ttc     1556
 Tyr Asn Ile Leu Val Leu Cys Leu Arg Glu Leu Phe Glu Phe His Phe
     470                 475                 480

 atg caa aca gac ccc aac tgg tcc aac ttc ttc tat gac ccc cag cag     1604
 Met Gln Thr Asp Pro Asn Trp Ser Asn Phe Phe Tyr Asp Pro Gln Gln
 485                 490                 495                 500

 cac aag gtg gct ctt ttg gat ttt ggg gca acg cgg gaa tat gac aga     1652
 His Lys Val Ala Leu Leu Asp Phe Gly Ala Thr Arg Glu Tyr Asp Arg
                 505                 510                 515

 tcc ttc acc gac ctc tac att cag atc atc agg gct gct gcc gac agg     1700
 Ser Phe Thr Asp Leu Tyr Ile Gln Ile Ile Arg Ala Ala Ala Asp Arg
             520                 525                 530

 gac agg gag act gtg cgg gcg aaa tcc ata gag atg aag ttc ctc acc     1748
 Asp Arg Glu Thr Val Arg Ala Lys Ser Ile Glu Met Lys Phe Leu Thr
         535                 540                 545

 ggc tac gag gtc aag gtc atg gaa gac gcc cac ttg gat gcc atc ctc     1796
 Gly Tyr Glu Val Lys Val Met Glu Asp Ala His Leu Asp Ala Ile Leu
     550                 555                 560

 atc ctg ggg gag gcc ttc gcc tcc gat gag cct ttt gat ttt ggc act     1844
 Ile Leu Gly Glu Ala Phe Ala Ser Asp Glu Pro Phe Asp Phe Gly Thr
 565                 570                 575                 580

 cag agc acc acc gag aag atc cac aac ctg att ccc gtc atg ctg agg     1892
 Gln Ser Thr Thr Glu Lys Ile His Asn Leu Ile Pro Val Met Leu Arg
                 585                 590                 595

 cac cgt ctc gtc ccc cca ccc gag gaa acc tac tcc ctg cac agg aag     1940
 His Arg Leu Val Pro Pro Pro Glu Glu Thr Tyr Ser Leu His Arg Lys
             600                 605                 610

 atg ggg ggc tcc ttc ctc atc tgc tcc aag ctg aag gcc cgc ttc ccc     1988
 Met Gly Gly Ser Phe Leu Ile Cys Ser Lys Leu Lys Ala Arg Phe Pro
         615                 620                 625

 tgc aag gcc atg ttc gag gag gcc tac agc aac tac tgc aag agg cag     2036
 Cys Lys Ala Met Phe Glu Glu Ala Tyr Ser Asn Tyr Cys Lys Arg Gln
     630                 635                 640

 gcc cag cag tag ggc tgcgggccac gcccaggccg gctccgcggg aactctctcc     2091
 Ala Gln Gln 
 645

 ctcagacagg ccaaaaacca gtagcgaggt cgtggtgatg ctctttttaa ctcctttgcc   2151

 caataagggg ggtggctgcc tggagccccg tagccagcgc tttccacggt ttctgttgct   2211

 aaatggttgt agggtgagaa gtgcaagaat gaagatgaag ccccactgct cggtcagtct   2271

 gcctccgtgt gtcctctgaa ataagcagat gaagatgaaa gggcaacttt gttttcttct   2331

 ttttcctgat gtgaatgtta agcagaaggg agagagtcct tactcccttc caatctctgt   2391

 tcagtgcaaa acccagaaac atgaacagat acgattgtgg gatttttatc atctgtgtag   2451

 taggtgtgtg tatgtgtttc tagagtgaga tttgtgtttt ctgccctttt cctctccagc   2511

 cgatgggctg gagctgggag aggtgctgag ctaacagtgc caacaagtgc tccttaagcc   2571

 tgcgaggccc aggcctgtgg ggctggttct cacctttgac agctgaatgt tcctaaagaa   2631

 ctgctgcccc acagtgaggg tgggagcagc ggaacaggga atgccagaca caggctcgct   2691

 gctgctggaa ggcggggtgg gacttccttc ctctgtccgg agaggcacag gtgtcaccag   2751

 ttccagccaa aggctcctca caggcgctgt gaatttttgt acaagtcttg taattatcga   2811

 atcaacaact tgttgcaatt ttaattaaaa ttg                                2844




      <210> 120
      <211> 4179
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (482)..(2284)

      <400> 120
 tggagacgtt tcagctccac accattcagt atgggagacg ccagccccac ggggctacgg     60

 tgcaagcaga taactgaatt tcgaagtgcc tcctctgggc ttctcccagc tgcctttgtg    120

 tcctctatcc cagctcccat cacccctggt cacacaatcc acctcctcct ttggacttcg    180

 agctccgtgt cggtggatag tgtggctttg ctggggtccc ggctgtgtcc ccagcaccca    240

 ccacacggct ggcacacagg ctccgcgagc gccggacgga cggactacaa ttcccgacag    300

 gcagcgcggc tggcggggcg gttcgccgcg gtgcccacag gacctcaggg cgagtgcggg    360

 ctgccccgcg cggcgcccgc aggaccccgg cggctaccca tgccgaggtg agtccgcggg    420

 agccgccgcc gccgccgtcc cgtcccagct gccgccccgc gcggccccgc cgccggccag    480

 g    atg ctg gag gaa gcg ggc gag gtg ctg gag aac atg ctg aag gcg     526
      Met Leu Glu Glu Ala Gly Glu Val Leu Glu Asn Met Leu Lys Ala
        1               5                  10                  15

 tct tgt ctg ccg ctc ggc ttc atc gtc ttc ctg ccc gct gtg ctg ctg      574
 Ser Cys Leu Pro Leu Gly Phe Ile Val Phe Leu Pro Ala Val Leu Leu
                  20                  25                  30

 ctg gtg gcg ccg ccg ctg cct gcc gcc gac gcc gcg cac gag ttc acc      622
 Leu Val Ala Pro Pro Leu Pro Ala Ala Asp Ala Ala His Glu Phe Thr
              35                  40                  45

 gtg tac cgc atg cag cag tac gac ctg cag ggc cag ccc tac ggc aca      670
 Val Tyr Arg Met Gln Gln Tyr Asp Leu Gln Gly Gln Pro Tyr Gly Thr
          50                  55                  60

 cgg aat gca gtg ctg aac acg gag gcg cgc acg atg gcg gcg gag gtg      718
 Arg Asn Ala Val Leu Asn Thr Glu Ala Arg Thr Met Ala Ala Glu Val
      65                  70                  75

 ctg agc cgc cgc tgc gtg ctc atg cgg cta ctg gac ttc tcc tac gag      766
 Leu Ser Arg Arg Cys Val Leu Met Arg Leu Leu Asp Phe Ser Tyr Glu
  80                  85                  90                  95

 cag tac cag aag gcc ctg cgg cag tcg gcg ggc gcc gtg gtc atc atc      814
 Gln Tyr Gln Lys Ala Leu Arg Gln Ser Ala Gly Ala Val Val Ile Ile
                 100                 105                 110

 ctg ccc agg gcc atg gcc gcc gtg ccc cag gac gtc gtc cgg gga cag      862
 Leu Pro Arg Ala Met Ala Ala Val Pro Gln Asp Val Val Arg Gly Gln
             115                 120                 125

 tca ctg ggc ccc ctg cta ccc cca cca ggg aca gtc act ggg ccc cct      910
 Ser Leu Gly Pro Leu Leu Pro Pro Pro Gly Thr Val Thr Gly Pro Pro
         130                 135                 140

 gct acc ttg cca ccc cca cca ggc cag cag ccc cct aag tgt gtg tct      958
 Ala Thr Leu Pro Pro Pro Pro Gly Gln Gln Pro Pro Lys Cys Val Ser
     145                 150                 155

 gct cca cag caa ttc atg gag atc gag ccg gag atg ctg gcc atg gag     1006
 Ala Pro Gln Gln Phe Met Glu Ile Glu Pro Glu Met Leu Ala Met Glu
 160                 165                 170                 175

 acc gcc gtc ccc gtg tac ttt gcc gtg gag gac gag gcc ctg ctg tct     1054
 Thr Ala Val Pro Val Tyr Phe Ala Val Glu Asp Glu Ala Leu Leu Ser
                 180                 185                 190

 atc tac aag cag acc cag gct gcc tcc gcc tcc cag ggc tcc gcc tct     1102
 Ile Tyr Lys Gln Thr Gln Ala Ala Ser Ala Ser Gln Gly Ser Ala Ser
             195                 200                 205

 gct gct gaa gta ctg ctg cgc acg gcc act gcc aac ggc ttc cag atg     1150
 Ala Ala Glu Val Leu Leu Arg Thr Ala Thr Ala Asn Gly Phe Gln Met
         210                 215                 220

 gtc acc agc ggg gta cag agc aag gcc gtg agt gac tgg ctg att gcc     1198
 Val Thr Ser Gly Val Gln Ser Lys Ala Val Ser Asp Trp Leu Ile Ala
     225                 230                 235

 agc gtg gag ggg cgg ctg acg ggg ctg ggc gga gag gac ctt ccc acc     1246
 Ser Val Glu Gly Arg Leu Thr Gly Leu Gly Gly Glu Asp Leu Pro Thr
 240                 245                 250                 255

 atc gtc atc gtg gcc cac tac gac gcc ttt gga gtg gcc ccc tgg ctg     1294
 Ile Val Ile Val Ala His Tyr Asp Ala Phe Gly Val Ala Pro Trp Leu
                 260                 265                 270

 tcg ctg ggc gcg gac tcc aac ggg agc ggc gtc tct gtg ctg ctg gag     1342
 Ser Leu Gly Ala Asp Ser Asn Gly Ser Gly Val Ser Val Leu Leu Glu
             275                 280                 285

 ctg gca cgc ctc ttc tcc cgg ctc tac acc tac aag cgc acg cac gcc     1390
 Leu Ala Arg Leu Phe Ser Arg Leu Tyr Thr Tyr Lys Arg Thr His Ala
         290                 295                 300

 gcc tac aac ctc ctg ttc ttt gcg tct gga gga ggc aag ttt aac tac     1438
 Ala Tyr Asn Leu Leu Phe Phe Ala Ser Gly Gly Gly Lys Phe Asn Tyr
     305                 310                 315

 cag gga acc aag cgc tgg ctg gaa gac aac ctg gac cac aca gac tcc     1486
 Gln Gly Thr Lys Arg Trp Leu Glu Asp Asn Leu Asp His Thr Asp Ser
 320                 325                 330                 335

 agc ctg ctt cag gac aat gtg gcc ttc gtg ctg tgc ctg gac acc gtg     1534
 Ser Leu Leu Gln Asp Asn Val Ala Phe Val Leu Cys Leu Asp Thr Val
                 340                 345                 350

 ggc cgg ggc agc agc ctg cac ctg cac gtg tcc aag ccg cct cgg gag     1582
 Gly Arg Gly Ser Ser Leu His Leu His Val Ser Lys Pro Pro Arg Glu
             355                 360                 365

 ggc acc ctg cag cac gcc ttc ctg cgg gag ctg gag acg gtg gcc gcg     1630
 Gly Thr Leu Gln His Ala Phe Leu Arg Glu Leu Glu Thr Val Ala Ala
         370                 375                 380

 cac cag ttc cct gag gta cgg ttc tcc atg gtg cac aag cgg atc aac     1678
 His Gln Phe Pro Glu Val Arg Phe Ser Met Val His Lys Arg Ile Asn
     385                 390                 395

 ctg gcg gag gac gtg ctg gcc tgg gag cac gag cgc ttc gcc atc cgc     1726
 Leu Ala Glu Asp Val Leu Ala Trp Glu His Glu Arg Phe Ala Ile Arg
 400                 405                 410                 415

 cga ctg ccc gcc ttc acg ctg tcc cac ctg gag agc cac cgt gac ggc     1774
 Arg Leu Pro Ala Phe Thr Leu Ser His Leu Glu Ser His Arg Asp Gly
                 420                 425                 430

 cag cgc agc agc atc atg gac gtg cgg tcc cgg gtg gat tct aag acc     1822
 Gln Arg Ser Ser Ile Met Asp Val Arg Ser Arg Val Asp Ser Lys Thr
             435                 440                 445

 ctg acc cgt aac acg agg atc att gca gag gcc ctg act cga gtc atc     1870
 Leu Thr Arg Asn Thr Arg Ile Ile Ala Glu Ala Leu Thr Arg Val Ile
         450                 455                 460

 tac aac ctg aca gag aag ggg aca ccc cca gac atg ccg gtg ttc aca     1918
 Tyr Asn Leu Thr Glu Lys Gly Thr Pro Pro Asp Met Pro Val Phe Thr
     465                 470                 475

 gag cag atg cag atc cag cag gag cag ctg gac tcg gtg atg gac tgg     1966
 Glu Gln Met Gln Ile Gln Gln Glu Gln Leu Asp Ser Val Met Asp Trp
 480                 485                 490                 495

 ctc acc aac cag ccg cgg gcc gcg cag ctg gtg gac aag gac agc acc     2014
 Leu Thr Asn Gln Pro Arg Ala Ala Gln Leu Val Asp Lys Asp Ser Thr
                 500                 505                 510

 ttc ctc agc acg ctg gag cac cac ctg agc cgc tac ctg aag gac gtg     2062
 Phe Leu Ser Thr Leu Glu His His Leu Ser Arg Tyr Leu Lys Asp Val
             515                 520                 525

 aag cag cac cac gtc aag gct gac aag cgg gac cca gag ttt gtc ttc     2110
 Lys Gln His His Val Lys Ala Asp Lys Arg Asp Pro Glu Phe Val Phe
         530                 535                 540

 tac gac cag ctg aag caa gtg atg aat gcg tac aga gtc aag ccg gcc     2158
 Tyr Asp Gln Leu Lys Gln Val Met Asn Ala Tyr Arg Val Lys Pro Ala
     545                 550                 555

 gtc ttt gac ctg ctc ctg gct gtt ggc att gct gcc tac ctc ggc atg     2206
 Val Phe Asp Leu Leu Leu Ala Val Gly Ile Ala Ala Tyr Leu Gly Met
 560                 565                 570                 575

 gcc tac gtg gct gtc cag cac ttc agc ctc ctc tac aag acc gtc cag     2254
 Ala Tyr Val Ala Val Gln His Phe Ser Leu Leu Tyr Lys Thr Val Gln
                 580                 585                 590

 agg ctg ctc gtg aag gcc aag aca cag tga c acagccaccc ccacagccgg     2305
 Arg Leu Leu Val Lys Ala Lys Thr Gln 
             595                 600

 agcccccgcc gctccacagt ccctggggcc gagcacgagt gagtggacac tgccccgccg   2365

 cgggcggccc tgcagggaca ggggccctct ccctccccgg cggtggttgg aacactgaat   2425

 tacagagctt ttttctgttg ctctccgaga ctgggggggg attgtttctt cttttccttg   2485

 tctttgaact tccttggagg agagcttggg agacgtcccg gggccaggct acggacttgc   2545

 ggacgagccc cccagtcctg ggagccggcc gccctcggtc tggtgtaagc acacatgcac   2605

 gattaaagag gagacgccgg gaccccctgc ccgatcgcgc gcgggctccg cccaccgcct   2665

 cctgccgcaa ggggcctgga ctgcaggcct gacctgctcc ctgctccgtg tctgtcctag   2725

 gacgtcccct cccgctcccc gatggtggcg tggacatggt tatttatctc tgctccttct   2785

 tgcctggagg agggcagtgc cagccctggg gttctgggat tccagccctc ctggagcctt   2845

 ttgttcccca tgtggtctca gtgacccgtc cccctgacag tgggctcggg gagctgcatc   2905

 acccagcctt ccccttctcc gactgcaggg tctgatgtca tcgttgacag cctttgcttc   2965

 gtgggggcct ggcagggccc ctgcctcccc gacccccgac ccactgcaaa cccccgttcc   3025

 cctgcactcc tcttctccca gcccatccct ccggcccctg tgcctctgcg gccccagccc   3085

 agctcccagg gccgtcacct gcttggccct ggcccagctc cctgccctga gtcctgagcc   3145

 agtgcctggt gtttcctggg ctcggtactg ggcccccagg ccatccaggc tttgccacgg   3205

 ccagttggtc ctccctgggg aactgggtgc gggtggagta ctgggaggca ggaggtggcc   3265

 cggggaggcc ttgtggctcc tcccctcgct cctcgccctg ggcctcagct tcctcatcaa   3325

 tagaaaggat gtgttcgggg tgggggcgtc aggtgagaac gtttgctggg aaggagagga   3385

 cttggggcat ggcctctggg gccacccttc ctggaactca gagaggaagg tccgggccct   3445

 cgggaagcct tggacagaac cctccacccc gcagaccagg cgtcgtgtgt gtgtgggaga   3505

 gaaggaggcc cgtgttgagc tcagggagac cccggtgtgt ccgttcttta gcaatataac   3565

 ctacccagtg cgtgccgagc aggcttggtg gggaagggac ttgagctggg caagtcctgg   3625

 cctggcaccc gcagccgtct cccttccgtg gcccagggag gtgtttgctg tccgaaggac   3685

 ctgggccggc ccatgggagc ctggggttct gtccagatag gaccaggggg tctcactttg   3745

 gccaccagtt cttcggccag cacctctgcc ctccagaacc tgcagcctgg aggggtgagg   3805

 ggacaaccac ccctctttcc tccaggttgg caggggaccc tcttctcccg tctgccctgc   3865

 gggttgcccg cctcctccag agacttgccc aagggcccat caccactggc ctctgggcac   3925

 ttgtgctgag actctgggac ccaggcagct gccaccttgt caccatgaga gaatttgggg   3985

 agtgcttgca tgctagccag caggctcctg tctgggtgcc acggggccag cattttggag   4045

 ggagcttcct tccttccttc ctggacaggt cgtcaggatg gatgcactga ctgaccgtct   4105

 ggggctcagg ctggtgtggg atgcagccgg ccgatgagaa aataaagcca tattgaatga   4165

 tcaaaaaaaa aaaa                                                     4179




      <210> 121
      <211> 2511
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (142)..(1365)

      <400> 121
 gattttctgc tccggttggt gagcgcgcct gcgcgttgac ggcgattttg cgttctgagg     60

 ctgcagcgtc ggcatcttga gctgccggtt cgcgagttcg aggccaggtt ccgcctgtcg    120

 tgggttcgca ccccggacgc g  atg cta ttc gac aag gtg aaa gcg ttc tcg     171
                          Met Leu Phe Asp Lys Val Lys Ala Phe Ser
                            1               5                  10

 gtg cag ttg gac ggc gcg acc gcg ggc gtc gag ccc gtg ttt agc ggc      219
 Val Gln Leu Asp Gly Ala Thr Ala Gly Val Glu Pro Val Phe Ser Gly
                  15                  20                  25

 ggc cag gcc gtg gcg ggc cgg gtg ctg ctg gag ctg tca agc gcc gcg      267
 Gly Gln Ala Val Ala Gly Arg Val Leu Leu Glu Leu Ser Ser Ala Ala
              30                  35                  40

 cgt gtg ggt gcc ctg agg ctg cgc gcg cgg ggc cgc gcc cac gtg cac      315
 Arg Val Gly Ala Leu Arg Leu Arg Ala Arg Gly Arg Ala His Val His
          45                  50                  55

 tgg acc gag tcg cgc agc gcg ggc tcg agc acg gct tac acg cag agc      363
 Trp Thr Glu Ser Arg Ser Ala Gly Ser Ser Thr Ala Tyr Thr Gln Ser
      60                  65                  70

 tac agt gaa cgc gtg gag gtc gtg agc cac cgc gcc acg ctc ctg gcg      411
 Tyr Ser Glu Arg Val Glu Val Val Ser His Arg Ala Thr Leu Leu Ala
  75                  80                  85                  90

 cca gat acc ggg gag acc acg acg ctg cct cct ggg cgc cat gag ttc      459
 Pro Asp Thr Gly Glu Thr Thr Thr Leu Pro Pro Gly Arg His Glu Phe
                  95                 100                 105

 ctg ttc agc ttc cag ctg ccc ccg acc ctg gtg aca tcc ttc gag ggc      507
 Leu Phe Ser Phe Gln Leu Pro Pro Thr Leu Val Thr Ser Phe Glu Gly
             110                 115                 120

 aaa cac ggt agt gtc cgc tac tgt atc aag gcc acc ctg cac cgg ccc      555
 Lys His Gly Ser Val Arg Tyr Cys Ile Lys Ala Thr Leu His Arg Pro
         125                 130                 135

 tgg gtc cca gca cgc cgg gca agg aag gtg ttc act gtc atc gag cct      603
 Trp Val Pro Ala Arg Arg Ala Arg Lys Val Phe Thr Val Ile Glu Pro
     140                 145                 150

 gtg gac atc aac acg cca gcc ctg ctg gca cct caa gcg ggg gct cgg      651
 Val Asp Ile Asn Thr Pro Ala Leu Leu Ala Pro Gln Ala Gly Ala Arg
 155                 160                 165                 170

 gaa aag gtt gcc cga tcc tgg tac tgt aac cgt ggc cta gtc tcc ctt      699
 Glu Lys Val Ala Arg Ser Trp Tyr Cys Asn Arg Gly Leu Val Ser Leu
                 175                 180                 185

 tcg gcc aag atc gac cgc aag ggc tac acc cca gga gag gtc atc cct      747
 Ser Ala Lys Ile Asp Arg Lys Gly Tyr Thr Pro Gly Glu Val Ile Pro
             190                 195                 200

 gtc ttt gcc gag atc gac aac ggc tcc aca cgt cct gtg ctg cct cgg      795
 Val Phe Ala Glu Ile Asp Asn Gly Ser Thr Arg Pro Val Leu Pro Arg
         205                 210                 215

 gca gcc gtg gtg cag aca cag acg ttc atg gcc cga ggc gcc cga aag      843
 Ala Ala Val Val Gln Thr Gln Thr Phe Met Ala Arg Gly Ala Arg Lys
     220                 225                 230

 cag aaa cgg gca gtg gtg gcc agc ctc gcg ggc gag ccg gtg ggc ccc      891
 Gln Lys Arg Ala Val Val Ala Ser Leu Ala Gly Glu Pro Val Gly Pro
 235                 240                 245                 250

 ggg cag cgg gcg ctg tgg cag ggc cgg gca ctg cgg atc ccc cca gtg      939
 Gly Gln Arg Ala Leu Trp Gln Gly Arg Ala Leu Arg Ile Pro Pro Val
                 255                 260                 265

 ggt cct tcc atc ctg cac tgc cgc gtt cta cac gtg gac tac gca ctc      987
 Gly Pro Ser Ile Leu His Cys Arg Val Leu His Val Asp Tyr Ala Leu
             270                 275                 280

 aag gtc tgt gtg gat atc cca gga acg tcc aag ctg ctg ctg gag ctg     1035
 Lys Val Cys Val Asp Ile Pro Gly Thr Ser Lys Leu Leu Leu Glu Leu
         285                 290                 295

 cca ctg gtg atc ggc acc att ccc ttg cac cct ttt ggc agc cgt tcc     1083
 Pro Leu Val Ile Gly Thr Ile Pro Leu His Pro Phe Gly Ser Arg Ser
     300                 305                 310

 tcc agc gtg ggc agc cac gcc agc ttc ctg ctg gac tgg agg ctg ggg     1131
 Ser Ser Val Gly Ser His Ala Ser Phe Leu Leu Asp Trp Arg Leu Gly
 315                 320                 325                 330

 gcc ttg ccg gag cgg cct gag gct cct cct gag tac tcg gag gtg gta     1179
 Ala Leu Pro Glu Arg Pro Glu Ala Pro Pro Glu Tyr Ser Glu Val Val
                 335                 340                 345

 gcc gac act gag gag gca gcc ttg ggg cag agc ccc ttc ccg ctt ccg     1227
 Ala Asp Thr Glu Glu Ala Ala Leu Gly Gln Ser Pro Phe Pro Leu Pro
             350                 355                 360

 cag gac ccc gac atg agc ctt gaa ggc ccg ttc ttc gcc tac atc caa     1275
 Gln Asp Pro Asp Met Ser Leu Glu Gly Pro Phe Phe Ala Tyr Ile Gln
         365                 370                 375

 gag ttc cgc tac cgc ccg cca ccc ctg tac tct gag gag gat cca aac     1323
 Glu Phe Arg Tyr Arg Pro Pro Pro Leu Tyr Ser Glu Glu Asp Pro Asn
     380                 385                 390

 cca ctc ttg ggg gac atg agg ccg cgc tgc atg act tgc tga acggcac     1372
 Pro Leu Leu Gly Asp Met Arg Pro Arg Cys Met Thr Cys 
 395                 400                 405

 agggacccct cgaggaacaa ggttgcacac cagctttcag ccaccatgac tgtggggagt   1432

 ggctggacca agggctgacc tccccgactg catcaaagtt ggggaaccaa gtctcagagt   1492

 gaggcggggg cctttcggat atcacatggg acagaggaag agcccggctg gaatctgact   1552

 tacctggacc gctgtccttg tgaggcattg aatgcccagt gcagtatccg agagactgtt   1612

 taataacctg tcttcccagc caattggtgg tgctggaatc ccctaggagc cttcagtctg   1672

 ggagaaacag agccagacat agacagttcc agcatcacag aaccagaaga agagacctgc   1732

 aactgtgaga gtccagacag gaagcagaga aggcgtcctt gcggaaaggg cattttagct   1792

 gaggctttgg agtacgaata ggagctcagc aggcagacga atgaggaata aaggtcagag   1852

 aaggtcagag ctgagtgacg tttggaatcc accccgttta ttgtagaact gggggttcag   1912

 agggcaggtg cctcagagtt gaggccacac agtgaggtct ggtgggtgaa aggacccagg   1972

 aacgaggcgt tcaggaaagc aggttgtcag agctatgtgg agtctgtggg tggcaggggc   2032

 agccgctcca gcctttgaag actttgaaag ccagagattc ctggcgcagg cttggacttc   2092

 ctgggagctc ctccaagtac ccaggggcat cagagctgcc tgggtgttac atggcccagg   2152

 gaacccaggt tcagggtagg acaggcaaga ccagataccc aatgtgcaaa gtgaaaacac   2212

 tgggctccct gttaaacgat gaagaattca agacagtgac agcattacgt cacccctggg   2272

 gacagaggtc agcctaaggt gacacacggg gactactgtg cttccggagg ctccctgtgt   2332

 cctggaggag aaaagcatta gagggggcag ctggacaagc tcccaactgc agagtcccag   2392

 ccctggctgg ggcagggccc cggcctggga ctcagcattt ctgatatgcc ttaagaattc   2452

 attctgtttt gtacaattat tttttaaaag taaacgtgtg gagaaagaaa aaaaaaaaa    2511




      <210> 122
      <211> 787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (56)..(673)

      <400> 122
 ggcacgaggc tcgccgtgag acagcaagtg tcggatccgc aggcgcagcc gtgcg atg      58
                                                              Met
                                                                1

 ttg tcc tct aca gcc atg tat tcg gct cct ggc aga gac ttg ggg atg      106
 Leu Ser Ser Thr Ala Met Tyr Ser Ala Pro Gly Arg Asp Leu Gly Met
               5                  10                  15

 gaa ccg cac aga gcc gcg ggc cct ttg cag ctg cga ttt tcg ccc tac      154
 Glu Pro His Arg Ala Ala Gly Pro Leu Gln Leu Arg Phe Ser Pro Tyr
          20                  25                  30

 gtt ttc aac gga gga aca gac aaa aca gtc att gga tgc agc ggt ttt      202
 Val Phe Asn Gly Gly Thr Asp Lys Thr Val Ile Gly Cys Ser Gly Phe
      35                  40                  45

 cat gga gac tgt ctt acg ctg aca aag att att gaa gca aga cta aag      250
 His Gly Asp Cys Leu Thr Leu Thr Lys Ile Ile Glu Ala Arg Leu Lys
  50                  55                  60                  65

 atg tat aag cat tcc aat aat aag gcc atg act acg ggg gca att gct      298
 Met Tyr Lys His Ser Asn Asn Lys Ala Met Thr Thr Gly Ala Ile Ala
                  70                  75                  80

 gca atg ctg tct aca atc ctg tat tca agg cgc ttc ttt cca tac tat      346
 Ala Met Leu Ser Thr Ile Leu Tyr Ser Arg Arg Phe Phe Pro Tyr Tyr
              85                  90                  95

 gtt tac aac atc atc ggt gga ctt gat gaa gaa gga aag ggg gct gta      394
 Val Tyr Asn Ile Ile Gly Gly Leu Asp Glu Glu Gly Lys Gly Ala Val
         100                 105                 110

 tac agc ttt gat cca gta ggg tct tac cag aga gac tcc ttc aag gct      442
 Tyr Ser Phe Asp Pro Val Gly Ser Tyr Gln Arg Asp Ser Phe Lys Ala
     115                 120                 125

 gga ggc tca gca agt gcc atg cta cag ccc ctg ctt gac aac cag gtt      490
 Gly Gly Ser Ala Ser Ala Met Leu Gln Pro Leu Leu Asp Asn Gln Val
 130                 135                 140                 145

 ggt ttt aag aac atg cag aat gtg gag cat gtt ccg ctg tcc ttg gac      538
 Gly Phe Lys Asn Met Gln Asn Val Glu His Val Pro Leu Ser Leu Asp
                 150                 155                 160

 aga gcc atg cgg ctg gtg aaa gat gtc ttc att tct gcg gct gag aga      586
 Arg Ala Met Arg Leu Val Lys Asp Val Phe Ile Ser Ala Ala Glu Arg
             165                 170                 175

 gat gtg tac act ggg gac gca ctc cgg atc tgc ata gtg acc aaa gag      634
 Asp Val Tyr Thr Gly Asp Ala Leu Arg Ile Cys Ile Val Thr Lys Glu
         180                 185                 190

 ggc atc agg gag gaa act gtt tcc tta agg aag gac tga tctgtgtgct       683
 Gly Ile Arg Glu Glu Thr Val Ser Leu Arg Lys Asp 
     195                 200                 205

 cttatcacca atcagttcag acctggttga ttttgtactt tggaactgta ccttggatgg    743

 ttttgtttat taaaagagaa acctgaagta aaaaaaaaaa aaaa                     787




      <210> 123
      <211> 1423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (394)..(1266)

      <400> 123
 tttcgtggcg gcgctggtga gtttggtgtg gtttcttcct cgcgtagcta ttgttgagtt     60

 gtcctttgcc ttcagcggct ggaggcaaac tgttggtacc agggaagggt ggtgatgaaa    120

 gttgcttcag ggaggcggcc tccctagagt taccgttcct gtccggtaac ccaaggggct    180

 ggctttaagg cgaatctgtg aacccgagtg tgaaggcccc gagtctgggt gtctgacgga    240

 gagagggcag tttcccaccc tagacgttcc actttcctat aatcctgagg aaagaatgac    300

 ttttctttac gcctcctctc ccttctgtag ggggtgctgg agtccgacct gccaagtgcc    360

 gtgacacttc tgaaaaatct ccaggagcaa gtg atg gct gta act gca caa gtg     414
                                      Met Ala Val Thr Ala Gln Val
                                        1               5

 aaa tca ctg aca caa aaa gtt caa gct ggt gcc tat cct aca gaa aag      462
 Lys Ser Leu Thr Gln Lys Val Gln Ala Gly Ala Tyr Pro Thr Glu Lys
          10                  15                  20

 ggt ctc agc ttc ttg gaa gtg aaa gac cag ctg ctg ctc atg tac ctt      510
 Gly Leu Ser Phe Leu Glu Val Lys Asp Gln Leu Leu Leu Met Tyr Leu
      25                  30                  35

 atg gat ttg acc cac ctc att ctg gac aaa gcc tca gga gga tct ctt      558
 Met Asp Leu Thr His Leu Ile Leu Asp Lys Ala Ser Gly Gly Ser Leu
  40                  45                  50                  55

 cag gga cat gat gca gtt ttg aga ctg gta gag att cga acg gtt ttg      606
 Gln Gly His Asp Ala Val Leu Arg Leu Val Glu Ile Arg Thr Val Leu
                  60                  65                  70

 gaa aag ctt cgt ccc ttg gac caa aag ctg aag tat caa att gac aag      654
 Glu Lys Leu Arg Pro Leu Asp Gln Lys Leu Lys Tyr Gln Ile Asp Lys
              75                  80                  85

 ctg atc aag act gca gtg aca ggc agc ctt agt gag aat gac cca ctt      702
 Leu Ile Lys Thr Ala Val Thr Gly Ser Leu Ser Glu Asn Asp Pro Leu
          90                  95                 100

 cgt ttt aag cct cat ccc agc aat atg atg agc aag ttg agc tct gag      750
 Arg Phe Lys Pro His Pro Ser Asn Met Met Ser Lys Leu Ser Ser Glu
     105                 110                 115

 gat gag gag gaa gat gaa gca gaa gat gac cag tct gag gct tca ggg      798
 Asp Glu Glu Glu Asp Glu Ala Glu Asp Asp Gln Ser Glu Ala Ser Gly
 120                 125                 130                 135

 aag aaa tct gtg aag gga gtg tct aag aaa tat gtt cct cca cgc ttg      846
 Lys Lys Ser Val Lys Gly Val Ser Lys Lys Tyr Val Pro Pro Arg Leu
                 140                 145                 150

 gtt cca gta cat tat gat gaa aca gaa gct gag cgg gag aag aag cgt      894
 Val Pro Val His Tyr Asp Glu Thr Glu Ala Glu Arg Glu Lys Lys Arg
             155                 160                 165

 cta gaa cga gcc aag aga cgg gca ttg agc agc tct gtc att cgt gaa      942
 Leu Glu Arg Ala Lys Arg Arg Ala Leu Ser Ser Ser Val Ile Arg Glu
         170                 175                 180

 ctt aag gag cag tac tca gat gct cca gag gaa atc cgt gat gct cgg      990
 Leu Lys Glu Gln Tyr Ser Asp Ala Pro Glu Glu Ile Arg Asp Ala Arg
     185                 190                 195

 cat ccc cat gtt acc cgc cag agt cag gag gac caa cac agg att aac     1038
 His Pro His Val Thr Arg Gln Ser Gln Glu Asp Gln His Arg Ile Asn
 200                 205                 210                 215

 tat gag gag agc atg atg gtg cgt ttg agc gtc agt aag cga gag aaa     1086
 Tyr Glu Glu Ser Met Met Val Arg Leu Ser Val Ser Lys Arg Glu Lys
                 220                 225                 230

 gga cgg cga aaa cga gca aat gtc atg agc tca caa ctt cat tcc ctt     1134
 Gly Arg Arg Lys Arg Ala Asn Val Met Ser Ser Gln Leu His Ser Leu
             235                 240                 245

 aca cac ttc agt gac atc agt gct ttg aca ggg gga act gtt cat ctt     1182
 Thr His Phe Ser Asp Ile Ser Ala Leu Thr Gly Gly Thr Val His Leu
         250                 255                 260

 gat gag gat cag aat cct att aag aag cgg aag aag ata cct cag aaa     1230
 Asp Glu Asp Gln Asn Pro Ile Lys Lys Arg Lys Lys Ile Pro Gln Lys
     265                 270                 275

 ggt cgg aag aaa aaa ggt ttt cgg agg cgg cgg tga ttat gggtgtacat     1280
 Gly Arg Lys Lys Lys Gly Phe Arg Arg Arg Arg 
 280                 285                 290

 atttgtatat tttttgtcat cctgagatac ttctaatttc attgtatata ggtggttttc   1340

 cctggaattc attaattgtt tgctttggac atgtggaaag agccttacta ataaaattga   1400

 ttttacttat gaaaaaaaaa aaa                                           1423




      <210> 124
      <211> 1221
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4)..(807)

      <400> 124
 aac  atg gcg gcg ccc gtt gtc acg gcc ccg ggc aga gct ctg ctg cgg      48
      Met Ala Ala Pro Val Val Thr Ala Pro Gly Arg Ala Leu Leu Arg
        1               5                  10                  15

 gcg ggc gct gga cgg ctg ctt cgg gga ggc gtc cag gag cta ctg cgg       96
 Ala Gly Ala Gly Arg Leu Leu Arg Gly Gly Val Gln Glu Leu Leu Arg
                  20                  25                  30

 ccg cga cat gaa ggg aac gcc cct gac ctg gcc tgc aac ttc agc ctt      144
 Pro Arg His Glu Gly Asn Ala Pro Asp Leu Ala Cys Asn Phe Ser Leu
              35                  40                  45

 tct caa aat cgg ggc acg gtc atc gtg gag cgc tgg tgg aag gta ccg      192
 Ser Gln Asn Arg Gly Thr Val Ile Val Glu Arg Trp Trp Lys Val Pro
          50                  55                  60

 ctg gcc ggg gag ggc cgg aag ccg cgc ctg cac cgg cga cat cgc gtc      240
 Leu Ala Gly Glu Gly Arg Lys Pro Arg Leu His Arg Arg His Arg Val
      65                  70                  75

 tat aag ctg gtg gag gac acg aag cat cgg ccc aaa gaa aac ctg gag      288
 Tyr Lys Leu Val Glu Asp Thr Lys His Arg Pro Lys Glu Asn Leu Glu
  80                  85                  90                  95

 ctc atc ctg acg cag tcg gtg gag aat gtt gga gtc cgg ggt gac ctg      336
 Leu Ile Leu Thr Gln Ser Val Glu Asn Val Gly Val Arg Gly Asp Leu
                 100                 105                 110

 gtc tca gtg aag aaa tct tta ggc cgg aat cga ctc ctt cct cag gga      384
 Val Ser Val Lys Lys Ser Leu Gly Arg Asn Arg Leu Leu Pro Gln Gly
             115                 120                 125

 ctg gct gta tat gca tcc cct gaa aac aag aag ctg ttt gaa gag gag      432
 Leu Ala Val Tyr Ala Ser Pro Glu Asn Lys Lys Leu Phe Glu Glu Glu
         130                 135                 140

 aaa ttg ctg aga caa gaa gga aaa tta gag aag atc cag acc aag gca      480
 Lys Leu Leu Arg Gln Glu Gly Lys Leu Glu Lys Ile Gln Thr Lys Ala
     145                 150                 155

 ggt gag gcg aca gtg aaa ttt cta aaa agc tgt cgc ctg gag gta ggg      528
 Gly Glu Ala Thr Val Lys Phe Leu Lys Ser Cys Arg Leu Glu Val Gly
 160                 165                 170                 175

 atg aag aac aat gtc aaa tgg gag ctg aac cct gaa ata gtt gcc cgc      576
 Met Lys Asn Asn Val Lys Trp Glu Leu Asn Pro Glu Ile Val Ala Arg
                 180                 185                 190

 cac ttc ttt aag aat ctt ggt gtt gtg gtt gcc cca cat aca tta aag      624
 His Phe Phe Lys Asn Leu Gly Val Val Val Ala Pro His Thr Leu Lys
             195                 200                 205

 tta cca gaa gag cct atc aca cgg tgg ggc gag tat tgg tgt gag gtg      672
 Leu Pro Glu Glu Pro Ile Thr Arg Trp Gly Glu Tyr Trp Cys Glu Val
         210                 215                 220

 acg gta aat ggg ctt gat act gtg aga gtg cct atg tct gtc gtg aac      720
 Thr Val Asn Gly Leu Asp Thr Val Arg Val Pro Met Ser Val Val Asn
     225                 230                 235

 ttt gag aag ccc aag acc aaa aga tat aag tac tgg tta gcc cag caa      768
 Phe Glu Lys Pro Lys Thr Lys Arg Tyr Lys Tyr Trp Leu Ala Gln Gln
 240                 245                 250                 255

 gct gcc aag gct atg gcc ccc acc agc ccc cag atc taa atctactctc       817
 Ala Ala Lys Ala Met Ala Pro Thr Ser Pro Gln Ile 
                 260                 265

 cctccaaggc agcaaagcag aatcgggagc agtggagcag aaatgtgcaa gcaccctgat    877

 ctcactccca gctctgacca aatacagaat tttagagaac atctgaagac atcagactgc    937

 actgcgtata catgttgaat tcttcatttt tgccatcttt aactgtcatc actggggcag    997

 ggaagtcctg ttccagaagt accaggctgt agatttgata agctagatgc agtagaccga   1057

 aaccatccaa aacctgttta gcttcttcct ccattggagt ttattgggac aaacaggaga   1117

 gccagccatt gtctccagta cttgcctcat tctcatcatc caaactgaac atttgtatcc   1177

 caagcagaaa taaagagaat atgttctttt taaaaaaaaa aaaa                    1221




      <210> 125
      <211> 2187
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (207)..(1913)

      <400> 125
 cccacgcgtc cgggcttccg gttggggtgg cagggtggtg gatctgtcgg tcccgttttc     60

 ccgtcgcacg tggtggccac tgttggcttc tgaatggttt gcaaggcgga tatccacgcc    120

 aaggcctttg gatcggccgt gggtacatcc gtctgagccg ttcctttcca tcgcagagcg    180

 gcggcctccg gcggcgctct ccagtc atg gac tac cgg cgg ctt ctc atg agc     233
                              Met Asp Tyr Arg Arg Leu Leu Met Ser
                                1               5

 cgg gtg gtc ccc ggg caa ttc gac gac gcg gac tcc tct gac agt gaa      281
 Arg Val Val Pro Gly Gln Phe Asp Asp Ala Asp Ser Ser Asp Ser Glu
  10                  15                  20                  25

 aac aga gac ttg aag aca gtc aaa gag aag gat gac att ctg ttt gaa      329
 Asn Arg Asp Leu Lys Thr Val Lys Glu Lys Asp Asp Ile Leu Phe Glu
                  30                  35                  40

 gac ctt caa gac aat gtg aat gag aat ggt gaa ggt gaa ata gaa gat      377
 Asp Leu Gln Asp Asn Val Asn Glu Asn Gly Glu Gly Glu Ile Glu Asp
              45                  50                  55

 gag gag gag gag ggt tat gat gat gat gat gat gac tgg gac tgg gat      425
 Glu Glu Glu Glu Gly Tyr Asp Asp Asp Asp Asp Asp Trp Asp Trp Asp
          60                  65                  70

 gaa gga gtt gga aaa ctc gcc aag ggt tat gtc tgg aat gga gga agc      473
 Glu Gly Val Gly Lys Leu Ala Lys Gly Tyr Val Trp Asn Gly Gly Ser
      75                  80                  85

 aac cca cag gca aat cga cag acc tcc gac agc agt tca gcc aaa atg      521
 Asn Pro Gln Ala Asn Arg Gln Thr Ser Asp Ser Ser Ser Ala Lys Met
  90                  95                 100                 105

 tct act cca gca gac aag gtc tta cgg aaa ttt gag aat aaa att aat      569
 Ser Thr Pro Ala Asp Lys Val Leu Arg Lys Phe Glu Asn Lys Ile Asn
                 110                 115                 120

 tta gat aag cta aat gtt act gat tcc gtc ata aat aaa gtc acc gaa      617
 Leu Asp Lys Leu Asn Val Thr Asp Ser Val Ile Asn Lys Val Thr Glu
             125                 130                 135

 aag tct aga caa aag gaa gca gat atg tat cgc atc aaa gat aag gca      665
 Lys Ser Arg Gln Lys Glu Ala Asp Met Tyr Arg Ile Lys Asp Lys Ala
         140                 145                 150

 gac aga gca act gta gaa cag gtg ttg gat ccc aga aca aga atg att      713
 Asp Arg Ala Thr Val Glu Gln Val Leu Asp Pro Arg Thr Arg Met Ile
     155                 160                 165

 tta ttc aag atg ttg act aga gga atc ata aca gag ata aat ggc tgc      761
 Leu Phe Lys Met Leu Thr Arg Gly Ile Ile Thr Glu Ile Asn Gly Cys
 170                 175                 180                 185

 att agc aca gga aaa gaa gct aat gta tac cat gct agc aca gca aat      809
 Ile Ser Thr Gly Lys Glu Ala Asn Val Tyr His Ala Ser Thr Ala Asn
                 190                 195                 200

 gga gag agc aga gca atc aaa att tat aaa act tct att ttg gtg ttc      857
 Gly Glu Ser Arg Ala Ile Lys Ile Tyr Lys Thr Ser Ile Leu Val Phe
             205                 210                 215

 aaa gat cgg gat aaa tat gta agt gga gaa ttc aga ttt cgt cat ggc      905
 Lys Asp Arg Asp Lys Tyr Val Ser Gly Glu Phe Arg Phe Arg His Gly
         220                 225                 230

 tat tgt aaa gga aac cct agg aaa atg gtg aaa act tgg gca gaa aaa      953
 Tyr Cys Lys Gly Asn Pro Arg Lys Met Val Lys Thr Trp Ala Glu Lys
     235                 240                 245

 gaa atg agg aac tta atc agg cta aac aca gca gag ata cca tgt cca     1001
 Glu Met Arg Asn Leu Ile Arg Leu Asn Thr Ala Glu Ile Pro Cys Pro
 250                 255                 260                 265

 gaa cca ata atg cta aga agt cat gtt ctt gtc atg agt ttc atc ggt     1049
 Glu Pro Ile Met Leu Arg Ser His Val Leu Val Met Ser Phe Ile Gly
                 270                 275                 280

 aaa gat gac atg cct gca cca ctc ttg aaa aat gtc cag tta tca gaa     1097
 Lys Asp Asp Met Pro Ala Pro Leu Leu Lys Asn Val Gln Leu Ser Glu
             285                 290                 295

 tcc aag gct cgg gag ttg tac ctg cag gtc att cag tac atg aga aga     1145
 Ser Lys Ala Arg Glu Leu Tyr Leu Gln Val Ile Gln Tyr Met Arg Arg
         300                 305                 310

 atg tat cag gat gcc aga ctt gtc cat gca gat ctc agt gaa ttt aac     1193
 Met Tyr Gln Asp Ala Arg Leu Val His Ala Asp Leu Ser Glu Phe Asn
     315                 320                 325

 atg ctg tac cac ggt gga ggc gtg tat atc att gac gtg tct cag tcc     1241
 Met Leu Tyr His Gly Gly Gly Val Tyr Ile Ile Asp Val Ser Gln Ser
 330                 335                 340                 345

 gtg gag cac gac cac cca cat gcc ttg gag ttc ttg aga aag gat tgc     1289
 Val Glu His Asp His Pro His Ala Leu Glu Phe Leu Arg Lys Asp Cys
                 350                 355                 360

 gcc aac gtc aat gat ttc ttt atg agg cac agt gtt gct gtc atg act     1337
 Ala Asn Val Asn Asp Phe Phe Met Arg His Ser Val Ala Val Met Thr
             365                 370                 375

 gtg cgg gag ctc ttt gaa ttt gtc aca gat cca tcc att aca cat gag     1385
 Val Arg Glu Leu Phe Glu Phe Val Thr Asp Pro Ser Ile Thr His Glu
         380                 385                 390

 aac atg gat gct tat ctc tca aag gcc atg gaa ata gca tct caa agg     1433
 Asn Met Asp Ala Tyr Leu Ser Lys Ala Met Glu Ile Ala Ser Gln Arg
     395                 400                 405

 acc aag gaa gaa cgg tct agc caa gat cat gtg gat gaa gag gtg ttt     1481
 Thr Lys Glu Glu Arg Ser Ser Gln Asp His Val Asp Glu Glu Val Phe
 410                 415                 420                 425

 aag cga gca tat att cct aga acc ttg aat gaa gtg aaa aat tat gag     1529
 Lys Arg Ala Tyr Ile Pro Arg Thr Leu Asn Glu Val Lys Asn Tyr Glu
                 430                 435                 440

 agg gat atg gac ata att atg aaa ttg aag gaa gag gac atg gcc atg     1577
 Arg Asp Met Asp Ile Ile Met Lys Leu Lys Glu Glu Asp Met Ala Met
             445                 450                 455

 aat gcc caa caa gat aat att cta tac cag act gtt aca gga ttg aag     1625
 Asn Ala Gln Gln Asp Asn Ile Leu Tyr Gln Thr Val Thr Gly Leu Lys
         460                 465                 470

 aaa gat ttg tca gga gtt cag aag gtc cct gca ctc cta gaa aat caa     1673
 Lys Asp Leu Ser Gly Val Gln Lys Val Pro Ala Leu Leu Glu Asn Gln
     475                 480                 485

 gtg gag gaa agg act tgt tct gat tca gaa gat att gga agc tct gag     1721
 Val Glu Glu Arg Thr Cys Ser Asp Ser Glu Asp Ile Gly Ser Ser Glu
 490                 495                 500                 505

 tgc tct gac aca gac tct gaa gag cag gga gac cat gcc cgc ccc aag     1769
 Cys Ser Asp Thr Asp Ser Glu Glu Gln Gly Asp His Ala Arg Pro Lys
                 510                 515                 520

 aaa cac acc acg gac cct gac att gat aaa aaa gaa aga aaa aag atg     1817
 Lys His Thr Thr Asp Pro Asp Ile Asp Lys Lys Glu Arg Lys Lys Met
             525                 530                 535

 gtc aag gaa gcc cag aga gag aaa aga aaa aac aaa att cct aaa cat     1865
 Val Lys Glu Ala Gln Arg Glu Lys Arg Lys Asn Lys Ile Pro Lys His
         540                 545                 550

 gtg aaa aaa aga aag gag aag aca gcc aag acg aaa aaa ggc aaa tag     1913
 Val Lys Lys Arg Lys Glu Lys Thr Ala Lys Thr Lys Lys Gly Lys 
     555                 560                 565

 aatgagaacc atattatgta cagtcatttt cctcagttcc ttttctcgcc tgaactctta   1973

 agctgcatct ggaagatggc ttattggttt taaccagatt gtcatcgtgg cactgtctgt   2033

 gaagacggat tcaaatgttt tcatgtaact atgtaaaaag ctctaagctc tagagtctag   2093

 atccagtcac tgactctgtc tggtgttgac agaggattta tttaagctat tattttaata   2153

 aagaactttg tacattttta aaaaaaaaaa aaaa                               2187




      <210> 126
      <211> 2261
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(2169)

      <400> 126
 aggaaggacg cgtgcagagg accgcagagg ggtggccgtg gctgagagga gacagcgccg     60

 cagcactgag ggtttgggct tgcaggcgct gcaggagacg cccaggcgga gtcttgtctc    120

 gcagccagct ctgagcggga ggcctgagcg ggaagcattg gcgtccgagc gacttctagg    180

 agcctggggt tcggcgct  atg gag gag ctc gat ggc gag cca aca gtc act     231
                      Met Glu Glu Leu Asp Gly Glu Pro Thr Val Thr
                        1               5                  10

 ttg att cca ggc gtg aat tcc aag aag aac caa atg tat ttt gac tgg      279
 Leu Ile Pro Gly Val Asn Ser Lys Lys Asn Gln Met Tyr Phe Asp Trp
              15                  20                  25

 ggt cca ggg gag atg ctg gta tgt gaa acc tcc ttc aac aaa aaa gaa      327
 Gly Pro Gly Glu Met Leu Val Cys Glu Thr Ser Phe Asn Lys Lys Glu
          30                  35                  40

 aaa tca gag atg gtg cca agt tgc ccc ttt atc tat atc atc cgt aag      375
 Lys Ser Glu Met Val Pro Ser Cys Pro Phe Ile Tyr Ile Ile Arg Lys
      45                  50                  55

 gat gta gat gtt tac tct caa atc ttg aga aaa ctc ttc aat gaa tcc      423
 Asp Val Asp Val Tyr Ser Gln Ile Leu Arg Lys Leu Phe Asn Glu Ser
  60                  65                  70                  75

 cat gga atc ttt ctg ggc ctc cag aga att gac gaa gag ttg act gga      471
 His Gly Ile Phe Leu Gly Leu Gln Arg Ile Asp Glu Glu Leu Thr Gly
                  80                  85                  90

 aaa tcc aga aaa tct caa ttg gtt cga gtg agt aaa aac tac cga tca      519
 Lys Ser Arg Lys Ser Gln Leu Val Arg Val Ser Lys Asn Tyr Arg Ser
              95                 100                 105

 gtc atc aga gca tgt atg gag gaa atg cac cag gtt gca att gct gct      567
 Val Ile Arg Ala Cys Met Glu Glu Met His Gln Val Ala Ile Ala Ala
         110                 115                 120

 aaa gat cca gcc aat ggc cgc cag ttc agc agc cag gtc tcc att ttg      615
 Lys Asp Pro Ala Asn Gly Arg Gln Phe Ser Ser Gln Val Ser Ile Leu
     125                 130                 135

 tca gca atg gag ctc atc tgg aac ctg tgt gag att ctt ttt att gaa      663
 Ser Ala Met Glu Leu Ile Trp Asn Leu Cys Glu Ile Leu Phe Ile Glu
 140                 145                 150                 155

 gtg gcc cca gct ggc cct ctc ctc ctc cat ctc ctt gac tgg gtc cgg      711
 Val Ala Pro Ala Gly Pro Leu Leu Leu His Leu Leu Asp Trp Val Arg
                 160                 165                 170

 ctc cat gtg tgc gag gtg gac agt ttg tcg gca gat gtt ctg ggc agt      759
 Leu His Val Cys Glu Val Asp Ser Leu Ser Ala Asp Val Leu Gly Ser
             175                 180                 185

 gag aat cca agc aaa cat gac agc ttc tgg aac ttg gtg acc atc ttg      807
 Glu Asn Pro Ser Lys His Asp Ser Phe Trp Asn Leu Val Thr Ile Leu
         190                 195                 200

 gtg ctg cag ggc cgg ctg gat gag gcc cga cag atg ctc tcc aag gaa      855
 Val Leu Gln Gly Arg Leu Asp Glu Ala Arg Gln Met Leu Ser Lys Glu
     205                 210                 215

 gcc gat gcc agc ccc gcc tct gca ggc ata tgc cga atc atg ggg gac      903
 Ala Asp Ala Ser Pro Ala Ser Ala Gly Ile Cys Arg Ile Met Gly Asp
 220                 225                 230                 235

 ctg atg agg aca atg ccc att ctt agt cct ggg aac acc cag aca ctg      951
 Leu Met Arg Thr Met Pro Ile Leu Ser Pro Gly Asn Thr Gln Thr Leu
                 240                 245                 250

 aca gag ctg gag ctg aag tgg cag cac tgg cac gag gaa tgt gag cgg      999
 Thr Glu Leu Glu Leu Lys Trp Gln His Trp His Glu Glu Cys Glu Arg
             255                 260                 265

 tac ctc cag gac agc aca ttc gcc acc agc cct cac ctg gag tct ctc     1047
 Tyr Leu Gln Asp Ser Thr Phe Ala Thr Ser Pro His Leu Glu Ser Leu
         270                 275                 280

 ttg aag att atg ctg gga gac gaa gct gcc ttg tta gag cag aag gaa     1095
 Leu Lys Ile Met Leu Gly Asp Glu Ala Ala Leu Leu Glu Gln Lys Glu
     285                 290                 295

 ctt ctg agt aat tgg tat cat ttc cta gtg act cgg ctc ttg tac tcc     1143
 Leu Leu Ser Asn Trp Tyr His Phe Leu Val Thr Arg Leu Leu Tyr Ser
 300                 305                 310                 315

 aat ccc aca gta aaa ccc att gat ctg cac tac tat gcc cag tcc agc     1191
 Asn Pro Thr Val Lys Pro Ile Asp Leu His Tyr Tyr Ala Gln Ser Ser
                 320                 325                 330

 ctg gac ctg ttt ctg gga ggt gag agc agc cca gaa ccc ctg gac aac     1239
 Leu Asp Leu Phe Leu Gly Gly Glu Ser Ser Pro Glu Pro Leu Asp Asn
             335                 340                 345

 atc ttg ttg gca gcc ttt gag ttt gac atc cat caa gta atc aaa gag     1287
 Ile Leu Leu Ala Ala Phe Glu Phe Asp Ile His Gln Val Ile Lys Glu
         350                 355                 360

 tgc agc atc gcc ctg agc aac tgg tgg ttt gtg gcc cac ctg aca gac     1335
 Cys Ser Ile Ala Leu Ser Asn Trp Trp Phe Val Ala His Leu Thr Asp
     365                 370                 375

 ctg ctg gac cac tgc aag ctc ctc cag tca cac aac ctc tat ttc ggt     1383
 Leu Leu Asp His Cys Lys Leu Leu Gln Ser His Asn Leu Tyr Phe Gly
 380                 385                 390                 395

 tcc aac atg aga gag ttc ctc ctg ctg gag tac gcc tcg gga ctg ttt     1431
 Ser Asn Met Arg Glu Phe Leu Leu Leu Glu Tyr Ala Ser Gly Leu Phe
                 400                 405                 410

 gct cat ccc agc ctg tgg cag ctg ggg gtc gat tac ttt gat tac tgc     1479
 Ala His Pro Ser Leu Trp Gln Leu Gly Val Asp Tyr Phe Asp Tyr Cys
             415                 420                 425

 ccc gag ctg ggc cga gtc tcc ctg gag ctg cac att gag cgg ata cct     1527
 Pro Glu Leu Gly Arg Val Ser Leu Glu Leu His Ile Glu Arg Ile Pro
         430                 435                 440

 ctg aac acc gag cag aaa gcc ctg aag gtg ctg cgg atc tgt gag cag     1575
 Leu Asn Thr Glu Gln Lys Ala Leu Lys Val Leu Arg Ile Cys Glu Gln
     445                 450                 455

 cgg cag atg act gaa caa gtt cgc agc att tgt aag atc tta gcc atg     1623
 Arg Gln Met Thr Glu Gln Val Arg Ser Ile Cys Lys Ile Leu Ala Met
 460                 465                 470                 475

 aaa gcc gtc cgc aac aat cgc ctg ggt tct gcc ctc tct tgg agc atc     1671
 Lys Ala Val Arg Asn Asn Arg Leu Gly Ser Ala Leu Ser Trp Ser Ile
                 480                 485                 490

 cgt gct aag gat gcc gcc ttt gcc acg ctc gtg tca gac agg ttc ctc     1719
 Arg Ala Lys Asp Ala Ala Phe Ala Thr Leu Val Ser Asp Arg Phe Leu
             495                 500                 505

 agg gat tac tgt gag cga ggc tgc ttt tct gat ttg gat ctc att gac     1767
 Arg Asp Tyr Cys Glu Arg Gly Cys Phe Ser Asp Leu Asp Leu Ile Asp
         510                 515                 520

 aac ctg ggg cca gcc atg atg ctc agt gac cga ctg aca ttc ctg gga     1815
 Asn Leu Gly Pro Ala Met Met Leu Ser Asp Arg Leu Thr Phe Leu Gly
     525                 530                 535

 aag tat cgc gag ttc cac cgt atg tac ggg gag aag cgt ttt gcc gac     1863
 Lys Tyr Arg Glu Phe His Arg Met Tyr Gly Glu Lys Arg Phe Ala Asp
 540                 545                 550                 555

 gca gct tct ctc ctt ctg tcc ttg atg acg tct cgg att gcc cct cgg     1911
 Ala Ala Ser Leu Leu Leu Ser Leu Met Thr Ser Arg Ile Ala Pro Arg
                 560                 565                 570

 tct ttc tgg atg act ctg ctg aca gat gcc ttg ccc ctt ttg gaa cag     1959
 Ser Phe Trp Met Thr Leu Leu Thr Asp Ala Leu Pro Leu Leu Glu Gln
             575                 580                 585

 aaa cag gtg att ttc tca gca gaa cag act tat gag ttg atg cgg tgt     2007
 Lys Gln Val Ile Phe Ser Ala Glu Gln Thr Tyr Glu Leu Met Arg Cys
         590                 595                 600

 ctg gag gac ttg acg tca aga aga cct gtg cat gga gaa tct gat acc     2055
 Leu Glu Asp Leu Thr Ser Arg Arg Pro Val His Gly Glu Ser Asp Thr
     605                 610                 615

 gag cag ctc cag gat gat gac ata gag acc acc aag gtg gaa atg ctg     2103
 Glu Gln Leu Gln Asp Asp Asp Ile Glu Thr Thr Lys Val Glu Met Leu
 620                 625                 630                 635

 aga ctt tct ctg gca cga aat ctt gct cgg gca att ata aga gaa ggc     2151
 Arg Leu Ser Leu Ala Arg Asn Leu Ala Arg Ala Ile Ile Arg Glu Gly
                 640                 645                 650

 tca ctg gaa ggt tcc tga gaactg cttcaatgtg gtatctttgt atggcaatgt     2205
 Ser Leu Glu Gly Ser 
             655

 atatagattt tttaaaagaa taaatgttgt tttgcaaatg taaaaaaaaa aaaaaa       2261




      <210> 127
      <211> 4758
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(4381)

      <400> 127
 ctagctcaga aaccgctgca gatgacatcg caagctcggc acgaggtctc tgcggggcaa     60

 gatggcggcg cccagacagg cctggagcac ggatgaataa gagggaaccc ccacacggag    120

 acactgctgg agagagtcgt actggggagg cagctggagc agcaag   atg ctg tcg     175
                                                      Met Leu Ser
                                                        1

 aga ccg aag cca ggg gag tcc gag gtg gac ctg ctg cac ttc cag agt      223
 Arg Pro Lys Pro Gly Glu Ser Glu Val Asp Leu Leu His Phe Gln Ser
       5                  10                  15

 cag ttt ctc gca gct ggt gca gcc cca gca gtg cag ttg gtg aag aaa      271
 Gln Phe Leu Ala Ala Gly Ala Ala Pro Ala Val Gln Leu Val Lys Lys
  20                  25                  30                  35

 gga aat agg ggc ggt ggt gat gcc aac tca gac cgg cct ccg ctc cag      319
 Gly Asn Arg Gly Gly Gly Asp Ala Asn Ser Asp Arg Pro Pro Leu Gln
                  40                  45                  50

 gac cat cgg gat gtg gtg atg ttg gac aat ctc cca gat ttg ccc cca      367
 Asp His Arg Asp Val Val Met Leu Asp Asn Leu Pro Asp Leu Pro Pro
              55                  60                  65

 gct ttg gtc cct tct cct cca aag aga gcc agg ccc agc cct ggc cac      415
 Ala Leu Val Pro Ser Pro Pro Lys Arg Ala Arg Pro Ser Pro Gly His
          70                  75                  80

 tgc ctg cct gag gat gag gac cca gaa gag agg ctg agg agg cat gat      463
 Cys Leu Pro Glu Asp Glu Asp Pro Glu Glu Arg Leu Arg Arg His Asp
      85                  90                  95

 cag cac atc act gct gtc ttg act aag att att gaa cga gat aca agt      511
 Gln His Ile Thr Ala Val Leu Thr Lys Ile Ile Glu Arg Asp Thr Ser
 100                 105                 110                 115

 tca gtg gcc gtg aat ctg cct gtg ccc agt ggt gtt gct ttc cct gct      559
 Ser Val Ala Val Asn Leu Pro Val Pro Ser Gly Val Ala Phe Pro Ala
                 120                 125                 130

 gtg ttc ctt cgc tcg cgg gac aca cag ggg aaa tca gca aca tct ggt      607
 Val Phe Leu Arg Ser Arg Asp Thr Gln Gly Lys Ser Ala Thr Ser Gly
             135                 140                 145

 aag aga agc atc ttt gcc cag gaa att gcg gca agg agg ata gct gaa      655
 Lys Arg Ser Ile Phe Ala Gln Glu Ile Ala Ala Arg Arg Ile Ala Glu
         150                 155                 160

 gcc aag ggc cca tca gtt ggg gaa gtt gtg ccc aac gtg ggc cca cca      703
 Ala Lys Gly Pro Ser Val Gly Glu Val Val Pro Asn Val Gly Pro Pro
     165                 170                 175

 gag ggt gcc gtg acc tgt gag aca ccc act cct agg aac cag ggc tgc      751
 Glu Gly Ala Val Thr Cys Glu Thr Pro Thr Pro Arg Asn Gln Gly Cys
 180                 185                 190                 195

 cag ctt cct ggg agc agc cac agc ttt cag gga ccc aat ctg gtc aca      799
 Gln Leu Pro Gly Ser Ser His Ser Phe Gln Gly Pro Asn Leu Val Thr
                 200                 205                 210

 ggg aag ggg ctc agg gat caa gaa gct gag cag gaa gcc cag act atc      847
 Gly Lys Gly Leu Arg Asp Gln Glu Ala Glu Gln Glu Ala Gln Thr Ile
             215                 220                 225

 cat gaa gag aac ata gca aga ctg cag gcc atg gct cct gag gag atc      895
 His Glu Glu Asn Ile Ala Arg Leu Gln Ala Met Ala Pro Glu Glu Ile
         230                 235                 240

 ctg cag gaa cag cag cgg ttg ctg gcc cag ctt gac ccc agc ttg gtt      943
 Leu Gln Glu Gln Gln Arg Leu Leu Ala Gln Leu Asp Pro Ser Leu Val
     245                 250                 255

 gct ttc ttg aga tct cac agc cac acg caa gag caa aca gga gag aca      991
 Ala Phe Leu Arg Ser His Ser His Thr Gln Glu Gln Thr Gly Glu Thr
 260                 265                 270                 275

 gcc tct gag gag cag agg cca gga gga ccc tct gct aat gtc acc aag     1039
 Ala Ser Glu Glu Gln Arg Pro Gly Gly Pro Ser Ala Asn Val Thr Lys
                 280                 285                 290

 gag gaa ccc ctc atg tca gct ttt gcc agt gag ccc agg aag aga gac     1087
 Glu Glu Pro Leu Met Ser Ala Phe Ala Ser Glu Pro Arg Lys Arg Asp
             295                 300                 305

 aag ctg gag cca gaa gcc cca gct ctg gca ttg ccc gtg acc cct cag     1135
 Lys Leu Glu Pro Glu Ala Pro Ala Leu Ala Leu Pro Val Thr Pro Gln
         310                 315                 320

 aaa gaa tgg ctg cac atg gac act gtc gag ctg gag aag ctc cac tgg     1183
 Lys Glu Trp Leu His Met Asp Thr Val Glu Leu Glu Lys Leu His Trp
     325                 330                 335

 acc cag gac ttg ccc cct gtc cgg cgg cag cag aca cag gag gtg agg     1231
 Thr Gln Asp Leu Pro Pro Val Arg Arg Gln Gln Thr Gln Glu Val Arg
 340                 345                 350                 355

 agg gcc acc tgg cct aca agg ggt gga gga tgc agg ctc ggt tca gtc     1279
 Arg Ala Thr Trp Pro Thr Arg Gly Gly Gly Cys Arg Leu Gly Ser Val
                 360                 365                 370

 ttc agg gag ata cta ctg gcc cct gac gtg gac ctg ccc acc cac ctg     1327
 Phe Arg Glu Ile Leu Leu Ala Pro Asp Val Asp Leu Pro Thr His Leu
             375                 380                 385

 ggt ctg cac cac cat gga gag gag gca gag aga gcg ggg tat tcc cta     1375
 Gly Leu His His His Gly Glu Glu Ala Glu Arg Ala Gly Tyr Ser Leu
         390                 395                 400

 cag gag ctg ttc cac ctg acc cgc agc cag gtt tcc cag cag aga gca     1423
 Gln Glu Leu Phe His Leu Thr Arg Ser Gln Val Ser Gln Gln Arg Ala
     405                 410                 415

 ctg gca ctg cat gtg tta gcc cag gtc atc agc agg gcc cag gct ggt     1471
 Leu Ala Leu His Val Leu Ala Gln Val Ile Ser Arg Ala Gln Ala Gly
 420                 425                 430                 435

 gag ttt ggg gac cgg cta gca ggc agt gtc tta agc ctc ctt ttg gat     1519
 Glu Phe Gly Asp Arg Leu Ala Gly Ser Val Leu Ser Leu Leu Leu Asp
                 440                 445                 450

 gct ggt ttc ctc ttc cta ctg cgc ttc tcc ttg gat gac aga gtg gat     1567
 Ala Gly Phe Leu Phe Leu Leu Arg Phe Ser Leu Asp Asp Arg Val Asp
             455                 460                 465

 ggg gtc att gca acc gcc atc cgt gct ctt cgg gct ctg ctg gtg gct     1615
 Gly Val Ile Ala Thr Ala Ile Arg Ala Leu Arg Ala Leu Leu Val Ala
         470                 475                 480

 cct gga gat gag gag ctc ctc gac agc acc ttc tct tgg tac cat gga     1663
 Pro Gly Asp Glu Glu Leu Leu Asp Ser Thr Phe Ser Trp Tyr His Gly
     485                 490                 495

 gct ttg acg ttc cct ctg atg ccc agc cag gag gac aag gag gat gag     1711
 Ala Leu Thr Phe Pro Leu Met Pro Ser Gln Glu Asp Lys Glu Asp Glu
 500                 505                 510                 515

 gac aag gat gaa gaa tgc cca gca gga aaa gca aaa agg aaa agc cct     1759
 Asp Lys Asp Glu Glu Cys Pro Ala Gly Lys Ala Lys Arg Lys Ser Pro
                 520                 525                 530

 gaa gaa gaa agc cgg cct cca cct gac ctg gcc cga cat gat gtc atc     1807
 Glu Glu Glu Ser Arg Pro Pro Pro Asp Leu Ala Arg His Asp Val Ile
             535                 540                 545

 aag ggg ctc ctg gct acc agc ctg ctg cct cgg ctg cgc tac gtg ctg     1855
 Lys Gly Leu Leu Ala Thr Ser Leu Leu Pro Arg Leu Arg Tyr Val Leu
         550                 555                 560

 gag gtg aca tac cca gga cct gcg gtg gtc ctt gac atc ctg gct gtg     1903
 Glu Val Thr Tyr Pro Gly Pro Ala Val Val Leu Asp Ile Leu Ala Val
     565                 570                 575

 ctc atc cgc ctg gcc cgg cat tcc ctg gaa tca gcc aca agg gtc ctg     1951
 Leu Ile Arg Leu Ala Arg His Ser Leu Glu Ser Ala Thr Arg Val Leu
 580                 585                 590                 595

 gag tgc cct cgg ctg ata gag act ata gtt cga gag ttc ttg ccc acc     1999
 Glu Cys Pro Arg Leu Ile Glu Thr Ile Val Arg Glu Phe Leu Pro Thr
                 600                 605                 610

 agt tgg tct cct gtg ggg gca ggg cct acc cct agt cta tac aaa gta     2047
 Ser Trp Ser Pro Val Gly Ala Gly Pro Thr Pro Ser Leu Tyr Lys Val
             615                 620                 625

 ccc tgt gct act gcc atg aaa cta ctt cgt gtc ctg gcc tca gct ggg     2095
 Pro Cys Ala Thr Ala Met Lys Leu Leu Arg Val Leu Ala Ser Ala Gly
         630                 635                 640

 agg aat att gct gcc cgg ctg ttg agc agc ttt gat ctc cgg agc cgc     2143
 Arg Asn Ile Ala Ala Arg Leu Leu Ser Ser Phe Asp Leu Arg Ser Arg
     645                 650                 655

 ctg tgc cgc atc ata gct gag gct ccc caa gaa ctg gcc ttg ccc cca     2191
 Leu Cys Arg Ile Ile Ala Glu Ala Pro Gln Glu Leu Ala Leu Pro Pro
 660                 665                 670                 675

 gag gaa gct gag atg ctg agc acc gag gcc ctc cgt ctg tgg gct gtg     2239
 Glu Glu Ala Glu Met Leu Ser Thr Glu Ala Leu Arg Leu Trp Ala Val
                 680                 685                 690

 gct gcc tcc tat ggc cag ggc ggt tac ctt tac agg gag ctc tac cca     2287
 Ala Ala Ser Tyr Gly Gln Gly Gly Tyr Leu Tyr Arg Glu Leu Tyr Pro
             695                 700                 705

 gtg ctg atg cgg gcc ttg cag gtg gtg ccg cgg gag ctc agc acc cac     2335
 Val Leu Met Arg Ala Leu Gln Val Val Pro Arg Glu Leu Ser Thr His
         710                 715                 720

 cca cct caa ccc ctg tcc atg cag cgg ata gcc tca ctg ctc act ctc     2383
 Pro Pro Gln Pro Leu Ser Met Gln Arg Ile Ala Ser Leu Leu Thr Leu
     725                 730                 735

 ctc acc cag cta acc ctg gca gcc ggc agt acc cct gct gaa acc atc     2431
 Leu Thr Gln Leu Thr Leu Ala Ala Gly Ser Thr Pro Ala Glu Thr Ile
 740                 745                 750                 755

 agt gat tct gct gag gcc agc ctc tcg gcc acc cct tcc tta gtc act     2479
 Ser Asp Ser Ala Glu Ala Ser Leu Ser Ala Thr Pro Ser Leu Val Thr
                 760                 765                 770

 tgg aca cag gtg tct ggg ctc cag cct ctt gtt gag ccg tgt cta agg     2527
 Trp Thr Gln Val Ser Gly Leu Gln Pro Leu Val Glu Pro Cys Leu Arg
             775                 780                 785

 cag acc ttg aag ttg ctg tcc aga cct gag atg tgg aga gcc gtg ggc     2575
 Gln Thr Leu Lys Leu Leu Ser Arg Pro Glu Met Trp Arg Ala Val Gly
         790                 795                 800

 cca gtg ccc gtt gcc tgc ctg ttg ttc ctg gga gcc tac tac cag gcc     2623
 Pro Val Pro Val Ala Cys Leu Leu Phe Leu Gly Ala Tyr Tyr Gln Ala
     805                 810                 815

 tgg agc cag caa cca agc tca tgc ccg gag gat tgg ctc cag gac atg     2671
 Trp Ser Gln Gln Pro Ser Ser Cys Pro Glu Asp Trp Leu Gln Asp Met
 820                 825                 830                 835

 gag cgc ctg tca gag gag ctg ctg ctg cca ctg ctg agt cag ccc aca     2719
 Glu Arg Leu Ser Glu Glu Leu Leu Leu Pro Leu Leu Ser Gln Pro Thr
                 840                 845                 850

 ctg ggc agc ctg tgg gat tcc ctt agg cac tgc tcc ctt ctc tgc aac     2767
 Leu Gly Ser Leu Trp Asp Ser Leu Arg His Cys Ser Leu Leu Cys Asn
             855                 860                 865

 ccg ctg tcc tgt gtg cca gcc ctt gaa gct ccc ccc agc ctc gtg tca     2815
 Pro Leu Ser Cys Val Pro Ala Leu Glu Ala Pro Pro Ser Leu Val Ser
         870                 875                 880

 ctg ggc tgc tcg gga ggc tgc ccc cgt ctc agt ctg gct ggc tca gcc     2863
 Leu Gly Cys Ser Gly Gly Cys Pro Arg Leu Ser Leu Ala Gly Ser Ala
     885                 890                 895

 tca ccc ttc cca ttc ctc act gcc ctc ctc tct ctt ctt aat acc ctg     2911
 Ser Pro Phe Pro Phe Leu Thr Ala Leu Leu Ser Leu Leu Asn Thr Leu
 900                 905                 910                 915

 gcc cag atc cac aag ggg ctg tgt ggc cag ctg gct gcc ata ttg gct     2959
 Ala Gln Ile His Lys Gly Leu Cys Gly Gln Leu Ala Ala Ile Leu Ala
                 920                 925                 930

 gcc ccg gga ctc cag aat tac ttc ctc cag tgt gtg gct cct ggg gct     3007
 Ala Pro Gly Leu Gln Asn Tyr Phe Leu Gln Cys Val Ala Pro Gly Ala
             935                 940                 945

 gcc cca cac ctc aca cct ttc tct gca tgg gcc ctg cgc cat gag tac     3055
 Ala Pro His Leu Thr Pro Phe Ser Ala Trp Ala Leu Arg His Glu Tyr
         950                 955                 960

 cac ctg cag tac ctg gca ctc gct ctg gcc cag aaa gcg gca gcg ctg     3103
 His Leu Gln Tyr Leu Ala Leu Ala Leu Ala Gln Lys Ala Ala Ala Leu
     965                 970                 975

 cag cca ctg cca gcc acc cat gct gcc ctc tat cat ggt atg gcc ttg     3151
 Gln Pro Leu Pro Ala Thr His Ala Ala Leu Tyr His Gly Met Ala Leu
 980                 985                 990                 995

 gcc ctg ctg agc cgg ctg ctg ccc gga agt gag tac ctc acc cat gag     3199
 Ala Leu Leu Ser Arg Leu Leu Pro Gly Ser Glu Tyr Leu Thr His Glu
                1000                1005                1010

 ctg ctg ctg agc tgt gta ttc cgg ctg gag ttc ctc ccg gaa aga aca     3247
 Leu Leu Leu Ser Cys Val Phe Arg Leu Glu Phe Leu Pro Glu Arg Thr
            1015                1020                1025

 tca ggg ggt cca gag gca gcc gac ttc tct gac cag ctg tcg tta gga     3295
 Ser Gly Gly Pro Glu Ala Ala Asp Phe Ser Asp Gln Leu Ser Leu Gly
        1030                1035                1040

 agc agc agg gtc cct cgg tgt ggg caa ggg act ctg ctg gct cag gcc     3343
 Ser Ser Arg Val Pro Arg Cys Gly Gln Gly Thr Leu Leu Ala Gln Ala
    1045                1050                1055

 tgc cag gac ctc ccc agc atc cgc aac tgc tac ctg act cat tgc tcg     3391
 Cys Gln Asp Leu Pro Ser Ile Arg Asn Cys Tyr Leu Thr His Cys Ser
1060                1065                1070                1075

 cca gcc cga gcc agt ctg ctg gcc tcc cag gct ctg cac cga ggg gag     3439
 Pro Ala Arg Ala Ser Leu Leu Ala Ser Gln Ala Leu His Arg Gly Glu
                1080                1085                1090

 cta cag cga gtc cca acc ctg cta ctg ccc atg cct acg gag ccg ctg     3487
 Leu Gln Arg Val Pro Thr Leu Leu Leu Pro Met Pro Thr Glu Pro Leu
            1095                1100                1105

 ctg ccc acc gac tgg ccc ttc ctg cca ctg att cgc ctc tac cac cgg     3535
 Leu Pro Thr Asp Trp Pro Phe Leu Pro Leu Ile Arg Leu Tyr His Arg
        1110                1115                1120

 gct tca gac acc ccc tcg gga ctc tct ccc aca gac acc atg ggc aca     3583
 Ala Ser Asp Thr Pro Ser Gly Leu Ser Pro Thr Asp Thr Met Gly Thr
    1125                1130                1135

 gcc atg cgg gtc ctg cag tgg gtg cta gtt ttg gag agc tgg cgc ccc     3631
 Ala Met Arg Val Leu Gln Trp Val Leu Val Leu Glu Ser Trp Arg Pro
1140                1145                1150                1155

 cag gct ctc tgg gct gtg ccc cct gct gcc cgc ctg gca cgg ctc atg     3679
 Gln Ala Leu Trp Ala Val Pro Pro Ala Ala Arg Leu Ala Arg Leu Met
                1160                1165                1170

 tgt gtg ttc ctg gtg gac agt gag ctg ttc cgg gag tcc cca gta cag     3727
 Cys Val Phe Leu Val Asp Ser Glu Leu Phe Arg Glu Ser Pro Val Gln
            1175                1180                1185

 cat ctg gtg gca gcc ctc ctc gcc cag ctc tgt cag cct caa gtc ttg     3775
 His Leu Val Ala Ala Leu Leu Ala Gln Leu Cys Gln Pro Gln Val Leu
        1190                1195                1200

 cca aac ctc aac ctg gac tgc cga ctc cct ggc ctg acg tct ttc cct     3823
 Pro Asn Leu Asn Leu Asp Cys Arg Leu Pro Gly Leu Thr Ser Phe Pro
    1205                1210                1215

 gac ctc tat gcc aac ttc ctg gat cat ttt gag gct gtc tct ttt ggg     3871
 Asp Leu Tyr Ala Asn Phe Leu Asp His Phe Glu Ala Val Ser Phe Gly
1220                1225                1230                1235

 gac cac ctc ttt ggg gcc ctg gtc ctc ctg ccc ctg cag cgt cgg ttc     3919
 Asp His Leu Phe Gly Ala Leu Val Leu Leu Pro Leu Gln Arg Arg Phe
                1240                1245                1250

 agt gtc acc ttg cgc ctt gcc ctc ttt ggg gaa cac gtg gga gcc ttg     3967
 Ser Val Thr Leu Arg Leu Ala Leu Phe Gly Glu His Val Gly Ala Leu
            1255                1260                1265

 cga gct ctg agc ctg cct ctg acc cag ttg cct gtg tcc ctg gag tgt     4015
 Arg Ala Leu Ser Leu Pro Leu Thr Gln Leu Pro Val Ser Leu Glu Cys
        1270                1275                1280

 tac aca gtg cct cct gaa gac aac ctg gcc ctc ctt cag ctc tac ttc     4063
 Tyr Thr Val Pro Pro Glu Asp Asn Leu Ala Leu Leu Gln Leu Tyr Phe
    1285                1290                1295

 cgg acc ctg gtt act ggt gcg ctc cgc cca cgt tgg tgc ccc gtg ctc     4111
 Arg Thr Leu Val Thr Gly Ala Leu Arg Pro Arg Trp Cys Pro Val Leu
1300                1305                1310                1315

 tat gct gtg gct gtg gct cat gtc aat agc ttc atc ttc tct cag gac     4159
 Tyr Ala Val Ala Val Ala His Val Asn Ser Phe Ile Phe Ser Gln Asp
                1320                1325                1330

 cca cag agc tca gat gag gtc aaa gct gcc cgc agg agt atg ctg cag     4207
 Pro Gln Ser Ser Asp Glu Val Lys Ala Ala Arg Arg Ser Met Leu Gln
            1335                1340                1345

 aaa aca tgg ctg ctg gca gat gag ggt ctc cgg cag cac ctc ctg cac     4255
 Lys Thr Trp Leu Leu Ala Asp Glu Gly Leu Arg Gln His Leu Leu His
        1350                1355                1360

 tat aag ctt ccc aat tcc acg ctc cca gag ggc ttt gag ctc tat tct     4303
 Tyr Lys Leu Pro Asn Ser Thr Leu Pro Glu Gly Phe Glu Leu Tyr Ser
    1365                1370                1375

 cag ttg ccc cct ctg cgt cag cac tac ctc cag aga ctg act tca aca     4351
 Gln Leu Pro Pro Leu Arg Gln His Tyr Leu Gln Arg Leu Thr Ser Thr
1380                1385                1390                1395

 gtg ctc caa aat ggg gta tca gag acc tag g atagttgata tagatggaaa     4402
 Val Leu Gln Asn Gly Val Ser Glu Thr 
                1400

 gatgggtacg ttgtcctgta tccagccttt caacagatgt ctggccagac gaagaacatt   4462

 gtgtcctaat ggtaggcagg agaccaagga gcagaaggct tgccttcctg ggagcaggtt   4522

 gtttgagctg ttttagagca gtgagcccta ccattacatc ctgatatctg gggcttctga   4582

 aggtctgtgc tgggagtgaa gagtggctta gctatttacc cgctctttgg ggacagggca   4642

 aactaaatgc atcccttctt acctaactcc caacccctgc cctgggctga ggcatatgaa   4702

 tgctatagtt gtgcattaaa ataaatgttt tttatctcct ggaaaaaaaa aaaaaa       4758




      <210> 128
      <211> 3718
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (331)..(1437)

      <400> 128
 aaaaggagac ctagccttat tggtgagtcc ttcaactgtt atcctccaaa ctgagggtga     60

 cctggagttg agctatattt tccctggaaa ataggttggg gtcagagtca acatcagagc    120

 agagatatgc ccattttggc agatgtcata taggtttagg tttgccagag aaaatacagg    180

 atgcctactt atgtcccaaa tactgcatgg cccatactta ttctaaaaaa gtatttgctt    240

 tatttaaatc tggaatttac atttaactag gtgtcctgta ttttagtttc gaaatctggc    300

 atccaggccc tttgtaggag cattcaacca     atg gcg ttg tct cca caa aca     351
                                      Met Ala Leu Ser Pro Gln Thr
                                        1               5

 ttt aag cct ctt act aga agg aac att aac aag ggt cga ttt cag gag      399
 Phe Lys Pro Leu Thr Arg Arg Asn Ile Asn Lys Gly Arg Phe Gln Glu
          10                  15                  20

 gac aca gtt aca atg gga agc cca aag agt ggg tct caa ggc tgg ctg      447
 Asp Thr Val Thr Met Gly Ser Pro Lys Ser Gly Ser Gln Gly Trp Leu
      25                  30                  35

 agt agc tgg ctg ccc acg tgg cgc ccc act tcc atg tct cag ctg aag      495
 Ser Ser Trp Leu Pro Thr Trp Arg Pro Thr Ser Met Ser Gln Leu Lys
  40                  45                  50                  55

 aat gtg gaa gcc agg atc ctc cag tgt ctc cag aat aag ttc ctg gcc      543
 Asn Val Glu Ala Arg Ile Leu Gln Cys Leu Gln Asn Lys Phe Leu Ala
                  60                  65                  70

 aga tat gta tcc ctc cca aac cag aat aag atc tgg acg gtg act gtg      591
 Arg Tyr Val Ser Leu Pro Asn Gln Asn Lys Ile Trp Thr Val Thr Val
              75                  80                  85

 agc ccc gag caa aac gac cgc acc ccc ttg gtg atg gtg cat ggt ttt      639
 Ser Pro Glu Gln Asn Asp Arg Thr Pro Leu Val Met Val His Gly Phe
          90                  95                 100

 ggg ggc ggc gtg ggt ctc tgg atc ctc aac atg gac tca ctg agt gcc      687
 Gly Gly Gly Val Gly Leu Trp Ile Leu Asn Met Asp Ser Leu Ser Ala
     105                 110                 115

 cgc cgc aca ctg cac acc ttc gat ctg ctt ggc ttc ggg cga agc tca      735
 Arg Arg Thr Leu His Thr Phe Asp Leu Leu Gly Phe Gly Arg Ser Ser
 120                 125                 130                 135

 agg cca gca ttc cca agg gac ccg gag ggg gct gag gat gag ttt gtg      783
 Arg Pro Ala Phe Pro Arg Asp Pro Glu Gly Ala Glu Asp Glu Phe Val
                 140                 145                 150

 aca tcg ata gag aca tgg cgg gag acc atg ggg atc ccc agc atg atc      831
 Thr Ser Ile Glu Thr Trp Arg Glu Thr Met Gly Ile Pro Ser Met Ile
             155                 160                 165

 ctc ctg ggg cac agt ttg gga gga ttc ctg gcc act tct tac tca atc      879
 Leu Leu Gly His Ser Leu Gly Gly Phe Leu Ala Thr Ser Tyr Ser Ile
         170                 175                 180

 aag tac cct gat aga gtt aaa cac ctc atc ctg gtg gac cca tgg ggc      927
 Lys Tyr Pro Asp Arg Val Lys His Leu Ile Leu Val Asp Pro Trp Gly
     185                 190                 195

 ttt ccc ctc cga cca act aac ccc agt gag atc cgt gca ccc cca gcc      975
 Phe Pro Leu Arg Pro Thr Asn Pro Ser Glu Ile Arg Ala Pro Pro Ala
 200                 205                 210                 215

 tgg gtc aaa gcc gtg gca tct gtc cta gga cgt tcc aat cca ttg gct     1023
 Trp Val Lys Ala Val Ala Ser Val Leu Gly Arg Ser Asn Pro Leu Ala
                 220                 225                 230

 gtt ctt cga gta gct ggg ccc tgg ggg cct ggt ctg gtg cag cga ttc     1071
 Val Leu Arg Val Ala Gly Pro Trp Gly Pro Gly Leu Val Gln Arg Phe
             235                 240                 245

 cgg ccg gac ttc aaa cgc aag ttt gca gac ttc ttt gaa gat gat acc     1119
 Arg Pro Asp Phe Lys Arg Lys Phe Ala Asp Phe Phe Glu Asp Asp Thr
         250                 255                 260

 ata tca gag tat att tac cac tgc aac gca cag aat ccc agt ggt gag     1167
 Ile Ser Glu Tyr Ile Tyr His Cys Asn Ala Gln Asn Pro Ser Gly Glu
     265                 270                 275

 aca gca ttc aaa gcc atg atg gag tcc ttt ggc tgg gcc cgg cgc cct     1215
 Thr Ala Phe Lys Ala Met Met Glu Ser Phe Gly Trp Ala Arg Arg Pro
 280                 285                 290                 295

 atg ctg gag cga att cac ttg att cga aaa gat gtg cct atc act atg     1263
 Met Leu Glu Arg Ile His Leu Ile Arg Lys Asp Val Pro Ile Thr Met
                 300                 305                 310

 atc tac ggg tcc gac acc tgg ata gat acc agt acg gga aaa aag gtg     1311
 Ile Tyr Gly Ser Asp Thr Trp Ile Asp Thr Ser Thr Gly Lys Lys Val
             315                 320                 325

 aag atg cag cgg ccg gat tcc tat gtc cga gac atg gag att aag ggt     1359
 Lys Met Gln Arg Pro Asp Ser Tyr Val Arg Asp Met Glu Ile Lys Gly
         330                 335                 340

 gcc tcc cac cat gtc tat gct gac cag cca cac atc ttc aat gct gtg     1407
 Ala Ser His His Val Tyr Ala Asp Gln Pro His Ile Phe Asn Ala Val
     345                 350                 355

 gtg gag gag atc tgc gac tca gtt gat tga g ctgctctctg aagaggaaga     1458
 Val Glu Glu Ile Cys Asp Ser Val Asp 
 360                 365

 ggagaaagcc agagagtcac tcttacctcc ctgtctgctt actcacccac tctgtccttt   1518

 cctcaccaac taacatgtgc cagccaggca gagtcttgtg ctgttcccag aacaggacga   1578

 cagtgaaaag aacactcttg accctacact gaaggctgaa ggcagaagcc acaagaggcc   1638

 ttgagtgcca cccccaggga agaacataaa gggttgcaca atgccaccca tccactcctt   1698

 gccaagtgtt acccagatgg tggaggatgt gaagggattg caccaagcca cattcactct   1758

 ctctgtggcc tttcttcctc tgggcaaaga agggcttcca gtggcctttc ctcactctgt   1818

 agtgtttgtg gggataggtt ccatgcaaga acaccttcct cctccatccc ccacttcacc   1878

 ccatcccata ccagttccat ccagggtctg cttaactgcc aagagcaggt cctggagttc   1938

 ccttcacctg cagagtcctt ttcatgacct aggaggtctt attcaaagcc ctcattgaca   1998

 gaggaggaaa caggccaagg caggacatgg ctggaccatg gtgatacagc tctgtgtgat   2058

 tcaagttctg gcagagcttg taaggctaga gcccaggtct gccgacaccc tgtgcttgtt   2118

 gcacacttga tttgctaagg ctggagacag gcaccattgc catggggctg gtcctagtca   2178

 ctggccgagg ataagcccgt ccctgtccca cattctagcc ccactatgcg ggggtgctgt   2238

 tgtcctgcct gtgtctcatc cccggctgcc taagctaggg acactcaagt gcttccttcc   2298

 ttgccccatc ttcctcccaa ctggaggcct ctgagcctcc cctgtgcctt gggccctgaa   2358

 gccccatatg tagtatagag caaaggtggc tcctggtgaa gagagggtgg aaaggccctt   2418

 cagccccagg gccatgtctg ggttctccat gcccatcagt ctctgcagtt tctctacctg   2478

 cccccagagc tgaggccatc tgcaagcccc tgcccatggc ccaatgggga gcctccagcc   2538

 acaagttccc tgtccttatc agccactggg tggttcccac tgcatgaccc tctatccctg   2598

 ccatctgtcc ccatggtttc cagctcaatc cacccctgac ccatctgtca gctttttccc   2658

 agggagccgt ttcaggggtt ctgggcagta ggctgggcct ggcctcagaa cctggtggct   2718

 cctgcctgct ccttcacttt tgtaaaacca tccccttcac cagaatggta ttaactcctg   2778

 gtgctttgta ctactggtcc agctgccctg ggctcctttt ctatattaat aaagaaacga   2838

 gtaaaaatta ccggtgggga tgatgtttaa aattgctctg atcactggtg gtgctgaatt   2898

 cgcaacagcc tgtgtgatgc ctgagagaag ggagtcctga gggttgcctg cctacccacg   2958

 actccttctc cttttagtgt ggcgtttgcc cgctagaccc agcccagagt ccaggtcagc   3018

 acaggccctc tcagccaacc actcatgaca aatgaggagt cgagatccac agtgtggatg   3078

 gggcaagccc cagttcacag tagagaggtg gagcttagta cttcctgctg cccattagac   3138

 accctttctt cctaagttca agggaagccc acacatgtac tgctccctgc atcctgctct   3198

 aacttcctct catcctctgg atctcagctc aaatattcct tatgcagaga tgccttcccc   3258

 tgattcccta aactagactc ggacccctct gttctgcatc tctgtggcat atcatctgcc   3318

 ccttttgtaa aacttataaa cttgtggtta cttgtttagc gtctctttcc tccccagacc   3378

 ataagcaaca taaagacaaa gggtacatct agcacatagt tcgtgttcaa taaatgtttg   3438

 ttttcatcat gccacgggaa gtgagatata cccagtattc aaaaaagtgt tcaaatcatt   3498

 actaacagtg tttgctctgt gctggctgag tccagctggg cccagaattc cacggttcta   3558

 aatggcgcat attccatgtg cataggctga ttgaaaatgt attaaaccta aattttaaaa   3618

 aaaaaagcac atgatactac acatgtcatg atgaatgaat agacagaact cctcctgaat   3678

 ataattacaa agttctgatc catctcaaaa aaaaaaaaaa                         3718




      <210> 129
      <211> 3177
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(2515)

      <400> 129
 ccacgatttc gtggagacgg agatcgagcg ctgccgcttc gagtgccagt gggagcggat     60

 ccctgagctc gtcaagcagc tgtcggccaa gctcatcgcc aacgatgac    atg gca     115
                                                          Met Ala
                                                            1

 gag ctt ctc ctc ggg gag tcg aag ctg gag cag tac ctg aag gaa cac      163
 Glu Leu Leu Leu Gly Glu Ser Lys Leu Glu Gln Tyr Leu Lys Glu His
           5                  10                  15

 ccc ctg agg cag ggg gcc agt ccc cga ggc ccc aag ccc cag ctg act      211
 Pro Leu Arg Gln Gly Ala Ser Pro Arg Gly Pro Lys Pro Gln Leu Thr
      20                  25                  30

 gag gtc cgc aag cat ctg acc gcc gcc ctg gac cga ggg aac ctt aag      259
 Glu Val Arg Lys His Leu Thr Ala Ala Leu Asp Arg Gly Asn Leu Lys
  35                  40                  45                  50

 tca gaa ttc cta caa gaa tcc aat ctg atc atg gcc aag ttg aat tat      307
 Ser Glu Phe Leu Gln Glu Ser Asn Leu Ile Met Ala Lys Leu Asn Tyr
                  55                  60                  65

 gtg gaa ggt gat tat aaa gaa gct ctg aac att tac gcc cgg gtg ggc      355
 Val Glu Gly Asp Tyr Lys Glu Ala Leu Asn Ile Tyr Ala Arg Val Gly
              70                  75                  80

 ctg gac gat ctg cca ctg aca gct gtc ccg ccc tac agg ctg cgg gtg      403
 Leu Asp Asp Leu Pro Leu Thr Ala Val Pro Pro Tyr Arg Leu Arg Val
          85                  90                  95

 atc gca gaa gcc tac gct acc aaa gga ctt tgt ttg gag aag ctg cct      451
 Ile Ala Glu Ala Tyr Ala Thr Lys Gly Leu Cys Leu Glu Lys Leu Pro
     100                 105                 110

 att tct tct tct acc agt aat ctc cat gtg gac cgg gaa cag gat gtc      499
 Ile Ser Ser Ser Thr Ser Asn Leu His Val Asp Arg Glu Gln Asp Val
 115                 120                 125                 130

 atc acc tgt tat gag aaa gca ggg gac atc gca ctc ctg tat ctc caa      547
 Ile Thr Cys Tyr Glu Lys Ala Gly Asp Ile Ala Leu Leu Tyr Leu Gln
                 135                 140                 145

 gag ata gaa agg gta ata ctt tct aat att caa aac aga agc cct aag      595
 Glu Ile Glu Arg Val Ile Leu Ser Asn Ile Gln Asn Arg Ser Pro Lys
             150                 155                 160

 cct ggc cct gct ccc cac gat caa gaa cta ggt ttt ttc cta gaa aca      643
 Pro Gly Pro Ala Pro His Asp Gln Glu Leu Gly Phe Phe Leu Glu Thr
         165                 170                 175

 gga ctt cag aga gcc cat gtc ctc tat ttc aaa aat ggg aac ttg aca      691
 Gly Leu Gln Arg Ala His Val Leu Tyr Phe Lys Asn Gly Asn Leu Thr
     180                 185                 190

 aga gga gtc gga aga ttt aga gag ctt ctc aga gca gtt gaa aca aga      739
 Arg Gly Val Gly Arg Phe Arg Glu Leu Leu Arg Ala Val Glu Thr Arg
 195                 200                 205                 210

 acg act caa aac ctg cga atg aca ata gcc agg cag ctg gca gag atc      787
 Thr Thr Gln Asn Leu Arg Met Thr Ile Ala Arg Gln Leu Ala Glu Ile
                 215                 220                 225

 ttg ttg cgg ggt atg tgt gag cag agc tac tgg aac cct ctg gag gat      835
 Leu Leu Arg Gly Met Cys Glu Gln Ser Tyr Trp Asn Pro Leu Glu Asp
             230                 235                 240

 cca ccg tgc cag tca cct ctg gac gat cct ctc cgc aaa gga gca aac      883
 Pro Pro Cys Gln Ser Pro Leu Asp Asp Pro Leu Arg Lys Gly Ala Asn
         245                 250                 255

 aca aaa acc tac act ctc act cgg aga gcc cgt gtc tac tca gga gag      931
 Thr Lys Thr Tyr Thr Leu Thr Arg Arg Ala Arg Val Tyr Ser Gly Glu
     260                 265                 270

 aac att ttt tgt cct caa gaa aat acg gaa gaa gcc ctg ttg tta ttg      979
 Asn Ile Phe Cys Pro Gln Glu Asn Thr Glu Glu Ala Leu Leu Leu Leu
 275                 280                 285                 290

 ctg att agt gaa tca atg gcc aac cgg gac gct gtg ctg agc agg ata     1027
 Leu Ile Ser Glu Ser Met Ala Asn Arg Asp Ala Val Leu Ser Arg Ile
                 295                 300                 305

 cct gaa cac aag agt gac cgc ctc atc agt ctg cag agt gca tct gtg     1075
 Pro Glu His Lys Ser Asp Arg Leu Ile Ser Leu Gln Ser Ala Ser Val
             310                 315                 320

 gtc tat gac tta ctc acc att gct ctt gga aga aga ggc cag tat gag     1123
 Val Tyr Asp Leu Leu Thr Ile Ala Leu Gly Arg Arg Gly Gln Tyr Glu
         325                 330                 335

 atg ctg tca gag tgc cta gaa aga gcc atg aag ttt gcc ttt gag gaa     1171
 Met Leu Ser Glu Cys Leu Glu Arg Ala Met Lys Phe Ala Phe Glu Glu
     340                 345                 350

 ttc cac ctg tgg tac cag ttt gct ctg tcc ctg atg gct gct gga aaa     1219
 Phe His Leu Trp Tyr Gln Phe Ala Leu Ser Leu Met Ala Ala Gly Lys
 355                 360                 365                 370

 tct gcc cgt gcc gtg aag gtg ctg aaa gag tgt atc cgc ctg aag ccg     1267
 Ser Ala Arg Ala Val Lys Val Leu Lys Glu Cys Ile Arg Leu Lys Pro
                 375                 380                 385

 gac gat gcc acc atc cct ctc ctc gct gcc aag ctc tgc atg ggc tcc     1315
 Asp Asp Ala Thr Ile Pro Leu Leu Ala Ala Lys Leu Cys Met Gly Ser
             390                 395                 400

 ctg cac tgg ttg gaa gag gct gaa aag ttt gcc aaa act gtc gtt gat     1363
 Leu His Trp Leu Glu Glu Ala Glu Lys Phe Ala Lys Thr Val Val Asp
         405                 410                 415

 gtg gga gag aaa acg tca gag ttc aag gcc aaa ggc tac tta gct ctg     1411
 Val Gly Glu Lys Thr Ser Glu Phe Lys Ala Lys Gly Tyr Leu Ala Leu
     420                 425                 430

 ggg ctc acg tac agt ctg cag gcc act gac gct tct ttg cga ggg atg     1459
 Gly Leu Thr Tyr Ser Leu Gln Ala Thr Asp Ala Ser Leu Arg Gly Met
 435                 440                 445                 450

 cag gag gtc cta cag aga aag gcg ctt ctt gca ttt cag agg gcc cac     1507
 Gln Glu Val Leu Gln Arg Lys Ala Leu Leu Ala Phe Gln Arg Ala His
                 455                 460                 465

 agc ctg tca ccc aca gat cac caa gca gct ttc tac ctg gct ctg cag     1555
 Ser Leu Ser Pro Thr Asp His Gln Ala Ala Phe Tyr Leu Ala Leu Gln
             470                 475                 480

 ctt gcc atc tcc aga cag atc cca gag gct ctg ggg tat gtc cgc caa     1603
 Leu Ala Ile Ser Arg Gln Ile Pro Glu Ala Leu Gly Tyr Val Arg Gln
         485                 490                 495

 gct ctt cag ctt caa ggt gac gat gcc aac tcc ctg cac ctc ctt gcc     1651
 Ala Leu Gln Leu Gln Gly Asp Asp Ala Asn Ser Leu His Leu Leu Ala
     500                 505                 510

 ctc ctg ctg tca gca cag aag cat tac cat gac gct ctg aac atc atc     1699
 Leu Leu Leu Ser Ala Gln Lys His Tyr His Asp Ala Leu Asn Ile Ile
 515                 520                 525                 530

 gac atg gcc ctg agt gaa tac cca gaa aat ttc ata cta ctg ttt tcc     1747
 Asp Met Ala Leu Ser Glu Tyr Pro Glu Asn Phe Ile Leu Leu Phe Ser
                 535                 540                 545

 aaa gtg aag ttg cag tca ctc tgc cga ggc ccg gac gag gca ctg ctg     1795
 Lys Val Lys Leu Gln Ser Leu Cys Arg Gly Pro Asp Glu Ala Leu Leu
             550                 555                 560

 act tgt aag cac atg ctg cag ata tgg aaa tcc tgc tac aac ctc acc     1843
 Thr Cys Lys His Met Leu Gln Ile Trp Lys Ser Cys Tyr Asn Leu Thr
         565                 570                 575

 aac ccc agt gat tct gga cgt ggg agc agc ctc tta gat aga acc att     1891
 Asn Pro Ser Asp Ser Gly Arg Gly Ser Ser Leu Leu Asp Arg Thr Ile
     580                 585                 590

 gct gac aga cga cag ctt aat aca att act ttg cca gac ttc agc gat     1939
 Ala Asp Arg Arg Gln Leu Asn Thr Ile Thr Leu Pro Asp Phe Ser Asp
 595                 600                 605                 610

 ccc gag aca ggc tcc gtc cat gcc aca tcg gta gca gcc tca aga gtg     1987
 Pro Glu Thr Gly Ser Val His Ala Thr Ser Val Ala Ala Ser Arg Val
                 615                 620                 625

 gag cag gca ctg tcg gaa gtg gct tcg tct ctg cag agc agt gcc cct     2035
 Glu Gln Ala Leu Ser Glu Val Ala Ser Ser Leu Gln Ser Ser Ala Pro
             630                 635                 640

 aag cag ggc ccg ctg cac ccc tgg atg acg ctg gca cag atc tgg ctc     2083
 Lys Gln Gly Pro Leu His Pro Trp Met Thr Leu Ala Gln Ile Trp Leu
         645                 650                 655

 cat gca gct gaa gtc tat atc ggc atc ggg aag cct gca gaa gcc aca     2131
 His Ala Ala Glu Val Tyr Ile Gly Ile Gly Lys Pro Ala Glu Ala Thr
     660                 665                 670

 gcc tgt acc caa gaa gct gcc aac ctc ttc cca atg tcc cac aat gtc     2179
 Ala Cys Thr Gln Glu Ala Ala Asn Leu Phe Pro Met Ser His Asn Val
 675                 680                 685                 690

 ctc tac atg cgc ggc cag att gct gag ctc cgg gga agc atg gac gag     2227
 Leu Tyr Met Arg Gly Gln Ile Ala Glu Leu Arg Gly Ser Met Asp Glu
                 695                 700                 705

 gcg cgg cgg tgg tat gaa gag gcc tta gcc atc agc ccc acc cac gtg     2275
 Ala Arg Arg Trp Tyr Glu Glu Ala Leu Ala Ile Ser Pro Thr His Val
             710                 715                 720

 aag agc atg cag cga ctg gcc ctg atc ctt cac cag cta ggc cgc tac     2323
 Lys Ser Met Gln Arg Leu Ala Leu Ile Leu His Gln Leu Gly Arg Tyr
         725                 730                 735

 agt ctg gcg gag aag atc ctc cgg gac gcg gtg cag gtg aac tcg aca     2371
 Ser Leu Ala Glu Lys Ile Leu Arg Asp Ala Val Gln Val Asn Ser Thr
     740                 745                 750

 gcc cac gag gtc tgg aac ggg ctg ggc gag gtc ctc caa gct cag ggc     2419
 Ala His Glu Val Trp Asn Gly Leu Gly Glu Val Leu Gln Ala Gln Gly
 755                 760                 765                 770

 aac gat gcg gcg gct acg gag tgc ttc ctg aca gcc ttg gag ctg gag     2467
 Asn Asp Ala Ala Ala Thr Glu Cys Phe Leu Thr Ala Leu Glu Leu Glu
                 775                 780                 785

 gcc agc agc ccc gcc gtg ccc ttc acc atc atc ccc cgc gtg ctc tga     2515
 Ala Ser Ser Pro Ala Val Pro Phe Thr Ile Ile Pro Arg Val Leu 
             790                 795                 800

 gcaggcgcct gccagcctca cctgccgctc aggcctcaga ggcctgccgg gcaccagggc   2575

 ttgtgccatc gccccaaggg gatgaatctg ccgcactgag gccagggacg agtgttcagt   2635

 gggccacagt gaaccaacca aaccaacccc gaatcatcgc tctcgccatg tgcgtttctc   2695

 ttgttttttt tgccagccca atggtagttt ctgaacctat tgacattgtt caaaatggat   2755

 catgtgccat attttgttag ttgacatctg agttttcagt aaaatgatta tggaattaat   2815

 cagcaaatgt agaagaatat attcaaagtt aaaattcagt ggcagcacag attattttta   2875

 tcagagctgt aaagaaaaca actgtccttt tctccccacc acccctcctg ccccactttg   2935

 gcccagaaac caaatgtgaa cttcctgtct cccacctcag cactagtcca tgccaggaca   2995

 ccagctgaca atttcttggt tttactgtca ataattgtac catgtgatca attactgtcc   3055

 tcacttaaaa caaagcctga gtccgagaat atttatattt taccaatata tgcctgttac   3115

 aagagaagga aatatgagtt atttaagctt aactttttta tgtgaattca gagtttattt   3175

 aa                                                                  3177




      <210> 130
      <211> 1019
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (519)..(740)

      <400> 130
 tcgcgatcta gaactagatt caacctaatt ttcagtaaga agtgattaaa ataatgacat     60

 gctaaaaggc aaatttcaag ggaagaaatg taaaagaatt ttacaaatgc tttccaagtg    120

 atgaatatgc tcagttaatt tcatatgctc ctggattgat agcagtattt ggcaatacct    180

 atctgtatga gaagacattt ttaaagatga aatgtgtaaa atcttattac cattagtatt    240

 aatggttaat gatggttaat gataaccatt aataggcaat catttacaac tgattttgat    300

 cacagggaac acttacttag aaccctgatt agaggcaatg ttattctcac caaaaaaggc    360

 attacaaaaa attgggctat attttgaatt ttgtcaatta aaaaagcgtg ggagcagtgt    420

 gaaggagaag aggcaagaac gacccctgga ccgaccaaag cccgcgcgct gctgcgtccc    480

 acacccggtg cccacatccc gccgccgccg ccgccgcc    atg ccc aag aga aag     533
                                              Met Pro Lys Arg Lys
                                                1               5

 act gaa ggg gat gct aaa gga gat aaa gcc aag gtg aag gat gaa tca      581
 Thr Glu Gly Asp Ala Lys Gly Asp Lys Ala Lys Val Lys Asp Glu Ser
                  10                  15                  20

 cag aga aga tct gcg agg ttg tct gct aaa cct gct cct cca aag cca      629
 Gln Arg Arg Ser Ala Arg Leu Ser Ala Lys Pro Ala Pro Pro Lys Pro
              25                  30                  35

 gag ccc aag cct aaa aag gcc cct gca aag aag gga gag aag gta ccc      677
 Glu Pro Lys Pro Lys Lys Ala Pro Ala Lys Lys Gly Glu Lys Val Pro
          40                  45                  50

 aaa ggg aaa aag aga aaa gct gat gct ggc aag gag cgg gaa ggt gct      725
 Lys Gly Lys Lys Arg Lys Ala Asp Ala Gly Lys Glu Arg Glu Gly Ala
      55                  60                  65

 gga gat ccc aag tga agtgtgtgca ttttttataa ctgtacttct ggtgactgta      780
 Gly Asp Pro Lys 
  70

 cagtttgaaa tattctttat caagttttat aaaaatgcag aattttgttt tacttttttt    840

 aagctatgtt gttagcacac agaacacttc attgttgttt ttgggggaag gggtatgtgt    900

 cactaataga atatctctga agctggattg atacggggaa aacatctttc ccttctagtt    960

 ttgagagact tcctcttggc tcccaggagg agggatttcc tgactttgac acacatggc    1019




      <210> 131
      <211> 2623
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (406)..(1965)

      <220>
      <221> misc_feature
      <222> (1)...(2623)
      <223> n = a,t,c or g

      <400> 131
 tataagattt aataggtcac ttaaggaatt ggcctcaagc caagattcgg cacatgagtt     60

 ccccggccgg gttccacctt gtcagggggg tctttaagcc tcagccaaac tcgggcttcc    120

 catggaagcc agctgtgccc cagagagcca ggagaagttg agtgggctga tggccccggt    180

 gccgcccggg gccctgagcc catcccgctc ctagcgctgc ctaaaggcca cgggcgccgg    240

 cgccccaanc cngggcgcgc cgcctccgtc cgcccttccc cgggggcttc gcccgacctg    300

 ccccccgccc gtttgccagc gctcaggcag gagctctgga ctgggcgcgc cgccgccctg    360

 gagtgaggga agcccagtgg aagggggtcc cgggagccgg ctgcg    atg gac gcc     414
                                                      Met Asp Ala
                                                        1

 gtc ttg gaa ccc ttc ccg gcc gac agg ctg ttc ccc gga tcc agc ttc      462
 Val Leu Glu Pro Phe Pro Ala Asp Arg Leu Phe Pro Gly Ser Ser Phe
       5                  10                  15

 ctg gac ttg ggg gat ctg aac gag tcg gac ttc ctc aac aat gcg cac      510
 Leu Asp Leu Gly Asp Leu Asn Glu Ser Asp Phe Leu Asn Asn Ala His
  20                  25                  30                  35

 ttt cct gag cac ctg gac cac ttt acg gag aac atg gag gac ttc tcc      558
 Phe Pro Glu His Leu Asp His Phe Thr Glu Asn Met Glu Asp Phe Ser
                  40                  45                  50

 aat gac ctg ttc agc agc ttc ttt gat gac cct gtg ctg gat gag aag      606
 Asn Asp Leu Phe Ser Ser Phe Phe Asp Asp Pro Val Leu Asp Glu Lys
              55                  60                  65

 agc cct cta ttg gac atg gaa ctg gac tcc cct acg cca ggc atc cag      654
 Ser Pro Leu Leu Asp Met Glu Leu Asp Ser Pro Thr Pro Gly Ile Gln
          70                  75                  80

 gcg gag cac agc tac tcc ctg agc ggc gac tca gcg ccc cag agc ccc      702
 Ala Glu His Ser Tyr Ser Leu Ser Gly Asp Ser Ala Pro Gln Ser Pro
      85                  90                  95

 ctt gtg ccc atc aag atg gag gac acc acc caa gat gca gag cat gga      750
 Leu Val Pro Ile Lys Met Glu Asp Thr Thr Gln Asp Ala Glu His Gly
 100                 105                 110                 115

 gca tgg gcg ctg gga cac aaa ctg tgc tcc atc atg gtg aag cag gag      798
 Ala Trp Ala Leu Gly His Lys Leu Cys Ser Ile Met Val Lys Gln Glu
                 120                 125                 130

 cag agc ccg gag ctg ccc gtg gac cct ctg gct gcc ccc tcg gcc atg      846
 Gln Ser Pro Glu Leu Pro Val Asp Pro Leu Ala Ala Pro Ser Ala Met
             135                 140                 145

 gct gcc gcg gcc acc atg gcc acc acc ccg ctg ctg ggc ctc agc ccc      894
 Ala Ala Ala Ala Thr Met Ala Thr Thr Pro Leu Leu Gly Leu Ser Pro
         150                 155                 160

 ttg tcc agg ctg ccc atc ccc cac cag gcc ccg gga gag atg act cag      942
 Leu Ser Arg Leu Pro Ile Pro His Gln Ala Pro Gly Glu Met Thr Gln
     165                 170                 175

 ctg cca gtg atc aaa gca gag cct ctg gag gtg aac cag ttc ctc aaa      990
 Leu Pro Val Ile Lys Ala Glu Pro Leu Glu Val Asn Gln Phe Leu Lys
 180                 185                 190                 195

 gtg aca ccg gag gac ctg gtg cag atg cct ccg acg ccc ccc agc agc     1038
 Val Thr Pro Glu Asp Leu Val Gln Met Pro Pro Thr Pro Pro Ser Ser
                 200                 205                 210

 cat ggc agt gac agc gac ggc tcc cag agt ccc cgc tct ctg ccc ccc     1086
 His Gly Ser Asp Ser Asp Gly Ser Gln Ser Pro Arg Ser Leu Pro Pro
             215                 220                 225

 tcc agc cct gtc agg ccc atg gcg cgc tcc tcc acg gcc atc tcc acc     1134
 Ser Ser Pro Val Arg Pro Met Ala Arg Ser Ser Thr Ala Ile Ser Thr
         230                 235                 240

 tcc cca ctc ctc act gcc cct cac aaa tta cag ggg aca tca ggg cca     1182
 Ser Pro Leu Leu Thr Ala Pro His Lys Leu Gln Gly Thr Ser Gly Pro
     245                 250                 255

 ctg ctc ctg aca gag gag gag aag cgg acc ctg att gct gag ggc tac     1230
 Leu Leu Leu Thr Glu Glu Glu Lys Arg Thr Leu Ile Ala Glu Gly Tyr
 260                 265                 270                 275

 ccc atc ccc aca aaa ctc ccc ctc acc aaa gcc gag gag aag gcc ttg     1278
 Pro Ile Pro Thr Lys Leu Pro Leu Thr Lys Ala Glu Glu Lys Ala Leu
                 280                 285                 290

 aag aga gtc cgg agg aaa atc aag aac aag atc tca gcc cag gag agc     1326
 Lys Arg Val Arg Arg Lys Ile Lys Asn Lys Ile Ser Ala Gln Glu Ser
             295                 300                 305

 cgt cgt aag aag aag gag tat gtg gag tgt cta gaa aag aag gtg gag     1374
 Arg Arg Lys Lys Lys Glu Tyr Val Glu Cys Leu Glu Lys Lys Val Glu
         310                 315                 320

 aca ttt aca tct gag aac aat gaa ctg tgg aag aag gtg gag acc ctg     1422
 Thr Phe Thr Ser Glu Asn Asn Glu Leu Trp Lys Lys Val Glu Thr Leu
     325                 330                 335

 gag aat gcc aac agg acc ctg ctc cag cag ctg cag aaa ctc cag act     1470
 Glu Asn Ala Asn Arg Thr Leu Leu Gln Gln Leu Gln Lys Leu Gln Thr
 340                 345                 350                 355

 ctg gtc acc aac aag atc tcc aga cct tac aag atg gcc gcc acc cag     1518
 Leu Val Thr Asn Lys Ile Ser Arg Pro Tyr Lys Met Ala Ala Thr Gln
                 360                 365                 370

 act ggg acc tgc ctc atg gtg gca gcc ttg tgc ttt gtt ctg gtg ctg     1566
 Thr Gly Thr Cys Leu Met Val Ala Ala Leu Cys Phe Val Leu Val Leu
             375                 380                 385

 ggc tcc ctc gtg ccc tgc ctt ccc gag ttc tcc tcc ggc tcc cag act     1614
 Gly Ser Leu Val Pro Cys Leu Pro Glu Phe Ser Ser Gly Ser Gln Thr
         390                 395                 400

 gtg aag gaa gac ccc ctg gcc aca gac ggc gtc tac acg gcc agc cag     1662
 Val Lys Glu Asp Pro Leu Ala Thr Asp Gly Val Tyr Thr Ala Ser Gln
     405                 410                 415

 atg ccc tcc cga agc ctc cta ttc tac gat gac ggg gca ggc tta tgg     1710
 Met Pro Ser Arg Ser Leu Leu Phe Tyr Asp Asp Gly Ala Gly Leu Trp
 420                 425                 430                 435

 gaa gat ggc cgc agc acc ctg ctg ccc atg gag ccc cca gat ggc tgg     1758
 Glu Asp Gly Arg Ser Thr Leu Leu Pro Met Glu Pro Pro Asp Gly Trp
                 440                 445                 450

 gaa atc aac ccc ggg ggg ccg gca gag cag cgg ccc cgg gac cac ctg     1806
 Glu Ile Asn Pro Gly Gly Pro Ala Glu Gln Arg Pro Arg Asp His Leu
             455                 460                 465

 cag cat gat cac ctg gac agc acc cac gag acc acc aag tac ctg agt     1854
 Gln His Asp His Leu Asp Ser Thr His Glu Thr Thr Lys Tyr Leu Ser
         470                 475                 480

 gag gcc tgg cct aaa gac ggt gga aac ggc acc agc ccc gac ttc tcc     1902
 Glu Ala Trp Pro Lys Asp Gly Gly Asn Gly Thr Ser Pro Asp Phe Ser
     485                 490                 495

 cac tcc aag gag tgg ttc cac gac agg gat ctg ggc ccc aac acc acc     1950
 His Ser Lys Glu Trp Phe His Asp Arg Asp Leu Gly Pro Asn Thr Thr
 500                 505                 510                 515

 atc aaa ctc tcc tag gccatgccaa gacccaggac ataggacgga cccctggtac     2005
 Ile Lys Leu Ser 


 ccagaagagg agttcttgct cactaacccg gatccgcctc gtgcccctgc ctcctggagc   2065

 ttcccattcc aggagaaaag gctccacttc ccagcccttc cttgcccctg acatttggac   2125

 tcttcccttg ggccgaccac tctgttctca ttctccttcc caccaacatc catccgtcct   2185

 tctcagacaa accactcact gggtacccca cctcctctct catatgccca acacgaccac   2245

 tgcctccctg cccccacacc tgcacccaaa cagacacatc aacgcacccc actcacagac   2305

 accccttacc ccacccccac tgtacagaga ccaagaacag aaattgtttg taaataatga   2365

 accttatttt ttattattgc caatccccta agatattgta ttttacaaat ctccctcttc   2425

 ccttcgcccc tcccttgttt tatattttat gaagttagtg cgggctttgc tgctccctgg   2485

 cccaggaaag agggactacc tgaccctcac ctggcacccc cctgctgctg cccaagccgc   2545

 tgggcctttt taattgccaa actgctctct tcatcagctc agcacatgct ttaagaaagc   2605

 aaaaccaaaa aaaaaaaa                                                 2623




      <210> 132
      <211> 5559
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2799)

      <400> 132
  atg gct gtg gtc atc cgt ttg caa ggt ctc cca att gtg gcg ggg acc      48
  Met Ala Val Val Ile Arg Leu Gln Gly Leu Pro Ile Val Ala Gly Thr
    1               5                  10                  15

 atg gac att cgc cac ttc ttc tct gga ttg acc att cct gat ggg ggc       96
 Met Asp Ile Arg His Phe Phe Ser Gly Leu Thr Ile Pro Asp Gly Gly
              20                  25                  30

 gtg cat att gta ggg ggt gaa ctg ggt gag gct ttc atc gtt ttt gcc      144
 Val His Ile Val Gly Gly Glu Leu Gly Glu Ala Phe Ile Val Phe Ala
          35                  40                  45

 act gat gaa gat gca agg ctt ggt atg atg cgc aca ggt ggt aca att      192
 Thr Asp Glu Asp Ala Arg Leu Gly Met Met Arg Thr Gly Gly Thr Ile
      50                  55                  60

 aaa ggg tca aaa gta aca cta ttg ttg agt agt aag acg gaa atg cag      240
 Lys Gly Ser Lys Val Thr Leu Leu Leu Ser Ser Lys Thr Glu Met Gln
  65                  70                  75                  80

 aat atg att gaa ctg agt cgt agg cgt ttt gaa act gcc aac tta gat      288
 Asn Met Ile Glu Leu Ser Arg Arg Arg Phe Glu Thr Ala Asn Leu Asp
                  85                  90                  95

 ata cca cca gca aat gcc agt aga tca gga cca cca cct agc tca gga      336
 Ile Pro Pro Ala Asn Ala Ser Arg Ser Gly Pro Pro Pro Ser Ser Gly
             100                 105                 110

 atg agt agc agg gta aac ttg ccc aca aca gta tcc aac ttt aat aat      384
 Met Ser Ser Arg Val Asn Leu Pro Thr Thr Val Ser Asn Phe Asn Asn
         115                 120                 125

 cca tca ccc agt gta gtt act gcc acc act tct gtt cat gaa agc aac      432
 Pro Ser Pro Ser Val Val Thr Ala Thr Thr Ser Val His Glu Ser Asn
     130                 135                 140

 aaa aac ata cag aca ttt tcc aca gcc agc gta gga aca gct cct cca      480
 Lys Asn Ile Gln Thr Phe Ser Thr Ala Ser Val Gly Thr Ala Pro Pro
 145                 150                 155                 160

 aat atg ggg gct tcc ttt ggg agc cca acg ttt agc tca act gtt cca      528
 Asn Met Gly Ala Ser Phe Gly Ser Pro Thr Phe Ser Ser Thr Val Pro
                 165                 170                 175

 agc aca gcc tct cca atg aac aca gtc ccg ccg cca cca att cct cca      576
 Ser Thr Ala Ser Pro Met Asn Thr Val Pro Pro Pro Pro Ile Pro Pro
             180                 185                 190

 att cca gcg atg cca tct ctg cca cca atg cca tcc att ccc cca att      624
 Ile Pro Ala Met Pro Ser Leu Pro Pro Met Pro Ser Ile Pro Pro Ile
         195                 200                 205

 cca gtt cct cct cca gta cct aca ttg cct cct gtg cct cct gtg ccc      672
 Pro Val Pro Pro Pro Val Pro Thr Leu Pro Pro Val Pro Pro Val Pro
     210                 215                 220

 ccg att ccc cca gtt cct tct gtg cca ccc atg acc cca ctg cca ccc      720
 Pro Ile Pro Pro Val Pro Ser Val Pro Pro Met Thr Pro Leu Pro Pro
 225                 230                 235                 240

 atg tcg ggc atg ccg ccc ttg aat ccg cca cct gtg gca cct cta cct      768
 Met Ser Gly Met Pro Pro Leu Asn Pro Pro Pro Val Ala Pro Leu Pro
                 245                 250                 255

 gct gga atg aat ggc tct gga gca cct atg aat ttg aac aat aat ctg      816
 Ala Gly Met Asn Gly Ser Gly Ala Pro Met Asn Leu Asn Asn Asn Leu
             260                 265                 270

 aat cct atg ttt ctt ggt ccg ttg aat cct gtt aac cct atc cag atg      864
 Asn Pro Met Phe Leu Gly Pro Leu Asn Pro Val Asn Pro Ile Gln Met
         275                 280                 285

 aac tct cag agc agt gtg aag cca ctc ccc atc aac cct gat gat ctg      912
 Asn Ser Gln Ser Ser Val Lys Pro Leu Pro Ile Asn Pro Asp Asp Leu
     290                 295                 300

 tat gtc agt gtg cat gga atg ccc ttt tct gca atg gaa aat gat gtc      960
 Tyr Val Ser Val His Gly Met Pro Phe Ser Ala Met Glu Asn Asp Val
 305                 310                 315                 320

 aga gat ttt ttt cat ggg ctc cgt gtt gat gca gtg cat ttg ttg aaa     1008
 Arg Asp Phe Phe His Gly Leu Arg Val Asp Ala Val His Leu Leu Lys
                 325                 330                 335

 gat cat gta ggt cga aat aat ggg aat gga ttg gtt aag ttt ctc tcc     1056
 Asp His Val Gly Arg Asn Asn Gly Asn Gly Leu Val Lys Phe Leu Ser
             340                 345                 350

 cct caa gat aca ttt gaa gct ttg aaa cga aac aga atg ctg atg att     1104
 Pro Gln Asp Thr Phe Glu Ala Leu Lys Arg Asn Arg Met Leu Met Ile
         355                 360                 365

 caa cgc tat gtg gaa gtt agc cct gcc aca gaa aga cag tgg gta gct     1152
 Gln Arg Tyr Val Glu Val Ser Pro Ala Thr Glu Arg Gln Trp Val Ala
     370                 375                 380

 gct gga ggc cat atc act ttt aag caa aat atg gga cct tct gga caa     1200
 Ala Gly Gly His Ile Thr Phe Lys Gln Asn Met Gly Pro Ser Gly Gln
 385                 390                 395                 400

 act cat ccc cct cct cag aca ctt ccc agg tca aaa tcg ccc agt ggg     1248
 Thr His Pro Pro Pro Gln Thr Leu Pro Arg Ser Lys Ser Pro Ser Gly
                 405                 410                 415

 cag aaa aga tca agg tca aga tca cca cat gag gct ggt ttt tgt gtt     1296
 Gln Lys Arg Ser Arg Ser Arg Ser Pro His Glu Ala Gly Phe Cys Val
             420                 425                 430

 tac ttg aaa ggg cta cca ttt gaa gca gaa aac aaa cat gtc att gat     1344
 Tyr Leu Lys Gly Leu Pro Phe Glu Ala Glu Asn Lys His Val Ile Asp
         435                 440                 445

 ttt ttt aaa aag ctg gat att gtg gaa gat agt att tat ata gct tat     1392
 Phe Phe Lys Lys Leu Asp Ile Val Glu Asp Ser Ile Tyr Ile Ala Tyr
     450                 455                 460

 gga ccc aat ggg aaa gca act ggc gaa ggc ttt gta gag ttc aga aat     1440
 Gly Pro Asn Gly Lys Ala Thr Gly Glu Gly Phe Val Glu Phe Arg Asn
 465                 470                 475                 480

 gag gct gac tat aag gct gct ctg tgt cgt cat aaa cag tac atg ggc     1488
 Glu Ala Asp Tyr Lys Ala Ala Leu Cys Arg His Lys Gln Tyr Met Gly
                 485                 490                 495

 aat cgc ttt att caa gtt cat cca att act aag aaa ggt atg cta gaa     1536
 Asn Arg Phe Ile Gln Val His Pro Ile Thr Lys Lys Gly Met Leu Glu
             500                 505                 510

 aag ata gat atg att cga aaa aga ctg cag aac ttc agc tat gac cag     1584
 Lys Ile Asp Met Ile Arg Lys Arg Leu Gln Asn Phe Ser Tyr Asp Gln
         515                 520                 525

 agg gaa atg ata cta aat cca gag ggg gat gtc aac tct gcc aaa gtc     1632
 Arg Glu Met Ile Leu Asn Pro Glu Gly Asp Val Asn Ser Ala Lys Val
     530                 535                 540

 tgt gcc cac ata aca aat att cca ttc agc att aca aag atg gat gtt     1680
 Cys Ala His Ile Thr Asn Ile Pro Phe Ser Ile Thr Lys Met Asp Val
 545                 550                 555                 560

 ctt cag ttc cta gaa gga atc cca gtg gat gaa aat gct gta cat gtt     1728
 Leu Gln Phe Leu Glu Gly Ile Pro Val Asp Glu Asn Ala Val His Val
                 565                 570                 575

 ctt gtt gat aac aat ggg caa ggt cta gga cag gca ttg gtt cag ttt     1776
 Leu Val Asp Asn Asn Gly Gln Gly Leu Gly Gln Ala Leu Val Gln Phe
             580                 585                 590

 aaa aat gaa gat gat gca cgt aag tct gaa cgc tta cac cgt aaa aaa     1824
 Lys Asn Glu Asp Asp Ala Arg Lys Ser Glu Arg Leu His Arg Lys Lys
         595                 600                 605

 ctt aat ggg aga gaa gct ttt gtt cat gta gtt acc cta gaa gat atg     1872
 Leu Asn Gly Arg Glu Ala Phe Val His Val Val Thr Leu Glu Asp Met
     610                 615                 620

 aga gag att gag aaa aat ccc cct gcc caa gga aaa aag gga tta aag     1920
 Arg Glu Ile Glu Lys Asn Pro Pro Ala Gln Gly Lys Lys Gly Leu Lys
 625                 630                 635                 640

 atg cct gtg cca ggt aat cct gca gtt cca gga atg ccc aat gcg gga     1968
 Met Pro Val Pro Gly Asn Pro Ala Val Pro Gly Met Pro Asn Ala Gly
                 645                 650                 655

 ctg ccc ggt gtg gga ctg ccc agt gca gga ctt ccc ggt gca ggc ctg     2016
 Leu Pro Gly Val Gly Leu Pro Ser Ala Gly Leu Pro Gly Ala Gly Leu
             660                 665                 670

 ccc agc aca gga ctg cct ggt tca gca ata acc agt gca gga ctg cct     2064
 Pro Ser Thr Gly Leu Pro Gly Ser Ala Ile Thr Ser Ala Gly Leu Pro
         675                 680                 685

 ggt gcg gga atg ccc agt gca gga ata cct agt gca gga ggt gaa gag     2112
 Gly Ala Gly Met Pro Ser Ala Gly Ile Pro Ser Ala Gly Gly Glu Glu
     690                 695                 700

 cat gcc ttc ctg act gta gga tca aag gaa gcc aat aat ggg cct cca     2160
 His Ala Phe Leu Thr Val Gly Ser Lys Glu Ala Asn Asn Gly Pro Pro
 705                 710                 715                 720

 ttt aac ttt cct ggt aat ttt ggt gga tca aat gcc ttt ggg cca cca     2208
 Phe Asn Phe Pro Gly Asn Phe Gly Gly Ser Asn Ala Phe Gly Pro Pro
                 725                 730                 735

 atc cct cct cca gga tta gga ggc ggg gcc ttt ggt gat gct agg cct     2256
 Ile Pro Pro Pro Gly Leu Gly Gly Gly Ala Phe Gly Asp Ala Arg Pro
             740                 745                 750

 ggt atg cct tca gtt gga aac agt ggt ttg cct ggt cta gga ctg gat     2304
 Gly Met Pro Ser Val Gly Asn Ser Gly Leu Pro Gly Leu Gly Leu Asp
         755                 760                 765

 gtt ccg ggt ttt gga ggt gga cca aac aat tta agt ggg cca tcg gga     2352
 Val Pro Gly Phe Gly Gly Gly Pro Asn Asn Leu Ser Gly Pro Ser Gly
     770                 775                 780

 ttt gga ggg ggc cct cag aat ttt gga aat ggc cct ggt agc tta ggc     2400
 Phe Gly Gly Gly Pro Gln Asn Phe Gly Asn Gly Pro Gly Ser Leu Gly
 785                 790                 795                 800

 ggt ccc ccg ggg ttt gga agt ggc cct cct ggt ctt gga agt gcc cct     2448
 Gly Pro Pro Gly Phe Gly Ser Gly Pro Pro Gly Leu Gly Ser Ala Pro
                 805                 810                 815

 ggg cat ttg ggt ggg cca cca gct ttt ggg cct ggc ccc ggc ccc ggc     2496
 Gly His Leu Gly Gly Pro Pro Ala Phe Gly Pro Gly Pro Gly Pro Gly
             820                 825                 830

 ccc ggc cct ggc cca atc cat att ggt ggt ccc cct ggc ttt gca tct     2544
 Pro Gly Pro Gly Pro Ile His Ile Gly Gly Pro Pro Gly Phe Ala Ser
         835                 840                 845

 agt tct gga aaa cca gga ccg aca gta att aaa gtg caa aac atg ccc     2592
 Ser Ser Gly Lys Pro Gly Pro Thr Val Ile Lys Val Gln Asn Met Pro
     850                 855                 860

 ttt act gtg tct att gat gag att tta gat ttc ttt tat ggc tat caa     2640
 Phe Thr Val Ser Ile Asp Glu Ile Leu Asp Phe Phe Tyr Gly Tyr Gln
 865                 870                 875                 880

 gta atc cca ggc tca gtg tgt tta aaa tac aat gaa aaa ggt atg ccc     2688
 Val Ile Pro Gly Ser Val Cys Leu Lys Tyr Asn Glu Lys Gly Met Pro
                 885                 890                 895

 aca ggt gaa gcc atg gtg gcc ttt gag tct cgg gat gaa gcc aca gct     2736
 Thr Gly Glu Ala Met Val Ala Phe Glu Ser Arg Asp Glu Ala Thr Ala
             900                 905                 910

 gct gtc att gac tta aat gac agg cct ata ggt tca aga aaa gta aaa     2784
 Ala Val Ile Asp Leu Asn Asp Arg Pro Ile Gly Ser Arg Lys Val Lys
         915                 920                 925

 ctt gta tta ggg tag ccattcacat cattttttat agggtagatc ttcatattgc     2839
 Leu Val Leu Gly 
     930

 tgtgattaat gcatccagat tgttttccta gtatttccag gttagaacct gtggattgtt   2899

 tcaattgcat atagcttggt ttccataaca tagagcattg gttgactgtt tacagaagac   2959

 tcactcacca ggataaacat tgctgtatgt tacagtaaag ctatctggag agaacacata   3019

 aatgattttg gcataccatt agagaaacca tttgtaaaac tcaaatgacc acataaagct   3079

 tatcaaggag tctagattgg ttttgtttta taccatatgg gatgaagaaa atagaaatgt   3139

 cagtagaact cattgagggt gctcttgcca gctgctgaaa atagaagttg gctactctca   3199

 gaatttggtt taaagctgga cagatttgct ttgttatagg gtaaagcttt gtctaaagtc   3259

 ctcattttct tttaaaattg aataaaattt ctgtatacag attcattgta tgtaccttta   3319

 ttgcttctta agggtccttg ctgtatagac agtcctgctt cagaagttgc tgctttgttt   3379

 gtctaattga ctcatttgta aatgagcaga actgttttgt tggttttttt ccctaaatat   3439

 aaaagtccac acttcgtttg tgctataacc tcaaactttg atttctaatg tcacacttaa   3499

 aactgtgtgg aataagactt ttgccataaa aataaactat ggagtccttt atctaccaga   3559

 gcctttttgg tttgaccgcc acgatttagg ttagtcagtt taaaaattgt tcatgttgtt   3619

 tggatggtat cgaaaaccag aaaccacttt taataatgtg tttaagatac ttgatttgaa   3679

 gtccttttca tatggactaa ttgtagtatc aatttcctcc tgtcccgatt atgtgaaatt   3739

 ttggccttta aacaaagagg ggcccattca taagaaagtg ttatatctag gtttttaaaa   3799

 ctgaagttga aattatcttt gttagcagta gtagtataga ataaaagatc cgtatgctgg   3859

 ttcgtagatt gatacgtgtt agtcctgtta tttggaggct ttttggcata gttgttcgat   3919

 caggagcctg tttactaaaa gtcttcatac agagtacaag tgcagccgtc cagaggagaa   3979

 aattgagatt cttgaccctt tcatactctt ttctttggta ttcaggacac taaggcagga   4039

 ggaccacatg agttctggtt ggtaagtgtc cttgtcatga aaacacttgc cttacaaggc   4099

 tctaattatg atttccctag tcagtgctct gaagatgtgt cacattatat tataaacaat   4159

 acggaagggg agataggtga gatgatatga aaaacaaatt ttctcactgt cataaaaggc   4219

 tctaattatg gttactttcc ttgtgatgaa aaacttggcc ttacagggct ctagttatgg   4279

 ttactttccc tagtcaatgc tctgaaaatg tgtcacatta taaacaatac agaaggagag   4339

 atagatgaga gatcatgaaa accaaatttt atcttttaca tggccccttt gtcttcgttt   4399

 gaaacatccc caacatttcc tacaaatcag cgtagttaca aaggggtcag tcttttaaaa   4459

 taagtatttc ctattaaact atatatatat acagtgcctt tttggtgttg tgagtcagtg   4519

 gaacactgaa atacagcggt tgtgtaattt aagagtggca acagtttcat ttgataagat   4579

 ttgaaaaggc tttttatcac tacaatctta gaggattgac agtacaggat ttttgtttaa   4639

 gagaaggatt gtttagactc aagaggtgac tatgttgtgg gtcttttgat aattcatgaa   4699

 tacagatttg ctttgaccga tcactagata ctgcctcctc aatttcaaaa gcaatataac   4759

 gtttgtatat gctgtttaat ttaagttaat gttaagtaat catttctcat tccaaagaca   4819

 atgcaaaaaa cttcagcact gcttgagagt tgtatttcag ccacagatat tttctccatt   4879

 ggaaagctat tttcatttta gaaaaatggg ttgtttgaag atgaaagtct tttatctttt   4939

 ttcacaattt attttggtta tatgttcgta cattcttatt aaatatttca tacactttat   4999

 tgcaactact ttgttatttc tacatcttag ataaatgctg aaaaggaaaa cgatttcatt   5059

 gttcatctaa ttaaataaat taaaagagcg gtttgtgtag aaattggaga gaactatgtt   5119

 ttatatgaat cacaacagtg ctcgttgtgg actgtaatta aatgctttgc cctctggaac   5179

 ttgatttttg tgtatctgag atttattaac agtgctaact gctaaggata ctgtttatct   5239

 tgttctgggc attggagttt cagtttttaa aaaattcttg aaaatgtatt ctgtgaaact   5299

 actcatacct ctcttcctgc gaattttctc ctaagaacta ggtttggggt agaaatgaat   5359

 tgacattatt ttctcatttg ctttgtatgg tatgaaggat ttgtaaagct ttgctcaaag   5419

 ttgtgtgcat ttgtaaacac tatcatgata ttttcaattt tatgtgtaaa ttttattgtc   5479

 tgtttttggt gactctgaca ttaatggaag agaatatttt ccattagatt taattttttt   5539

 tcctctcaaa aaaaaaaaaa                                               5559




      <210> 133
      <211> 4058
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (454)..(2523)

      <400> 133
 ggggctcgtc aatatccagg gattcccttg cccgagaccc ttgaccgtgc ttcctgggtc     60

 ctacgccgca acgtcctctg gcagctcgaa gaagctgtcg gggcttgcag gagagcgggc    120

 aaactgaagc ctgaaacatg gggactcgag gaacatccgg gtggaatcgc agactcaccg    180

 gagcgcagcg cctgggccag ggcctgggac cctcgtccgc cccgcgctcc cctgcacccc    240

 ttccccacgc tgctcccctc ttcctaagcg gccccccctc tcccgggcag cagaagaagg    300

 ggtgggaccc gggcgggctc cgggaggggg ccctggagga atggatggtg gcggaagggc    360

 ggagcagggg cggggcccgc ggagactcca cggggcgccc cgggcgtgag gcacccactc    420

 tgggagcaca gagagctcag gtagcctgcc tag atg gcg gcg cgc acc ctg ggc     474
                                      Met Ala Ala Arg Thr Leu Gly
                                        1               5

 cgc ggc gtc ggg agg ctg ctg ggc agc ctg cga ggg ctc tcg ggg cag      522
 Arg Gly Val Gly Arg Leu Leu Gly Ser Leu Arg Gly Leu Ser Gly Gln
          10                  15                  20

 ccc gcg cgg ccg ccg tgc ggg gtg agc gcg ccg cgc agg gcg gcc tcg      570
 Pro Ala Arg Pro Pro Cys Gly Val Ser Ala Pro Arg Arg Ala Ala Ser
      25                  30                  35

 gga ccc tcg ggc agc gct ccc gca gtt gca gca gca gca gca cag cca      618
 Gly Pro Ser Gly Ser Ala Pro Ala Val Ala Ala Ala Ala Ala Gln Pro
  40                  45                  50                  55

 ggc tcg tat ccc gcg ctg agt gca cag gca gcc cgg gag ccg gcc gcc      666
 Gly Ser Tyr Pro Ala Leu Ser Ala Gln Ala Ala Arg Glu Pro Ala Ala
                  60                  65                  70

 ttc tgg ggg cct ctg gcg cgg gac act ctc gtg tgg gac acc ccc tac      714
 Phe Trp Gly Pro Leu Ala Arg Asp Thr Leu Val Trp Asp Thr Pro Tyr
              75                  80                  85

 cac acc gtc tgg gac tgc gac ttc agc act ggc aag atc ggc tgg ttc      762
 His Thr Val Trp Asp Cys Asp Phe Ser Thr Gly Lys Ile Gly Trp Phe
          90                  95                 100

 ctg gga ggc cag tta aat gtc tct gtc aac tgc ttg gac cag cat gtt      810
 Leu Gly Gly Gln Leu Asn Val Ser Val Asn Cys Leu Asp Gln His Val
     105                 110                 115

 cgg aag tcc ccc gag agc gtt gct ttg atc tgg gag cgc gat gag cct      858
 Arg Lys Ser Pro Glu Ser Val Ala Leu Ile Trp Glu Arg Asp Glu Pro
 120                 125                 130                 135

 gga acg gaa gtg agg atc acc tac agg gaa cta ctg gag acc acg tgc      906
 Gly Thr Glu Val Arg Ile Thr Tyr Arg Glu Leu Leu Glu Thr Thr Cys
                 140                 145                 150

 cgc ctg gcc aac acg ctg aag agg cat gga gtc cac cgt ggg gac cgt      954
 Arg Leu Ala Asn Thr Leu Lys Arg His Gly Val His Arg Gly Asp Arg
             155                 160                 165

 gtt gcc atc tac atg ccc gtg tcc cca ttg gct gtg gca gca atg ctg     1002
 Val Ala Ile Tyr Met Pro Val Ser Pro Leu Ala Val Ala Ala Met Leu
         170                 175                 180

 gcc tgt gcc agg atc gga gct gtc cac aca gtc atc ttt gct ggc ttc     1050
 Ala Cys Ala Arg Ile Gly Ala Val His Thr Val Ile Phe Ala Gly Phe
     185                 190                 195

 agt gca gag tcc ttg gct ggg agg atc aat gat gcc aag tgc aag gtg     1098
 Ser Ala Glu Ser Leu Ala Gly Arg Ile Asn Asp Ala Lys Cys Lys Val
 200                 205                 210                 215

 gtt atc acc ttc aac caa gga ctc cgg ggt ggg cgc gtg gtg gag ctg     1146
 Val Ile Thr Phe Asn Gln Gly Leu Arg Gly Gly Arg Val Val Glu Leu
                 220                 225                 230

 aag aaa ata gtg gat gag gct gtg aag cac tgc ccc acc gtg cag cat     1194
 Lys Lys Ile Val Asp Glu Ala Val Lys His Cys Pro Thr Val Gln His
             235                 240                 245

 gtc ctg gtg gct cac agg aca gac aac aag gtc cac atg ggg gat ctg     1242
 Val Leu Val Ala His Arg Thr Asp Asn Lys Val His Met Gly Asp Leu
         250                 255                 260

 gac gtc ccg ctg gag cag gaa atg gcc aag gag gac cct gtt tgc gcc     1290
 Asp Val Pro Leu Glu Gln Glu Met Ala Lys Glu Asp Pro Val Cys Ala
     265                 270                 275

 cca gag agc atg ggc agt gag gac atg ctc ttc atg ctg tac acc tca     1338
 Pro Glu Ser Met Gly Ser Glu Asp Met Leu Phe Met Leu Tyr Thr Ser
 280                 285                 290                 295

 ggg agc acc gga atg ccc aag ggc atc gtc cat acc cag gca ggc tac     1386
 Gly Ser Thr Gly Met Pro Lys Gly Ile Val His Thr Gln Ala Gly Tyr
                 300                 305                 310

 ctg ctc tat gcc gcc ctg act cac aag ctt gtg ttt gac cac cag cca     1434
 Leu Leu Tyr Ala Ala Leu Thr His Lys Leu Val Phe Asp His Gln Pro
             315                 320                 325

 ggt gac atc ttt ggc tgt gtg gcc gac atc ggt tgg att aca gga cac     1482
 Gly Asp Ile Phe Gly Cys Val Ala Asp Ile Gly Trp Ile Thr Gly His
         330                 335                 340

 agc tac gtg gtg tat ggg cct ctc tgc aat ggt gcc acc agc gtc ctt     1530
 Ser Tyr Val Val Tyr Gly Pro Leu Cys Asn Gly Ala Thr Ser Val Leu
     345                 350                 355

 ttt gag agc acc cca gtt tat ccc aat gct ggt cgg tac tgg gag aca     1578
 Phe Glu Ser Thr Pro Val Tyr Pro Asn Ala Gly Arg Tyr Trp Glu Thr
 360                 365                 370                 375

 gta gag agg ttg aag atc aat cag ttc tat ggc gcc cca acg gct gtc     1626
 Val Glu Arg Leu Lys Ile Asn Gln Phe Tyr Gly Ala Pro Thr Ala Val
                 380                 385                 390

 cgg ctg ttg ctg aaa tac ggt gat gcc tgg gtg aag aag tat gat cgc     1674
 Arg Leu Leu Leu Lys Tyr Gly Asp Ala Trp Val Lys Lys Tyr Asp Arg
             395                 400                 405

 tcc tcc ctg cgg acc ctg ggg tca gtg gga gag ccc atc aac tgt gag     1722
 Ser Ser Leu Arg Thr Leu Gly Ser Val Gly Glu Pro Ile Asn Cys Glu
         410                 415                 420

 gcc tgg gag tgg ctt cac agg gtg gtg ggg gac agc agg tgc acg ctg     1770
 Ala Trp Glu Trp Leu His Arg Val Val Gly Asp Ser Arg Cys Thr Leu
     425                 430                 435

 gtg gac acc tgg tgg cag aca gaa aca ggt ggc atc tgc atc gca cca     1818
 Val Asp Thr Trp Trp Gln Thr Glu Thr Gly Gly Ile Cys Ile Ala Pro
 440                 445                 450                 455

 cgg ccc tcg gaa gaa ggg gcg gaa atc ctc cct gcc atg gcg atg agg     1866
 Arg Pro Ser Glu Glu Gly Ala Glu Ile Leu Pro Ala Met Ala Met Arg
                 460                 465                 470

 ccc ttc ttt ggc atc gtc ccc gtc ctc atg gat gag aag ggc agc gtc     1914
 Pro Phe Phe Gly Ile Val Pro Val Leu Met Asp Glu Lys Gly Ser Val
             475                 480                 485

 gtg gag ggc agc aac gtc tcc ggg gcc ctg tgc atc tcc cag gcc tgg     1962
 Val Glu Gly Ser Asn Val Ser Gly Ala Leu Cys Ile Ser Gln Ala Trp
         490                 495                 500

 ccg ggc atg gcc agg acc atc tat ggc gac cac cag cga ttt gtg gac     2010
 Pro Gly Met Ala Arg Thr Ile Tyr Gly Asp His Gln Arg Phe Val Asp
     505                 510                 515

 gcc tac ttc aag gcc tac cca ggc tat tac ttc act gga gac ggg gct     2058
 Ala Tyr Phe Lys Ala Tyr Pro Gly Tyr Tyr Phe Thr Gly Asp Gly Ala
 520                 525                 530                 535

 tac cga act gag ggc ggc tat tac cag atc aca ggg cgg atg gat gat     2106
 Tyr Arg Thr Glu Gly Gly Tyr Tyr Gln Ile Thr Gly Arg Met Asp Asp
                 540                 545                 550

 gtc atc aac atc agt ggc cac cgg ctg ggg acc gca gag att gag gac     2154
 Val Ile Asn Ile Ser Gly His Arg Leu Gly Thr Ala Glu Ile Glu Asp
             555                 560                 565

 gcc atc gcc gac cac cct gca gta cca gaa agt gct gtc att ggc tac     2202
 Ala Ile Ala Asp His Pro Ala Val Pro Glu Ser Ala Val Ile Gly Tyr
         570                 575                 580

 ccc cac gac atc aaa gga gaa gct gcc ttt gcc ttc att gtg gtg aaa     2250
 Pro His Asp Ile Lys Gly Glu Ala Ala Phe Ala Phe Ile Val Val Lys
     585                 590                 595

 gat agt gcg ggt gac tca gat gtg gtg gtg cag gag ctc aag tcc atg     2298
 Asp Ser Ala Gly Asp Ser Asp Val Val Val Gln Glu Leu Lys Ser Met
 600                 605                 610                 615

 gtg gcc acc aag atc gcc aaa tat gct gtg cct gat gag atc ctg gtg     2346
 Val Ala Thr Lys Ile Ala Lys Tyr Ala Val Pro Asp Glu Ile Leu Val
                 620                 625                 630

 gtg aaa cgt ctt cca aaa acc agg tct ggg aag gtc atg cgg cgg ctc     2394
 Val Lys Arg Leu Pro Lys Thr Arg Ser Gly Lys Val Met Arg Arg Leu
             635                 640                 645

 ctg agg aag atc atc act agt gag gcc cag gag ctg gga gac act acc     2442
 Leu Arg Lys Ile Ile Thr Ser Glu Ala Gln Glu Leu Gly Asp Thr Thr
         650                 655                 660

 acc ttg gag gac ccc agc atc atc gca gag atc ctg agt gtc tac cag     2490
 Thr Leu Glu Asp Pro Ser Ile Ile Ala Glu Ile Leu Ser Val Tyr Gln
     665                 670                 675

 aag tgc aag gac aag cag gct gct gct aag tga gctggcac cttgtggggc     2541
 Lys Cys Lys Asp Lys Gln Ala Ala Ala Lys 
 680                 685

 tcttgggatg ggcgggcacc caagccctgg cttgtccttc ccagaaggta cccctgaggt   2601

 tggcgtcttc ctacgtccca gaagcagccc ccaccccaca catgacccac accgccctca   2661

 cgtgaagctg ggctgagagc cctttctccc atccattgga ggtcccagga gtgtcaccca   2721

 tggagaggct atgcgacatg gctagggctg gttctgccat ctgagtttgg tttcctggaa   2781

 tgaaaaggca ttgccatctc cattcctctg ccctcttgag ccagcacagg aaggtgaggc   2841

 cctgggatag cgcgcctgct cagataacac agagctagtt agctagtagc aaccgtgttt   2901

 tctccagatc tgtctagata caaaggtcag aaatcttatt tttatacttt tatattgtgg   2961

 aagaacagca tgcaacactc acatgtagtg tgtggattta cttgaacatg ttctttttaa   3021

 catgtagtta tgaaaatctc cttttttgcc tctactggtg aggaaacatg aggatcagag   3081

 gccacatttt taattattgt tagtgtattt ggaagtctga attggagatg tttgtacctc   3141

 tgtctaaaca gttcccttga gaacttccaa gcctccggca tcttttcctg gtgagtgttt   3201

 ctcctgtgct tggttgtgta taatggagct aactcctaag cggtggggtg aatgtggccg   3261

 ccttagttct gaagctactc cagttatgtt ctgtttcttc aagctgtgat ccagaaagat   3321

 ttttgtgccc ccagatgcct cttgatagga gaggcaacat actccaaata gttgggttct   3381

 tcagggaagc tattagaaac tcaggtgact tgttagagca ctaacttggt cagagccaaa   3441

 tcctggcaaa cgctgcctga ccttcactct gtggttgggg cagtgagaac cactgaggtc   3501

 caatgatgag acttggaggt ctggatccag tctctctttg ttttaatgtg acttaggtgc   3561

 tgtcaacatt agcaagataa tggaaatcac gacgccagtg ggtgcttacc tccctgctag   3621

 gcatgcaggg gctggcggtt ggcaggggaa ggaggcccag tgagccgggt cccttagggg   3681

 agggagagtt tgtcctcttt gccccacagt ctacccttca gggccttgtg gcagtgccag   3741

 tgttcggggg gtgtctgggc cactgagtac ccactcggtc gtggttgtgc tggcctcttg   3801

 ggtgagtgaa cctgtgaagc ccaggaggtg gtgttggctg cagggtacac aaatactgag   3861

 tggtggtctt ttgttacagg cttagcaaca aagctgtgcc ctgggcatgg ggggctgtag   3921

 tgtagctaca gttgtgcgtt tgtgaaatgg cttagctttc catgttgctg agaggaacct   3981

 ggacatggtc ccgggcatct gaatgatctg taggggaggg agttcaaata aagctttatt   4041

 ttgttcaaaa aaaaaaa                                                  4058




      <210> 134
      <211> 1227
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(659)

      <400> 134
 atccccag atg cga aaa gcc cag tgg gcc agg cga gca gcg gcg cgc aga      50
          Met Arg Lys Ala Gln Trp Ala Arg Arg Ala Ala Ala Arg Arg
            1               5                  10

 agt ccc tgc ccc gcg gcc cgg ccc cgg ccc cgc cct act gag ggt gcg       98
 Ser Pro Cys Pro Ala Ala Arg Pro Arg Pro Arg Pro Thr Glu Gly Ala
  15                  20                  25                  30

 cag acg gca ccc gcc ttt tac gac gcg ccg gaa agc aac ggc aag ggc      146
 Gln Thr Ala Pro Ala Phe Tyr Asp Ala Pro Glu Ser Asn Gly Lys Gly
                  35                  40                  45

 cgc agc cag cac cgg gcg gag agg gct acc atg ggg aaa atc gcg ctg      194
 Arg Ser Gln His Arg Ala Glu Arg Ala Thr Met Gly Lys Ile Ala Leu
              50                  55                  60

 caa ctc aaa gcc acg ctg gag aac atc acc aac ctc cgg ccc gtg ggc      242
 Gln Leu Lys Ala Thr Leu Glu Asn Ile Thr Asn Leu Arg Pro Val Gly
          65                  70                  75

 gag gac ttc cgg tgg tac ctg aag atg aaa tgt ggc aac tgt ggt gag      290
 Glu Asp Phe Arg Trp Tyr Leu Lys Met Lys Cys Gly Asn Cys Gly Glu
      80                  85                  90

 att tcg gac aag tgg cag tac atc cgg ctg atg gac agt gtg gca ctg      338
 Ile Ser Asp Lys Trp Gln Tyr Ile Arg Leu Met Asp Ser Val Ala Leu
  95                 100                 105                 110

 aag ggg ggc cgt ggc agt gct tcc atg gtc cag aag tgc aag ctg tgt      386
 Lys Gly Gly Arg Gly Ser Ala Ser Met Val Gln Lys Cys Lys Leu Cys
                 115                 120                 125

 gca aga gaa aat tcc atc gag att tta agc agc acc atc aag cct tac      434
 Ala Arg Glu Asn Ser Ile Glu Ile Leu Ser Ser Thr Ile Lys Pro Tyr
             130                 135                 140

 aat gct gaa gac aat gag aac ttc aag aca ata gtg gag ttt gag tgc      482
 Asn Ala Glu Asp Asn Glu Asn Phe Lys Thr Ile Val Glu Phe Glu Cys
         145                 150                 155

 cgg ggc ctt gaa cca gtt gat ttc cag ccg cag gct ggg ttt gct gct      530
 Arg Gly Leu Glu Pro Val Asp Phe Gln Pro Gln Ala Gly Phe Ala Ala
     160                 165                 170

 gaa ggt gtg gag tca ggg aca gcc ttc agt gac att aat ctg cag gag      578
 Glu Gly Val Glu Ser Gly Thr Ala Phe Ser Asp Ile Asn Leu Gln Glu
 175                 180                 185                 190

 aag gac tgg act gac tat gat gaa aag gcc cag gag tct gtg gga atc      626
 Lys Asp Trp Thr Asp Tyr Asp Glu Lys Ala Gln Glu Ser Val Gly Ile
                 195                 200                 205

 tat gag gtc acc cac cag ttt gtg aag tgc tga tccctctt ccttcccagt      677
 Tyr Glu Val Thr His Gln Phe Val Lys Cys 
             210                 215

 tgcccttaag aactgagaaa ggacaaagta ctctaagcag cagagcccac agaggctcgt    737

 tcctttgacc cttgtctcct ggtggctata cgaaaccttc acaatctgca tgctggactt    797

 tattacagct tcccaagccc catcaataaa gcccctgttc acgctgcact ggtgcatgaa    857

 ggtgaagtaa ggaggcagct actccctcca caaataagaa ttcgtgcagc agcagttcac    917

 tccttaggaa aatgaagagt atttttaagg agatggtatc tccccagtca agggcaagtt    977

 tacagagatg aaaccgcgat cccaccatca ctcaatgagc cagaagccaa tggtgacgta   1037

 ctgttacctg aacttactga acttgctgtt ggaaagatct ttgtgaggat taggaattag   1097

 gttaaaagaa attaagaacc atcttcaagc aaaaattaaa ctttatttct gcttaaacaa   1157

 taaatacacc tgagttagtt ttccaaacct ttcctcctga ttaaatgccc ttaaaactta   1217

 aaaaaaaaaa                                                          1227




      <210> 135
      <211> 1275
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(1225)

      <400> 135
 aaggatcctt aattaaatta atcccccccc cccccccggt gggaccgctg accgcgcggc     60

 tgctccgctc tccccgctcc aagcgccgat ctgggcaccc gccaccagc    atg gac     115
                                                          Met Asp
                                                            1

 gct cgc cgc gtg ccg cag aaa gat ctc aga gta aag aag aac tta aag      163
 Ala Arg Arg Val Pro Gln Lys Asp Leu Arg Val Lys Lys Asn Leu Lys
           5                  10                  15

 aaa ttc aga tat gtg aag ttg att tcc atg gaa acc tcg tca tcc tct      211
 Lys Phe Arg Tyr Val Lys Leu Ile Ser Met Glu Thr Ser Ser Ser Ser
      20                  25                  30

 gat gac agt tgt gac agc ttt gct tct gat aat ttt gca aac acg agg      259
 Asp Asp Ser Cys Asp Ser Phe Ala Ser Asp Asn Phe Ala Asn Thr Arg
  35                  40                  45                  50

 ctg cag tca gtt cgg gaa ggc tgt agg acc cgc agc cag tgc agg cac      307
 Leu Gln Ser Val Arg Glu Gly Cys Arg Thr Arg Ser Gln Cys Arg His
                  55                  60                  65

 tct gga cct ctc agg gtg gcg atg aag ttt cca gcg cgg agt acc agg      355
 Ser Gly Pro Leu Arg Val Ala Met Lys Phe Pro Ala Arg Ser Thr Arg
              70                  75                  80

 gga gca acc aac aaa aaa gca gag tcc cgc cag ccc tca gag aat tct      403
 Gly Ala Thr Asn Lys Lys Ala Glu Ser Arg Gln Pro Ser Glu Asn Ser
          85                  90                  95

 gtg act gat tcc aac tcc gat tca gaa gat gaa agt gga atg aat ttt      451
 Val Thr Asp Ser Asn Ser Asp Ser Glu Asp Glu Ser Gly Met Asn Phe
     100                 105                 110

 ttg gag aaa agg gct tta aat ata aag caa aac aaa gca atg ctt gca      499
 Leu Glu Lys Arg Ala Leu Asn Ile Lys Gln Asn Lys Ala Met Leu Ala
 115                 120                 125                 130

 aaa ctc atg tct gaa tta gaa agc ttc cct ggc tcg ttc cgt gga aga      547
 Lys Leu Met Ser Glu Leu Glu Ser Phe Pro Gly Ser Phe Arg Gly Arg
                 135                 140                 145

 cat ccc ctc cca ggc tcc gac tca caa tca agg aga ccg cga agg cgt      595
 His Pro Leu Pro Gly Ser Asp Ser Gln Ser Arg Arg Pro Arg Arg Arg
             150                 155                 160

 aca ttc ccg ggt gtt gct tcc agg aga aac cct gaa cgg aga gct cgt      643
 Thr Phe Pro Gly Val Ala Ser Arg Arg Asn Pro Glu Arg Arg Ala Arg
         165                 170                 175

 cct ctt acc agg tca agg tcc cgg atc ctc ggg tcc ctt gac gct cta      691
 Pro Leu Thr Arg Ser Arg Ser Arg Ile Leu Gly Ser Leu Asp Ala Leu
     180                 185                 190

 ccc atg gag gag gag gag gaa gag gat aag tac atg ttg gtg aga aag      739
 Pro Met Glu Glu Glu Glu Glu Glu Asp Lys Tyr Met Leu Val Arg Lys
 195                 200                 205                 210

 agg aag acc gtg gat ggc tac atg aat gaa gat gac ctg ccc aga agc      787
 Arg Lys Thr Val Asp Gly Tyr Met Asn Glu Asp Asp Leu Pro Arg Ser
                 215                 220                 225

 cgt cgc tcc aga tca tcc gtg acc ctt ccg cat ata att cgc cca gtg      835
 Arg Arg Ser Arg Ser Ser Val Thr Leu Pro His Ile Ile Arg Pro Val
             230                 235                 240

 gaa gaa att aca gag gag gag ttg gag aac gtc tgc agc aat tct cga      883
 Glu Glu Ile Thr Glu Glu Glu Leu Glu Asn Val Cys Ser Asn Ser Arg
         245                 250                 255

 gag aag ata tat aac cgt tca ctg ggc tct act tgt cat caa tgc cgt      931
 Glu Lys Ile Tyr Asn Arg Ser Leu Gly Ser Thr Cys His Gln Cys Arg
     260                 265                 270

 cag aag act att gat acc aaa aca aac tgc aga aac cca gac tgc tgg      979
 Gln Lys Thr Ile Asp Thr Lys Thr Asn Cys Arg Asn Pro Asp Cys Trp
 275                 280                 285                 290

 ggc gtt cga ggc cag ttc tgt ggc ccc tgc ctt cga aac cgt tat ggt     1027
 Gly Val Arg Gly Gln Phe Cys Gly Pro Cys Leu Arg Asn Arg Tyr Gly
                 295                 300                 305

 gaa gag gtc agg gat gct ctg ctg gat ccg aac tgg cat tgc ccg cct     1075
 Glu Glu Val Arg Asp Ala Leu Leu Asp Pro Asn Trp His Cys Pro Pro
             310                 315                 320

 tgt cga gga atc tgc aac tgc agt ttc tgc cgg cag cga gat gga cgg     1123
 Cys Arg Gly Ile Cys Asn Cys Ser Phe Cys Arg Gln Arg Asp Gly Arg
         325                 330                 335

 tgt gcg act ggg gtc ctt gtg tat tta gcc aaa tat cat ggc ttt ggg     1171
 Cys Ala Thr Gly Val Leu Val Tyr Leu Ala Lys Tyr His Gly Phe Gly
     340                 345                 350

 aat gtg cat gcc tac ttg aaa agc ctg aaa cag gaa ttt gaa atg caa     1219
 Asn Val His Ala Tyr Leu Lys Ser Leu Lys Gln Glu Phe Glu Met Gln
 355                 360                 365                 370

 gca taa tatctggaaa atttgctgcc tgccttctac ttctcaaatc tttcttgtaa      1275
 Ala 






      <210> 136
      <211> 3382
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (425)..(2464)

      <400> 136
 tgccgcaatc ctggtggacc cggtgccgtg gcccaggggc cgggccgagg tcccgggggc     60

 ggtgccttgc gggcccgtcc cggggcggtg cctggtgggc tggccccgcg gttcctcccc    120

 tctctgcggg cccagtcgcc ctttggccgg gcgagctaat cgtcggctca atgacgacga    180

 ggcccgaccc ttcccgtcca ggacctacag agacaaccga aggagagccc aaggcggctt    240

 ctttgctgtc gccgccccca ctgaagcaag agctccccgg ctccactgaa acaccagctc    300

 atttaagctt tccccaacga ccggccctcc gggacgatac ctaacaacga ccggcgcccg    360

 catctggaat aggctggcga gatacttagt atccgagggc tcgggacttg gcgccatcga    420

 ggtc atg ggg acc cag gat cca ggg aac atg gga acc ggc gtc cca gcc     469
      Met Gly Thr Gln Asp Pro Gly Asn Met Gly Thr Gly Val Pro Ala
        1               5                  10                  15

 tcg gag cag ata agc tgt gcc aaa gag gat cca caa gtt tat tgc cct      517
 Ser Glu Gln Ile Ser Cys Ala Lys Glu Asp Pro Gln Val Tyr Cys Pro
                  20                  25                  30

 gaa gag act ggc ggc acc aag gat gtg cag gtt aca gac tgt aag agt      565
 Glu Glu Thr Gly Gly Thr Lys Asp Val Gln Val Thr Asp Cys Lys Ser
              35                  40                  45

 ccc gaa gac agc cga ccc cca aaa gag acg gac tgc tgc aat ccg gag      613
 Pro Glu Asp Ser Arg Pro Pro Lys Glu Thr Asp Cys Cys Asn Pro Glu
          50                  55                  60

 gac tct ggg cag ctg atg gtt tcc tat gag ggt aaa gct atg ggc tac      661
 Asp Ser Gly Gln Leu Met Val Ser Tyr Glu Gly Lys Ala Met Gly Tyr
      65                  70                  75

 cag gtg cct ccc ttt ggc tgg cgc atc tgt ctg gct cat gag ttt aca      709
 Gln Val Pro Pro Phe Gly Trp Arg Ile Cys Leu Ala His Glu Phe Thr
  80                  85                  90                  95

 gag aag agg aaa ccc ttt caa gct aac aac gtc tcc cta agc aac atg      757
 Glu Lys Arg Lys Pro Phe Gln Ala Asn Asn Val Ser Leu Ser Asn Met
                 100                 105                 110

 ata aag cat ata ggc atg ggc ttg agg tac ctg cag tgg tgg tac cgg      805
 Ile Lys His Ile Gly Met Gly Leu Arg Tyr Leu Gln Trp Trp Tyr Arg
             115                 120                 125

 aag acc cat gtg gaa aag aag aca cct ttc atc gac atg atc aat tct      853
 Lys Thr His Val Glu Lys Lys Thr Pro Phe Ile Asp Met Ile Asn Ser
         130                 135                 140

 gta ccc cta aga cag att tat ggt tgt ccc ttg ggt ggc atc ggg gga      901
 Val Pro Leu Arg Gln Ile Tyr Gly Cys Pro Leu Gly Gly Ile Gly Gly
     145                 150                 155

 ggc act att acc cgt ggc tgg aga ggc cag ttc tgt cgt tgg cag ctt      949
 Gly Thr Ile Thr Arg Gly Trp Arg Gly Gln Phe Cys Arg Trp Gln Leu
 160                 165                 170                 175

 aac cct gga atg tat cag cac cgg aca gtc atc gct gac caa ttc aca      997
 Asn Pro Gly Met Tyr Gln His Arg Thr Val Ile Ala Asp Gln Phe Thr
                 180                 185                 190

 gtg tgc ctg cgt cgg gaa ggg cag act gtg tac cag caa gtc ctg tcc     1045
 Val Cys Leu Arg Arg Glu Gly Gln Thr Val Tyr Gln Gln Val Leu Ser
             195                 200                 205

 ctg gag cgc cca agt gtc ctc cgc agc tgg aac tgg ggc ctg tgt ggg     1093
 Leu Glu Arg Pro Ser Val Leu Arg Ser Trp Asn Trp Gly Leu Cys Gly
         210                 215                 220

 tac ttt gct ttc tac cat gcc ctc tat ccc cga gcc tgg act gtc tat     1141
 Tyr Phe Ala Phe Tyr His Ala Leu Tyr Pro Arg Ala Trp Thr Val Tyr
     225                 230                 235

 cag ctt cct ggc cag aat gtc acc ctc acc tgc cgt cag atc aca ccc     1189
 Gln Leu Pro Gly Gln Asn Val Thr Leu Thr Cys Arg Gln Ile Thr Pro
 240                 245                 250                 255

 atc ttg ccc cat gac tac cag gac agc agc ctg cct gta gga gtc ttt     1237
 Ile Leu Pro His Asp Tyr Gln Asp Ser Ser Leu Pro Val Gly Val Phe
                 260                 265                 270

 gtg tgg gat gtg gaa aat gaa ggg gac gaa gct cta gat gtg tcc atc     1285
 Val Trp Asp Val Glu Asn Glu Gly Asp Glu Ala Leu Asp Val Ser Ile
             275                 280                 285

 atg ttc tcc atg cgg aat gga ctg ggt ggt gga gac gat gcc cca ggg     1333
 Met Phe Ser Met Arg Asn Gly Leu Gly Gly Gly Asp Asp Ala Pro Gly
         290                 295                 300

 ggt ttg tgg aat gag ccc ttc tgt ctg gag cgt agc ggg gaa act gtc     1381
 Gly Leu Trp Asn Glu Pro Phe Cys Leu Glu Arg Ser Gly Glu Thr Val
     305                 310                 315

 cgg ggg ctg ctc ctg cat cat cca acc ctt cca aac ccc tac acg atg     1429
 Arg Gly Leu Leu Leu His His Pro Thr Leu Pro Asn Pro Tyr Thr Met
 320                 325                 330                 335

 gct gtg gct gca cga gtc acg gca gct acc acg gta acc cac atc aca     1477
 Ala Val Ala Ala Arg Val Thr Ala Ala Thr Thr Val Thr His Ile Thr
                 340                 345                 350

 gcc ttt gac cct gac agc acg ggg cag cag gtg tgg cag gat cta ctt     1525
 Ala Phe Asp Pro Asp Ser Thr Gly Gln Gln Val Trp Gln Asp Leu Leu
             355                 360                 365

 cag gat gga cag ctg gac tct ccc act ggc caa agc acc cct acg cag     1573
 Gln Asp Gly Gln Leu Asp Ser Pro Thr Gly Gln Ser Thr Pro Thr Gln
         370                 375                 380

 aaa gga gta ggc att gct gga gct gtg tgt gtt tcc agc aag ttg cga     1621
 Lys Gly Val Gly Ile Ala Gly Ala Val Cys Val Ser Ser Lys Leu Arg
     385                 390                 395

 cct cga ggc cag tgc cgc ctg gag ttt tca ctg gct tgg gac atg ccc     1669
 Pro Arg Gly Gln Cys Arg Leu Glu Phe Ser Leu Ala Trp Asp Met Pro
 400                 405                 410                 415

 agg atc atg ttt gga gct aaa ggc caa gtc cac tac agg cgg tat aca     1717
 Arg Ile Met Phe Gly Ala Lys Gly Gln Val His Tyr Arg Arg Tyr Thr
                 420                 425                 430

 agg ttc ttt ggc cag gat gga gat gca gca cct gcc ctc agc cac tat     1765
 Arg Phe Phe Gly Gln Asp Gly Asp Ala Ala Pro Ala Leu Ser His Tyr
             435                 440                 445

 gca ctg tgc cga tac gca gag tgg gaa gag agg atc tca gct tgg cag     1813
 Ala Leu Cys Arg Tyr Ala Glu Trp Glu Glu Arg Ile Ser Ala Trp Gln
         450                 455                 460

 agc ccg gta ttg gat gac aga tca ctg cct gcc tgg tac aaa tct gcg     1861
 Ser Pro Val Leu Asp Asp Arg Ser Leu Pro Ala Trp Tyr Lys Ser Ala
     465                 470                 475

 ctg ttc aat gaa cta tac ttc ctg gct gat gga ggc aca gtg tgg ctg     1909
 Leu Phe Asn Glu Leu Tyr Phe Leu Ala Asp Gly Gly Thr Val Trp Leu
 480                 485                 490                 495

 gaa gtt ctt gag gac tcc cta cca gag gag ctg ggc aga aac atg tgt     1957
 Glu Val Leu Glu Asp Ser Leu Pro Glu Glu Leu Gly Arg Asn Met Cys
                 500                 505                 510

 cac ctc cgc ccc acc cta cgg gac tac ggt cga ttt ggc tac ctt gag     2005
 His Leu Arg Pro Thr Leu Arg Asp Tyr Gly Arg Phe Gly Tyr Leu Glu
             515                 520                 525

 ggc cag gag tac cgc atg tac aac aca tat gat gtc cac ttt tat gct     2053
 Gly Gln Glu Tyr Arg Met Tyr Asn Thr Tyr Asp Val His Phe Tyr Ala
         530                 535                 540

 tcc ttt gcc ctc atc atg ctc tgg ccc aaa ctt gag ctc agc cta cag     2101
 Ser Phe Ala Leu Ile Met Leu Trp Pro Lys Leu Glu Leu Ser Leu Gln
     545                 550                 555

 tat gac atg gct ctg gcc act ctc agg gag gac ctg aca cgg cga cgg     2149
 Tyr Asp Met Ala Leu Ala Thr Leu Arg Glu Asp Leu Thr Arg Arg Arg
 560                 565                 570                 575

 tac ctg atg agt ggg gtg atg gca cct gtg aaa agg agg aac gtc atc     2197
 Tyr Leu Met Ser Gly Val Met Ala Pro Val Lys Arg Arg Asn Val Ile
                 580                 585                 590

 ccc cat gat att ggg gac cca gat gat gaa cca tgg ctc cgc gtc aat     2245
 Pro His Asp Ile Gly Asp Pro Asp Asp Glu Pro Trp Leu Arg Val Asn
             595                 600                 605

 gca tat tta atc cat gat act gct gat tgg aag gac ctg aac ctg aag     2293
 Ala Tyr Leu Ile His Asp Thr Ala Asp Trp Lys Asp Leu Asn Leu Lys
         610                 615                 620

 ttt gtg ctg cag gtt tat cgg gac tat tac ctc acg ggt gat caa aac     2341
 Phe Val Leu Gln Val Tyr Arg Asp Tyr Tyr Leu Thr Gly Asp Gln Asn
     625                 630                 635

 ttc ctg aag gac atg tgg cct gtg tgt cta gct gtg atg gaa tct gaa     2389
 Phe Leu Lys Asp Met Trp Pro Val Cys Leu Ala Val Met Glu Ser Glu
 640                 645                 650                 655

 atg aag ttg aca agg acc atg atg gac tca ttg aag atg gag gct atg     2437
 Met Lys Leu Thr Arg Thr Met Met Asp Ser Leu Lys Met Glu Ala Met
                 660                 665                 670

 cag acc aga cct atg atg gat ggg tga ccaca ggccccagtg cttactgtgg     2489
 Gln Thr Arg Pro Met Met Asp Gly 
             675

 agggctgtgg ctggcagctg tggctgtgat ggtccagatg gctgctctgt gtggggcaca   2549

 ggacatccag gataagtttt cttctatcct cagccggggc caagaagcct atgagagact   2609

 gctgtggaat ggccgctatt acaactatga cagcagctct cggcctcagt ctcgtagtgt   2669

 tatgtctgac cagtgtgctg gacagtggtt cctgaaggcc tgtggcctag gagaaggaga   2729

 cactgaggtg tttcctaccc aacatgtggt ccgtgctctc caaactatct ttgagctgaa   2789

 cgtccaggcc tttgcaggag gggccatggg ggctgtgaat gggatgcagc cccatggtgt   2849

 ccctgataaa tccagtgtgc agtctgatga agtctgggtg ggtgtggtct acgggctggc   2909

 agctaccatg atccaagagg gcctgacttg ggagggcttc cagacagctg aaggctgcta   2969

 ccgtaccgtg tgggagcgcc tgggtctggc cttccagacc ccagaggcat actgccagca   3029

 gcgagtgttc cgctcactgg cctacatgcg gccactgagc atatgggcca tgcagctagc   3089

 cctgcaacag cagcagcaca aaaaggcctc ctggccaaaa gtcaaacagg gcacaggact   3149

 aaggacaggg cctatgtttg gaccaaagga agccatggca aacctgagcc cagagtgagc   3209

 cgtctgaact gtgggaggga agtgctaaca gcccagcctc agcctggcct ttcttcttcc   3269

 ctcgtgaact cgtgcaacct gaccatcagg caatataccc ttcctttctc acccattgtc   3329

 cagtaatggg gtgaggtact agcacataga tatatatctt ctactgtcta tgg          3382




      <210> 137
      <211> 3881
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(2738)

      <400> 137
 tcccgggttt acgatttcgt gcccgctctc ggcgagcccg agccgtcgcc ggcccctcgg     60

 cggag    atg agc agg tcc gcg acg ctg ctg ctg tgc ctg ctg ggc tgc     107
          Met Ser Arg Ser Ala Thr Leu Leu Leu Cys Leu Leu Gly Cys
            1               5                  10

 cac gtc tgg aag gcg gtg acc aag acg ctg cgg gag ccc ggc gcc gga      155
 His Val Trp Lys Ala Val Thr Lys Thr Leu Arg Glu Pro Gly Ala Gly
  15                  20                  25                  30

 gcc caa gag gtg acg tta aag gtg cac atc agc gac gcc agc acc cac      203
 Ala Gln Glu Val Thr Leu Lys Val His Ile Ser Asp Ala Ser Thr His
                  35                  40                  45

 cag ccc gta gca gat gcg ctc atc gag atc ttc acc aac cag gcc tcc      251
 Gln Pro Val Ala Asp Ala Leu Ile Glu Ile Phe Thr Asn Gln Ala Ser
              50                  55                  60

 ata gcc tct ggc acc tcg ggg act gat ggc gtc gcc ttt atc aag ttc      299
 Ile Ala Ser Gly Thr Ser Gly Thr Asp Gly Val Ala Phe Ile Lys Phe
          65                  70                  75

 cag tat aag ctg ggc agt cag ttg att gtc acc gcc tcg aag cat gcc      347
 Gln Tyr Lys Leu Gly Ser Gln Leu Ile Val Thr Ala Ser Lys His Ala
      80                  85                  90

 tac gtg cca aac tct gcc cca tgg aag cca atc cgg tta cct gta ttt      395
 Tyr Val Pro Asn Ser Ala Pro Trp Lys Pro Ile Arg Leu Pro Val Phe
  95                 100                 105                 110

 tcc tct ctg agc ctt ggc ctg ctt cca gaa cgc tct gcc act cta atg      443
 Ser Ser Leu Ser Leu Gly Leu Leu Pro Glu Arg Ser Ala Thr Leu Met
                 115                 120                 125

 gta tat gaa gat gtc gtc caa ata gta tca gga ttc caa ggt gcc cgg      491
 Val Tyr Glu Asp Val Val Gln Ile Val Ser Gly Phe Gln Gly Ala Arg
             130                 135                 140

 cca cag cct cgc gtt cat ttc cag aga agg gct ctg agg ttg cct gag      539
 Pro Gln Pro Arg Val His Phe Gln Arg Arg Ala Leu Arg Leu Pro Glu
         145                 150                 155

 aac acc agc tac agt gac ctg acc gcg ttt ctc acg gcc gcc agc tcc      587
 Asn Thr Ser Tyr Ser Asp Leu Thr Ala Phe Leu Thr Ala Ala Ser Ser
     160                 165                 170

 cct tcg gag gtg gac agt ttt cct tat ttg cga gga tta gac gga aat      635
 Pro Ser Glu Val Asp Ser Phe Pro Tyr Leu Arg Gly Leu Asp Gly Asn
 175                 180                 185                 190

 gga aca gga aac agc acc agg cat gac ctg acc cca gtc aca gcc gtc      683
 Gly Thr Gly Asn Ser Thr Arg His Asp Leu Thr Pro Val Thr Ala Val
                 195                 200                 205

 agc gtc cac ttg ctg agc agt aat gga acg ccg gtg ctg gtg gat ggt      731
 Ser Val His Leu Leu Ser Ser Asn Gly Thr Pro Val Leu Val Asp Gly
             210                 215                 220

 ccc atc tat gtc act gtg ccc ctg gcc acg cag agc agc ctg agg cac      779
 Pro Ile Tyr Val Thr Val Pro Leu Ala Thr Gln Ser Ser Leu Arg His
         225                 230                 235

 aat gcc tat gtc gcg gcg tgg cgg ttt gac cag aag ctg gga acg tgg      827
 Asn Ala Tyr Val Ala Ala Trp Arg Phe Asp Gln Lys Leu Gly Thr Trp
     240                 245                 250

 ctg aag agc ggt ctg ggt ctt gtg cac cag gaa ggc agc cag ctg acg      875
 Leu Lys Ser Gly Leu Gly Leu Val His Gln Glu Gly Ser Gln Leu Thr
 255                 260                 265                 270

 tgg aca tac att gcc ccc cag ttg ggg tac tgg gtg gcc gcc atg tcc      923
 Trp Thr Tyr Ile Ala Pro Gln Leu Gly Tyr Trp Val Ala Ala Met Ser
                 275                 280                 285

 cct ccc atc cca ggt ccc gtt gta aca cag gac att acc acg tat cac      971
 Pro Pro Ile Pro Gly Pro Val Val Thr Gln Asp Ile Thr Thr Tyr His
             290                 295                 300

 acg gtg ttt ctt ttg gcc att tta gga gga atg gct ttc ata ctt ttg     1019
 Thr Val Phe Leu Leu Ala Ile Leu Gly Gly Met Ala Phe Ile Leu Leu
         305                 310                 315

 gtt ttg ctg tgt ctc ctt tta tat tat tgc agg agg aag tgc ttg aaa     1067
 Val Leu Leu Cys Leu Leu Leu Tyr Tyr Cys Arg Arg Lys Cys Leu Lys
     320                 325                 330

 cct cgt cag cac cac aga aaa ctg cag ctc cct gca gga ctg gag agt     1115
 Pro Arg Gln His His Arg Lys Leu Gln Leu Pro Ala Gly Leu Glu Ser
 335                 340                 345                 350

 tcc aaa aga gac cag tcc acg tcc atg tca cac att aac ttg ctg ttt     1163
 Ser Lys Arg Asp Gln Ser Thr Ser Met Ser His Ile Asn Leu Leu Phe
                 355                 360                 365

 tca cgc cga gcg tca gaa ttc cct ggc ccg ctg tcc gtc acc agc cac     1211
 Ser Arg Arg Ala Ser Glu Phe Pro Gly Pro Leu Ser Val Thr Ser His
             370                 375                 380

 ggc cgc ccc gag gcc ccc ggc acg aag gaa ctg atg agt gga gtc cat     1259
 Gly Arg Pro Glu Ala Pro Gly Thr Lys Glu Leu Met Ser Gly Val His
         385                 390                 395

 ttg gaa atg atg tct ccg ggc ggc gaa ggg gac ctg cac acc ccc atg     1307
 Leu Glu Met Met Ser Pro Gly Gly Glu Gly Asp Leu His Thr Pro Met
     400                 405                 410

 ctc aag ctc tcc tac agc acc tcc cag gaa ttt agc tcc cgg gag gag     1355
 Leu Lys Leu Ser Tyr Ser Thr Ser Gln Glu Phe Ser Ser Arg Glu Glu
 415                 420                 425                 430

 ctc ctc tct tgc aag gaa gag gat aaa agc cag atc tcc ttt gat aac     1403
 Leu Leu Ser Cys Lys Glu Glu Asp Lys Ser Gln Ile Ser Phe Asp Asn
                 435                 440                 445

 ctc act cca agt ggg acg ctg ggg aaa gac tac cat aag tca gtg gag     1451
 Leu Thr Pro Ser Gly Thr Leu Gly Lys Asp Tyr His Lys Ser Val Glu
             450                 455                 460

 gtt ttt ccc tta aag gca aga aaa tct atg gaa aga gaa ggc tac gag     1499
 Val Phe Pro Leu Lys Ala Arg Lys Ser Met Glu Arg Glu Gly Tyr Glu
         465                 470                 475

 tcc tcg ggc aat gat gac tac agg ggt agt tac aac acc gtg ctc tca     1547
 Ser Ser Gly Asn Asp Asp Tyr Arg Gly Ser Tyr Asn Thr Val Leu Ser
     480                 485                 490

 cag cct tta ttt gaa aag cag gac aga gaa ggt cca gcc tcc acg gga     1595
 Gln Pro Leu Phe Glu Lys Gln Asp Arg Glu Gly Pro Ala Ser Thr Gly
 495                 500                 505                 510

 agc aaa ctc acc att cag gaa cat ctg tac ccc gcg cct tca tca cct     1643
 Ser Lys Leu Thr Ile Gln Glu His Leu Tyr Pro Ala Pro Ser Ser Pro
                 515                 520                 525

 gag aaa gaa cag ctg ctg gac cgc aga ccc act gaa tgt atg atg tcg     1691
 Glu Lys Glu Gln Leu Leu Asp Arg Arg Pro Thr Glu Cys Met Met Ser
             530                 535                 540

 cga tca gta gat cac ctc gag aga cct acg tcc ttc cca cgg ccc ggc     1739
 Arg Ser Val Asp His Leu Glu Arg Pro Thr Ser Phe Pro Arg Pro Gly
         545                 550                 555

 cag tta atc tgc tgc agt tct gtc gac cag gtc aat gac agc gtt tac     1787
 Gln Leu Ile Cys Cys Ser Ser Val Asp Gln Val Asn Asp Ser Val Tyr
     560                 565                 570

 agg aaa gta ctg cct gcc ttg gtc atc ccg gct cat tat atg aaa ctc     1835
 Arg Lys Val Leu Pro Ala Leu Val Ile Pro Ala His Tyr Met Lys Leu
 575                 580                 585                 590

 ccc ggg gac cac tcc tat gtc agc cag ccc ctc gtc gtc ccg gct gat     1883
 Pro Gly Asp His Ser Tyr Val Ser Gln Pro Leu Val Val Pro Ala Asp
                 595                 600                 605

 cag cag ctt gag ata gaa aga cta cag gct gag ctg tcc aat ccc cat     1931
 Gln Gln Leu Glu Ile Glu Arg Leu Gln Ala Glu Leu Ser Asn Pro His
             610                 615                 620

 gcc ggg atc ttc cca cac ccg tcc tca cag atc cag ccc cag ccc ctg     1979
 Ala Gly Ile Phe Pro His Pro Ser Ser Gln Ile Gln Pro Gln Pro Leu
         625                 630                 635

 tct tcc cag gcc atc tct cag cag cac ctg cag gat gcg ggc acc cgg     2027
 Ser Ser Gln Ala Ile Ser Gln Gln His Leu Gln Asp Ala Gly Thr Arg
     640                 645                 650

 gag tgg agc cct cag aac gca tcc atg tcg gag tct ctc tcc atc cca     2075
 Glu Trp Ser Pro Gln Asn Ala Ser Met Ser Glu Ser Leu Ser Ile Pro
 655                 660                 665                 670

 gct tcc ctg aac gac gcg gct ttg gct cag atg aac agt gag gtg cag     2123
 Ala Ser Leu Asn Asp Ala Ala Leu Ala Gln Met Asn Ser Glu Val Gln
                 675                 680                 685

 ctc ctg act gaa aag gcc ctg atg gag ctt ggg ggt ggg aag ccg ctt     2171
 Leu Leu Thr Glu Lys Ala Leu Met Glu Leu Gly Gly Gly Lys Pro Leu
             690                 695                 700

 ccg cac ccc cgg gcg tgg ttc gtc tcc ttg gat ggc agg tcc aac gct     2219
 Pro His Pro Arg Ala Trp Phe Val Ser Leu Asp Gly Arg Ser Asn Ala
         705                 710                 715

 cac gtt aga cat tca tac att gat ctc caa aga gct gga agg aac gga     2267
 His Val Arg His Ser Tyr Ile Asp Leu Gln Arg Ala Gly Arg Asn Gly
     720                 725                 730

 agt aat gat gcc agt ttg gac tct ggc gta gat atg aat gaa cca aaa     2315
 Ser Asn Asp Ala Ser Leu Asp Ser Gly Val Asp Met Asn Glu Pro Lys
 735                 740                 745                 750

 tca gcc cgg aag gga agg gga gat gct ttg tct ctg cag cag aac tac     2363
 Ser Ala Arg Lys Gly Arg Gly Asp Ala Leu Ser Leu Gln Gln Asn Tyr
                 755                 760                 765

 ccg ccc gtc caa gag cac cag cag aaa gag cct cga gcc cca gac agc     2411
 Pro Pro Val Gln Glu His Gln Gln Lys Glu Pro Arg Ala Pro Asp Ser
             770                 775                 780

 acg gcc tac acg cag ctc gtg tac ctg gat gac gtg gaa cag agt ggt     2459
 Thr Ala Tyr Thr Gln Leu Val Tyr Leu Asp Asp Val Glu Gln Ser Gly
         785                 790                 795

 agc gaa tgt ggg acc acg gtc tgt acc ccc gag gac agt gcc ctg cga     2507
 Ser Glu Cys Gly Thr Thr Val Cys Thr Pro Glu Asp Ser Ala Leu Arg
     800                 805                 810

 tgc ttg ttg gag ggg tcg agt cgg aga agt ggt ggc cag ctg ccc agc     2555
 Cys Leu Leu Glu Gly Ser Ser Arg Arg Ser Gly Gly Gln Leu Pro Ser
 815                 820                 825                 830

 ctg cag gag gag acg acc aga cgg act gcg gat gcc ccc tcg gag cca     2603
 Leu Gln Glu Glu Thr Thr Arg Arg Thr Ala Asp Ala Pro Ser Glu Pro
                 835                 840                 845

 gca gcc agc ccc cac cag aga aga tct gcc cac gag gaa gag gaa gac     2651
 Ala Ala Ser Pro His Gln Arg Arg Ser Ala His Glu Glu Glu Glu Asp
             850                 855                 860

 gat gat gat gat gac caa gga gaa gac aag aaa agc ccc tgg cag aaa     2699
 Asp Asp Asp Asp Asp Gln Gly Glu Asp Lys Lys Ser Pro Trp Gln Lys
         865                 870                 875

 cgg gag gag agg ccc ctg atg gcg ttt aac att aaa tga gctatcgcag      2748
 Arg Glu Glu Arg Pro Leu Met Ala Phe Asn Ile Lys 
     880                 885                 890

 acccacctga ctgtggaata taaaattgcc aaatatcctt tctcatggaa gcgcgtaccc   2808

 gttcgtggag gaaacggaac ggcagcccag ccgtgggacg gacgtggacg tttactgcat   2868

 tcctgtttgc cgtgtaaatg ttagaaagga attaaagtta ttactcggaa taaaggatga   2928

 ctttggcgga tgtcgcccct gcaaggaggt ggctgaaagt ggtgtccaga tgtccttccg   2988

 aggactcggc gtatccgcca ccagggacat taagaaaccg cacgtgatgt cgctatgctc   3048

 taacgatcac ctcagttctc cctcggattc tgggaacaga tgaaactttt tgcatcgctt   3108

 gagtcatttt tatcacaata atcctactgt gaagctgtcg ttgagaactt aggttggcac   3168

 gtagcgtctc aaggtatgcg ttctctcaaa ggaaagctat gcatcgctgc ttcgttgtct   3228

 gattttgctt agattttgct ttggttaggt tgcgttttgg ggtttgcctt tttttgttgt   3288

 cgcttaaatg caatttggtt gtaaagattt gattcctttg tgttcatctg ttccgcttct   3348

 cagcggtcca tctcagcgtc tcccttcagg aaccgctgag tgtcctctct taacatccaa   3408

 gccttttaat gaaatcgtac tgaaatctgt atcagctaag agtcctccaa tcctggtccc   3468

 attaactcca agtgcctttt tgacagtgac aacagacagt ccctcgcttt ttgttgttgt   3528

 tggttttctt aaccccttta atggaactgc ctggatttta tacagttatt aaaggatgtc   3588

 tcttttgctt taaactgcat gctgccaagt gccatttggg gtcagcatcc tcgtttcaac   3648

 acagtgtgat ctctagttat catgtgtaac gtgggttctg tttagcgaag atagactaga   3708

 ggacacgtta gagatgccct tccctgctcc atccctgtgg caccattatg gttttttggc   3768

 tgtttgtata taacggttac gtattaactc tggaatccta tgggctcatc ttgctcaccc   3828

 aatgtgggag tctggtttga gcaagcgagc tgaatgtgac tattaaaaaa aaa          3881




      <210> 138
      <211> 841
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(787)

      <400> 138
 gcacgagctc gactcttagc ttgtcgggga cggtaaccgg gacccggtgt ctgctcctgt     60

 cgccttcgcc tcctaatccc tagccact   atg cgt gag tgc atc tcc atc cac     112
                                  Met Arg Glu Cys Ile Ser Ile His
                                    1               5

 gtt ggc cag gct ggt gtc cag att ggc aat gcc tgc tgg gag ctc tac      160
 Val Gly Gln Ala Gly Val Gln Ile Gly Asn Ala Cys Trp Glu Leu Tyr
      10                  15                  20

 tgc ctg gaa cac ggc atc cag ccc gat ggc cag atg cca agt gac aag      208
 Cys Leu Glu His Gly Ile Gln Pro Asp Gly Gln Met Pro Ser Asp Lys
  25                  30                  35                  40

 acc att ggg gga gga gat gac tcc ttc aac acc ttc ttc agt gag acg      256
 Thr Ile Gly Gly Gly Asp Asp Ser Phe Asn Thr Phe Phe Ser Glu Thr
                  45                  50                  55

 ggc gct ggc aag cac gtg ccc cgg gct gtg ttt gta gac ttg gaa ccc      304
 Gly Ala Gly Lys His Val Pro Arg Ala Val Phe Val Asp Leu Glu Pro
              60                  65                  70

 aca gtc att gat gaa gtt cgc act ggc acc tac cgc cag ctc ttc cac      352
 Thr Val Ile Asp Glu Val Arg Thr Gly Thr Tyr Arg Gln Leu Phe His
          75                  80                  85

 cct gag cag ctc atc aca ggc aag gaa gat gct gcc aat aac tat gcc      400
 Pro Glu Gln Leu Ile Thr Gly Lys Glu Asp Ala Ala Asn Asn Tyr Ala
      90                  95                 100

 cga ggg cac tac acc att ggc aag gag atc att gac ctt gtg ttg gac      448
 Arg Gly His Tyr Thr Ile Gly Lys Glu Ile Ile Asp Leu Val Leu Asp
 105                 110                 115                 120

 cga att cgc aag ctg gct gac cag tgc acc ggt ctt cag ggc ttc ttg      496
 Arg Ile Arg Lys Leu Ala Asp Gln Cys Thr Gly Leu Gln Gly Phe Leu
                 125                 130                 135

 gtt ttc cac agc ttt ggt ggg gga act ggt tct ggg ttc acc tcc ctg      544
 Val Phe His Ser Phe Gly Gly Gly Thr Gly Ser Gly Phe Thr Ser Leu
             140                 145                 150

 ctc atg gaa cgt ctc tca gtt gat tat ggc aag aag tcc aag ctg gag      592
 Leu Met Glu Arg Leu Ser Val Asp Tyr Gly Lys Lys Ser Lys Leu Glu
         155                 160                 165

 ttc tcc att tac cca gca ccc cag gtt tcc aca gct gta gtt gag ccc      640
 Phe Ser Ile Tyr Pro Ala Pro Gln Val Ser Thr Ala Val Val Glu Pro
     170                 175                 180

 tac aac tcc atc ctc acc acc cac acc acc ctg gag cac tct gat tgt      688
 Tyr Asn Ser Ile Leu Thr Thr His Thr Thr Leu Glu His Ser Asp Cys
 185                 190                 195                 200

 gcc ttc atg gta gac aat gag gcc atc tat gac atc tgt cgt aga aac      736
 Ala Phe Met Val Asp Asn Glu Ala Ile Tyr Asp Ile Cys Arg Arg Asn
                 205                 210                 215

 ctc gat atc gag cgc cca acc cta cac tac cca ttg aac cgc ctt atg      784
 Leu Asp Ile Glu Arg Pro Thr Leu His Tyr Pro Leu Asn Arg Leu Met
             220                 225                 230

 tag tcca gactagtgtc ctccatcact gcctatccct gaggattctg aatcggaagc      841
 






      <210> 139
      <211> 1491
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1411)

      <400> 139
 aaggatcctt aattaaatta atcccccccc cccggcccgg cggggccacg ccttttccgg     60

 cccgcagcgc ggcctgggct cccgcgtgtt taaaagtgcg cttgtggctg ctgctgtctt    120

 aactcctgtg cttggcggac agacaggcga g   atg gcg gcg gag gtg ttg ccg     172
                                      Met Ala Ala Glu Val Leu Pro
                                        1               5

 agt gcg agg tgg cag tat tgt ggg gcg ccc gac ggg agc cag aga gct      220
 Ser Ala Arg Trp Gln Tyr Cys Gly Ala Pro Asp Gly Ser Gln Arg Ala
          10                  15                  20

 gta ctg gtc cag ttc tcc aac ggg aag cta cag agt cca ggc aac atg      268
 Val Leu Val Gln Phe Ser Asn Gly Lys Leu Gln Ser Pro Gly Asn Met
      25                  30                  35

 cgc ttt acc ttg tat gag aac aaa gat tcc acc aac ccc agg aag agg      316
 Arg Phe Thr Leu Tyr Glu Asn Lys Asp Ser Thr Asn Pro Arg Lys Arg
  40                  45                  50                  55

 aat caa cgg atc ctg gca gct gaa aca gat agg ctc tcc tat gtg gga      364
 Asn Gln Arg Ile Leu Ala Ala Glu Thr Asp Arg Leu Ser Tyr Val Gly
                  60                  65                  70

 aac aat ttt ggg act gga gcc ctc aaa tgc aac act ttg tgc agg cac      412
 Asn Asn Phe Gly Thr Gly Ala Leu Lys Cys Asn Thr Leu Cys Arg His
              75                  80                  85

 ttt gtg gga att ttg aac aag acc tct ggc caa atg gaa gta tat gat      460
 Phe Val Gly Ile Leu Asn Lys Thr Ser Gly Gln Met Glu Val Tyr Asp
          90                  95                 100

 gct gaa ttg ttc aac atg cag cca cta ttt tca gat gta tca gtt gag      508
 Ala Glu Leu Phe Asn Met Gln Pro Leu Phe Ser Asp Val Ser Val Glu
     105                 110                 115

 agt gaa ctg gcg cta gag agt cag acc aaa act tac aga gaa aag atg      556
 Ser Glu Leu Ala Leu Glu Ser Gln Thr Lys Thr Tyr Arg Glu Lys Met
 120                 125                 130                 135

 gat tct tgt att gaa gcc ttt ggt acc acc aaa cag aag cga gct ctg      604
 Asp Ser Cys Ile Glu Ala Phe Gly Thr Thr Lys Gln Lys Arg Ala Leu
                 140                 145                 150

 aac acc agg aga atg aac aga gtt ggc aat gaa tct ttg aat cgt gca      652
 Asn Thr Arg Arg Met Asn Arg Val Gly Asn Glu Ser Leu Asn Arg Ala
             155                 160                 165

 gtg gct aaa gct gca gag act atc att gat acg aag ggt gtg act gct      700
 Val Ala Lys Ala Ala Glu Thr Ile Ile Asp Thr Lys Gly Val Thr Ala
         170                 175                 180

 ctg gtc agc gat gct atc cac aat gac ttg caa gat gac tcc ctc tac      748
 Leu Val Ser Asp Ala Ile His Asn Asp Leu Gln Asp Asp Ser Leu Tyr
     185                 190                 195

 ctt cct ccc tgc tat gat gat gca gcc aag cct gaa gac gtg tat aaa      796
 Leu Pro Pro Cys Tyr Asp Asp Ala Ala Lys Pro Glu Asp Val Tyr Lys
 200                 205                 210                 215

 ttt gaa gat ctt ctt tcc cct gcg gag tat gaa gct ctt cag agc cca      844
 Phe Glu Asp Leu Leu Ser Pro Ala Glu Tyr Glu Ala Leu Gln Ser Pro
                 220                 225                 230

 tct gaa gct ttc agg aac gtc acg tca gaa gaa ata ctg aag atg att      892
 Ser Glu Ala Phe Arg Asn Val Thr Ser Glu Glu Ile Leu Lys Met Ile
             235                 240                 245

 gag gag aac agc cat tgc acc ttt gtc ata gaa gcg ttg aag tct ttg      940
 Glu Glu Asn Ser His Cys Thr Phe Val Ile Glu Ala Leu Lys Ser Leu
         250                 255                 260

 cca tca gat gtg gag agc cga gac cgc cag gcc cga tgc ata tgg ttt      988
 Pro Ser Asp Val Glu Ser Arg Asp Arg Gln Ala Arg Cys Ile Trp Phe
     265                 270                 275

 ctg gat acc ctc atc aaa ttt cga gct cat agg gta gtt aag cgg aaa     1036
 Leu Asp Thr Leu Ile Lys Phe Arg Ala His Arg Val Val Lys Arg Lys
 280                 285                 290                 295

 agt gct ctg gga cct gga gtt ccc cac atc atc aac acc aaa ctg ctg     1084
 Ser Ala Leu Gly Pro Gly Val Pro His Ile Ile Asn Thr Lys Leu Leu
                 300                 305                 310

 aag cac ttt act tgc ttg acc tac aac aat ggc aga tta cgg aac tta     1132
 Lys His Phe Thr Cys Leu Thr Tyr Asn Asn Gly Arg Leu Arg Asn Leu
             315                 320                 325

 att tcg gat tct atg aag gcg aag att act gca tat gtg atc ata ctt     1180
 Ile Ser Asp Ser Met Lys Ala Lys Ile Thr Ala Tyr Val Ile Ile Leu
         330                 335                 340

 gcc ttg cac ata cat gac ttc caa att gac ctg aca gtg tta cag agg     1228
 Ala Leu His Ile His Asp Phe Gln Ile Asp Leu Thr Val Leu Gln Arg
     345                 350                 355

 gac ttg aag ctc agt gag aaa agg atg atg gag ata gcc aaa gcc atg     1276
 Asp Leu Lys Leu Ser Glu Lys Arg Met Met Glu Ile Ala Lys Ala Met
 360                 365                 370                 375

 agg ctg aag atc tcc aaa aga agg gtg tct gtg gcc gcc ggc agt gaa     1324
 Arg Leu Lys Ile Ser Lys Arg Arg Val Ser Val Ala Ala Gly Ser Glu
                 380                 385                 390

 gaa gat cac aaa ctg ggc acc ctg tcc ctc ccg ctg cct cca gcc cag     1372
 Glu Asp His Lys Leu Gly Thr Leu Ser Leu Pro Leu Pro Pro Ala Gln
             395                 400                 405

 acc tca gac cgc ctg gca aag cgg agg aag att acc tag acgcatgctt      1421
 Thr Ser Asp Arg Leu Ala Lys Arg Arg Lys Ile Thr 
         410                 415

 tccagacagg gcgttttggc tgcatcacag ccactggctg gtcctattca tttccatttt   1481

 tatgtatgtt                                                          1491




      <210> 140
      <211> 2310
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1374)

      <400> 140
  atg gcc cgg cgg cgg cgc cgc gcc tgc atc gct ctg ttc ctg gtg ctg      48
  Met Ala Arg Arg Arg Arg Arg Ala Cys Ile Ala Leu Phe Leu Val Leu
    1               5                  10                  15

 ctc ttc gcc ttc ggc acc ctc atg ggt ctg cgc acg ctc aag gct ccg       96
 Leu Phe Ala Phe Gly Thr Leu Met Gly Leu Arg Thr Leu Lys Ala Pro
              20                  25                  30

 gac gga ctc ccg gcg ctg ggc ccg ggc ctg gag ctg gcg ccc ttt gag      144
 Asp Gly Leu Pro Ala Leu Gly Pro Gly Leu Glu Leu Ala Pro Phe Glu
          35                  40                  45

 cga cgc cca gag ggg gcc ccc gcg ccc gct gcc agg gcc ccg gca gcc      192
 Arg Arg Pro Glu Gly Ala Pro Ala Pro Ala Ala Arg Ala Pro Ala Ala
      50                  55                  60

 cct gcc gcg ccg ccc ccg ccg ccg ccg ccg ccc cgc acc gcg gac cct      240
 Pro Ala Ala Pro Pro Pro Pro Pro Pro Pro Pro Arg Thr Ala Asp Pro
  65                  70                  75                  80

 ggc ggc tcc cct ggg ccg gca ccc gcg gag gcc gag ccc gcc ccc gtg      288
 Gly Gly Ser Pro Gly Pro Ala Pro Ala Glu Ala Glu Pro Ala Pro Val
                  85                  90                  95

 cag agc ctg cgc gtc tac tcg gac ctg cac gcc ttc tac tac tcg tgg      336
 Gln Ser Leu Arg Val Tyr Ser Asp Leu His Ala Phe Tyr Tyr Ser Trp
             100                 105                 110

 tac ggg agc ccg cgg cgc gag ggc cac tac att cac tgg gac cac gtc      384
 Tyr Gly Ser Pro Arg Arg Glu Gly His Tyr Ile His Trp Asp His Val
         115                 120                 125

 atg gtg ccg cac tgg gac ccc aag atc tcg gcc agc tac ccc cgc ggc      432
 Met Val Pro His Trp Asp Pro Lys Ile Ser Ala Ser Tyr Pro Arg Gly
     130                 135                 140

 cgc cac agc ccc cca gac gac ttg ggc tcc agc ttc tac ccg gag ctg      480
 Arg His Ser Pro Pro Asp Asp Leu Gly Ser Ser Phe Tyr Pro Glu Leu
 145                 150                 155                 160

 ggg ccc tac agc tcc cgg gac ccc gaa gtg ctg cgg gag cat atg acc      528
 Gly Pro Tyr Ser Ser Arg Asp Pro Glu Val Leu Arg Glu His Met Thr
                 165                 170                 175

 cag ctc aag gaa gcc gcc atc ggc gtc ctg gtc ctg tcc tgg tac cca      576
 Gln Leu Lys Glu Ala Ala Ile Gly Val Leu Val Leu Ser Trp Tyr Pro
             180                 185                 190

 cct ggc atg gct gat gat aac ggg gag ccc tca gat gac ctg gtg ccc      624
 Pro Gly Met Ala Asp Asp Asn Gly Glu Pro Ser Asp Asp Leu Val Pro
         195                 200                 205

 gcc att ctg gac acc gcc cat cag tac agc atc cag gtg gcc ttc cac      672
 Ala Ile Leu Asp Thr Ala His Gln Tyr Ser Ile Gln Val Ala Phe His
     210                 215                 220

 atc caa ccc tac aag ggc cgg gat gac atc act gta cat gac aac atc      720
 Ile Gln Pro Tyr Lys Gly Arg Asp Asp Ile Thr Val His Asp Asn Ile
 225                 230                 235                 240

 aag tac atc att gac acg tat ggc tcc cat ggt gca ttt tac cgc tat      768
 Lys Tyr Ile Ile Asp Thr Tyr Gly Ser His Gly Ala Phe Tyr Arg Tyr
                 245                 250                 255

 aag aac agc atg ggc aag agc ctc cca ctc ttt tat atc tac gac tca      816
 Lys Asn Ser Met Gly Lys Ser Leu Pro Leu Phe Tyr Ile Tyr Asp Ser
             260                 265                 270

 tac ctg acg tcc cct gag gcc tgg gcc cac ctc ctg aca cca aac ggg      864
 Tyr Leu Thr Ser Pro Glu Ala Trp Ala His Leu Leu Thr Pro Asn Gly
         275                 280                 285

 ccc cat tcg atc cgc aac acg ccc tac gat ggg gtc ttc ata gcg ctg      912
 Pro His Ser Ile Arg Asn Thr Pro Tyr Asp Gly Val Phe Ile Ala Leu
     290                 295                 300

 ctg gtg gag gag ggc cac acc cac gat atc ctg gcc gcc gga ttt gac      960
 Leu Val Glu Glu Gly His Thr His Asp Ile Leu Ala Ala Gly Phe Asp
 305                 310                 315                 320

 ggc atg tac acc tac ttt gcc tcc aat ggt ttc tcc ttt ggt tct tcc     1008
 Gly Met Tyr Thr Tyr Phe Ala Ser Asn Gly Phe Ser Phe Gly Ser Ser
                 325                 330                 335

 cat cag aac tgg aaa gct gtg aag aac ttt tgt gat gcc aac aac ctc     1056
 His Gln Asn Trp Lys Ala Val Lys Asn Phe Cys Asp Ala Asn Asn Leu
             340                 345                 350

 atg ttc atc ccc agt gtg ggg cct ggc tac ata gac acc agc att cgg     1104
 Met Phe Ile Pro Ser Val Gly Pro Gly Tyr Ile Asp Thr Ser Ile Arg
         355                 360                 365

 ccc tgg aac aac cac aat acg cgc aac agg gtc aat ggc aag tac tat     1152
 Pro Trp Asn Asn His Asn Thr Arg Asn Arg Val Asn Gly Lys Tyr Tyr
     370                 375                 380

 gag acg gcc ctg cag gcg gcc ctg aca gtg agg ccc gag atc gtt tcc     1200
 Glu Thr Ala Leu Gln Ala Ala Leu Thr Val Arg Pro Glu Ile Val Ser
 385                 390                 395                 400

 att acc tcc ttc aat gag tgg cac gag ggc acc cag att gag aag gcc     1248
 Ile Thr Ser Phe Asn Glu Trp His Glu Gly Thr Gln Ile Glu Lys Ala
                 405                 410                 415

 att ccc aag aag aca ccc acc cgc ctg tat ttg gac tac ctg cct cac     1296
 Ile Pro Lys Lys Thr Pro Thr Arg Leu Tyr Leu Asp Tyr Leu Pro His
             420                 425                 430

 cag ccc agc ctg tac ctg gag ctg aca cgc cgc tgg gcg gag cac ttc     1344
 Gln Pro Ser Leu Tyr Leu Glu Leu Thr Arg Arg Trp Ala Glu His Phe
         435                 440                 445

 atc aaa gag aag gag cag tgg ctc atg tga g gggcctgtaa atgggcgtga     1395
 Ile Lys Glu Lys Glu Gln Trp Leu Met 
     450                 455

 ggtgctgatg tccttgcctt gctggaagat gtcaccatgt ggggttcagc tgaggttgta   1455

 gccactcact cgttcccagg tcagaggtca gcagatgggt gtttctgggt gggccgtcag   1515

 gcatgggcct gtgcaacaca gagcccgttc ctcaggcgag tggtgctgag gtgctctgtg   1575

 gtgatgggaa cggcagaggc tggcaggtga ctgaacttag cccagggcag ctccacatcc   1635

 tgggaacact ttcatgtaac cccttctagt tttgaactct gcagcaggct ggtgctgtgt   1695

 agtggccacc cagtcaccac ccttggaagg gtgtcagggt ctgggctcgc atgcaccctg   1755

 ctcccttctg ccagcctgca tcctctcctc aggcctcctt cccacatcat ctgtcttctc   1815

 taagttaggg aaccatattt gagactttca aaaagggaac ttctaggttt aagctcctcc   1875

 cagtagattc ctgaacccaa ttatcaggaa atcatcctga gcactcacag gttcatttaa   1935

 cactcactca tcaagcacct tcctatgtgc taggtgctgg ggaaaacttg accaaggaag   1995

 agttcctgtc ctgaagcttc caggacccag ctttcctttt ctggtgtggc cttgtagcta   2055

 gtgcctgggc acaggtgttt ttctttttgc agttttacct agtgctggga gttcagttct   2115

 ttttcctcta gaaaaatacc tctgtgctcc agagcctaat ttttcccaga tgcatattta   2175

 gctctaggga gaggactagg aggaaatccc cctcccttta gctgcctgaa ctgaggccca   2235

 ctcactagag ccatgttcag tgctactgtg attagtagta attaaatatg aactggtatt   2295

 ctcaaaaaaa aaaaa                                                    2310




      <210> 141
      <211> 7244
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (714)..(6518)

      <400> 141
 gaccatcacc ctaacaccca gcgcagagac agatgtatcc ctgtgtctac ctgtggcttc     60

 atctacccaa tgctgcctgg agtggccatg tgtggaccag tgtgcttgag tgatgtggcc    120

 tgtgtggacg cgggcccagc gcctacacgt ccttgccctg gatgtgccct gtgtgccctg    180

 acactgtgat gaacatggag tgagtgtgtg tgtgcgcttg tggttgtgct catcagtgag    240

 aatgtgagac tgctgtgctg tgctgcagct gccctgtggt ctgctctgcc tcttccctct    300

 gcctgtgtgc tgtggaccac aatgtattgc atgtagatga tccatgtggc catgctcaac    360

 tggctctgtg catgtgccct gtggcacatg ctgagctaac tacttgcttg tgtgtgatct    420

 gtgacttgtg ttgttgccat gtgatggtgc atgctgagat ctccttcttc ttcctggagc    480

 cctacctgct cgtcgtcctg cacctcctat tcttcctgcc tggtgcttgc ttggcagacc    540

 agggctgtgg ctggtgcctg accatgtgcc accttgccac cttgcgccag ggctgtgagc    600

 ccattgctgg gggattgacc ggtgcttggt gtggtccctg cttgggtgct tggttgccta    660

 ccctcttgcc actctgctga tggagcatct gtggacttgc cacgcctgca ccc   atg     716
                                                              Met
                                                                1

 gac ccc ttc tgt gag tgg cat cag agc acc agc cgc aaa ggg gac gcg      764
 Asp Pro Phe Cys Glu Trp His Gln Ser Thr Ser Arg Lys Gly Asp Ala
               5                  10                  15

 gca tgc agc cgg cgg ggc cgg ggt cgg ggt gcc ctg aag agt cca gag      812
 Ala Cys Ser Arg Arg Gly Arg Gly Arg Gly Ala Leu Lys Ser Pro Glu
          20                  25                  30

 gag tgt ccc ccg ctc tgc agc cag cga ctg acc tgt gag gac tgc ctg      860
 Glu Cys Pro Pro Leu Cys Ser Gln Arg Leu Thr Cys Glu Asp Cys Leu
      35                  40                  45

 gcc aac tct agc cag tgc gcc tgg tgc cag tcc acc cac acc tgc ttc      908
 Ala Asn Ser Ser Gln Cys Ala Trp Cys Gln Ser Thr His Thr Cys Phe
  50                  55                  60                  65

 ctg ttt gct gcc tac ttg gcc cgg tac cca cac ggg ggc tgt cga ggc      956
 Leu Phe Ala Ala Tyr Leu Ala Arg Tyr Pro His Gly Gly Cys Arg Gly
                  70                  75                  80

 tgg gac gac agt gta cac tcg gag cca cgg tgc cgg agc tgc gat ggc     1004
 Trp Asp Asp Ser Val His Ser Glu Pro Arg Cys Arg Ser Cys Asp Gly
              85                  90                  95

 ttc ctg acc tgc cat gag tgt ctg cag agc cac gag tgt ggc tgg tgt     1052
 Phe Leu Thr Cys His Glu Cys Leu Gln Ser His Glu Cys Gly Trp Cys
         100                 105                 110

 ggc aat gag gac aac ccc aca ctg gga cgg tgc cta cag ggg gac ttc     1100
 Gly Asn Glu Asp Asn Pro Thr Leu Gly Arg Cys Leu Gln Gly Asp Phe
     115                 120                 125

 tca ggg ccc ctc ggt ggg ggt aac tgc tcc ctg tgg gtg ggg gag ggc     1148
 Ser Gly Pro Leu Gly Gly Gly Asn Cys Ser Leu Trp Val Gly Glu Gly
 130                 135                 140                 145

 ctg ggg ctt ccc gtg gcc ctc cct gcc cgc tgg gca tac gcc cgc tgt     1196
 Leu Gly Leu Pro Val Ala Leu Pro Ala Arg Trp Ala Tyr Ala Arg Cys
                 150                 155                 160

 cct gac gtg gat gag tgt cgc ctg ggc ctg gcc cgg tgc cac ccg cgg     1244
 Pro Asp Val Asp Glu Cys Arg Leu Gly Leu Ala Arg Cys His Pro Arg
             165                 170                 175

 gcg acc tgc ctg aac acg ccc ctc agc tac gag tgt cac tgc cag cgg     1292
 Ala Thr Cys Leu Asn Thr Pro Leu Ser Tyr Glu Cys His Cys Gln Arg
         180                 185                 190

 ggc tac cag ggt gat ggc atc tca cac tgc aac cgc acg tgc ttg gag     1340
 Gly Tyr Gln Gly Asp Gly Ile Ser His Cys Asn Arg Thr Cys Leu Glu
     195                 200                 205

 gac tgt ggc cat ggt gtg tgc agt ggc ccc ccg gac ttt acc tgc gtg     1388
 Asp Cys Gly His Gly Val Cys Ser Gly Pro Pro Asp Phe Thr Cys Val
 210                 215                 220                 225

 tgt gac cta ggc tgg aca tca gac ctg ccc cct ccc aca ccc gcc ccg     1436
 Cys Asp Leu Gly Trp Thr Ser Asp Leu Pro Pro Pro Thr Pro Ala Pro
                 230                 235                 240

 ggt ccg cca gcc ccc cgc tgc tcc cgg gac tgt ggc tgc agc ttc cac     1484
 Gly Pro Pro Ala Pro Arg Cys Ser Arg Asp Cys Gly Cys Ser Phe His
             245                 250                 255

 agc cac tgc cgc aag cgg ggc cct ggc ttc tgc gac gag tgc cag gac     1532
 Ser His Cys Arg Lys Arg Gly Pro Gly Phe Cys Asp Glu Cys Gln Asp
         260                 265                 270

 tgg aca tgg ggg gag cac tgc gaa cga tgc cgg ccc ggc agc ttc ggc     1580
 Trp Thr Trp Gly Glu His Cys Glu Arg Cys Arg Pro Gly Ser Phe Gly
     275                 280                 285

 aac gcc aca ggc tct agg ggc tgc cgg ccc tgc cag tgc aac ggg cac     1628
 Asn Ala Thr Gly Ser Arg Gly Cys Arg Pro Cys Gln Cys Asn Gly His
 290                 295                 300                 305

 ggg gac cca cgc cgt ggc cac tgc gac aac ctc agt ggg ctc tgc ttc     1676
 Gly Asp Pro Arg Arg Gly His Cys Asp Asn Leu Ser Gly Leu Cys Phe
                 310                 315                 320

 tgc cag gac cac acc gag ggt gcc cac tgc cag ctc tgc tcc cca ggc     1724
 Cys Gln Asp His Thr Glu Gly Ala His Cys Gln Leu Cys Ser Pro Gly
             325                 330                 335

 tat tat ggg gat ccc cgg gcc ggt ggt tcc tgc ttt cgg gag tgt ggg     1772
 Tyr Tyr Gly Asp Pro Arg Ala Gly Gly Ser Cys Phe Arg Glu Cys Gly
         340                 345                 350

 ggt cgc gcc ctc ctc acc aac gtg tcc tca gtg gca ctg ggc tca cgc     1820
 Gly Arg Ala Leu Leu Thr Asn Val Ser Ser Val Ala Leu Gly Ser Arg
     355                 360                 365

 cgg gtc ggg ggg ctg ctg cct cca ggt ggc ggg gct gca aga gcc ggg     1868
 Arg Val Gly Gly Leu Leu Pro Pro Gly Gly Gly Ala Ala Arg Ala Gly
 370                 375                 380                 385

 cct ggc ctg tcc tac tgt gtg tgg gtt gtc tcg gcc act gag gag cta     1916
 Pro Gly Leu Ser Tyr Cys Val Trp Val Val Ser Ala Thr Glu Glu Leu
                 390                 395                 400

 cag ccc tgt gct ccc ggg acc ctc tgt ccc cca ctc acc ctc acc ttc     1964
 Gln Pro Cys Ala Pro Gly Thr Leu Cys Pro Pro Leu Thr Leu Thr Phe
             405                 410                 415

 tcc ccc gac agc agc acc ccc tgc acg ctg agc tac gtc ctg gcg ttt     2012
 Ser Pro Asp Ser Ser Thr Pro Cys Thr Leu Ser Tyr Val Leu Ala Phe
         420                 425                 430

 gat gga ttc cca cgc ttc ctg gac act ggt gtt gtc cag tcg gac cgc     2060
 Asp Gly Phe Pro Arg Phe Leu Asp Thr Gly Val Val Gln Ser Asp Arg
     435                 440                 445

 agc ctc ata gct gcc ttc tgc ggc cag cga cgg gac agg ccc ctc act     2108
 Ser Leu Ile Ala Ala Phe Cys Gly Gln Arg Arg Asp Arg Pro Leu Thr
 450                 455                 460                 465

 gtt cag gcc ctg tct ggg ctg ctc gtg ctg cac tgg gag gcc aat ggc     2156
 Val Gln Ala Leu Ser Gly Leu Leu Val Leu His Trp Glu Ala Asn Gly
                 470                 475                 480

 tcc tca tcc tgg ggc ttc aat gct tcg gtg ggc tct gcc cgc tgt ggg     2204
 Ser Ser Ser Trp Gly Phe Asn Ala Ser Val Gly Ser Ala Arg Cys Gly
             485                 490                 495

 tca ggg ggc ccc ggg agc tgt ccc gtc ccc cag gaa tgc gtg ccc cag     2252
 Ser Gly Gly Pro Gly Ser Cys Pro Val Pro Gln Glu Cys Val Pro Gln
         500                 505                 510

 gac ggt gct gca ggt gcg ggg ctc tgc cga tgt cct cag ggc tgg gct     2300
 Asp Gly Ala Ala Gly Ala Gly Leu Cys Arg Cys Pro Gln Gly Trp Ala
     515                 520                 525

 ggc cca cac tgc cgc atg gct ctg tgt cct gag aac tgc aat gcc cac     2348
 Gly Pro His Cys Arg Met Ala Leu Cys Pro Glu Asn Cys Asn Ala His
 530                 535                 540                 545

 act ggg gca gga act tgt aac cag agc ctg ggt gtg tgc atc tgt gcc     2396
 Thr Gly Ala Gly Thr Cys Asn Gln Ser Leu Gly Val Cys Ile Cys Ala
                 550                 555                 560

 gag ggc ttc ggg ggc ccc gac tgc gcc acc aag ctg gat ggc ggg cag     2444
 Glu Gly Phe Gly Gly Pro Asp Cys Ala Thr Lys Leu Asp Gly Gly Gln
             565                 570                 575

 ctg gtc tgg gag acc ctc atg gac agc cgc ctc tca gcc gac act gcc     2492
 Leu Val Trp Glu Thr Leu Met Asp Ser Arg Leu Ser Ala Asp Thr Ala
         580                 585                 590

 agc cgc ttc ctg cac cgc ctg ggc cac acc atg gtg gat gga ccc gat     2540
 Ser Arg Phe Leu His Arg Leu Gly His Thr Met Val Asp Gly Pro Asp
     595                 600                 605

 gcc acc ttg tgg atg ttt ggg ggc ctg ggc ctg ccc cag ggg ctg ctg     2588
 Ala Thr Leu Trp Met Phe Gly Gly Leu Gly Leu Pro Gln Gly Leu Leu
 610                 615                 620                 625

 gga aac ctg tac agg tac tca gtg agt gag cgg cgg tgg aca cag atg     2636
 Gly Asn Leu Tyr Arg Tyr Ser Val Ser Glu Arg Arg Trp Thr Gln Met
                 630                 635                 640

 ctg gcg gga gcc gag gac ggg ggc cca ggc cca tcg ccc cgc tcc ttc     2684
 Leu Ala Gly Ala Glu Asp Gly Gly Pro Gly Pro Ser Pro Arg Ser Phe
             645                 650                 655

 cat gca gcc gca tat gtg ccc gct ggc cgt ggt gcc atg tat ctg ctg     2732
 His Ala Ala Ala Tyr Val Pro Ala Gly Arg Gly Ala Met Tyr Leu Leu
         660                 665                 670

 ggg gga ctt acc gct gga ggc gtc acc cgt gat ttc tgg gtc ctc aac     2780
 Gly Gly Leu Thr Ala Gly Gly Val Thr Arg Asp Phe Trp Val Leu Asn
     675                 680                 685

 ctc acc acc ctg caa tgg cgg cag gag aag gcc ccc cag acc gtg gag     2828
 Leu Thr Thr Leu Gln Trp Arg Gln Glu Lys Ala Pro Gln Thr Val Glu
 690                 695                 700                 705

 ctg cca gcc gtt gct ggt cac acc ctt act gcc cgc cga ggc ctg tct     2876
 Leu Pro Ala Val Ala Gly His Thr Leu Thr Ala Arg Arg Gly Leu Ser
                 710                 715                 720

 ctg ctc ctg gtg ggc ggt tac tcc ccg gaa aat ggc ttc aac cag cag     2924
 Leu Leu Leu Val Gly Gly Tyr Ser Pro Glu Asn Gly Phe Asn Gln Gln
             725                 730                 735

 ctg ctg gag tac cag ctg gca acc ggc acc tgg gtg tca gga gcc cag     2972
 Leu Leu Glu Tyr Gln Leu Ala Thr Gly Thr Trp Val Ser Gly Ala Gln
         740                 745                 750

 agt ggg aca ccc ccc aca ggt ctc tat ggt cac tct gct gtc tac cac     3020
 Ser Gly Thr Pro Pro Thr Gly Leu Tyr Gly His Ser Ala Val Tyr His
     755                 760                 765

 gag gcc acc gac tcc ctc tac gtg ttt ggg ggg ttc cga ttc cat gtg     3068
 Glu Ala Thr Asp Ser Leu Tyr Val Phe Gly Gly Phe Arg Phe His Val
 770                 775                 780                 785

 gag ctg gcg gcc cca tcc ccc gag ctc tac tcc ctg cac tgt cct gac     3116
 Glu Leu Ala Ala Pro Ser Pro Glu Leu Tyr Ser Leu His Cys Pro Asp
                 790                 795                 800

 cgc acc tgg agt ctg ctg gcc cct tct cag ggg gca aag cga gat cgt     3164
 Arg Thr Trp Ser Leu Leu Ala Pro Ser Gln Gly Ala Lys Arg Asp Arg
             805                 810                 815

 atg agg aat gtg cgt ggc tca tct cgg ggt ctg ggc caa gtt cct ggg     3212
 Met Arg Asn Val Arg Gly Ser Ser Arg Gly Leu Gly Gln Val Pro Gly
         820                 825                 830

 gag cag cct ggg tca tgg ggg ttc cgg gaa gtc agg aag aag atg gct     3260
 Glu Gln Pro Gly Ser Trp Gly Phe Arg Glu Val Arg Lys Lys Met Ala
     835                 840                 845

 ctg tgg gct gct ctt gct ggt aca gga ggt ttc ctg gag gaa atc tca     3308
 Leu Trp Ala Ala Leu Ala Gly Thr Gly Gly Phe Leu Glu Glu Ile Ser
 850                 855                 860                 865

 cct cac ctg aag gag ccc cgc ccc cgg ctt ttc cac gcc tca gcc ctg     3356
 Pro His Leu Lys Glu Pro Arg Pro Arg Leu Phe His Ala Ser Ala Leu
                 870                 875                 880

 tta ggg gac acc atg gtg gtt ctt ggg ggg cgc tcg gac cct gac gag     3404
 Leu Gly Asp Thr Met Val Val Leu Gly Gly Arg Ser Asp Pro Asp Glu
             885                 890                 895

 ttc agc agc gac gtt ctg ctc tac cag gtc aac tgc aat gcc tgg ctt     3452
 Phe Ser Ser Asp Val Leu Leu Tyr Gln Val Asn Cys Asn Ala Trp Leu
         900                 905                 910

 ctg ccc gac ctc acc cgc tcg gcc tct gtg ggg ccc cca atg gag gag     3500
 Leu Pro Asp Leu Thr Arg Ser Ala Ser Val Gly Pro Pro Met Glu Glu
     915                 920                 925

 tct gtg gcc cat gct gtg gca gca gtc ggg agc cgc ctg tat atc tct     3548
 Ser Val Ala His Ala Val Ala Ala Val Gly Ser Arg Leu Tyr Ile Ser
 930                 935                 940                 945

 ggg ggt ttc ggg gga gtg gcc ctg ggc cgc ctg ctg gca ctg acc ctg     3596
 Gly Gly Phe Gly Gly Val Ala Leu Gly Arg Leu Leu Ala Leu Thr Leu
                 950                 955                 960

 ccc cct gac ccc tgc cgc ctg ctg tcc tca cct gaa gct tgt aac cag     3644
 Pro Pro Asp Pro Cys Arg Leu Leu Ser Ser Pro Glu Ala Cys Asn Gln
             965                 970                 975

 tct ggg gcc tgc acc tgg tgc cat ggg gcc tgc ttg tcc ggg gat cag     3692
 Ser Gly Ala Cys Thr Trp Cys His Gly Ala Cys Leu Ser Gly Asp Gln
         980                 985                 990

 gcc cac agg ctg ggc tgc ggg ggc tcc ccc tgc tcc cca atg cct cgc     3740
 Ala His Arg Leu Gly Cys Gly Gly Ser Pro Cys Ser Pro Met Pro Arg
     995                1000                1005

 tcc ccg gag gaa tgt cga cgt ctc cgg acc tgc agt gag tgc ctg gcc     3788
 Ser Pro Glu Glu Cys Arg Arg Leu Arg Thr Cys Ser Glu Cys Leu Ala
1010                1015                1020                1025

 cgc cat cct cgg acc ctg caa cct gga gat gga gag gcg tcc acc ccc     3836
 Arg His Pro Arg Thr Leu Gln Pro Gly Asp Gly Glu Ala Ser Thr Pro
                1030                1035                1040

 cgc tgt aag tgg tgt acc aac tgc ccc gaa ggt gct tgc att gga cgc     3884
 Arg Cys Lys Trp Cys Thr Asn Cys Pro Glu Gly Ala Cys Ile Gly Arg
            1045                1050                1055

 aat ggg tcc tgc acc tct gag aat gac tgt cgg atc aac cag cga gag     3932
 Asn Gly Ser Cys Thr Ser Glu Asn Asp Cys Arg Ile Asn Gln Arg Glu
        1060                1065                1070

 gtc ttc tgg gca ggg aac tgc tcc gag gct gcg tgc ggg gct gct gac     3980
 Val Phe Trp Ala Gly Asn Cys Ser Glu Ala Ala Cys Gly Ala Ala Asp
    1075                1080                1085

 tgc gag cag tgc acg cgg gag ggc aag tgc atg tgg acg cgg cag ttc     4028
 Cys Glu Gln Cys Thr Arg Glu Gly Lys Cys Met Trp Thr Arg Gln Phe
1090                1095                1100                1105

 aag agg aca ggg gag acc cgc cgc atc ctc tcc gtg cag ccc acc tat     4076
 Lys Arg Thr Gly Glu Thr Arg Arg Ile Leu Ser Val Gln Pro Thr Tyr
                1110                1115                1120

 gac tgg acg tgc ttc agc cac tct ctg ctg aat gtg tcc ccc atg ccg     4124
 Asp Trp Thr Cys Phe Ser His Ser Leu Leu Asn Val Ser Pro Met Pro
            1125                1130                1135

 gtg gaa tca tca ccc cca ctg ccc tgc ccc acc cct tgt cac ctc cta     4172
 Val Glu Ser Ser Pro Pro Leu Pro Cys Pro Thr Pro Cys His Leu Leu
        1140                1145                1150

 ccc aac tgt acc tcc tgc ctg gac tct aag gga gca gat ggg ggc tgg     4220
 Pro Asn Cys Thr Ser Cys Leu Asp Ser Lys Gly Ala Asp Gly Gly Trp
    1155                1160                1165

 cag cac tgt gtt tgg agc agc agc ctg cag cag tgt ctg agc cct tcc     4268
 Gln His Cys Val Trp Ser Ser Ser Leu Gln Gln Cys Leu Ser Pro Ser
1170                1175                1180                1185

 tac ctg ccc ctg cga tgt atg gcc gga ggc tgt ggg cgg ctg ctc cgg     4316
 Tyr Leu Pro Leu Arg Cys Met Ala Gly Gly Cys Gly Arg Leu Leu Arg
                1190                1195                1200

 gga cct gag agc tgc tcc ctg ggc tgt gct cag gca act cag tgc gcc     4364
 Gly Pro Glu Ser Cys Ser Leu Gly Cys Ala Gln Ala Thr Gln Cys Ala
            1205                1210                1215

 ttg tgc ctg cgg cgc ccc cat tgc ggc tgg tgt gcc tgg ggg ggc cag     4412
 Leu Cys Leu Arg Arg Pro His Cys Gly Trp Cys Ala Trp Gly Gly Gln
        1220                1225                1230

 gat ggg ggt ggc cgc tgc atg gag ggt gga ctc agc ggc ccc cgt gat     4460
 Asp Gly Gly Gly Arg Cys Met Glu Gly Gly Leu Ser Gly Pro Arg Asp
    1235                1240                1245

 ggg ctg aca tgt ggg cgt ccg ggg gcc tcc tgg gcc ttc ctg tcc tgc     4508
 Gly Leu Thr Cys Gly Arg Pro Gly Ala Ser Trp Ala Phe Leu Ser Cys
1250                1255                1260                1265

 ccc cct gag gac gag tgt gca aac ggg cac cac gac tgc aac gag acg     4556
 Pro Pro Glu Asp Glu Cys Ala Asn Gly His His Asp Cys Asn Glu Thr
                1270                1275                1280

 cag aat tgc cac gac cag ccc cac ggc tat gag tgc agc tgc aag acc     4604
 Gln Asn Cys His Asp Gln Pro His Gly Tyr Glu Cys Ser Cys Lys Thr
            1285                1290                1295

 ggc tat acc atg gac aac atg aca ggg ctg tgc cgc cct gtg tgc gcc     4652
 Gly Tyr Thr Met Asp Asn Met Thr Gly Leu Cys Arg Pro Val Cys Ala
        1300                1305                1310

 cag ggc tgc gtg aac ggc tca tgt gtg gag ccc gac cac tgc cgc tgc     4700
 Gln Gly Cys Val Asn Gly Ser Cys Val Glu Pro Asp His Cys Arg Cys
    1315                1320                1325

 cac ttt ggc ttt gtg ggc cgc aac tgc tcc acg gaa tgc cgc tgc aac     4748
 His Phe Gly Phe Val Gly Arg Asn Cys Ser Thr Glu Cys Arg Cys Asn
1330                1335                1340                1345

 cgc cac agt gaa tgc gct ggt gtt ggg gcg cgt gac cac tgc ttg ctc     4796
 Arg His Ser Glu Cys Ala Gly Val Gly Ala Arg Asp His Cys Leu Leu
                1350                1355                1360

 tgc cgc aac cac acc aag ggc agc cac tgt gag cag tgc ctc ccg ctg     4844
 Cys Arg Asn His Thr Lys Gly Ser His Cys Glu Gln Cys Leu Pro Leu
            1365                1370                1375

 ttt gtg ggt tca gct gtc gga ggc ggg acc tgc cgg ccc tgc cac gcc     4892
 Phe Val Gly Ser Ala Val Gly Gly Gly Thr Cys Arg Pro Cys His Ala
        1380                1385                1390

 ttt tgt cgt gga aat agc cac atc tgc atc tcc agg aag gag tta caa     4940
 Phe Cys Arg Gly Asn Ser His Ile Cys Ile Ser Arg Lys Glu Leu Gln
    1395                1400                1405

 atg tcc aag gga gag cca aag aag tac tca ctg gac cca gag gag att     4988
 Met Ser Lys Gly Glu Pro Lys Lys Tyr Ser Leu Asp Pro Glu Glu Ile
1410                1415                1420                1425

 gaa aac tgg gtg aca gag ggt cct agt gaa gac gag gcc gtg tgc gtg     5036
 Glu Asn Trp Val Thr Glu Gly Pro Ser Glu Asp Glu Ala Val Cys Val
                1430                1435                1440

 aac tgc cag aat aac agc tat ggg gag aaa tgc gag agc tgc ctg cag     5084
 Asn Cys Gln Asn Asn Ser Tyr Gly Glu Lys Cys Glu Ser Cys Leu Gln
            1445                1450                1455

 ggc tac ttc ctc ctg gac ggg aag tgc acc aaa tgc cag tgt aat ggc     5132
 Gly Tyr Phe Leu Leu Asp Gly Lys Cys Thr Lys Cys Gln Cys Asn Gly
        1460                1465                1470

 cac gcg gac aca tgt aac gag cag gat ggg acg ggc tgt cca tgt cag     5180
 His Ala Asp Thr Cys Asn Glu Gln Asp Gly Thr Gly Cys Pro Cys Gln
    1475                1480                1485

 aat aac aca gag acg ggc aca tgc cag ggc agc tcc ccc agt gac cgt     5228
 Asn Asn Thr Glu Thr Gly Thr Cys Gln Gly Ser Ser Pro Ser Asp Arg
1490                1495                1500                1505

 cga gac tgc tac aag tac cag tgc gcc aag tgc cgg gaa tca ttt cac     5276
 Arg Asp Cys Tyr Lys Tyr Gln Cys Ala Lys Cys Arg Glu Ser Phe His
                1510                1515                1520

 ggg agt ccg ctg ggc ggc cag cag tgc tac cgc ctc atc tcg gtg gag     5324
 Gly Ser Pro Leu Gly Gly Gln Gln Cys Tyr Arg Leu Ile Ser Val Glu
            1525                1530                1535

 cag gag tgc tgc ctg gac ccc acg tcc cag acc aac tgc ttc cat gag     5372
 Gln Glu Cys Cys Leu Asp Pro Thr Ser Gln Thr Asn Cys Phe His Glu
        1540                1545                1550

 ccc aaa cgc cgg gcg cta ggc ccc ggc cgc act gtc ctc ttt ggc gtg     5420
 Pro Lys Arg Arg Ala Leu Gly Pro Gly Arg Thr Val Leu Phe Gly Val
    1555                1560                1565

 cag ccc aaa ttc acc aac gtg gac atc cgc ctg acg ctg gac gtg acc     5468
 Gln Pro Lys Phe Thr Asn Val Asp Ile Arg Leu Thr Leu Asp Val Thr
1570                1575                1580                1585

 ttc ggg gcc gtg gac ctc tat gtc tcc acc tcc tat gac acc ttc gtg     5516
 Phe Gly Ala Val Asp Leu Tyr Val Ser Thr Ser Tyr Asp Thr Phe Val
                1590                1595                1600

 gtc cgt gtg gcc cct gac act ggc gtc cat act gta cac atc cag cca     5564
 Val Arg Val Ala Pro Asp Thr Gly Val His Thr Val His Ile Gln Pro
            1605                1610                1615

 ccc cca gcc cca cca cct cca cca ccc cct gca gat ggt ggg ccc cgg     5612
 Pro Pro Ala Pro Pro Pro Pro Pro Pro Pro Ala Asp Gly Gly Pro Arg
        1620                1625                1630

 ggg gct ggg gat cca gga gga gca ggg gcc agc agt ggg ccg ggc gcc     5660
 Gly Ala Gly Asp Pro Gly Gly Ala Gly Ala Ser Ser Gly Pro Gly Ala
    1635                1640                1645

 cca gca gag cca cgg gta cgg gag gta tgg ccg cgg ggc ctg att acc     5708
 Pro Ala Glu Pro Arg Val Arg Glu Val Trp Pro Arg Gly Leu Ile Thr
1650                1655                1660                1665

 tac gtg acg gtg acg gag ccg tcg gca gtg ctg gtg gtc cgc ggc gtg     5756
 Tyr Val Thr Val Thr Glu Pro Ser Ala Val Leu Val Val Arg Gly Val
                1670                1675                1680

 cgg gac cgg ctg gtc atc acc tac cca cac gag cac cat gcc ctc aag     5804
 Arg Asp Arg Leu Val Ile Thr Tyr Pro His Glu His His Ala Leu Lys
            1685                1690                1695

 tcg agc cgc ttc tac ctg ctg ctg ctg ggc gtg gga gac cca agt ggg     5852
 Ser Ser Arg Phe Tyr Leu Leu Leu Leu Gly Val Gly Asp Pro Ser Gly
        1700                1705                1710

 ccc ggc gcc aac ggc tca gcc gac tcg cag ggc ctg ctc ttc ttc cgg     5900
 Pro Gly Ala Asn Gly Ser Ala Asp Ser Gln Gly Leu Leu Phe Phe Arg
    1715                1720                1725

 cag gac cag gcc cac att gac ctg ttt gtc ttc ttc tcc gtc ttc ttc     5948
 Gln Asp Gln Ala His Ile Asp Leu Phe Val Phe Phe Ser Val Phe Phe
1730                1735                1740                1745

 tcc tgc ttc ttc ctc ttc ctc tca ctc tgt gtg ctc ctc tgg aag gcc     5996
 Ser Cys Phe Phe Leu Phe Leu Ser Leu Cys Val Leu Leu Trp Lys Ala
                1750                1755                1760

 aag cag gct ctg gac cag cgg cag gag cag cgc cgg cac ttg cag gag     6044
 Lys Gln Ala Leu Asp Gln Arg Gln Glu Gln Arg Arg His Leu Gln Glu
            1765                1770                1775

 atg acc aag atg gcc agc cgc ccc ttc gcc aag gtc acc gtc tgc ttc     6092
 Met Thr Lys Met Ala Ser Arg Pro Phe Ala Lys Val Thr Val Cys Phe
        1780                1785                1790

 cca cct gac cct act gcc ccg gcc tcc gcc tgg aag ccg gct ggg ctc     6140
 Pro Pro Asp Pro Thr Ala Pro Ala Ser Ala Trp Lys Pro Ala Gly Leu
    1795                1800                1805

 cca cct ccc gcc ttc cgc cgc tct gag ccc ttc ctg gca ccc ctg ctg     6188
 Pro Pro Pro Ala Phe Arg Arg Ser Glu Pro Phe Leu Ala Pro Leu Leu
1810                1815                1820                1825

 ctg aca ggg gcc ggt ggg ccc tgg gga ccc atg gga ggg ggc tgc tgc     6236
 Leu Thr Gly Ala Gly Gly Pro Trp Gly Pro Met Gly Gly Gly Cys Cys
                1830                1835                1840

 cca cca gcc atc ccc gcc acc act gct ggg ctg cga gct ggg ccc atc     6284
 Pro Pro Ala Ile Pro Ala Thr Thr Ala Gly Leu Arg Ala Gly Pro Ile
            1845                1850                1855

 act ctc gag ccc aca gaa gat ggc atg gct ggc gtg gcc aca ctg ctg     6332
 Thr Leu Glu Pro Thr Glu Asp Gly Met Ala Gly Val Ala Thr Leu Leu
        1860                1865                1870

 ctc cag ctg cct ggc ggg ccc cat gca ccc aac ggc gcc tgc ctg ggg     6380
 Leu Gln Leu Pro Gly Gly Pro His Ala Pro Asn Gly Ala Cys Leu Gly
    1875                1880                1885

 tca gcc ctc gtc aca ctg cgg cac agg ctg cac gag tac tgt ggg ggt     6428
 Ser Ala Leu Val Thr Leu Arg His Arg Leu His Glu Tyr Cys Gly Gly
1890                1895                1900                1905

 ggt ggg ggt gct ggg ggc agt ggg cat ggg act ggt gcg ggc cgg aag     6476
 Gly Gly Gly Ala Gly Gly Ser Gly His Gly Thr Gly Ala Gly Arg Lys
                1910                1915                1920

 gga ctg ttg agc cag gac aac ctc acc agc atg tcc ctc tga catgccc     6525
 Gly Leu Leu Ser Gln Asp Asn Leu Thr Ser Met Ser Leu 
            1925                1930

 agggttctca tccacagcag ctgggtcacc tgatagggcc gccctggact tggggtccct   6585

 ccacctgggg gcccctggac actgtctact tggagaccac tggccccctt cccccagggt   6645

 tgcccagatg gggcctcctt tgttctgcat tcagcagcta tttatcgagt acctactctg   6705

 tcaggcactg tcataggcgt ggggcaaagc aggaaccaag agacgaggtt ccctgatctc   6765

 atgggactta ggttctggtg aagggagaca atcagtgcac atgcacacac cccacacgca   6825

 tacacacatg aacacatgca catgtgcaca cacaagtaag atggcttcag agagggagaa   6885

 gcactgtgag gcctccagag gatgtggcag tgagggacga tggggtgaag tcagctgggc   6945

 attcaaagaa gctagactga gaacgcctga gaagaaccag ctacgggaag agctttggga   7005

 agcaaaggca gaggccctgg ggtgggagca ggcttgtttt attggaagga ccagaaaact   7065

 ggtaagtgtg acccagatca agtgtgagga gatgaggctg gggatagtca ggggctggat   7125

 cacccagggc cttgtgggcc ccacataggg ttttgggttt tattctcagg gcaatgggaa   7185

 gctgttggat ggtttgatga aggggagtga caggatccga tgtacctatt taagaattt    7244




      <210> 142
      <211> 2365
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(1861)

      <400> 142
 ggggctgggc ggcggggaca gcggggacgg cacggcgcgc gcagcttcta agtgccag       58                                                                 
 atg atg gag gag cgt gcc aac ctg atg cac atg atg aaa ctc agc atc      106
 Met Met Glu Glu Arg Ala Asn Leu Met His Met Met Lys Leu Ser Ile
   1               5                  10                  15

 aag gtg ttg ctc cag tcg gct ctg agc ctg ggc cgc agc ctg gat gcg      154
 Lys Val Leu Leu Gln Ser Ala Leu Ser Leu Gly Arg Ser Leu Asp Ala
              20                  25                  30

 gac cat gcc ccc ttg cag cag ttc ttt gta gtg atg gag cac tgc ctc      202
 Asp His Ala Pro Leu Gln Gln Phe Phe Val Val Met Glu His Cys Leu
          35                  40                  45

 aaa cat ggg ctg aaa gtt aag aag agt ttt att ggc caa aat aaa tca      250
 Lys His Gly Leu Lys Val Lys Lys Ser Phe Ile Gly Gln Asn Lys Ser
      50                  55                  60

 ttc ttt ggt cct ttg gag ctg gtg gag aaa ctt tgt cca gaa gca tca      298
 Phe Phe Gly Pro Leu Glu Leu Val Glu Lys Leu Cys Pro Glu Ala Ser
  65                  70                  75                  80

 gat ata gcg act agt gtc aga aat ctt cca gaa tta aag aca gct gtg      346
 Asp Ile Ala Thr Ser Val Arg Asn Leu Pro Glu Leu Lys Thr Ala Val
                  85                  90                  95

 gga aga ggc cga gcg tgg ctt tat ctt gca ctc atg caa aag aaa ctg      394
 Gly Arg Gly Arg Ala Trp Leu Tyr Leu Ala Leu Met Gln Lys Lys Leu
             100                 105                 110

 gca gat tat ctg aaa gtg ctt ata gac aat aaa cat ctc tta agc gag      442
 Ala Asp Tyr Leu Lys Val Leu Ile Asp Asn Lys His Leu Leu Ser Glu
         115                 120                 125

 ttc tat gag cct gag gct tta atg atg gag gaa gaa ggg atg gtg att      490
 Phe Tyr Glu Pro Glu Ala Leu Met Met Glu Glu Glu Gly Met Val Ile
     130                 135                 140

 gtt ggt ctg ctg gtg gga ctc aat gtt ctc gat gcc aat ctc tgc ttg      538
 Val Gly Leu Leu Val Gly Leu Asn Val Leu Asp Ala Asn Leu Cys Leu
 145                 150                 155                 160

 aaa gga gaa gac ttg gat tct cag gtt gga gta ata gat ttt tcc ctc      586
 Lys Gly Glu Asp Leu Asp Ser Gln Val Gly Val Ile Asp Phe Ser Leu
                 165                 170                 175

 tac ctt aag gat gtg cag gat ctt gat ggt ggc aag gag cat gaa aga      634
 Tyr Leu Lys Asp Val Gln Asp Leu Asp Gly Gly Lys Glu His Glu Arg
             180                 185                 190

 att act gat gtc ctt gat caa aaa aat tat gtg gaa gaa ctt aac cgg      682
 Ile Thr Asp Val Leu Asp Gln Lys Asn Tyr Val Glu Glu Leu Asn Arg
         195                 200                 205

 cac ttg agc tgc aca gtt ggg gat ctt caa acc aag ata gat ggc ttg      730
 His Leu Ser Cys Thr Val Gly Asp Leu Gln Thr Lys Ile Asp Gly Leu
     210                 215                 220

 gaa aag act aac tca aag ctt caa gaa gag ctt tca gct gca aca gac      778
 Glu Lys Thr Asn Ser Lys Leu Gln Glu Glu Leu Ser Ala Ala Thr Asp
 225                 230                 235                 240

 cga att tgc tca ctt caa gaa gaa cag cag cag tta aga gaa caa aat      826
 Arg Ile Cys Ser Leu Gln Glu Glu Gln Gln Gln Leu Arg Glu Gln Asn
                 245                 250                 255

 gaa tta att cga gaa aga agt gaa aag agt gta gag ata aca aaa cag      874
 Glu Leu Ile Arg Glu Arg Ser Glu Lys Ser Val Glu Ile Thr Lys Gln
             260                 265                 270

 gat acc aaa gtt gag ctg gag act tac aag caa act cgg caa ggt ctg      922
 Asp Thr Lys Val Glu Leu Glu Thr Tyr Lys Gln Thr Arg Gln Gly Leu
         275                 280                 285

 gat gaa atg tac agt gat gtg tgg aag cag cta aaa gag gag aag aaa      970
 Asp Glu Met Tyr Ser Asp Val Trp Lys Gln Leu Lys Glu Glu Lys Lys
     290                 295                 300

 gtc cgg ttg gaa ctg gaa aaa gaa ctg gag tta caa att gga atg aaa     1018
 Val Arg Leu Glu Leu Glu Lys Glu Leu Glu Leu Gln Ile Gly Met Lys
 305                 310                 315                 320

 acc gaa atg gaa att gca atg aag tta ctg gaa aag gac acc cac gag     1066
 Thr Glu Met Glu Ile Ala Met Lys Leu Leu Glu Lys Asp Thr His Glu
                 325                 330                 335

 aag cag gac aca cta gtt gcc ctc cgc cag cag ctg gaa gaa gtc aaa     1114
 Lys Gln Asp Thr Leu Val Ala Leu Arg Gln Gln Leu Glu Glu Val Lys
             340                 345                 350

 gcg att aat tta cag atg ttt cac aaa gct cag aat gca gag agc agt     1162
 Ala Ile Asn Leu Gln Met Phe His Lys Ala Gln Asn Ala Glu Ser Ser
         355                 360                 365

 ttg cag cag aag aat gaa gcc atc aca tcc ttt gaa gga aaa acc aac     1210
 Leu Gln Gln Lys Asn Glu Ala Ile Thr Ser Phe Glu Gly Lys Thr Asn
     370                 375                 380

 caa gtt atg tcc agc atg aaa caa atg gaa gaa agg ttg cag cac tcg     1258
 Gln Val Met Ser Ser Met Lys Gln Met Glu Glu Arg Leu Gln His Ser
 385                 390                 395                 400

 gag cgg gcg agg cag ggg gct gag gag cgg agc cac aag ctg cag cag     1306
 Glu Arg Ala Arg Gln Gly Ala Glu Glu Arg Ser His Lys Leu Gln Gln
                 405                 410                 415

 gag ctg ggc ggg agg atc ggc gcc ctg cag ctg cag ctc tcc cag ctg     1354
 Glu Leu Gly Gly Arg Ile Gly Ala Leu Gln Leu Gln Leu Ser Gln Leu
             420                 425                 430

 cac gag caa tgc tca agc ctg gag aaa gaa ttg aaa tca gaa aaa gag     1402
 His Glu Gln Cys Ser Ser Leu Glu Lys Glu Leu Lys Ser Glu Lys Glu
         435                 440                 445

 caa aga cag gct ctt cag cgc gaa tta cag cac gag aaa gac act tcc     1450
 Gln Arg Gln Ala Leu Gln Arg Glu Leu Gln His Glu Lys Asp Thr Ser
     450                 455                 460

 tct cta ctc agg atg gag ctg caa caa gtg gaa gga ctg aaa aag gag     1498
 Ser Leu Leu Arg Met Glu Leu Gln Gln Val Glu Gly Leu Lys Lys Glu
 465                 470                 475                 480

 ttg cgg gag ctt cag gac gag aag gca gag ctg cag aag atc tgc gag     1546
 Leu Arg Glu Leu Gln Asp Glu Lys Ala Glu Leu Gln Lys Ile Cys Glu
                 485                 490                 495

 gag cag gaa caa gcc ctc cag gaa atg ggc ctg cac ctc agc cag tcc     1594
 Glu Gln Glu Gln Ala Leu Gln Glu Met Gly Leu His Leu Ser Gln Ser
             500                 505                 510

 aag ctg aag atg gaa gat ata aaa gaa gtg aac cag gca ctg aag ggc     1642
 Lys Leu Lys Met Glu Asp Ile Lys Glu Val Asn Gln Ala Leu Lys Gly
         515                 520                 525

 cac gcc tgg ctg aaa gat gac gaa gcg aca cac tgt agg cag tgt gag     1690
 His Ala Trp Leu Lys Asp Asp Glu Ala Thr His Cys Arg Gln Cys Glu
     530                 535                 540

 aag gag ttc tcc att tcc cgg aga aag cac cac tgc cgg aac tgt ggc     1738
 Lys Glu Phe Ser Ile Ser Arg Arg Lys His His Cys Arg Asn Cys Gly
 545                 550                 555                 560

 cac atc ttc tgc aac acc tgc tcc agc aac gag ctg gcc ctg ccc tcc     1786
 His Ile Phe Cys Asn Thr Cys Ser Ser Asn Glu Leu Ala Leu Pro Ser
                 565                 570                 575

 tac ccc aag ccg gtg cga gtg tgc gac agc tgc cac acc ctg ctc ctg     1834
 Tyr Pro Lys Pro Val Arg Val Cys Asp Ser Cys His Thr Leu Leu Leu
             580                 585                 590

 cag cgc tgc tcc tcc acg gcc tcc tga acgtc cgtcctcagg agcacagcct     1886
 Gln Arg Cys Ser Ser Thr Ala Ser 
         595                 600

 cacggacagt gccaaaccct gtgggtctcc aggggcttgg gaaatgtgtt ctttcccaag   1946

 agtatcaaag gaaagaatca aatttcttgc ccggtcactg gcactccaga agacagcgtg   2006

 ccggaaccgg cagctctcac ctttctgtga cttgttcgga attaactcct ctggatggaa   2066

 acttccatct tacttggtta catcacggct ctggttcaga tacaacttca tgattttgct   2126

 actatcattt ttcacttttc aaagaattta acctatttta cagcagttca gttctgctag   2186

 tgagtagttt tcctctccta ccttccttct aaaaacctga ttcatgcacg gcgtttgaca   2246

 cacatggagt ctgccagtgt gccttctctg cttcagacaa gagatctgcc atttcatgcc   2306

 cttgtgacta cctatcattg gccctgcaat aaaatcattt atttttcaaa aaaaaaaaa    2365




      <210> 143
      <211> 2948
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (133)..(1980)

      <400> 143
 ggccgctggt agggccggcc ggccggcggg cggagccccc ccgccgacgc acacgaggtg     60

 accaggcatt gatgcacccc caggaaggcc acgggctcag gaggcccccc cgccccgctg    120

 gctgctgctc ac    atg gtg tct ggg ccc ttg gca ctc cgg tgg tgc gcg     168
                  Met Val Ser Gly Pro Leu Ala Leu Arg Trp Cys Ala
                    1               5                  10

 tgg gca ggg cgc ggg gac atg ggg ccc gac atg gag ctg ccc agc cac      216
 Trp Ala Gly Arg Gly Asp Met Gly Pro Asp Met Glu Leu Pro Ser His
          15                  20                  25

 tcg aag cag ctc ctg ctg cag ctg aac cag cag agg acc aag ggc ttc      264
 Ser Lys Gln Leu Leu Leu Gln Leu Asn Gln Gln Arg Thr Lys Gly Phe
      30                  35                  40

 ctg tgt gac gtc atc atc atg gtg gag aac tcc atc ttc cgg gcc cac      312
 Leu Cys Asp Val Ile Ile Met Val Glu Asn Ser Ile Phe Arg Ala His
  45                  50                  55                  60

 aag aac gtc cta gcc gcc agc agc atc tat ttc aag tcc ctg gtc ctg      360
 Lys Asn Val Leu Ala Ala Ser Ser Ile Tyr Phe Lys Ser Leu Val Leu
                  65                  70                  75

 cac gac aac ctc atc aac ctg gac aca gac atg gtc agc tcc aca gtg      408
 His Asp Asn Leu Ile Asn Leu Asp Thr Asp Met Val Ser Ser Thr Val
              80                  85                  90

 ttc cag cag atc ttg gac ttc atc tac aca ggc aag ctg ctg ccc agc      456
 Phe Gln Gln Ile Leu Asp Phe Ile Tyr Thr Gly Lys Leu Leu Pro Ser
          95                 100                 105

 gac cag cca gcc gag ccc aac ttc agc acc ctc ctc act gcc gcc agc      504
 Asp Gln Pro Ala Glu Pro Asn Phe Ser Thr Leu Leu Thr Ala Ala Ser
     110                 115                 120

 tac ctc cag ctg ccc gag ttg gca gcc ctc tgc cgc cgc aaa ctc aag      552
 Tyr Leu Gln Leu Pro Glu Leu Ala Ala Leu Cys Arg Arg Lys Leu Lys
 125                 130                 135                 140

 cga gcc ggc aag ccc ttt ggc tct ggg agg gcg ggg tcc act ggc atg      600
 Arg Ala Gly Lys Pro Phe Gly Ser Gly Arg Ala Gly Ser Thr Gly Met
                 145                 150                 155

 ggg cgg ccc ccc cgc agc cag cgg ctg tcc acg gcc tct gtc atc caa      648
 Gly Arg Pro Pro Arg Ser Gln Arg Leu Ser Thr Ala Ser Val Ile Gln
             160                 165                 170

 gct cgg tat cag ggg ctc gtg gat ggg cgc aag ggg gcc cac gcc ccc      696
 Ala Arg Tyr Gln Gly Leu Val Asp Gly Arg Lys Gly Ala His Ala Pro
         175                 180                 185

 cag gag ctc ccc caa gcc aaa ggc tca gac gat gaa ctc ttt ctt ggt      744
 Gln Glu Leu Pro Gln Ala Lys Gly Ser Asp Asp Glu Leu Phe Leu Gly
     190                 195                 200

 ggc tct aac cag gat agc gtg caa ggt ctg ggc cgg gct gtc tgc cca      792
 Gly Ser Asn Gln Asp Ser Val Gln Gly Leu Gly Arg Ala Val Cys Pro
 205                 210                 215                 220

 gct ggc ggg gag gcg ggt ctg ggg ggc tgc agc agc agc acc aac ggg      840
 Ala Gly Gly Glu Ala Gly Leu Gly Gly Cys Ser Ser Ser Thr Asn Gly
                 225                 230                 235

 agc agc ggg ggc tgc gag cag gag ctg ggc ttg gac ctg tcc aag aaa      888
 Ser Ser Gly Gly Cys Glu Gln Glu Leu Gly Leu Asp Leu Ser Lys Lys
             240                 245                 250

 agc cca ccc ttg ccc cct gcc acc cca ggt ccc cac ctc act ccc gat      936
 Ser Pro Pro Leu Pro Pro Ala Thr Pro Gly Pro His Leu Thr Pro Asp
         255                 260                 265

 gac gca gcc cag ctg agc gac agc caa cat ggc tcg ccc cct gcg gcc      984
 Asp Ala Ala Gln Leu Ser Asp Ser Gln His Gly Ser Pro Pro Ala Ala
     270                 275                 280

 tct gct cct ccc gtt gcc aac agt gcc tct tat tct gag ctg ggg ggc     1032
 Ser Ala Pro Pro Val Ala Asn Ser Ala Ser Tyr Ser Glu Leu Gly Gly
 285                 290                 295                 300

 acc cct gat gag ccc atg gat ctg gag ggg gcc gag gac aac cac ctg     1080
 Thr Pro Asp Glu Pro Met Asp Leu Glu Gly Ala Glu Asp Asn His Leu
                 305                 310                 315

 agc ctg ctg gag gcg cct ggt ggg cag cct cgg aag agc ctc cgg cac     1128
 Ser Leu Leu Glu Ala Pro Gly Gly Gln Pro Arg Lys Ser Leu Arg His
             320                 325                 330

 tcc act cgg aag aag gag tgg ggc aag aag gag cct gtg gct ggc tcc     1176
 Ser Thr Arg Lys Lys Glu Trp Gly Lys Lys Glu Pro Val Ala Gly Ser
         335                 340                 345

 ccc ttt gag cgg aga gaa gca ggg ccc aag ggt ccc tgc ccg gga gag     1224
 Pro Phe Glu Arg Arg Glu Ala Gly Pro Lys Gly Pro Cys Pro Gly Glu
     350                 355                 360

 gag ggt gag ggg gtc ggg gac agg gtt ccc aat ggc atc ctg gct agt     1272
 Glu Gly Glu Gly Val Gly Asp Arg Val Pro Asn Gly Ile Leu Ala Ser
 365                 370                 375                 380

 ggg gct ggc cct agc ggg ccc tat ggg gag ccc ccc tac ccc tgc aag     1320
 Gly Ala Gly Pro Ser Gly Pro Tyr Gly Glu Pro Pro Tyr Pro Cys Lys
                 385                 390                 395

 gag gag gag gag aac ggc aag gat gca agt gaa gac agt gcg cag agc     1368
 Glu Glu Glu Glu Asn Gly Lys Asp Ala Ser Glu Asp Ser Ala Gln Ser
             400                 405                 410

 ggg agc gag ggg ggc agc ggc cat gcc agc gcc cac tac atg tac cgg     1416
 Gly Ser Glu Gly Gly Ser Gly His Ala Ser Ala His Tyr Met Tyr Arg
         415                 420                 425

 cag gag ggc tac gag acg gtg tcc tac ggg gac aac ttg tat gtg tgc     1464
 Gln Glu Gly Tyr Glu Thr Val Ser Tyr Gly Asp Asn Leu Tyr Val Cys
     430                 435                 440

 att ccc tgc gcc aag ggc ttc ccc agc tct gag cag ctc aat gcg cac     1512
 Ile Pro Cys Ala Lys Gly Phe Pro Ser Ser Glu Gln Leu Asn Ala His
 445                 450                 455                 460

 gtg gag act cac acg gag gaa gag ctg ttc atc aag gaa gag ggg gcc     1560
 Val Glu Thr His Thr Glu Glu Glu Leu Phe Ile Lys Glu Glu Gly Ala
                 465                 470                 475

 tac gag aca ggc agt ggg ggt gcc gag gag gag gcc gag gac ctg tca     1608
 Tyr Glu Thr Gly Ser Gly Gly Ala Glu Glu Glu Ala Glu Asp Leu Ser
             480                 485                 490

 gca ccc agt gcg gcc tac acg gct gag ccc cgg ccc ttc aag tgt tcg     1656
 Ala Pro Ser Ala Ala Tyr Thr Ala Glu Pro Arg Pro Phe Lys Cys Ser
         495                 500                 505

 gtc tgc gag aag acc tac aag gac cca gcc acg ctg cgg cag cac gag     1704
 Val Cys Glu Lys Thr Tyr Lys Asp Pro Ala Thr Leu Arg Gln His Glu
     510                 515                 520

 aag acg cac tgg ctg aca cgg ccc ttc ccc tgc aac atc tgt ggc aaa     1752
 Lys Thr His Trp Leu Thr Arg Pro Phe Pro Cys Asn Ile Cys Gly Lys
 525                 530                 535                 540

 atg ttc acg cag cgc ggc acc atg acg cgt cac atg cgg agc cac ctg     1800
 Met Phe Thr Gln Arg Gly Thr Met Thr Arg His Met Arg Ser His Leu
                 545                 550                 555

 ggc ctg aag ccc ttc gcc tgc gat gag tgt ggc atg cgc ttc acc cgt     1848
 Gly Leu Lys Pro Phe Ala Cys Asp Glu Cys Gly Met Arg Phe Thr Arg
             560                 565                 570

 cag tac cgc ctc acg gag cac atg cgt gtg cac tcg ggc gag aaa cct     1896
 Gln Tyr Arg Leu Thr Glu His Met Arg Val His Ser Gly Glu Lys Pro
         575                 580                 585

 tac gag tgc cag ctg tgc ggg ggc aag ttc acc cag cag cgc aac ctc     1944
 Tyr Glu Cys Gln Leu Cys Gly Gly Lys Phe Thr Gln Gln Arg Asn Leu
     590                 595                 600

 atc agc cac ctg cgc atg cac acc tcc ccc tcc tag aagc caaaagcacc     1994
 Ile Ser His Leu Arg Met His Thr Ser Pro Ser 
 605                 610                 615

 gcgggcggcc catcatgcca acctttgcat ccccgggaac ccatggaagg gagaagcgag   2054

 gtgatagcag caggcagggg gcaagcaccc tgggtccaag ttggaaggct cctgggtggc   2114

 ccctctggcc cccactgccc acacccagag ctttaatgga cagtccgtac caagcagagc   2174

 cgagaggagg gaagccaggg gtcccagccc gtctacctcc ccatcccacc cagggccgca   2234

 tgctccccgc ggggagccac cgcagggcct gtgggctggg tcacgtgggt ctcgctggga   2294

 cctggtccct ttgttgcagg cggcttggag aaagggcagt gggacgctgg ccacggccag   2354

 ggtggtgtcg ggagcaggcc tcaccccgct ggccgtgtct gtgtgtgtgc acgtgtgctt   2414

 gtgtctgtgc gggcgcgtgc agccctggtt ctgcagggaa caggtgctgg gggtgcagat   2474

 ccctccctcc ttgagccagg gtggcactgt tcactggcgc tgggacagtc agggtgaccc   2534

 caccgcctac ctctctacaa ctaaagagcc ctctgggcct gtgttgctgt tattcctact   2594

 gatctgttcc tctgtttttc tttttgattt ttgtttttta aaccaaaaca gacaatagct   2654

 tattttcttt ccgccccctc cggggctgag cctgggtctg aagactgaat gtaacagggg   2714

 ccgctggcac tcctgcgcgt cccccggctc tggcgctgca ggggtgtcgg cgcgccacct   2774

 ctccaggccc cagaagccct tcttgcccaa aggcttccct ggtccctgag ccctgcctcg   2834

 gctgcctcag gggagagtgc ttttcctgta gtttccaagg aatattcttt gtttagaggt   2894

 acttgttttt tattaagaga aaaaccagtg taacgttaaa aaaaaaaaaa aaag         2948




      <210> 144
      <211> 1625
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(1239)

      <400> 144
 aaggatcctt aattaaatta atcccccccc cccggtcggc ctaggtgcgc tgcgagcgcg     60

 cgcggaccgc gcacaggcgg cggagccggt atgggcccgc ctgaccctgg gcgccgcgcc    120

 gcacgagcac cagcctagag ccaggactga agcttcaag   atg gct gac cag gac     174
                                              Met Ala Asp Gln Asp
                                                1               5

 cct gcg ggc atc agc ccc ctc cag caa atg gtg gcc tca ggc acc ggg      222
 Pro Ala Gly Ile Ser Pro Leu Gln Gln Met Val Ala Ser Gly Thr Gly
                  10                  15                  20

 gct gtg gtt acc tct ctc ttc atg aca ccc ctg gac gtg gtg aag gtt      270
 Ala Val Val Thr Ser Leu Phe Met Thr Pro Leu Asp Val Val Lys Val
              25                  30                  35

 cgc ctg cag tct cag cgg ccc tcc atg gcc agc gag ctg atg cct tcc      318
 Arg Leu Gln Ser Gln Arg Pro Ser Met Ala Ser Glu Leu Met Pro Ser
          40                  45                  50

 tcc aga ctg tgg agc ctc tcc tat acc aaa ttg ccc tcc tct ctc caa      366
 Ser Arg Leu Trp Ser Leu Ser Tyr Thr Lys Leu Pro Ser Ser Leu Gln
      55                  60                  65

 tcc aca ggg aag tgc ctc ctg tat tgc aat ggt gtc ctg gag cct ctg      414
 Ser Thr Gly Lys Cys Leu Leu Tyr Cys Asn Gly Val Leu Glu Pro Leu
  70                  75                  80                  85

 tac ctg tgc cca aat ggt gcc cgc tgt gcc acc tgg ttt caa gac cct      462
 Tyr Leu Cys Pro Asn Gly Ala Arg Cys Ala Thr Trp Phe Gln Asp Pro
                  90                  95                 100

 acc cgc ttc act ggc acc atg gat gcc ttc gtg aag atc gtg agg cac      510
 Thr Arg Phe Thr Gly Thr Met Asp Ala Phe Val Lys Ile Val Arg His
             105                 110                 115

 gag ggc acc agg acc ctc tgg agc ggc ctc ccc gcc acc ctg gtg atg      558
 Glu Gly Thr Arg Thr Leu Trp Ser Gly Leu Pro Ala Thr Leu Val Met
         120                 125                 130

 act gtg cca gct acc gcc atc tac ttc act gcc tat gac caa ctg aag      606
 Thr Val Pro Ala Thr Ala Ile Tyr Phe Thr Ala Tyr Asp Gln Leu Lys
     135                 140                 145

 gcc ttc ctg tgt ggt cga gcc ctg acc tct gac ctc tac gca ccc atg      654
 Ala Phe Leu Cys Gly Arg Ala Leu Thr Ser Asp Leu Tyr Ala Pro Met
 150                 155                 160                 165

 gtg gct ggc gcg ctg gcc cgc ctg ggc acc gtg act gtg atc agc ccc      702
 Val Ala Gly Ala Leu Ala Arg Leu Gly Thr Val Thr Val Ile Ser Pro
                 170                 175                 180

 ctg gag ctt atg cgg aca aag ctg cag gct cag cat gtg tcg tac cgg      750
 Leu Glu Leu Met Arg Thr Lys Leu Gln Ala Gln His Val Ser Tyr Arg
             185                 190                 195

 gag ctg ggt gcc tgt gtt cga act gca gtg gct cag ggt ggc tgg cgc      798
 Glu Leu Gly Ala Cys Val Arg Thr Ala Val Ala Gln Gly Gly Trp Arg
         200                 205                 210

 tca ctg tgg ctg ggc tgg ggc ccc act gcc ctt cga gat gtg ccc ttc      846
 Ser Leu Trp Leu Gly Trp Gly Pro Thr Ala Leu Arg Asp Val Pro Phe
     215                 220                 225

 tca gcc ctg tac tgg ttc aac tat gag ctg gtg aag agc tgg ctc aat      894
 Ser Ala Leu Tyr Trp Phe Asn Tyr Glu Leu Val Lys Ser Trp Leu Asn
 230                 235                 240                 245

 ggg ttc agg ccg aag gac cag act tct gtg ggc atg agc ttt gtg gct      942
 Gly Phe Arg Pro Lys Asp Gln Thr Ser Val Gly Met Ser Phe Val Ala
                 250                 255                 260

 ggt ggc atc tca ggg acg gtg gct gca gtg ctg act cta ccc ttt gac      990
 Gly Gly Ile Ser Gly Thr Val Ala Ala Val Leu Thr Leu Pro Phe Asp
             265                 270                 275

 gtg gta aag acc caa cgc cag gtc gct ctg gga gcg atg gag gct gtg     1038
 Val Val Lys Thr Gln Arg Gln Val Ala Leu Gly Ala Met Glu Ala Val
         280                 285                 290

 aga gtg aac ccc ctg cat gtg gac tcc acc tgg ctg ctg ctg cgg agg     1086
 Arg Val Asn Pro Leu His Val Asp Ser Thr Trp Leu Leu Leu Arg Arg
     295                 300                 305

 atc cgg gcc gag tcg ggc acc aag gga ctc ttt gca ggc ttc ctt cct     1134
 Ile Arg Ala Glu Ser Gly Thr Lys Gly Leu Phe Ala Gly Phe Leu Pro
 310                 315                 320                 325

 cgg atc atc aag gct gcc ccc tcc tgt gcc atc atg atc agc acc tat     1182
 Arg Ile Ile Lys Ala Ala Pro Ser Cys Ala Ile Met Ile Ser Thr Tyr
                 330                 335                 340

 gag ttc ggc aaa agc ttc ttc cag agg ctg aac cag gac cgg ctt ctg     1230
 Glu Phe Gly Lys Ser Phe Phe Gln Arg Leu Asn Gln Asp Arg Leu Leu
             345                 350                 355

 ggc ggc tga aaggggc aaggaggcaa ggaccccgtc tctcccacgg atggggagag     1286
 Gly Gly 


 ggcaggagga gacccagcca agtgcctttt cctcagcact gagggagggg gcttgtttcc   1346

 cttccctccc ggcgacaagc tccagggcag ggctgtccct ttgggcggcc cagcacttcc   1406

 tcagacacaa ctttttcctg ctgctccagt ggtggggatc atcacttacc caccccccaa   1466

 gttcaagacc aaattttcca gctgccccct ttgtgtttcc ctgtgtttgc tgtagctggg   1526

 catgtctcca ggaaccaaaa agccctcagc ctggggtagt ctccctgacc cttgttaatt   1586

 ccttaagttt aaagatgatg aacttcaaaa aaaaaaaaa                          1625




      <210> 145
      <211> 2717
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(2688)

      <400> 145
 tccccccctc ccccattccg ctaggtacga ggctgggtgt tgcacgtgtc ttagggtagc     60

 gcgcgcctgt ctctcttcgg gtctcgggcc cttgggcgca gcggggcgcg cgcc  atg     117
                                                              Met
                                                                1

 gcg aag gcg aag aag gtc ggg gcg cga agg aag gcc tcc ggg gcg ccg      165
 Ala Lys Ala Lys Lys Val Gly Ala Arg Arg Lys Ala Ser Gly Ala Pro
               5                  10                  15

 gcg gga gcg cga ggg ggc ccg gcg aag gcc aac tcc aat ccg ttc gag      213
 Ala Gly Ala Arg Gly Gly Pro Ala Lys Ala Asn Ser Asn Pro Phe Glu
          20                  25                  30

 gtg aaa gtt aac agg cag aag ttc cag atc ctg ggc cgg aag acg cgc      261
 Val Lys Val Asn Arg Gln Lys Phe Gln Ile Leu Gly Arg Lys Thr Arg
      35                  40                  45

 cac gac gtg gga ctg ccc ggg gtg tct cgc gca cgg gcc ctc agg aag      309
 His Asp Val Gly Leu Pro Gly Val Ser Arg Ala Arg Ala Leu Arg Lys
  50                  55                  60                  65

 cgt aca cag act tta cta aaa gag tac aaa gaa agg gat aaa tcc aat      357
 Arg Thr Gln Thr Leu Leu Lys Glu Tyr Lys Glu Arg Asp Lys Ser Asn
                  70                  75                  80

 gta ttc aga gat aaa cgc ttc gga gaa tac aac agc aac atg agc ccc      405
 Val Phe Arg Asp Lys Arg Phe Gly Glu Tyr Asn Ser Asn Met Ser Pro
              85                  90                  95

 gag gag aag atg atg aag agg ttt gct ctg gaa cag cag cga cat cat      453
 Glu Glu Lys Met Met Lys Arg Phe Ala Leu Glu Gln Gln Arg His His
         100                 105                 110

 gag aaa aaa agc atc tac aat cta aat gaa gat gaa gaa ttg act cat      501
 Glu Lys Lys Ser Ile Tyr Asn Leu Asn Glu Asp Glu Glu Leu Thr His
     115                 120                 125

 tat ggc cag tct ttg gca gac atc gag aag cat aat gac att gtg gac      549
 Tyr Gly Gln Ser Leu Ala Asp Ile Glu Lys His Asn Asp Ile Val Asp
 130                 135                 140                 145

 agt gac agc gat gct gag gat cga gga acg ttg tct gct gag ctg act      597
 Ser Asp Ser Asp Ala Glu Asp Arg Gly Thr Leu Ser Ala Glu Leu Thr
                 150                 155                 160

 gct gcc cac ttt gga gga ggc ggt ggg ctc ctt cac aag aag act caa      645
 Ala Ala His Phe Gly Gly Gly Gly Gly Leu Leu His Lys Lys Thr Gln
             165                 170                 175

 cag gaa ggc gag gag cgg gag aaa ccg aag tcc cgg aaa gag ctg att      693
 Gln Glu Gly Glu Glu Arg Glu Lys Pro Lys Ser Arg Lys Glu Leu Ile
         180                 185                 190

 gaa gag ctc att gcc aag tca aaa caa gag aag agg gag aga caa gct      741
 Glu Glu Leu Ile Ala Lys Ser Lys Gln Glu Lys Arg Glu Arg Gln Ala
     195                 200                 205

 caa cga gaa gat gcc ctc gag ctc acg gag aag cta gac caa gac tgg      789
 Gln Arg Glu Asp Ala Leu Glu Leu Thr Glu Lys Leu Asp Gln Asp Trp
 210                 215                 220                 225

 aaa gaa att cag act ctc ctg tcc cac aaa act ccc aag tca gag aac      837
 Lys Glu Ile Gln Thr Leu Leu Ser His Lys Thr Pro Lys Ser Glu Asn
                 230                 235                 240

 aga gac aaa aag gaa aaa ccc aag ccc gat gca tat gac atg atg gtt      885
 Arg Asp Lys Lys Glu Lys Pro Lys Pro Asp Ala Tyr Asp Met Met Val
             245                 250                 255

 cgc gag ctt ggc ttt gaa atg aag gcg cag ccc tct aac agg atg aag      933
 Arg Glu Leu Gly Phe Glu Met Lys Ala Gln Pro Ser Asn Arg Met Lys
         260                 265                 270

 acg gag gca gaa ttg gca aag gaa gag cag gag cac ctc agg aag ctg      981
 Thr Glu Ala Glu Leu Ala Lys Glu Glu Gln Glu His Leu Arg Lys Leu
     275                 280                 285

 gag gct gag aga ctt cga aga atg ctt gga aag gat gag gat gaa aat     1029
 Glu Ala Glu Arg Leu Arg Arg Met Leu Gly Lys Asp Glu Asp Glu Asn
 290                 295                 300                 305

 gtt aag aaa cca aaa cat atg tca gca gat gat ctg aat gat ggc ttc     1077
 Val Lys Lys Pro Lys His Met Ser Ala Asp Asp Leu Asn Asp Gly Phe
                 310                 315                 320

 gtg cta gat aaa gat gac agg cgt ttg ctt tcc tac aaa gat gga aag     1125
 Val Leu Asp Lys Asp Asp Arg Arg Leu Leu Ser Tyr Lys Asp Gly Lys
             325                 330                 335

 atg aat gtc gag gaa gat gtc cag gaa gag caa agc aag gaa gcc agt     1173
 Met Asn Val Glu Glu Asp Val Gln Glu Glu Gln Ser Lys Glu Ala Ser
         340                 345                 350

 gac cct gag agc aac gag gaa gaa ggt gac agt tca ggc ggg gag gac     1221
 Asp Pro Glu Ser Asn Glu Glu Glu Gly Asp Ser Ser Gly Gly Glu Asp
     355                 360                 365

 aca gag gag agc gac agc cca gat agc cac ttg gac ctg gaa tcc aac     1269
 Thr Glu Glu Ser Asp Ser Pro Asp Ser His Leu Asp Leu Glu Ser Asn
 370                 375                 380                 385

 gtg gag agt gag gaa gaa aac gag aag cca gca aaa gag cag agg cag     1317
 Val Glu Ser Glu Glu Glu Asn Glu Lys Pro Ala Lys Glu Gln Arg Gln
                 390                 395                 400

 act cct ggg aaa ggg ttg ata agc ggc aag gaa aga gct gga aaa gct     1365
 Thr Pro Gly Lys Gly Leu Ile Ser Gly Lys Glu Arg Ala Gly Lys Ala
             405                 410                 415

 acc aga gac gag ctg ccc tac acg ttc gca gcc cct gaa tcc tat gag     1413
 Thr Arg Asp Glu Leu Pro Tyr Thr Phe Ala Ala Pro Glu Ser Tyr Glu
         420                 425                 430

 gaa ctg aga tct ctg ttg tta gga aga tcg atg gaa gag cag ctt ttg     1461
 Glu Leu Arg Ser Leu Leu Leu Gly Arg Ser Met Glu Glu Gln Leu Leu
     435                 440                 445

 gtg gtg gag aga att cag aag tgc aac cac ccg agt ctc gca gaa gga     1509
 Val Val Glu Arg Ile Gln Lys Cys Asn His Pro Ser Leu Ala Glu Gly
 450                 455                 460                 465

 aac aaa gca aaa tta gaa aaa ctg ttt ggc ttt ctt ttg gaa tac gtt     1557
 Asn Lys Ala Lys Leu Glu Lys Leu Phe Gly Phe Leu Leu Glu Tyr Val
                 470                 475                 480

 ggc gat ttg gct aca gat gac cca cca gac ctc aca gtc att gat aag     1605
 Gly Asp Leu Ala Thr Asp Asp Pro Pro Asp Leu Thr Val Ile Asp Lys
             485                 490                 495

 ttg gtt gtg cac tta tat cat ctt tgc cag atg ttt cct gaa tct gca     1653
 Leu Val Val His Leu Tyr His Leu Cys Gln Met Phe Pro Glu Ser Ala
         500                 505                 510

 agt gac gct atc aaa ttt gtt ctc cga gat gcg atg cat gag atg gaa     1701
 Ser Asp Ala Ile Lys Phe Val Leu Arg Asp Ala Met His Glu Met Glu
     515                 520                 525

 gaa atg att gag acc aaa ggc cgg gcg gca ttg cca ggg ttg gat gtg     1749
 Glu Met Ile Glu Thr Lys Gly Arg Ala Ala Leu Pro Gly Leu Asp Val
 530                 535                 540                 545

 ctc att tat ttg aaa atc act ggg ctg cta ttt cca act tcc gac ttc     1797
 Leu Ile Tyr Leu Lys Ile Thr Gly Leu Leu Phe Pro Thr Ser Asp Phe
                 550                 555                 560

 tgg cac cca gtg gtg acc cct gcc ctc gtg tgc ctc agt cag ctg ctc     1845
 Trp His Pro Val Val Thr Pro Ala Leu Val Cys Leu Ser Gln Leu Leu
             565                 570                 575

 acc aag tgc ccc atc ctg tcc ctc cag gac gtg gtg aag ggc ctg ttc     1893
 Thr Lys Cys Pro Ile Leu Ser Leu Gln Asp Val Val Lys Gly Leu Phe
         580                 585                 590

 gtg tgc tgc ctg ttc ctg gag tat gtg gct ttg tcc cag agg ttt ata     1941
 Val Cys Cys Leu Phe Leu Glu Tyr Val Ala Leu Ser Gln Arg Phe Ile
     595                 600                 605

 cct gag ctt att aat ttt ctt ctt ggg att ctt tac ata gca act cca     1989
 Pro Glu Leu Ile Asn Phe Leu Leu Gly Ile Leu Tyr Ile Ala Thr Pro
 610                 615                 620                 625

 aac aaa gca agc caa ggt tcc act ctg gtg cac cct ttc aga gcg ctt     2037
 Asn Lys Ala Ser Gln Gly Ser Thr Leu Val His Pro Phe Arg Ala Leu
                 630                 635                 640

 ggg aag aac tcg gaa ctg ctc gtg gtg tct gct aga gag gat gtg gcc     2085
 Gly Lys Asn Ser Glu Leu Leu Val Val Ser Ala Arg Glu Asp Val Ala
             645                 650                 655

 acg tgg cag cag agc agc ctc tcc ctc cgc tgg gcg agt aga ctg agg     2133
 Thr Trp Gln Gln Ser Ser Leu Ser Leu Arg Trp Ala Ser Arg Leu Arg
         660                 665                 670

 gcc cca act tcg aca gag gcc aat cac atc cga ctg tcc tgc ctg gct     2181
 Ala Pro Thr Ser Thr Glu Ala Asn His Ile Arg Leu Ser Cys Leu Ala
     675                 680                 685

 gtg ggc ctg gcc ctg ctg aag cgc tgc gtg ctc atg tac ggg tcc ctg     2229
 Val Gly Leu Ala Leu Leu Lys Arg Cys Val Leu Met Tyr Gly Ser Leu
 690                 695                 700                 705

 cca tcc ttc cac gcc atc atg ggg cct ctc cga gcc ctc ctc acg gat     2277
 Pro Ser Phe His Ala Ile Met Gly Pro Leu Arg Ala Leu Leu Thr Asp
                 710                 715                 720

 cac ctg gcg gac tgc agc cac ccg cag gag ctc cag gag ctg tgt cag     2325
 His Leu Ala Asp Cys Ser His Pro Gln Glu Leu Gln Glu Leu Cys Gln
             725                 730                 735

 agc aca ctg acc gaa atg gaa agc cag aag cag ctc tgc cgg ccg ctg     2373
 Ser Thr Leu Thr Glu Met Glu Ser Gln Lys Gln Leu Cys Arg Pro Leu
         740                 745                 750

 acc tgt gag aag agc aag cct gtc cca ctg aag ctt ttc aca ccc cgg     2421
 Thr Cys Glu Lys Ser Lys Pro Val Pro Leu Lys Leu Phe Thr Pro Arg
     755                 760                 765

 ctg gtc aaa gtc ctc gag ttt gga aga aaa caa ggc agt agt aag gag     2469
 Leu Val Lys Val Leu Glu Phe Gly Arg Lys Gln Gly Ser Ser Lys Glu
 770                 775                 780                 785

 gaa cag gaa agg aag agg ctg atc cac aaa cac aag cgt gaa ttt aaa     2517
 Glu Gln Glu Arg Lys Arg Leu Ile His Lys His Lys Arg Glu Phe Lys
                 790                 795                 800

 ggg gcc gtt cga gaa atc cgc aag gac aat cag ttc ctg gcg agg atg     2565
 Gly Ala Val Arg Glu Ile Arg Lys Asp Asn Gln Phe Leu Ala Arg Met
             805                 810                 815

 caa ctc tca gaa atc atg gaa cgg gat gcg gaa aga aag cgg aaa gta     2613
 Gln Leu Ser Glu Ile Met Glu Arg Asp Ala Glu Arg Lys Arg Lys Val
         820                 825                 830

 aag cag ctt ttt aac agc ctg gct aca cag gaa ggc gaa tgg aag gct     2661
 Lys Gln Leu Phe Asn Ser Leu Ala Thr Gln Glu Gly Glu Trp Lys Ala
     835                 840                 845

 ctg aag agg aaa aag ttc aaa aaa taa attac attttataaa taaaaaaaaa     2713
 Leu Lys Arg Lys Lys Phe Lys Lys 
 850                 855

 aaaa                                                                2717




      <210> 146
      <211> 4432
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1129)..(2817)

      <400> 146
 gacgggaggc tgatgcaggt ttcccgcgac ctgacagcat ggagtgggga cggcgggtgt     60

 tctgtgttga gatgccagct gaaggacgtg gtgtttttac agatgcctgc tctgtgcctg    120

 tatctgagat catcgccgtt gaggaaacag acgttcacgg gaaacatcaa ggcagtggaa    180

 aatggcagaa aatggaaaag ccttacgctt ttacagttca ctgtgtaaag agagcacgac    240

 ggcaccgctg gaagtgggcg caggtgactt tctggtgtcc agaggagcag ctgtgtcact    300

 tgtggctgca gaccctgcgg gagatgctgg agaagctgag tacgtgtgtg tttggactga    360

 gagacaggat ggccgtggtg gcatgcgcat gcctgattgg gtgatcttcc tgaagtgtct    420

 ccccgtttcg tgcagctggc cataccccag gtggacatga tgagtcaggc tgacttaatt    480

 tctcatgagc agaccatccc agtgaatgca aagggcatgg gctccacagc ctggaccctg    540

 gcatggagtc cagccccctg ctcaccggcc aggaggcctg ggggcgggtc acttaccctt    600

 ctgagcctca gtttctcttt ctggaagcgg agatggtaat agcttttaca ttcgaggtga    660

 atacttcctg ccctggctgt cagccgccag ccagccctga ttcggagact gtttaccccc    720

 gagtggatga tggcagcctg gccaaggagc atccggtgcc cacctataca agaggccact    780

 ccgtcgagtg gacggaggta gacaccggct ctcagcagca gcgacgtcgt actggctctg    840

 tgctaggctc catccgggca tctgtctctc ggctgtcctc tgggggctgt gtccacatca    900

 gccagaccct gagtggggag tacagccctc caagtgcctc tggctgctgc ctggggacag    960

 aagtccctcc agagagtttg gacttgaatc ttgagctctc agccactctg ttctgcgatc   1020

 actatcctcg tttcacgtgt gagagaaaac ggaggctcca acaggactgt cctggggcct   1080

 tcactgcatg gcctgaacag gggctgggct cccagggagg aatgattc atg gct ggt    1137
                                                      Met Ala Gly
                                                        1

 tcc cgc cct ata gac aag aca gtc aca agg agc tgg cag gcc tgg cgg     1185
 Ser Arg Pro Ile Asp Lys Thr Val Thr Arg Ser Trp Gln Ala Trp Arg
       5                  10                  15

 acg agc ccg gcg gcg gag atg ggg gcg acg ggg gcg gcg gag ccg ctg     1233
 Thr Ser Pro Ala Ala Glu Met Gly Ala Thr Gly Ala Ala Glu Pro Leu
  20                  25                  30                  35

 caa tcc gtg ctg tgg gtg aag cag cag cgc tgc gcc gtg agc ctg gag     1281
 Gln Ser Val Leu Trp Val Lys Gln Gln Arg Cys Ala Val Ser Leu Glu
                  40                  45                  50

 ccc gcg cgg gct ctg ctg cgc tgg tgg cgg agc ccg ggg ccc gga gcc     1329
 Pro Ala Arg Ala Leu Leu Arg Trp Trp Arg Ser Pro Gly Pro Gly Ala
              55                  60                  65

 ggc gcc ccc ggc gcg gat gcc tgc tct gtg cct gta tct gag atc atc     1377
 Gly Ala Pro Gly Ala Asp Ala Cys Ser Val Pro Val Ser Glu Ile Ile
          70                  75                  80

 gcc gtt gag gaa aca gac gtt cac ggg aaa cat caa ggc agt gga aaa     1425
 Ala Val Glu Glu Thr Asp Val His Gly Lys His Gln Gly Ser Gly Lys
      85                  90                  95

 tgg cag aaa atg gaa aag cct tac gct ttt aca gtt cac tgt gta aag     1473
 Trp Gln Lys Met Glu Lys Pro Tyr Ala Phe Thr Val His Cys Val Lys
 100                 105                 110                 115

 aga gca cga cgg cac cgc tgg aag tgg gcg cag gtg act ttc tgg tgt     1521
 Arg Ala Arg Arg His Arg Trp Lys Trp Ala Gln Val Thr Phe Trp Cys
                 120                 125                 130

 cca gag gag cag ctg tgt cac ttg tgg ctg cag acc ctg cgg gag atg     1569
 Pro Glu Glu Gln Leu Cys His Leu Trp Leu Gln Thr Leu Arg Glu Met
             135                 140                 145

 ctg gag aag ctg acg tcc aga cca aag cat tta ctg gta ttt atc aac     1617
 Leu Glu Lys Leu Thr Ser Arg Pro Lys His Leu Leu Val Phe Ile Asn
         150                 155                 160

 ccg ttt gga gga aaa gga caa ggc aag cgg ata tat gaa aga aaa gtg     1665
 Pro Phe Gly Gly Lys Gly Gln Gly Lys Arg Ile Tyr Glu Arg Lys Val
     165                 170                 175

 gca cca ctg ttc acc tta gcc tcc atc acc act gac atc atc gtt act     1713
 Ala Pro Leu Phe Thr Leu Ala Ser Ile Thr Thr Asp Ile Ile Val Thr
 180                 185                 190                 195

 gaa cat gct aat cag gcc aag gag act ctg tat gag att aac ata gac     1761
 Glu His Ala Asn Gln Ala Lys Glu Thr Leu Tyr Glu Ile Asn Ile Asp
                 200                 205                 210

 aaa tac gac ggc atc gtc tgt gtc ggc gga gat ggt atg ttc agc gag     1809
 Lys Tyr Asp Gly Ile Val Cys Val Gly Gly Asp Gly Met Phe Ser Glu
             215                 220                 225

 gtg ctg cac ggt ctg att ggg agg acg cag agg agc gcc ggg gtc gac     1857
 Val Leu His Gly Leu Ile Gly Arg Thr Gln Arg Ser Ala Gly Val Asp
         230                 235                 240

 cag aac cac ccc cgg gct gtg ctg gtc ccc agt agc ctc cgg att gga     1905
 Gln Asn His Pro Arg Ala Val Leu Val Pro Ser Ser Leu Arg Ile Gly
     245                 250                 255

 atc att ccc gca ggg tca acg gac tgc gtg tgt tac tcc acc gtg ggc     1953
 Ile Ile Pro Ala Gly Ser Thr Asp Cys Val Cys Tyr Ser Thr Val Gly
 260                 265                 270                 275

 acc agc gac gca gaa acc tcg gcg ctg cat atc gtt gtt ggg gac tcg     2001
 Thr Ser Asp Ala Glu Thr Ser Ala Leu His Ile Val Val Gly Asp Ser
                 280                 285                 290

 ctg gcc atg gat gtg tcc tca gtc cac cac aac agc aca ctc ctt cgc     2049
 Leu Ala Met Asp Val Ser Ser Val His His Asn Ser Thr Leu Leu Arg
             295                 300                 305

 tac tcc gtg tcc ctg ctg ggc tac ggc ttc tac ggg gac atc atc aag     2097
 Tyr Ser Val Ser Leu Leu Gly Tyr Gly Phe Tyr Gly Asp Ile Ile Lys
         310                 315                 320

 gac agt gag aag aaa cgg tgg ttg ggt ctt gcc aga tac gac ttt tca     2145
 Asp Ser Glu Lys Lys Arg Trp Leu Gly Leu Ala Arg Tyr Asp Phe Ser
     325                 330                 335

 ggt tta aag acc ttc ctc tcc cac cac tgc tat gga ggg aca gtg tcc     2193
 Gly Leu Lys Thr Phe Leu Ser His His Cys Tyr Gly Gly Thr Val Ser
 340                 345                 350                 355

 ttc ctc cct gca caa cac acg gtg gga tct cca agg gat agg aag ccc     2241
 Phe Leu Pro Ala Gln His Thr Val Gly Ser Pro Arg Asp Arg Lys Pro
                 360                 365                 370

 tgc cgg gca gga tgc ttt gtt tgc agg caa agc aag cag cag ctg gag     2289
 Cys Arg Ala Gly Cys Phe Val Cys Arg Gln Ser Lys Gln Gln Leu Glu
             375                 380                 385

 gag gag cag aag aaa gca ctg tat ggt ttg gaa gct gcg gag gac gtg     2337
 Glu Glu Gln Lys Lys Ala Leu Tyr Gly Leu Glu Ala Ala Glu Asp Val
         390                 395                 400

 gag gag tgg caa gtc gtc tgt ggg aag ttt ctg gcc atc aat gcc aca     2385
 Glu Glu Trp Gln Val Val Cys Gly Lys Phe Leu Ala Ile Asn Ala Thr
     405                 410                 415

 aac atg tcc tgt gct tgt cgc cgg agc ccc agg ggc ctc tcc ccg gct     2433
 Asn Met Ser Cys Ala Cys Arg Arg Ser Pro Arg Gly Leu Ser Pro Ala
 420                 425                 430                 435

 gcc cac ttg gga gac ggg tct tct gac ctc atc ctc atc cgg aaa tgc     2481
 Ala His Leu Gly Asp Gly Ser Ser Asp Leu Ile Leu Ile Arg Lys Cys
                 440                 445                 450

 tcc agg ttc aat ttt ctg aga ttt ctc atc agg cac acc aac cag cag     2529
 Ser Arg Phe Asn Phe Leu Arg Phe Leu Ile Arg His Thr Asn Gln Gln
             455                 460                 465

 gac cag ttt gac ttc act ttt gtt gaa gtt tat cgc gtc aag aaa ttc     2577
 Asp Gln Phe Asp Phe Thr Phe Val Glu Val Tyr Arg Val Lys Lys Phe
         470                 475                 480

 cag ttt acg tcg aag cac atg gag gat gag gac agc gac ctc aag gag     2625
 Gln Phe Thr Ser Lys His Met Glu Asp Glu Asp Ser Asp Leu Lys Glu
     485                 490                 495

 ggg ggg aag aag cgc ttt ggg cac att tgc agc agc cac ccc tcc tgc     2673
 Gly Gly Lys Lys Arg Phe Gly His Ile Cys Ser Ser His Pro Ser Cys
 500                 505                 510                 515

 tgc tgc acc gtc tcc aac agc tcc tgg aac tgc gac ggg gag gtc ctg     2721
 Cys Cys Thr Val Ser Asn Ser Ser Trp Asn Cys Asp Gly Glu Val Leu
                 520                 525                 530

 cac agc cct gcc atc gag gtc aga gtc cac tgc cag ctg gtt cga ctc     2769
 His Ser Pro Ala Ile Glu Val Arg Val His Cys Gln Leu Val Arg Leu
             535                 540                 545

 ttt gca cga gga att gaa gag aat ccg aag cca gac tca cac agc tga     2817
 Phe Ala Arg Gly Ile Glu Glu Asn Pro Lys Pro Asp Ser His Ser 
         550                 555                 560

 gaagccggcg tcccgctcac aaactgggaa agtgttaaaa ctatttaaga taattattac   2877

 agaccaatta tgttgatata tacatttaaa tgtagaaatt tatttttgat agttaaatct   2937

 tgattttaga agaaaaccct tttgtcaaca attttgtgta catatttggc attttcagtt   2997

 ctgtacgcat ctgcgggttg cagcccacgc cgcttactct cagcggatgc agctgctcac   3057

 ttgggggcac tggcctctta ggttttaacg atgtcaacag tgtagtttag aaaatggccc   3117

 gttagtggct ctattgcaat aatgttaggg acattatatg atttccacgc aggtcacacc   3177

 atctgggcct gaggtagcag tgggtcactt tgatccactt tgcaggactt attctgtaac   3237

 ggtttgtggc caagttttgg gaagtggttg attctctttg ccttcatttc accttcctct   3297

 tcgtttacgg ttaggacatc gctgcttgat ccttacaata ctgtgcaact gcaatgcaac   3357

 gtggccctgc ttcaggtgat ccgcgggagg ggcctccacg ccagcgccgg gaaggctgct   3417

 ggggcctcca cacctgcctc atcacggcgg cgaggctacg acaatccggc tgggagcatg   3477

 accttggcgt ctgttctggg agcacggatg ataagctctg gaagctggca gtgtgtaaag   3537

 cactggcaag tttgttactg ttaaaatgtc aaataccaat gctttatatc gacgcgaagt   3597

 gcttaacaca gccgggcttg ggggcagtca ggaggaagct ggccatccgt ggaggagggg   3657

 ccggtcctgg actcccgcag gactcctctg atgcagggcc tgaagtctgt acacgtggtc   3717

 cagatttgtc cttgtctttt cttcacactg agttctctat atttattgaa catcttgtcc   3777

 ttttaagcca gagtagtgta aactgcgtct cggatgtctg tcttttgcct cgaagccacg   3837

 atggatcgct ggtttcctct gcagcgcgag ggctccggcg accagaggat tcttcccgga   3897

 aggcattcct gccgcgctcc ccggggcacc cctcaattgt gtactacgtc cttgtttagt   3957

 gtgtatccgt gcccacgtag atgatgtctg taacgtagtt ttgtttgaaa tatgagaata   4017

 tgcggcttaa actttgatct gtaaggagcg gggccgtggc cgtttggagc acgctgtaga   4077

 caccgttcct catgctgccg ggtgggtttt gcagaagctc ccttagtgat ttcatgttta   4137

 acaggcagca tccattttca gaatttcctg gcattgattt atattttgaa gcatacagga   4197

 aacttctcgt ttcctcgttt agccccaccc agatcaggtg aaagggcagc tttaatggtg   4257

 gtttttatgg accacattat cagagagcac tgtgcaagcc aaatggttca ataatgaatg   4317

 aaaattctgg gtgtaaagag taaatatgcc ctggctcttt ctaccaatgc ttgctcctgg   4377

 gtggaaagaa accaaagatt taagacgggc tgctcttcca gactggctgg gcctg        4432




      <210> 147
      <211> 2708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (185)..(2509)

      <400> 147
 cgtgttgttg gcagctgtgg ctaaggaggg gagaacctct gctccccgcc cgtcttctct     60

 tctgcgtttc ccgggctagg gggcgtgggg agtggtttta ggcggcgaag ccgctcggca    120

 gcaccttcct tctttgccag gcagacgccc gttgtagccg ttggggaacc gttgagaatc    180

 cgcc atg gag cca gag agg gaa ggg acc gag aga cac ccc agg aag gtc     229
      Met Glu Pro Glu Arg Glu Gly Thr Glu Arg His Pro Arg Lys Val
        1               5                  10                  15

 agg gaa agc agg cag gcc cca aat aag ctg gtc ggg gca gct gag gcg      277
 Arg Glu Ser Arg Gln Ala Pro Asn Lys Leu Val Gly Ala Ala Glu Ala
                  20                  25                  30

 atg aaa gcc ggt tgg gat ctc gag gag agt cag ccc gag gcc aag aaa      325
 Met Lys Ala Gly Trp Asp Leu Glu Glu Ser Gln Pro Glu Ala Lys Lys
              35                  40                  45

 gcc cgc tta tct acc att tta ttt act gac aac tgt gaa gta acc cat      373
 Ala Arg Leu Ser Thr Ile Leu Phe Thr Asp Asn Cys Glu Val Thr His
          50                  55                  60

 gac cag ctg tgt gaa ttg ctg aag tat gca gtt ctg ggc aaa tcc aat      421
 Asp Gln Leu Cys Glu Leu Leu Lys Tyr Ala Val Leu Gly Lys Ser Asn
      65                  70                  75

 gtt cca aaa ccc agc tgg tgc cag ctt ttt cat caa aac cac cta aac      469
 Val Pro Lys Pro Ser Trp Cys Gln Leu Phe His Gln Asn His Leu Asn
  80                  85                  90                  95

 aac gta gtg gtt ttt gtt ctg cag gga atg agt cag cta cac ttt tac      517
 Asn Val Val Val Phe Val Leu Gln Gly Met Ser Gln Leu His Phe Tyr
                 100                 105                 110

 agg ttc tat ttg gag ttt gga tgt ctt cga aaa gca ttc aga cat aaa      565
 Arg Phe Tyr Leu Glu Phe Gly Cys Leu Arg Lys Ala Phe Arg His Lys
             115                 120                 125

 ttc cgc ttg cct cca cca tca tct gat ttt cta gct gat gtt gtt ggg      613
 Phe Arg Leu Pro Pro Pro Ser Ser Asp Phe Leu Ala Asp Val Val Gly
         130                 135                 140

 cta caa act gaa caa aga gct gga gat ctg ccc aag aca atg gaa ggg      661
 Leu Gln Thr Glu Gln Arg Ala Gly Asp Leu Pro Lys Thr Met Glu Gly
     145                 150                 155

 cct tta cct tct aat gca aaa gcc gcc atc aac ctt cag gat gat ccc      709
 Pro Leu Pro Ser Asn Ala Lys Ala Ala Ile Asn Leu Gln Asp Asp Pro
 160                 165                 170                 175

 atc att caa aag tat ggc tct aag aaa gtg ggc ttg acc aga tgc ctt      757
 Ile Ile Gln Lys Tyr Gly Ser Lys Lys Val Gly Leu Thr Arg Cys Leu
                 180                 185                 190

 ctg aca aag gag gaa atg aga acg ttt cac ttt cca tta caa ggt ttt      805
 Leu Thr Lys Glu Glu Met Arg Thr Phe His Phe Pro Leu Gln Gly Phe
             195                 200                 205

 cct gat tgt gaa aac ttt tta ctt acc aaa tgt aat ggt tct ata gca      853
 Pro Asp Cys Glu Asn Phe Leu Leu Thr Lys Cys Asn Gly Ser Ile Ala
         210                 215                 220

 gac aat agt cct ctc ttt gga ctt gac tgt gaa atg tgc ctc aca tcc      901
 Asp Asn Ser Pro Leu Phe Gly Leu Asp Cys Glu Met Cys Leu Thr Ser
     225                 230                 235

 aag ggg aga gag cta aca cgc atc tca ctg gtt gct gaa gga ggc tgc      949
 Lys Gly Arg Glu Leu Thr Arg Ile Ser Leu Val Ala Glu Gly Gly Cys
 240                 245                 250                 255

 tgt gtt atg gat gaa ctg gtc aaa cct gaa aac aag att ctg gac tac      997
 Cys Val Met Asp Glu Leu Val Lys Pro Glu Asn Lys Ile Leu Asp Tyr
                 260                 265                 270

 ctc acc agc ttt tcg gga atc acg aag aag att ctt aac cca gtg acg     1045
 Leu Thr Ser Phe Ser Gly Ile Thr Lys Lys Ile Leu Asn Pro Val Thr
             275                 280                 285

 acc aaa ctc aaa gat gta cag agg cag tta aaa gca ctg ctt cct cct     1093
 Thr Lys Leu Lys Asp Val Gln Arg Gln Leu Lys Ala Leu Leu Pro Pro
         290                 295                 300

 gat gct gtg tta gtg ggc cac tcc tta gat ttg gat ctc aga gca ctg     1141
 Asp Ala Val Leu Val Gly His Ser Leu Asp Leu Asp Leu Arg Ala Leu
     305                 310                 315

 aaa atg ata cat cca tat gtt att gat aca tcg ttg ctt tat gtc aga     1189
 Lys Met Ile His Pro Tyr Val Ile Asp Thr Ser Leu Leu Tyr Val Arg
 320                 325                 330                 335

 gag cag ggc aga aga ttt aag ctc aag ttc tta gcc aaa gtt att ttg     1237
 Glu Gln Gly Arg Arg Phe Lys Leu Lys Phe Leu Ala Lys Val Ile Leu
                 340                 345                 350

 ggg aag gat ata cag tgt cca gac aga ctt ggt cat gat gcc aca gaa     1285
 Gly Lys Asp Ile Gln Cys Pro Asp Arg Leu Gly His Asp Ala Thr Glu
             355                 360                 365

 gat gct aga aca atc ctt gaa ttg gct cgg tat ttc ctt aag cat ggc     1333
 Asp Ala Arg Thr Ile Leu Glu Leu Ala Arg Tyr Phe Leu Lys His Gly
         370                 375                 380

 cca aaa aag att gca gaa cta aat cta gaa gca cta gct aat cac caa     1381
 Pro Lys Lys Ile Ala Glu Leu Asn Leu Glu Ala Leu Ala Asn His Gln
     385                 390                 395

 gaa ata caa gca gca ggc caa gag cct aaa aac aca gca gaa gta ctt     1429
 Glu Ile Gln Ala Ala Gly Gln Glu Pro Lys Asn Thr Ala Glu Val Leu
 400                 405                 410                 415

 cag cac cca aac aca agt gtt tta gaa tgc ttg gat tca gtg ggt cag     1477
 Gln His Pro Asn Thr Ser Val Leu Glu Cys Leu Asp Ser Val Gly Gln
                 420                 425                 430

 aag ctt ctt ttt ttg acc cgg gag aca gat gct ggt gaa ctt cca tct     1525
 Lys Leu Leu Phe Leu Thr Arg Glu Thr Asp Ala Gly Glu Leu Pro Ser
             435                 440                 445

 tcc aga aat tgt caa act att aag tgt ctt tca aat aaa gag gtt ctt     1573
 Ser Arg Asn Cys Gln Thr Ile Lys Cys Leu Ser Asn Lys Glu Val Leu
         450                 455                 460

 gag cag gcc aga gtg gaa atc ccc ctg ttt ccc ttc agc att gtt cag     1621
 Glu Gln Ala Arg Val Glu Ile Pro Leu Phe Pro Phe Ser Ile Val Gln
     465                 470                 475

 ttc tct ttt aag gcc ttt tca cct gtc ctc act gag gag atg aac aaa     1669
 Phe Ser Phe Lys Ala Phe Ser Pro Val Leu Thr Glu Glu Met Asn Lys
 480                 485                 490                 495

 agg atg agg atc aag tgg aca gag ata tca act gtc tat gct ggg cca     1717
 Arg Met Arg Ile Lys Trp Thr Glu Ile Ser Thr Val Tyr Ala Gly Pro
                 500                 505                 510

 ttt agc aaa aat tgc aat ctc agg gct ctg aag agg ctg ttt aaa agc     1765
 Phe Ser Lys Asn Cys Asn Leu Arg Ala Leu Lys Arg Leu Phe Lys Ser
             515                 520                 525

 ttt ggc cca gtc cag tca atg act ttt gtt ctt gaa acc cgt cag cct     1813
 Phe Gly Pro Val Gln Ser Met Thr Phe Val Leu Glu Thr Arg Gln Pro
         530                 535                 540

 cat ctc tgt ata cag tat gaa gtc cta gaa gct gcc cag ctg gcc ata     1861
 His Leu Cys Ile Gln Tyr Glu Val Leu Glu Ala Ala Gln Leu Ala Ile
     545                 550                 555

 gag tcc ttg gat ggt att ctg gta gat ggt atc tgc atc aag gtg cag     1909
 Glu Ser Leu Asp Gly Ile Leu Val Asp Gly Ile Cys Ile Lys Val Gln
 560                 565                 570                 575

 agg cct gtg aca gag ctc acg ctt gat tgt gac acc ctc gtg aat gag     1957
 Arg Pro Val Thr Glu Leu Thr Leu Asp Cys Asp Thr Leu Val Asn Glu
                 580                 585                 590

 ctg gaa gga gat tct gaa aac caa ggc tct ata tat ctg tct gga gtg     2005
 Leu Glu Gly Asp Ser Glu Asn Gln Gly Ser Ile Tyr Leu Ser Gly Val
             595                 600                 605

 agt gaa acc ttc aaa gaa cag cta ttg cag gag ccc cgc ctc ttt ctt     2053
 Ser Glu Thr Phe Lys Glu Gln Leu Leu Gln Glu Pro Arg Leu Phe Leu
         610                 615                 620

 ggc ctg gaa gct gtg atc ttg cct aaa gat ctt aaa agt gga aag cag     2101
 Gly Leu Glu Ala Val Ile Leu Pro Lys Asp Leu Lys Ser Gly Lys Gln
     625                 630                 635

 aaa aaa tac tgt ttc ctg aaa ttc aaa agt ttt ggc agt gcc cag cag     2149
 Lys Lys Tyr Cys Phe Leu Lys Phe Lys Ser Phe Gly Ser Ala Gln Gln
 640                 645                 650                 655

 gcc ctc aac att ctc aca ggc aag gac tgg aag ctg aaa ggc agg cat     2197
 Ala Leu Asn Ile Leu Thr Gly Lys Asp Trp Lys Leu Lys Gly Arg His
                 660                 665                 670

 gcc cta acc ccc agg cac ctc cat gcc tgg ctc aga ggc tta cca cct     2245
 Ala Leu Thr Pro Arg His Leu His Ala Trp Leu Arg Gly Leu Pro Pro
             675                 680                 685

 gaa tca aca agg ctc cca ggg ctt cgt gtt gta cct ccc ccc ttt gaa     2293
 Glu Ser Thr Arg Leu Pro Gly Leu Arg Val Val Pro Pro Pro Phe Glu
         690                 695                 700

 cag gag gcc ttg cag act ctg aaa ctg gac cac ccg aag ata gca gcc     2341
 Gln Glu Ala Leu Gln Thr Leu Lys Leu Asp His Pro Lys Ile Ala Ala
     705                 710                 715

 tgg cgc tgg agc cgg aag att gga aag ctc tac aac agc ttg tgc ccg     2389
 Trp Arg Trp Ser Arg Lys Ile Gly Lys Leu Tyr Asn Ser Leu Cys Pro
 720                 725                 730                 735

 ggc act ctc tgc ctc atc ctg ctg cca gga acc aag agc act cat ggt     2437
 Gly Thr Leu Cys Leu Ile Leu Leu Pro Gly Thr Lys Ser Thr His Gly
                 740                 745                 750

 tca ctc tct ggt cta gga ctg atg gga ata aaa gag gaa gaa gaa agc     2485
 Ser Leu Ser Gly Leu Gly Leu Met Gly Ile Lys Glu Glu Glu Glu Ser
             755                 760                 765

 gct ggc cca ggc ctg tgt tcg tga gtcggcctgc catgtttcca tgtgccattt    2539
 Ala Gly Pro Gly Leu Cys Ser 
         770

 cttacccctt gtaggcaatg gcaaagaatg tggtcaggct gtagcctccc caaccagcag   2599

 acagttttat ggaaacttgg tatagcagct aaaagagttt agtttgttta tatggcatgt   2659

 ataagttttc aataaatgcc taaagttcaa gcatagtaaa aaaaaaaaa               2708




      <210> 148
      <211> 1939
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (156)..(1847)

      <400> 148
 ttcccgggtc gacgatttcg ttaaaagttc acctttatat attcacaact acacatctta     60

 taaaaatctt ggaaggtctt gttccatgaa acttttatcc actctcaagt gggttaccct    120

 gcaatatata ctctaatatt attgtatttt ccttc   atg ttc tcc tgc gta gtt     173
                                          Met Phe Ser Cys Val Val
                                            1               5

 tct gat gaa gaa caa tca gta gta tac gtt cca gga att tct gct gaa      221
 Ser Asp Glu Glu Gln Ser Val Val Tyr Val Pro Gly Ile Ser Ala Glu
              10                  15                  20

 gga aat gtc aga tca aga cac aag ctg atg agt cca aaa gct gat gtt      269
 Gly Asn Val Arg Ser Arg His Lys Leu Met Ser Pro Lys Ala Asp Val
          25                  30                  35

 aaa ctt aag act tcc agg gtg act gat gct tca atc tcc atg gag tcc      317
 Lys Leu Lys Thr Ser Arg Val Thr Asp Ala Ser Ile Ser Met Glu Ser
      40                  45                  50

 tta aaa ggc aca gga gat tca gta gat gaa cag aat tcc tgc agg gga      365
 Leu Lys Gly Thr Gly Asp Ser Val Asp Glu Gln Asn Ser Cys Arg Gly
  55                  60                  65                  70

 gaa ata aag agt gca tca ttg aag gat tta tgt ctt gaa gac aaa aga      413
 Glu Ile Lys Ser Ala Ser Leu Lys Asp Leu Cys Leu Glu Asp Lys Arg
                  75                  80                  85

 cgc att gca aac tta att aaa gaa ctg gcc aga gta agt gag gaa aag      461
 Arg Ile Ala Asn Leu Ile Lys Glu Leu Ala Arg Val Ser Glu Glu Lys
              90                  95                 100

 gaa gtg aca gag gaa aga ctg aaa gct gag cag gag tca ttt gag aag      509
 Glu Val Thr Glu Glu Arg Leu Lys Ala Glu Gln Glu Ser Phe Glu Lys
         105                 110                 115

 aag atc agg cag ttg gaa gaa cag aat gaa ctg atc atc aaa gaa agg      557
 Lys Ile Arg Gln Leu Glu Glu Gln Asn Glu Leu Ile Ile Lys Glu Arg
     120                 125                 130

 gaa gct ctt cag cta cag tat aga gaa tgc caa gaa ctt cta agc ctg      605
 Glu Ala Leu Gln Leu Gln Tyr Arg Glu Cys Gln Glu Leu Leu Ser Leu
 135                 140                 145                 150

 tat cag aaa tat tta tca gaa caa cag gag aag ctc acc atg tct ctc      653
 Tyr Gln Lys Tyr Leu Ser Glu Gln Gln Glu Lys Leu Thr Met Ser Leu
                 155                 160                 165

 tca gaa ctt ggt gct gct aga atg cag gaa cag cag gta tcc agt aga      701
 Ser Glu Leu Gly Ala Ala Arg Met Gln Glu Gln Gln Val Ser Ser Arg
             170                 175                 180

 aaa agc act ctc cag tgt tca tct gtg gaa ctg gat ggt tcc tac ttg      749
 Lys Ser Thr Leu Gln Cys Ser Ser Val Glu Leu Asp Gly Ser Tyr Leu
         185                 190                 195

 agc ata gcc aga cca cag acc tac tat caa acc aag caa aga cct aag      797
 Ser Ile Ala Arg Pro Gln Thr Tyr Tyr Gln Thr Lys Gln Arg Pro Lys
     200                 205                 210

 tct gca gtc cag gat tca gct tca gaa tcc ctt ata gca ttt agg aat      845
 Ser Ala Val Gln Asp Ser Ala Ser Glu Ser Leu Ile Ala Phe Arg Asn
 215                 220                 225                 230

 aat tct ttg aaa cca gta acc ctt cat cat ccc aaa gat gat cta gat      893
 Asn Ser Leu Lys Pro Val Thr Leu His His Pro Lys Asp Asp Leu Asp
                 235                 240                 245

 aag ata cca tca gag acc aca aca tgt aat tgt gaa tct cca ggg aga      941
 Lys Ile Pro Ser Glu Thr Thr Thr Cys Asn Cys Glu Ser Pro Gly Arg
             250                 255                 260

 aaa cct gca gtc cca aca gag aaa atg cca caa gaa gaa ttg cac atg      989
 Lys Pro Ala Val Pro Thr Glu Lys Met Pro Gln Glu Glu Leu His Met
         265                 270                 275

 aag gaa tgt cca cat ctt aag cct act cct agt caa tgc tgt ggt cat     1037
 Lys Glu Cys Pro His Leu Lys Pro Thr Pro Ser Gln Cys Cys Gly His
     280                 285                 290

 aga ctt gct gca gat cgt gtt cat gac agc cat cct aca aac atg acc     1085
 Arg Leu Ala Ala Asp Arg Val His Asp Ser His Pro Thr Asn Met Thr
 295                 300                 305                 310

 cct caa cat cct aag aca cat cca gaa tca tgc agt tat tgt cgg ctt     1133
 Pro Gln His Pro Lys Thr His Pro Glu Ser Cys Ser Tyr Cys Arg Leu
                 315                 320                 325

 tct tgg gca tct ctg gtg cat ggt gga ggg gca ctg caa ccc att gaa     1181
 Ser Trp Ala Ser Leu Val His Gly Gly Gly Ala Leu Gln Pro Ile Glu
             330                 335                 340

 act ttg aaa aag cag atc tca gaa gat aga aag cag caa ctg atg ctt     1229
 Thr Leu Lys Lys Gln Ile Ser Glu Asp Arg Lys Gln Gln Leu Met Leu
         345                 350                 355

 cag aaa atg gaa ctg gaa att gaa aag gag cgc ctt cag cat ctg ctg     1277
 Gln Lys Met Glu Leu Glu Ile Glu Lys Glu Arg Leu Gln His Leu Leu
     360                 365                 370

 gcc cag cag gag aca aag ctt ctt cta aaa cag cag cag ctt cac cag     1325
 Ala Gln Gln Glu Thr Lys Leu Leu Leu Lys Gln Gln Gln Leu His Gln
 375                 380                 385                 390

 tct cga ctg gat tac aat tgt tta ttg aag tca aac tgt gat ggc tgg     1373
 Ser Arg Leu Asp Tyr Asn Cys Leu Leu Lys Ser Asn Cys Asp Gly Trp
                 395                 400                 405

 ctg ctt gga aca tca tca tct att aaa aag cac caa gac ccc cca aac     1421
 Leu Leu Gly Thr Ser Ser Ser Ile Lys Lys His Gln Asp Pro Pro Asn
             410                 415                 420

 agt gga gag aat agg aag gag agg aag aca gtt ggg ttt cat tcg cat     1469
 Ser Gly Glu Asn Arg Lys Glu Arg Lys Thr Val Gly Phe His Ser His
         425                 430                 435

 atg aaa gat gat gcc cag tgg tca tgt caa aag aaa gat aca tgt aga     1517
 Met Lys Asp Asp Ala Gln Trp Ser Cys Gln Lys Lys Asp Thr Cys Arg
     440                 445                 450

 ccc caa aga ggg aca gtg aca gga gtt aga aaa gat gcg tct aca tct     1565
 Pro Gln Arg Gly Thr Val Thr Gly Val Arg Lys Asp Ala Ser Thr Ser
 455                 460                 465                 470

 cct atg cca aca gga agc cta aag gat ttt gtc acc aca gcc tca cca     1613
 Pro Met Pro Thr Gly Ser Leu Lys Asp Phe Val Thr Thr Ala Ser Pro
                 475                 480                 485

 tca tta cag cac acc acc tcc cgg tat gag aca tct ttg ttg gat ttg     1661
 Ser Leu Gln His Thr Thr Ser Arg Tyr Glu Thr Ser Leu Leu Asp Leu
             490                 495                 500

 gtt cag tct ctg agc cca aac tct gcg ccc aaa cct cag cgc tat ccc     1709
 Val Gln Ser Leu Ser Pro Asn Ser Ala Pro Lys Pro Gln Arg Tyr Pro
         505                 510                 515

 tcc aga gaa gct ggg gcc tgg aat cat ggt act ttc cga ctc agt cct     1757
 Ser Arg Glu Ala Gly Ala Trp Asn His Gly Thr Phe Arg Leu Ser Pro
     520                 525                 530

 cta aaa tca acc cgg aag aag atg ggg atg cac aga acc cct gaa gag     1805
 Leu Lys Ser Thr Arg Lys Lys Met Gly Met His Arg Thr Pro Glu Glu
 535                 540                 545                 550

 ttg gag gag aat cag att ctg gaa gat ata ttt ttc att tga catattg     1854
 Leu Glu Glu Asn Gln Ile Leu Glu Asp Ile Phe Phe Ile 
                 555                 560

 caaaattttc ttaggaaatt tgtgggtttc ctcacatact gatctaggat tttaaattat   1914

 ttcattgcaa agtaaaaaaa aaaaa                                         1939




      <210> 149
      <211> 1696
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(1560)

      <400> 149
 cccggcgtgt cc    atg tgt cag gtg ggc gag gac tac ggg gag ccg gcg      48
                  Met Cys Gln Val Gly Glu Asp Tyr Gly Glu Pro Ala
                    1               5                  10

 cct gag gag ccg ccc ccg gcg ccg cgg ccc agc cgt gag cag aag tgt       96
 Pro Glu Glu Pro Pro Pro Ala Pro Arg Pro Ser Arg Glu Gln Lys Cys
          15                  20                  25

 gtg aag tgc aag gaa gcg cag ccc gtt gtg gtg ata cga gcc gga gat      144
 Val Lys Cys Lys Glu Ala Gln Pro Val Val Val Ile Arg Ala Gly Asp
      30                  35                  40

 gcc ttc tgc agg gac tgt ttc aag gcc ttc tac gtc cac aag ttc aga      192
 Ala Phe Cys Arg Asp Cys Phe Lys Ala Phe Tyr Val His Lys Phe Arg
  45                  50                  55                  60

 gcc atg ctg ggc aag aac cgg ctc atc ttt cca ggc gag aag gtg ctc      240
 Ala Met Leu Gly Lys Asn Arg Leu Ile Phe Pro Gly Glu Lys Val Leu
                  65                  70                  75

 ttg gcg tgg tct ggg ggg cct tcg tcc agc tcc atg gtc tgg cag gtt      288
 Leu Ala Trp Ser Gly Gly Pro Ser Ser Ser Ser Met Val Trp Gln Val
              80                  85                  90

 ctt gag ggc ctg agc caa gat tct gcc aaa aga ctg cgc ttt gtg gca      336
 Leu Glu Gly Leu Ser Gln Asp Ser Ala Lys Arg Leu Arg Phe Val Ala
          95                 100                 105

 gga gtc atc ttt gtt gac gag gga gca gcc tgt ggc cag agc cta gag      384
 Gly Val Ile Phe Val Asp Glu Gly Ala Ala Cys Gly Gln Ser Leu Glu
     110                 115                 120

 gag aga tca aag acc ctg gcc gaa gtg aag ccc att ctg caa gca act      432
 Glu Arg Ser Lys Thr Leu Ala Glu Val Lys Pro Ile Leu Gln Ala Thr
 125                 130                 135                 140

 ggg ttc cca tgg cat gtg gtg gcc tta gag gag gtg ttc agc ctg cca      480
 Gly Phe Pro Trp His Val Val Ala Leu Glu Glu Val Phe Ser Leu Pro
                 145                 150                 155

 ccg tcg gtg ctt tgg tgc tct gcc cag gag ctg gtg gga tcc gag ggg      528
 Pro Ser Val Leu Trp Cys Ser Ala Gln Glu Leu Val Gly Ser Glu Gly
             160                 165                 170

 gcc tac aag gcg gcc gtg gac agc ttc ctc cag cag cag cat gtg ctg      576
 Ala Tyr Lys Ala Ala Val Asp Ser Phe Leu Gln Gln Gln His Val Leu
         175                 180                 185

 ggg gcc ggg ggt ggt ccc tgg ccc gac tca agg gga gga aca gcc acc      624
 Gly Ala Gly Gly Gly Pro Trp Pro Asp Ser Arg Gly Gly Thr Ala Thr
     190                 195                 200

 cca gcc ccc gct gga ccc cca gaa cct ggc aag acc gcc tgc cct gcc      672
 Pro Ala Pro Ala Gly Pro Pro Glu Pro Gly Lys Thr Ala Cys Pro Ala
 205                 210                 215                 220

 cag act gag gct ctt tcc caa ctg ttc tgc tca gtg agg aca ctg act      720
 Gln Thr Glu Ala Leu Ser Gln Leu Phe Cys Ser Val Arg Thr Leu Thr
                 225                 230                 235

 gcc aag gag gag ctt ctg cag acc ctg cgg acc cac ctg atc ctc cac      768
 Ala Lys Glu Glu Leu Leu Gln Thr Leu Arg Thr His Leu Ile Leu His
             240                 245                 250

 gtg gcc cga gcc cac ggc tac tcc aag gtc atg act ggg gac agc tgc      816
 Val Ala Arg Ala His Gly Tyr Ser Lys Val Met Thr Gly Asp Ser Cys
         255                 260                 265

 aca cgc ttg gct atc aag ctc atg acc aac ctg gcg ctg ggt cga ggg      864
 Thr Arg Leu Ala Ile Lys Leu Met Thr Asn Leu Ala Leu Gly Arg Gly
     270                 275                 280

 gcc ttc ctg gcc tgg gat acg ggc ttc tcg gat gag cgg cac ggg gac      912
 Ala Phe Leu Ala Trp Asp Thr Gly Phe Ser Asp Glu Arg His Gly Asp
 285                 290                 295                 300

 gtg gtg gtg gtg cgg ccc atg cgg gac cac acc ctg aag gag gtc gct      960
 Val Val Val Val Arg Pro Met Arg Asp His Thr Leu Lys Glu Val Ala
                 305                 310                 315

 ttc tac aac cgc ctg ttc tcc gtt cct tct gtc ttc aca cca gcc gtc     1008
 Phe Tyr Asn Arg Leu Phe Ser Val Pro Ser Val Phe Thr Pro Ala Val
             320                 325                 330

 gac acc aag gcc cct gaa aag gcc agc atc cac cgg ctg atg gag gcc     1056
 Asp Thr Lys Ala Pro Glu Lys Ala Ser Ile His Arg Leu Met Glu Ala
         335                 340                 345

 ttc atc ctc agg ctg cag acc cag ttc ccc tcc act gtc agc act gtg     1104
 Phe Ile Leu Arg Leu Gln Thr Gln Phe Pro Ser Thr Val Ser Thr Val
     350                 355                 360

 tac agg aca agt gag aag ctg gtg aag ggc ccc cgg gat ggc cct gct     1152
 Tyr Arg Thr Ser Glu Lys Leu Val Lys Gly Pro Arg Asp Gly Pro Ala
 365                 370                 375                 380

 gct ggc gac tcc ggc ccc cgc tgc ctc ctc tgc atg tgt gcc ctg gac     1200
 Ala Gly Asp Ser Gly Pro Arg Cys Leu Leu Cys Met Cys Ala Leu Asp
                 385                 390                 395

 gtc gac gcc gct gac agt gcc acg gct ttt ggg gct cag acc tcc tcg     1248
 Val Asp Ala Ala Asp Ser Ala Thr Ala Phe Gly Ala Gln Thr Ser Ser
             400                 405                 410

 cgt ctc tcc cag atg cag tca ccc atc ccc ctg act gag acc cgg aca     1296
 Arg Leu Ser Gln Met Gln Ser Pro Ile Pro Leu Thr Glu Thr Arg Thr
         415                 420                 425

 ccc ccg ggg ccc tgc tgt tct cca ggg gtg ggc tgg gcc cag cgc tgt     1344
 Pro Pro Gly Pro Cys Cys Ser Pro Gly Val Gly Trp Ala Gln Arg Cys
     430                 435                 440

 ggc cag ggg gcc tgc agg agg gag gac ccc caa gcc tgc att gag gag     1392
 Gly Gln Gly Ala Cys Arg Arg Glu Asp Pro Gln Ala Cys Ile Glu Glu
 445                 450                 455                 460

 cag ctg tgc tac agc tgc cgc gtg aac atg aag gac ttg ccc tca ctg     1440
 Gln Leu Cys Tyr Ser Cys Arg Val Asn Met Lys Asp Leu Pro Ser Leu
                 465                 470                 475

 gac ccc ctg ccg ccg tac atc ctg gct gag gcc cag ctc cgc aca cag     1488
 Asp Pro Leu Pro Pro Tyr Ile Leu Ala Glu Ala Gln Leu Arg Thr Gln
             480                 485                 490

 agg gcc tgg ggc ttg cag gag atc cgg gac tgt ctg att gag gac agt     1536
 Arg Ala Trp Gly Leu Gln Glu Ile Arg Asp Cys Leu Ile Glu Asp Ser
         495                 500                 505

 gac gac gag gcg ggc cag agc tga gcgtgaggac gtgcttgccg ggacagcagg    1590
 Asp Asp Glu Ala Gly Gln Ser 
     510                 515

 cagtggccac ctggtacacc acactggagc cggaaggcaa ggacggggga ctggcctctg   1650

 attgtccatt tgtataaata aaacattttt taattaaaaa aaaaaa                  1696




      <210> 150
      <211> 1169
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(1079)

      <400> 150
 ccagtataga ggtgtgatag ccaatgtagc attatttgac ggagtggttt ccaaaggaga     60

 taaaattgta tctgcacata ctcaaaagac atacgaagtt aatgaagtag gagtcttgaa    120

 tcctaatgag cagccaactc ataaattga  atg tat cct cta gac caa tct gaa     173
                                  Met Tyr Pro Leu Asp Gln Ser Glu
                                    1               5

 tat aac aat ctg aag agt gct ata gaa aaa ctg act tta aat gat tcc      221
 Tyr Asn Asn Leu Lys Ser Ala Ile Glu Lys Leu Thr Leu Asn Asp Ser
      10                  15                  20

 agt gtg acc gtt cat cgg gat agt agc ctt gct ctg ggt gct ggc tgg      269
 Ser Val Thr Val His Arg Asp Ser Ser Leu Ala Leu Gly Ala Gly Trp
  25                  30                  35                  40

 agg cta gga ttt ctt gga ctt ttg cac atg gaa gtt ttc aac cag cga      317
 Arg Leu Gly Phe Leu Gly Leu Leu His Met Glu Val Phe Asn Gln Arg
                  45                  50                  55

 ctg gag caa gaa tat aat gct tct gtt att tta aca acc cct act gtt      365
 Leu Glu Gln Glu Tyr Asn Ala Ser Val Ile Leu Thr Thr Pro Thr Val
              60                  65                  70

 cca tat aaa gct gta ctg tca tca tca aaa ttg ata aag gaa cat aga      413
 Pro Tyr Lys Ala Val Leu Ser Ser Ser Lys Leu Ile Lys Glu His Arg
          75                  80                  85

 gaa aaa gaa att aca att atc aat cct gca caa ttc ccc gat aaa tca      461
 Glu Lys Glu Ile Thr Ile Ile Asn Pro Ala Gln Phe Pro Asp Lys Ser
      90                  95                 100

 aaa gta aca gaa tat ttg gag cca gtt gtt ttg ggc act att atc aca      509
 Lys Val Thr Glu Tyr Leu Glu Pro Val Val Leu Gly Thr Ile Ile Thr
 105                 110                 115                 120

 cca gat gaa tac act gga aaa ata atg atg ctt tgc gag gct cga aga      557
 Pro Asp Glu Tyr Thr Gly Lys Ile Met Met Leu Cys Glu Ala Arg Arg
                 125                 130                 135

 gca gtt cag aag aat atg ata ttt att gat caa aat aga gtt atg ctt      605
 Ala Val Gln Lys Asn Met Ile Phe Ile Asp Gln Asn Arg Val Met Leu
             140                 145                 150

 aaa tat ctc ttt cct ttg aat gaa att gtg gta gat ttt tat gac tct      653
 Lys Tyr Leu Phe Pro Leu Asn Glu Ile Val Val Asp Phe Tyr Asp Ser
         155                 160                 165

 ttg aaa tcc cta tct tct gga tat gct agt ttt gat tac gaa gat gca      701
 Leu Lys Ser Leu Ser Ser Gly Tyr Ala Ser Phe Asp Tyr Glu Asp Ala
     170                 175                 180

 ggc tac cag act gca gaa ctt gta aaa atg gat att cta ctg aat gga      749
 Gly Tyr Gln Thr Ala Glu Leu Val Lys Met Asp Ile Leu Leu Asn Gly
 185                 190                 195                 200

 aat act gta gag gag cta gta act gtt gta cac aaa gac aaa gct cat      797
 Asn Thr Val Glu Glu Leu Val Thr Val Val His Lys Asp Lys Ala His
                 205                 210                 215

 tca att ggc aaa gcc ata tgt gaa cgg ctg aag gat tct ctt cct agg      845
 Ser Ile Gly Lys Ala Ile Cys Glu Arg Leu Lys Asp Ser Leu Pro Arg
             220                 225                 230

 caa ctg ttt gag ata gca att caa gct gct att gga agt aaa atc att      893
 Gln Leu Phe Glu Ile Ala Ile Gln Ala Ala Ile Gly Ser Lys Ile Ile
         235                 240                 245

 gca aga gaa act gtg aaa gcc tat agg aaa aac gtt ttg gca aaa tgt      941
 Ala Arg Glu Thr Val Lys Ala Tyr Arg Lys Asn Val Leu Ala Lys Cys
     250                 255                 260

 tat ggt ggt gat att acc cga aaa atg aag ctt ttg aag aga caa gca      989
 Tyr Gly Gly Asp Ile Thr Arg Lys Met Lys Leu Leu Lys Arg Gln Ala
 265                 270                 275                 280

 gaa ggg aaa aaa aag ctg agg aaa att ggc aac gtt gaa gtt cca aaa     1037
 Glu Gly Lys Lys Lys Leu Arg Lys Ile Gly Asn Val Glu Val Pro Lys
                 285                 290                 295

 gat gct ttt ata aaa gtt ctg aaa aca caa tct tct aaa taa ttggtgg     1086
 Asp Ala Phe Ile Lys Val Leu Lys Thr Gln Ser Ser Lys 
             300                 305

 gaaaacaaag aattttcatt gcaatttgta atatgctgac aacagaaaga aaattataaa   1146

 atttgcttgt taaaaaaaaa aaa                                           1169




      <210> 151
      <211> 4549
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4041)

      <400> 151
  atg gag agt tgc ggt ctt gct gca tct tct gta act ccc tgt tca gtg      48
  Met Glu Ser Cys Gly Leu Ala Ala Ser Ser Val Thr Pro Cys Ser Val
    1               5                  10                  15

 act tta caa cac cct agc ttg aaa tct gcc aag aga cga ttc cag ccc       96
 Thr Leu Gln His Pro Ser Leu Lys Ser Ala Lys Arg Arg Phe Gln Pro
              20                  25                  30

 ctt ccg tcc gcc gcg ctc cgc cgc tgt cct ccg ccg gcc cgc gtg gga      144
 Leu Pro Ser Ala Ala Leu Arg Arg Cys Pro Pro Pro Ala Arg Val Gly
          35                  40                  45

 gga cga tgg gtc agc gcg gaa aaa gtg aat gag ggc ggc agc ggt ggc      192
 Gly Arg Trp Val Ser Ala Glu Lys Val Asn Glu Gly Gly Ser Gly Gly
      50                  55                  60

 ggc ggt agc cag cgc ctg act cgg cgg gcc cgg agc acc gcc cgc gtc      240
 Gly Gly Ser Gln Arg Leu Thr Arg Arg Ala Arg Ser Thr Ala Arg Val
  65                  70                  75                  80

 ccg gcc ccc ggc acc atg gac gcg ccg cgc gcc tcg gcg gcc aag ccc      288
 Pro Ala Pro Gly Thr Met Asp Ala Pro Arg Ala Ser Ala Ala Lys Pro
                  85                  90                  95

 ccg acc ggg agg aag atg aag gct cgt gct ccc cca cct cct gga aag      336
 Pro Thr Gly Arg Lys Met Lys Ala Arg Ala Pro Pro Pro Pro Gly Lys
             100                 105                 110

 gct gcc act ctg cat gtg cac agt gac cag aag ccc ccc cac gat ggg      384
 Ala Ala Thr Leu His Val His Ser Asp Gln Lys Pro Pro His Asp Gly
         115                 120                 125

 gcc ctc ggg tcg cag cag aac ttg gtt cgc atg aag gag gcg ctg agg      432
 Ala Leu Gly Ser Gln Gln Asn Leu Val Arg Met Lys Glu Ala Leu Arg
     130                 135                 140

 gcc agc acc atg gac gtc acc gtg gtc ctg cct agc ggg ctg gag aag      480
 Ala Ser Thr Met Asp Val Thr Val Val Leu Pro Ser Gly Leu Glu Lys
 145                 150                 155                 160

 agg agc gtg ctc aat ggg agc cat gcg atg atg gac cta ctg gtt gaa      528
 Arg Ser Val Leu Asn Gly Ser His Ala Met Met Asp Leu Leu Val Glu
                 165                 170                 175

 ctt tgc ctt cag aac cac ctg aat cca tcc cac cat gcc ctt gaa att      576
 Leu Cys Leu Gln Asn His Leu Asn Pro Ser His His Ala Leu Glu Ile
             180                 185                 190

 cgg tct tca gaa acc caa caa cct ttg agt ttt aag cca aat act ttg      624
 Arg Ser Ser Glu Thr Gln Gln Pro Leu Ser Phe Lys Pro Asn Thr Leu
         195                 200                 205

 att ggg acc ctg aat gtg cat act gtg ttt ctg aaa gaa aaa gtt cct      672
 Ile Gly Thr Leu Asn Val His Thr Val Phe Leu Lys Glu Lys Val Pro
     210                 215                 220

 gaa gag aag gtt aag cct ggt ccc cct aag gtg cct gag aaa tct gtg      720
 Glu Glu Lys Val Lys Pro Gly Pro Pro Lys Val Pro Glu Lys Ser Val
 225                 230                 235                 240

 cgt ttg gtc gtg aat tac ctg cgg aca caa aaa gct gtt gtg cgt gtg      768
 Arg Leu Val Val Asn Tyr Leu Arg Thr Gln Lys Ala Val Val Arg Val
                 245                 250                 255

 agc cct gag gtt cct ctc cag aat att ctc cca gtc att tgt gca aag      816
 Ser Pro Glu Val Pro Leu Gln Asn Ile Leu Pro Val Ile Cys Ala Lys
             260                 265                 270

 tgt gag gtc agc cca gag cac gtg gtt ctc ctc agg gac aac att gcc      864
 Cys Glu Val Ser Pro Glu His Val Val Leu Leu Arg Asp Asn Ile Ala
         275                 280                 285

 gga gag gag ctg gag ctg tcc aag tcc ctg aac gag ctc ggg ata aag      912
 Gly Glu Glu Leu Glu Leu Ser Lys Ser Leu Asn Glu Leu Gly Ile Lys
     290                 295                 300

 gag ctc tac gcg tgg gac aac aga aga gaa acc ttt agg aaa tca tca      960
 Glu Leu Tyr Ala Trp Asp Asn Arg Arg Glu Thr Phe Arg Lys Ser Ser
 305                 310                 315                 320

 ctt ggc aat gat gag aca gat aaa gag aag aaa aaa ttt ctg gga ttt     1008
 Leu Gly Asn Asp Glu Thr Asp Lys Glu Lys Lys Lys Phe Leu Gly Phe
                 325                 330                 335

 ttc aaa gtt aat aaa aga agc aat agt aag ggc tgt tta acg acc ccc     1056
 Phe Lys Val Asn Lys Arg Ser Asn Ser Lys Gly Cys Leu Thr Thr Pro
             340                 345                 350

 aac tcc cca tcc atg cac tca cgt tct ctt acg ctg ggt cca tcc ctc     1104
 Asn Ser Pro Ser Met His Ser Arg Ser Leu Thr Leu Gly Pro Ser Leu
         355                 360                 365

 tcg ctg ggc agc atc tca ggg gtg tcc gtg aag tcg gag atg aag aag     1152
 Ser Leu Gly Ser Ile Ser Gly Val Ser Val Lys Ser Glu Met Lys Lys
     370                 375                 380

 cgc cga gcc cct cct cct cca ggt tca ggg cca cct gtg caa gac aag     1200
 Arg Arg Ala Pro Pro Pro Pro Gly Ser Gly Pro Pro Val Gln Asp Lys
 385                 390                 395                 400

 gca tcg gaa aag gta tct ctt ggg tca cag att gat tta cag aag aag     1248
 Ala Ser Glu Lys Val Ser Leu Gly Ser Gln Ile Asp Leu Gln Lys Lys
                 405                 410                 415

 aag cgg cga gcg cca gct ccc cct cca cca cag cca cca cca ccg agt     1296
 Lys Arg Arg Ala Pro Ala Pro Pro Pro Pro Gln Pro Pro Pro Pro Ser
             420                 425                 430

 ccc ctg atc ccc aac cgc act gag gat aag gag gag aac agg aag agc     1344
 Pro Leu Ile Pro Asn Arg Thr Glu Asp Lys Glu Glu Asn Arg Lys Ser
         435                 440                 445

 acg atg gta agc ctg ccc ctg ggg tct ggc agc cac tgc agc ccg gat     1392
 Thr Met Val Ser Leu Pro Leu Gly Ser Gly Ser His Cys Ser Pro Asp
     450                 455                 460

 gga gcc ccg cag gtg ctg tca gag gcg gag gag acc gtg tca gtt ggc     1440
 Gly Ala Pro Gln Val Leu Ser Glu Ala Glu Glu Thr Val Ser Val Gly
 465                 470                 475                 480

 agc tgt ttt gcg tcg gag gac acg acc gag gac tca gga gtg atg agt     1488
 Ser Cys Phe Ala Ser Glu Asp Thr Thr Glu Asp Ser Gly Val Met Ser
                 485                 490                 495

 tcc ccc tca gac atc gtc tct ctg gac tcg cag cag gac agc atg aaa     1536
 Ser Pro Ser Asp Ile Val Ser Leu Asp Ser Gln Gln Asp Ser Met Lys
             500                 505                 510

 tac aaa gac aag tgg gcc aca gac cag gaa gac tgc agt gac cag gac     1584
 Tyr Lys Asp Lys Trp Ala Thr Asp Gln Glu Asp Cys Ser Asp Gln Asp
         515                 520                 525

 ctc gct gga acc cca gac ctg ggt ccc cag aag agc ccc ttg tgg gag     1632
 Leu Ala Gly Thr Pro Asp Leu Gly Pro Gln Lys Ser Pro Leu Trp Glu
     530                 535                 540

 aag aat ggc tct gag aac tca cat ctg aga act gaa aaa gct gtc aca     1680
 Lys Asn Gly Ser Glu Asn Ser His Leu Arg Thr Glu Lys Ala Val Thr
 545                 550                 555                 560

 gcc tca aat gat gaa gaa gac cta tta att gct gga gag ttc cgt aaa     1728
 Ala Ser Asn Asp Glu Glu Asp Leu Leu Ile Ala Gly Glu Phe Arg Lys
                 565                 570                 575

 acc ctt gca gaa ctt gat gaa gac ctg gaa gaa atg gaa gac agc tat     1776
 Thr Leu Ala Glu Leu Asp Glu Asp Leu Glu Glu Met Glu Asp Ser Tyr
             580                 585                 590

 gaa aca gac acc agc tcc ctc acc agc tcc atc cat ggt gca tcc aac     1824
 Glu Thr Asp Thr Ser Ser Leu Thr Ser Ser Ile His Gly Ala Ser Asn
         595                 600                 605

 cac tgc cca cag gat gcc atg atc cct cac ggc gac aca gat gca atc     1872
 His Cys Pro Gln Asp Ala Met Ile Pro His Gly Asp Thr Asp Ala Ile
     610                 615                 620

 cca gta aca ttc ata ggg gaa gtt tca gat gat cct gtg gat tcg ggg     1920
 Pro Val Thr Phe Ile Gly Glu Val Ser Asp Asp Pro Val Asp Ser Gly
 625                 630                 635                 640

 ttg ttt tcc aat aga aac aac aat gct ggg tct ttc gac tcg gag ggt     1968
 Leu Phe Ser Asn Arg Asn Asn Asn Ala Gly Ser Phe Asp Ser Glu Gly
                 645                 650                 655

 gtt gcc agc agg aga gcc tcc ctg gcg cca ctt caa gct gag cac agc     2016
 Val Ala Ser Arg Arg Ala Ser Leu Ala Pro Leu Gln Ala Glu His Ser
             660                 665                 670

 cag ccc cat gaa aag gca agg gag gaa gta cct gcc ctg cac ccc gct     2064
 Gln Pro His Glu Lys Ala Arg Glu Glu Val Pro Ala Leu His Pro Ala
         675                 680                 685

 tcc cat gac atc gga aaa gga atc cgt gtg gcc tta tct aac atc tct     2112
 Ser His Asp Ile Gly Lys Gly Ile Arg Val Ala Leu Ser Asn Ile Ser
     690                 695                 700

 aaa gat ggg aat cta atg gaa acg gcg ccc agg gtg act tct ttt gct     2160
 Lys Asp Gly Asn Leu Met Glu Thr Ala Pro Arg Val Thr Ser Phe Ala
 705                 710                 715                 720

 tcg aat ctt cac aca gac aac cta aat gca aaa gtg aaa gac aaa gtg     2208
 Ser Asn Leu His Thr Asp Asn Leu Asn Ala Lys Val Lys Asp Lys Val
                 725                 730                 735

 tat ggc tgt gct gac ggg gag agg act caa gcc aca gag aga gtg aat     2256
 Tyr Gly Cys Ala Asp Gly Glu Arg Thr Gln Ala Thr Glu Arg Val Asn
             740                 745                 750

 tcc caa ccg gtg aat gaa aag gac agc aac gat aaa aac gct gcc ttg     2304
 Ser Gln Pro Val Asn Glu Lys Asp Ser Asn Asp Lys Asn Ala Ala Leu
         755                 760                 765

 gca cca aca tca tgg cac caa cga ggc caa aac cca ggg aaa agc tac     2352
 Ala Pro Thr Ser Trp His Gln Arg Gly Gln Asn Pro Gly Lys Ser Tyr
     770                 775                 780

 aga ctt aag cac ggc ctc aca acg tat aaa atc att cct cca aag tca     2400
 Arg Leu Lys His Gly Leu Thr Thr Tyr Lys Ile Ile Pro Pro Lys Ser
 785                 790                 795                 800

 gag atg cga tgt tac gac aga gat gtg tcc ctc tcc acc gga gcc att     2448
 Glu Met Arg Cys Tyr Asp Arg Asp Val Ser Leu Ser Thr Gly Ala Ile
                 805                 810                 815

 aag att gac gag ctg ggg aac ttg gtg agt cct cac gcc acc ggc atc     2496
 Lys Ile Asp Glu Leu Gly Asn Leu Val Ser Pro His Ala Thr Gly Ile
             820                 825                 830

 agg atc att tcc ctg tct tcg tct gtg cct gaa gca gaa tct cag ccc     2544
 Arg Ile Ile Ser Leu Ser Ser Ser Val Pro Glu Ala Glu Ser Gln Pro
         835                 840                 845

 att ggg aaa gtc aga gag ttc tgg agg tgc aac tct gtg gaa aaa cac     2592
 Ile Gly Lys Val Arg Glu Phe Trp Arg Cys Asn Ser Val Glu Lys His
     850                 855                 860

 ctg ggc cga ccc tca gag agc tct gcc agg gga ccc ccc tcc acc cct     2640
 Leu Gly Arg Pro Ser Glu Ser Ser Ala Arg Gly Pro Pro Ser Thr Pro
 865                 870                 875                 880

 gtg ccc acg cag acg cag aat cca gag agc aga ctc caa gca gac ccc     2688
 Val Pro Thr Gln Thr Gln Asn Pro Glu Ser Arg Leu Gln Ala Asp Pro
                 885                 890                 895

 aag cca ata tcg ccc cag cag aag tct gcc cac cat gag ggc cgg aac     2736
 Lys Pro Ile Ser Pro Gln Gln Lys Ser Ala His His Glu Gly Arg Asn
             900                 905                 910

 ccc cta ggg gag ggg aga aac cag ccc ccc acc atg ggc atg ggt cac     2784
 Pro Leu Gly Glu Gly Arg Asn Gln Pro Pro Thr Met Gly Met Gly His
         915                 920                 925

 gtg agg gtg cca gca gct cac acc aca gaa gtc aca ttt ctc aag cct     2832
 Val Arg Val Pro Ala Ala His Thr Thr Glu Val Thr Phe Leu Lys Pro
     930                 935                 940

 cag aga aga acg tcc agc cag tat gtg gcc tct gcc att gcc aag cgc     2880
 Gln Arg Arg Thr Ser Ser Gln Tyr Val Ala Ser Ala Ile Ala Lys Arg
 945                 950                 955                 960

 ata gga gcc cca aaa gtc cat gct gat gtg gtg agg cca cac ggt tat     2928
 Ile Gly Ala Pro Lys Val His Ala Asp Val Val Arg Pro His Gly Tyr
                 965                 970                 975

 gcc gag aag ggt tat gca ggc aag gcg cca gtg ctg gct gca cca cct     2976
 Ala Glu Lys Gly Tyr Ala Gly Lys Ala Pro Val Leu Ala Ala Pro Pro
             980                 985                 990

 gtc act gtg aaa gat gac agg aca tcc agc cca cac tca gag aca caa     3024
 Val Thr Val Lys Asp Asp Arg Thr Ser Ser Pro His Ser Glu Thr Gln
         995                1000                1005

 gga tgg aag gat ggt gcc cag tgg ccc tgt gtc act cct ccc aac aac     3072
 Gly Trp Lys Asp Gly Ala Gln Trp Pro Cys Val Thr Pro Pro Asn Asn
    1010                1015                1020

 cac ggg gaa gat ttg gca ggg gga gcc cct cct agg ggg gag gtc att     3120
 His Gly Glu Asp Leu Ala Gly Gly Ala Pro Pro Arg Gly Glu Val Ile
1025                1030                1035                1040

 ggc cca cac agg aag ttg tct act cag gac aga cct gct gct atc cac     3168
 Gly Pro His Arg Lys Leu Ser Thr Gln Asp Arg Pro Ala Ala Ile His
                1045                1050                1055

 aga agc tcc tgt ttc tca ctg gtt cag tct tcc cag agg gat cgt gtt     3216
 Arg Ser Ser Cys Phe Ser Leu Val Gln Ser Ser Gln Arg Asp Arg Val
            1060                1065                1070

 tct gtg gga cag agc tgt ggt ttc agt gga aag caa agc aca agt agc     3264
 Ser Val Gly Gln Ser Cys Gly Phe Ser Gly Lys Gln Ser Thr Ser Ser
        1075                1080                1085

 cag gag gcc agc tca gca tct gag ccc aga cgc gca cct gat ggt aca     3312
 Gln Glu Ala Ser Ser Ala Ser Glu Pro Arg Arg Ala Pro Asp Gly Thr
    1090                1095                1100

 gac cca ccc cct cca cac aca tct gac act cag gcc tgc agc agg gag     3360
 Asp Pro Pro Pro Pro His Thr Ser Asp Thr Gln Ala Cys Ser Arg Glu
1105                1110                1115                1120

 ctg gtc aat ggc tct gtg cgc gcc cca ggc cac ggc gag cct tcc cac     3408
 Leu Val Asn Gly Ser Val Arg Ala Pro Gly His Gly Glu Pro Ser His
                1125                1130                1135

 cct cca gga ggg tct ggc aca gaa agc cac att ctc cta gaa aga gag     3456
 Pro Pro Gly Gly Ser Gly Thr Glu Ser His Ile Leu Leu Glu Arg Glu
            1140                1145                1150

 gaa aag ccc agt gtg ttc tct aca gat gga aat gaa aca gac agt att     3504
 Glu Lys Pro Ser Val Phe Ser Thr Asp Gly Asn Glu Thr Asp Ser Ile
        1155                1160                1165

 tgg cca ccc agc att ttt ggg ccg aag aaa aaa ttc aaa cct gtt gtc     3552
 Trp Pro Pro Ser Ile Phe Gly Pro Lys Lys Lys Phe Lys Pro Val Val
    1170                1175                1180

 cag aga cca gtc cca aaa gac aca tcc ctg cac tct gcc ctg atg gaa     3600
 Gln Arg Pro Val Pro Lys Asp Thr Ser Leu His Ser Ala Leu Met Glu
1185                1190                1195                1200

 gcc atc cac tct gcg gga ggg aag gac aga cta cgc aag acg gca gaa     3648
 Ala Ile His Ser Ala Gly Gly Lys Asp Arg Leu Arg Lys Thr Ala Glu
                1205                1210                1215

 cac acc ggg gag ggc agg cca gcg aaa ctg tcc tac acg gag gca gag     3696
 His Thr Gly Glu Gly Arg Pro Ala Lys Leu Ser Tyr Thr Glu Ala Glu
            1220                1225                1230

 ggc gaa cga tct gca ctg ctg gca gct atc cgc ggg gca cag cgc acc     3744
 Gly Glu Arg Ser Ala Leu Leu Ala Ala Ile Arg Gly Ala Gln Arg Thr
        1235                1240                1245

 tgc agc ctg agg aag gtg gca tcc tct gct tct gag gag ctc cag agc     3792
 Cys Ser Leu Arg Lys Val Ala Ser Ser Ala Ser Glu Glu Leu Gln Ser
    1250                1255                1260

 ttc cga gat gcc gca ctc tct gca cag ggc tcg gaa agt cct ctg cta     3840
 Phe Arg Asp Ala Ala Leu Ser Ala Gln Gly Ser Glu Ser Pro Leu Leu
1265                1270                1275                1280

 gaa gac ctt ggt ctt ctg tcc cca cca gcc att ccc cca cca ccc cct     3888
 Glu Asp Leu Gly Leu Leu Ser Pro Pro Ala Ile Pro Pro Pro Pro Pro
                1285                1290                1295

 cca ccc tcc cag gct ctc tct gca cca agg acg gcc tcc agg ttc agc     3936
 Pro Pro Ser Gln Ala Leu Ser Ala Pro Arg Thr Ala Ser Arg Phe Ser
            1300                1305                1310

 acg ggc acc ctc agc aac acc gca gac gca agg caa gcc ttg atg gac     3984
 Thr Gly Thr Leu Ser Asn Thr Ala Asp Ala Arg Gln Ala Leu Met Asp
        1315                1320                1325

 gcc atc cgc tcc ggc aca ggg gct gcg aga ctg aga aag gtg ccc ttg     4032
 Ala Ile Arg Ser Gly Thr Gly Ala Ala Arg Leu Arg Lys Val Pro Leu
    1330                1335                1340

 ctc gtg tga atgaaca gaggccagag aattgcagaa acccacctgt aatatgccca     4088
 Leu Val 
1345

 caggcgtcac tcaaggagtc tgcatagcca ggaacatcaa gttttggtgt tactttcttg   4148

 tctacaggcc aaaatgcgca cagttgattt tcggtgtgtt cctgtataac ggcttgaaag   4208

 gaaaggagaa gatgctgtgt cgctgcgcag ctcgtgtgcc aaggaaatgt gttttgcctc   4268

 tgaatatctt aagttgctaa taaacgattc ttgttggcag gttaatggga ctataaatgc   4328

 tggagcccag cactcacact taattatatt tatgggcaaa gtaaaaagaa tcatgcctta   4388

 gactgatttt ggacctttga gacttttacc acatacagat ggatgaaact acttactgat   4448

 ttaagatctt ttgaatttta gaaaaaacat atgaatcaga tggaacaatc tgaatgtgat   4508

 atgctccatg atgctgtgtg ttttggtagt aaaaaaaaaa a                       4549




      <210> 152
      <211> 3352
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(1624)

      <400> 152
 gaagccagga aacctcgacg cgaaagtaga atat    atg aaa ctg ctg ccc aaa      52
                                          Met Lys Leu Leu Pro Lys
                                            1               5

 atc ctg gct cac tct att gaa cac aac cag cac att gag gag agc agg      100
 Ile Leu Ala His Ser Ile Glu His Asn Gln His Ile Glu Glu Ser Arg
              10                  15                  20

 cag ctg ctg tcc tat gct ttg ata cat cca gcc act tcg tta gaa gac      148
 Gln Leu Leu Ser Tyr Ala Leu Ile His Pro Ala Thr Ser Leu Glu Asp
          25                  30                  35

 cgt agt gct tta gcc atg tgg ctg aat cac ttg gag gac cgc acg tcg      196
 Arg Ser Ala Leu Ala Met Trp Leu Asn His Leu Glu Asp Arg Thr Ser
      40                  45                  50

 acc agc ttt ggt ggc cag aac cga ggc cgc tca gac tct gtg gat tat      244
 Thr Ser Phe Gly Gly Gln Asn Arg Gly Arg Ser Asp Ser Val Asp Tyr
  55                  60                  65                  70

 gga cag aca cac tac tat cac caa aga cag aac tct gat gac aag ctc      292
 Gly Gln Thr His Tyr Tyr His Gln Arg Gln Asn Ser Asp Asp Lys Leu
                  75                  80                  85

 aat ggg tgg cag aac tct cgg gat tct ggg att tgc atc aat gcc tcc      340
 Asn Gly Trp Gln Asn Ser Arg Asp Ser Gly Ile Cys Ile Asn Ala Ser
              90                  95                 100

 aac tgg cag gac aaa agc atg ggg tgt gag aat ggc cat gtg ccc ctc      388
 Asn Trp Gln Asp Lys Ser Met Gly Cys Glu Asn Gly His Val Pro Leu
         105                 110                 115

 tac tcc tcc tca tct gtc ccc acc aca atc aat acg att gga acc agc      436
 Tyr Ser Ser Ser Ser Val Pro Thr Thr Ile Asn Thr Ile Gly Thr Ser
     120                 125                 130

 aca agt aca aat gtt cca gcc tgg ctg aaa agc ctc cgc ctg cac aaa      484
 Thr Ser Thr Asn Val Pro Ala Trp Leu Lys Ser Leu Arg Leu His Lys
 135                 140                 145                 150

 tat gcc gcg ctt ttc tcc cag atg acc tat gag gag atg atg gcc ctc      532
 Tyr Ala Ala Leu Phe Ser Gln Met Thr Tyr Glu Glu Met Met Ala Leu
                 155                 160                 165

 acc gag tgc cag ctg gag gcg cag aat gtt acc aaa ggt gca aga cac      580
 Thr Glu Cys Gln Leu Glu Ala Gln Asn Val Thr Lys Gly Ala Arg His
             170                 175                 180

 aaa att gtc atc agt att cag aag ctc aaa gaa aga caa aat ctc ctg      628
 Lys Ile Val Ile Ser Ile Gln Lys Leu Lys Glu Arg Gln Asn Leu Leu
         185                 190                 195

 aag tct ttg gaa agg gac atc atc gag ggg ggc agc ctg cgc atc ccg      676
 Lys Ser Leu Glu Arg Asp Ile Ile Glu Gly Gly Ser Leu Arg Ile Pro
     200                 205                 210

 ctc cag gaa ctg cac cag atg atc ctg act ccg atc aag gcc tac agc      724
 Leu Gln Glu Leu His Gln Met Ile Leu Thr Pro Ile Lys Ala Tyr Ser
 215                 220                 225                 230

 tcc ccg agc acc acc ccc gag gct cgc cgc cgg gag ccc cag gcc ccg      772
 Ser Pro Ser Thr Thr Pro Glu Ala Arg Arg Arg Glu Pro Gln Ala Pro
                 235                 240                 245

 cgt cag ccc tca ctg atg ggc ccc gag agc cag agc ccc gac tgc aaa      820
 Arg Gln Pro Ser Leu Met Gly Pro Glu Ser Gln Ser Pro Asp Cys Lys
             250                 255                 260

 gat ggg gcc gca gcc act ggc gcc acg gcc acc ccc tcg gcc ggg gcc      868
 Asp Gly Ala Ala Ala Thr Gly Ala Thr Ala Thr Pro Ser Ala Gly Ala
         265                 270                 275

 agc ggg ggg ctc cag ccg cac cag ctg agc agc tgc gat ggg gag ctg      916
 Ser Gly Gly Leu Gln Pro His Gln Leu Ser Ser Cys Asp Gly Glu Leu
     280                 285                 290

 gcc gtc gcc ccc ctg cca gag ggg gac ctc ccc ggg cag ttc aca cgc      964
 Ala Val Ala Pro Leu Pro Glu Gly Asp Leu Pro Gly Gln Phe Thr Arg
 295                 300                 305                 310

 gtc atg ggg aaa gtg tgc aca cag ctc ttg gtc tcc aga cct gat gag     1012
 Val Met Gly Lys Val Cys Thr Gln Leu Leu Val Ser Arg Pro Asp Glu
                 315                 320                 325

 gaa aat ata agt tcc tat tta cag ctc ata gac aag tgt cta att cat     1060
 Glu Asn Ile Ser Ser Tyr Leu Gln Leu Ile Asp Lys Cys Leu Ile His
             330                 335                 340

 gag gca ttt aca gag aca cag aaa aaa aga ttg ttg tca tgg aaa cag     1108
 Glu Ala Phe Thr Glu Thr Gln Lys Lys Arg Leu Leu Ser Trp Lys Gln
         345                 350                 355

 cag gtg cag aag ctc ttt cgg tct ttc cct cgg aaa acc ctt cta gac     1156
 Gln Val Gln Lys Leu Phe Arg Ser Phe Pro Arg Lys Thr Leu Leu Asp
     360                 365                 370

 ata tca gga tat cga cag caa aga aat cga ggc ttt ggg caa tcc aac     1204
 Ile Ser Gly Tyr Arg Gln Gln Arg Asn Arg Gly Phe Gly Gln Ser Asn
 375                 380                 385                 390

 tcc ctc ccg acg gct ggc tct gtg ggc ggt ggc atg ggc aga cgg aac     1252
 Ser Leu Pro Thr Ala Gly Ser Val Gly Gly Gly Met Gly Arg Arg Asn
                 395                 400                 405

 ccg cgc cag tac cag atc ccc tct cgg aac gtc cct tcc gcc cgc ctg     1300
 Pro Arg Gln Tyr Gln Ile Pro Ser Arg Asn Val Pro Ser Ala Arg Leu
             410                 415                 420

 ggc ctc ttg ggc acc agt gga ttc gtc agc tcc aac cag cgc aac acc     1348
 Gly Leu Leu Gly Thr Ser Gly Phe Val Ser Ser Asn Gln Arg Asn Thr
         425                 430                 435

 aca gct acc ccc acc atc atg aaa caa gga aga cag aac ctg tgg ttt     1396
 Thr Ala Thr Pro Thr Ile Met Lys Gln Gly Arg Gln Asn Leu Trp Phe
     440                 445                 450

 gcc aac ccc ggg ggc agc aat agc atg cca agc cgc acc cac agc tca     1444
 Ala Asn Pro Gly Gly Ser Asn Ser Met Pro Ser Arg Thr His Ser Ser
 455                 460                 465                 470

 gtc cag agg acc cgc tcg ctg ccc gtg cac act tcc cca cag aac atg     1492
 Val Gln Arg Thr Arg Ser Leu Pro Val His Thr Ser Pro Gln Asn Met
                 475                 480                 485

 ctg atg ttc cag cag cca gaa ttc cag ctt ccc gtg acc gaa cct gac     1540
 Leu Met Phe Gln Gln Pro Glu Phe Gln Leu Pro Val Thr Glu Pro Asp
             490                 495                 500

 atc aac aac agg ctg gag tcg ttg tgc ctc agt atg acc gaa cac gcc     1588
 Ile Asn Asn Arg Leu Glu Ser Leu Cys Leu Ser Met Thr Glu His Ala
         505                 510                 515

 ctg gga gac ggg gtt gac cgg acc tcc acc atc tag aagc tgaagatgag     1638
 Leu Gly Asp Gly Val Asp Arg Thr Ser Thr Ile 
     520                 525

 agtgaccgcg ctggccgtga aatcgactgc tgcgggtcca gtgtccgcca tcttcagggt   1698

 tgcacagaat cctccaagat actttgcagc cttttttccc cctggtccct ctcccgtttt   1758

 gattttgtga gagcgtaggt catcctcgta aacatatcag tagacctggg gttggttatt   1818

 ttgtcatttg tttctgtcat gggatggttt ggtgtgtggg gtggggaggg gtctctaggg   1878

 aattatgaga ctgggagggg ggtggaggga atgcaggtag ctctctggat ggaacgggga   1938

 caggggaaag agtactgcca tgaaagagat aggagacaca taagaggaca gcagaagccc   1998

 tggccctggg gaggcttctc ggaaggcctg gcttcacagg caggccacag aaggatatcg   2058

 cgggcacgtg cacccaaagc aagatagtgg cttccctttt atatccaatc taatcctgat   2118

 tggatgtccc tgaggcccct gctggaaaca gccataggag agggcccatg gcagtagggg   2178

 aaagaaggaa gaaattccct gcaacaaaac ttcagctaaa ctttgatttg tgtattgttt   2238

 acataataat tttaaagggt acataatgtg taaagagttt ggatagaacc tctcttcata   2298

 ctatggtttt cgtaaaggat ctgttgttgt tacggattca tattttccct ctatttttat   2358

 aagagcagca gagttgtctt ctcaaaacgg ctgccaagct ctgcttcttg ggaagatgga   2418

 tgcagtcatg taggcctgag ctgtccgtct ttcaccgtta ggtgggagga gcgtatgggt   2478

 ggacttgaag gacatggacg tggctggaat gagcacagca ttgggtgagc gcacaaggat   2538

 gaggacatca tgtgatcagt tatgggtttg ctcgcagggc acccagagat tctcaaagaa   2598

 tcctgcagcc tctttctgtg ctggatttgc ttgtcacgga gaggcctccc tccctttcca   2658

 ccccacccat ggggcattat cctgtcactc ccagccttgc tccacacaca cacaggtggg   2718

 tacaagttcc actggaggag aaaaggcaag gatggacttt ttccccttgt gagaggtttg   2778

 atacccagaa aatgagctca aaacctttac attagggttg cttgtaggaa ctggagcctg   2838

 gaggctgcat ctacttcacc tgtcactgct gagggagagg aggggagaaa ggcccagcaa   2898

 cagcgtacag aggggtcagt cagcaagtcc agagagcaca tgcagggaga tgtttggccc   2958

 acaccgcaca gccccgccat ctccagtggg cgatgaaaga tgtaggaaag gttgatttca   3018

 agatggaaat gacagcgcta tccgcacagt atgaattagg gatttgctgt gttagttgat   3078

 ttatccatcc acacagaggg gaggaaaaag acactcgtta cttggtggga gattgagaaa   3138

 ctgtggtacc taccacaaag taatagctct gtttatgaag ggcaagaaag gctacatttc   3198

 agaatttgac acagtggagg gtattagagg aaatcaaaga ggagttgtgt ggaaaatcag   3258

 gttgtgtaaa tgaaggtatg aatgctcagc cagaggcaag atcagggaga tggtacaagg   3318

 cctgtttgtt acatggatga gtcgggtgcc tggt                               3352




      <210> 153
      <211> 2350
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (552)..(1640)

      <400> 153
 cccccccccc accccccggt cgggcgccga cggttccgtt tccggagtgg agggcacgcc     60

 agggtgtctg aagctgagac cccgggctcg cagtcgcccc atgaatttcg agttccgcaa    120

 ctgacgctac tgggcggggc ttcatggcca gggcctcgct caggcctaag tttccccacc    180

 tgtgctcaat gcacaggtgc ggtgccgcct ccagggccgg ccgagaagag aggccgcacc    240

 cgcacgggga ctgcatctcc cagagcgccc cgcgagcggc cgagcggcgg gactccatgc    300

 cctagagtgc cccgcgggcg gccgggcggc gggactccat gtcctagagt gccccgcggg    360

 cggccgggcg gcgggactcc atgtcctaga gtgccccgcg ggcggccggg cggcgggact    420

 ccatgtccta gagtgccccg cgggcggccg ggcggcggcc gccgcaaccg acaggtccgg    480

 gactgggcgc tgcggcctcg tccgcgcgcc ggggcggggg cctagctcga cagcttcccg    540

 gcggctgcgc g atg gac agc ccc gag gtg acc ttc act ctc gcc tat ctg     590
              Met Asp Ser Pro Glu Val Thr Phe Thr Leu Ala Tyr Leu
                1               5                  10

 gtg ttc gcc gtg tgc ttc gtg ttc acg ccc aac gag ttc cac gcg gcg      638
 Val Phe Ala Val Cys Phe Val Phe Thr Pro Asn Glu Phe His Ala Ala
      15                  20                  25

 ggg ctc acg gtg cag aac ctg ctg tcg ggc tgg ctg ggc agc gag gac      686
 Gly Leu Thr Val Gln Asn Leu Leu Ser Gly Trp Leu Gly Ser Glu Asp
  30                  35                  40                  45

 gcc gcc ttc gtg ccc ttc cac ttg cgc cgc acg gcc gcc acg ctg ttg      734
 Ala Ala Phe Val Pro Phe His Leu Arg Arg Thr Ala Ala Thr Leu Leu
                  50                  55                  60

 tgc cac tcg ctg ctg ccg ctc ggc tac tat gtg ggc atg tgc ctt gcg      782
 Cys His Ser Leu Leu Pro Leu Gly Tyr Tyr Val Gly Met Cys Leu Ala
              65                  70                  75

 gct tca gaa aag cgg ctc cac gcc ctc agc cag gcc cct gag gcc tgg      830
 Ala Ser Glu Lys Arg Leu His Ala Leu Ser Gln Ala Pro Glu Ala Trp
          80                  85                  90

 cgg ctc ttc ctg ctg ctg gcc gtg acc ctc ccc tcc atc gcc tgc atc      878
 Arg Leu Phe Leu Leu Leu Ala Val Thr Leu Pro Ser Ile Ala Cys Ile
      95                 100                 105

 ctg atc tac tac tgg tcc cgt gac cgg tgg gcc tgc cac cca ctg gcg      926
 Leu Ile Tyr Tyr Trp Ser Arg Asp Arg Trp Ala Cys His Pro Leu Ala
 110                 115                 120                 125

 cgc acc ctg gcc ctc tac gcc ctc cca cag tct ggc tgg cag gct gtt      974
 Arg Thr Leu Ala Leu Tyr Ala Leu Pro Gln Ser Gly Trp Gln Ala Val
                 130                 135                 140

 gcc tcc tct gtc aac act gag ttc cgg cgg att gac aag ttt gcc acc     1022
 Ala Ser Ser Val Asn Thr Glu Phe Arg Arg Ile Asp Lys Phe Ala Thr
             145                 150                 155

 ggt gca cca ggt gcc cgt gtg att gtg aca gac acg tgg gtg atg aag     1070
 Gly Ala Pro Gly Ala Arg Val Ile Val Thr Asp Thr Trp Val Met Lys
         160                 165                 170

 gta acc acc tac cga gtg cac gtg gcc cag cag cag gac gtg cac ctg     1118
 Val Thr Thr Tyr Arg Val His Val Ala Gln Gln Gln Asp Val His Leu
     175                 180                 185

 act gtg acg gag tct cgg cag cat gag ctc tcg cca gac tcg aac ttg     1166
 Thr Val Thr Glu Ser Arg Gln His Glu Leu Ser Pro Asp Ser Asn Leu
 190                 195                 200                 205

 ccc gtg cag ctc ctc acc atc cgt gtg gcc agc acc aac cct gct gtg     1214
 Pro Val Gln Leu Leu Thr Ile Arg Val Ala Ser Thr Asn Pro Ala Val
                 210                 215                 220

 cag gcc ttt gac atc tgg ctg aac tcc act gag tac ggg gag ctc tgc     1262
 Gln Ala Phe Asp Ile Trp Leu Asn Ser Thr Glu Tyr Gly Glu Leu Cys
             225                 230                 235

 gag aag ctc cgg gca ccc atc cgc agg gca gcc cat gtg gtc atc cac     1310
 Glu Lys Leu Arg Ala Pro Ile Arg Arg Ala Ala His Val Val Ile His
         240                 245                 250

 cag agc ctg ggc gac ctg ttc ctg gag aca ttt gcc tcc ctg gta gag     1358
 Gln Ser Leu Gly Asp Leu Phe Leu Glu Thr Phe Ala Ser Leu Val Glu
     255                 260                 265

 gtc aac ccg gcc tac tca gtg ccc agc agc cag gag ctg gag gcc tgc     1406
 Val Asn Pro Ala Tyr Ser Val Pro Ser Ser Gln Glu Leu Glu Ala Cys
 270                 275                 280                 285

 ata ggc tgc atg cag aca cgt gcc agc gtg aag ctg gtg aag acc tgc     1454
 Ile Gly Cys Met Gln Thr Arg Ala Ser Val Lys Leu Val Lys Thr Cys
                 290                 295                 300

 cag gag gca gcc aca ggc gag tgc cag cag tgt tac tgc cgc ccc atg     1502
 Gln Glu Ala Ala Thr Gly Glu Cys Gln Gln Cys Tyr Cys Arg Pro Met
             305                 310                 315

 tgg tgc ctc acc tgc atg ggc aag tgg ttc gcc agc cgc cag gac ccc     1550
 Trp Cys Leu Thr Cys Met Gly Lys Trp Phe Ala Ser Arg Gln Asp Pro
         320                 325                 330

 ctg cgc cct gac acc tgg ctg gcc agc cgc gtg ccc tgc ccc acc tgc     1598
 Leu Arg Pro Asp Thr Trp Leu Ala Ser Arg Val Pro Cys Pro Thr Cys
     335                 340                 345

 cgc gca cgc ttc tgc atc ctg gat gtg tgc acc gtg cgc tga gtgggct     1647
 Arg Ala Arg Phe Cys Ile Leu Asp Val Cys Thr Val Arg 
 350                 355                 360

 ggggccttga ggtgactctg tgtctccccc caaagccaca gggcagggaa gggggtggct   1707

 gggcctcctg gctggcaaag ggctctactt aaagcacatg atgtagagca actcgcctct   1767

 gccctgggtc tgcagaaggc tgaggacttt tggttaaaag caatcctcat gaaaacaccc   1827

 caccctgctt ggcagccagg gtacaagtcc tgggcacctc ctctttgcct ccctcctgcc   1887

 cctttcctgc tggtgggggc agatcctgca cacacagaca cagcgtctgc ccccgagcca   1947

 ttccctggag accctgggtc taccccaggt ggtcgtcatc tgggccattt gccttacttc   2007

 tctggagcat acccaccctc agttacgtgc cagacctgga ccgcattctc ctgccctgtc   2067

 ctggagctgg cccctggctg cctggaggac cctgggtagg tcctgagggt gggatggaga   2127

 agagggcact gctgtggtgt gggagcagtc ctggggcttc ctggtggctg tgaccagttg   2187

 aggggctgtt cctgggtggg gtggcaatgg gaggacaggt cagagcgccc tcatttgtgg   2247

 ggctgcccct ccgggtttct catcctgtcc ttggtgcctt tttctgccca acaagtccag   2307

 ggaaggccga ggtctcagac tcctgggtag gggggggggg tgg                     2350




      <210> 154
      <211> 1521
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (681)..(1499)

      <400> 154
 ggaattcccg ggtcgacgat ttcgtggaga taccgaagga gatactcttt agtattggga     60

 tcccagaaac cagtcctata tctggccaga gggacactgg gttgtggcat ctctctagct    120

 gctacccaga aggaacaggg ccccctgggg cctataggcc ttgcccctga ccctgggaac    180

 acccagctca ggcctgcccc agtggccaca agtcagggag gccgcaaatt tttaactaga    240

 aacattgatc attaataggg ggttagaaag agttcaaact aagtctcact ctgggacata    300

 gaccaattgt gcttcaggcc tcctgcagag atgctgggtc cccaagtctg gtcttctgtg    360

 aggcaggggc taagcaggag cttgtccagg aatgtggggg tctgggcctc aggggagggg    420

 aagaaggtgg acattgcggg tatctacccc cctgtgacca cccccttcac tgccactgca    480

 gaggtggact atgggaaact ggaggagaat ctgcacaaac tgggcacctt ccccttccga    540

 ggcttcgtgg tccagggctc caatggcgag tttcctttcc tgaccagcag tgagcgcctc    600

 gaggtggtga gccgtgtgcg ccaggccatg cccaagaaca ggctcctgct agctggctcc    660

 ggatgcgagt gtgagccaga    atg ccc tgg gcc ctg ggg gtg ggt gga tgt     710
                          Met Pro Trp Ala Leu Gly Val Gly Gly Cys
                            1               5                  10

 gca ggc cac gcg tcc ggc ttc gtg gtc cag ggc tcc aat ggc gag ttt      758
 Ala Gly His Ala Ser Gly Phe Val Val Gln Gly Ser Asn Gly Glu Phe
                  15                  20                  25

 cct ttc ctg acc agc agt gag cgc ctc gag gtg gtg agc cgt gtg cgc      806
 Pro Phe Leu Thr Ser Ser Glu Arg Leu Glu Val Val Ser Arg Val Arg
              30                  35                  40

 cag gcc atg ccc atg aac agg ctc ctg cta gct ggc tcc gga tgc gag      854
 Gln Ala Met Pro Met Asn Arg Leu Leu Leu Ala Gly Ser Gly Cys Glu
          45                  50                  55

 tcc act caa gcc aca gtg gag atg acc gtc agc atg gcc cag gtc ggg      902
 Ser Thr Gln Ala Thr Val Glu Met Thr Val Ser Met Ala Gln Val Gly
      60                  65                  70

 gct gac gcg gcc atg gtg gtg acc cct tgc tac tat cgt ggc cgc atg      950
 Ala Asp Ala Ala Met Val Val Thr Pro Cys Tyr Tyr Arg Gly Arg Met
  75                  80                  85                  90

 agc agt gcg gcc ctc att cac cac tac acc aag gtt gct gat ctc tct      998
 Ser Ser Ala Ala Leu Ile His His Tyr Thr Lys Val Ala Asp Leu Ser
                  95                 100                 105

 cca atc cct gtg gtg ctg tac agt gtc cca gcc aac aca ggg ctg gac     1046
 Pro Ile Pro Val Val Leu Tyr Ser Val Pro Ala Asn Thr Gly Leu Asp
             110                 115                 120

 ctg cct gtg gat gca gtg gtc acg ctt tcc cag cac ccg aat att gtg     1094
 Leu Pro Val Asp Ala Val Val Thr Leu Ser Gln His Pro Asn Ile Val
         125                 130                 135

 ggc atg aag gac agc ggt ggt gat gtg acc agg att ggg ctg att gtt     1142
 Gly Met Lys Asp Ser Gly Gly Asp Val Thr Arg Ile Gly Leu Ile Val
     140                 145                 150

 cac aag acc agg aag cag gat ttt cag gtg ttg gct gga tcg gct ggc     1190
 His Lys Thr Arg Lys Gln Asp Phe Gln Val Leu Ala Gly Ser Ala Gly
 155                 160                 165                 170

 ttt ctg atg gcc agc tat gcc ttg gga gct gtg ggg ggc gtc tgc gcc     1238
 Phe Leu Met Ala Ser Tyr Ala Leu Gly Ala Val Gly Gly Val Cys Ala
                 175                 180                 185

 ctg gcc aat gtc ctg ggg gct cag gtg tgc cag ctg gag cga ctg tgc     1286
 Leu Ala Asn Val Leu Gly Ala Gln Val Cys Gln Leu Glu Arg Leu Cys
             190                 195                 200

 tgc acg ggg caa tgg gaa gat gcc cag aaa ctg cag cac cgc ctc att     1334
 Cys Thr Gly Gln Trp Glu Asp Ala Gln Lys Leu Gln His Arg Leu Ile
         205                 210                 215

 gag cca aac gct gcg gtg acc cgg cgc ttt ggg atc cca ggg ctg aag     1382
 Glu Pro Asn Ala Ala Val Thr Arg Arg Phe Gly Ile Pro Gly Leu Lys
     220                 225                 230

 aaa atc atg gac tgg ttt ggc tac tat gga ggc ccc tgc cgc gcc ccc     1430
 Lys Ile Met Asp Trp Phe Gly Tyr Tyr Gly Gly Pro Cys Arg Ala Pro
 235                 240                 245                 250

 ttg cag gag ctg agc ccc gct gag gag gag gca ctg cgc atg gat ttc     1478
 Leu Gln Glu Leu Ser Pro Ala Glu Glu Glu Ala Leu Arg Met Asp Phe
                 255                 260                 265

 acc agc aac ggc tgg ctc tga gggcaggcag aacaacgaca gc                1521
 Thr Ser Asn Gly Trp Leu 
             270





      <210> 155
      <211> 1840
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(1550)

      <400> 155
 tttcgtaggc ttctcaggct cccacagcac cctcagtcat tcccccagcc gtggagcgag     60

 tgcagccagt g atg gcc cct gac gtc cca gca acc cca gtg gcc cct aca     110
              Met Ala Pro Asp Val Pro Ala Thr Pro Val Ala Pro Thr
                1               5                  10

 gag tca cag aca gtg ctg gat gcc ctg cag cag agg ctg aac aag tac      158
 Glu Ser Gln Thr Val Leu Asp Ala Leu Gln Gln Arg Leu Asn Lys Tyr
      15                  20                  25

 cgc gag gcg ggc atc cag gcc cgg agt ggt ggg gac gag cgc aag gct      206
 Arg Glu Ala Gly Ile Gln Ala Arg Ser Gly Gly Asp Glu Arg Lys Ala
  30                  35                  40                  45

 cgg atg cat gag cgc att gcc aag caa tat caa gat gct att cga gca      254
 Arg Met His Glu Arg Ile Ala Lys Gln Tyr Gln Asp Ala Ile Arg Ala
                  50                  55                  60

 cac cga gca gga cgg aaa gtc aac ttt gct gaa ttg cct gtt cct cca      302
 His Arg Ala Gly Arg Lys Val Asn Phe Ala Glu Leu Pro Val Pro Pro
              65                  70                  75

 gga ttt ccc ccc atc cct ggc ctg gag tcc act atg ggt gtt gag gag      350
 Gly Phe Pro Pro Ile Pro Gly Leu Glu Ser Thr Met Gly Val Glu Glu
          80                  85                  90

 gac gca gtg gca gcg aca ttg gca gct gca gag aaa ctg gcc tct gca      398
 Asp Ala Val Ala Ala Thr Leu Ala Ala Ala Glu Lys Leu Ala Ser Ala
      95                 100                 105

 gag gat tca gcc ccg gct gat aaa gac gag gac gag cct cct ggg cac      446
 Glu Asp Ser Ala Pro Ala Asp Lys Asp Glu Asp Glu Pro Pro Gly His
 110                 115                 120                 125

 ctg cag ggt gag ccc cca gca cag gcc cca gtg gcc aag aaa cct gca      494
 Leu Gln Gly Glu Pro Pro Ala Gln Ala Pro Val Ala Lys Lys Pro Ala
                 130                 135                 140

 cgg ccc aca gtc cct tca tcc cag cgc ctg cct gag ccc agg gcc tca      542
 Arg Pro Thr Val Pro Ser Ser Gln Arg Leu Pro Glu Pro Arg Ala Ser
             145                 150                 155

 agt tct aag gag tca ccg agt cca tct gtg cgg gag cag ctg gca ctg      590
 Ser Ser Lys Glu Ser Pro Ser Pro Ser Val Arg Glu Gln Leu Ala Leu
         160                 165                 170

 ctg gag gca cgg aaa ctg cag tat cag cgg gca gcc ctg cag gcc aag      638
 Leu Glu Ala Arg Lys Leu Gln Tyr Gln Arg Ala Ala Leu Gln Ala Lys
     175                 180                 185

 cgc agc cag gac ctg gag cag gcc aaa gcc tat ctg cgg gta gcc aaa      686
 Arg Ser Gln Asp Leu Glu Gln Ala Lys Ala Tyr Leu Arg Val Ala Lys
 190                 195                 200                 205

 tgg ctt gag gct cag atc atc cag gcc cga tct ggc aga cct gtt gat      734
 Trp Leu Glu Ala Gln Ile Ile Gln Ala Arg Ser Gly Arg Pro Val Asp
                 210                 215                 220

 ctg tcc aag gtg cct tcg ccc ttg acg gat gag gag ggt gac ttc atc      782
 Leu Ser Lys Val Pro Ser Pro Leu Thr Asp Glu Glu Gly Asp Phe Ile
             225                 230                 235

 ctc atc cac cat gag gac ctg cga ctc tcc cag aag gcg gag gag gtg      830
 Leu Ile His His Glu Asp Leu Arg Leu Ser Gln Lys Ala Glu Glu Val
         240                 245                 250

 tat gcc cag ctg caa aaa atg ctt ctg gag caa caa gag aag tgc ctg      878
 Tyr Ala Gln Leu Gln Lys Met Leu Leu Glu Gln Gln Glu Lys Cys Leu
     255                 260                 265

 ctg ttc tcc aag cag ttc atg cac cag ggc aac gtg gct gag acc acc      926
 Leu Phe Ser Lys Gln Phe Met His Gln Gly Asn Val Ala Glu Thr Thr
 270                 275                 280                 285

 cga ttt gag aag ctt gct cag gac cgc aag aaa cag ctg gag atc ctg      974
 Arg Phe Glu Lys Leu Ala Gln Asp Arg Lys Lys Gln Leu Glu Ile Leu
                 290                 295                 300

 cag ctg gcc cag gct cag ggc ctc gac cct ccc acc cac cac ttt gag     1022
 Gln Leu Ala Gln Ala Gln Gly Leu Asp Pro Pro Thr His His Phe Glu
             305                 310                 315

 ttg aag aca ttc cag act gtg agg atc ttc tca gaa ctc aac agc aca     1070
 Leu Lys Thr Phe Gln Thr Val Arg Ile Phe Ser Glu Leu Asn Ser Thr
         320                 325                 330

 gaa atg cat ctg atc att gtc cgg gga atg aac ctc cca gcc cct cca     1118
 Glu Met His Leu Ile Ile Val Arg Gly Met Asn Leu Pro Ala Pro Pro
     335                 340                 345

 ggg gtg act ccc gat gac ctg gat gct ttt gtg cgg ttt gag ttt cac     1166
 Gly Val Thr Pro Asp Asp Leu Asp Ala Phe Val Arg Phe Glu Phe His
 350                 355                 360                 365

 tac cct aac tcg gac cag gct caa aaa agc aaa aca gct gtg gtg aag     1214
 Tyr Pro Asn Ser Asp Gln Ala Gln Lys Ser Lys Thr Ala Val Val Lys
                 370                 375                 380

 aac aca aac tct cca gaa ttt gat caa ctc ttc aaa cta aac atc aac     1262
 Asn Thr Asn Ser Pro Glu Phe Asp Gln Leu Phe Lys Leu Asn Ile Asn
             385                 390                 395

 cga aac cac cgg ggc ttc aag agg gtg atc cag agc aaa ggc atc aag     1310
 Arg Asn His Arg Gly Phe Lys Arg Val Ile Gln Ser Lys Gly Ile Lys
         400                 405                 410

 ttt gag atc ttc cac aaa ggg tcc ttc ttc aga agc gac aag ctg gtt     1358
 Phe Glu Ile Phe His Lys Gly Ser Phe Phe Arg Ser Asp Lys Leu Val
     415                 420                 425

 ggc aca gca cac ctg aaa ctg gag cgg ctg gag aat gag tgt gag atc     1406
 Gly Thr Ala His Leu Lys Leu Glu Arg Leu Glu Asn Glu Cys Glu Ile
 430                 435                 440                 445

 aga gaa att gtg gag gtc ctg gat gga agg aag ccc acc ggg ggg aag     1454
 Arg Glu Ile Val Glu Val Leu Asp Gly Arg Lys Pro Thr Gly Gly Lys
                 450                 455                 460

 ctg gag gtg aag gtg agg ctg cgg gag cct ctg agt ggc cag gat gtg     1502
 Leu Glu Val Lys Val Arg Leu Arg Glu Pro Leu Ser Gly Gln Asp Val
             465                 470                 475

 cag atg gtc act gag aac tgg ctg gtt ctg gag ccc agg ggc ttg tga     1550
 Gln Met Val Thr Glu Asn Trp Leu Val Leu Glu Pro Arg Gly Leu 
         480                 485                 490

 ggtgggcagc tctctgggcc ttcagaacct ttgccccctc cttttactca actaactact   1610

 caactcatat ctggagagaa aacctaggag tttctcatct atgagaaaga cctaccatgc   1670

 tgggtagggc ttatgggctg agtttctgat gttcctcagt agaactggga agagaaggta   1730

 accttccaag gtttaactat ctatctatct atctatcttc aggaaaccct ttctaaaatc   1790

 tttgtgtttt cactgcagtt tagactgact tcttgtgctt tgcacccctg              1840




      <210> 156
      <211> 1987
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (420)..(1703)

      <400> 156
 gcgagcctct ctggtcccga cgcgggtggc ccgggtctcc tcgactcctg aggaaagccc     60

 accgggcggg gcgggaggtg aagaggctgg ggaagtcaga ggttaacctg ggcgtcaggg    120

 gacgttggag ttgatccgtc agggtcccgg ggcggtctgg gggcagtaga gacggggctt    180

 gggcgcgggg cctgagaggt caggggtcag caggagtgag gctggggcgt ccaggtccga    240

 gaggtcaggg gtcagctgga gaggggctgg ggcgccggtt tcccggaggt caggggtcag    300

 aaggaacagg gctgcagcgt cagggtccga gaggttaggg gtcggcagag gcggagctgg    360

 ggcactgggg gtcaggggtc ggggatcagg gcggggtcgg gtgcactggt agcctgcgc     419                                                                 
 atg ggc ctc cag ctt cgc gcg ctg ttg gga gcc ttc gga cgg tgg acc      467
 Met Gly Leu Gln Leu Arg Ala Leu Leu Gly Ala Phe Gly Arg Trp Thr
   1               5                  10                  15

 ctg cgc ctg gga ccg cgt ccg tcc tgc tcg ccg cgc atg gcc ggg aac      515
 Leu Arg Leu Gly Pro Arg Pro Ser Cys Ser Pro Arg Met Ala Gly Asn
              20                  25                  30

 gcg gag ccg ccg ccc gcc gga gcc gca tgc ccc cag gac cgg agg tcc      563
 Ala Glu Pro Pro Pro Ala Gly Ala Ala Cys Pro Gln Asp Arg Arg Ser
          35                  40                  45

 tgc agc ggc cgg gcc ggg ggc gac cgc gtc tgg gag gac gga gaa cat      611
 Cys Ser Gly Arg Ala Gly Gly Asp Arg Val Trp Glu Asp Gly Glu His
      50                  55                  60

 ccg gcg aag aag ctc aag agc ggt ggc gac gag gag cgg cgc gag aag      659
 Pro Ala Lys Lys Leu Lys Ser Gly Gly Asp Glu Glu Arg Arg Glu Lys
  65                  70                  75                  80

 ccg ccc aag cgg aag atc gtg ctg ctc atg gcc tat tcg ggc aag ggc      707
 Pro Pro Lys Arg Lys Ile Val Leu Leu Met Ala Tyr Ser Gly Lys Gly
                  85                  90                  95

 tac cac ggc atg cag agg aat gtc ggg tcc tca caa ttc aaa aca att      755
 Tyr His Gly Met Gln Arg Asn Val Gly Ser Ser Gln Phe Lys Thr Ile
             100                 105                 110

 gaa gat gac ttg gtg tcc gcc ctc gtc cgg tca ggc tgt att cct gaa      803
 Glu Asp Asp Leu Val Ser Ala Leu Val Arg Ser Gly Cys Ile Pro Glu
         115                 120                 125

 aat cat ggt gag gac atg agg aaa atg tcc ttc cag cgc tgc gcc cgg      851
 Asn His Gly Glu Asp Met Arg Lys Met Ser Phe Gln Arg Cys Ala Arg
     130                 135                 140

 aca gac aag ggt gtg tcc gca gcc ggc cag gtg gta tcc ctg aag gtg      899
 Thr Asp Lys Gly Val Ser Ala Ala Gly Gln Val Val Ser Leu Lys Val
 145                 150                 155                 160

 tgg ctg att gac gac att cta gaa aag atc aac agc cac ctt ccc tct      947
 Trp Leu Ile Asp Asp Ile Leu Glu Lys Ile Asn Ser His Leu Pro Ser
                 165                 170                 175

 cac att cgg att ctg gga ctg aag cgg gtc acg ggc ggg ttt aac tcc      995
 His Ile Arg Ile Leu Gly Leu Lys Arg Val Thr Gly Gly Phe Asn Ser
             180                 185                 190

 aag aac aga tgt gat gcc agg acc tat tgc tac ctg ctg ccc acg ttt     1043
 Lys Asn Arg Cys Asp Ala Arg Thr Tyr Cys Tyr Leu Leu Pro Thr Phe
         195                 200                 205

 gcc ttt gcg cac aag gac cgg gac gtt cag gat gag acc tac cgc ctg     1091
 Ala Phe Ala His Lys Asp Arg Asp Val Gln Asp Glu Thr Tyr Arg Leu
     210                 215                 220

 agc gcc gag acg ctg cag cag gtc aac agg ctc ctg gcc tgc tac aag     1139
 Ser Ala Glu Thr Leu Gln Gln Val Asn Arg Leu Leu Ala Cys Tyr Lys
 225                 230                 235                 240

 ggc acg cac aac ttc cac aat ttc acc tcg cag aag ggg ccg cag gat     1187
 Gly Thr His Asn Phe His Asn Phe Thr Ser Gln Lys Gly Pro Gln Asp
                 245                 250                 255

 ccc agt gcc tgc cgc tac atc ctg gag atg tac tgc gag gaa ccc ttt     1235
 Pro Ser Ala Cys Arg Tyr Ile Leu Glu Met Tyr Cys Glu Glu Pro Phe
             260                 265                 270

 gtg cgg gag ggc ctg gag ttt gcg gtg atc agg gtg aag ggc cag agc     1283
 Val Arg Glu Gly Leu Glu Phe Ala Val Ile Arg Val Lys Gly Gln Ser
         275                 280                 285

 ttc atg atg cat cag atc cgg aag atg gtc ggc ctg gtg gtg gcc att     1331
 Phe Met Met His Gln Ile Arg Lys Met Val Gly Leu Val Val Ala Ile
     290                 295                 300

 gtg aag ggt tat gcc cct gag agc gtg ctg gag cgc agc tgg ggc aca     1379
 Val Lys Gly Tyr Ala Pro Glu Ser Val Leu Glu Arg Ser Trp Gly Thr
 305                 310                 315                 320

 gag aag gtg gac gtg ccc aag gcg ccc gga ctc ggc ctg gtc ctg gag     1427
 Glu Lys Val Asp Val Pro Lys Ala Pro Gly Leu Gly Leu Val Leu Glu
                 325                 330                 335

 agg gtg cac ttc gag aag tac aac cag cgc ttt ggc aac gat ggg ctg     1475
 Arg Val His Phe Glu Lys Tyr Asn Gln Arg Phe Gly Asn Asp Gly Leu
             340                 345                 350

 cat gag ccg ctg gac tgg gcg cag gag gaa gga aag gtc gca gcc ttc     1523
 His Glu Pro Leu Asp Trp Ala Gln Glu Glu Gly Lys Val Ala Ala Phe
         355                 360                 365

 aag gag gag cac atc tac ccc acc atc atc ggc acc gag cgg gac gaa     1571
 Lys Glu Glu His Ile Tyr Pro Thr Ile Ile Gly Thr Glu Arg Asp Glu
     370                 375                 380

 cgc tcc atg gcc cag tgg ctg agc acc ttg ccc atc cac aac ttc agt     1619
 Arg Ser Met Ala Gln Trp Leu Ser Thr Leu Pro Ile His Asn Phe Ser
 385                 390                 395                 400

 gcc acc gct ctc acg gca ggt ggc acg ggc gcc aag gtg ccc agt ccc     1667
 Ala Thr Ala Leu Thr Ala Gly Gly Thr Gly Ala Lys Val Pro Ser Pro
                 405                 410                 415

 ctg gaa ggc agt gaa ggg gac gga gac act gac tga ggcg atgggagctg     1717
 Leu Glu Gly Ser Glu Gly Asp Gly Asp Thr Asp 
             420                 425

 cccaccagag tgcctctgag cagctcacag tgtgtgccca gatgtgccac ccctgtgggc   1777

 agcaagaagc tgggatcgct gcagccatgt tttcccggcc atgccggcgt tgtaacctca   1837

 ggaccttccc ttgtaggaac agcctttctc gaatctgttt tcagctcttg cattgcatag   1897

 atgaacctca gcatgtaaag aactattttt ttaaagaagt gattttctta ttaaacaagt   1957

 acaaattttg cttagtcaaa aaaaaaaaaa                                    1987




      <210> 157
      <211> 2044
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(1962)

      <400> 157
 ggaaaaggga cttgcaaagg acacagagca agcggtttca gctgtactct gctaatgtaa     60

 caggga   atg act caa atg gta tct aaa aag cca agg aaa tgt gat ttg     108
          Met Thr Gln Met Val Ser Lys Lys Pro Arg Lys Cys Asp Leu
            1               5                  10

 act ccc ttc ctg gtt ttg aaa gca aga aag aaa caa aag ttc acc tct      156
 Thr Pro Phe Leu Val Leu Lys Ala Arg Lys Lys Gln Lys Phe Thr Ser
  15                  20                  25                  30

 gcg aag ggc ccc act ctt tct gag atc tac atg gtt gga agt aaa ctt      204
 Ala Lys Gly Pro Thr Leu Ser Glu Ile Tyr Met Val Gly Ser Lys Leu
                  35                  40                  45

 tcg gtt cag atc cag aag cca cct tcc aat atc aag aac tcc aga atg      252
 Ser Val Gln Ile Gln Lys Pro Pro Ser Asn Ile Lys Asn Ser Arg Met
              50                  55                  60

 acc caa gtc ttt cat aag aac acc agt gtt act tca ctc ccc ttt gtg      300
 Thr Gln Val Phe His Lys Asn Thr Ser Val Thr Ser Leu Pro Phe Val
          65                  70                  75

 gac acc aag ggg aag aag aat acg gta agc ttc cca cac att agc aag      348
 Asp Thr Lys Gly Lys Lys Asn Thr Val Ser Phe Pro His Ile Ser Lys
      80                  85                  90

 aaa gtc ctg ctg aag tca tcc ctg ctg tat cag gag aat caa gct cac      396
 Lys Val Leu Leu Lys Ser Ser Leu Leu Tyr Gln Glu Asn Gln Ala His
  95                 100                 105                 110

 aat cag atg ccg gcc tca gag ctc aag gct tca gaa ata cct ttc cac      444
 Asn Gln Met Pro Ala Ser Glu Leu Lys Ala Ser Glu Ile Pro Phe His
                 115                 120                 125

 cct agc att aaa acc cag gat ccc aag gca gag gag aag tca cca aag      492
 Pro Ser Ile Lys Thr Gln Asp Pro Lys Ala Glu Glu Lys Ser Pro Lys
             130                 135                 140

 aag caa aag gtg act ctg aca gcg gca gag gcc cta aag ctt ttt aag      540
 Lys Gln Lys Val Thr Leu Thr Ala Ala Glu Ala Leu Lys Leu Phe Lys
         145                 150                 155

 aac cag ctg tct cca tat gaa caa agt gaa atc ctg ggc tac gcg gag      588
 Asn Gln Leu Ser Pro Tyr Glu Gln Ser Glu Ile Leu Gly Tyr Ala Glu
     160                 165                 170

 ctg tgg ttc ctg ggt ctt gaa gcc aag aag ctc gac acg gct cct gag      636
 Leu Trp Phe Leu Gly Leu Glu Ala Lys Lys Leu Asp Thr Ala Pro Glu
 175                 180                 185                 190

 aaa ttt agc aag acg agt ttt gat gat gag cat ggc ttc tat ctg aag      684
 Lys Phe Ser Lys Thr Ser Phe Asp Asp Glu His Gly Phe Tyr Leu Lys
                 195                 200                 205

 gtc ctg cat gat cac att gcc tac cgc tat gaa gtt ctg gag aca atc      732
 Val Leu His Asp His Ile Ala Tyr Arg Tyr Glu Val Leu Glu Thr Ile
             210                 215                 220

 ggg aag ggg tcc ttt gga cag gtg gcc aag tgc ttg gat cac aaa aac      780
 Gly Lys Gly Ser Phe Gly Gln Val Ala Lys Cys Leu Asp His Lys Asn
         225                 230                 235

 aat gag ctg gtg gcc ctg aaa atc atc agg aac aag aag agg ttt cac      828
 Asn Glu Leu Val Ala Leu Lys Ile Ile Arg Asn Lys Lys Arg Phe His
     240                 245                 250

 cag cag gcc ctg atg gag ctg aag atc ctg gaa gct ctc aga aag aag      876
 Gln Gln Ala Leu Met Glu Leu Lys Ile Leu Glu Ala Leu Arg Lys Lys
 255                 260                 265                 270

 gac aaa gac aac acc tac aat gtg gtg cat atg aag gac ttt ttc tac      924
 Asp Lys Asp Asn Thr Tyr Asn Val Val His Met Lys Asp Phe Phe Tyr
                 275                 280                 285

 ttt cgc aat cac ttc tgc atc acc ttt gag ctc ctg gga atc aac ttg      972
 Phe Arg Asn His Phe Cys Ile Thr Phe Glu Leu Leu Gly Ile Asn Leu
             290                 295                 300

 tat gag ttg atg aag aat aac aac ttt caa ggc ttc agt ctg tcc ata     1020
 Tyr Glu Leu Met Lys Asn Asn Asn Phe Gln Gly Phe Ser Leu Ser Ile
         305                 310                 315

 gtt cgg cgc ttc act ctc tct gtt ttg aag tgc ttg cag atg ctt tcg     1068
 Val Arg Arg Phe Thr Leu Ser Val Leu Lys Cys Leu Gln Met Leu Ser
     320                 325                 330

 gta gag aaa atc att cac tgt gat ctc aag ccc gaa aat ata gtg cta     1116
 Val Glu Lys Ile Ile His Cys Asp Leu Lys Pro Glu Asn Ile Val Leu
 335                 340                 345                 350

 tac caa aag ggc caa gcc tct gtt aaa gtc att gac ttt gga tca agc     1164
 Tyr Gln Lys Gly Gln Ala Ser Val Lys Val Ile Asp Phe Gly Ser Ser
                 355                 360                 365

 tgt tat gaa cac cag aaa gta tac acg tac atc caa agc cgg ttc tac     1212
 Cys Tyr Glu His Gln Lys Val Tyr Thr Tyr Ile Gln Ser Arg Phe Tyr
             370                 375                 380

 cga tcc cca gaa gtg atc ctg ggc cac ccc tac gac gtg gcc att gac     1260
 Arg Ser Pro Glu Val Ile Leu Gly His Pro Tyr Asp Val Ala Ile Asp
         385                 390                 395

 atg tgg agc ctg ggc tgc atc acg gcg gag ttg tac acg ggc tac ccc     1308
 Met Trp Ser Leu Gly Cys Ile Thr Ala Glu Leu Tyr Thr Gly Tyr Pro
     400                 405                 410

 ctg ttc ccc ggg gag aat gag gtg gag cag ctg gcc tgc atc atg gag     1356
 Leu Phe Pro Gly Glu Asn Glu Val Glu Gln Leu Ala Cys Ile Met Glu
 415                 420                 425                 430

 gtg ctg ggt ctg ccg cca gcc ggc ttc att cag aca gcc tcc agg aga     1404
 Val Leu Gly Leu Pro Pro Ala Gly Phe Ile Gln Thr Ala Ser Arg Arg
                 435                 440                 445

 cag aca ttc ttt gat tcc aaa ggt ttt cct aaa aat ata acc aac aac     1452
 Gln Thr Phe Phe Asp Ser Lys Gly Phe Pro Lys Asn Ile Thr Asn Asn
             450                 455                 460

 agg ggg aaa aaa aga tac cca gat tcc aag gac ctc acg atg gtg ctg     1500
 Arg Gly Lys Lys Arg Tyr Pro Asp Ser Lys Asp Leu Thr Met Val Leu
         465                 470                 475

 aaa acc tat gac acc agc ttc ctg gac ttt ctc aga agg tgt ttg gta     1548
 Lys Thr Tyr Asp Thr Ser Phe Leu Asp Phe Leu Arg Arg Cys Leu Val
     480                 485                 490

 tgg gaa cct tct ctt cgc atg acc ccg gac cag gcc ctc aag cat gct     1596
 Trp Glu Pro Ser Leu Arg Met Thr Pro Asp Gln Ala Leu Lys His Ala
 495                 500                 505                 510

 tgg att cat cag tct cgg aac ctc aag cca cag ccc agg ccc cag acc     1644
 Trp Ile His Gln Ser Arg Asn Leu Lys Pro Gln Pro Arg Pro Gln Thr
                 515                 520                 525

 ctg agg aaa tcc aat tcc ttt ttc ccc tct gag aca agg aag gac aag     1692
 Leu Arg Lys Ser Asn Ser Phe Phe Pro Ser Glu Thr Arg Lys Asp Lys
             530                 535                 540

 gtt caa ggc tgt cat cac tcg agc aga aaa gat gag atc acc aaa gag     1740
 Val Gln Gly Cys His His Ser Ser Arg Lys Asp Glu Ile Thr Lys Glu
         545                 550                 555

 act aca gag aaa aca aaa gat agc ccc acg aag cat gtt cag cat tca     1788
 Thr Thr Glu Lys Thr Lys Asp Ser Pro Thr Lys His Val Gln His Ser
     560                 565                 570

 ggt gat cag cag gac tgt ctc cag cac gga gct gac act gtt cag ctg     1836
 Gly Asp Gln Gln Asp Cys Leu Gln His Gly Ala Asp Thr Val Gln Leu
 575                 580                 585                 590

 cct caa ctg gta gac gct ccc aag aag tca gag gca gct gtc ggg gcg     1884
 Pro Gln Leu Val Asp Ala Pro Lys Lys Ser Glu Ala Ala Val Gly Ala
                 595                 600                 605

 gag gtg tcc atg acc tcc cca gga cag agc aaa aac ttc tcc ctc aag     1932
 Glu Val Ser Met Thr Ser Pro Gly Gln Ser Lys Asn Phe Ser Leu Lys
             610                 615                 620

 aac aca aac gtt tta ccc cct att gta tga c ctttgctgag ggtatgtcct     1983
 Asn Thr Asn Val Leu Pro Pro Ile Val 
         625                 630

 gctcctttcc accagtgatt tgtattaaga cagcacttat attgtacaat acttcagact   2043

 g                                                                   2044




      <210> 158
      <211> 1079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (80)..(1036)

      <400> 158
 tttcgtgctg ccgcaggttc caccgcgctc caggtatttt tttttctgaa ggaaagctgc     60

 ttcctcatat gtttcaaga atg gct ctc cct atc att gta aaa tgg ggt gga     112
                      Met Ala Leu Pro Ile Ile Val Lys Trp Gly Gly
                        1               5                  10

 cag gag tat tca gtg acc aca ctt tca gaa gat gat act gtg ctc gat      160
 Gln Glu Tyr Ser Val Thr Thr Leu Ser Glu Asp Asp Thr Val Leu Asp
              15                  20                  25

 ctc aaa cag ttt ctc aag acc ctt aca gga gtt ctt cca gaa cgc caa      208
 Leu Lys Gln Phe Leu Lys Thr Leu Thr Gly Val Leu Pro Glu Arg Gln
          30                  35                  40

 aag tta ctt gga ctc aaa gtt aaa ggc aaa cct gca gaa aat gat gtt      256
 Lys Leu Leu Gly Leu Lys Val Lys Gly Lys Pro Ala Glu Asn Asp Val
      45                  50                  55

 aag ctt gga gct ctc aaa ctg aaa cca aat act aaa atc atg atg atg      304
 Lys Leu Gly Ala Leu Lys Leu Lys Pro Asn Thr Lys Ile Met Met Met
  60                  65                  70                  75

 gga act cgt gag gag agc ttg gaa gat gtc tta ggt cca ccc cct gac      352
 Gly Thr Arg Glu Glu Ser Leu Glu Asp Val Leu Gly Pro Pro Pro Asp
                  80                  85                  90

 aat gat gat gtt gtt aat gac ttt gat att gaa gat gaa gta gtt gaa      400
 Asn Asp Asp Val Val Asn Asp Phe Asp Ile Glu Asp Glu Val Val Glu
              95                 100                 105

 gta gaa aat agg gaa gaa aac cta ctg aaa att tct cgc aga gtg aaa      448
 Val Glu Asn Arg Glu Glu Asn Leu Leu Lys Ile Ser Arg Arg Val Lys
         110                 115                 120

 gag tac aaa gtg gaa att ttg aat cct ccc agg gaa ggg aaa aag ctt      496
 Glu Tyr Lys Val Glu Ile Leu Asn Pro Pro Arg Glu Gly Lys Lys Leu
     125                 130                 135

 ttg gtg cta gat gtt gat tat aca tta ttt gac cac agg tct tgt gca      544
 Leu Val Leu Asp Val Asp Tyr Thr Leu Phe Asp His Arg Ser Cys Ala
 140                 145                 150                 155

 gag act ggg gta gaa tta atg cgg cca tat ctt cat gaa ttt cta aca      592
 Glu Thr Gly Val Glu Leu Met Arg Pro Tyr Leu His Glu Phe Leu Thr
                 160                 165                 170

 tct gcc tat gaa gat tat gac att gtt att tgg tct gca aca aat atg      640
 Ser Ala Tyr Glu Asp Tyr Asp Ile Val Ile Trp Ser Ala Thr Asn Met
             175                 180                 185

 aag tgg att gaa gct aaa atg aaa gag ctg gga gtg agc aca aat gca      688
 Lys Trp Ile Glu Ala Lys Met Lys Glu Leu Gly Val Ser Thr Asn Ala
         190                 195                 200

 aat tat aag att act ttc atg ttg gat agt gct gct atg ata aca gta      736
 Asn Tyr Lys Ile Thr Phe Met Leu Asp Ser Ala Ala Met Ile Thr Val
     205                 210                 215

 cat act cca agg aga gga tta ata gac gta aag cct ctt ggt gtt ata      784
 His Thr Pro Arg Arg Gly Leu Ile Asp Val Lys Pro Leu Gly Val Ile
 220                 225                 230                 235

 tgg gga aag ttt tcg gag ttt tac agc aag aaa aac acc att atg ttt      832
 Trp Gly Lys Phe Ser Glu Phe Tyr Ser Lys Lys Asn Thr Ile Met Phe
                 240                 245                 250

 gat gac ata ggg aga aat ttt cta atg aac cca cag aat gga cta aag      880
 Asp Asp Ile Gly Arg Asn Phe Leu Met Asn Pro Gln Asn Gly Leu Lys
             255                 260                 265

 ata agg cct ttt atg aaa gcg cac cta aat cgt gat aaa gac aaa gaa      928
 Ile Arg Pro Phe Met Lys Ala His Leu Asn Arg Asp Lys Asp Lys Glu
         270                 275                 280

 ctt tta aaa tta act cag tac ctc aag gag ata gca aaa tta gat gac      976
 Leu Leu Lys Leu Thr Gln Tyr Leu Lys Glu Ile Ala Lys Leu Asp Asp
     285                 290                 295

 ttt ttg gat cta aat cac aaa tat tgg gaa aga tat ctc tca aag aag     1024
 Phe Leu Asp Leu Asn His Lys Tyr Trp Glu Arg Tyr Leu Ser Lys Lys
 300                 305                 310                 315

 caa gga cag tag tta caagttatac tggcagttat tgaagatact taagatccaa     1079
 Gln Gly Gln 






      <210> 159
      <211> 2714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (928)..(1785)

      <400> 159
 acccccttcc cagaccctgg cccgcagccg gatcactccg ggcgcgctgc cgatcacgtg     60

 gcgaagcggt gctccccagc gccgtggctg cgcgcccatt ggtcggcggc tggagtcccg    120

 ggcgcgccca ttggcggggc tggaacactc taggtagctg gccccaggga gctgttgctt    180

 cagcgtggag agggcgatcc agggaccgca gctgggaagc gcctcccggg cccacgtgct    240

 ccaccgcgct gctgggcccg gctgcgaccg tgacccggga gctgcggctg cggcggctga    300

 tccctttacc acctgttgtt ctggcttcga aactagcaca agttcccagc cccgggtccc    360

 gagaggtctg gagacttctc caaagttggg tagtggggtt tggagcttaa ggacaagccg    420

 cttcgtctct ctccgggcct tattttccct ataaaacgcg aggaaataca cttggtaggc    480

 tctcaggcca ccgagggcga cgggacctag cacgatcccc gtcccgggct ggcggaggcc    540

 aggcggccgc gcgggggtgc tggtgtcgcg ctgcttgctc cggccggggt tgcccctttg    600

 ccggccccgc ccgggtgcga taacgggctc ctcctcctcg tcgtcttcct cccaccgccg    660

 acatctccgg gaacccagcc caggccctgc ctcccggaca caccgacgct cacgtagtcg    720

 cgcttgccac aaccctgcgg gctctccgat gcggcgagcg agcttgcaca tctcagttgc    780

 taggagtact tctgcatggc ggcagccatc cctgtcactc acgtagtcgc gcttgccaca    840

 accctgcggg ctctccgatg cggcgagcga gctggggagg gggcttctcc gcggcccaaa    900

 agggttctag cctgttcatc tagcccc    atg atg gct gtg gac atc gag tac     951
                                  Met Met Ala Val Asp Ile Glu Tyr
                                    1               5

 aga tac aac tgc atg gct cct tcc ttg cgc caa gag agg ttt gcc ttt      999
 Arg Tyr Asn Cys Met Ala Pro Ser Leu Arg Gln Glu Arg Phe Ala Phe
      10                  15                  20

 aag atc tca cca aag ccc agc aaa cca ctg agg cct tgt att cag ctg     1047
 Lys Ile Ser Pro Lys Pro Ser Lys Pro Leu Arg Pro Cys Ile Gln Leu
  25                  30                  35                  40

 agc agc aag aat gaa gcc agt gga atg gtg gcc ccg gct gtc cag gag     1095
 Ser Ser Lys Asn Glu Ala Ser Gly Met Val Ala Pro Ala Val Gln Glu
                  45                  50                  55

 aag aag gtg aaa aag cgg gtg tcc ttc gca gac aac cag ggg ctg gcc     1143
 Lys Lys Val Lys Lys Arg Val Ser Phe Ala Asp Asn Gln Gly Leu Ala
              60                  65                  70

 ctg aca atg gtc aaa gtg ttc tcg gaa ttc gat gac ccg cta gat atg     1191
 Leu Thr Met Val Lys Val Phe Ser Glu Phe Asp Asp Pro Leu Asp Met
          75                  80                  85

 cca ttc aac atc acc gag ctc cta gac aac att gtg agc ttg acg aca     1239
 Pro Phe Asn Ile Thr Glu Leu Leu Asp Asn Ile Val Ser Leu Thr Thr
      90                  95                 100

 gca gag agc gag agc ttt gtt ctg gat ttt tcc cag ccc tct gca gat     1287
 Ala Glu Ser Glu Ser Phe Val Leu Asp Phe Ser Gln Pro Ser Ala Asp
 105                 110                 115                 120

 tac tta gac ttt aga aat cga ctt cag gcc gac cac gtc tgc ctt gag     1335
 Tyr Leu Asp Phe Arg Asn Arg Leu Gln Ala Asp His Val Cys Leu Glu
                 125                 130                 135

 aac tgt gtg ctc aag gac aag gcc att gca ggc act gtg aag gtt cag     1383
 Asn Cys Val Leu Lys Asp Lys Ala Ile Ala Gly Thr Val Lys Val Gln
             140                 145                 150

 aac ctc gca ttt gag aag acc gtg aaa ata agg atg acg ttc gac acc     1431
 Asn Leu Ala Phe Glu Lys Thr Val Lys Ile Arg Met Thr Phe Asp Thr
         155                 160                 165

 tgg aag agc tac aca gac ttt cct tgt cag tac gtg aag gac act tat     1479
 Trp Lys Ser Tyr Thr Asp Phe Pro Cys Gln Tyr Val Lys Asp Thr Tyr
     170                 175                 180

 gcc ggt tca gac agg gac acg ttc tcc ttc gac atc agc ttg ccc gag     1527
 Ala Gly Ser Asp Arg Asp Thr Phe Ser Phe Asp Ile Ser Leu Pro Glu
 185                 190                 195                 200

 aag att cag tct tat gaa aga atg gag ttt gct gtg tac tac gag tgc     1575
 Lys Ile Gln Ser Tyr Glu Arg Met Glu Phe Ala Val Tyr Tyr Glu Cys
                 205                 210                 215

 aat gga cag acg tac tgg gac agc aac aga ggc aag aac tat agg atc     1623
 Asn Gly Gln Thr Tyr Trp Asp Ser Asn Arg Gly Lys Asn Tyr Arg Ile
             220                 225                 230

 atc cgg gct gag tta aaa tct acc cag gga atg acc aag ccc cac agt     1671
 Ile Arg Ala Glu Leu Lys Ser Thr Gln Gly Met Thr Lys Pro His Ser
         235                 240                 245

 gga ccg gat ttg gga ata tcc ttt gac cag ttc gga agc cct cgg tgt     1719
 Gly Pro Asp Leu Gly Ile Ser Phe Asp Gln Phe Gly Ser Pro Arg Cys
     250                 255                 260

 tcc tat ggt ctg ttt cca gag tgg cca agt tac tta gga tat gaa aag     1767
 Ser Tyr Gly Leu Phe Pro Glu Trp Pro Ser Tyr Leu Gly Tyr Glu Lys
 265                 270                 275                 280

 cta ggg ccc tac tac tag tgactg caggtgacag ggcgtggcgg agctgccaca     1821
 Leu Gly Pro Tyr Tyr 
                 285

 gacacaccta gctctgctca ctgtgcagtg gagatggaag gccagggagg agcaacgtgg   1881

 aacttccatg aggccccgtt tgggaaaata aaaggatcct cttcacttct ttcttaaaca   1941

 gcaaatccag ccaggttcag attacacaac cagtgtctca ctcaaaggag cagtggtggc   2001

 tggcgcgctt tcgcactgtg gcagccacga gagtctgtgc acgtctgtgc tggaaagggt   2061

 atggatggga atcaagccta tgccagtgct gatgaagctg gaggagtctc tcctctgctc   2121

 tccactcaga tgtgggacat cagtcgccaa aagccactca gccccagcca cctcgcgtga   2181

 gaccctcact gttcattgtg ttcatctttg ggtgctctct gccagccagg cctttcctgc   2241

 aagctgctgt gcttccccgt ccacgtgtat ctctgctgtg acacactgac ctgacgcaca   2301

 tttccagtgc agctgcagaa gagaaatggg attggctctt gttttctgca agttcatgtt   2361

 ttgcatttta tgttcttcca caattgatct gatgttcagg aaaagataat aaaggcaaat   2421

 tagttagtgg ttgagacagg catttcctcc tcccgcttct tgaccccaca gatgtattcc   2481

 agcagagagc aacacaccag tcatcaaaac ccactggctc ctgtgcggtg tcacagattg   2541

 cagggttctg acaaggcagg acagtcaaga gtggggacac tttcagcttc tacttttgcc   2601

 ttctaggggg agctttctaa gtccccacat ttaccccgag tcaccggaaa aatctgattt   2661

 ttcccccgaa agctcaatga ctttaacgtg cttggctggt ttgtctcatt ctt          2714




      <210> 160
      <211> 1701
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (40)..(1530)

      <400> 160
 gtggagctgc ggctgcccat ctccgagacg ctctcccag   atg aac cgg gac cag      54
                                              Met Asn Arg Asp Gln
                                                1               5

 ctg cag aag ttc gtg cag tac ctc atc agc gcc cat cac act gag gtg      102
 Leu Gln Lys Phe Val Gln Tyr Leu Ile Ser Ala His His Thr Glu Val
                  10                  15                  20

 ctg ccc act gct cag cgc ttg gct gat gag atc ctc ctg ctg ggc tcc      150
 Leu Pro Thr Ala Gln Arg Leu Ala Asp Glu Ile Leu Leu Leu Gly Ser
              25                  30                  35

 gag atc aac ttg gtg aat gga gtc gtg gag tgg gtt cgg cca cgt gga      198
 Glu Ile Asn Leu Val Asn Gly Val Val Glu Trp Val Arg Pro Arg Gly
          40                  45                  50

 atc cgc gtc ctg gga acc cgt gga atc cgc gtc ctg gga acc cgt gga      246
 Ile Arg Val Leu Gly Thr Arg Gly Ile Arg Val Leu Gly Thr Arg Gly
      55                  60                  65

 atc cgc gtc ctg gga acc cgt gga atc cgc gtc ctg gga acc cgt gga      294
 Ile Arg Val Leu Gly Thr Arg Gly Ile Arg Val Leu Gly Thr Arg Gly
  70                  75                  80                  85

 atc cgc gtc ctg gga acc cgt gga atc cgc gtc ctg gga acc cgt gga      342
 Ile Arg Val Leu Gly Thr Arg Gly Ile Arg Val Leu Gly Thr Arg Gly
                  90                  95                 100

 atc cgc gtc ctg gga acc cgt gga atc ggg ttg gat gcg cat ctc cct      390
 Ile Arg Val Leu Gly Thr Arg Gly Ile Gly Leu Asp Ala His Leu Pro
             105                 110                 115

 ctg agt tgc gct ggg ctt ggc tgc tgc acc atg acc ctg gag gcg atc      438
 Leu Ser Cys Ala Gly Leu Gly Cys Cys Thr Met Thr Leu Glu Ala Ile
         120                 125                 130

 cgc tac tcg cgg ggc tcc ctg cag atc cta gac cag ctg ctg ctg ccc      486
 Arg Tyr Ser Arg Gly Ser Leu Gln Ile Leu Asp Gln Leu Leu Leu Pro
     135                 140                 145

 aag cag agc cgc tac gag gcg gtg ggc tcg gtg cac cag gcc tgg gag      534
 Lys Gln Ser Arg Tyr Glu Ala Val Gly Ser Val His Gln Ala Trp Glu
 150                 155                 160                 165

 gcc atc cgc gcc atg aag gtg cgg ggc gcc ccg gcc ata gcc ctg gtg      582
 Ala Ile Arg Ala Met Lys Val Arg Gly Ala Pro Ala Ile Ala Leu Val
                 170                 175                 180

 ggc tgt ctc agc ctc gcc gtg gag ctg cag gcg ggc gcc ggg gga ccg      630
 Gly Cys Leu Ser Leu Ala Val Glu Leu Gln Ala Gly Ala Gly Gly Pro
             185                 190                 195

 gga ctc gcc gcg ctc gtg gcc ttc gtg cgc gac aag ctg agc ttc ctc      678
 Gly Leu Ala Ala Leu Val Ala Phe Val Arg Asp Lys Leu Ser Phe Leu
         200                 205                 210

 gtc acc gcc cgg ccc acc gct gtc aac atg gcc cgc gcc gcc cgc gac      726
 Val Thr Ala Arg Pro Thr Ala Val Asn Met Ala Arg Ala Ala Arg Asp
     215                 220                 225

 ctg gct gat gtt gca gcc cgg gag gcc gaa cgg gag ggc gct acg gaa      774
 Leu Ala Asp Val Ala Ala Arg Glu Ala Glu Arg Glu Gly Ala Thr Glu
 230                 235                 240                 245

 gag gcg gtc cgg gag aga gtg atc tgc tgc acc gag gac atg ctg gag      822
 Glu Ala Val Arg Glu Arg Val Ile Cys Cys Thr Glu Asp Met Leu Glu
                 250                 255                 260

 aaa gac ctc aga gac aac cga agc att ggg gac cta gga gcc cgc cac      870
 Lys Asp Leu Arg Asp Asn Arg Ser Ile Gly Asp Leu Gly Ala Arg His
             265                 270                 275

 ctc ctg gag cgg gtg gcc ccc agc ggt ggc aag gtg act gtg ctg acc      918
 Leu Leu Glu Arg Val Ala Pro Ser Gly Gly Lys Val Thr Val Leu Thr
         280                 285                 290

 cac tgt aac act ggt gct ctg gcc acc gct ggc tat ggt aca gcc cta      966
 His Cys Asn Thr Gly Ala Leu Ala Thr Ala Gly Tyr Gly Thr Ala Leu
     295                 300                 305

 ggt gtg att cgc tca ctg cac agc ctg ggc cgc ctg gag cat gcc ttc     1014
 Gly Val Ile Arg Ser Leu His Ser Leu Gly Arg Leu Glu His Ala Phe
 310                 315                 320                 325

 tgc aca gag acc cgg ccc tac aac cag gga gcc cgg ctg acg gcc ttt     1062
 Cys Thr Glu Thr Arg Pro Tyr Asn Gln Gly Ala Arg Leu Thr Ala Phe
                 330                 335                 340

 gag ctg gtc tat gag cag atc ccc gcc acc ctt atc acc gac agc atg     1110
 Glu Leu Val Tyr Glu Gln Ile Pro Ala Thr Leu Ile Thr Asp Ser Met
             345                 350                 355

 gtg gct gct gcc atg gcc cat agg ggc gtg tca gct gtg gtc gtg gga     1158
 Val Ala Ala Ala Met Ala His Arg Gly Val Ser Ala Val Val Val Gly
         360                 365                 370

 gct gac cgc gtg gtt gcc aac ggc gac aca gcc aac aag gtg ggc acc     1206
 Ala Asp Arg Val Val Ala Asn Gly Asp Thr Ala Asn Lys Val Gly Thr
     375                 380                 385

 tac cag ctg gcc att gtc gcc aag cac cat ggc att ccc ttc tac gtg     1254
 Tyr Gln Leu Ala Ile Val Ala Lys His His Gly Ile Pro Phe Tyr Val
 390                 395                 400                 405

 gct gcc ccc agc tct tca tgt gac ctc cgt ctg gag acc ggc aag gag     1302
 Ala Ala Pro Ser Ser Ser Cys Asp Leu Arg Leu Glu Thr Gly Lys Glu
                 410                 415                 420

 atc att att gaa gag cga ccg ggc cag gag ctg acc gat gtt aat ggg     1350
 Ile Ile Ile Glu Glu Arg Pro Gly Gln Glu Leu Thr Asp Val Asn Gly
             425                 430                 435

 gtc cgg att gca gca cct ggg att gga gtt tgg aat cct gcc ttc gat     1398
 Val Arg Ile Ala Ala Pro Gly Ile Gly Val Trp Asn Pro Ala Phe Asp
         440                 445                 450

 gtc acc ccc cac gac ctc atc act ggt ggc atc atc aca gaa ctg ggg     1446
 Val Thr Pro His Asp Leu Ile Thr Gly Gly Ile Ile Thr Glu Leu Gly
     455                 460                 465

 gtc ttt gcc cct gag gag ctc cgg aca gcc cta acc acc acc atc tct     1494
 Val Phe Ala Pro Glu Glu Leu Arg Thr Ala Leu Thr Thr Thr Ile Ser
 470                 475                 480                 485

 tcc agg gat gga acc cta gat gga ccc cag atg taa ccaa ctcagctctc     1544
 Ser Arg Asp Gly Thr Leu Asp Gly Pro Gln Met 
                 490                 495

 cctagcctgc ctctctaggt ttttcaatac atttcttgaa tggctaccca aaagctgacc   1604

 gtccagcccc tgaccacact tgttcctagt gcagggagct cagacagggc cttccatcta   1664

 gagcccagca cctagagcca ggctgcccag attcaaa                            1701




      <210> 161
      <211> 7543
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (109)..(6474)

      <400> 161
 caccctaact ctatgattcc tgcttttgac caaaggaatg ggttacgtgt tatctacaaa     60

 cttctggcat cgaaaagtga aggaatcagg gtacaagctc ttaaggca atg ggt tat     117
                                                      Met Gly Tyr
                                                        1

 ttt tta aaa cat ctg gcc cca aag agg aaa gca gaa gtc atg ctt gga      165
 Phe Leu Lys His Leu Ala Pro Lys Arg Lys Ala Glu Val Met Leu Gly
       5                  10                  15

 cat gga ttg ttt tca ttg cta gct gaa agg ctc atg ctt cag aca aat      213
 His Gly Leu Phe Ser Leu Leu Ala Glu Arg Leu Met Leu Gln Thr Asn
  20                  25                  30                  35

 tta atc aca atg acc aca tat aat gtg ctg ttt gag att ctt ata gaa      261
 Leu Ile Thr Met Thr Thr Tyr Asn Val Leu Phe Glu Ile Leu Ile Glu
                  40                  45                  50

 cag att ggt act cag gtg ata cat aaa cag cat cca gat cct gat tct      309
 Gln Ile Gly Thr Gln Val Ile His Lys Gln His Pro Asp Pro Asp Ser
              55                  60                  65

 tca gtg aag ata caa aac cct cag ata cta aaa gta att gcg acc cta      357
 Ser Val Lys Ile Gln Asn Pro Gln Ile Leu Lys Val Ile Ala Thr Leu
          70                  75                  80

 ctt cga aat tct ccc cag tgc cca gag agc atg gag gtt cgc aga gcc      405
 Leu Arg Asn Ser Pro Gln Cys Pro Glu Ser Met Glu Val Arg Arg Ala
      85                  90                  95

 ttt ctt tct gac atg att aaa ctt ttt aat aac agt aga gaa aac agg      453
 Phe Leu Ser Asp Met Ile Lys Leu Phe Asn Asn Ser Arg Glu Asn Arg
 100                 105                 110                 115

 agg agc ttg cta caa tgc tct gtg tgg caa gaa tgg atg ctt tct ctc      501
 Arg Ser Leu Leu Gln Cys Ser Val Trp Gln Glu Trp Met Leu Ser Leu
                 120                 125                 130

 tgc tat ttt aat cct aag aat tca gat gag caa aag ata aca gaa atg      549
 Cys Tyr Phe Asn Pro Lys Asn Ser Asp Glu Gln Lys Ile Thr Glu Met
             135                 140                 145

 gta tac gcc ata ttc aga atc ctg ctt tac cat gca gtc aaa tat gag      597
 Val Tyr Ala Ile Phe Arg Ile Leu Leu Tyr His Ala Val Lys Tyr Glu
         150                 155                 160

 tgg ggt ggc tgg cgt gta tgg gta gac act tta tca atc act cat tca      645
 Trp Gly Gly Trp Arg Val Trp Val Asp Thr Leu Ser Ile Thr His Ser
     165                 170                 175

 aag gtc act ttt gaa ata cac aaa gaa aac ctt gcc aat ata ttt agg      693
 Lys Val Thr Phe Glu Ile His Lys Glu Asn Leu Ala Asn Ile Phe Arg
 180                 185                 190                 195

 gaa cag caa gga aaa gtt gat gaa gaa ata ggg ctg tgt tct tca act      741
 Glu Gln Gln Gly Lys Val Asp Glu Glu Ile Gly Leu Cys Ser Ser Thr
                 200                 205                 210

 tca gtt caa gca gct tct ggc att aga agg gat att aat gtt tca gta      789
 Ser Val Gln Ala Ala Ser Gly Ile Arg Arg Asp Ile Asn Val Ser Val
             215                 220                 225

 gga tcc cag caa cca gat acg aag gat tct cct gtc tgt cct cat ttc      837
 Gly Ser Gln Gln Pro Asp Thr Lys Asp Ser Pro Val Cys Pro His Phe
         230                 235                 240

 acc aca aat ggt aat gaa aat tca agt ata gag aag aca agt tca cta      885
 Thr Thr Asn Gly Asn Glu Asn Ser Ser Ile Glu Lys Thr Ser Ser Leu
     245                 250                 255

 gaa tct gca tct aat att gaa ctg caa act act aat aca tct tat gaa      933
 Glu Ser Ala Ser Asn Ile Glu Leu Gln Thr Thr Asn Thr Ser Tyr Glu
 260                 265                 270                 275

 gaa atg aaa gct gag caa gaa aat cag gag tta cca gat gaa ggc act      981
 Glu Met Lys Ala Glu Gln Glu Asn Gln Glu Leu Pro Asp Glu Gly Thr
                 280                 285                 290

 ttg gaa gaa aca ctg aca aat gag aca agg aat gca gat gat tta gaa     1029
 Leu Glu Glu Thr Leu Thr Asn Glu Thr Arg Asn Ala Asp Asp Leu Glu
             295                 300                 305

 gta tct tct gac ata ata gaa gct gtg gct att tcc tct aat tct ttt     1077
 Val Ser Ser Asp Ile Ile Glu Ala Val Ala Ile Ser Ser Asn Ser Phe
         310                 315                 320

 ata aca act ggc aaa gat tca atg act gtc agt gaa gta act gct tct     1125
 Ile Thr Thr Gly Lys Asp Ser Met Thr Val Ser Glu Val Thr Ala Ser
     325                 330                 335

 ata agt tct cct tca gaa gag gat gcc tca gag atg cca gaa ttc ttg     1173
 Ile Ser Ser Pro Ser Glu Glu Asp Ala Ser Glu Met Pro Glu Phe Leu
 340                 345                 350                 355

 gat aaa tct ata gta gag gaa gag gaa gat gat gat tat gtg gaa ctg     1221
 Asp Lys Ser Ile Val Glu Glu Glu Glu Asp Asp Asp Tyr Val Glu Leu
                 360                 365                 370

 aaa gta gaa ggc agt cct act gag gaa gct aat cta ccc aca gag ctc     1269
 Lys Val Glu Gly Ser Pro Thr Glu Glu Ala Asn Leu Pro Thr Glu Leu
             375                 380                 385

 caa gat aac agt ttg tct cca gct gca tct gaa gcc ggt gaa aaa ctg     1317
 Gln Asp Asn Ser Leu Ser Pro Ala Ala Ser Glu Ala Gly Glu Lys Leu
         390                 395                 400

 gac atg ttt ggt aat gat gac aaa tta ata ttt caa gaa gga aaa cct     1365
 Asp Met Phe Gly Asn Asp Asp Lys Leu Ile Phe Gln Glu Gly Lys Pro
     405                 410                 415

 gtt act gaa aag caa act gat act gaa act caa gat tct aaa gat tct     1413
 Val Thr Glu Lys Gln Thr Asp Thr Glu Thr Gln Asp Ser Lys Asp Ser
 420                 425                 430                 435

 gga att cag act atg aca gca tca ggg tct tca gct atg tca cca gaa     1461
 Gly Ile Gln Thr Met Thr Ala Ser Gly Ser Ser Ala Met Ser Pro Glu
                 440                 445                 450

 act act gtt tcc caa ata gct gta gaa tca gac ctt ggt cag atg ctg     1509
 Thr Thr Val Ser Gln Ile Ala Val Glu Ser Asp Leu Gly Gln Met Leu
             455                 460                 465

 gag gaa ggg aag aaa gca act aac ctc act aga gaa acc aaa tta att     1557
 Glu Glu Gly Lys Lys Ala Thr Asn Leu Thr Arg Glu Thr Lys Leu Ile
         470                 475                 480

 aat gat tgt cat ggt agt gtc tct gag gct tct tct gag caa aag att     1605
 Asn Asp Cys His Gly Ser Val Ser Glu Ala Ser Ser Glu Gln Lys Ile
     485                 490                 495

 gcg aag ttg gat gtt tcc aat gtt gct aca gat act gag agg ctg gag     1653
 Ala Lys Leu Asp Val Ser Asn Val Ala Thr Asp Thr Glu Arg Leu Glu
 500                 505                 510                 515

 ttg aag gcc agt ccc aac gtg gaa gca cct caa cct cat cga cat gtg     1701
 Leu Lys Ala Ser Pro Asn Val Glu Ala Pro Gln Pro His Arg His Val
                 520                 525                 530

 ctt gag ata tca agg caa cat gag cag cca ggg caa gga ata gca cca     1749
 Leu Glu Ile Ser Arg Gln His Glu Gln Pro Gly Gln Gly Ile Ala Pro
             535                 540                 545

 gat gca gtt aat gga caa agg agg gat tcc aga tct act gtg ttt cgt     1797
 Asp Ala Val Asn Gly Gln Arg Arg Asp Ser Arg Ser Thr Val Phe Arg
         550                 555                 560

 att cct gag ttc aac tgg tct cag atg cat caa cgt ttg ctc act gat     1845
 Ile Pro Glu Phe Asn Trp Ser Gln Met His Gln Arg Leu Leu Thr Asp
     565                 570                 575

 cta tta ttt tca ata gaa aca gat ata cag atg tgg aga agc cat tca     1893
 Leu Leu Phe Ser Ile Glu Thr Asp Ile Gln Met Trp Arg Ser His Ser
 580                 585                 590                 595

 aca aag aca gtt atg gac ttc gtg aat agc agt gat aat gtc atc ttt     1941
 Thr Lys Thr Val Met Asp Phe Val Asn Ser Ser Asp Asn Val Ile Phe
                 600                 605                 610

 gta cac aac aca att cat ctc atc tct caa gtg atg gac aat atg gtc     1989
 Val His Asn Thr Ile His Leu Ile Ser Gln Val Met Asp Asn Met Val
             615                 620                 625

 atg gct tgt ggg ggt ata ctg cca ttg ctt tca gct gct aca tcg gct     2037
 Met Ala Cys Gly Gly Ile Leu Pro Leu Leu Ser Ala Ala Thr Ser Ala
         630                 635                 640

 aca cat gag ctg gaa aat att gaa cct act caa ggc ctt tca ata gaa     2085
 Thr His Glu Leu Glu Asn Ile Glu Pro Thr Gln Gly Leu Ser Ile Glu
     645                 650                 655

 gcc tct gtg aca ttt ttg cag agg cta att agc ctt gtg gat gtg ctt     2133
 Ala Ser Val Thr Phe Leu Gln Arg Leu Ile Ser Leu Val Asp Val Leu
 660                 665                 670                 675

 ata ttt gca agt tct ctt ggc ttt act gaa att gaa gct gaa aaa agt     2181
 Ile Phe Ala Ser Ser Leu Gly Phe Thr Glu Ile Glu Ala Glu Lys Ser
                 680                 685                 690

 atg tca tct gga gga att ttg cgg cag tgt ctc cga cta gtt tgt gca     2229
 Met Ser Ser Gly Gly Ile Leu Arg Gln Cys Leu Arg Leu Val Cys Ala
             695                 700                 705

 gtc gca gta agg aat tgc ttg gag tgt caa cag cat tca caa ctg aaa     2277
 Val Ala Val Arg Asn Cys Leu Glu Cys Gln Gln His Ser Gln Leu Lys
         710                 715                 720

 act agg gga gat aaa gcc ttg aaa cca atg cat agc ctt att cct tta     2325
 Thr Arg Gly Asp Lys Ala Leu Lys Pro Met His Ser Leu Ile Pro Leu
     725                 730                 735

 ggg aaa tct gca gcg aag agc cca gtg gac att gtg act ggc ggt ata     2373
 Gly Lys Ser Ala Ala Lys Ser Pro Val Asp Ile Val Thr Gly Gly Ile
 740                 745                 750                 755

 tct cca gta aga gat ctt gac agg ctt cta cag gac atg gat att aat     2421
 Ser Pro Val Arg Asp Leu Asp Arg Leu Leu Gln Asp Met Asp Ile Asn
                 760                 765                 770

 cgg ctt agg gca gtt gtt ttc aga gac ata gag gat agc aaa caa gct     2469
 Arg Leu Arg Ala Val Val Phe Arg Asp Ile Glu Asp Ser Lys Gln Ala
             775                 780                 785

 caa ttt tta gcc ttg gca gta gta tac ttt atc tct gtt ctt atg gtc     2517
 Gln Phe Leu Ala Leu Ala Val Val Tyr Phe Ile Ser Val Leu Met Val
         790                 795                 800

 tcc aag tac aga gac att ttg gaa ccc caa aat gaa agg cat agc cag     2565
 Ser Lys Tyr Arg Asp Ile Leu Glu Pro Gln Asn Glu Arg His Ser Gln
     805                 810                 815

 tca tgt aca gaa act ggc agt gaa aat gag aat gta tca ctt tct gaa     2613
 Ser Cys Thr Glu Thr Gly Ser Glu Asn Glu Asn Val Ser Leu Ser Glu
 820                 825                 830                 835

 atc aca cca gca gca ttc agc act tta act acg gca tca gtg gaa gaa     2661
 Ile Thr Pro Ala Ala Phe Ser Thr Leu Thr Thr Ala Ser Val Glu Glu
                 840                 845                 850

 tct gaa agc aca tca tct gct cga agg agg gac tca ggc att ggg gaa     2709
 Ser Glu Ser Thr Ser Ser Ala Arg Arg Arg Asp Ser Gly Ile Gly Glu
             855                 860                 865

 gaa aca gcc act ggt tta gga agc cat gtg gaa gta act cct cac aca     2757
 Glu Thr Ala Thr Gly Leu Gly Ser His Val Glu Val Thr Pro His Thr
         870                 875                 880

 gca cct cct ggt gtc agt gca ggc cca gat gca atc agc gag gtg cta     2805
 Ala Pro Pro Gly Val Ser Ala Gly Pro Asp Ala Ile Ser Glu Val Leu
     885                 890                 895

 tct act ctt tct tta gaa gtc aat aag tct ccg gaa acc aaa aat gat     2853
 Ser Thr Leu Ser Leu Glu Val Asn Lys Ser Pro Glu Thr Lys Asn Asp
 900                 905                 910                 915

 aga gga aat gac ttg gac act aag gct aca ccg tca gtt tca gtt tca     2901
 Arg Gly Asn Asp Leu Asp Thr Lys Ala Thr Pro Ser Val Ser Val Ser
                 920                 925                 930

 aaa aac gtc aat gtg aaa gac att ctc cga agc ttg gtt aac ata cca     2949
 Lys Asn Val Asn Val Lys Asp Ile Leu Arg Ser Leu Val Asn Ile Pro
             935                 940                 945

 gca gat gga gtc aca gtg gat cct gcc ctt ctg cca cca gcc tgc ctt     2997
 Ala Asp Gly Val Thr Val Asp Pro Ala Leu Leu Pro Pro Ala Cys Leu
         950                 955                 960

 gga gcc ctt ggt gat cta tct gtg gaa caa ccc gtg cag ttc aga tct     3045
 Gly Ala Leu Gly Asp Leu Ser Val Glu Gln Pro Val Gln Phe Arg Ser
     965                 970                 975

 ttt gac aga agt gtc att gtt gca gca aaa aag tca gca gtc tca cct     3093
 Phe Asp Arg Ser Val Ile Val Ala Ala Lys Lys Ser Ala Val Ser Pro
 980                 985                 990                 995

 tcc acc ttt aat aca agc ata cct acc aat gct gtc agt gtg gtt tcc     3141
 Ser Thr Phe Asn Thr Ser Ile Pro Thr Asn Ala Val Ser Val Val Ser
                1000                1005                1010

 tca gta gat tca gcc caa gcc tca gat atg gga gga gaa tca cca ggc     3189
 Ser Val Asp Ser Ala Gln Ala Ser Asp Met Gly Gly Glu Ser Pro Gly
            1015                1020                1025

 agt aga tca tct aat gca aaa ttg ccc tca gtt cca aca gtt gat tca     3237
 Ser Arg Ser Ser Asn Ala Lys Leu Pro Ser Val Pro Thr Val Asp Ser
        1030                1035                1040

 gtt tca caa gat ccg gtt tca aat atg agt att aca gag agg ctt gaa     3285
 Val Ser Gln Asp Pro Val Ser Asn Met Ser Ile Thr Glu Arg Leu Glu
    1045                1050                1055

 cac gct ttg gaa aag gca gct cct ctc ctt cgt gag att ttt gtg gat     3333
 His Ala Leu Glu Lys Ala Ala Pro Leu Leu Arg Glu Ile Phe Val Asp
1060                1065                1070                1075

 ttt gca cct ttt ctt tct cgg aca ctt ttg ggt agc cat gga caa gaa     3381
 Phe Ala Pro Phe Leu Ser Arg Thr Leu Leu Gly Ser His Gly Gln Glu
                1080                1085                1090

 ctg ctt ata gaa gga aca agt ctg gtt tgc atg aag tcg agt agt tca     3429
 Leu Leu Ile Glu Gly Thr Ser Leu Val Cys Met Lys Ser Ser Ser Ser
            1095                1100                1105

 gtc gtg gaa ttg gtt atg cta ctg tgt tct cag gag tgg caa aat tct     3477
 Val Val Glu Leu Val Met Leu Leu Cys Ser Gln Glu Trp Gln Asn Ser
        1110                1115                1120

 att cag aag aat gca ggc ctt gct ttt atc gaa ctt gtc aat gaa gga     3525
 Ile Gln Lys Asn Ala Gly Leu Ala Phe Ile Glu Leu Val Asn Glu Gly
    1125                1130                1135

 agg ttg ctt agc cag aca atg aag gat cat cta gta aga gta gca aat     3573
 Arg Leu Leu Ser Gln Thr Met Lys Asp His Leu Val Arg Val Ala Asn
1140                1145                1150                1155

 gaa gct gaa ttt atc ctg agc agg cag aga gca gaa gat att cac aga     3621
 Glu Ala Glu Phe Ile Leu Ser Arg Gln Arg Ala Glu Asp Ile His Arg
                1160                1165                1170

 cat gcg gaa ttt gag tca ctg tgt gcc cag tat tct gca gac aaa cga     3669
 His Ala Glu Phe Glu Ser Leu Cys Ala Gln Tyr Ser Ala Asp Lys Arg
            1175                1180                1185

 gaa gat gag aag atg tgt gat cat ttg ata aga gca gca aaa tat cgt     3717
 Glu Asp Glu Lys Met Cys Asp His Leu Ile Arg Ala Ala Lys Tyr Arg
        1190                1195                1200

 gac cac gtg aca gca act caa cta atc cag aaa att atc aac att ctc     3765
 Asp His Val Thr Ala Thr Gln Leu Ile Gln Lys Ile Ile Asn Ile Leu
    1205                1210                1215

 aca gac aag cat gga gcc tgg gga aat tct gca gtg agt cgt cct ctt     3813
 Thr Asp Lys His Gly Ala Trp Gly Asn Ser Ala Val Ser Arg Pro Leu
1220                1225                1230                1235

 gag ttc tgg cgc ctt gac tac tgg gaa gat gac ttg cgg cgc cgg cga     3861
 Glu Phe Trp Arg Leu Asp Tyr Trp Glu Asp Asp Leu Arg Arg Arg Arg
                1240                1245                1250

 cga ttt gtg cgt aac cct cta gga tcg aca cat cct gaa gcg aca cta     3909
 Arg Phe Val Arg Asn Pro Leu Gly Ser Thr His Pro Glu Ala Thr Leu
            1255                1260                1265

 aaa aca gcc gtg gaa cat gtg tgc att ttt aaa ttg aga gag aac agc     3957
 Lys Thr Ala Val Glu His Val Cys Ile Phe Lys Leu Arg Glu Asn Ser
        1270                1275                1280

 aaa gcc aca gat gaa gat atc ctt gct aaa gga aaa cag tcc atc agg     4005
 Lys Ala Thr Asp Glu Asp Ile Leu Ala Lys Gly Lys Gln Ser Ile Arg
    1285                1290                1295

 agt cag gct tta gga aat cag aac tca gaa aac gag atc ctc ctg gaa     4053
 Ser Gln Ala Leu Gly Asn Gln Asn Ser Glu Asn Glu Ile Leu Leu Glu
1300                1305                1310                1315

 ggc gat gat gat act ctg tca tcc gtg gat gag aaa gat tta gag aat     4101
 Gly Asp Asp Asp Thr Leu Ser Ser Val Asp Glu Lys Asp Leu Glu Asn
                1320                1325                1330

 ctt gcc ggt cct gtt agc ctg agc aca cca gct cag ctt gtg gcc ccc     4149
 Leu Ala Gly Pro Val Ser Leu Ser Thr Pro Ala Gln Leu Val Ala Pro
            1335                1340                1345

 tct gtt gta gta aag ggc act ctt tct gtc acc tcc tcc gaa ctc tat     4197
 Ser Val Val Val Lys Gly Thr Leu Ser Val Thr Ser Ser Glu Leu Tyr
        1350                1355                1360

 ttt gag gtg gat gaa gag gat cct aac ttc aaa aaa atc gac ccc aag     4245
 Phe Glu Val Asp Glu Glu Asp Pro Asn Phe Lys Lys Ile Asp Pro Lys
    1365                1370                1375

 atc ttg gca tat aca gaa ggg ctg cat gga aaa tgg ctg ttc aca gag     4293
 Ile Leu Ala Tyr Thr Glu Gly Leu His Gly Lys Trp Leu Phe Thr Glu
1380                1385                1390                1395

 ata cga tca atc ttt tct cgt cgt tat ctt ttg caa aat aca gcc ctg     4341
 Ile Arg Ser Ile Phe Ser Arg Arg Tyr Leu Leu Gln Asn Thr Ala Leu
                1400                1405                1410

 gag atc ttt atg gca aac aga gtt gct gtg atg ttc aac ttc cca gac     4389
 Glu Ile Phe Met Ala Asn Arg Val Ala Val Met Phe Asn Phe Pro Asp
            1415                1420                1425

 cct gca aca gta aag aaa gtg gtt aac ttt cta cct cgt gtt ggc gtt     4437
 Pro Ala Thr Val Lys Lys Val Val Asn Phe Leu Pro Arg Val Gly Val
        1430                1435                1440

 gga aca agt ttt gga ttg cct caa acc aga cgt att tca tta gct agt     4485
 Gly Thr Ser Phe Gly Leu Pro Gln Thr Arg Arg Ile Ser Leu Ala Ser
    1445                1450                1455

 cca cgt cag ctt ttt aag gct tct aat atg acc cag cga tgg caa cac     4533
 Pro Arg Gln Leu Phe Lys Ala Ser Asn Met Thr Gln Arg Trp Gln His
1460                1465                1470                1475

 aga gag ata tct aat ttt gag tac ttg atg ttt ctc aac acg ata gca     4581
 Arg Glu Ile Ser Asn Phe Glu Tyr Leu Met Phe Leu Asn Thr Ile Ala
                1480                1485                1490

 gga cgg agt tat aat gac tta aat cag tat cca gtg ttt cct tgg gtc     4629
 Gly Arg Ser Tyr Asn Asp Leu Asn Gln Tyr Pro Val Phe Pro Trp Val
            1495                1500                1505

 atc act aat tat gaa tca gaa gaa ctg gat ctt acc ttg ccc acc aac     4677
 Ile Thr Asn Tyr Glu Ser Glu Glu Leu Asp Leu Thr Leu Pro Thr Asn
        1510                1515                1520

 ttc aga gat ttg tcc aag cca ata gga gct ctg aac cca aaa aga gca     4725
 Phe Arg Asp Leu Ser Lys Pro Ile Gly Ala Leu Asn Pro Lys Arg Ala
    1525                1530                1535

 gca ttc ttc gct gag cgt tat gaa tca tgg gaa gat gat caa gtt cca     4773
 Ala Phe Phe Ala Glu Arg Tyr Glu Ser Trp Glu Asp Asp Gln Val Pro
1540                1545                1550                1555

 aag ttt cac tat ggt act cat tac tca act gca agt ttt gtt ctt gca     4821
 Lys Phe His Tyr Gly Thr His Tyr Ser Thr Ala Ser Phe Val Leu Ala
                1560                1565                1570

 tgg ctg cta aga ata gaa ccc ttt aca act tat ttc cta aat ttg caa     4869
 Trp Leu Leu Arg Ile Glu Pro Phe Thr Thr Tyr Phe Leu Asn Leu Gln
            1575                1580                1585

 gga ggc aaa ttt gat cat gca gat cga act ttt tca tca att tcc aga     4917
 Gly Gly Lys Phe Asp His Ala Asp Arg Thr Phe Ser Ser Ile Ser Arg
        1590                1595                1600

 gct tgg cga aac agt cag cgt gat acc tct gat att aag gag ttg atc     4965
 Ala Trp Arg Asn Ser Gln Arg Asp Thr Ser Asp Ile Lys Glu Leu Ile
    1605                1610                1615

 cct gaa ttt tat tat ctc cct gag atg ttt gtc aac ttc aat aat tat     5013
 Pro Glu Phe Tyr Tyr Leu Pro Glu Met Phe Val Asn Phe Asn Asn Tyr
1620                1625                1630                1635

 aat ctt gga gtg atg gat gat ggg aca gta gtg tct gat gtc gaa ctt     5061
 Asn Leu Gly Val Met Asp Asp Gly Thr Val Val Ser Asp Val Glu Leu
                1640                1645                1650

 cct cct tgg gcc aaa acc tca gaa gaa ttt gtt cac ata aac aga ttg     5109
 Pro Pro Trp Ala Lys Thr Ser Glu Glu Phe Val His Ile Asn Arg Leu
            1655                1660                1665

 gcc ctg gag agt gaa ttt gtt tcc tgc cag ctt cac caa tgg att gat     5157
 Ala Leu Glu Ser Glu Phe Val Ser Cys Gln Leu His Gln Trp Ile Asp
        1670                1675                1680

 ctc att ttt ggc tat aaa cag caa gga cca gaa gct gtc cga gcc ctc     5205
 Leu Ile Phe Gly Tyr Lys Gln Gln Gly Pro Glu Ala Val Arg Ala Leu
    1685                1690                1695

 aat gtg ttc tat tac ttg acc tat gaa gga gct gtc aat ctg aat tca     5253
 Asn Val Phe Tyr Tyr Leu Thr Tyr Glu Gly Ala Val Asn Leu Asn Ser
1700                1705                1710                1715

 ata act gat cct gtg ttg aga gag gct gtt gaa gct caa atc cga agt     5301
 Ile Thr Asp Pro Val Leu Arg Glu Ala Val Glu Ala Gln Ile Arg Ser
                1720                1725                1730

 ttt gga cag act cct tct caa cta ctc ata gag ccc cat cct ccc aga     5349
 Phe Gly Gln Thr Pro Ser Gln Leu Leu Ile Glu Pro His Pro Pro Arg
            1735                1740                1745

 ggt tct gcc atg caa gtg agt cca ttg atg ttc aca gac aaa gcc cag     5397
 Gly Ser Ala Met Gln Val Ser Pro Leu Met Phe Thr Asp Lys Ala Gln
        1750                1755                1760

 cag gat gtt atc atg gtc ctc aag ttt ccc tcc aac tcc cct gtt act     5445
 Gln Asp Val Ile Met Val Leu Lys Phe Pro Ser Asn Ser Pro Val Thr
    1765                1770                1775

 cac gtg gca gcc aac acc cag cct ggt ttg gca act ccc gct gtg atc     5493
 His Val Ala Ala Asn Thr Gln Pro Gly Leu Ala Thr Pro Ala Val Ile
1780                1785                1790                1795

 aca gtc act gct aac agg tta ttt gcg gtg aac aaa tgg cac aac ctt     5541
 Thr Val Thr Ala Asn Arg Leu Phe Ala Val Asn Lys Trp His Asn Leu
                1800                1805                1810

 cct gct cat caa ggt gct gta caa gac cag cca tac cag ctg cca gtg     5589
 Pro Ala His Gln Gly Ala Val Gln Asp Gln Pro Tyr Gln Leu Pro Val
            1815                1820                1825

 gaa atc gat cct ctc ata gcc agc aat aca gga atg cac agg agg caa     5637
 Glu Ile Asp Pro Leu Ile Ala Ser Asn Thr Gly Met His Arg Arg Gln
        1830                1835                1840

 atc act gac ctt tta gac caa agt att caa gtg cat tcc cag tgc ttt     5685
 Ile Thr Asp Leu Leu Asp Gln Ser Ile Gln Val His Ser Gln Cys Phe
    1845                1850                1855

 gtc atc act tca gac aac cgc tat att ctc gtc tgt ggc ttc tgg gat     5733
 Val Ile Thr Ser Asp Asn Arg Tyr Ile Leu Val Cys Gly Phe Trp Asp
1860                1865                1870                1875

 aaa agt ttc aga gtc tat tct aca gac aca gga aga ttg atc caa gtg     5781
 Lys Ser Phe Arg Val Tyr Ser Thr Asp Thr Gly Arg Leu Ile Gln Val
                1880                1885                1890

 gtg ttt ggc cat tgg gat gtc gtc act tgc ctt gct cgt tct gag tca     5829
 Val Phe Gly His Trp Asp Val Val Thr Cys Leu Ala Arg Ser Glu Ser
            1895                1900                1905

 tat att ggg gga aat tgc tac att ctc tca ggg tca cgt gat gca act     5877
 Tyr Ile Gly Gly Asn Cys Tyr Ile Leu Ser Gly Ser Arg Asp Ala Thr
        1910                1915                1920

 ctt ttg ctg tgg tat tgg aat gga aaa tgc agt ggg att gga gat aac     5925
 Leu Leu Leu Trp Tyr Trp Asn Gly Lys Cys Ser Gly Ile Gly Asp Asn
    1925                1930                1935

 cca ggc agt gag act gct gct cct cgg gcc att ttg acc ggc cat gac     5973
 Pro Gly Ser Glu Thr Ala Ala Pro Arg Ala Ile Leu Thr Gly His Asp
1940                1945                1950                1955

 tat gag gtc aca tgt gct gcg gtg tgt gcg gag cta ggc ctg gtg ttg     6021
 Tyr Glu Val Thr Cys Ala Ala Val Cys Ala Glu Leu Gly Leu Val Leu
                1960                1965                1970

 agt ggt tca caa gaa gga cca tgt ctc ata cat tcc atg aat gga gac     6069
 Ser Gly Ser Gln Glu Gly Pro Cys Leu Ile His Ser Met Asn Gly Asp
            1975                1980                1985

 ttg ttg agg acc ttg gag ggt cct gaa aac tgc ctg aaa cca aaa ctc     6117
 Leu Leu Arg Thr Leu Glu Gly Pro Glu Asn Cys Leu Lys Pro Lys Leu
        1990                1995                2000

 att cag gct tca aga gag ggt cat tgt gtc ata ttc tat gaa aac ggc     6165
 Ile Gln Ala Ser Arg Glu Gly His Cys Val Ile Phe Tyr Glu Asn Gly
    2005                2010                2015

 ctc ttc tgt aca ttc agt gtg aat gga aaa ctc cag gcc acg atg gaa     6213
 Leu Phe Cys Thr Phe Ser Val Asn Gly Lys Leu Gln Ala Thr Met Glu
2020                2025                2030                2035

 aca gat gat aac ata aga gcc atc cag ctg agc cga gat ggg cag tac     6261
 Thr Asp Asp Asn Ile Arg Ala Ile Gln Leu Ser Arg Asp Gly Gln Tyr
                2040                2045                2050

 ctg ctc aca gga gga gac aga gga gtg gtc gtg gtc cgg cag gtg tcg     6309
 Leu Leu Thr Gly Gly Asp Arg Gly Val Val Val Val Arg Gln Val Ser
            2055                2060                2065

 gac ctc aag cag ctc ttt gcc tat cca gga tgt gac gct gga atc cgg     6357
 Asp Leu Lys Gln Leu Phe Ala Tyr Pro Gly Cys Asp Ala Gly Ile Arg
        2070                2075                2080

 gcc atg gcg ctg tct tac gac cag agg tgc atc att tct ggc atg gct     6405
 Ala Met Ala Leu Ser Tyr Asp Gln Arg Cys Ile Ile Ser Gly Met Ala
    2085                2090                2095

 tca gga agc att gtg cta ttt tac aac gac ttt aac cgg tgg cat cat     6453
 Ser Gly Ser Ile Val Leu Phe Tyr Asn Asp Phe Asn Arg Trp His His
2100                2105                2110                2115

 gaa tac caa acc cgc tac tga tg gtgacagctg tacatcaact ctgcccctag     6506
 Glu Tyr Gln Thr Arg Tyr 
                2120

 gatgagcaga agtacctgga gcatcattct cttctaccac atctgaatgt aacttaaatt   6566

 tgctcaaaga agcaaaatat tttttaaagt tattaataat tgctattttt gtagtctttg   6626

 cttgactttt ttggggggga ttagcaaagc agaaaactgg ctgctgggtt ctgtagtttt   6686

 aaaaaatcta tatttttagt cataatgaga agtctatttt caccaattat ggaaacatac   6746

 agtggagcaa gtaaaccact tattccagct ataatattat gaagaacatt tcccatgcat   6806

 ctacaagctt gagaaatagg attttcacag tggggaagtg ggttacaata ttggaatagg   6866

 aaaatttgat gctgtaattt gggtcctgta tttttccaaa caactgtgct tcttcagcac   6926

 taatatttct gggatttaaa tagtaatgtt taaattatgg taaatgtaat ttaaaacatc   6986

 tcaattaagt ctgtctatca atattgttct tcaagcatgt tttagaccta gaaaagtatg   7046

 gtttggggga ggctatttta ttgtgtggtt agcacaagga atctaattta tagcaagtgt   7106

 gaaatagtta ccattttttc ctgatctgtc atcttcatag cacaacaaaa cgaaatgatg   7166

 gaaatgctct tgagctcaca acatttgttt ttcttttaaa gtaaatgcaa gtaccaaagc   7226

 tcactactgc ggtttgcctg tgcctggaca atgaggcgga gccactgttg ttggggcacc   7286

 cccttccctc cccgggtttg caaatagagg ctaccgggtg ctgtattcag caacacctgt   7346

 tttactattt gttattaaac tatcatctcc accttccttt tgattagcaa tttgtactaa   7406

 gaaacgaaac aatgttattt ggtggtgtat aattctactt ttctagtaga ttactgtgtg   7466

 gaattctgtg aaaaatattt gagaaaaggc ctgtattgca taaataaatt ctttgtatgt   7526

 tgtgaaaaaa aaaaaaa                                                  7543




      <210> 162
      <211> 1502
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (267)..(1448)

      <400> 162
 acgccagctt ggacgagggg gtcctcgcca aggttcggaa gaggaccttg aaaatggctt     60

 ctgggcatgc gccacagcgg ccgttacgag acgcaaaacc gacgccttgg aactgagagc    120

 ctagagggac ggagctcggc gcaccatgag gctcccgggg cccaaggccg accgtgagag    180

 cgcacgagct gagtcagtgc tgattctctc aaatagagct tgaaggataa atcttcattt    240

 ttgtttcaac aaaacttcga aacaaa atg gaa gaa aat aat cta cag tgc agt     293
                              Met Glu Glu Asn Asn Leu Gln Cys Ser
                                1               5

 agt gtg gtt gac ggt aat ttt gaa gaa gtt ccc agg gag acg gca att      341
 Ser Val Val Asp Gly Asn Phe Glu Glu Val Pro Arg Glu Thr Ala Ile
  10                  15                  20                  25

 cag ttt aaa cct cca cta tac aga cag cgg tac cag ttc gtt aaa aat      389
 Gln Phe Lys Pro Pro Leu Tyr Arg Gln Arg Tyr Gln Phe Val Lys Asn
                  30                  35                  40

 tta gtg gat caa cat gag cct aag aag gtt gca gac ctg gga tgt ggt      437
 Leu Val Asp Gln His Glu Pro Lys Lys Val Ala Asp Leu Gly Cys Gly
              45                  50                  55

 gat act tca ctc tta agg ctg cta aaa gtc aat cca tgc att gaa ttg      485
 Asp Thr Ser Leu Leu Arg Leu Leu Lys Val Asn Pro Cys Ile Glu Leu
          60                  65                  70

 ctt gtt gga gta gat att aat gag gat aaa tta cga tgg aga ggg gat      533
 Leu Val Gly Val Asp Ile Asn Glu Asp Lys Leu Arg Trp Arg Gly Asp
      75                  80                  85

 tcg tta gct cct ttc ctg ggg gat ttt ctg aaa cct cgg gat ctg aat      581
 Ser Leu Ala Pro Phe Leu Gly Asp Phe Leu Lys Pro Arg Asp Leu Asn
  90                  95                 100                 105

 ttg acc atc aca ttg tat cat ggc tcc gtt gtg gag aga gac tct cgt      629
 Leu Thr Ile Thr Leu Tyr His Gly Ser Val Val Glu Arg Asp Ser Arg
                 110                 115                 120

 ttg ctt gga ttt gac ttg ata acg tgt att gaa tta ata gaa cat ttg      677
 Leu Leu Gly Phe Asp Leu Ile Thr Cys Ile Glu Leu Ile Glu His Leu
             125                 130                 135

 gat tca ggt gat ctg gcc aga ttt cct gaa gtg gta ttt ggg tac ctg      725
 Asp Ser Gly Asp Leu Ala Arg Phe Pro Glu Val Val Phe Gly Tyr Leu
         140                 145                 150

 tct cca tcc atg att gtc atc agc aca cca aac tct gaa ttc aat ccc      773
 Ser Pro Ser Met Ile Val Ile Ser Thr Pro Asn Ser Glu Phe Asn Pro
     155                 160                 165

 ctg ttt cca tca gtg acc tta aga gat tca gat cat aaa ttt gag tgg      821
 Leu Phe Pro Ser Val Thr Leu Arg Asp Ser Asp His Lys Phe Glu Trp
 170                 175                 180                 185

 acc aga atg gag ttt cag acc tgg gct tta tat gtg gca aat cgc tat      869
 Thr Arg Met Glu Phe Gln Thr Trp Ala Leu Tyr Val Ala Asn Arg Tyr
                 190                 195                 200

 gat tac tct gtg gag ttt act ggt gtc ggg gaa cca cca gct gga gct      917
 Asp Tyr Ser Val Glu Phe Thr Gly Val Gly Glu Pro Pro Ala Gly Ala
             205                 210                 215

 gag aat gtt gga tac tgt acc cag ata gga atc ttc cgg aaa aat gga      965
 Glu Asn Val Gly Tyr Cys Thr Gln Ile Gly Ile Phe Arg Lys Asn Gly
         220                 225                 230

 gga aag gca aca gaa tca tgt ctt tca gag cag cat gat cag cat gtt     1013
 Gly Lys Ala Thr Glu Ser Cys Leu Ser Glu Gln His Asp Gln His Val
     235                 240                 245

 tat aaa gct gtt ttt acc acc tca tac cca agc tta cag cag gaa agg     1061
 Tyr Lys Ala Val Phe Thr Thr Ser Tyr Pro Ser Leu Gln Gln Glu Arg
 250                 255                 260                 265

 ttc ttt aaa ctt gtg ttg gtt aat gag gtg tcc caa caa gtg gaa agc     1109
 Phe Phe Lys Leu Val Leu Val Asn Glu Val Ser Gln Gln Val Glu Ser
                 270                 275                 280

 tta aga gtg agc cac ctg cca agg cgg aaa gaa cag gct ggg gaa cgg     1157
 Leu Arg Val Ser His Leu Pro Arg Arg Lys Glu Gln Ala Gly Glu Arg
             285                 290                 295

 ggt gat aag ccc aaa gac att ggt ggc tca aag gcc cct gtc cca tgc     1205
 Gly Asp Lys Pro Lys Asp Ile Gly Gly Ser Lys Ala Pro Val Pro Cys
         300                 305                 310

 ttt gga cca gtc ttc aca gag gtt gag aag gcc aag ata gag aac tct     1253
 Phe Gly Pro Val Phe Thr Glu Val Glu Lys Ala Lys Ile Glu Asn Ser
     315                 320                 325

 ccc aca ccc ttc tgt gtt gga gat aaa ttt ttc gta cct ctg cag aga     1301
 Pro Thr Pro Phe Cys Val Gly Asp Lys Phe Phe Val Pro Leu Gln Arg
 330                 335                 340                 345

 ctc ctt gcg tat ccc aag ttg aac cgc tta tgt gct aat gaa gag atg     1349
 Leu Leu Ala Tyr Pro Lys Leu Asn Arg Leu Cys Ala Asn Glu Glu Met
                 350                 355                 360

 atg aga tca gtc att gct gac tca att cct ctg agc agt gat ggt tct     1397
 Met Arg Ser Val Ile Ala Asp Ser Ile Pro Leu Ser Ser Asp Gly Ser
             365                 370                 375

 gca gtg gtg gct gac ctg cgt aat tat ttt gat gaa cag ttt gag ttt     1445
 Ala Val Val Ala Asp Leu Arg Asn Tyr Phe Asp Glu Gln Phe Glu Phe
         380                 385                 390

 tga acca tgtttatttc ctgaaatttc agggtctcag cgatagttgt gctcacttag     1502
 






      <210> 163
      <211> 2886
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (403)..(1677)

      <220>
      <221> misc_feature
      <222> (1)...(2886)
      <223> n = a,t,c or g

      <400> 163
 ctttcataca tttttgtaag ttatgtttcc atgtctcgtg tgtgatgttg tgtactgttg     60

 acatgaaata ctcctttttt ggtaaagatg gattggctta acagattaga gctacagaaa    120

 gtatgactta gcacgctggt aaggccacaa aaacccaagc aagttccccc agtttcgtat    180

 cctgtaaata gagataagtt agtttttctg tttcagagag tggttatgga aaactactag    240

 gctttaaaat gattgttaat ctcagtgtgg ggacatttgg tttggggaca tcagttcagg    300

 agtaaatgta tctgatcctg ctttgaataa atgcaacttg aaagccttgg aattttacca    360

 gatcgaatct gggccaaata gaaagcattt taagaaagaa ag   atg gat caa cct     414
                                                  Met Asp Gln Pro
                                                    1

 agt gga aga agt ttc atg caa gta tta tgt gaa aaa tat agt cct gaa      462
 Ser Gly Arg Ser Phe Met Gln Val Leu Cys Glu Lys Tyr Ser Pro Glu
   5                  10                  15                  20

 aat ttt cct tat cgc cgt ggc ccg ggg atg gga gtc cat gtc cca gcc      510
 Asn Phe Pro Tyr Arg Arg Gly Pro Gly Met Gly Val His Val Pro Ala
                  25                  30                  35

 aca cct cag ggc tct cct atg aaa gat cgc ctc aac ctc cca agt gta      558
 Thr Pro Gln Gly Ser Pro Met Lys Asp Arg Leu Asn Leu Pro Ser Val
              40                  45                  50

 cta gtg ttg aac agc tgt gga ata acc tgt gca gga gat gaa aaa gaa      606
 Leu Val Leu Asn Ser Cys Gly Ile Thr Cys Ala Gly Asp Glu Lys Glu
          55                  60                  65

 att gct gct ttc tgc gct cat gtg tcg gaa cta gat ctt tct gac aac      654
 Ile Ala Ala Phe Cys Ala His Val Ser Glu Leu Asp Leu Ser Asp Asn
      70                  75                  80

 aaa ctc gaa gac tgg cat gag gtc agt aaa att gtg tca aat gtt cct      702
 Lys Leu Glu Asp Trp His Glu Val Ser Lys Ile Val Ser Asn Val Pro
  85                  90                  95                 100

 cag ttg gag ttt cta aac ctg agt tcc aac cct ctg aat ttg tcg gtt      750
 Gln Leu Glu Phe Leu Asn Leu Ser Ser Asn Pro Leu Asn Leu Ser Val
                 105                 110                 115

 tta gaa aga aca tgt gct ggg tcc ttc tct ggg gtt cgc aaa ctt gtc      798
 Leu Glu Arg Thr Cys Ala Gly Ser Phe Ser Gly Val Arg Lys Leu Val
             120                 125                 130

 ctc aac aac agc aaa gct tct tgg gag acg gtc cac atg ata cta cag      846
 Leu Asn Asn Ser Lys Ala Ser Trp Glu Thr Val His Met Ile Leu Gln
         135                 140                 145

 gag tta cca gat ttg gag gag ctc ttc ctg tgc ctt aat gac tat gaa      894
 Glu Leu Pro Asp Leu Glu Glu Leu Phe Leu Cys Leu Asn Asp Tyr Glu
     150                 155                 160

 aca gtg tct tgt cct tct att tgc tgt cat tct ctt aag cta cta cat      942
 Thr Val Ser Cys Pro Ser Ile Cys Cys His Ser Leu Lys Leu Leu His
 165                 170                 175                 180

 ata aca gac aat aac ctc caa gac tgg act gaa ata cga aag tta gga      990
 Ile Thr Asp Asn Asn Leu Gln Asp Trp Thr Glu Ile Arg Lys Leu Gly
                 185                 190                 195

 gtt atg ttt cct tca ctg gat acc ctc gtc ctg gcc aac aat cat ttg     1038
 Val Met Phe Pro Ser Leu Asp Thr Leu Val Leu Ala Asn Asn His Leu
             200                 205                 210

 aat gct att gag gag cct gat gat tca ttg gcc agg ttg ttt cct aat     1086
 Asn Ala Ile Glu Glu Pro Asp Asp Ser Leu Ala Arg Leu Phe Pro Asn
         215                 220                 225

 ctt cga tcc atc agc ctc cac aag tca ggt ttg cag tcc tgg gaa gac     1134
 Leu Arg Ser Ile Ser Leu His Lys Ser Gly Leu Gln Ser Trp Glu Asp
     230                 235                 240

 att gat aaa cta aat tca ttt ccc aaa ctg gaa gaa gtg aga ttg tta     1182
 Ile Asp Lys Leu Asn Ser Phe Pro Lys Leu Glu Glu Val Arg Leu Leu
 245                 250                 255                 260

 gga att cct ctt ctg cag cca tat acc acc gag gag cga agg aaa ttg     1230
 Gly Ile Pro Leu Leu Gln Pro Tyr Thr Thr Glu Glu Arg Arg Lys Leu
                 265                 270                 275

 gta ata gcc aga ttg cca tca gtt tcc aaa ctt aat ggc agc gtt gtt     1278
 Val Ile Ala Arg Leu Pro Ser Val Ser Lys Leu Asn Gly Ser Val Val
             280                 285                 290

 act gat ggt gaa cga gaa gat tct gag aga ttt ttt att cgt tac tat     1326
 Thr Asp Gly Glu Arg Glu Asp Ser Glu Arg Phe Phe Ile Arg Tyr Tyr
         295                 300                 305

 gtg gat gtt cca cag gaa gaa gtg cca ttc agg tat cat gaa ctg atc     1374
 Val Asp Val Pro Gln Glu Glu Val Pro Phe Arg Tyr His Glu Leu Ile
     310                 315                 320

 act aaa tat ggg aag ttg gag cct ttg gca gaa gtg gac cta aga ccc     1422
 Thr Lys Tyr Gly Lys Leu Glu Pro Leu Ala Glu Val Asp Leu Arg Pro
 325                 330                 335                 340

 cag agc agt gca aaa gta gaa gtc cac ttt aac gat cag gtg gaa gaa     1470
 Gln Ser Ser Ala Lys Val Glu Val His Phe Asn Asp Gln Val Glu Glu
                 345                 350                 355

 atg agc att cgt ctg gac caa aca gtg gca gaa cta aag aaa cag tta     1518
 Met Ser Ile Arg Leu Asp Gln Thr Val Ala Glu Leu Lys Lys Gln Leu
             360                 365                 370

 aaa act cta gta caa tta ccc aca agc aac atg ctt ctc tac tat ttt     1566
 Lys Thr Leu Val Gln Leu Pro Thr Ser Asn Met Leu Leu Tyr Tyr Phe
         375                 380                 385

 gac cat gaa gca ccc ttt ggc cca gag gaa atg aag tac agc tct cgg     1614
 Asp His Glu Ala Pro Phe Gly Pro Glu Glu Met Lys Tyr Ser Ser Arg
     390                 395                 400

 gca ttg cat tcc ttt ggc att agg gat gga gat aaa att tac gtg gaa     1662
 Ala Leu His Ser Phe Gly Ile Arg Asp Gly Asp Lys Ile Tyr Val Glu
 405                 410                 415                 420

 tcc aaa aca aaa taa cctctaccag ccttgtgaaa aacatacaca taaggacttg     1717
 Ser Lys Thr Lys 


 ttgcagggca tttgttttta atgtggtttt ctttaggagg gagaggttgt ttttgttttg   1777

 ttttgttctg tttaggtttg ggaaggattt tgtatatttt tccccctgga gtgagtaggg   1837

 gccatttttg ggtgttttct accacagatt gatttggctc agccagcgga attggccaca   1897

 tttccagtgt atgtgccctc tctaaggaaa gatgacaaag aaatcaccga cttcttactg   1957

 tgttcactgg gatttgcctg ccacttggtt atcattactg ttgggtgaac ctgtgaagat   2017

 aacatgaaca ctgtagcccc ttagaagggt ctcatagaga atttaaacag ggtgacaagg   2077

 aatcttcaca ggaagggcca gaacttctct ctcccagttc ttccttccgc taccctccct   2137

 ccttggcttt tttggttcag ttccattttt ttttcatttt gacatgtggt ttacctaata   2197

 gttttgttct gttcataatt cttatttctc aacctgggtg atttttttgt tctcatttct   2257

 cccttttgaa ataattgaaa gtgttttaag catttttaac ctgattctaa tctcaggtac   2317

 gcagtaagaa gctataactc tgttagaacc tcgaagagta gatgtagaat gaaaactcca   2377

 ggaaaacttg cagttattct ggaagcaccg gcagaacagt ctgatctctt tgtatgttac   2437

 taactcactt ttaatgtccc tgtacattat gtcagccatt actttcataa catgaaatat   2497

 gtcagattcc agagttcttt tatttttgct tattgaatgt atttcctcat atctttcttt   2557

 ttcattactt taaactattg ggaattgagg cctgacttca taaataattc aatagagtcc   2617

 tggatacgtg caccaggaga gttgagaatt agctcataaa ctatctgtgg tgtgtgtggg   2677

 gaatgaagtt gggggatgtg ggggaagagc ttatgacttt cccacctgtg tcatccattg   2737

 gaagcccttg ctcttgcact ttgcattaaa agtgggaaac attaatcaaa gggagatttt   2797

 attcccaggt tttccctggg actttgtgat atcataattg aacagttctt ttgttttnca   2857

 tttcaattta gttgcctcat agaagtata                                     2886




      <210> 164
      <211> 4202
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (238)..(3441)

      <400> 164
 aagaaaaggc tacatctaaa cagcatccta tgggaccagt ggcttcaata tcctgaacaa     60

 ggggactcca acttctcttg gactcttaag acccatgggt tctggcagtt ggccttttta    120

 ggcaactcct ataacagcag catacccagg tgtctgtctg taaccctcac agaaaagcta    180

 ctgctgacct ttgaccctat ccttgttgag aaggttgcta ttttgttata ccatatc       237                                                                 
 atg caa gat aac cca cag tta ccc cgc ctt tat ctg agt gga gta ttt      285
 Met Gln Asp Asn Pro Gln Leu Pro Arg Leu Tyr Leu Ser Gly Val Phe
   1               5                  10                  15

 ttc ttt atc atg atg tac aca ggt tcc aat gtg ctt cct gtt gct cgg      333
 Phe Phe Ile Met Met Tyr Thr Gly Ser Asn Val Leu Pro Val Ala Arg
              20                  25                  30

 cgc ctg atg ata gag aag att gct gcc cat ctc gcg gat ttc aca cct      381
 Arg Leu Met Ile Glu Lys Ile Ala Ala His Leu Ala Asp Phe Thr Pro
          35                  40                  45

 cgt ctt cag agt aac aca aga gca ctt tat cag tat tgc ccc att cct      429
 Arg Leu Gln Ser Asn Thr Arg Ala Leu Tyr Gln Tyr Cys Pro Ile Pro
      50                  55                  60

 ata atc aac tat cca caa ctc gaa aat gaa cta ttt tgt aat att tat      477
 Ile Ile Asn Tyr Pro Gln Leu Glu Asn Glu Leu Phe Cys Asn Ile Tyr
  65                  70                  75                  80

 tac ctc aaa caa ctg tgt gat aca ctc cgg ttt cca gat tgg cca att      525
 Tyr Leu Lys Gln Leu Cys Asp Thr Leu Arg Phe Pro Asp Trp Pro Ile
                  85                  90                  95

 aaa gac ccg gtt aag ctt cta aaa gat acc ctt gat gcc tgg aag aaa      573
 Lys Asp Pro Val Lys Leu Leu Lys Asp Thr Leu Asp Ala Trp Lys Lys
             100                 105                 110

 gaa gta gaa aag aag cca cct atg atg tca ata gat gat gct tat gaa      621
 Glu Val Glu Lys Lys Pro Pro Met Met Ser Ile Asp Asp Ala Tyr Glu
         115                 120                 125

 gtg ctt aat ctg cct caa gga cag gga ccg cat gat gag agc aag att      669
 Val Leu Asn Leu Pro Gln Gly Gln Gly Pro His Asp Glu Ser Lys Ile
     130                 135                 140

 agg aaa gct tac ttc aga ctt gca caa aag tac cac cct gat aag aat      717
 Arg Lys Ala Tyr Phe Arg Leu Ala Gln Lys Tyr His Pro Asp Lys Asn
 145                 150                 155                 160

 cca gaa ggg agg gac atg ttt gaa aaa gta aat aaa gca tat gaa ttt      765
 Pro Glu Gly Arg Asp Met Phe Glu Lys Val Asn Lys Ala Tyr Glu Phe
                 165                 170                 175

 tta tgt acc aaa tca gca aaa ata gtg gat ggg cca gat cca gag aat      813
 Leu Cys Thr Lys Ser Ala Lys Ile Val Asp Gly Pro Asp Pro Glu Asn
             180                 185                 190

 ata att tta att cta aaa aca cag agc atc ctc ttc aac cgt cat aaa      861
 Ile Ile Leu Ile Leu Lys Thr Gln Ser Ile Leu Phe Asn Arg His Lys
         195                 200                 205

 gaa gat tta cag cct tat aaa tat gca gga tac ccc atg ctt att cgg      909
 Glu Asp Leu Gln Pro Tyr Lys Tyr Ala Gly Tyr Pro Met Leu Ile Arg
     210                 215                 220

 act ata aca atg gaa act tca gat gac ctc ctt ttc tca aaa gaa tca      957
 Thr Ile Thr Met Glu Thr Ser Asp Asp Leu Leu Phe Ser Lys Glu Ser
 225                 230                 235                 240

 cca ttg ttg cct gcg gct aca gag cta gct ttc cat act gtc aac tgt     1005
 Pro Leu Leu Pro Ala Ala Thr Glu Leu Ala Phe His Thr Val Asn Cys
                 245                 250                 255

 tca gcc ctc aat gct gaa gag ctc aga aga gag aat gga cta gag gtg     1053
 Ser Ala Leu Asn Ala Glu Glu Leu Arg Arg Glu Asn Gly Leu Glu Val
             260                 265                 270

 tta caa gag gca ttt agt cgc tgt gtg gct gtc ttg act cgt tct agt     1101
 Leu Gln Glu Ala Phe Ser Arg Cys Val Ala Val Leu Thr Arg Ser Ser
         275                 280                 285

 aaa cca agt gac atg tca gta cag gtg tgt gga tac ata agt aaa tgc     1149
 Lys Pro Ser Asp Met Ser Val Gln Val Cys Gly Tyr Ile Ser Lys Cys
     290                 295                 300

 tac agt gtg gct gct cag ttt gag gaa tgc cga gag aag atc acg gaa     1197
 Tyr Ser Val Ala Ala Gln Phe Glu Glu Cys Arg Glu Lys Ile Thr Glu
 305                 310                 315                 320

 atg cct agc atc atc aag gat ctc tgt cgg gta cta tat ttt ggc aag     1245
 Met Pro Ser Ile Ile Lys Asp Leu Cys Arg Val Leu Tyr Phe Gly Lys
                 325                 330                 335

 agt att ccc cgc gta gct gct ctt ggg gta gaa tgt gtc agt tct ttt     1293
 Ser Ile Pro Arg Val Ala Ala Leu Gly Val Glu Cys Val Ser Ser Phe
             340                 345                 350

 gct gtg gat ttc tgg cta cag aca cac cta ttt cag gct gga att ttg     1341
 Ala Val Asp Phe Trp Leu Gln Thr His Leu Phe Gln Ala Gly Ile Leu
         355                 360                 365

 tgg tat ctc ctt ggt ttt ctg ttt aat tat gac tac aca cta gaa gag     1389
 Trp Tyr Leu Leu Gly Phe Leu Phe Asn Tyr Asp Tyr Thr Leu Glu Glu
     370                 375                 380

 agt ggc att cag aaa agt gaa gaa aca aac cag cag gag gta gca aac     1437
 Ser Gly Ile Gln Lys Ser Glu Glu Thr Asn Gln Gln Glu Val Ala Asn
 385                 390                 395                 400

 agc ctt gcc aaa ctg agt gtc cat gct ctg agt cgc ctt gga ggg tat     1485
 Ser Leu Ala Lys Leu Ser Val His Ala Leu Ser Arg Leu Gly Gly Tyr
                 405                 410                 415

 ttg gct gaa gaa caa gca act cca gaa aat cca acc ata agg aaa agc     1533
 Leu Ala Glu Glu Gln Ala Thr Pro Glu Asn Pro Thr Ile Arg Lys Ser
             420                 425                 430

 tta gct ggc atg ctg aca ccc tat gtt gct aga aaa ctt gct gtg gct     1581
 Leu Ala Gly Met Leu Thr Pro Tyr Val Ala Arg Lys Leu Ala Val Ala
         435                 440                 445

 agt gtg act gag att ttg aag atg ctt aac agc aac aca gaa agt cca     1629
 Ser Val Thr Glu Ile Leu Lys Met Leu Asn Ser Asn Thr Glu Ser Pro
     450                 455                 460

 tat ttg ata tgg aac aat tct aca aga gca gaa tta ctt gaa ttt ctt     1677
 Tyr Leu Ile Trp Asn Asn Ser Thr Arg Ala Glu Leu Leu Glu Phe Leu
 465                 470                 475                 480

 gaa tcc caa caa gaa aac atg att aaa aaa ggt gat tgt gac aaa act     1725
 Glu Ser Gln Gln Glu Asn Met Ile Lys Lys Gly Asp Cys Asp Lys Thr
                 485                 490                 495

 tat gga tca gaa ttt gtc tac agt gat cat gcc aaa gaa ctt att gta     1773
 Tyr Gly Ser Glu Phe Val Tyr Ser Asp His Ala Lys Glu Leu Ile Val
             500                 505                 510

 ggg gag att ttt gtt agg gtg tat aat gaa gtt cct act ttc caa ctg     1821
 Gly Glu Ile Phe Val Arg Val Tyr Asn Glu Val Pro Thr Phe Gln Leu
         515                 520                 525

 gag gtt cca aaa gca ttt gct gca agt ctc ttg gat tat ata ggc tcg     1869
 Glu Val Pro Lys Ala Phe Ala Ala Ser Leu Leu Asp Tyr Ile Gly Ser
     530                 535                 540

 cag gcc caa tac ttg cac aca ttc atg gcc atc aca cac gcg gca aaa     1917
 Gln Ala Gln Tyr Leu His Thr Phe Met Ala Ile Thr His Ala Ala Lys
 545                 550                 555                 560

 gtg gag tca gag caa cat gga gat cgc tta ccg aga gta gaa atg gct     1965
 Val Glu Ser Glu Gln His Gly Asp Arg Leu Pro Arg Val Glu Met Ala
                 565                 570                 575

 ttg gag gct ctg aga aat gtc ata aaa tac aat cca ggt tct gag agt     2013
 Leu Glu Ala Leu Arg Asn Val Ile Lys Tyr Asn Pro Gly Ser Glu Ser
             580                 585                 590

 gaa tgc att ggg cac ttt aag ttg ata ttt tct ctt ctc cga gtt cat     2061
 Glu Cys Ile Gly His Phe Lys Leu Ile Phe Ser Leu Leu Arg Val His
         595                 600                 605

 gga gct ggt caa gtg cag cag ttg gct tta gag gtt gtg aat ata gtg     2109
 Gly Ala Gly Gln Val Gln Gln Leu Ala Leu Glu Val Val Asn Ile Val
     610                 615                 620

 aca tct aac caa gac tgt gtc aac aat att gct gaa tca atg gtt ttg     2157
 Thr Ser Asn Gln Asp Cys Val Asn Asn Ile Ala Glu Ser Met Val Leu
 625                 630                 635                 640

 tcc agt tta ttg gct ctt cta cat tca ttg cca tca agt cgt cag ctt     2205
 Ser Ser Leu Leu Ala Leu Leu His Ser Leu Pro Ser Ser Arg Gln Leu
                 645                 650                 655

 gtt ctg gaa act ctt tat gct ttg aca tcg agt aca aaa ata atc aaa     2253
 Val Leu Glu Thr Leu Tyr Ala Leu Thr Ser Ser Thr Lys Ile Ile Lys
             660                 665                 670

 gaa gca atg gca aag ggt gct ttg atc tat tta ctg gat atg ttc tgc     2301
 Glu Ala Met Ala Lys Gly Ala Leu Ile Tyr Leu Leu Asp Met Phe Cys
         675                 680                 685

 aat tca aca cat cca cag gtt cga gcc caa aca gca gaa ctt ttt gcc     2349
 Asn Ser Thr His Pro Gln Val Arg Ala Gln Thr Ala Glu Leu Phe Ala
     690                 695                 700

 aaa atg aca gca gat aaa ctg ata ggt cca aag gtt cga att acg tta     2397
 Lys Met Thr Ala Asp Lys Leu Ile Gly Pro Lys Val Arg Ile Thr Leu
 705                 710                 715                 720

 atg aaa ttt cta cca agc gtt ttc atg gat gct atg aga gac aat cct     2445
 Met Lys Phe Leu Pro Ser Val Phe Met Asp Ala Met Arg Asp Asn Pro
                 725                 730                 735

 gaa gct gct gta cat att ttt gaa gga act cat gaa aat cct gag tta     2493
 Glu Ala Ala Val His Ile Phe Glu Gly Thr His Glu Asn Pro Glu Leu
             740                 745                 750

 att tgg aat gat aat tcc aga gat aaa gtg tcc aca aca gtt agg gaa     2541
 Ile Trp Asn Asp Asn Ser Arg Asp Lys Val Ser Thr Thr Val Arg Glu
         755                 760                 765

 atg atg cta gag cac ttt aaa aat cag cag gac aac cct gag gca aac     2589
 Met Met Leu Glu His Phe Lys Asn Gln Gln Asp Asn Pro Glu Ala Asn
     770                 775                 780

 tgg aag ttg cct gaa gat ttt gct gtg gtg ttt gga gaa gca gag ggt     2637
 Trp Lys Leu Pro Glu Asp Phe Ala Val Val Phe Gly Glu Ala Glu Gly
 785                 790                 795                 800

 gaa ctt gct gtt gga gga gtc ttc ttg agg atc ttt att gca caa cca     2685
 Glu Leu Ala Val Gly Gly Val Phe Leu Arg Ile Phe Ile Ala Gln Pro
                 805                 810                 815

 gcc tgg gtt cta aga aag cct aga gaa ttt ctt att gcc ctg tta gaa     2733
 Ala Trp Val Leu Arg Lys Pro Arg Glu Phe Leu Ile Ala Leu Leu Glu
             820                 825                 830

 aaa tta act gag ctc cta gag aag aac aat cct cat gga gaa act ctg     2781
 Lys Leu Thr Glu Leu Leu Glu Lys Asn Asn Pro His Gly Glu Thr Leu
         835                 840                 845

 gaa acc ttg aca atg gca aca gtg tgt ctc ttc agc gca caa cct cag     2829
 Glu Thr Leu Thr Met Ala Thr Val Cys Leu Phe Ser Ala Gln Pro Gln
     850                 855                 860

 ctg gca gat cag gtc ccg cca ttg ggc cat ctt ccc aaa gtt atc cag     2877
 Leu Ala Asp Gln Val Pro Pro Leu Gly His Leu Pro Lys Val Ile Gln
 865                 870                 875                 880

 gca atg aat cat agg aac aat gcc att cct aag agt gcc att cgg gtt     2925
 Ala Met Asn His Arg Asn Asn Ala Ile Pro Lys Ser Ala Ile Arg Val
                 885                 890                 895

 atc cat gcc ttg tct gaa aat gag ctg tgt gtt cga gcc atg gca tct     2973
 Ile His Ala Leu Ser Glu Asn Glu Leu Cys Val Arg Ala Met Ala Ser
             900                 905                 910

 tta gag acc att ggc cca ctg atg aat gga atg aaa aag cga gca gat     3021
 Leu Glu Thr Ile Gly Pro Leu Met Asn Gly Met Lys Lys Arg Ala Asp
         915                 920                 925

 act gtt ggt cta gcc tgt gaa gca att aat cga atg ttt cag aag gag     3069
 Thr Val Gly Leu Ala Cys Glu Ala Ile Asn Arg Met Phe Gln Lys Glu
     930                 935                 940

 cag agt gaa tta gta gca caa gcc ctg aaa gca gat ttg gtt cca tac     3117
 Gln Ser Glu Leu Val Ala Gln Ala Leu Lys Ala Asp Leu Val Pro Tyr
 945                 950                 955                 960

 ctc tta aaa tta ctc gaa ggc att ggc ctt gaa aac ctg gac agc cca     3165
 Leu Leu Lys Leu Leu Glu Gly Ile Gly Leu Glu Asn Leu Asp Ser Pro
                 965                 970                 975

 gca gcc act aag gct cag att gtt aaa gct ctc aag gca atg act cga     3213
 Ala Ala Thr Lys Ala Gln Ile Val Lys Ala Leu Lys Ala Met Thr Arg
             980                 985                 990

 agt ttg cag tat gga gaa cag gtg aat gaa atc ctg tgc cgt tct tca     3261
 Ser Leu Gln Tyr Gly Glu Gln Val Asn Glu Ile Leu Cys Arg Ser Ser
         995                1000                1005

 gtc tgg agt gcc ttc aaa gat cag aaa cat gat ttg ttc att tct gag     3309
 Val Trp Ser Ala Phe Lys Asp Gln Lys His Asp Leu Phe Ile Ser Glu
    1010                1015                1020

 tca caa aca gca gga tac ctc aca gga cct gga gtt gct ggc tac ctt     3357
 Ser Gln Thr Ala Gly Tyr Leu Thr Gly Pro Gly Val Ala Gly Tyr Leu
1025                1030                1035                1040

 acc gca ggt aca tct aca tca gtc atg tct aac ctg cca cct cct gta     3405
 Thr Ala Gly Thr Ser Thr Ser Val Met Ser Asn Leu Pro Pro Pro Val
                1045                1050                1055

 gac cat gag gca ggc gac ctt ggc tat cag act tga aata ttcacgagag     3455
 Asp His Glu Ala Gly Asp Leu Gly Tyr Gln Thr 
            1060                1065

 acaataaacg ctgaaaggcc agtgccaagt ccacattcct ccagctgata cgttgaagca   3515

 aactcttact gcctttctcc tggtttcatg acagtgttat tcctttttct ataaatatat   3575

 ttttaggaaa aaaagtcagt gatcctaatt gtatcacatt ataagaaagc actctgtgga   3635

 tcaacataag tgggtacaca agaatttttt ttttcttggt gtatgtaagc acatttgttc   3695

 ctttatatct gtttacaaaa ctgtgaatca aaaagacaaa actttcttcc tagtttttgt   3755

 aatttttttt ttgaactagc atgactgtag ggttgagcta cagtcaacaa aaattgggct   3815

 aagtcacttt tccccaggaa agaatatttc cctctcctgc atcaagtctg cgtggccatc   3875

 ctccccccac catccaagac tattaggttt tgtccctgca cccttcactg gcatcctcaa   3935

 tcattaacct tctgaaagct cacagtacac attagtatgt ataactggct ttaccaaatt   3995

 gaatgaaaag gagcttgtgc aaaaaaattt aaaaatggat gtcaagatgt tatgtaaaag   4055

 atgagtataa ttgtgaaatg ttctatacac tatcaaatat ataaagcttt ctatattgaa   4115

 tgtacattat acagatcatt catatgtgta cataaaattt taaaaataaa gggaattgac   4175

 tgctttgtta atgagaaaaa aaaaaaa                                       4202




      <210> 165
      <211> 953
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (304)..(801)

      <400> 165
 gggagctgga aatgcagcta ttgaggtctt cgaatgctgc ggacgtggag gcggaggcag     60

 ctggggaggt ccgagcgatg tgaccaggcc gccatcgctc gtctcttcct ctctcctgcc    120

 gcctcctgtc tcgaaaataa cttttttagt ctaaaaaaag aaagacaaaa gtagtcgtcc    180

 gcccctcacg ccctctcttc ctctcagcct tccgcccggt gaggaagccc ggggtggctg    240

 ctccgccgtc ggggccgcgc cgccgagccc cggccgcccc gggcgccccc gcacgccgcc    300

 ccc  atg cat ccc ttc tac acc cgg gcc gcc acc atg ata ggc gag atc     348
      Met His Pro Phe Tyr Thr Arg Ala Ala Thr Met Ile Gly Glu Ile
        1               5                  10                  15

 gcc gcc gcc gtg tcc ttc atc tcc aag ttt ctc cgc acc aag ggg ctc      396
 Ala Ala Ala Val Ser Phe Ile Ser Lys Phe Leu Arg Thr Lys Gly Leu
                  20                  25                  30

 acg agc gag cga cag ctg cag acc ttc agc cag agc ctg cag gag ctg      444
 Thr Ser Glu Arg Gln Leu Gln Thr Phe Ser Gln Ser Leu Gln Glu Leu
              35                  40                  45

 ctg gca gaa cat tat aaa cat cac tgg ttc cca gaa aag cca tgc aag      492
 Leu Ala Glu His Tyr Lys His His Trp Phe Pro Glu Lys Pro Cys Lys
          50                  55                  60

 gga tcg ggt tac cgt tgt att cgc atc aac cat aaa atg gat cct ctg      540
 Gly Ser Gly Tyr Arg Cys Ile Arg Ile Asn His Lys Met Asp Pro Leu
      65                  70                  75

 att gga cag gca gca cag cgg att gga ctg agc aga cag gag ctg ttc      588
 Ile Gly Gln Ala Ala Gln Arg Ile Gly Leu Ser Arg Gln Glu Leu Phe
  80                  85                  90                  95

 agg ctt ctc cca agt gaa ctc aca ctc tgg gtt gac ccc tat gaa gtg      636
 Arg Leu Leu Pro Ser Glu Leu Thr Leu Trp Val Asp Pro Tyr Glu Val
                 100                 105                 110

 tcc aca aga att gga gat gat ggc tcc atc tgt gtg ctg tat gaa gcc      684
 Ser Thr Arg Ile Gly Asp Asp Gly Ser Ile Cys Val Leu Tyr Glu Ala
             115                 120                 125

 tca cca gca gga ggt agc act caa aac agc tcc agc gtg caa atg gta      732
 Ser Pro Ala Gly Gly Ser Thr Gln Asn Ser Ser Ser Val Gln Met Val
         130                 135                 140

 gac tgc cga atc agc tgt aag gag gaa ctt ctc ttg ggc aga acg agc      780
 Asp Cys Arg Ile Ser Cys Lys Glu Glu Leu Leu Leu Gly Arg Thr Ser
     145                 150                 155

 cct tcc aaa act aca ata tga tg actgtatcag gttaagatat agtctgtgga      833
 Pro Ser Lys Thr Thr Ile 
 160                 165

 tggatcatct gatgatgatg gataaatttg atttttgctt tgggtgggct cctcttgggg    893

 atggattatg gaatttaaac catgtcacac gtttgaagaa cctgctcagg ttagaatggt    953




      <210> 166
      <211> 1943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1665)

      <400> 166
  atg gag tca tgg atg ctt cat tcc tca gaa ctc ttc cca aat atc ttc      48
  Met Glu Ser Trp Met Leu His Ser Ser Glu Leu Phe Pro Asn Ile Phe
    1               5                  10                  15

 tgc tat gct tcc tta tca atg gaa aaa ggc tgc ggc atg ttt acc ttc       96
 Cys Tyr Ala Ser Leu Ser Met Glu Lys Gly Cys Gly Met Phe Thr Phe
              20                  25                  30

 ctg tca tct gtc act gct gct gtc agt ggc ctc ctg gtg ggt tat gaa      144
 Leu Ser Ser Val Thr Ala Ala Val Ser Gly Leu Leu Val Gly Tyr Glu
          35                  40                  45

 ctt ggg atc atc tct ggg gct ctt ctt cag atc aaa acc tta tta gcc      192
 Leu Gly Ile Ile Ser Gly Ala Leu Leu Gln Ile Lys Thr Leu Leu Ala
      50                  55                  60

 ctg agc tgc cat gag cag gaa atg gtt gtg agc tcc ctc gtc att gga      240
 Leu Ser Cys His Glu Gln Glu Met Val Val Ser Ser Leu Val Ile Gly
  65                  70                  75                  80

 gcc ctc ctt gcc tca ctc acc gga ggg gtc ctg ata gac aga tat gga      288
 Ala Leu Leu Ala Ser Leu Thr Gly Gly Val Leu Ile Asp Arg Tyr Gly
                  85                  90                  95

 aga agg aca gca atc atc ttg tca tcc tgc ctg ctt gga ctc gga agc      336
 Arg Arg Thr Ala Ile Ile Leu Ser Ser Cys Leu Leu Gly Leu Gly Ser
             100                 105                 110

 tta gtc ttg atc ctc agt tta tcc tac acg gtt ctt ata gtg gga cgc      384
 Leu Val Leu Ile Leu Ser Leu Ser Tyr Thr Val Leu Ile Val Gly Arg
         115                 120                 125

 att gcc ata ggg gtc tcc atc tcc ctc tct tcc att gcc act tgt gtt      432
 Ile Ala Ile Gly Val Ser Ile Ser Leu Ser Ser Ile Ala Thr Cys Val
     130                 135                 140

 tac atc gca gag att gct cct caa cac aga aga ggc ctt ctt gtg tca      480
 Tyr Ile Ala Glu Ile Ala Pro Gln His Arg Arg Gly Leu Leu Val Ser
 145                 150                 155                 160

 ctg aat gag ctg atg att gtc atc ggc att ctt tct gcc tat att tca      528
 Leu Asn Glu Leu Met Ile Val Ile Gly Ile Leu Ser Ala Tyr Ile Ser
                 165                 170                 175

 aat tac gca ttt gcc aat gtt ttc cat ggc tgg aag tac atg ttt ggt      576
 Asn Tyr Ala Phe Ala Asn Val Phe His Gly Trp Lys Tyr Met Phe Gly
             180                 185                 190

 ctt gtg att ccc ttg gga gtt ttg caa gca att gca atg tat ttt ctt      624
 Leu Val Ile Pro Leu Gly Val Leu Gln Ala Ile Ala Met Tyr Phe Leu
         195                 200                 205

 cct cca agc cct cgg ttt ctg gtg atg aaa gga caa gag gga gct gct      672
 Pro Pro Ser Pro Arg Phe Leu Val Met Lys Gly Gln Glu Gly Ala Ala
     210                 215                 220

 agc aag gtt ctt gga agg tta aga gca ctc tca gat aca act gag gaa      720
 Ser Lys Val Leu Gly Arg Leu Arg Ala Leu Ser Asp Thr Thr Glu Glu
 225                 230                 235                 240

 ctc act gtg atc aaa tcc tcc ctg aaa gat gaa tat cag tac agt ttt      768
 Leu Thr Val Ile Lys Ser Ser Leu Lys Asp Glu Tyr Gln Tyr Ser Phe
                 245                 250                 255

 tgg gat ctg ttt cgt tca aaa gac aac atg cgg acc cga ata atg ata      816
 Trp Asp Leu Phe Arg Ser Lys Asp Asn Met Arg Thr Arg Ile Met Ile
             260                 265                 270

 gga cta aca cta gta ttt ttt gta caa atc act ggc caa cca aac ata      864
 Gly Leu Thr Leu Val Phe Phe Val Gln Ile Thr Gly Gln Pro Asn Ile
         275                 280                 285

 ttg ttc tat gca tca act gtt ttg aag tca gtt gga ttt caa agc aat      912
 Leu Phe Tyr Ala Ser Thr Val Leu Lys Ser Val Gly Phe Gln Ser Asn
     290                 295                 300

 gag gca gct agc ctc gcc tcc act ggg gtt gga gtc gtc aag gtc att      960
 Glu Ala Ala Ser Leu Ala Ser Thr Gly Val Gly Val Val Lys Val Ile
 305                 310                 315                 320

 agc acc atc cct gcc act ctt ctt gta gac cat gtc ggc agc aaa aca     1008
 Ser Thr Ile Pro Ala Thr Leu Leu Val Asp His Val Gly Ser Lys Thr
                 325                 330                 335

 ttc ctc tgc att ggc tcc tct gtg atg gca gct tcg ttg gtg acc atg     1056
 Phe Leu Cys Ile Gly Ser Ser Val Met Ala Ala Ser Leu Val Thr Met
             340                 345                 350

 ggc atc gta aat ctc aac atc cac atg aac ttc acc cat atc tgc aga     1104
 Gly Ile Val Asn Leu Asn Ile His Met Asn Phe Thr His Ile Cys Arg
         355                 360                 365

 agc cac aat tct atc aac cag tcc ttg gat gag tct gtg att tat gga     1152
 Ser His Asn Ser Ile Asn Gln Ser Leu Asp Glu Ser Val Ile Tyr Gly
     370                 375                 380

 cca gga aac ctg tca acc aac aac aat act ctc aga gac cac ttc aaa     1200
 Pro Gly Asn Leu Ser Thr Asn Asn Asn Thr Leu Arg Asp His Phe Lys
 385                 390                 395                 400

 ggg att tct tcc cat agc aga agc tca ctc atg ccc ctg aga aat gat     1248
 Gly Ile Ser Ser His Ser Arg Ser Ser Leu Met Pro Leu Arg Asn Asp
                 405                 410                 415

 gtg gat aag aga ggg gag acg acc tca gca tcc ttg cta aat gct gga     1296
 Val Asp Lys Arg Gly Glu Thr Thr Ser Ala Ser Leu Leu Asn Ala Gly
             420                 425                 430

 tta agc cac act gaa tac cag ata gtc aca gac cct ggg gac gtc cca     1344
 Leu Ser His Thr Glu Tyr Gln Ile Val Thr Asp Pro Gly Asp Val Pro
         435                 440                 445

 gct ttt ttg aaa tgg ctg tcc tta gcc agc ttg ctt gtt tat gtt gct     1392
 Ala Phe Leu Lys Trp Leu Ser Leu Ala Ser Leu Leu Val Tyr Val Ala
     450                 455                 460

 gct ttt tca att ggt cta gga cca atg ccc tgg ctg gtg ctc agc gag     1440
 Ala Phe Ser Ile Gly Leu Gly Pro Met Pro Trp Leu Val Leu Ser Glu
 465                 470                 475                 480

 atc ttt cct ggt ggg atc aga gga cga gcc atg gct tta act tct agc     1488
 Ile Phe Pro Gly Gly Ile Arg Gly Arg Ala Met Ala Leu Thr Ser Ser
                 485                 490                 495

 atg aac tgg ggc atc aat ctc ctc atc tcg ctg aca ttt ttg act gta     1536
 Met Asn Trp Gly Ile Asn Leu Leu Ile Ser Leu Thr Phe Leu Thr Val
             500                 505                 510

 act gat ctt att ggc ctg cca tgg gtg tgc ttt ata tat aca atc atg     1584
 Thr Asp Leu Ile Gly Leu Pro Trp Val Cys Phe Ile Tyr Thr Ile Met
         515                 520                 525

 agt cta gca tcc ctg ctt ttg ttg tta tgt tta tac ctg aga caa agg     1632
 Ser Leu Ala Ser Leu Leu Leu Leu Leu Cys Leu Tyr Leu Arg Gln Arg
     530                 535                 540

 gat gct ctt tgg aac aaa tat caa tgg agc tag caaaagtg aactatgtga     1683
 Asp Ala Leu Trp Asn Lys Tyr Gln Trp Ser 
 545                 550

 aaaacaacat ttgtttatga gtcatccacc aagaagaatt agtgcccaaa aacaggctcc   1743

 agaaaagaag accccaggag cagctcttgg aggtgttaac aacgctgtgt tggtaggggg   1803

 ccatccaggc agtttctcca gagactaaat ggctcacaac cttctgaagt gggtgtgccc   1863

 aaacccttcg gggtgccttg gaccaagctt tttggaaccg ggcccttcag gcctgcgccg   1923

 gtttgaggcc ctctagtaac                                               1943




      <210> 167
      <211> 1977
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1977)

      <400> 167
  atg gag tca tgg atg ctt cat tcc tca gaa ctc ttc cca aat atc ttc      48
  Met Glu Ser Trp Met Leu His Ser Ser Glu Leu Phe Pro Asn Ile Phe
    1               5                  10                  15

 tgc tat gct tcc tta tca atg gaa aaa ggc tgc ggc atg ttt acc ttc       96
 Cys Tyr Ala Ser Leu Ser Met Glu Lys Gly Cys Gly Met Phe Thr Phe
              20                  25                  30

 ctg tca tct gtc act gct gct gtc agt ggc ctc ctg gtg ggt tat gaa      144
 Leu Ser Ser Val Thr Ala Ala Val Ser Gly Leu Leu Val Gly Tyr Glu
          35                  40                  45

 ctt ggg atc atc tct ggg gct ctt ctt cag atc aaa acc tta tta gcc      192
 Leu Gly Ile Ile Ser Gly Ala Leu Leu Gln Ile Lys Thr Leu Leu Ala
      50                  55                  60

 ctg agc tgc cat gag cag gaa atg gtt gtg agc tcc ctc gtc att gga      240
 Leu Ser Cys His Glu Gln Glu Met Val Val Ser Ser Leu Val Ile Gly
  65                  70                  75                  80

 gcc ctc ctt gcc tca ctc acc gga ggg gtc ctg ata gac aga tat gga      288
 Ala Leu Leu Ala Ser Leu Thr Gly Gly Val Leu Ile Asp Arg Tyr Gly
                  85                  90                  95

 aga agg aca gca atc atc ttg tca tcc tgc ctg ctt gga ctc gga agc      336
 Arg Arg Thr Ala Ile Ile Leu Ser Ser Cys Leu Leu Gly Leu Gly Ser
             100                 105                 110

 tta gtc ttg atc ctc agt tta tcc tac acg gtt ctt ata gtg gga cgc      384
 Leu Val Leu Ile Leu Ser Leu Ser Tyr Thr Val Leu Ile Val Gly Arg
         115                 120                 125

 att gcc ata ggg gtc tcc atc tcc ctc tct tcc att gcc act tgt gtt      432
 Ile Ala Ile Gly Val Ser Ile Ser Leu Ser Ser Ile Ala Thr Cys Val
     130                 135                 140

 tac atc gca gag att gct cct caa cac aaa aaa ggc ctt ctt gtg tca      480
 Tyr Ile Ala Glu Ile Ala Pro Gln His Lys Lys Gly Leu Leu Val Ser
 145                 150                 155                 160

 ctg aat gag ctg atg att gtc atc ggc att ctt tct gcc tat att tca      528
 Leu Asn Glu Leu Met Ile Val Ile Gly Ile Leu Ser Ala Tyr Ile Ser
                 165                 170                 175

 aat tac gca ttt gcc aat gtt ttc cat ggc tgg aag tac atg ttt ggt      576
 Asn Tyr Ala Phe Ala Asn Val Phe His Gly Trp Lys Tyr Met Phe Gly
             180                 185                 190

 ctt gtg att ccc ttg gga gtt ttg caa gca att gca atg tat ttt ctt      624
 Leu Val Ile Pro Leu Gly Val Leu Gln Ala Ile Ala Met Tyr Phe Leu
         195                 200                 205

 cct cca agc cct cgg ttt ctg gtg atg aaa gga caa gag gga gct gct      672
 Pro Pro Ser Pro Arg Phe Leu Val Met Lys Gly Gln Glu Gly Ala Ala
     210                 215                 220

 agc aag gtt ctt gga agg tta aga gca ctc tca gat aca act gag gaa      720
 Ser Lys Val Leu Gly Arg Leu Arg Ala Leu Ser Asp Thr Thr Glu Glu
 225                 230                 235                 240

 ctc act gtg atc aaa tcc tcc ctg aaa gat gaa tat cag tac agt ttt      768
 Leu Thr Val Ile Lys Ser Ser Leu Lys Asp Glu Tyr Gln Tyr Ser Phe
                 245                 250                 255

 tgg gat ctg ttt cgt tca aaa gac aac atg cgg acc cga ata atg ata      816
 Trp Asp Leu Phe Arg Ser Lys Asp Asn Met Arg Thr Arg Ile Met Ile
             260                 265                 270

 gga cta aca cta gta ttt ttt gta caa atc act ggc caa cca aac ata      864
 Gly Leu Thr Leu Val Phe Phe Val Gln Ile Thr Gly Gln Pro Asn Ile
         275                 280                 285

 ttg ttc tat gca tca act gtt ttg aag tca gtt gga ttt caa agc aat      912
 Leu Phe Tyr Ala Ser Thr Val Leu Lys Ser Val Gly Phe Gln Ser Asn
     290                 295                 300

 gag gca gct agc ctc gcc tcc act ggg gtt gga gtc gtc aag gtc att      960
 Glu Ala Ala Ser Leu Ala Ser Thr Gly Val Gly Val Val Lys Val Ile
 305                 310                 315                 320

 agc acc atc cct gcc act ctt ctt gta gac cat gtc ggc agc aaa aca     1008
 Ser Thr Ile Pro Ala Thr Leu Leu Val Asp His Val Gly Ser Lys Thr
                 325                 330                 335

 ttc ctc tgc att ggc tcc tct gtg atg gca gct tcg ttg gtg acc atg     1056
 Phe Leu Cys Ile Gly Ser Ser Val Met Ala Ala Ser Leu Val Thr Met
             340                 345                 350

 ggc atc gta aat ctc aac atc cac atg aac ttc acc cat atc tgc aga     1104
 Gly Ile Val Asn Leu Asn Ile His Met Asn Phe Thr His Ile Cys Arg
         355                 360                 365

 agc cac aat tct atc aac cag tcc ttg gat gag tct gtg att tat gga     1152
 Ser His Asn Ser Ile Asn Gln Ser Leu Asp Glu Ser Val Ile Tyr Gly
     370                 375                 380

 cca gga aac ctg tca acc aac aac aat act ctc aga gac cac ttc aaa     1200
 Pro Gly Asn Leu Ser Thr Asn Asn Asn Thr Leu Arg Asp His Phe Lys
 385                 390                 395                 400

 ggg att tct tcc cat agc aga agc tca ctc atg ccc ctg aga aat gat     1248
 Gly Ile Ser Ser His Ser Arg Ser Ser Leu Met Pro Leu Arg Asn Asp
                 405                 410                 415

 gtg gat aag aga ggg gag acg acc tca gca tcc ttg cta aat gct gga     1296
 Val Asp Lys Arg Gly Glu Thr Thr Ser Ala Ser Leu Leu Asn Ala Gly
             420                 425                 430

 tta agc cac act gaa tac cag ata gtc aca gac cct ggg gac gtc cca     1344
 Leu Ser His Thr Glu Tyr Gln Ile Val Thr Asp Pro Gly Asp Val Pro
         435                 440                 445

 gct ttt ttg aaa tgg ctg tcc tta gcc agc ttg ctt gtt tat gtt gct     1392
 Ala Phe Leu Lys Trp Leu Ser Leu Ala Ser Leu Leu Val Tyr Val Ala
     450                 455                 460

 gct ttt tca att ggt cta gga cca aca ggg cag gcc gga gga aaa gct     1440
 Ala Phe Ser Ile Gly Leu Gly Pro Thr Gly Gln Ala Gly Gly Lys Ala
 465                 470                 475                 480

 gga ctc aaa gca gag gga agc aga gac gac tca ctg aat ccg gta gac     1488
 Gly Leu Lys Ala Glu Gly Ser Arg Asp Asp Ser Leu Asn Pro Val Asp
                 485                 490                 495

 aaa ctg gaa tcc atg gga gga aac tgc agc act cat gtc ttt cgc cac     1536
 Lys Leu Glu Ser Met Gly Gly Asn Cys Ser Thr His Val Phe Arg His
             500                 505                 510

 atc act cca gag gaa cct ggg ctt gaa ggt gaa gaa cag tgt gga atc     1584
 Ile Thr Pro Glu Glu Pro Gly Leu Glu Gly Glu Glu Gln Cys Gly Ile
         515                 520                 525

 aga gtc cta att agt tac cgg cta gac ttt gat aag tcc ctt aag cac     1632
 Arg Val Leu Ile Ser Tyr Arg Leu Asp Phe Asp Lys Ser Leu Lys His
     530                 535                 540

 aaa cta aat gag cag gaa gag gca gca aaa agc gta caa tgt att tgt     1680
 Lys Leu Asn Glu Gln Glu Glu Ala Ala Lys Ser Val Gln Cys Ile Cys
 545                 550                 555                 560

 ggg aat tgt aaa tgt gga agt gaa gac cag cct ctg att tat caa aga     1728
 Gly Asn Cys Lys Cys Gly Ser Glu Asp Gln Pro Leu Ile Tyr Gln Arg
                 565                 570                 575

 tca tta aat gaa tta aaa ctt ttc caa att tca cct tca gaa gag aaa     1776
 Ser Leu Asn Glu Leu Lys Leu Phe Gln Ile Ser Pro Ser Glu Glu Lys
             580                 585                 590

 aaa gtg atc atg gat cca gta aaa gcc atc gac ttg cca aga tgc atc     1824
 Lys Val Ile Met Asp Pro Val Lys Ala Ile Asp Leu Pro Arg Cys Ile
         595                 600                 605

 aca aga agc agg atc ctc aag att ctg atg act ctc atc tgc aaa cct     1872
 Thr Arg Ser Arg Ile Leu Lys Ile Leu Met Thr Leu Ile Cys Lys Pro
     610                 615                 620

 agt ttt tcc tct gac cgc ttc cag cca aag ata cag tcc ctt tgt agt     1920
 Ser Phe Ser Ser Asp Arg Phe Gln Pro Lys Ile Gln Ser Leu Cys Ser
 625                 630                 635                 640

 cat gga cca agt caa ggc aca ttc agt ggt cag cag tgg ccc cca cag     1968
 His Gly Pro Ser Gln Gly Thr Phe Ser Gly Gln Gln Trp Pro Pro Gln
                 645                 650                 655

 tgc act tga                                                         1977
 Cys Thr 






      <210> 168
      <211> 2775
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (277)..(2064)

      <400> 168
 gcacgagctc tctggagtcg attgccccga gacacatggg ccaaggaggg gtcagcggcg     60

 aattctttcg gcctgttggg gacccctcgt gtccccacgc cagactggac ctcccgtatg    120

 aacttctctt cgcatcggcg gcggcttccg tcacctccgc tcccccgatc ctattcccag    180

 tcgtatgcca gcttggagag tcacgtgaga gcaagagagt agctttctgg ttgtcctggt    240

 gccctgctca ggcaaactga ctgccattct ctgagg  atg gca gct ctg tcc ccc     294
                                          Met Ala Ala Leu Ser Pro
                                            1               5

 aca ttt gcc acg tcc acc cag gat tcc acc tgt ctc cag gac tca gaa      342
 Thr Phe Ala Thr Ser Thr Gln Asp Ser Thr Cys Leu Gln Asp Ser Glu
              10                  15                  20

 ttt cct gtt tct tca aaa gac cat tcc tgt ccc cag aat ttg gac ctg      390
 Phe Pro Val Ser Ser Lys Asp His Ser Cys Pro Gln Asn Leu Asp Leu
          25                  30                  35

 ttc gtg tgc agt ggt ctg gag cct cac aca ccc agt gtt ggt tcc cag      438
 Phe Val Cys Ser Gly Leu Glu Pro His Thr Pro Ser Val Gly Ser Gln
      40                  45                  50

 gaa tcg gtg act ttc caa gat gtc gct gtg gac ttt acc gag aag gag      486
 Glu Ser Val Thr Phe Gln Asp Val Ala Val Asp Phe Thr Glu Lys Glu
  55                  60                  65                  70

 tgg ccc ttg ctg gat tct tct cag aga aaa ctg tac aaa gat gta atg      534
 Trp Pro Leu Leu Asp Ser Ser Gln Arg Lys Leu Tyr Lys Asp Val Met
                  75                  80                  85

 ctg gag aac tac agc aac ctc act tca ctg ggg tat cag gtc ggc aaa      582
 Leu Glu Asn Tyr Ser Asn Leu Thr Ser Leu Gly Tyr Gln Val Gly Lys
              90                  95                 100

 ccc agc ctc atc tca cac ttg gag cag gag gag gag ccg agg aca gag      630
 Pro Ser Leu Ile Ser His Leu Glu Gln Glu Glu Glu Pro Arg Thr Glu
         105                 110                 115

 gag agg ggc gct cac cag ggc gct tgt gca gat tgg gag act cca tct      678
 Glu Arg Gly Ala His Gln Gly Ala Cys Ala Asp Trp Glu Thr Pro Ser
     120                 125                 130

 aaa acc aag tgg tca ctt ctt atg gaa gat att ttt ggg aag gaa acg      726
 Lys Thr Lys Trp Ser Leu Leu Met Glu Asp Ile Phe Gly Lys Glu Thr
 135                 140                 145                 150

 ccc agt ggt gtg acg atg gaa aga gcc ggt ctt gga gag aag tcc act      774
 Pro Ser Gly Val Thr Met Glu Arg Ala Gly Leu Gly Glu Lys Ser Thr
                 155                 160                 165

 gaa tac gct cac ttg ttc gaa gtc ttt ggc atg gac cct cat ctc act      822
 Glu Tyr Ala His Leu Phe Glu Val Phe Gly Met Asp Pro His Leu Thr
             170                 175                 180

 cag cca atg gga agg cac gct ggc aag agg ccc tat cac cgc cgc gac      870
 Gln Pro Met Gly Arg His Ala Gly Lys Arg Pro Tyr His Arg Arg Asp
         185                 190                 195

 tat ggg gta gcg ttc aag ggc agg ccg cac ctc act cag cac atg agc      918
 Tyr Gly Val Ala Phe Lys Gly Arg Pro His Leu Thr Gln His Met Ser
     200                 205                 210

 atg tac gac ggg aga aaa atg cat gaa tgt cat cag tgc caa aaa gcc      966
 Met Tyr Asp Gly Arg Lys Met His Glu Cys His Gln Cys Gln Lys Ala
 215                 220                 225                 230

 ttc acc acg agc gcg tcc ctc aca cgg cac agg aga atc cac acc ggg     1014
 Phe Thr Thr Ser Ala Ser Leu Thr Arg His Arg Arg Ile His Thr Gly
                 235                 240                 245

 gag aag cct tac gag tgc agc gac tgc ggg aaa gcc ttc aac gac cct     1062
 Glu Lys Pro Tyr Glu Cys Ser Asp Cys Gly Lys Ala Phe Asn Asp Pro
             250                 255                 260

 tca gcc ctt agg agc cac gca aga act cac ctc aaa gag aag ccc ttt     1110
 Ser Ala Leu Arg Ser His Ala Arg Thr His Leu Lys Glu Lys Pro Phe
         265                 270                 275

 gac tgc agt cag tgt gga aat gca ttc cgg acc ctc tcg gcc ctg aaa     1158
 Asp Cys Ser Gln Cys Gly Asn Ala Phe Arg Thr Leu Ser Ala Leu Lys
     280                 285                 290

 atc cac atg cga gtt cac act ggc gag agg cct tac aag tgt gat cag     1206
 Ile His Met Arg Val His Thr Gly Glu Arg Pro Tyr Lys Cys Asp Gln
 295                 300                 305                 310

 tgc ggg aag gct tac ggc cgg agc tgc cac ctc atc gca cac aag aga     1254
 Cys Gly Lys Ala Tyr Gly Arg Ser Cys His Leu Ile Ala His Lys Arg
                 315                 320                 325

 acg cac acc gga gag agg ccc tac gag tgt cac gac tgt ggg aaa gct     1302
 Thr His Thr Gly Glu Arg Pro Tyr Glu Cys His Asp Cys Gly Lys Ala
             330                 335                 340

 ttc cag cac ccc tcc cac ctc aaa gag cac gtg agg aat cac acg ggg     1350
 Phe Gln His Pro Ser His Leu Lys Glu His Val Arg Asn His Thr Gly
         345                 350                 355

 gag aag ccc tac gcg tgc acg cag tgc ggc aaa gcc ttc cgc tgg aag     1398
 Glu Lys Pro Tyr Ala Cys Thr Gln Cys Gly Lys Ala Phe Arg Trp Lys
     360                 365                 370

 tcc aac ttt aat ttg cac aag aag aac cac atg gtg gag aag acc tac     1446
 Ser Asn Phe Asn Leu His Lys Lys Asn His Met Val Glu Lys Thr Tyr
 375                 380                 385                 390

 gaa tgt aaa gaa tgc ggg aaa tcc ttt ggc gat ctc gtg tcc cgg agg     1494
 Glu Cys Lys Glu Cys Gly Lys Ser Phe Gly Asp Leu Val Ser Arg Arg
                 395                 400                 405

 aaa cac atg agg att cac atc gtc aag aaa ccc gtg gaa tgt cgg cag     1542
 Lys His Met Arg Ile His Ile Val Lys Lys Pro Val Glu Cys Arg Gln
             410                 415                 420

 tgc ggg aag acc ttc cga aac cag tcc atc ctt aag act cac atg aac     1590
 Cys Gly Lys Thr Phe Arg Asn Gln Ser Ile Leu Lys Thr His Met Asn
         425                 430                 435

 tct cac act gga gag aaa cca tac ggg tgc gat ctc tgc ggg aaa gct     1638
 Ser His Thr Gly Glu Lys Pro Tyr Gly Cys Asp Leu Cys Gly Lys Ala
     440                 445                 450

 ttc agc gcg agt tca aac ctc acc gca cac agg aag ata cac acg caa     1686
 Phe Ser Ala Ser Ser Asn Leu Thr Ala His Arg Lys Ile His Thr Gln
 455                 460                 465                 470

 gag aga cgc tac gaa tgc gcc gcc tgc ggg aaa gtc ttc ggt gac tat     1734
 Glu Arg Arg Tyr Glu Cys Ala Ala Cys Gly Lys Val Phe Gly Asp Tyr
                 475                 480                 485

 tta tcc cgg cgg agg cac atg agc gtt cac ctt gta aag aaa cga gtt     1782
 Leu Ser Arg Arg Arg His Met Ser Val His Leu Val Lys Lys Arg Val
             490                 495                 500

 gag tgt agg cag tgt ggc aag gcc ttc agg aac cag tca acg ctg aag     1830
 Glu Cys Arg Gln Cys Gly Lys Ala Phe Arg Asn Gln Ser Thr Leu Lys
         505                 510                 515

 acg cac atg cga agc cac acg ggg gag aaa ccg tac gaa tgc gat cac     1878
 Thr His Met Arg Ser His Thr Gly Glu Lys Pro Tyr Glu Cys Asp His
     520                 525                 530

 tgt ggg aag gcc ttc agc ata ggc tcc aac ctg aat gtg cac agg cgg     1926
 Cys Gly Lys Ala Phe Ser Ile Gly Ser Asn Leu Asn Val His Arg Arg
 535                 540                 545                 550

 atc cac acc ggg gag aag ccc tac gaa tgc ctt gtc tgc ggg aaa gcc     1974
 Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Leu Val Cys Gly Lys Ala
                 555                 560                 565

 ttc agc gac cac tca tcc ctc agg agc cac gtg aaa act cac cgg gga     2022
 Phe Ser Asp His Ser Ser Leu Arg Ser His Val Lys Thr His Arg Gly
             570                 575                 580

 gag aag ctc ttt gtg tca tcc gtg tgg aaa agg ctc cag tga gcgcgcc     2071
 Glu Lys Leu Phe Val Ser Ser Val Trp Lys Arg Leu Gln 
         585                 590                 595

 tgctttagag acacaggatg attcagaccg gaaacagacc tcgtgggtgt aagaggaagc   2131

 ctctgtgagc tcgcacctta ctgggtgcaa aagaatccac ggaacttggg agaagtccag   2191

 ttcctgtaaa aactgggaag acgaggcgtt ctcatcccat aggaggtttg tgagaactca   2251

 cgccgggggt gaaaatgtac gtctgtagca tggagaagcc ttcagggtac attcagctct   2311

 taacaaacac aggaggactt aatggcagct tggcatttaa tgtcaaaatc caagccgtgg   2371

 catttaatgt caaaatgact tcagaccact tctagccttc tgggcccatg agtaataatg   2431

 agcacactag ggagcatctc tgtaaacaca gtggctgggg aaacccttcc tagtctcact   2491

 tgattcctca tgacggaaat cacactaaag agagaaatca gtgaagtaag gaacgtggaa   2551

 ggtcatgaat gggccgcaaa ccacggccag ctgcttgtct ttgtatggct tgccagctaa   2611

 caatagtggt tccatcttta aggaagaaga atgtttgatg gagaaaattt gtggccaatg   2671

 aagtctgaaa tacttcctgt catctgcccc tttccagaaa aacttggccg acccttggtc   2731

 tacagcacgg gttctcagtc gggcgacgat ttggctgtct aggc                    2775




      <210> 169
      <211> 2023
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (150)..(2009)

      <400> 169
 cggacgcgtg ggtgtaaatc cggctggact ttcagcttct aagaacagtc cgtttctcga     60

 ggatccaggc gcaggaggac agagcaatgg gtgagagaac tcttcacgct gcagtgccca    120

 caccaggtta tccagaatct gaatccatc  atg atg gcc ccc att tgt cta gtg     173
                                  Met Met Ala Pro Ile Cys Leu Val
                                    1               5

 gaa aac cag gaa gag cag ctg aca gtg aat tca aag gca tta gag att      221
 Glu Asn Gln Glu Glu Gln Leu Thr Val Asn Ser Lys Ala Leu Glu Ile
      10                  15                  20

 ctt gac aag att tct cag ccc gtg gtg gtg gtg gcc att gta ggg cta      269
 Leu Asp Lys Ile Ser Gln Pro Val Val Val Val Ala Ile Val Gly Leu
  25                  30                  35                  40

 tac cgc aca gga aaa tcc tat ctc atg aat cgt ctt gca gga aag cgc      317
 Tyr Arg Thr Gly Lys Ser Tyr Leu Met Asn Arg Leu Ala Gly Lys Arg
                  45                  50                  55

 aat ggc ttc cct ctg ggc tcc acg gtg cag tct gaa act aag ggc atc      365
 Asn Gly Phe Pro Leu Gly Ser Thr Val Gln Ser Glu Thr Lys Gly Ile
              60                  65                  70

 tgg atg tgg tgt gtg ccc cac ctc tct aag cca aac cac acc ctg gtc      413
 Trp Met Trp Cys Val Pro His Leu Ser Lys Pro Asn His Thr Leu Val
          75                  80                  85

 ctt ctg gac acc gag ggc ctg ggc gat gta gaa aag agt aac cct aag      461
 Leu Leu Asp Thr Glu Gly Leu Gly Asp Val Glu Lys Ser Asn Pro Lys
      90                  95                 100

 aat gac tcg tgg atc ttt gcc ctg gct gtg ctt cta agc agc agc ttt      509
 Asn Asp Ser Trp Ile Phe Ala Leu Ala Val Leu Leu Ser Ser Ser Phe
 105                 110                 115                 120

 gtc tat aac agc gtg agc acc atc aac cac cag gcc ctg gag cag ctg      557
 Val Tyr Asn Ser Val Ser Thr Ile Asn His Gln Ala Leu Glu Gln Leu
                 125                 130                 135

 cac tat gtg act gag cta gca gag cta atc agg gca aaa tcc tgc ccc      605
 His Tyr Val Thr Glu Leu Ala Glu Leu Ile Arg Ala Lys Ser Cys Pro
             140                 145                 150

 aga cct gat gaa gct gag gac tcc agc gag ttt gcg agt ttc ttt cca      653
 Arg Pro Asp Glu Ala Glu Asp Ser Ser Glu Phe Ala Ser Phe Phe Pro
         155                 160                 165

 gac ttt att tgg act gtt cgg gat ttt acc ctg gag cta aag tta gat      701
 Asp Phe Ile Trp Thr Val Arg Asp Phe Thr Leu Glu Leu Lys Leu Asp
     170                 175                 180

 gga aac ccc atc aca gaa gat gag tac ctg gag aat gcc ttg aag ctg      749
 Gly Asn Pro Ile Thr Glu Asp Glu Tyr Leu Glu Asn Ala Leu Lys Leu
 185                 190                 195                 200

 att cca ggc aag aat ccc aaa att caa aat tca aac atg cct aga gag      797
 Ile Pro Gly Lys Asn Pro Lys Ile Gln Asn Ser Asn Met Pro Arg Glu
                 205                 210                 215

 tgt atc agg cat ttc ttc cga aaa cgg aag tgc ttt gtc ttt gac cgg      845
 Cys Ile Arg His Phe Phe Arg Lys Arg Lys Cys Phe Val Phe Asp Arg
             220                 225                 230

 cct aca aat gac aag caa tat tta aat cat atg gac gaa gtg cca gaa      893
 Pro Thr Asn Asp Lys Gln Tyr Leu Asn His Met Asp Glu Val Pro Glu
         235                 240                 245

 gaa aat ctg gaa agg cat ttc ctt atg caa tca gac aac ttc tgt tct      941
 Glu Asn Leu Glu Arg His Phe Leu Met Gln Ser Asp Asn Phe Cys Ser
     250                 255                 260

 tat atc ttc acc cat gca aag acc aag acc ctg aga gag gga atc att      989
 Tyr Ile Phe Thr His Ala Lys Thr Lys Thr Leu Arg Glu Gly Ile Ile
 265                 270                 275                 280

 gtc act gga aag cgg ctg ggg act ctg gtg gtg act tat gta gat gcc     1037
 Val Thr Gly Lys Arg Leu Gly Thr Leu Val Val Thr Tyr Val Asp Ala
                 285                 290                 295

 atc aac agt gga gca gta cct tgt ctg gag aat gca gtg aca gca ctg     1085
 Ile Asn Ser Gly Ala Val Pro Cys Leu Glu Asn Ala Val Thr Ala Leu
             300                 305                 310

 gcc cag ctt gag aac cca gcg gct gtg cag agg gca gcc gac cac tat     1133
 Ala Gln Leu Glu Asn Pro Ala Ala Val Gln Arg Ala Ala Asp His Tyr
         315                 320                 325

 agc cag cag atg gcc cag caa ctg agg ctc ccc aca gac acg ctc cag     1181
 Ser Gln Gln Met Ala Gln Gln Leu Arg Leu Pro Thr Asp Thr Leu Gln
     330                 335                 340

 gag ctg ctg gac gtg cat gca gcc tgt gag agg gaa gcc att gca gtc     1229
 Glu Leu Leu Asp Val His Ala Ala Cys Glu Arg Glu Ala Ile Ala Val
 345                 350                 355                 360

 ttc atg gag cac tcc ttc aag gat gaa aac cat gaa ttc cag aag aag     1277
 Phe Met Glu His Ser Phe Lys Asp Glu Asn His Glu Phe Gln Lys Lys
                 365                 370                 375

 ctt gtg gac acc ata gag aaa aag aag gga gac ttt gtg ctg cag aat     1325
 Leu Val Asp Thr Ile Glu Lys Lys Lys Gly Asp Phe Val Leu Gln Asn
             380                 385                 390

 gaa gag gca tct gcc aaa tat tgc cag gct gag ctt aag cgg ctt tca     1373
 Glu Glu Ala Ser Ala Lys Tyr Cys Gln Ala Glu Leu Lys Arg Leu Ser
         395                 400                 405

 gag cac ctg aca gaa agc att ttg aga gga att ttc tct gtt cct gga     1421
 Glu His Leu Thr Glu Ser Ile Leu Arg Gly Ile Phe Ser Val Pro Gly
     410                 415                 420

 gga cac aat ctc tac tta gaa gaa aag aaa cag gtt gag tgg gac tat     1469
 Gly His Asn Leu Tyr Leu Glu Glu Lys Lys Gln Val Glu Trp Asp Tyr
 425                 430                 435                 440

 aag cta gtg ccc aga aaa gga gtt aag gca aac gag gtc ctc cag aac     1517
 Lys Leu Val Pro Arg Lys Gly Val Lys Ala Asn Glu Val Leu Gln Asn
                 445                 450                 455

 ttc ctg cag tca cag gtg gtt gta gag gaa tcc atc ctg cag tca gac     1565
 Phe Leu Gln Ser Gln Val Val Val Glu Glu Ser Ile Leu Gln Ser Asp
             460                 465                 470

 aaa gcc ctc act gct gga gag aag gcc ata gca gcg gag cgg gcc atg     1613
 Lys Ala Leu Thr Ala Gly Glu Lys Ala Ile Ala Ala Glu Arg Ala Met
         475                 480                 485

 aag gaa gca gct gag aag gaa cag gag ctg cta aga gaa aaa cag aag     1661
 Lys Glu Ala Ala Glu Lys Glu Gln Glu Leu Leu Arg Glu Lys Gln Lys
     490                 495                 500

 gag cag cag caa atg atg gag gct caa gag aga agc ttc cag gaa tac     1709
 Glu Gln Gln Gln Met Met Glu Ala Gln Glu Arg Ser Phe Gln Glu Tyr
 505                 510                 515                 520

 atg gcc caa atg gag aag aag ttg gag gag gaa agg gaa aac ctt ctc     1757
 Met Ala Gln Met Glu Lys Lys Leu Glu Glu Glu Arg Glu Asn Leu Leu
                 525                 530                 535

 aga gag cat gaa agg ctg cta aaa cac aag ctg aag gta caa gaa gaa     1805
 Arg Glu His Glu Arg Leu Leu Lys His Lys Leu Lys Val Gln Glu Glu
             540                 545                 550

 atg ctt aag gaa gaa ttt caa aag aaa tct gag cag tta aat aaa gag     1853
 Met Leu Lys Glu Glu Phe Gln Lys Lys Ser Glu Gln Leu Asn Lys Glu
         555                 560                 565

 att aat caa ctg aaa gaa aaa att gaa agc act aaa aat gaa cag tta     1901
 Ile Asn Gln Leu Lys Glu Lys Ile Glu Ser Thr Lys Asn Glu Gln Leu
     570                 575                 580

 agg ctc tta aag atc ctt gac atg gct agc aac ata atg att gtc act     1949
 Arg Leu Leu Lys Ile Leu Asp Met Ala Ser Asn Ile Met Ile Val Thr
 585                 590                 595                 600

 cta cct ggg gct tcc aag cta ctt gga gta ggg aca aaa tat ctt ggc     1997
 Leu Pro Gly Ala Ser Lys Leu Leu Gly Val Gly Thr Lys Tyr Leu Gly
                 605                 610                 615

 tca cgt att taa gagcctgaat attc                                     2023
 Ser Arg Ile 






      <210> 170
      <211> 1851
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (19)..(699)

      <400> 170
 gggagtcggc ggcacaaa  atg gcg gcg gcg gcg gcg gcg gct ggt gct gca      51
                      Met Ala Ala Ala Ala Ala Ala Ala Gly Ala Ala
                        1               5                  10

 ggg tcg gca gct ccc gcg gca gcg gcc ggc gcc ccg gga tct ggg ggc       99
 Gly Ser Ala Ala Pro Ala Ala Ala Ala Gly Ala Pro Gly Ser Gly Gly
              15                  20                  25

 gca ccc tca ggg tcg cag ggg gtg ctg atc ggg gac agg ctg tac tcc      147
 Ala Pro Ser Gly Ser Gln Gly Val Leu Ile Gly Asp Arg Leu Tyr Ser
          30                  35                  40

 ggg gtg ctc atc acc ttg gag aac tgc ctc ctg cct gac gac aag ctc      195
 Gly Val Leu Ile Thr Leu Glu Asn Cys Leu Leu Pro Asp Asp Lys Leu
      45                  50                  55

 cgt ttc acg ccg tcc atg tcg agc ggc ctc gac acc gac aca gag acc      243
 Arg Phe Thr Pro Ser Met Ser Ser Gly Leu Asp Thr Asp Thr Glu Thr
  60                  65                  70                  75

 gac ctc cgc gtg gtg ggc tgc gag ctc atc cag gcg gcc ggt atc ctg      291
 Asp Leu Arg Val Val Gly Cys Glu Leu Ile Gln Ala Ala Gly Ile Leu
                  80                  85                  90

 ctc cgc ctg ccg cag gtg gcc atg gct acc ggg cag gtg ttg ttc cag      339
 Leu Arg Leu Pro Gln Val Ala Met Ala Thr Gly Gln Val Leu Phe Gln
              95                 100                 105

 cgg ttc ttt tat acc aag tcc ttc gtg aag cac tcc atg gag cat gtg      387
 Arg Phe Phe Tyr Thr Lys Ser Phe Val Lys His Ser Met Glu His Val
         110                 115                 120

 tca atg gcc tgt gtc cac ctg gct tcc aag ata gaa gag gcc cca aga      435
 Ser Met Ala Cys Val His Leu Ala Ser Lys Ile Glu Glu Ala Pro Arg
     125                 130                 135

 cgc ata cgg gac gtc atc aat gtg ttt cac cgc ctt cga cag ctg aga      483
 Arg Ile Arg Asp Val Ile Asn Val Phe His Arg Leu Arg Gln Leu Arg
 140                 145                 150                 155

 gac aaa aag aag ccc gtg cct cta cta ctg gat caa gat tat gtt aat      531
 Asp Lys Lys Lys Pro Val Pro Leu Leu Leu Asp Gln Asp Tyr Val Asn
                 160                 165                 170

 tta aag aac caa att ata aag gcg gaa aga cga gtt ctc aaa gag ttg      579
 Leu Lys Asn Gln Ile Ile Lys Ala Glu Arg Arg Val Leu Lys Glu Leu
             175                 180                 185

 ggt ttc tgc gtc cat gtg aag cat cct cat aag ata atc gtt atg tac      627
 Gly Phe Cys Val His Val Lys His Pro His Lys Ile Ile Val Met Tyr
         190                 195                 200

 ctt cag gtg tta gag tgt gag cgt aac caa cac ctg gtc cag acc tca      675
 Leu Gln Val Leu Glu Cys Glu Arg Asn Gln His Leu Val Gln Thr Ser
     205                 210                 215

 tgg gta gcc tct gag ggt aag tga ctaagacttc tcctctgctg tccaagcgct     729
 Trp Val Ala Ser Glu Gly Lys 
 220                 225

 ttggtgcagg gacagcggca tcttcagcca atccagtgca ggctctccac cgaaggctgg    789

 ctctagactg gtggtacgca catagcatag ccatggccga ctcctgctgt ggttctctga    849

 cgattgtgct tcttgttaat cctctgtcgt gctttggtaa tcgtattgat tagagttggt    909

 aactgtcttg acttgaattt tgtcccttta aaactgctgt acctgtatga taaagatgca    969

 gtacctttct cttaaaaaaa aatgctatgg aaagctgtga gaattgaaga gacaaattgg   1029

 ctgtgtcagt gtggggttat gtcatgattt ctagaagccc tgaagttgct cttttgagca   1089

 gctttgcatg acacgctctg gtaaaaggtg tgcatcttta aattatttca tggatacttt   1149

 gaaaaatatt gtatcacttc aaatacagca ataagttata tggtctcaag atttcatttg   1209

 tttttaagaa ttttaagttc gtggattaat atcactactt gaatactgac agttgttgat   1269

 tagacaccga aaggttactg attgttgaat gtatctgtgt tagagctgtg cactggcacg   1329

 cttgcatcag gggctggggc cacacggccg ccacacagat tcccccgtga tgcctggagc   1389

 tgcttccaga gccgggtgtc tccaagaggc acctgtagga cttcccattt agaaatctct   1449

 tgagtgggtt tgtatgttac cttctccaag gtttatttag gacagagata ttgctggaag   1509

 gtcatgggtc agattccctc acaacccacc tcgtctgcgg gtgcagcccc actccaaggc   1569

 tccccgttat tggggtatgt gaggagcagt aaatataaaa ccagttcaac tgtcctcatg   1629

 gaatcaccct ttctgttttt gcagtattca taaagctagt gtaaggtctg gttttagtct   1689

 attaaatctt agagatctaa aggaaatgct caaaatgtag ccaggtttta aatgctttaa   1749

 cttttaaaaa atgtaaattt ttgtatgttt atagcttcta aatatgaaag ttaaagaatg   1809

 tactgtgatg aaatgtcagt attatgttgc ttctcagtat ca                      1851




      <210> 171
      <211> 2303
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (81)..(2078)

      <400> 171
 cccattgcgg tggaattccg tgagtcgctg cggggctgac ggggtggcag tgcggcgggt     60

 tacggcctgg tcagaccata    atg act tca gca aat aaa gca atc gaa tta     110
                          Met Thr Ser Ala Asn Lys Ala Ile Glu Leu
                            1               5                  10

 caa cta caa gtg aaa caa aat gca gaa gaa tta caa gac ttt atg cgg      158
 Gln Leu Gln Val Lys Gln Asn Ala Glu Glu Leu Gln Asp Phe Met Arg
                  15                  20                  25

 gat tta gaa aac tgg gaa aaa gac att aaa caa aag gat atg gaa cta      206
 Asp Leu Glu Asn Trp Glu Lys Asp Ile Lys Gln Lys Asp Met Glu Leu
              30                  35                  40

 aga aga cag aat ggt gtt cct gaa gag aat tta cct cct att cga aat      254
 Arg Arg Gln Asn Gly Val Pro Glu Glu Asn Leu Pro Pro Ile Arg Asn
          45                  50                  55

 ggg aat ttt agg aaa aag aag aaa ggc aaa gct aaa gag tct tcc aaa      302
 Gly Asn Phe Arg Lys Lys Lys Lys Gly Lys Ala Lys Glu Ser Ser Lys
      60                  65                  70

 aaa acc aga gag gaa aac aca aaa aac agg ata aaa tct tat gat tat      350
 Lys Thr Arg Glu Glu Asn Thr Lys Asn Arg Ile Lys Ser Tyr Asp Tyr
  75                  80                  85                  90

 gag gca tgg gca aaa ctt gat gtg gac cgt atc ctt gat gag ctt gac      398
 Glu Ala Trp Ala Lys Leu Asp Val Asp Arg Ile Leu Asp Glu Leu Asp
                  95                 100                 105

 aaa gac gat agt acc cat gag tct ctg tct caa gaa tca gag tcg gaa      446
 Lys Asp Asp Ser Thr His Glu Ser Leu Ser Gln Glu Ser Glu Ser Glu
             110                 115                 120

 gaa gat ggg att cat gta gat tca caa aag gct ctt gtt tta aaa gaa      494
 Glu Asp Gly Ile His Val Asp Ser Gln Lys Ala Leu Val Leu Lys Glu
         125                 130                 135

 aag ggc aat aaa tac ttc aaa caa gga aaa tat gat gaa gca att gac      542
 Lys Gly Asn Lys Tyr Phe Lys Gln Gly Lys Tyr Asp Glu Ala Ile Asp
     140                 145                 150

 tgc tac aca aaa ggc atg gat gcc gat cca tat aat ccc gtg ttg cca      590
 Cys Tyr Thr Lys Gly Met Asp Ala Asp Pro Tyr Asn Pro Val Leu Pro
 155                 160                 165                 170

 acg aac aga gcg tca gca tat ttt aga ctg aaa aaa ttt gct gtt gct      638
 Thr Asn Arg Ala Ser Ala Tyr Phe Arg Leu Lys Lys Phe Ala Val Ala
                 175                 180                 185

 gag tct gat tgt aat tta gca gtt gcc ttg aat aga agt tat aca aag      686
 Glu Ser Asp Cys Asn Leu Ala Val Ala Leu Asn Arg Ser Tyr Thr Lys
             190                 195                 200

 gct tat tcc aga cga ggt gct gct cga ttt gct ttg caa aaa tta gaa      734
 Ala Tyr Ser Arg Arg Gly Ala Ala Arg Phe Ala Leu Gln Lys Leu Glu
         205                 210                 215

 gag gcc aaa aaa gat tat gaa aga gta tta gaa cta gaa cca aat aac      782
 Glu Ala Lys Lys Asp Tyr Glu Arg Val Leu Glu Leu Glu Pro Asn Asn
     220                 225                 230

 ttt gaa gca aca aat gaa ctc agg aaa atc agt cag gct tta gca tcc      830
 Phe Glu Ala Thr Asn Glu Leu Arg Lys Ile Ser Gln Ala Leu Ala Ser
 235                 240                 245                 250

 aaa gaa aac tca tat cca aag gaa gct gac ata gtg att aag tca aca      878
 Lys Glu Asn Ser Tyr Pro Lys Glu Ala Asp Ile Val Ile Lys Ser Thr
                 255                 260                 265

 gaa gga gag cga aag caa att gaa gca caa cag aat aag cag cag gcc      926
 Glu Gly Glu Arg Lys Gln Ile Glu Ala Gln Gln Asn Lys Gln Gln Ala
             270                 275                 280

 att tca gag aaa gat cgg ggg aat gga ttt ttc aaa gag ggg aaa tat      974
 Ile Ser Glu Lys Asp Arg Gly Asn Gly Phe Phe Lys Glu Gly Lys Tyr
         285                 290                 295

 gaa aga gca att gaa tgc tat act cga ggg ata gca gca gat ggt gct     1022
 Glu Arg Ala Ile Glu Cys Tyr Thr Arg Gly Ile Ala Ala Asp Gly Ala
     300                 305                 310

 aat gcc ctt ctt cca gct aac aga gct atg gcc tat ctg aag att cag     1070
 Asn Ala Leu Leu Pro Ala Asn Arg Ala Met Ala Tyr Leu Lys Ile Gln
 315                 320                 325                 330

 aaa tat gaa gaa gct gaa aaa gac tgc aca caa gcc att tta tta gat     1118
 Lys Tyr Glu Glu Ala Glu Lys Asp Cys Thr Gln Ala Ile Leu Leu Asp
                 335                 340                 345

 ggc tca tat tct aaa gct ttt gcc aga aga gga act gca aga aca ttt     1166
 Gly Ser Tyr Ser Lys Ala Phe Ala Arg Arg Gly Thr Ala Arg Thr Phe
             350                 355                 360

 ttg gga aag cta aat gag gca aaa caa gat ttt gaa act gtt tta ctt     1214
 Leu Gly Lys Leu Asn Glu Ala Lys Gln Asp Phe Glu Thr Val Leu Leu
         365                 370                 375

 ctg gaa cct gga aat aag caa gca gta act gaa ctc tcc aaa att aaa     1262
 Leu Glu Pro Gly Asn Lys Gln Ala Val Thr Glu Leu Ser Lys Ile Lys
     380                 385                 390

 aag gaa tta att gag aaa gga cac tgg gat gat gtc ttt ctt gat tcc     1310
 Lys Glu Leu Ile Glu Lys Gly His Trp Asp Asp Val Phe Leu Asp Ser
 395                 400                 405                 410

 aca caa aga caa aat gtg gta aaa ccc att gat aat cca ccg cat cct     1358
 Thr Gln Arg Gln Asn Val Val Lys Pro Ile Asp Asn Pro Pro His Pro
                 415                 420                 425

 gga tca act aaa cca ctc aag aag gtt att att gaa gaa act ggt aat     1406
 Gly Ser Thr Lys Pro Leu Lys Lys Val Ile Ile Glu Glu Thr Gly Asn
             430                 435                 440

 ttg ata cag act att gat gtg cca gat agc act act gct gct gct cca     1454
 Leu Ile Gln Thr Ile Asp Val Pro Asp Ser Thr Thr Ala Ala Ala Pro
         445                 450                 455

 gag aat aat cct att aat cta gca aat gta ata gca gcc aca ggc acc     1502
 Glu Asn Asn Pro Ile Asn Leu Ala Asn Val Ile Ala Ala Thr Gly Thr
     460                 465                 470

 aca agt aag aag aat tca agc caa gat gac ctt ttt ccc aca agt gat     1550
 Thr Ser Lys Lys Asn Ser Ser Gln Asp Asp Leu Phe Pro Thr Ser Asp
 475                 480                 485                 490

 act cca aga gca aaa gta ttg aaa ata gaa gaa gtc agt gat act tca     1598
 Thr Pro Arg Ala Lys Val Leu Lys Ile Glu Glu Val Ser Asp Thr Ser
                 495                 500                 505

 tcc ctg caa cct caa gcc agt ttg aag cag gat gta tgt cag tct tac     1646
 Ser Leu Gln Pro Gln Ala Ser Leu Lys Gln Asp Val Cys Gln Ser Tyr
             510                 515                 520

 agc gag aaa atg ccc ata gag ata gaa caa aaa cct gct cag ttt gcc     1694
 Ser Glu Lys Met Pro Ile Glu Ile Glu Gln Lys Pro Ala Gln Phe Ala
         525                 530                 535

 aca act gtt ctt cct cca att cct gca aac tcg ttc cag ctc gaa tct     1742
 Thr Thr Val Leu Pro Pro Ile Pro Ala Asn Ser Phe Gln Leu Glu Ser
     540                 545                 550

 gat ttc aga caa ttg aaa agt tct cca gat atg ttg tat cag tat tta     1790
 Asp Phe Arg Gln Leu Lys Ser Ser Pro Asp Met Leu Tyr Gln Tyr Leu
 555                 560                 565                 570

 aag caa att gaa cca tct ttg tat cct aag ttg ttt cag aaa aat ctg     1838
 Lys Gln Ile Glu Pro Ser Leu Tyr Pro Lys Leu Phe Gln Lys Asn Leu
                 575                 580                 585

 gat cca gat gta ttc aac cag atc gtt aaa att ctg cat gac ttt tac     1886
 Asp Pro Asp Val Phe Asn Gln Ile Val Lys Ile Leu His Asp Phe Tyr
             590                 595                 600

 att gag aaa gaa aag cca tta ctc atc ttt gaa atc tta caa aga ctt     1934
 Ile Glu Lys Glu Lys Pro Leu Leu Ile Phe Glu Ile Leu Gln Arg Leu
         605                 610                 615

 tct gaa cta aaa agg ttt gat atg gca gtg atg ttt atg tca gaa aca     1982
 Ser Glu Leu Lys Arg Phe Asp Met Ala Val Met Phe Met Ser Glu Thr
     620                 625                 630

 gag aaa aag att gca cgt gca tta ttt aat cac ata gac aag tca gga     2030
 Glu Lys Lys Ile Ala Arg Ala Leu Phe Asn His Ile Asp Lys Ser Gly
 635                 640                 645                 650

 ttg aag gat agt tct gtc gaa gaa ctc aag aaa aga tac ggt ggt tga     2078
 Leu Lys Asp Ser Ser Val Glu Glu Leu Lys Lys Arg Tyr Gly Gly 
                 655                 660                 665

 tttccatttt tgctgaaata attgtttttg actttcatat gtaaattttt tctactgaaa   2138

 gtgttttgct ttttaagaaa atgaaattat atagcaggaa aggactatct ttgaacataa   2198

 gttaattaac tataaggtga attgtgattt aactagtgag aattgtattc aagtgaactc   2258

 tgtttttctg aaaataaaaa tataaacaat gagaaaaaaa aaaaa                   2303




      <210> 172
      <211> 767
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(750)

      <400> 172
 tttcgtcacg agtgaccacg gctagatagg ccgccggcca gatgtggcgg gggagagccg     60

 gggctttgct ccgggtgtgg gggttttggc cgacaggggt tcccagaagg agaccgctaa    120

 gctgcg   atg ctg cgt cgc agg cgg gaa gca att atc ccc gct gtt gga     168
          Met Leu Arg Arg Arg Arg Glu Ala Ile Ile Pro Ala Val Gly
            1               5                  10

 act gcg gcg gcc cat ggg gcc ccg ggc ggg agg aca ggt tct tct gcc      216
 Thr Ala Ala Ala His Gly Ala Pro Gly Gly Arg Thr Gly Ser Ser Ala
  15                  20                  25                  30

 cac agt gcc gag cgc tgc agg cac ctg acc cca ctc gag act act tca      264
 His Ser Ala Glu Arg Cys Arg His Leu Thr Pro Leu Glu Thr Thr Ser
                  35                  40                  45

 gcc tta tgg act ggt acg agc gac ggt ttc ggg aaa cgg gcc cgg gcg      312
 Ala Leu Trp Thr Gly Thr Ser Asp Gly Phe Gly Lys Arg Ala Arg Ala
              50                  55                  60

 aga gac acg tcg agc aac cgt tcc ttc aga gtt gat aca gcg aag ctc      360
 Arg Asp Thr Ser Ser Asn Arg Ser Phe Arg Val Asp Thr Ala Lys Leu
          65                  70                  75

 cag cac agg tac cag caa ctg cag cgt ctt gtc cac cca gat ttc ttc      408
 Gln His Arg Tyr Gln Gln Leu Gln Arg Leu Val His Pro Asp Phe Phe
      80                  85                  90

 agc cag agg tct cag act gaa aag gac ttc tca gag aag cat tcg acc      456
 Ser Gln Arg Ser Gln Thr Glu Lys Asp Phe Ser Glu Lys His Ser Thr
  95                 100                 105                 110

 ctg gtg aat gat gcc tat aag acc ctc ctg gcc ccc ctg agc aga gga      504
 Leu Val Asn Asp Ala Tyr Lys Thr Leu Leu Ala Pro Leu Ser Arg Gly
                 115                 120                 125

 ctg tac ctt cta aag ctc cat gga ata gag att cct gaa agg aca gat      552
 Leu Tyr Leu Leu Lys Leu His Gly Ile Glu Ile Pro Glu Arg Thr Asp
             130                 135                 140

 tat gaa atg gac agg caa ttc ctc ata gaa ata atg gaa atc aat gaa      600
 Tyr Glu Met Asp Arg Gln Phe Leu Ile Glu Ile Met Glu Ile Asn Glu
         145                 150                 155

 aaa ctc gca gaa gct gaa agt gaa gct gcc atg aaa gag att gaa tcc      648
 Lys Leu Ala Glu Ala Glu Ser Glu Ala Ala Met Lys Glu Ile Glu Ser
     160                 165                 170

 att gtc aaa gat gac ttt gaa gaa gcc aag gaa att ttg aca aag atg      696
 Ile Val Lys Asp Asp Phe Glu Glu Ala Lys Glu Ile Leu Thr Lys Met
 175                 180                 185                 190

 aga tac ttt tca aat ata gaa gaa aag atc aag tta aag aag att ccc      744
 Arg Tyr Phe Ser Asn Ile Glu Glu Lys Ile Lys Leu Lys Lys Ile Pro
                 195                 200                 205

 ctt taa ttgtggatag tttaaag                                           767
 Leu 






      <210> 173
      <211> 2730
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(1886)

      <400> 173
 tttcgtctgg ccgggaacgc acacaacgtc aaagcagtga ataagcgatt tctgcagttc     60

 ccgtagctgc cagcctgtgc agtcctctgt gatgcttggg gaccggctcc tcggtcacac    120

 cccagtcctg ctctgaaggt tgccgttttc caaacagaag g    atg gta gct aga     173
                                                  Met Val Ala Arg
                                                    1

 ggg gag ata gca aga ttc tgg agt ctg gaa agc ctt cac ttg gtt tct      221
 Gly Glu Ile Ala Arg Phe Trp Ser Leu Glu Ser Leu His Leu Val Ser
   5                  10                  15                  20

 tca gat gga ggt act gag ccc tct gcc tta gtg gat gac aac ggt agt      269
 Ser Asp Gly Gly Thr Glu Pro Ser Ala Leu Val Asp Asp Asn Gly Ser
                  25                  30                  35

 gag gag gac ttc agc tat gaa gac ctc tgc cag gcc agc cct cgg tac      317
 Glu Glu Asp Phe Ser Tyr Glu Asp Leu Cys Gln Ala Ser Pro Arg Tyr
              40                  45                  50

 ctg cag ccc ggc ggg gag cag ctg gcc atc aat gag ctg atc agt gat      365
 Leu Gln Pro Gly Gly Glu Gln Leu Ala Ile Asn Glu Leu Ile Ser Asp
          55                  60                  65

 ggc aac gtg gtc tgc gca gaa gcc ctg tgg gac cat gtg acc atg gat      413
 Gly Asn Val Val Cys Ala Glu Ala Leu Trp Asp His Val Thr Met Asp
      70                  75                  80

 gac cag gaa ctg ggc ttc aaa gcc ggg gat gtc atc cag gtt ctg gaa      461
 Asp Gln Glu Leu Gly Phe Lys Ala Gly Asp Val Ile Gln Val Leu Glu
  85                  90                  95                 100

 gcc tcc aac aag gac tgg tgg tgg ggc cgc agt gaa gat aag gaa gcc      509
 Ala Ser Asn Lys Asp Trp Trp Trp Gly Arg Ser Glu Asp Lys Glu Ala
                 105                 110                 115

 tgg ttc ccc gcg agc ttc gtc aga ttg cga gtg aat cag gaa gag ctg      557
 Trp Phe Pro Ala Ser Phe Val Arg Leu Arg Val Asn Gln Glu Glu Leu
             120                 125                 130

 tcg gaa aac tcc agc agc acc ccc agt gag gag cag gac gag gag gcc      605
 Ser Glu Asn Ser Ser Ser Thr Pro Ser Glu Glu Gln Asp Glu Glu Ala
         135                 140                 145

 agc cag agc cgc cac aga cac tgt gag aac aag cag cag atg cgg acc      653
 Ser Gln Ser Arg His Arg His Cys Glu Asn Lys Gln Gln Met Arg Thr
     150                 155                 160

 aac gtc atc cgg gag atc atg gac acc gag cgg gtg tac atc aaa cac      701
 Asn Val Ile Arg Glu Ile Met Asp Thr Glu Arg Val Tyr Ile Lys His
 165                 170                 175                 180

 ctc agg gac atc tgt gag ggc tat atc cga cag tgc cgc aag cac aca      749
 Leu Arg Asp Ile Cys Glu Gly Tyr Ile Arg Gln Cys Arg Lys His Thr
                 185                 190                 195

 gga atg ttc acc gtt gcg cag cta gcc act att ttt gga aac att gaa      797
 Gly Met Phe Thr Val Ala Gln Leu Ala Thr Ile Phe Gly Asn Ile Glu
             200                 205                 210

 gat att tac aaa ttc caa aga aag ttt ctg aaa gac ctt gag aaa cag      845
 Asp Ile Tyr Lys Phe Gln Arg Lys Phe Leu Lys Asp Leu Glu Lys Gln
         215                 220                 225

 tac aac aaa gag gaa cct cac tta agt gaa ata gga tct tgc ttt ctt      893
 Tyr Asn Lys Glu Glu Pro His Leu Ser Glu Ile Gly Ser Cys Phe Leu
     230                 235                 240

 caa aat caa gag ggc ttt gcc atc tat tcc gag tac tgc aac aac cac      941
 Gln Asn Gln Glu Gly Phe Ala Ile Tyr Ser Glu Tyr Cys Asn Asn His
 245                 250                 255                 260

 ccg ggc gcc tgc ctg gag ctc gcc aac ctc atg aag cag ggc aag tac      989
 Pro Gly Ala Cys Leu Glu Leu Ala Asn Leu Met Lys Gln Gly Lys Tyr
                 265                 270                 275

 aga cat ttc ttt gaa gcc tgc cgc ctg ctg cag cag atg att gac atc     1037
 Arg His Phe Phe Glu Ala Cys Arg Leu Leu Gln Gln Met Ile Asp Ile
             280                 285                 290

 gcc atc gac ggg ttc ctg ctc aca cca gtg cag aag atc tgc aaa tac     1085
 Ala Ile Asp Gly Phe Leu Leu Thr Pro Val Gln Lys Ile Cys Lys Tyr
         295                 300                 305

 ccg ctg cag ctg gcc gag ctg ctc aag tat acc aca cag gaa cac ggt     1133
 Pro Leu Gln Leu Ala Glu Leu Leu Lys Tyr Thr Thr Gln Glu His Gly
     310                 315                 320

 gat tac agc aac ata aag gca gca tat gag gcc atg aag aat gtg gcc     1181
 Asp Tyr Ser Asn Ile Lys Ala Ala Tyr Glu Ala Met Lys Asn Val Ala
 325                 330                 335                 340

 tgt ctg atc aac gag cgc aag cgc aag ctg gag agc atc gac aag ata     1229
 Cys Leu Ile Asn Glu Arg Lys Arg Lys Leu Glu Ser Ile Asp Lys Ile
                 345                 350                 355

 gct cgc tgg cag gtg tct atc gtg ggc tgg gag gga ctg gat atc tta     1277
 Ala Arg Trp Gln Val Ser Ile Val Gly Trp Glu Gly Leu Asp Ile Leu
             360                 365                 370

 gac cga agc tca gaa ttg att cat tct ggg gag ctg acc aaa atc act     1325
 Asp Arg Ser Ser Glu Leu Ile His Ser Gly Glu Leu Thr Lys Ile Thr
         375                 380                 385

 aag caa ggc aaa agc cag cag cgg acg ttc ttc ctg ttt gac cac cag     1373
 Lys Gln Gly Lys Ser Gln Gln Arg Thr Phe Phe Leu Phe Asp His Gln
     390                 395                 400

 ctg gtg tcc tgc aag aag gac ctg ctg cgc agg gac atg ctg tac tac     1421
 Leu Val Ser Cys Lys Lys Asp Leu Leu Arg Arg Asp Met Leu Tyr Tyr
 405                 410                 415                 420

 aag ggc cgg ctg gac atg gat gag atg gag ctt gtg gac ctg ggg gat     1469
 Lys Gly Arg Leu Asp Met Asp Glu Met Glu Leu Val Asp Leu Gly Asp
                 425                 430                 435

 ggg cgc gac aag gac tgc aac ctc agc gtg aaa aat gcc ttc aag ctc     1517
 Gly Arg Asp Lys Asp Cys Asn Leu Ser Val Lys Asn Ala Phe Lys Leu
             440                 445                 450

 gtc agt agg acc aca gac gag gtt tat ttg ttt tgt gcc aaa aaa caa     1565
 Val Ser Arg Thr Thr Asp Glu Val Tyr Leu Phe Cys Ala Lys Lys Gln
         455                 460                 465

 gaa gac aag gcg agg tgg ctg cag gcc tgt gca gat gaa agg agg cgg     1613
 Glu Asp Lys Ala Arg Trp Leu Gln Ala Cys Ala Asp Glu Arg Arg Arg
     470                 475                 480

 gtg caa gag gac aag gag atg gga atg gaa att tca gaa aac cag aag     1661
 Val Gln Glu Asp Lys Glu Met Gly Met Glu Ile Ser Glu Asn Gln Lys
 485                 490                 495                 500

 aaa ctt gcc atg tta aat gct caa aag gca gga cat gga aag tca aaa     1709
 Lys Leu Ala Met Leu Asn Ala Gln Lys Ala Gly His Gly Lys Ser Lys
                 505                 510                 515

 ggc tac aac agg tgc cct gtg gcc cca ccg cac cag ggc ctg cac ccc     1757
 Gly Tyr Asn Arg Cys Pro Val Ala Pro Pro His Gln Gly Leu His Pro
             520                 525                 530

 atc cac cag cgc cac atc act atg ccc aca agc gtc ccc cag cag cag     1805
 Ile His Gln Arg His Ile Thr Met Pro Thr Ser Val Pro Gln Gln Gln
         535                 540                 545

 gtc ttt ggc ctg gcg gaa ccc aag agg aag tcc tcg ctc ttc tgg cac     1853
 Val Phe Gly Leu Ala Glu Pro Lys Arg Lys Ser Ser Leu Phe Trp His
     550                 555                 560

 acc ttc aac agg ctc acc ccc ttc cgg aaa tga aaacagga ggctgtgctt     1904
 Thr Phe Asn Arg Leu Thr Pro Phe Arg Lys 
 565                 570

 ccatggagct gggtgtcaag agaagaactg tctttgtttc ttgtgtgctt caatccaggg   1964

 aaagtttctt ggacccagtg ataaaaactt ccttttaggg atcaatgaag gagagaaggt   2024

 cttggaatca ccttcagtct ttggagaccc agctgccttt gtggaaggga ggagacggtc   2084

 atgacacaaa gctttatcct acacagaaac acccgtgacc cactatgaga tggcccagat   2144

 gtgggacccg gtaccatgct ctaaagcgag tgattaggca gcagctgaag ccacccctgc   2204

 tgatgatgag caagtgcctg ctgcaggtcc aaacacagca tccagggctt tgcagttcct   2264

 aaggagtgat gaggttagag gatcacttct gcatttgatt ttcaaggatg ccgtcaagac   2324

 ggggttgaca caatgctgca cgtgtctggt cacacttaga aattgagctc ttactctctt   2384

 ctgtaatact gggggaccta cagctgccgt ggggctgacc acggtgttcc ctggcatcgt   2444

 ctgtgtccac acagatgcta actggtagtg caaatgtcat cctgcaaggt tcctcttcct   2504

 gcaagcaaag tggagagaaa gaagatgcat ctgtcacctt catcagggtc ctcagtgcag   2564

 agcaacttac gcatcctcaa gaatccactg cttttcaggc aaggagggag aaatcctgct   2624

 gcacactggc tttgtcccgg agtcggattc cctcctgcct gcacgccttc agtaactccg   2684

 agcagaaatc acatcttgcc cacatgctgt aacctaagaa actgct                  2730




      <210> 174
      <211> 1541
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (44)..(1231)

      <400> 174
 tttcgtgcgg gacttccgtg ttggcgggat tctgaacgct gcc  atg gct cag acc      55
                                                  Met Ala Gln Thr
                                                    1

 gtg cag aat gtt aca ttg tcg ctc act ctg ccc atc acg tgc cac att      103
 Val Gln Asn Val Thr Leu Ser Leu Thr Leu Pro Ile Thr Cys His Ile
   5                  10                  15                  20

 tgc ttg ggg aag gta cgt cag cct gtc ata tgc atc aac aac cat gta      151
 Cys Leu Gly Lys Val Arg Gln Pro Val Ile Cys Ile Asn Asn His Val
                  25                  30                  35

 ttt tgt tcg att tgt att gat ttg tgg ttg aag aat aat agc cag tgt      199
 Phe Cys Ser Ile Cys Ile Asp Leu Trp Leu Lys Asn Asn Ser Gln Cys
              40                  45                  50

 cca gct tgc aga gtc ccc atc act cct gaa aat cct tgc aaa gaa att      247
 Pro Ala Cys Arg Val Pro Ile Thr Pro Glu Asn Pro Cys Lys Glu Ile
          55                  60                  65

 ata gga gga aca agt gaa agt gaa cct atg cta agc cat acg gtc agg      295
 Ile Gly Gly Thr Ser Glu Ser Glu Pro Met Leu Ser His Thr Val Arg
      70                  75                  80

 aag cat ctt cgg aaa act aga ctt gaa tta cta cac aaa gaa tat gag      343
 Lys His Leu Arg Lys Thr Arg Leu Glu Leu Leu His Lys Glu Tyr Glu
  85                  90                  95                 100

 gac gaa ata gat tgt tta cag aaa gaa gta gaa gag ctt aag agt aaa      391
 Asp Glu Ile Asp Cys Leu Gln Lys Glu Val Glu Glu Leu Lys Ser Lys
                 105                 110                 115

 aat ctc agc ttg gag tca cag atc aaa act att ctg gat cct tta acc      439
 Asn Leu Ser Leu Glu Ser Gln Ile Lys Thr Ile Leu Asp Pro Leu Thr
             120                 125                 130

 ttg gtg cag ggc aac caa aat gaa gac aaa cat cta gtc aca gat aat      487
 Leu Val Gln Gly Asn Gln Asn Glu Asp Lys His Leu Val Thr Asp Asn
         135                 140                 145

 cca agt aaa att aac cca gaa act gta gca gag tgg aag aaa aaa ctc      535
 Pro Ser Lys Ile Asn Pro Glu Thr Val Ala Glu Trp Lys Lys Lys Leu
     150                 155                 160

 aga aca gct aat gaa atc tat gaa aaa gtg aaa gat gat gtg gat aag      583
 Arg Thr Ala Asn Glu Ile Tyr Glu Lys Val Lys Asp Asp Val Asp Lys
 165                 170                 175                 180

 cta aag gag gca aat aaa aaa ttg aaa ttg gaa aat ggt ggt ctg gtg      631
 Leu Lys Glu Ala Asn Lys Lys Leu Lys Leu Glu Asn Gly Gly Leu Val
                 185                 190                 195

 agg gag aat tta cga ctg aag gct gaa gtt gat aac aga tca cct caa      679
 Arg Glu Asn Leu Arg Leu Lys Ala Glu Val Asp Asn Arg Ser Pro Gln
             200                 205                 210

 aag ttt gga agg ttt gca gtt gct gct ctt cag tcc aaa gta gaa cag      727
 Lys Phe Gly Arg Phe Ala Val Ala Ala Leu Gln Ser Lys Val Glu Gln
         215                 220                 225

 tat gag cgt gaa acc aat cgc ctc aag aaa gcc ctg gaa cga agt gat      775
 Tyr Glu Arg Glu Thr Asn Arg Leu Lys Lys Ala Leu Glu Arg Ser Asp
     230                 235                 240

 aag tat ata gag gaa cta gaa tct caa gtt gca cag cta aaa aat tca      823
 Lys Tyr Ile Glu Glu Leu Glu Ser Gln Val Ala Gln Leu Lys Asn Ser
 245                 250                 255                 260

 agt gaa gag aaa gaa gct atg aat tcc att tgc cag aca gca ctt tct      871
 Ser Glu Glu Lys Glu Ala Met Asn Ser Ile Cys Gln Thr Ala Leu Ser
                 265                 270                 275

 gca gat ggc aaa ggg agc aaa ggc agt gag gag gat gtg gtg tca aag      919
 Ala Asp Gly Lys Gly Ser Lys Gly Ser Glu Glu Asp Val Val Ser Lys
             280                 285                 290

 aat caa ggc gat agt gcc aga aag cag cct ggc tca tcc acc tcc agt      967
 Asn Gln Gly Asp Ser Ala Arg Lys Gln Pro Gly Ser Ser Thr Ser Ser
         295                 300                 305

 tct tct cac cta gcg aag cct tcc agc agc aga ctg tgt gac acc agt     1015
 Ser Ser His Leu Ala Lys Pro Ser Ser Ser Arg Leu Cys Asp Thr Ser
     310                 315                 320

 tct gca agg cag gaa agt acc agc aaa gca gac ctt aac tgt tct aag     1063
 Ser Ala Arg Gln Glu Ser Thr Ser Lys Ala Asp Leu Asn Cys Ser Lys
 325                 330                 335                 340

 aac aaa gac cta tat caa gaa cag gta gaa gta atg tta gat gtg aca     1111
 Asn Lys Asp Leu Tyr Gln Glu Gln Val Glu Val Met Leu Asp Val Thr
                 345                 350                 355

 gat aca agt atg gat act tat ttg gaa aga gaa tgg ggg aat aaa cca     1159
 Asp Thr Ser Met Asp Thr Tyr Leu Glu Arg Glu Trp Gly Asn Lys Pro
             360                 365                 370

 agt gac tgt gta ccc tac aaa gat gaa gaa ctt tat gat ctt cca gct     1207
 Ser Asp Cys Val Pro Tyr Lys Asp Glu Glu Leu Tyr Asp Leu Pro Ala
         375                 380                 385

 cct tgt act cct ttg tcc ctt tag ttggccttca gctcaagtac tccaaaaaaa    1261
 Pro Cys Thr Pro Leu Ser Leu 
     390                 395

 atagaagaga gctttttgtg gtccaaaggc aagggaaggg ttcccaaaaa aaagagcaac   1321

 tttcaaaacc ccatttttca aaaaaaaaaa attggggggg gtttttggaa atggaatttt   1381

 ggggatttct tcaaaatggt ttctaataaa aagattcttt cagaaagatg aatattaagt   1441

 tggaaggtga aaaatgaaaa agaaaatcag aattgttttt ttttccccca aagaacaggg   1501

 aattttgggg aattgtttgg ttccacaaag ctaatgccca                         1541




      <210> 175
      <211> 1416
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (205)..(1305)

      <400> 175
 tggaatgctt tacaagatta ttttggtgat ttcatttgtc aacaaacaaa tccatgggag     60

 tctgttgtgc ataaattgaa aaagtcagaa acattatccc cttaattact gcttactgag    120

 ttttaaccat agtgtgctat gttagaaggc acacaattag aaaatacttg acttactcag    180

 ctatataatg attaacttga agac   atg ctt tta gct gta ata tca ttt ttc     231
                              Met Leu Leu Ala Val Ile Ser Phe Phe
                                1               5

 ttc att ttt aca atc tta aaa cta caa aat gct gtc ttt ctt tct ttc      279
 Phe Ile Phe Thr Ile Leu Lys Leu Gln Asn Ala Val Phe Leu Ser Phe
  10                  15                  20                  25

 aga aca ggt ggg att gtt cct cca gca gct caa cag ctt cac aga gaa      327
 Arg Thr Gly Gly Ile Val Pro Pro Ala Ala Gln Gln Leu His Arg Glu
                  30                  35                  40

 aat att caa cga ata gta caa gaa gct ctt tct gcc agt gga gtc tct      375
 Asn Ile Gln Arg Ile Val Gln Glu Ala Leu Ser Ala Ser Gly Val Ser
              45                  50                  55

 cca agt gac ctc tca gca att gca act acc ata aaa cca gga ctt gct      423
 Pro Ser Asp Leu Ser Ala Ile Ala Thr Thr Ile Lys Pro Gly Leu Ala
          60                  65                  70

 tta agc ctg gga gtg ggc tta tca ttt agc tta cag ctg gta gga cag      471
 Leu Ser Leu Gly Val Gly Leu Ser Phe Ser Leu Gln Leu Val Gly Gln
      75                  80                  85

 tta aaa aag cca ttc att ccc att cat cat atg gag gct cat gca ctt      519
 Leu Lys Lys Pro Phe Ile Pro Ile His His Met Glu Ala His Ala Leu
  90                  95                 100                 105

 act att agg ttg acc aat aaa gta gaa ttt cct ttt tta gtt ctt ttg      567
 Thr Ile Arg Leu Thr Asn Lys Val Glu Phe Pro Phe Leu Val Leu Leu
                 110                 115                 120

 att tct gga ggt cac tgt ctg ttg gca tta gtt caa gga gtt tca gat      615
 Ile Ser Gly Gly His Cys Leu Leu Ala Leu Val Gln Gly Val Ser Asp
             125                 130                 135

 ttt ctg ctt ctt gga aag tct ttg gac ata gca cca ggt gac atg ctt      663
 Phe Leu Leu Leu Gly Lys Ser Leu Asp Ile Ala Pro Gly Asp Met Leu
         140                 145                 150

 gac aag gtg gca aga aga ctt tct tta ata aaa cat cca gag tgc tcc      711
 Asp Lys Val Ala Arg Arg Leu Ser Leu Ile Lys His Pro Glu Cys Ser
     155                 160                 165

 acc atg agt ggt ggg aaa gcc ata gaa cat ttg gcc aaa caa gga aat      759
 Thr Met Ser Gly Gly Lys Ala Ile Glu His Leu Ala Lys Gln Gly Asn
 170                 175                 180                 185

 aga ttt cat ttt gac atc aaa cct ccc ttg cat cat gct aaa aat tgt      807
 Arg Phe His Phe Asp Ile Lys Pro Pro Leu His His Ala Lys Asn Cys
                 190                 195                 200

 gat ttt tct ttt act gga ctt caa cac gtt act gat aaa ata ata atg      855
 Asp Phe Ser Phe Thr Gly Leu Gln His Val Thr Asp Lys Ile Ile Met
             205                 210                 215

 aaa aag gaa aaa gag gaa ggt att gag aag ggg caa atc ctg tct tca      903
 Lys Lys Glu Lys Glu Glu Gly Ile Glu Lys Gly Gln Ile Leu Ser Ser
         220                 225                 230

 gca gca gac att gct gcc aca gta cag cac aca atg gca tgt cat ctt      951
 Ala Ala Asp Ile Ala Ala Thr Val Gln His Thr Met Ala Cys His Leu
     235                 240                 245

 gtg aaa aga aca cat cgg gct att ctg ttt tgt aag cag aga gac ttg      999
 Val Lys Arg Thr His Arg Ala Ile Leu Phe Cys Lys Gln Arg Asp Leu
 250                 255                 260                 265

 tta cct caa aat aat gca gta ctg gtt gca tct ggt ggt gtc gca agt     1047
 Leu Pro Gln Asn Asn Ala Val Leu Val Ala Ser Gly Gly Val Ala Ser
                 270                 275                 280

 aac ttc tat atc cgc aga gct ctg gaa att tta aca aac gca aca cag     1095
 Asn Phe Tyr Ile Arg Arg Ala Leu Glu Ile Leu Thr Asn Ala Thr Gln
             285                 290                 295

 tgc act ttg ttg tgt cct cct ccc aga cta tgc act gat aat ggc att     1143
 Cys Thr Leu Leu Cys Pro Pro Pro Arg Leu Cys Thr Asp Asn Gly Ile
         300                 305                 310

 atg att gca tgg aat ggt att gaa aga cta cgt gct ggc ttg ggc att     1191
 Met Ile Ala Trp Asn Gly Ile Glu Arg Leu Arg Ala Gly Leu Gly Ile
     315                 320                 325

 tta cat gac ata gaa ggc atc cgc tat gaa cca aaa tgt cct ctt gga     1239
 Leu His Asp Ile Glu Gly Ile Arg Tyr Glu Pro Lys Cys Pro Leu Gly
 330                 335                 340                 345

 gta gac ata tca aaa gaa gtt gga gaa gct tcc ata aaa gta cca caa     1287
 Val Asp Ile Ser Lys Glu Val Gly Glu Ala Ser Ile Lys Val Pro Gln
                 350                 355                 360

 tta aaa atg gag ata tga tttctg ctgttcaaaa aagtccctaa agggtctcac     1341
 Leu Lys Met Glu Ile 
             365

 tctctgacct cagctggagt acagtagcca gatcacaact cactgcaacc ctgacttcct   1401

 gaactcaaga aatct                                                    1416




      <210> 176
      <211> 2258
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (101)..(619)

      <400> 176
 gcacgagcca aagcgggaca ggtccagcgg ttgttctgtg tgaagtcgcg cggcttccac     60

 ccacgcagtg ttctaagtga aggccagaaa ctcgctcgcc  atg tcg gct gca gag     115
                                              Met Ser Ala Ala Glu
                                                1               5

 gcg ggg ggt gtt ttc cac aga gcc agg ggc agg acc ctg gcc gcg ttt      163
 Ala Gly Gly Val Phe His Arg Ala Arg Gly Arg Thr Leu Ala Ala Phe
                  10                  15                  20

 ccc gca gaa aag gaa agc gaa tgg aaa ggc cca ttc tac ttc atc ctg      211
 Pro Ala Glu Lys Glu Ser Glu Trp Lys Gly Pro Phe Tyr Phe Ile Leu
              25                  30                  35

 ggc gca gac cca cag ttt ggg ctg atc aag gcc tgg tcc act ggg gac      259
 Gly Ala Asp Pro Gln Phe Gly Leu Ile Lys Ala Trp Ser Thr Gly Asp
          40                  45                  50

 tgt gac aat ggc ggt gac gaa tgg gaa cag gag atc cgt cta act gag      307
 Cys Asp Asn Gly Gly Asp Glu Trp Glu Gln Glu Ile Arg Leu Thr Glu
      55                  60                  65

 caa gcc gtc cag gcc atc aac aag ctg aac ccc aaa ccc aaa ttc ttc      355
 Gln Ala Val Gln Ala Ile Asn Lys Leu Asn Pro Lys Pro Lys Phe Phe
  70                  75                  80                  85

 gtt ctg tgc ggc gac ctc atc cac gcc atg cca ggt gtc aga gtc gtg      403
 Val Leu Cys Gly Asp Leu Ile His Ala Met Pro Gly Val Arg Val Val
                  90                  95                 100

 ttc tca ggc cac tac cac agg aat gcc ggg ggt acc tac cag aac ctc      451
 Phe Ser Gly His Tyr His Arg Asn Ala Gly Gly Thr Tyr Gln Asn Leu
             105                 110                 115

 gac atg gtg gtg tca tct gcc att gga tgc cag ctg ggc aga gac ccc      499
 Asp Met Val Val Ser Ser Ala Ile Gly Cys Gln Leu Gly Arg Asp Pro
         120                 125                 130

 cac ggg ctc cga gtc gtg gtg gtc acc gcc gag aaa att gtt cac cga      547
 His Gly Leu Arg Val Val Val Val Thr Ala Glu Lys Ile Val His Arg
     135                 140                 145

 tac tac agt cta gat gag ctg agt gag aaa gga ata gaa gac gat ctc      595
 Tyr Tyr Ser Leu Asp Glu Leu Ser Glu Lys Gly Ile Glu Asp Asp Leu
 150                 155                 160                 165

 atg gat ttg atc aag aaa aaa tga cgctccttcc cgttcccgtt cacttttcac     649
 Met Asp Leu Ile Lys Lys Lys 
                 170

 ttgcactatt tttttatttt gccagaaaca gcagctgcac acaacctctt gctgaaatat    709

 aaaaatagcc caggcaggtt tgtgaattta tgtccttttg cataaatcag agagctgggg    769

 ccctgtcctg aattatattc aaaatagaac tgcatttcct ttaaaatgga gcgaatgatc    829

 ctggaaatca gtttttaaaa tattagacta tctctgcatg gatgtttgaa taaattctcc    889

 taatgctgtg tttctcaact ccacttttga attggattgt attctggtta gcatatggtc    949

 aaagtctgcc tatcgacctc aattccaatc tgacagccaa gtatgatctt tgataattcc   1009

 ttaaacaaac tacacctgat tgtattaaat tgtggtcacg attcccaaaa cgctaggcaa   1069

 aacaaagttc atctcctttc ctttccagcg gaacgaacag ctgtctgcct tgttgtgaga   1129

 gccatgcaga cttattttga caaggagcca agtaggcacc atttactgtt caattctgag   1189

 acttctgatg ataggaacag aatgcagttg atacagctcg gagcttaaat ttgccttcct   1249

 gggtgcctag aaaagtcacc tttgcacata aattggccat ttctgaaaat ctcctccaag   1309

 agactgaaac caaagctcta aaacgccgct tcttcagtct ctggggagca cgttgagttg   1369

 gttcacatcc acattctggc tgtgtagcca ctccacagat gggtggtctc ttgggatcag   1429

 aatgcccctc cactcatgag actcttcatt ttgtccactt tgacaggaaa agtgggaatg   1489

 tatgcagagc tctcaaaaga aacaaaaaag gccaaaacgg tgccttcagc cacatcctct   1549

 gaattggccc tgacttggac taaatgcact aatgcaaaat cccttgacaa aagcgcatag   1609

 gttatttcaa accagcattg ttttttatgt aacctgtttt accgcatctt ctcagcagct   1669

 tctgaccact gctcaatttt ctcctttaca gccattgttc tggtggacaa ataacctagg   1729

 tactccaaat cctggcagga aaaatataca gcattatgaa acagcactca gtaatcctaa   1789

 aatgatttcc aaagctggtt acacatgacc tgcaaagtct attaaattaa aagactttct   1849

 cattacagag tttagtcaac gtagcaaaac catgggaaat taaatggaaa gataattaaa   1909

 tatgtaaatt cataaggaac aaaagacgag aagttaatta tacaataggc tggtgacacc   1969

 agagttcatt gttatgtgcc acaagaaaat taaatttttt aaaaaactag aacgctcttc   2029

 ttttagtgtt ttgctgaaat cctgttttgt atttgtttct ttacaacagg tgtaggtata   2089

 ggaggtcaag aaaaggagtt cggtaaaggg catagctaat aacaaccaca cattgggcca   2149

 ggcgcagtgg cttacgcctg taatcccagc actttgggag gctgagacgg gcagatcacc   2209

 tgagatcagg agtttgagaa cagcctggcc aacatggtga aactccatt               2258




      <210> 177
      <211> 1453
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(1338)

      <400> 177
 gcgccgctgg ccgacggagg ggagcctgcc gatgccgagc gggtgctacg tcccgcggtc     60

 ggagccgcgt cttctcccgg ctccgccacc agccggggct cgggtggggg cccggggccc    120

 cggggc   atg gcc ctc cgg agt gcg cag ggc gac ggc ccc acc tcc ggc     168
          Met Ala Leu Arg Ser Ala Gln Gly Asp Gly Pro Thr Ser Gly
            1               5                  10

 cac tgg gac ggc ggc gcg gag aag gca gac ttt aac gcc aaa agg aaa      216
 His Trp Asp Gly Gly Ala Glu Lys Ala Asp Phe Asn Ala Lys Arg Lys
  15                  20                  25                  30

 aag aaa gtg gca gag ata cac cag gct ctg aac agt gat ccc act gat      264
 Lys Lys Val Ala Glu Ile His Gln Ala Leu Asn Ser Asp Pro Thr Asp
                  35                  40                  45

 gtg gct gcc ctt aga cgc atg gct atc agt gaa gga ggg ctc ctg act      312
 Val Ala Ala Leu Arg Arg Met Ala Ile Ser Glu Gly Gly Leu Leu Thr
              50                  55                  60

 gat gag atc aga cga aaa gtg tgg ccc aag ctc ctc aat gtc aat gcc      360
 Asp Glu Ile Arg Arg Lys Val Trp Pro Lys Leu Leu Asn Val Asn Ala
          65                  70                  75

 aat gac cca cct cct ata tca ggg aag aac cta cgg cag atg agc aag      408
 Asn Asp Pro Pro Pro Ile Ser Gly Lys Asn Leu Arg Gln Met Ser Lys
      80                  85                  90

 gac tac caa caa gtg ttg ctg gac gtc cgg cgg tca ttg cgg cgg ttc      456
 Asp Tyr Gln Gln Val Leu Leu Asp Val Arg Arg Ser Leu Arg Arg Phe
  95                 100                 105                 110

 cct cct ggc atg cca gag gaa cag aga gaa ggg ctc cag gaa gaa ctg      504
 Pro Pro Gly Met Pro Glu Glu Gln Arg Glu Gly Leu Gln Glu Glu Leu
                 115                 120                 125

 att gac atc atc ctc ctc atc ttg gag cgc aac cct cag ctg cac tac      552
 Ile Asp Ile Ile Leu Leu Ile Leu Glu Arg Asn Pro Gln Leu His Tyr
             130                 135                 140

 tac cag ggc tac cat gac att gtg gtc aca ttt ctg ctg gtg gta ggc      600
 Tyr Gln Gly Tyr His Asp Ile Val Val Thr Phe Leu Leu Val Val Gly
         145                 150                 155

 gag agg ctg gca aca tcc ctg gta gaa aaa tta tct acc cac cac ctc      648
 Glu Arg Leu Ala Thr Ser Leu Val Glu Lys Leu Ser Thr His His Leu
     160                 165                 170

 agg gat ttt atg gat cca aca atg gac aac acc aag cat ata tta aac      696
 Arg Asp Phe Met Asp Pro Thr Met Asp Asn Thr Lys His Ile Leu Asn
 175                 180                 185                 190

 tat ctg atg ccc atc att gac cag gtg aat cca gag ctc cat gac ttc      744
 Tyr Leu Met Pro Ile Ile Asp Gln Val Asn Pro Glu Leu His Asp Phe
                 195                 200                 205

 atg cag agt gct gag gta ggg acc atc ttt gcc ctc agc tgg ctc atc      792
 Met Gln Ser Ala Glu Val Gly Thr Ile Phe Ala Leu Ser Trp Leu Ile
             210                 215                 220

 acc tgg ttt ggg cat gtc ctg tct gac ttc agg cac gtc gtg cgg tta      840
 Thr Trp Phe Gly His Val Leu Ser Asp Phe Arg His Val Val Arg Leu
         225                 230                 235

 tat gac ttc ttc ctg gcc tgc cac cca ctg atg ccg att tac ttt gca      888
 Tyr Asp Phe Phe Leu Ala Cys His Pro Leu Met Pro Ile Tyr Phe Ala
     240                 245                 250

 gcc gtg att gtg ttg tat cgc gag cag gaa gtc ctg gac tgt gac tgt      936
 Ala Val Ile Val Leu Tyr Arg Glu Gln Glu Val Leu Asp Cys Asp Cys
 255                 260                 265                 270

 gac atg gcc tcg gtc cac cac ctg ttg tcc cag atc cct cag gac ttg      984
 Asp Met Ala Ser Val His His Leu Leu Ser Gln Ile Pro Gln Asp Leu
                 275                 280                 285

 ccc tat gag aca ctg atc agc aga gca gga gac ctt ttt gtt cag ttt     1032
 Pro Tyr Glu Thr Leu Ile Ser Arg Ala Gly Asp Leu Phe Val Gln Phe
             290                 295                 300

 ccc cca tcc gaa ctt gct cgg gag gcc gct gcc caa cag caa gct gag     1080
 Pro Pro Ser Glu Leu Ala Arg Glu Ala Ala Ala Gln Gln Gln Ala Glu
         305                 310                 315

 agg acg gca gcc tct act ttc aaa gac ttt gag ctg gca tca gcc cag     1128
 Arg Thr Ala Ala Ser Thr Phe Lys Asp Phe Glu Leu Ala Ser Ala Gln
     320                 325                 330

 cag agg cct gat atg gtg ctg cgg cag cgg ttt cgg gga ctt ctg cgg     1176
 Gln Arg Pro Asp Met Val Leu Arg Gln Arg Phe Arg Gly Leu Leu Arg
 335                 340                 345                 350

 cct gaa gat cga aca aaa gat gtc ctg acc aag cca agg acc aac cgc     1224
 Pro Glu Asp Arg Thr Lys Asp Val Leu Thr Lys Pro Arg Thr Asn Arg
                 355                 360                 365

 ttt gtg aaa ttg gca gtg atg ggg ctg aca gtg gca ctt gga gcg gct     1272
 Phe Val Lys Leu Ala Val Met Gly Leu Thr Val Ala Leu Gly Ala Ala
             370                 375                 380

 gca ctg gct gtg gtg aaa agt gcc ctg gaa tgg gcc cct aag ttt cag     1320
 Ala Leu Ala Val Val Lys Ser Ala Leu Glu Trp Ala Pro Lys Phe Gln
         385                 390                 395

 ctg cag ctg ttt ccc tga aagcca gagaagacct tcctcttaca tcacattaag     1374
 Leu Gln Leu Phe Pro 
     400

 gtctcaccct tccatggaag gattgggagg ggtggaattt cctttattaa aagggtttct   1434

 gtccaaaaaa aaaaaaaaa                                                1453




      <210> 178
      <211> 2465
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(927)

      <400> 178
 aactagataa gctgttacgc ctgcacgtac cggtccggaa ttcccgggtc gacgatttcg     60

 tgccgggccg cgccgccgct gccgccgccg cgcgcggatt ctgcttctca gaag  atg     117
                                                              Met
                                                                1

 cac tat tat aga tac tct aac gcc aag gtc agc tgc tgg tac aag tac      165
 His Tyr Tyr Arg Tyr Ser Asn Ala Lys Val Ser Cys Trp Tyr Lys Tyr
               5                  10                  15

 ctc ctt ttc agc tac aac atc atc ttc tgg ttg gct gga gtt gtc ttc      213
 Leu Leu Phe Ser Tyr Asn Ile Ile Phe Trp Leu Ala Gly Val Val Phe
          20                  25                  30

 ctt gga gtc ggg ctg tgg gca tgg agc gaa aag ggt gtg ctg tcc gac      261
 Leu Gly Val Gly Leu Trp Ala Trp Ser Glu Lys Gly Val Leu Ser Asp
      35                  40                  45

 ctc acc aaa gtg acc cgg atg cat gga atc gac cct gtg gtg ctg gtc      309
 Leu Thr Lys Val Thr Arg Met His Gly Ile Asp Pro Val Val Leu Val
  50                  55                  60                  65

 ctg atg gtg ggc gtg gtg atg ttc acc ctg ggg ttc gcc ggc tgc gtg      357
 Leu Met Val Gly Val Val Met Phe Thr Leu Gly Phe Ala Gly Cys Val
                  70                  75                  80

 ggg gct ctg cgg gag aat atc tgc ttg ctc aac ttt ttc tgt ggc acc      405
 Gly Ala Leu Arg Glu Asn Ile Cys Leu Leu Asn Phe Phe Cys Gly Thr
              85                  90                  95

 atc gtg ctc atc ttc ttc ctg gag ctg gct gtg gcc gtg ctg gcc ttc      453
 Ile Val Leu Ile Phe Phe Leu Glu Leu Ala Val Ala Val Leu Ala Phe
         100                 105                 110

 ctg ttc cag gac tgg gtg agg gac cgg ttc cgg gag ttc ttc gag agc      501
 Leu Phe Gln Asp Trp Val Arg Asp Arg Phe Arg Glu Phe Phe Glu Ser
     115                 120                 125

 aac atc aag tcc tac cgg gac gat atc gat ctg caa aac ctc atc gac      549
 Asn Ile Lys Ser Tyr Arg Asp Asp Ile Asp Leu Gln Asn Leu Ile Asp
 130                 135                 140                 145

 tcc ctt cag aaa gct aac cag tgc tgt ggc gca tat ggc cct gaa gac      597
 Ser Leu Gln Lys Ala Asn Gln Cys Cys Gly Ala Tyr Gly Pro Glu Asp
                 150                 155                 160

 tgg gac ctc aac gtc tac ttc aat tgc agc ggt gcc agc tac agc cga      645
 Trp Asp Leu Asn Val Tyr Phe Asn Cys Ser Gly Ala Ser Tyr Ser Arg
             165                 170                 175

 gag aag tgc ggg gtc ccc ttc tcc tgc tgc gtg cca gat cct gcg caa      693
 Glu Lys Cys Gly Val Pro Phe Ser Cys Cys Val Pro Asp Pro Ala Gln
         180                 185                 190

 aaa gtt gtg aac aca cag tgt gga tat gat gtc agg att cag ctg aag      741
 Lys Val Val Asn Thr Gln Cys Gly Tyr Asp Val Arg Ile Gln Leu Lys
     195                 200                 205

 agc aag tgg gat gag tcc atc ttc acg aaa ggc tgc atc cag gcg ctg      789
 Ser Lys Trp Asp Glu Ser Ile Phe Thr Lys Gly Cys Ile Gln Ala Leu
 210                 215                 220                 225

 gaa agc tgg ctc ccg cgg aac att tac att gtg gct ggc gtc ttc atc      837
 Glu Ser Trp Leu Pro Arg Asn Ile Tyr Ile Val Ala Gly Val Phe Ile
                 230                 235                 240

 gcc atc tcg ctg ttg cag ata ttt ggc atc ttc ctg gca agg acg ctg      885
 Ala Ile Ser Leu Leu Gln Ile Phe Gly Ile Phe Leu Ala Arg Thr Leu
             245                 250                 255

 atc tca gac atc gag gca gtg aag gcc ggc cat cac ttc tga ggagcag      934
 Ile Ser Asp Ile Glu Ala Val Lys Ala Gly His His Phe 
         260                 265                 270

 agttgaggga gccgagctga gccacgctgg gaggccagag cctttctctg ccatcagccc    994

 tacgtccaga gggagaggag ccgacacccc cagagccagt gccccatctt aagcatcagc   1054

 gtgacgtgac ctctctgttt ctgcttgctg gtgctgaaga ccaagggtcc cccttgttac   1114

 ctgcccaaac ttgtgactgc atccctctgg agtctaccca gagacagaga atgtgtcttt   1174

 atgtgggagt ggtgactctg aaagacagag agggctcctg tggctgccag gagggcttga   1234

 ctcagacccc ctgcagctca agcatgtctg caggacaccc tggtcccctc tccactggca   1294

 tccagacatc tgctttgggt catccacatc tgtgggtggg ccgtgggtag agggacccac   1354

 aggcgtggac agggcatctc tctccatcaa gcaaagcagc atgggggcct gcccctaatg   1414

 ggaggcggac gtggccccgc tgggcctctg agtgccagcg cagtctgctg ggacatgcac   1474

 atatcagggg ttgtttgcag gatcctcagc catgttcaag tgaagtaagc ctgagccagt   1534

 gcgtggactg gtgccacggg agtgccttgt ccactgtccc cctgtgtcca ccagctattc   1594

 tcctggcgcc ggaactgcct ctggtcttga tagcattaag ccctgatggc gccggtggcg   1654

 cggtgggcat ggttcttcac tgagagccgg ctctcctttt cttaaagtgt gtaaatagtt   1714

 tatttatagg ggtaagaatg ttctcacacc atttcacttc ctcttcctct cctccagcat   1774

 tctcctctga gcagccttag atagtgtcca tggctggagc cgaccctttg agtccccttg   1834

 agtgtcttaa gaaccagccc acaacagcct ctctttctcc tccacatact gcagcctccc   1894

 tccatgcatc ccacatacaa gcactccccc actccccagc gtggcctcac tgtcttctgg   1954

 tcttggtgct actgaaattg tcacccagaa tttgaatcct gaccctcccc actgcaagcc   2014

 cagggagccc cagcccaaga tggccagcct gaaactgttg gccagggctc ctcttgtggc   2074

 catgtaccca gggctggctg gcctgccatt tgcctctccc cggagacagc cgttcttctg   2134

 caaccacacc ccgtgcctag ccacaacccc aggctgcagc tgctcagaag ctccaggcat   2194

 tttgtttctg gtgaccgccc ctaatgggat atcggtgatc actggtccac ccttcctgtc   2254

 agggcttttc tggggctgct cttggaaatg aagtcttaag tactgaataa ctcccctggg   2314

 gatagctggg gcatttgtct agctgggcta ctttctaaca ctttgccata gctcagacca   2374

 cttctcatcg ttcagggatg gactgcaacc ttaatttact tgccggagtg tacattctag   2434

 tgtggtgtat actggtggct gttgatgatg a                                  2465




      <210> 179
      <211> 1145
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(722)

      <400> 179
 tgcagccctt gccttgagtc agtgcgccgc tctccagccc gcttgaacgc tccccgcagc     60

 caccgccacc cattgga   atg gcc aac agg gga cct gca tat ggc ctg agc     110
                      Met Ala Asn Arg Gly Pro Ala Tyr Gly Leu Ser
                        1               5                  10

 cgg gag gtg cag cag aag att gag aaa caa tat gat gca gat ctg gag      158
 Arg Glu Val Gln Gln Lys Ile Glu Lys Gln Tyr Asp Ala Asp Leu Glu
              15                  20                  25

 cag atc ctg atc cag tgg atc acc acc cag tgc cga aag gat gtg ggc      206
 Gln Ile Leu Ile Gln Trp Ile Thr Thr Gln Cys Arg Lys Asp Val Gly
          30                  35                  40

 cgg ccc cag cct gga cgc gag aac ttc cag aac tgg ctc aag gat ggc      254
 Arg Pro Gln Pro Gly Arg Glu Asn Phe Gln Asn Trp Leu Lys Asp Gly
      45                  50                  55

 acg gtg cta tgt gag ctc att aat gca ctg tac ccc gag ggg cag gcc      302
 Thr Val Leu Cys Glu Leu Ile Asn Ala Leu Tyr Pro Glu Gly Gln Ala
  60                  65                  70                  75

 cca gta aag aag atc cag gcc tcc acc atg gcc ttc aag cag atg gag      350
 Pro Val Lys Lys Ile Gln Ala Ser Thr Met Ala Phe Lys Gln Met Glu
                  80                  85                  90

 cag atc tct cag ttc ctg caa gca gct gag cgc tat ggc att aac acc      398
 Gln Ile Ser Gln Phe Leu Gln Ala Ala Glu Arg Tyr Gly Ile Asn Thr
              95                 100                 105

 act gac atc ttc caa act gtg gac ctc tgg gaa gga aag aac atg gcc      446
 Thr Asp Ile Phe Gln Thr Val Asp Leu Trp Glu Gly Lys Asn Met Ala
         110                 115                 120

 tgt gtg cag cgg acg ctg atg aat ctg ggt ggg ctg gca gta gcc cga      494
 Cys Val Gln Arg Thr Leu Met Asn Leu Gly Gly Leu Ala Val Ala Arg
     125                 130                 135

 gat gat ggg ctc ttc tct ggg gat ccc aac tgg ttc cct aag aaa tcc      542
 Asp Asp Gly Leu Phe Ser Gly Asp Pro Asn Trp Phe Pro Lys Lys Ser
 140                 145                 150                 155

 aag gag aat cct cgg aac ttc tcg gat aac cag ctg caa gag ggc aag      590
 Lys Glu Asn Pro Arg Asn Phe Ser Asp Asn Gln Leu Gln Glu Gly Lys
                 160                 165                 170

 aac gtg atc ggg tta cag atg ggc acc aac cgc ggg gcg tct cag gca      638
 Asn Val Ile Gly Leu Gln Met Gly Thr Asn Arg Gly Ala Ser Gln Ala
             175                 180                 185

 ggc atg act ggc tac ggg atg cca cgc cag atc ttc ctg att ccc acc      686
 Gly Met Thr Gly Tyr Gly Met Pro Arg Gln Ile Phe Leu Ile Pro Thr
         190                 195                 200

 cca ggc ctt gcc cct ggg cct ccc acg aat ggt taa tata tatgtagata      736
 Pro Gly Leu Ala Pro Gly Pro Pro Thr Asn Gly 
     205                 210

 tatattttaa gcagtgacct ttcccagtag agccccagag gctctcaggc tccttacggt    796

 ccagggtggg ggggtcacgc cctgggctgt tcgacctctg gaggtgcctg ctggggattc    856

 gactacccgc gatggttacc taataacatg cccattcccc agtaggcctg caaagcatga    916

 gaccaacttg ggcacttatt cactttatcc caggggaccc agtaatttat ggggggcgca    976

 aagagcccat cacccgagaa tagcaggagc gaataagtag catcatataa ccccagagac   1036

 ggtgataggt caaaagacat aggtagccac agaacaacac acgggaggga gacaacacaa   1096

 acagacgaac agcacacaaa gaaagaaaga caagcaaaaa aagagtaca               1145




      <210> 180
      <211> 1934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(1666)

      <400> 180
 cggacgcgtg ggcggagagg aggtggctcc agag    atg gca gtg agc gag agg      52
                                          Met Ala Val Ser Glu Arg
                                            1               5

 agg ggg ctc ggc cgc ggg agc ccc gcg gag tgg ggg cag cgg cta ctt      100
 Arg Gly Leu Gly Arg Gly Ser Pro Ala Glu Trp Gly Gln Arg Leu Leu
              10                  15                  20

 ctg gtg ctg ctg ttg ggt ggc tgc tcc ggg cgc atc cac cgg ctg gcg      148
 Leu Val Leu Leu Leu Gly Gly Cys Ser Gly Arg Ile His Arg Leu Ala
          25                  30                  35

 ctg acg ggg gag aag cga gcg gac atc cag ctg aac agc ttc ggt ttc      196
 Leu Thr Gly Glu Lys Arg Ala Asp Ile Gln Leu Asn Ser Phe Gly Phe
      40                  45                  50

 tac acc aat ggc tct ctg gag gtg gag ttg agc gtc ctg cgg ctg ggc      244
 Tyr Thr Asn Gly Ser Leu Glu Val Glu Leu Ser Val Leu Arg Leu Gly
  55                  60                  65                  70

 ctc cgg gag gca gaa gag aag tcc ctg ctg gtg ggg ttc agt ctc agc      292
 Leu Arg Glu Ala Glu Glu Lys Ser Leu Leu Val Gly Phe Ser Leu Ser
                  75                  80                  85

 cgg gtt cgg tct ggc aga gtt cgc tcc tat tca acc cgg gat ttc cag      340
 Arg Val Arg Ser Gly Arg Val Arg Ser Tyr Ser Thr Arg Asp Phe Gln
              90                  95                 100

 gac tgc cct ctc cag aaa aac agt agc agt ttc ctg gtc ctg ttc ctc      388
 Asp Cys Pro Leu Gln Lys Asn Ser Ser Ser Phe Leu Val Leu Phe Leu
         105                 110                 115

 atc aac acc aag gat ctg cag gtc cag gtg cgg aag tat gga gag cag      436
 Ile Asn Thr Lys Asp Leu Gln Val Gln Val Arg Lys Tyr Gly Glu Gln
     120                 125                 130

 aag acg ttg ttt atc ttt ccc ggg ctc ctc ccg gaa gca ccc tcc aaa      484
 Lys Thr Leu Phe Ile Phe Pro Gly Leu Leu Pro Glu Ala Pro Ser Lys
 135                 140                 145                 150

 cca ggg ctc ccg aag cca cag gcc aca gtc ccc cgc aag gtg gat ggc      532
 Pro Gly Leu Pro Lys Pro Gln Ala Thr Val Pro Arg Lys Val Asp Gly
                 155                 160                 165

 gga ggg acc tct gca gcc agc aag ccc aag tca aca ccc gca gtg att      580
 Gly Gly Thr Ser Ala Ala Ser Lys Pro Lys Ser Thr Pro Ala Val Ile
             170                 175                 180

 cag ggt cct agt ggg aag gac aag gac ctg gtg ttg ggc ctg agc cac      628
 Gln Gly Pro Ser Gly Lys Asp Lys Asp Leu Val Leu Gly Leu Ser His
         185                 190                 195

 ctc aac aac tcc tac aac ttc agt ttc cac gtg gtg atc ggc tct cag      676
 Leu Asn Asn Ser Tyr Asn Phe Ser Phe His Val Val Ile Gly Ser Gln
     200                 205                 210

 gcg gaa gaa ggc cag tac agc ctg aac ttc cac aac tgc aac aat tca      724
 Ala Glu Glu Gly Gln Tyr Ser Leu Asn Phe His Asn Cys Asn Asn Ser
 215                 220                 225                 230

 gtg cca gga aag gag cat cca ttc gac atc acg gtg atg atc cgg gag      772
 Val Pro Gly Lys Glu His Pro Phe Asp Ile Thr Val Met Ile Arg Glu
                 235                 240                 245

 aag aac ccc gat ggc ttc ctg tcg gca gcg gag atg ccc ctt ttc aag      820
 Lys Asn Pro Asp Gly Phe Leu Ser Ala Ala Glu Met Pro Leu Phe Lys
             250                 255                 260

 ctc tac atg gtc atg tcc gcc tgc ttc ctg gcc gct ggc atc ttc tgg      868
 Leu Tyr Met Val Met Ser Ala Cys Phe Leu Ala Ala Gly Ile Phe Trp
         265                 270                 275

 gtg tcc atc ctc tgc agg aac acg tac agc gtc ttc aag atc cac tgg      916
 Val Ser Ile Leu Cys Arg Asn Thr Tyr Ser Val Phe Lys Ile His Trp
     280                 285                 290

 ctc atg gcg gcc ttg gcc ttc acc aag agc atc tct ctc ctc ttc cac      964
 Leu Met Ala Ala Leu Ala Phe Thr Lys Ser Ile Ser Leu Leu Phe His
 295                 300                 305                 310

 agc atc aac tac tac ttc atc aac agc cag ggc cac ccc atc gaa ggc     1012
 Ser Ile Asn Tyr Tyr Phe Ile Asn Ser Gln Gly His Pro Ile Glu Gly
                 315                 320                 325

 ctt gcc gtc atg tac tac atc gca cac ctg ctg aag ggc gcc ctc ctc     1060
 Leu Ala Val Met Tyr Tyr Ile Ala His Leu Leu Lys Gly Ala Leu Leu
             330                 335                 340

 ttc atc acc atc gcc ctg att ggc tca ggc tgg gcc ttc atc aag tac     1108
 Phe Ile Thr Ile Ala Leu Ile Gly Ser Gly Trp Ala Phe Ile Lys Tyr
         345                 350                 355

 gtc ctg tcg gat aag gag aag aag gtc ttt ggg atc gtg atc ccc atg     1156
 Val Leu Ser Asp Lys Glu Lys Lys Val Phe Gly Ile Val Ile Pro Met
     360                 365                 370

 cag gtc ctg gcc aac gtg gcc tac atc atc atc gag tcc cgc gag gaa     1204
 Gln Val Leu Ala Asn Val Ala Tyr Ile Ile Ile Glu Ser Arg Glu Glu
 375                 380                 385                 390

 ggc gcc agc gac tac gtg ctg tgg aag gag att ttg ttc ctg gtg gac     1252
 Gly Ala Ser Asp Tyr Val Leu Trp Lys Glu Ile Leu Phe Leu Val Asp
                 395                 400                 405

 ctc atc tgc tgt ggt gcc atc ctg ttc ccc gta gtc tgg tcc atc cgg     1300
 Leu Ile Cys Cys Gly Ala Ile Leu Phe Pro Val Val Trp Ser Ile Arg
             410                 415                 420

 cat ctc cag gat gcg tct ggc aca gac ggg aag gtg gca gtg aac ctg     1348
 His Leu Gln Asp Ala Ser Gly Thr Asp Gly Lys Val Ala Val Asn Leu
         425                 430                 435

 gcc aag ctg aag ctg ttc cgg cat tac tat gtc atg gtc atc tgc tac     1396
 Ala Lys Leu Lys Leu Phe Arg His Tyr Tyr Val Met Val Ile Cys Tyr
     440                 445                 450

 gtc tac ttc acc cgc atc atc gcc atc ctg ctg cag gtg gct gtg ccc     1444
 Val Tyr Phe Thr Arg Ile Ile Ala Ile Leu Leu Gln Val Ala Val Pro
 455                 460                 465                 470

 ttt cag tgg cag tgg ctg tac cag ctc ttg gtg gag ggc tcc acc ctg     1492
 Phe Gln Trp Gln Trp Leu Tyr Gln Leu Leu Val Glu Gly Ser Thr Leu
                 475                 480                 485

 gcc ttc ttc gtg ctc acg ggc tac aag ttc cag ccc aca gga aac aac     1540
 Ala Phe Phe Val Leu Thr Gly Tyr Lys Phe Gln Pro Thr Gly Asn Asn
             490                 495                 500

 ccg tac ctg cag ctg ccc cag gag gac gag gag gat gtt cag atg gag     1588
 Pro Tyr Leu Gln Leu Pro Gln Glu Asp Glu Glu Asp Val Gln Met Glu
         505                 510                 515

 caa gta atg acg gac tct ggg ttc cgg gaa ggc ctc tcc aaa gtc aac     1636
 Gln Val Met Thr Asp Ser Gly Phe Arg Glu Gly Leu Ser Lys Val Asn
     520                 525                 530

 aaa aca gcc agc ggg cgg gaa ctg tta tga t cacctccaca tctcagacca     1687
 Lys Thr Ala Ser Gly Arg Glu Leu Leu 
 535                 540

 aagggtcgtc ctcccccagc atttctcact cctgcccttc ttccacagcg tatgtgggga   1747

 ggtggagggg gtccatgtgg accaggcgcc cagctccccg ggaccccggt tcccggacaa   1807

 gcccatttgg aagaagagtc ccttcctccc cccaaatatt gggcagccct gtccttaccc   1867

 cgggaccacc cctcccttcc agctatgtgt acaataatga ccaatctgtt tggctaaaaa   1927

 aaaaaaa                                                             1934




      <210> 181
      <211> 1098
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(970)

      <400> 181
 atggtcccgc tactggaccc atttcctacc tgggaaatgg agtcgaagct gactcaaaac     60

 gtaacggccc aattgtcctt gagacttcat tccccagcaa gctcagcgtg taacgtgcgc    120

 t    atg gag ccg aaa gtc gca gag ctg aag cag aag atc gag gac acg     166
      Met Glu Pro Lys Val Ala Glu Leu Lys Gln Lys Ile Glu Asp Thr
        1               5                  10                  15

 cta tgt cct ttt ggc ttc gag gtt tac ccc ttc cag gtg gca tgg tac      214
 Leu Cys Pro Phe Gly Phe Glu Val Tyr Pro Phe Gln Val Ala Trp Tyr
                  20                  25                  30

 aat gaa ctc ttg cct cca gcc ttc cac cta ccg ctg cca gga cct acc      262
 Asn Glu Leu Leu Pro Pro Ala Phe His Leu Pro Leu Pro Gly Pro Thr
              35                  40                  45

 ctg gcc ttc ctg gta ctc agc acg cct gcc atg ttt gac cgg gcc ctc      310
 Leu Ala Phe Leu Val Leu Ser Thr Pro Ala Met Phe Asp Arg Ala Leu
          50                  55                  60

 aag ccc ttc ttg cag agc tgc cac ctc cga atg ctg act gac cca gtg      358
 Lys Pro Phe Leu Gln Ser Cys His Leu Arg Met Leu Thr Asp Pro Val
      65                  70                  75

 gac cag tgt gtg gcc tac cat ctg ggc cgt gtt aga gag agc ctc cca      406
 Asp Gln Cys Val Ala Tyr His Leu Gly Arg Val Arg Glu Ser Leu Pro
  80                  85                  90                  95

 gag ctg cag ata gaa atc att gct gac tac gag gta cac ccc aac cga      454
 Glu Leu Gln Ile Glu Ile Ile Ala Asp Tyr Glu Val His Pro Asn Arg
                 100                 105                 110

 cgc ccc aag atc ctg gcc cag aca gca gcc cat gta gct ggg gct gct      502
 Arg Pro Lys Ile Leu Ala Gln Thr Ala Ala His Val Ala Gly Ala Ala
             115                 120                 125

 tac tac tac caa cga caa gat gtg gag gct gac cca tgg ggg aac cag      550
 Tyr Tyr Tyr Gln Arg Gln Asp Val Glu Ala Asp Pro Trp Gly Asn Gln
         130                 135                 140

 cgc ata tca ggt gtg tgc ata cac ccc cga ttt ggg ggc tgg ttt gcc      598
 Arg Ile Ser Gly Val Cys Ile His Pro Arg Phe Gly Gly Trp Phe Ala
     145                 150                 155

 atc cga ggg gta gtg ctg ctg cca ggg ata gag gtg cca gat ctg cca      646
 Ile Arg Gly Val Val Leu Leu Pro Gly Ile Glu Val Pro Asp Leu Pro
 160                 165                 170                 175

 ccc aga aaa cct cat gac tgt gta cct aca aga gct gac cgt atc gcc      694
 Pro Arg Lys Pro His Asp Cys Val Pro Thr Arg Ala Asp Arg Ile Ala
                 180                 185                 190

 cta ctc gaa ggc ttc aat ttc cac tgg cgt gat tgg act tac cgg gat      742
 Leu Leu Glu Gly Phe Asn Phe His Trp Arg Asp Trp Thr Tyr Arg Asp
             195                 200                 205

 gct gtg aca ccc cag gag cgc tac tca gaa gag cag aag gcc tac ttc      790
 Ala Val Thr Pro Gln Glu Arg Tyr Ser Glu Glu Gln Lys Ala Tyr Phe
         210                 215                 220

 tcc act cca cct gcc caa cga ttg gcc cta ttg ggc ttg gct cag ccc      838
 Ser Thr Pro Pro Ala Gln Arg Leu Ala Leu Leu Gly Leu Ala Gln Pro
     225                 230                 235

 tca gag aag cct agt tct ccc tcc ccg gac ctt ccc ttt acc aca ccc      886
 Ser Glu Lys Pro Ser Ser Pro Ser Pro Asp Leu Pro Phe Thr Thr Pro
 240                 245                 250                 255

 gcc ccc aag aag cct ggg aat ccc agc aga gcc cgg agc tgg ctc agc      934
 Ala Pro Lys Lys Pro Gly Asn Pro Ser Arg Ala Arg Ser Trp Leu Ser
                 260                 265                 270

 ccc agg gtc tca cca cct gca tcc cct ggc cct tga tttt ctcccatgtg      984
 Pro Arg Val Ser Pro Pro Ala Ser Pro Gly Pro 
             275                 280

 gaccctgatt tatggtggta cttgctagga cttaattgtt cattcaaaaa aaggccaatc   1044

 tagagacctt taattatgtg gtcccagctt atctgccgct agtgctggcc aatg         1098




      <210> 182
      <211> 973
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (231)..(749)

      <400> 182
 tgtaatagtc taatgctcca cttaaagata cagaatgcag aatggatacg aatccaccaa     60

 cctaatatct gctaacacat atggactcac ataagttgag ggtaaagggg tgaaaaaaga    120

 tattccatgc aaatactaac cctaagcgag cagaaatagc tattcttata tcagacaaaa    180

 cagactttaa agcaacaata gtcgaaaaag acaaaaaggg acattacata   atg ata     236
                                                          Met Ile
                                                            1

 aaa gga tca gtc caa cag gaa aat atc aca atc cta aat ata tat gca      284
 Lys Gly Ser Val Gln Gln Glu Asn Ile Thr Ile Leu Asn Ile Tyr Ala
           5                  10                  15

 cct agc acg gga gct ccc aaa ttt ata aaa caa tta gta ctc aac gta      332
 Pro Ser Thr Gly Ala Pro Lys Phe Ile Lys Gln Leu Val Leu Asn Val
      20                  25                  30

 aga aat gag ata cac agc tac aca gta aca gcg ggg act tca aca cta      380
 Arg Asn Glu Ile His Ser Tyr Thr Val Thr Ala Gly Thr Ser Thr Leu
  35                  40                  45                  50

 gac agg tca tca aga cag aaa ggc aac aaa gaa aca atg gac tta cac      428
 Asp Arg Ser Ser Arg Gln Lys Gly Asn Lys Glu Thr Met Asp Leu His
                  55                  60                  65

 tat acc cta gaa caa atg gac tta aca cat att tac aga aca ttc tac      476
 Tyr Thr Leu Glu Gln Met Asp Leu Thr His Ile Tyr Arg Thr Phe Tyr
              70                  75                  80

 cca aca act gca gaa tat ata ttc tat tca tca gca cat gga aca ttc      524
 Pro Thr Thr Ala Glu Tyr Ile Phe Tyr Ser Ser Ala His Gly Thr Phe
          85                  90                  95

 tcc aag ata gac cag atg ata ggc cac aaa aca agt ctc agt aaa ctt      572
 Ser Lys Ile Asp Gln Met Ile Gly His Lys Thr Ser Leu Ser Lys Leu
     100                 105                 110

 aag aaa atc gaa att ata tca agc act ctc tca gat cac agt gga ata      620
 Lys Lys Ile Glu Ile Ile Ser Ser Thr Leu Ser Asp His Ser Gly Ile
 115                 120                 125                 130

 aaa ttg gaa atc aac tcc aaa aga aac cct cga aac cat gca aat aca      668
 Lys Leu Glu Ile Asn Ser Lys Arg Asn Pro Arg Asn His Ala Asn Thr
                 135                 140                 145

 tgg aaa tta aat aac ctg ttc ctg aat aat cgt tgg gtc aac aac gaa      716
 Trp Lys Leu Asn Asn Leu Phe Leu Asn Asn Arg Trp Val Asn Asn Glu
             150                 155                 160

 atc aag atg gaa att tta aaa ttc ttt gac tga acgataat agtgacacaa      767
 Ile Lys Met Glu Ile Leu Lys Phe Phe Asp 
         165                 170

 cctatcaaaa cctctgggat acagcaaagg cagtgctaag aggaaagttc atagcctaca    827

 tcaaaaagac tgaaagagca caaactgaca ctctaaggtc acacctcaag gaactagaga    887

 agcaagaaca aaccaaaccc aaacccagca gaagaaagga aataacaaag atcagaccag    947

 aactaaatga aattgaaaaa aaaaaa                                         973




      <210> 183
      <211> 765
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(510)

      <400> 183
 gggctcgctg ttgccctgaa ggcaggcgag ccagctgccc aggaaaggtg gaaagtggta     60

 gaagctgacc cctgagccct ggcaggtctt taagtgcgtt tgtgcagccg atttcaaggc    120

 taagagagaa agactgcctc tgatccctga aggaaaccgg gaaaaaacct cacc  atg     177
                                                              Met
                                                                1

 gaa aat gcc ccc agg gaa aac aaa gtt ggg gaa aag gcc cca ggg caa      225
 Glu Asn Ala Pro Arg Glu Asn Lys Val Gly Glu Lys Ala Pro Gly Gln
               5                  10                  15

 aat gaa ccc ccc gtt tta gga ggg ggg aaa tac cag gac cct gga gga      273
 Asn Glu Pro Pro Val Leu Gly Gly Gly Lys Tyr Gln Asp Pro Gly Gly
          20                  25                  30

 aat gtt aaa ggg gtt ggg cct ccc cct gcc ccg gtt ttt gaa aag gat      321
 Asn Val Lys Gly Val Gly Pro Pro Pro Ala Pro Val Phe Glu Lys Asp
      35                  40                  45

 ggc ccc aat agg ctt gtc aat aac ttt gat atg ata aag gga aat gga      369
 Gly Pro Asn Arg Leu Val Asn Asn Phe Asp Met Ile Lys Gly Asn Gly
  50                  55                  60                  65

 aat gat ttg gac cgg ttc ttg ggg gaa atg aaa aac cta agg ggg aaa      417
 Asn Asp Leu Asp Arg Phe Leu Gly Glu Met Lys Asn Leu Arg Gly Lys
                  70                  75                  80

 ttt agg gaa ctt cac ctg agg atc agt ctg ccc att ctt ata ggc gac      465
 Phe Arg Glu Leu His Leu Arg Ile Ser Leu Pro Ile Leu Ile Gly Asp
              85                  90                  95

 cct cct cac cat gat cat cat gat gag ttt tgc ctt atg cct tga atc      513
 Pro Pro His His Asp His His Asp Glu Phe Cys Leu Met Pro 
         100                 105                 110

 ttgaggttaa taatcataaa atccctgctt tctagattcg catttttcct ggtgtacctt    573

 taatgagaac cttttggcat tcttctgcaa ttttctgatt ggagattgca ttgtgaccta    633

 gcctgtaagt ttttctgtca caagaggact ttcatcatct ttcatggaaa gacgttcatt    693

 gcatactgta cagctagtaa agcagtttaa gagggggcta cggtcggcta cgctggggca    753

 catctggctc cc                                                        765




      <210> 184
      <211> 3049
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(3002)

      <400> 184
 tgggtgcatg cgctcgcatc    atg gcg gct gag tgg gct tct cgt ttc tgg      50
                          Met Ala Ala Glu Trp Ala Ser Arg Phe Trp
                            1               5                  10

 ctt tgg gct acg ctg ctg att cct gcg gcc gcg gtc tac gaa gac caa       98
 Leu Trp Ala Thr Leu Leu Ile Pro Ala Ala Ala Val Tyr Glu Asp Gln
                  15                  20                  25

 gtg ggc aag ttt gat tgg aga cag caa tat gtt ggg aag gtc aag ttt      146
 Val Gly Lys Phe Asp Trp Arg Gln Gln Tyr Val Gly Lys Val Lys Phe
              30                  35                  40

 gcc tcc ttg gaa ttt tcc cct gga tcc aag aag ttg gtt gta gcc aca      194
 Ala Ser Leu Glu Phe Ser Pro Gly Ser Lys Lys Leu Val Val Ala Thr
          45                  50                  55

 gag aag aat gtg att gca gca tta aat tcc cga act ggg gag atc ttg      242
 Glu Lys Asn Val Ile Ala Ala Leu Asn Ser Arg Thr Gly Glu Ile Leu
      60                  65                  70

 tgg cgc cat gtt gac aag ggc acg gca gaa ggg gct gtg gat gcc atg      290
 Trp Arg His Val Asp Lys Gly Thr Ala Glu Gly Ala Val Asp Ala Met
  75                  80                  85                  90

 ctg ctg cac gga cag gat gtg atc act gtg tcc aat gga ggc cga atc      338
 Leu Leu His Gly Gln Asp Val Ile Thr Val Ser Asn Gly Gly Arg Ile
                  95                 100                 105

 atg cgt tcc tgg gag act aac atc ggg ggc ctg aac tgg gag ata acc      386
 Met Arg Ser Trp Glu Thr Asn Ile Gly Gly Leu Asn Trp Glu Ile Thr
             110                 115                 120

 ctg gac agt ggc agt ttc cag gca ctt ggg ctg gtt ggc ctg cag gag      434
 Leu Asp Ser Gly Ser Phe Gln Ala Leu Gly Leu Val Gly Leu Gln Glu
         125                 130                 135

 tct gta agg tac atc gca gtc ctg aag aag act aca ctt gcc ctc cat      482
 Ser Val Arg Tyr Ile Ala Val Leu Lys Lys Thr Thr Leu Ala Leu His
     140                 145                 150

 cac ctc tcc agt ggg cac ctc aag tgg gtg gaa cat ctc cca gaa agt      530
 His Leu Ser Ser Gly His Leu Lys Trp Val Glu His Leu Pro Glu Ser
 155                 160                 165                 170

 gac agc atc cac tac cag atg gtg tat tct tac ggc tct ggg gtg gtg      578
 Asp Ser Ile His Tyr Gln Met Val Tyr Ser Tyr Gly Ser Gly Val Val
                 175                 180                 185

 tgg gcc ctc gga gtt gtt ccc ttc agc cat gtg aac att gtc aag ttt      626
 Trp Ala Leu Gly Val Val Pro Phe Ser His Val Asn Ile Val Lys Phe
             190                 195                 200

 aat gtg gaa gat gga gag att gtt cag cag gtt agg gtt tca act ccg      674
 Asn Val Glu Asp Gly Glu Ile Val Gln Gln Val Arg Val Ser Thr Pro
         205                 210                 215

 tgg ctg cag cac ctg tct gga gcc tgt ggt gtg gtg gat gag gct gtc      722
 Trp Leu Gln His Leu Ser Gly Ala Cys Gly Val Val Asp Glu Ala Val
     220                 225                 230

 ctg gtg tgt cct gac ccg agc tca cgt tcc ctc caa act ttg gct ctg      770
 Leu Val Cys Pro Asp Pro Ser Ser Arg Ser Leu Gln Thr Leu Ala Leu
 235                 240                 245                 250

 gag acg gaa tgg gag ttg aga cag atc cca ctg cag tct ctc gac tta      818
 Glu Thr Glu Trp Glu Leu Arg Gln Ile Pro Leu Gln Ser Leu Asp Leu
                 255                 260                 265

 gaa ttt gga agt gga ttc caa ccc cgg gtc ctg cct acc cag ccc aac      866
 Glu Phe Gly Ser Gly Phe Gln Pro Arg Val Leu Pro Thr Gln Pro Asn
             270                 275                 280

 cca gtg gac gct tcc cgg gcc cag ttc ttc ctg cac ttg tcc cca agc      914
 Pro Val Asp Ala Ser Arg Ala Gln Phe Phe Leu His Leu Ser Pro Ser
         285                 290                 295

 cac tat gct ctg ctg cag tac cat tat gga acg ctg agt ttg ctt aaa      962
 His Tyr Ala Leu Leu Gln Tyr His Tyr Gly Thr Leu Ser Leu Leu Lys
     300                 305                 310

 aac ttc cca cag act gcc cta gtg agc ttt gcc acc act ggg gag aag     1010
 Asn Phe Pro Gln Thr Ala Leu Val Ser Phe Ala Thr Thr Gly Glu Lys
 315                 320                 325                 330

 acg gtg gct gca gtc atg gcc tgt cgg aat gaa gtg cag aaa agt agc     1058
 Thr Val Ala Ala Val Met Ala Cys Arg Asn Glu Val Gln Lys Ser Ser
                 335                 340                 345

 agt tct gaa gat ggg tca atg ggg agc ttt tcg gag aag tct agt tca     1106
 Ser Ser Glu Asp Gly Ser Met Gly Ser Phe Ser Glu Lys Ser Ser Ser
             350                 355                 360

 aag gac tct ctg gct tgc ttc aat cag acc tac acc att aac cta tac     1154
 Lys Asp Ser Leu Ala Cys Phe Asn Gln Thr Tyr Thr Ile Asn Leu Tyr
         365                 370                 375

 ctc gtg gag aca ggt cgg cgg ctg ctg gac acc acg ata aca ttt agc     1202
 Leu Val Glu Thr Gly Arg Arg Leu Leu Asp Thr Thr Ile Thr Phe Ser
     380                 385                 390

 ctg gaa cag agc ggc act cgg cct gag cgg ctg tat atc cag gtg ttc     1250
 Leu Glu Gln Ser Gly Thr Arg Pro Glu Arg Leu Tyr Ile Gln Val Phe
 395                 400                 405                 410

 ttg aag aag gat gac tca gtg ggc tac cgg gct ttg gtg cag aca gag     1298
 Leu Lys Lys Asp Asp Ser Val Gly Tyr Arg Ala Leu Val Gln Thr Glu
                 415                 420                 425

 gat cat ctg cta ctt ttc ctg cag cag ttg gca ggg aag gtg gtg ctg     1346
 Asp His Leu Leu Leu Phe Leu Gln Gln Leu Ala Gly Lys Val Val Leu
             430                 435                 440

 tgg agc cgt gag gag tcc ctg gca gaa gtg gtg tgc cta gag atg gtg     1394
 Trp Ser Arg Glu Glu Ser Leu Ala Glu Val Val Cys Leu Glu Met Val
         445                 450                 455

 gac ctc ccc ctg act ggg gca cag gcc gag ctg gaa gga gaa ttt ggc     1442
 Asp Leu Pro Leu Thr Gly Ala Gln Ala Glu Leu Glu Gly Glu Phe Gly
     460                 465                 470

 aaa aag gca gat ggc ttg ctg ggg atg ttc ctg aaa cgc ctc tcg tct     1490
 Lys Lys Ala Asp Gly Leu Leu Gly Met Phe Leu Lys Arg Leu Ser Ser
 475                 480                 485                 490

 cag ctt atc ctg ctg caa gca tgg act tcc cac ctc tgg aaa atg ttt     1538
 Gln Leu Ile Leu Leu Gln Ala Trp Thr Ser His Leu Trp Lys Met Phe
                 495                 500                 505

 tat gat gct cgg aag ccc cgg agt cag att aag aat gag atc aac att     1586
 Tyr Asp Ala Arg Lys Pro Arg Ser Gln Ile Lys Asn Glu Ile Asn Ile
             510                 515                 520

 gac acc ctg gcc aga gat gaa ttc aac ctc cag aag atg atg gtg atg     1634
 Asp Thr Leu Ala Arg Asp Glu Phe Asn Leu Gln Lys Met Met Val Met
         525                 530                 535

 gta aca gcc tca ggc aag ctt ttt ggc att gag agc agc tct ggc acc     1682
 Val Thr Ala Ser Gly Lys Leu Phe Gly Ile Glu Ser Ser Ser Gly Thr
     540                 545                 550

 atc ctg tgg aaa cag tat cta ccc aat gtc aag cca gac tcc tcc ttt     1730
 Ile Leu Trp Lys Gln Tyr Leu Pro Asn Val Lys Pro Asp Ser Ser Phe
 555                 560                 565                 570

 aaa ctg atg gtc cag aga act act gct cat ttc ccc cat ccc cca cag     1778
 Lys Leu Met Val Gln Arg Thr Thr Ala His Phe Pro His Pro Pro Gln
                 575                 580                 585

 tgc acc ctg ctg gtg aag gac aag gag tcg gga atg agt tct ctg tat     1826
 Cys Thr Leu Leu Val Lys Asp Lys Glu Ser Gly Met Ser Ser Leu Tyr
             590                 595                 600

 gtc ttc aat ccc att ttt ggg aag tgg agt cag gta gct ccc cca gtg     1874
 Val Phe Asn Pro Ile Phe Gly Lys Trp Ser Gln Val Ala Pro Pro Val
         605                 610                 615

 ctg aag cgc ccc atc ttg cag tcc ttg ctt ctc cca gtc atg gat caa     1922
 Leu Lys Arg Pro Ile Leu Gln Ser Leu Leu Leu Pro Val Met Asp Gln
     620                 625                 630

 gac tac gcc aag gtg ttg ctg ttg ata gat gat gaa tac aag gtc aca     1970
 Asp Tyr Ala Lys Val Leu Leu Leu Ile Asp Asp Glu Tyr Lys Val Thr
 635                 640                 645                 650

 gct ttt cca gcc act cgg aat gtc ttg cga cag cta cat gag ctt gcc     2018
 Ala Phe Pro Ala Thr Arg Asn Val Leu Arg Gln Leu His Glu Leu Ala
                 655                 660                 665

 cct tcc atc ttc ttc tat ttg gtg gat gca gag cag gga cgg ctg tgt     2066
 Pro Ser Ile Phe Phe Tyr Leu Val Asp Ala Glu Gln Gly Arg Leu Cys
             670                 675                 680

 gga tat cgg ctt cga aag gat ctc acc act gag ctg agt tgg gag ctg     2114
 Gly Tyr Arg Leu Arg Lys Asp Leu Thr Thr Glu Leu Ser Trp Glu Leu
         685                 690                 695

 acc att ccc cca gaa gta cag cgg atc gtc aag gtg aag ggg aaa cgc     2162
 Thr Ile Pro Pro Glu Val Gln Arg Ile Val Lys Val Lys Gly Lys Arg
     700                 705                 710

 agc agt gag cac gtt cat tcc cag ggc cgt gtg atg ggg gac cgc agt     2210
 Ser Ser Glu His Val His Ser Gln Gly Arg Val Met Gly Asp Arg Ser
 715                 720                 725                 730

 gtg ctc tac aag agc ctg aac ccc aac ctg ctg gcc gtg gtg aca gag     2258
 Val Leu Tyr Lys Ser Leu Asn Pro Asn Leu Leu Ala Val Val Thr Glu
                 735                 740                 745

 agc aca gac gcg cac cat gag cgc acc ttt att ggc atc ttc ctc att     2306
 Ser Thr Asp Ala His His Glu Arg Thr Phe Ile Gly Ile Phe Leu Ile
             750                 755                 760

 gat ggc gtc act ggg cgt atc att cac tcc tct gtg cag aag aaa gcc     2354
 Asp Gly Val Thr Gly Arg Ile Ile His Ser Ser Val Gln Lys Lys Ala
         765                 770                 775

 aaa ggc cct gtc cat atc gtg cat tca gag aac tgg gtg gtg tac cag     2402
 Lys Gly Pro Val His Ile Val His Ser Glu Asn Trp Val Val Tyr Gln
     780                 785                 790

 tac tgg aac acc aag gct cgg cgc aac gag ttt acc gta ctg gag ctc     2450
 Tyr Trp Asn Thr Lys Ala Arg Arg Asn Glu Phe Thr Val Leu Glu Leu
 795                 800                 805                 810

 tat gag ggc act gag caa tac aac gcc acc gcc ttc agc tcc ctg gac     2498
 Tyr Glu Gly Thr Glu Gln Tyr Asn Ala Thr Ala Phe Ser Ser Leu Asp
                 815                 820                 825

 cgc ccc cag ctg ccc cag gtc ctc cag cag tcc tat atc ttc ccg tcc     2546
 Arg Pro Gln Leu Pro Gln Val Leu Gln Gln Ser Tyr Ile Phe Pro Ser
             830                 835                 840

 tcc atc agt gcc atg gag gcc acc atc acc gaa cgg ggc atc acc agc     2594
 Ser Ile Ser Ala Met Glu Ala Thr Ile Thr Glu Arg Gly Ile Thr Ser
         845                 850                 855

 cga cac ctg ctg att gga cta cct tct gga gca att ctt tcc ctt cct     2642
 Arg His Leu Leu Ile Gly Leu Pro Ser Gly Ala Ile Leu Ser Leu Pro
     860                 865                 870

 aag gct ttg ctg gat ccc cgc cgc ccc gag atc cca aca gaa caa agc     2690
 Lys Ala Leu Leu Asp Pro Arg Arg Pro Glu Ile Pro Thr Glu Gln Ser
 875                 880                 885                 890

 aga gag gag aac tta atc ccg tat tct cca gat gta cag ata cac gca     2738
 Arg Glu Glu Asn Leu Ile Pro Tyr Ser Pro Asp Val Gln Ile His Ala
                 895                 900                 905

 gag cga ttc atc aac tat aac cag aca gtt tct cga atg cga ggt atc     2786
 Glu Arg Phe Ile Asn Tyr Asn Gln Thr Val Ser Arg Met Arg Gly Ile
             910                 915                 920

 tac aca gct ccc tcg ggt ctg gag tcc act tgt ttg gtt gtg gcc tat     2834
 Tyr Thr Ala Pro Ser Gly Leu Glu Ser Thr Cys Leu Val Val Ala Tyr
         925                 930                 935

 ggt ttg gac att tac caa act cga gtc tac cca tcc aag cag ttt gac     2882
 Gly Leu Asp Ile Tyr Gln Thr Arg Val Tyr Pro Ser Lys Gln Phe Asp
     940                 945                 950

 gtt ctg aag gat gac tat gac tac gtg tta atc agc agc gtc ctc ttt     2930
 Val Leu Lys Asp Asp Tyr Asp Tyr Val Leu Ile Ser Ser Val Leu Phe
 955                 960                 965                 970

 ggc ctg gtt tta gcc acc atg atc act aag aga ctg gca cag gtg aag     2978
 Gly Leu Val Leu Ala Thr Met Ile Thr Lys Arg Leu Ala Gln Val Lys
                 975                 980                 985

 ctc ctg aat cgg gcc tgg cga taa agaacaaaga ctgtgcctaa aagtggagag    3032
 Leu Leu Asn Arg Ala Trp Arg 
             990

 ccaggggagt gtggggc                                                  3049




      <210> 185
      <211> 2607
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (606)..(2465)

      <400> 185
 gctccgggcc accggcagaa ggcccgcctg tacacgacac ggccactgtc taaggtgcca     60

 ggcccccgcg ccgccctccg gcgtcctgtc cgggacggcg caacgtcgtg tgccagccag    120

 tcccagccca cgcgaattac gtaaagtacg tccaagagga gtcccataca gggccccttc    180

 cgtccagaac tctgcccagc ccaggaccag gttccgagat gttaccacca ggcccagagc    240

 tgggcggggg cgtggaaaac gcgagggagc cttcccgccc ccatctccgg tctccctccc    300

 tccccttccc aagccacctg cacggcatcc cagccgagct tccgcccccc gcggtggccc    360

 cgcctccccg ccgcccggaa agacgggctg acggccccct cccgaaaccc ggggaagtgg    420

 attctacgct ccagctccgc tccgctccgc tccgctccgc cccgcaccac caaccccggg    480

 ccgcagtcct gacgagcggg tcagggcttg tcgggcggaa gcctggcctg gagcctggaa    540

 gggggagacg gcccgagcgg gagcgggagc ggacgcggcc tcagtcctgc gcggaatatt    600

 gaagg    atg ttt gtt cca aga tct cta aaa atc aag agg aat gct aat     647
          Met Phe Val Pro Arg Ser Leu Lys Ile Lys Arg Asn Ala Asn
            1               5                  10

 gat gat ggc aaa agt tgt gtg gct aag ata att aaa cca gac cca gaa      695
 Asp Asp Gly Lys Ser Cys Val Ala Lys Ile Ile Lys Pro Asp Pro Glu
  15                  20                  25                  30

 gac ctt cag ttg gac aaa agc aga gat gtt ccc gtt gat gct gta gct      743
 Asp Leu Gln Leu Asp Lys Ser Arg Asp Val Pro Val Asp Ala Val Ala
                  35                  40                  45

 aca gaa gca gcc aca ata gac agg cac atc agc gaa tca tgc cct ttc      791
 Thr Glu Ala Ala Thr Ile Asp Arg His Ile Ser Glu Ser Cys Pro Phe
              50                  55                  60

 ccc agc cca ggt ggc cag ttg gca gag gtt cat tca gta agt ccc gag      839
 Pro Ser Pro Gly Gly Gln Leu Ala Glu Val His Ser Val Ser Pro Glu
          65                  70                  75

 cag ggt gcg aag gac agc cat cct tct gaa gag ccc gtt aag tca ttt      887
 Gln Gly Ala Lys Asp Ser His Pro Ser Glu Glu Pro Val Lys Ser Phe
      80                  85                  90

 tcc aaa aca cag cgc tgg gca gaa cca ggg gaa ccc atc tgt gtt gtc      935
 Ser Lys Thr Gln Arg Trp Ala Glu Pro Gly Glu Pro Ile Cys Val Val
  95                 100                 105                 110

 tgt ggt cgt tat gga gag tat atc tgt gat aag aca gat gaa gat gtg      983
 Cys Gly Arg Tyr Gly Glu Tyr Ile Cys Asp Lys Thr Asp Glu Asp Val
                 115                 120                 125

 tgt agt ttg gag tgt aaa gcg aaa cat ctt cta caa gtt aag gaa aag     1031
 Cys Ser Leu Glu Cys Lys Ala Lys His Leu Leu Gln Val Lys Glu Lys
             130                 135                 140

 gaa gag aaa tca aaa ctc agc aat cca cag aag gct gat tct gag cca     1079
 Glu Glu Lys Ser Lys Leu Ser Asn Pro Gln Lys Ala Asp Ser Glu Pro
         145                 150                 155

 gag tct cca ctg aat gct tcc tat gtc tac aaa gag cac ccc ttt att     1127
 Glu Ser Pro Leu Asn Ala Ser Tyr Val Tyr Lys Glu His Pro Phe Ile
     160                 165                 170

 ttg aac ctt cag gaa gac cag att gaa aat ctt aaa cag cag ctg gga     1175
 Leu Asn Leu Gln Glu Asp Gln Ile Glu Asn Leu Lys Gln Gln Leu Gly
 175                 180                 185                 190

 att tta gtt caa ggg caa gaa gtc acc agg ccc att att gac ttt gaa     1223
 Ile Leu Val Gln Gly Gln Glu Val Thr Arg Pro Ile Ile Asp Phe Glu
                 195                 200                 205

 cat tgt agt ctc cct gag gtc tta aat cac aac ttg aag aaa tca ggc     1271
 His Cys Ser Leu Pro Glu Val Leu Asn His Asn Leu Lys Lys Ser Gly
             210                 215                 220

 tat gag gtg cca act ccc att caa atg cag atg att cct gtg gga ctt     1319
 Tyr Glu Val Pro Thr Pro Ile Gln Met Gln Met Ile Pro Val Gly Leu
         225                 230                 235

 ctg gga aga gac att ctg gcc agt gca gat act ggc tca gga aaa aca     1367
 Leu Gly Arg Asp Ile Leu Ala Ser Ala Asp Thr Gly Ser Gly Lys Thr
     240                 245                 250

 gct gct ttt ctt ctt cct gtt atc atg cga gct tta ttc gag agc aaa     1415
 Ala Ala Phe Leu Leu Pro Val Ile Met Arg Ala Leu Phe Glu Ser Lys
 255                 260                 265                 270

 act cca tct gcg ctc att ctt aca cca acc aga gag tta gcc att cag     1463
 Thr Pro Ser Ala Leu Ile Leu Thr Pro Thr Arg Glu Leu Ala Ile Gln
                 275                 280                 285

 ata gag aga caa gct aaa gaa ttg atg agt ggc ctg cca cgc atg aaa     1511
 Ile Glu Arg Gln Ala Lys Glu Leu Met Ser Gly Leu Pro Arg Met Lys
             290                 295                 300

 act gtg ctt ctt gta ggg ggc tta ccc tta ccc cca cag ctt tat cgt     1559
 Thr Val Leu Leu Val Gly Gly Leu Pro Leu Pro Pro Gln Leu Tyr Arg
         305                 310                 315

 ctg caa caa cat gtt aag gtt atc ata gca acc cct ggg cga ctt ctg     1607
 Leu Gln Gln His Val Lys Val Ile Ile Ala Thr Pro Gly Arg Leu Leu
     320                 325                 330

 gat ata ata aag cag agc tct gta gaa ctc tgt ggt gta aag att gtg     1655
 Asp Ile Ile Lys Gln Ser Ser Val Glu Leu Cys Gly Val Lys Ile Val
 335                 340                 345                 350

 gta gta gat gaa gct gat acc atg tta aag atg ggt ttt caa caa caa     1703
 Val Val Asp Glu Ala Asp Thr Met Leu Lys Met Gly Phe Gln Gln Gln
                 355                 360                 365

 gtg ctt gac att ttg gaa aac att cct aat gat tgt cag acc att ttg     1751
 Val Leu Asp Ile Leu Glu Asn Ile Pro Asn Asp Cys Gln Thr Ile Leu
             370                 375                 380

 gtt tca gcc aca att cca act agc ata gaa cag cta gca agc cag ctt     1799
 Val Ser Ala Thr Ile Pro Thr Ser Ile Glu Gln Leu Ala Ser Gln Leu
         385                 390                 395

 ctg cat aat cct gtg aga att atc act gga gaa aag aac cta cct tgt     1847
 Leu His Asn Pro Val Arg Ile Ile Thr Gly Glu Lys Asn Leu Pro Cys
     400                 405                 410

 gcc aat gta cgt cag att att ttg tgg gta gaa gac cca gcc aaa aag     1895
 Ala Asn Val Arg Gln Ile Ile Leu Trp Val Glu Asp Pro Ala Lys Lys
 415                 420                 425                 430

 aaa aaa tta ttt gaa att tta aat gat aag aaa ctc ttt aag cct cca     1943
 Lys Lys Leu Phe Glu Ile Leu Asn Asp Lys Lys Leu Phe Lys Pro Pro
                 435                 440                 445

 gtg tta gta ttt gtg gac tgc aaa cta gga gca gat ctt ttg agt gaa     1991
 Val Leu Val Phe Val Asp Cys Lys Leu Gly Ala Asp Leu Leu Ser Glu
             450                 455                 460

 gcc gtt cag aaa atc aca ggg ctg aaa agc ata tct ata cat tcg gag     2039
 Ala Val Gln Lys Ile Thr Gly Leu Lys Ser Ile Ser Ile His Ser Glu
         465                 470                 475

 aag tcg caa ata gaa agg aaa aac ata ttg aag gga tta ctt gaa gga     2087
 Lys Ser Gln Ile Glu Arg Lys Asn Ile Leu Lys Gly Leu Leu Glu Gly
     480                 485                 490

 gac tat gaa gtt gta gtg agc aca gga gtc ttg gga cga ggc cta gac     2135
 Asp Tyr Glu Val Val Val Ser Thr Gly Val Leu Gly Arg Gly Leu Asp
 495                 500                 505                 510

 ttg atc agt gtc agg ctg gtt gtc aat ttt gat atg cct tca agt atg     2183
 Leu Ile Ser Val Arg Leu Val Val Asn Phe Asp Met Pro Ser Ser Met
                 515                 520                 525

 gat gag tat gtc cat cag att gga aga gta gga aga tta ggt caa aat     2231
 Asp Glu Tyr Val His Gln Ile Gly Arg Val Gly Arg Leu Gly Gln Asn
             530                 535                 540

 gga aca gcg att act ttc atc aat aat aat tca aaa aga ctc ttc tgg     2279
 Gly Thr Ala Ile Thr Phe Ile Asn Asn Asn Ser Lys Arg Leu Phe Trp
         545                 550                 555

 gat att gca aaa cga gta aag ccc aca gga tcc att ctt ccc cct cag     2327
 Asp Ile Ala Lys Arg Val Lys Pro Thr Gly Ser Ile Leu Pro Pro Gln
     560                 565                 570

 tta tta aat tcc cca tac ctt cat gac cag aag aga aag gaa caa cag     2375
 Leu Leu Asn Ser Pro Tyr Leu His Asp Gln Lys Arg Lys Glu Gln Gln
 575                 580                 585                 590

 aaa gat aaa cag aca cag aat gat ctg gtt aca gga gct aat ctt atg     2423
 Lys Asp Lys Gln Thr Gln Asn Asp Leu Val Thr Gly Ala Asn Leu Met
                 595                 600                 605

 gat att atc aga aaa cat gat aaa agt aat tct cag aaa tga ttttctc     2472
 Asp Ile Ile Arg Lys His Asp Lys Ser Asn Ser Gln Lys 
             610                 615

 tgccacttga atattttttt ttattgtata tagtcagcaa aaaattatgg tttgcataaa   2532

 tggaaatgta catgaatttt aaaaatttta agatattttt aatttaataa aatttatata   2592

 actaaaaaaa aaaaa                                                    2607




      <210> 186
      <211> 1757
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (112)..(1710)

      <400> 186
 gttcgcaccc cagggtctca ccggcaaggg aaggattttc tggagaggga tccctcagga     60

 gggtgtgttc cggatttctt gcctcaggcc caagactcca accattttat a atg gaa     117
                                                          Met Glu
                                                            1

 tct tta ttt tgt gaa agt agc ggg gac tca tct ctg gag aag gag ttc      165
 Ser Leu Phe Cys Glu Ser Ser Gly Asp Ser Ser Leu Glu Lys Glu Phe
           5                  10                  15

 ctc ggg gcc cca gtg ggg ccc tcg gtg agc acc ccc aac agc cag cac      213
 Leu Gly Ala Pro Val Gly Pro Ser Val Ser Thr Pro Asn Ser Gln His
      20                  25                  30

 tct tct cct agc cgc tca ctc agt gcc aac tcc atc aag gtg gag atg      261
 Ser Ser Pro Ser Arg Ser Leu Ser Ala Asn Ser Ile Lys Val Glu Met
  35                  40                  45                  50

 tac agc gat gag gag tca agc aga ctg ctg ggg cca gat gag cgg ctc      309
 Tyr Ser Asp Glu Glu Ser Ser Arg Leu Leu Gly Pro Asp Glu Arg Leu
                  55                  60                  65

 ctg gaa aag gac gac agc gtg att gtg gaa gat tca ttg tct gag ccc      357
 Leu Glu Lys Asp Asp Ser Val Ile Val Glu Asp Ser Leu Ser Glu Pro
              70                  75                  80

 ctg ggc tac tgt gat ggg agt ggg cca gag cct cac tcc cct ggg ggc      405
 Leu Gly Tyr Cys Asp Gly Ser Gly Pro Glu Pro His Ser Pro Gly Gly
          85                  90                  95

 atc cgg ctg ccc aat ggc aag ctc aag tgt gac gtc tgc ggc atg gtc      453
 Ile Arg Leu Pro Asn Gly Lys Leu Lys Cys Asp Val Cys Gly Met Val
     100                 105                 110

 tgt att gga ccc aac gtg ctc atg gtg cac aag cgc agt cac act ggt      501
 Cys Ile Gly Pro Asn Val Leu Met Val His Lys Arg Ser His Thr Gly
 115                 120                 125                 130

 gaa agg ccc ttc cat tgc aac cag tgt ggt gcc tcc ttc acc cag aag      549
 Glu Arg Pro Phe His Cys Asn Gln Cys Gly Ala Ser Phe Thr Gln Lys
                 135                 140                 145

 ggg aac ctg ctg cgc cac atc aag ctg cac tct ggg gag aag ccc ttt      597
 Gly Asn Leu Leu Arg His Ile Lys Leu His Ser Gly Glu Lys Pro Phe
             150                 155                 160

 aaa tgt ccc ttc tgc aac tat gcc tgc cgc cgg cgt gat gca ctc act      645
 Lys Cys Pro Phe Cys Asn Tyr Ala Cys Arg Arg Arg Asp Ala Leu Thr
         165                 170                 175

 ggt cac ctc cgc aca cac tca gtc tcc tct ccc aca gtg ggc aag ccc      693
 Gly His Leu Arg Thr His Ser Val Ser Ser Pro Thr Val Gly Lys Pro
     180                 185                 190

 tac aag tgt aac tac tgt ggc cgg agc tac aaa cag cag agt acc ctg      741
 Tyr Lys Cys Asn Tyr Cys Gly Arg Ser Tyr Lys Gln Gln Ser Thr Leu
 195                 200                 205                 210

 gag gag cac aag gag cgg tgc cat aac tac cta cag agt ctc agc act      789
 Glu Glu His Lys Glu Arg Cys His Asn Tyr Leu Gln Ser Leu Ser Thr
                 215                 220                 225

 gaa gcc caa gct ttg gct ggc caa cca ggt gac gaa ata cgt gac ctg      837
 Glu Ala Gln Ala Leu Ala Gly Gln Pro Gly Asp Glu Ile Arg Asp Leu
             230                 235                 240

 gag atg gtg cca gac tcc atg ctg cac tca tcc tct gag cgg cca act      885
 Glu Met Val Pro Asp Ser Met Leu His Ser Ser Ser Glu Arg Pro Thr
         245                 250                 255

 ttc atc gat cgt ctg gcc aat agc ctc acc aaa cgc aag cgt tcc aca      933
 Phe Ile Asp Arg Leu Ala Asn Ser Leu Thr Lys Arg Lys Arg Ser Thr
     260                 265                 270

 ccc cag aag ttt gta ggc gaa aag cag atg cgc ttc agc ctc tca gac      981
 Pro Gln Lys Phe Val Gly Glu Lys Gln Met Arg Phe Ser Leu Ser Asp
 275                 280                 285                 290

 ctc ccc tat gat gtg aac tcg ggt ggc tat gaa aag gat gtg gag ttg     1029
 Leu Pro Tyr Asp Val Asn Ser Gly Gly Tyr Glu Lys Asp Val Glu Leu
                 295                 300                 305

 gtg gca cac cac agc cta gag cct ggc ttt gga agt tcc ctg gcc ttt     1077
 Val Ala His His Ser Leu Glu Pro Gly Phe Gly Ser Ser Leu Ala Phe
             310                 315                 320

 gtg ggt gca gag cat ctg cgt ccc ctc cgc ctt cca ccc acc aat tgc     1125
 Val Gly Ala Glu His Leu Arg Pro Leu Arg Leu Pro Pro Thr Asn Cys
         325                 330                 335

 atc tca gaa ctc acg cct gtc atc agc tct gtc tac acc cag atg cag     1173
 Ile Ser Glu Leu Thr Pro Val Ile Ser Ser Val Tyr Thr Gln Met Gln
     340                 345                 350

 ccc ctc cct ggt cga ctg gag ctt cca gga tcc cga gaa gca ggt gag     1221
 Pro Leu Pro Gly Arg Leu Glu Leu Pro Gly Ser Arg Glu Ala Gly Glu
 355                 360                 365                 370

 gga cct gag gac ctg gct gat gga ggt ccc ctc ctc tac cgg ccc cga     1269
 Gly Pro Glu Asp Leu Ala Asp Gly Gly Pro Leu Leu Tyr Arg Pro Arg
                 375                 380                 385

 ggc ccc ctg act gac cct ggg gca tcc ccc agc aat ggc tgc cag gac     1317
 Gly Pro Leu Thr Asp Pro Gly Ala Ser Pro Ser Asn Gly Cys Gln Asp
             390                 395                 400

 tcc aca gac aca gaa agc aac cac gaa gat cgg gtt gcg ggg gtg gta     1365
 Ser Thr Asp Thr Glu Ser Asn His Glu Asp Arg Val Ala Gly Val Val
         405                 410                 415

 tcc ctc cct cag ggt ccc cca ccc cag cca cct ccc acc att gtg gtg     1413
 Ser Leu Pro Gln Gly Pro Pro Pro Gln Pro Pro Pro Thr Ile Val Val
     420                 425                 430

 ggc cgg cac agt cct gcc tac gcc aaa gag gac ccc aag cca cag gag     1461
 Gly Arg His Ser Pro Ala Tyr Ala Lys Glu Asp Pro Lys Pro Gln Glu
 435                 440                 445                 450

 ggg tta ttg cgg ggc acc cca ggc ccc tcc aag gaa gtg ctt cgg gtg     1509
 Gly Leu Leu Arg Gly Thr Pro Gly Pro Ser Lys Glu Val Leu Arg Val
                 455                 460                 465

 gtg ggc gag agt ggt gag cct gtg aag gcc ttc aag tgt gag cac tgc     1557
 Val Gly Glu Ser Gly Glu Pro Val Lys Ala Phe Lys Cys Glu His Cys
             470                 475                 480

 cgt atc ctc ttc ctg gac cac gtc atg ttc act atc cac atg ggc tgc     1605
 Arg Ile Leu Phe Leu Asp His Val Met Phe Thr Ile His Met Gly Cys
         485                 490                 495

 cat ggc ttc aga gac cct ttt gag tgc aac atc tgt ggt tat cac agc     1653
 His Gly Phe Arg Asp Pro Phe Glu Cys Asn Ile Cys Gly Tyr His Ser
     500                 505                 510

 cag gac cgg tac gaa ttc tct tcc cac att gtc cgg ggg gag cat aag     1701
 Gln Asp Arg Tyr Glu Phe Ser Ser His Ile Val Arg Gly Glu His Lys
 515                 520                 525                 530

 gtg ggc tag caacctc tccctctctc ctcagtccac cactccactg ccctgactac     1757
 Val Gly 






      <210> 187
      <211> 2824
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2079)

      <400> 187
  atg aag aga aaa tgt gtt ctg att gat ggc aat gtt agg cca aaa agc      48
  Met Lys Arg Lys Cys Val Leu Ile Asp Gly Asn Val Arg Pro Lys Ser
    1               5                  10                  15

 att cag cta cat gaa gac ttc agc aag gga tcc cct aaa act agt gac       96
 Ile Gln Leu His Glu Asp Phe Ser Lys Gly Ser Pro Lys Thr Ser Asp
              20                  25                  30

 atc aag cca ttt act gca agt gga aaa ata tgg aag aat atc cag gaa      144
 Ile Lys Pro Phe Thr Ala Ser Gly Lys Ile Trp Lys Asn Ile Gln Glu
          35                  40                  45

 aac aaa aat aaa agc tat gaa agg gga cta cat cta cca gtc act aaa      192
 Asn Lys Asn Lys Ser Tyr Glu Arg Gly Leu His Leu Pro Val Thr Lys
      50                  55                  60

 aca tat tct aag gcc tct aaa ata aaa aca gtg gtc ctg gtg cat gac      240
 Thr Tyr Ser Lys Ala Ser Lys Ile Lys Thr Val Val Leu Val His Asp
  65                  70                  75                  80

 aag aaa gag cag tac aac cga aaa gaa agt cca gaa gta aac cca aat      288
 Lys Lys Glu Gln Tyr Asn Arg Lys Glu Ser Pro Glu Val Asn Pro Asn
                  85                  90                  95

 aca tat ggg aat tta gta tgc aat aaa ggt ggc atc tca aat cac ttg      336
 Thr Tyr Gly Asn Leu Val Cys Asn Lys Gly Gly Ile Ser Asn His Leu
             100                 105                 110

 gac aaa gat gga ctt aac aat tgg tgt acg cgt cag cgg ggc agg aaa      384
 Asp Lys Asp Gly Leu Asn Asn Trp Cys Thr Arg Gln Arg Gly Arg Lys
         115                 120                 125

 cgg aaa gac agt gca gta att ggt gga aag ctg gaa gtg ggc acc tcg      432
 Arg Lys Asp Ser Ala Val Ile Gly Gly Lys Leu Glu Val Gly Thr Ser
     130                 135                 140

 agg gcc tca gcc cca cga aca cag tca ccc agg aaa agc gaa ccg cgc      480
 Arg Ala Ser Ala Pro Arg Thr Gln Ser Pro Arg Lys Ser Glu Pro Arg
 145                 150                 155                 160

 cag gcc ctg tca tcg acc gct ggg tcc gtc ctc cca gcg ctc gcg gcc      528
 Gln Ala Leu Ser Ser Thr Ala Gly Ser Val Leu Pro Ala Leu Ala Ala
                 165                 170                 175

 gct cac atg ggc gtg gcc ctg cgt gac ctg ccg ggg cgt cac gtg agc      576
 Ala His Met Gly Val Ala Leu Arg Asp Leu Pro Gly Arg His Val Ser
             180                 185                 190

 tcc cgg agt cat gtg acc gcc gtc ttg aca gtg ttc cac ggg cgc tgc      624
 Ser Arg Ser His Val Thr Ala Val Leu Thr Val Phe His Gly Arg Cys
         195                 200                 205

 ttc ctg cct ggg ttt gga gtt gtc acc act ttc ccc tct ccg tct cct      672
 Phe Leu Pro Gly Phe Gly Val Val Thr Thr Phe Pro Ser Pro Ser Pro
     210                 215                 220

 gcg ggc gca atg gag gag gag gat gag gaa gcg cgg gcg ctc ctg gca      720
 Ala Gly Ala Met Glu Glu Glu Asp Glu Glu Ala Arg Ala Leu Leu Ala
 225                 230                 235                 240

 ggc ggc cct gac gag gcc gac aga ggt gcc ccg gcc gcc cct gga gcc      768
 Gly Gly Pro Asp Glu Ala Asp Arg Gly Ala Pro Ala Ala Pro Gly Ala
                 245                 250                 255

 ctg ccg gcc ctc tgc gac ccc agt cgc ctg gcg cac cgg ctt ttg gtg      816
 Leu Pro Ala Leu Cys Asp Pro Ser Arg Leu Ala His Arg Leu Leu Val
             260                 265                 270

 ctg tta ctg atg tgc ttc ctt ggc ttt ggc agc tat ttt tgc tat gat      864
 Leu Leu Leu Met Cys Phe Leu Gly Phe Gly Ser Tyr Phe Cys Tyr Asp
         275                 280                 285

 aat cct gct gcc ctt cag act caa gtt aaa cga gat atg caa gtg aat      912
 Asn Pro Ala Ala Leu Gln Thr Gln Val Lys Arg Asp Met Gln Val Asn
     290                 295                 300

 acc acg aaa ttc atg ctg ctg tat gcc tgg tat tct tgg ccc aat gta      960
 Thr Thr Lys Phe Met Leu Leu Tyr Ala Trp Tyr Ser Trp Pro Asn Val
 305                 310                 315                 320

 gtt ttg tgt ttc ttt ggt ggc ttt ttg ata gac cga gta ttt gga ata     1008
 Val Leu Cys Phe Phe Gly Gly Phe Leu Ile Asp Arg Val Phe Gly Ile
                 325                 330                 335

 cga tgg ggc aca atc att ttt agc tgc ttt gtt tgc att gga cag gtt     1056
 Arg Trp Gly Thr Ile Ile Phe Ser Cys Phe Val Cys Ile Gly Gln Val
             340                 345                 350

 gtt ttt gcc ctg ggt gga ata ttt aat gct ttt tgg ctg atg gaa ttt     1104
 Val Phe Ala Leu Gly Gly Ile Phe Asn Ala Phe Trp Leu Met Glu Phe
         355                 360                 365

 gga aga ttt gta ttt ggg att ggt ggc gag tcc tta gca gtt gcc cag     1152
 Gly Arg Phe Val Phe Gly Ile Gly Gly Glu Ser Leu Ala Val Ala Gln
     370                 375                 380

 aat aca tat gct gtg agc tgg ttt aaa ggc aaa gaa tta aac ctg gtg     1200
 Asn Thr Tyr Ala Val Ser Trp Phe Lys Gly Lys Glu Leu Asn Leu Val
 385                 390                 395                 400

 ttt gga ctt caa ctt agc atg gct aga att gga agt aca gta aac atg     1248
 Phe Gly Leu Gln Leu Ser Met Ala Arg Ile Gly Ser Thr Val Asn Met
                 405                 410                 415

 aac ctc atg gga tgg ctg tat tct aag att gaa gct ttg tta ggt tct     1296
 Asn Leu Met Gly Trp Leu Tyr Ser Lys Ile Glu Ala Leu Leu Gly Ser
             420                 425                 430

 gct ggt cac aca acc ctc ggg atc aca ctt atg att ggg ggt gta acg     1344
 Ala Gly His Thr Thr Leu Gly Ile Thr Leu Met Ile Gly Gly Val Thr
         435                 440                 445

 tgt att ctt tca cta atc tgt gcc ttg gct ctt gcc tac ttg gat cag     1392
 Cys Ile Leu Ser Leu Ile Cys Ala Leu Ala Leu Ala Tyr Leu Asp Gln
     450                 455                 460

 aga gca gag aga atc ctt cat aaa gaa caa gga aaa aca ggt gaa gtt     1440
 Arg Ala Glu Arg Ile Leu His Lys Glu Gln Gly Lys Thr Gly Glu Val
 465                 470                 475                 480

 att aaa tta act gat gta aag gac ttc tcc tta ccc ctg tgg ctt ata     1488
 Ile Lys Leu Thr Asp Val Lys Asp Phe Ser Leu Pro Leu Trp Leu Ile
                 485                 490                 495

 ttt atc atc tgt gtc tgc tat tat gtt gct gtg ttc cct ttt att gga     1536
 Phe Ile Ile Cys Val Cys Tyr Tyr Val Ala Val Phe Pro Phe Ile Gly
             500                 505                 510

 ctt ggg aaa gtt ttc ttt aca gag aaa ttt gga ttt tct tcc cag gca     1584
 Leu Gly Lys Val Phe Phe Thr Glu Lys Phe Gly Phe Ser Ser Gln Ala
         515                 520                 525

 gca agt gca att aac agt gtt gta tat gtc ata tca gct ccc atg tcc     1632
 Ala Ser Ala Ile Asn Ser Val Val Tyr Val Ile Ser Ala Pro Met Ser
     530                 535                 540

 ccg gtg ttt ggg ctc ctg gtg gat aaa aca ggg aag aac atc atc tgg     1680
 Pro Val Phe Gly Leu Leu Val Asp Lys Thr Gly Lys Asn Ile Ile Trp
 545                 550                 555                 560

 gtt ctt tgc gca gta gca gcc act ctt gtg tcc cac atg atg ctg gcc     1728
 Val Leu Cys Ala Val Ala Ala Thr Leu Val Ser His Met Met Leu Ala
                 565                 570                 575

 ttt acg atg tgg aac cct tgg att gct atg tgt ctt ctg gga ctc tcc     1776
 Phe Thr Met Trp Asn Pro Trp Ile Ala Met Cys Leu Leu Gly Leu Ser
             580                 585                 590

 tac tca ttg ctt gcc tgt gca ttg tgg cca atg gtg gca ttt gta gtt     1824
 Tyr Ser Leu Leu Ala Cys Ala Leu Trp Pro Met Val Ala Phe Val Val
         595                 600                 605

 cct gaa cat cag ctg gga act gca tat ggc ttc atg cag tcc att cag     1872
 Pro Glu His Gln Leu Gly Thr Ala Tyr Gly Phe Met Gln Ser Ile Gln
     610                 615                 620

 aat ctt ggg ttg gcc atc att tcc atc att gct ggt atg ata ctg gat     1920
 Asn Leu Gly Leu Ala Ile Ile Ser Ile Ile Ala Gly Met Ile Leu Asp
 625                 630                 635                 640

 tct cgg ggg tat ttg ttt ttg gaa gtg ttc ttc att gcc tgt gtt tct     1968
 Ser Arg Gly Tyr Leu Phe Leu Glu Val Phe Phe Ile Ala Cys Val Ser
                 645                 650                 655

 ttg tca ctt tta tct gtg gtc tta ctc tat ttg gtg aat cgt gcc cag     2016
 Leu Ser Leu Leu Ser Val Val Leu Leu Tyr Leu Val Asn Arg Ala Gln
             660                 665                 670

 ggt ggg aac cta aat tat tct gca aga caa agg gaa gaa ata aaa ttt     2064
 Gly Gly Asn Leu Asn Tyr Ser Ala Arg Gln Arg Glu Glu Ile Lys Phe
         675                 680                 685

 tcc cat act gaa tga gaagttaaaa tgaatgtgtc atgagaatgg gcttaacaca     2119
 Ser His Thr Glu 
     690

 tcgttggttt gaaaacttcc atttttaaaa atttagagtt ttagtcatta gaaaaaataa   2179

 tggactggaa agttatattt atatccaaat atacctattt caaagtgtat ttgtgaggcc   2239

 tgttttagcc tgtgtctttt gtattgtgtg ttgctaaaga attctacttt tagtaggcta   2299

 atcaacaatg aaagggttag aaaattgctg tggaacatcc aggtgaactt caggaaagac   2359

 agtgaaaaat ggaaaacgtt ggagcttctg ttgagataat cttcattagg tatatatctt   2419

 agggatacag ccttttcttt atcttatagc aggaaaaaaa aacttttgag ggaaatagaa   2479

 gggctgcgtt acacaaaata aacaatggca ttgtcatagg ccttcctttt actagtaggg   2539

 cataatgcta gggaatatgt gaagatgttt ttatgaagtc tctttctgat cacgaacaat   2599

 agcttgcgct ctactctgta gttatgtgga ttgccgagca atgacccttt tcaatttctt   2659

 atttctgtgt tactgaggac cctaatcact tagggatgta attttatagt ataaactttc   2719

 tgtacagttt ttcttatagt ctaataagta aaaagtgtcc ttcaaattat gataattgcc   2779

 tatgtacatg gataaattaa aacactgcac acggaaaaaa aaaaa                   2824




      <210> 188
      <211> 1215
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (13)..(612)

      <400> 188
 gcggagtgtg cc    atg agc gag agg gag gct gcc cca aat gag gaa ttg      48
                  Met Ser Glu Arg Glu Ala Ala Pro Asn Glu Glu Leu
                    1               5                  10

 gtg caa aga aac agg tta ata tgc aga aga aat cca tat agg atc ttt       96
 Val Gln Arg Asn Arg Leu Ile Cys Arg Arg Asn Pro Tyr Arg Ile Phe
          15                  20                  25

 gag tat ttg caa ctc agc cta gaa gag gcc ttt ttc ttg gtc tat gct      144
 Glu Tyr Leu Gln Leu Ser Leu Glu Glu Ala Phe Phe Leu Val Tyr Ala
      30                  35                  40

 ctg gga tgt tta agt att tac tat gag aag gag cct tta acg ata gtg      192
 Leu Gly Cys Leu Ser Ile Tyr Tyr Glu Lys Glu Pro Leu Thr Ile Val
  45                  50                  55                  60

 aag ctc tgg aaa gct ttc act gta gtt cag ccc acg ttc aga acc acc      240
 Lys Leu Trp Lys Ala Phe Thr Val Val Gln Pro Thr Phe Arg Thr Thr
                  65                  70                  75

 tac atg gcc tac cat tac ttt cga agc aag ggc tgg gtg ccc aaa gtg      288
 Tyr Met Ala Tyr His Tyr Phe Arg Ser Lys Gly Trp Val Pro Lys Val
              80                  85                  90

 gga ctc aag tac ggg aca gat tta ctg cta tat cgg aaa ggc cct cca      336
 Gly Leu Lys Tyr Gly Thr Asp Leu Leu Leu Tyr Arg Lys Gly Pro Pro
          95                 100                 105

 ttt tac cat gca agt tat tct gtc att atc gag cta gtt gat gac cat      384
 Phe Tyr His Ala Ser Tyr Ser Val Ile Ile Glu Leu Val Asp Asp His
     110                 115                 120

 ttt gaa ggc tct ctc cgc agg cct ctc agt tgg aag tcc ctg gct gcc      432
 Phe Glu Gly Ser Leu Arg Arg Pro Leu Ser Trp Lys Ser Leu Ala Ala
 125                 130                 135                 140

 ttg agc aga gtt tcc gtt aat gtc tct aag gaa ctt atg ctg tgc tat      480
 Leu Ser Arg Val Ser Val Asn Val Ser Lys Glu Leu Met Leu Cys Tyr
                 145                 150                 155

 ttg att aaa ccc tct act atg act gac aag gaa atg gag tca cca gaa      528
 Leu Ile Lys Pro Ser Thr Met Thr Asp Lys Glu Met Glu Ser Pro Glu
             160                 165                 170

 tgt atg aaa agg att aaa gtt cag gag gtg att ctg agt cga tgg gtt      576
 Cys Met Lys Arg Ile Lys Val Gln Glu Val Ile Leu Ser Arg Trp Val
         175                 180                 185

 tct tca cga gag agg agt gac caa gac gat ctt taa caat tcaacctcaa      626
 Ser Ser Arg Glu Arg Ser Asp Gln Asp Asp Leu 
     190                 195

 atttctaatt tcaccaacaa ctatttattg agggctaggt aaaaagttct ttttgttgta    686

 atcgtccatt aattcataag ttttaaaggg catggtgctc ccagcaccag aaaactatca    746

 gtgtttttaa agataaatta cacaagggag gagaaagatc cctgtgctag gactgcagat    806

 tctatacttg cgttggcctc taactctcca atccagagcc tcctgcctct ggcgtcagtc    866

 ttttccctca tccactcact ggggagattg gactagagga gtcctgagag gacacttcca    926

 acaagagaca tttattctct gattttacct gaaaatggta gtagtttaca tttatacagt    986

 acagtttatg aagcactttc atacgcaggc atctcttgtt acctacatct aagctgttcc   1046

 cgaaagagtg ttacagaaca caacagtatt gtacaatatt cgataagcat atcttcactg   1106

 cacttgttat aaaaatgagt ggtgaaataa tgtttggaga cataatgaaa gcgattaaca   1166

 tttggcaaaa tataataaag cctttttgta attggtgaaa aaaaaaaaa               1215




      <210> 189
      <211> 5854
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(2078)

      <400> 189
 cgcccgggga aggcgggcca tgggcgcggg tgcgggcgcc ccagccggcc gcgatcgcgg     60

 gatttctgcg ccaggagatg aggggcggta gagccctgga atggagatgt ccttgacgcc    120

 tgggcagagg ctgcagctgc aggaccctgt ggccactgga gataagtaat ggtgccattt    180

 gaacacctac tggaaacggg gcaggaacag tgagtgaccc caggcgagca caggcaggtg    240

 ccaggagcca ggatgcaagg    atg acg cct ccg gag gcc ctg gcc tca ctt     290
                          Met Thr Pro Pro Glu Ala Leu Ala Ser Leu
                            1               5                  10

 ccc acc tgg gcg cta gga gcc atc ccg ggg ctc cag cca gga gcc ctg      338
 Pro Thr Trp Ala Leu Gly Ala Ile Pro Gly Leu Gln Pro Gly Ala Leu
                  15                  20                  25

 ctg ccc agg ggc atg gcc aaa cct ttc ttc cga ctc cag aag ttt ctc      386
 Leu Pro Arg Gly Met Ala Lys Pro Phe Phe Arg Leu Gln Lys Phe Leu
              30                  35                  40

 cgc cga aca cag ttc ctg ctg ttc ttc ctc acg gct gcc tac ctg atg      434
 Arg Arg Thr Gln Phe Leu Leu Phe Phe Leu Thr Ala Ala Tyr Leu Met
          45                  50                  55

 acc ggc agc ctg ctg ctg ctg cag cgg gtc cgc gtg gct ctc cca cag      482
 Thr Gly Ser Leu Leu Leu Leu Gln Arg Val Arg Val Ala Leu Pro Gln
      60                  65                  70

 ggc ccc cgg gca ccc ggc ccc ctg cag acc ttg cca gtg gcc gcc gtg      530
 Gly Pro Arg Ala Pro Gly Pro Leu Gln Thr Leu Pro Val Ala Ala Val
  75                  80                  85                  90

 gcg ctg ggc gtg ggc ttg ctg gac agc aga gcc ctg cac gac cct cga      578
 Ala Leu Gly Val Gly Leu Leu Asp Ser Arg Ala Leu His Asp Pro Arg
                  95                 100                 105

 gtc agc cca gag ctg ctg ctg ggt gtg gac atg ctg cag agc ccc ctg      626
 Val Ser Pro Glu Leu Leu Leu Gly Val Asp Met Leu Gln Ser Pro Leu
             110                 115                 120

 acc cgg ccc cgg ccc ggc ccc cgc tgg ctc cgg agc cgc aac tcg gag      674
 Thr Arg Pro Arg Pro Gly Pro Arg Trp Leu Arg Ser Arg Asn Ser Glu
         125                 130                 135

 ctg cgt cag ttg cgt cgc cgc tgg ttc cac cac ttc atg agt gac tcc      722
 Leu Arg Gln Leu Arg Arg Arg Trp Phe His His Phe Met Ser Asp Ser
     140                 145                 150

 cag gga ccg ccc gcc ctg ggc ccc gag gct gcc agg ccc gcc atc cac      770
 Gln Gly Pro Pro Ala Leu Gly Pro Glu Ala Ala Arg Pro Ala Ile His
 155                 160                 165                 170

 agc cga ggc acc tac att gga tgc ttc agt gac gat ggc cat gag agg      818
 Ser Arg Gly Thr Tyr Ile Gly Cys Phe Ser Asp Asp Gly His Glu Arg
                 175                 180                 185

 act ctg aaa gga gct gtg ttt tat gac ttg aga aag atg act gtc tcc      866
 Thr Leu Lys Gly Ala Val Phe Tyr Asp Leu Arg Lys Met Thr Val Ser
             190                 195                 200

 cac tgc cag gat gcg tgt gct gag cgg tcc tat gtc tac gcc ggc ttg      914
 His Cys Gln Asp Ala Cys Ala Glu Arg Ser Tyr Val Tyr Ala Gly Leu
         205                 210                 215

 gag gcc ggg gcg gag tgt tac tgc ggg aac cgg ctg cca gcg gtg agc      962
 Glu Ala Gly Ala Glu Cys Tyr Cys Gly Asn Arg Leu Pro Ala Val Ser
     220                 225                 230

 gtg ggg ctg gaa gag tgt aac cat gag tgc aaa ggc gag aag ggc tct     1010
 Val Gly Leu Glu Glu Cys Asn His Glu Cys Lys Gly Glu Lys Gly Ser
 235                 240                 245                 250

 gtg tgc ggg gct gtg gac cgg ctc tcc gtg tac cgt gtg gac gag ctg     1058
 Val Cys Gly Ala Val Asp Arg Leu Ser Val Tyr Arg Val Asp Glu Leu
                 255                 260                 265

 cag ccg ggc tcc agg aag cgg cgg acc gcc acc tac cgc gga tgc ttc     1106
 Gln Pro Gly Ser Arg Lys Arg Arg Thr Ala Thr Tyr Arg Gly Cys Phe
             270                 275                 280

 cga ctg cca gag aac atc aca cat gcc ttc ccc agc tcc ctg ata cag     1154
 Arg Leu Pro Glu Asn Ile Thr His Ala Phe Pro Ser Ser Leu Ile Gln
         285                 290                 295

 gcc aat gtg acc gtg ggg act tgc tcg ggc ttt tgt tcc cag aaa gag     1202
 Ala Asn Val Thr Val Gly Thr Cys Ser Gly Phe Cys Ser Gln Lys Glu
     300                 305                 310

 ttc ccc ttg gcc att ctc agg ggc tgg gaa tgc tac tgt gct tac cct     1250
 Phe Pro Leu Ala Ile Leu Arg Gly Trp Glu Cys Tyr Cys Ala Tyr Pro
 315                 320                 325                 330

 acc ccc cgg ttc aac ctg cgg gat gcc atg gac agc tca gta tgt ggc     1298
 Thr Pro Arg Phe Asn Leu Arg Asp Ala Met Asp Ser Ser Val Cys Gly
                 335                 340                 345

 cag gac cct gag gca cag agg ctg gca gaa tac tgt gag gtc tac cag     1346
 Gln Asp Pro Glu Ala Gln Arg Leu Ala Glu Tyr Cys Glu Val Tyr Gln
             350                 355                 360

 aca cct gtg caa gac act cgt tgt aca gac agg agg ttc ctg cct aac     1394
 Thr Pro Val Gln Asp Thr Arg Cys Thr Asp Arg Arg Phe Leu Pro Asn
         365                 370                 375

 aaa tcc aaa gtg ttt gtg gct ttg tca agc ttc cca gga gcc ggg aac     1442
 Lys Ser Lys Val Phe Val Ala Leu Ser Ser Phe Pro Gly Ala Gly Asn
     380                 385                 390

 acg tgg gca cgg cac ctc att gag cat gcc act ggc ttc tat aca ggg     1490
 Thr Trp Ala Arg His Leu Ile Glu His Ala Thr Gly Phe Tyr Thr Gly
 395                 400                 405                 410

 agc tac tac ttt gat gga acc ctc tac aac aaa ggg ttc aag ggc gaa     1538
 Ser Tyr Tyr Phe Asp Gly Thr Leu Tyr Asn Lys Gly Phe Lys Gly Glu
                 415                 420                 425

 aag gac cac tgg cgg agc cga cgc acc atc tgt gtc aaa acc cac gag     1586
 Lys Asp His Trp Arg Ser Arg Arg Thr Ile Cys Val Lys Thr His Glu
             430                 435                 440

 agt ggc agg agg gag att gag atg ttt gat tca gcc atc ctg cta atc     1634
 Ser Gly Arg Arg Glu Ile Glu Met Phe Asp Ser Ala Ile Leu Leu Ile
         445                 450                 455

 cgg aac cca tac agg tcc ctg gtg gca gaa ttc aac aga aaa tgt gcc     1682
 Arg Asn Pro Tyr Arg Ser Leu Val Ala Glu Phe Asn Arg Lys Cys Ala
     460                 465                 470

 ggg cac ctg gga tat gca gct gac cgc aac tgg aag agc aaa gag tgg     1730
 Gly His Leu Gly Tyr Ala Ala Asp Arg Asn Trp Lys Ser Lys Glu Trp
 475                 480                 485                 490

 ccg gac ttt gtc aac agc tac gcc tcg tgg tgg tcc tcg cac gtc ctg     1778
 Pro Asp Phe Val Asn Ser Tyr Ala Ser Trp Trp Ser Ser His Val Leu
                 495                 500                 505

 gac tgg ctc aag tac ggg aag cgg ctg ctg gtg gtg cac tac gag gag     1826
 Asp Trp Leu Lys Tyr Gly Lys Arg Leu Leu Val Val His Tyr Glu Glu
             510                 515                 520

 ctg cgg cgc agc ctg gtg ccc acg tta cgg gag atg gtg gcc ttc ctc     1874
 Leu Arg Arg Ser Leu Val Pro Thr Leu Arg Glu Met Val Ala Phe Leu
         525                 530                 535

 aac gtg tct gtg agc gag gag cgg ctg ctc tgc gtg gag aac aac aag     1922
 Asn Val Ser Val Ser Glu Glu Arg Leu Leu Cys Val Glu Asn Asn Lys
     540                 545                 550

 gag ggc agc ttc cgg cgg cgc ggc cgg cgc tcc cac gac cct gag ccc     1970
 Glu Gly Ser Phe Arg Arg Arg Gly Arg Arg Ser His Asp Pro Glu Pro
 555                 560                 565                 570

 ttc acc ccg gag atg aaa gac ttg atc aat ggc tac atc cgg acg gtg     2018
 Phe Thr Pro Glu Met Lys Asp Leu Ile Asn Gly Tyr Ile Arg Thr Val
                 575                 580                 585

 gac caa gcc ctg cgt gac cac aac tgg acg ggg ctg ccc agg gag tat     2066
 Asp Gln Ala Leu Arg Asp His Asn Trp Thr Gly Leu Pro Arg Glu Tyr
             590                 595                 600

 gtg ccc aga tga tag gcctggccca cgccgccgcc cccgctgagt gacgcaatcg     2121
 Val Pro Arg 
         605

 caccacgggg ctgcgctccc cactctgatg ctcaggcccg tggcctcact gggacgaacg   2181

 gtgggtgggg ggctcaccct ggtgctgcct cccgcacaag gagacctgga cacaacagac   2241

 acacatcaca aggcgaacac aaatggacac acatacctgg ccacgaaccc acacctcctc   2301

 agacactcag acaccactcc aggctcatag ccccgtcttg atgcagagaa gccacccacg   2361

 tggggtgtgc caggcacccc cagctacaaa tgcagccacg cacagacgta acacacaggt   2421

 gccaggccgt gtgctcctgg aggctggctg gctgtctctc tcacacagat acacgtgcgc   2481

 tccctgggat ccgggaggcc ctgggcttcc tgtgtgtagc cctggcatag acttgctcgt   2541

 cagggtgttc gactctggga tgctgggccg ggcagacatt tatgctctga gcagcaagga   2601

 ccattgggat ggaggtgggc acaaagactg ctgcttccag ggtgtgcggc cctggccgtg   2661

 tgtctgacat cccataaatg tgtgtgtggt gtgactacgg gcaccacaaa ctccgcagcc   2721

 ttgcctctct tttctctgtg gctgggctgg ctgcaccatg ggcagggttg aggactgccc   2781

 cccaccccgc ccaagccaat gcagacactg acctcaagac cagccacacc aagtctgtgc   2841

 actgcccacc acccccttcg acccctccta caccatgctc ctgggcctgg ggcctccttg   2901

 cctggcttct tcctccagct atcctcaggg aagctggaga ttcaagtcat gccccagaag   2961

 caaggtgtaa gcatgggggc gtggggaaga gggcaggagc tgaagttcca ggggagccca   3021

 ggacccctgg ggacctgtac actagcagga tgggtcttgg gagttggcat ggggagattg   3081

 taagggctgt atctccgcga ttactggtac tggtgctcca cccatagggg ccctgttctc   3141

 tctggggtcc cacactgggg tcatgagagc tagttctcat gagagcagga cccctaggtc   3201

 tggtcctgcc agcctgggat gggggtcaat gtatgctaca catcttgggc tcacaagtga   3261

 ggctgtggag gccaggaggt tcaagtatgg agggtaggag tgcaacccag gagcaacgct   3321

 caaggtggcc gagatgcagg gaggattgtg gcgatccggt tgcacactgg cctctgtgga   3381

 ggtcagggag gtgggaaggt gggtgggcct gaactcaggc agcccttcag tggcttcttc   3441

 aggcctagga taaccctggc caggccccat ggtcctgctc tgggtcagct gtcagggaga   3501

 cctcccttca gcctgagcca agctgcattg ggaggagaag gcagggtgag ggatctggga   3561

 gagcaggatg ttgagatatc ctgaccctct gcttcctagc ctgatgatgg ggaacacaga   3621

 gccacccgct atgagcacag gccgggggtg gaaggcccag tagagctgcc cttccccaga   3681

 tggaagcttc ctccaacctt cagtttggcc agtgggtggg tttgggcatc tgtgcccctg   3741

 gtggcctcca aatccttcct gggattcccc caaacccaca ctgatgcgaa gctgttcttg   3801

 accctcccat agcatcaact cagttcagct caaagctaga aacaccaagg tctttgaaaa   3861

 tgtttattgg ctcaggatag cttcagcatc caatctgcga aggcccctga tggagctatt   3921

 tcttcctagt atcaggagca attgagaccc ctcaggagtt tccacactgc tgtggacggg   3981

 atagccaggg cagacctgca tcccagagca agcctagatc cttgaaagca atgtcaggcg   4041

 tggcagtggg gaagccatgg aggctgggaa gggcaaagtg tggagagagg agtgaccggg   4101

 actggagcca gggtctgggg agagcaacag caccaggctt ttcctggtag ttggattggt   4161

 acattcactg ctgccaggta cccagagatg tcatctctct ccaggtagag catcaccagc   4221

 tcctgtggcc ttgtagatga ctctgtacct cagtgaagag tgcaggcaag tagagtgatg   4281

 gggtcagtgt ccatccagtt tacgctgagt cagtccatac agcaagacac ctggcacttg   4341

 gcaggtactc ctggatgttg atgagcaagg aagagcaacg gccctgtcag ctggcagtgg   4401

 tcctcacagc cttcatccca ggtctgccta cgtgggagat ctcatcagaa acaggaacgg   4461

 ggatctgtct gtgcttgcag gaaagtccat ttgtttttct ccaagttagg tctcatctac   4521

 agctcttagc ttctcagtaa agaggatact ctcccaacca gccaaggaat aaaagctgat   4581

 ctgtatgtag ggcagaagtg tggcaaatgc atcaggaacc ggttagaaca gaacagagaa   4641

 accctgactg tctacagatt ccaactttaa tagcaagcct gtggagttac acaaacctgt   4701

 gttaaaacat gtaattttta tggatttcat ctcccgttgt ggatcaattt ggaaaaacca   4761

 aaatatgtaa ttttaaaaaa ctaaaacaca tcctggtagt cccagtgatg tgtaaatgag   4821

 agagaagaat agacaggctt ccaaaccctg ggaagaaagc tgcttaatta tgtgaacatc   4881

 ttataatgaa gtctcttgca gctaaaatta gattttgagt gcatgaatct gtgataatgt   4941

 ttgcatatca gaatgcattc tccccttaaa agtagcagta gccacttggt tcttaggggg   5001

 ccccaagagg agaggagaag tgctgaggtt gatgttacga ctgcaagaat tcttgggaca   5061

 caggtttgtt ttctgctgac ttgctcggaa acccattgga ggtatctgaa atgtgatgac   5121

 tccaaagggg ttcatttcac tatagggaga aattgattcg tctgacttcc tatttatcac   5181

 cactcaatat tgggtgagtt ggtctgaaca aggtggggat aaagtagagt ggaaataatg   5241

 tagagtcgtc agactgaaag gccaggttgt agtcccagct cttatctgcc atcttggaca   5301

 aagcttttcc catctccagt ctcagtttcc catccataaa atgggggaag tggtaggtct   5361

 tgctgattgc atccacattc attcctccat ttcctttccc agcaaccccc catttctgtt   5421

 tgggaattca tatgatctgc cagagcctct ccaggggtgg aatacatgtc ctggactaag   5481

 ccaatgacac cttccatctt tccagctatg gtgactgggt taggtatgat cttgtgagtt   5541

 aagacaatga agccagaggg aatttcaaga cttatgggaa tgctgggtag aagctgtttt   5601

 aattcccctg ttgaatgtga aaaaggtagt agtattcctg ggtctttatg atgaccacct   5661

 tgggccttgg gatcatgacc aggaatcacg tgaagctgac accactgaag ggagagttga   5721

 gaggcagaaa gagatcaagt ccttggtgaa attgtttaag tacaggatca agccttgctt   5781

 gagattggcc ttacctctgg actttttttg ttatatgagc taataaattc tgtttattgt   5841

 ttaaaaaaaa aaa                                                      5854




      <210> 190
      <211> 3448
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(3370)

      <400> 190
 gagtcagagg taccaggtgg gtgtacatta cgaattgact gaggaagaga aattctatcg     60

 gaatgcttta acacgg    atg cct gat ggc cct gtt gcc ctg gaa gag tcg     109
                      Met Pro Asp Gly Pro Val Ala Leu Glu Glu Ser
                        1               5                  10

 tat tct gct gtc atg ggc att gta tct gaa gtt gaa cag tat gtc aag      157
 Tyr Ser Ala Val Met Gly Ile Val Ser Glu Val Glu Gln Tyr Val Lys
              15                  20                  25

 gtt tgg ctt cag tat cag tgt tta tgg gat atg caa gct gaa aac atc      205
 Val Trp Leu Gln Tyr Gln Cys Leu Trp Asp Met Gln Ala Glu Asn Ile
          30                  35                  40

 tat aac aga ctt gga gaa gat ctc aac aaa tgg cag gct ctc ctg gtc      253
 Tyr Asn Arg Leu Gly Glu Asp Leu Asn Lys Trp Gln Ala Leu Leu Val
      45                  50                  55

 caa ata agg aag gcc aga gga acc ttt gac aat gca gaa acc aag aaa      301
 Gln Ile Arg Lys Ala Arg Gly Thr Phe Asp Asn Ala Glu Thr Lys Lys
  60                  65                  70                  75

 gag ttt gga cca gta gtt ata gat tat ggc aag gta caa tct aag gtg      349
 Glu Phe Gly Pro Val Val Ile Asp Tyr Gly Lys Val Gln Ser Lys Val
                  80                  85                  90

 aac ttg aaa tat gac tct tgg cat aag gag gtt ctt agc aaa ttt ggg      397
 Asn Leu Lys Tyr Asp Ser Trp His Lys Glu Val Leu Ser Lys Phe Gly
              95                 100                 105

 cag atg cta gga tca aac atg acg gaa ttc cat tcc cag atc tca aag      445
 Gln Met Leu Gly Ser Asn Met Thr Glu Phe His Ser Gln Ile Ser Lys
         110                 115                 120

 tcc cgc caa gag ttg gag cag cac tca gta gac acg gcc agc acc tcc      493
 Ser Arg Gln Glu Leu Glu Gln His Ser Val Asp Thr Ala Ser Thr Ser
     125                 130                 135

 gat gca gtt acc ttc atc acc tat gtg cag tct ttg aaa cgg aag atc      541
 Asp Ala Val Thr Phe Ile Thr Tyr Val Gln Ser Leu Lys Arg Lys Ile
 140                 145                 150                 155

 aag cag ttt gag aag caa gtt gag ctc tac cgc aat ggc cag cgc tta      589
 Lys Gln Phe Glu Lys Gln Val Glu Leu Tyr Arg Asn Gly Gln Arg Leu
                 160                 165                 170

 ctg gaa aag caa agg ttc cag ttc cca cct tcc tgg ctt tat att gac      637
 Leu Glu Lys Gln Arg Phe Gln Phe Pro Pro Ser Trp Leu Tyr Ile Asp
             175                 180                 185

 aac atc gag gga gag tgg gga gcc ttc aat gac atc atg cgg cga aag      685
 Asn Ile Glu Gly Glu Trp Gly Ala Phe Asn Asp Ile Met Arg Arg Lys
         190                 195                 200

 gac tct gcc att cag cag cag gtg gca aac ctg caa atg aag att gtc      733
 Asp Ser Ala Ile Gln Gln Gln Val Ala Asn Leu Gln Met Lys Ile Val
     205                 210                 215

 cag gag gat cgg gcc gtg gaa agc cgc acc acc gac ctg ctg act gac      781
 Gln Glu Asp Arg Ala Val Glu Ser Arg Thr Thr Asp Leu Leu Thr Asp
 220                 225                 230                 235

 tgg gag aag acc aag cct gtc acg ggc aac ctt cgc cca gaa gag gca      829
 Trp Glu Lys Thr Lys Pro Val Thr Gly Asn Leu Arg Pro Glu Glu Ala
                 240                 245                 250

 ctt cag gct ctc acc ata tat gag ggg aag ttt ggt agg ctg aag gac      877
 Leu Gln Ala Leu Thr Ile Tyr Glu Gly Lys Phe Gly Arg Leu Lys Asp
             255                 260                 265

 gac aga gag aag tgt gca aag gcc aag gag gcg ctg gaa ttg aca gat      925
 Asp Arg Glu Lys Cys Ala Lys Ala Lys Glu Ala Leu Glu Leu Thr Asp
         270                 275                 280

 act ggg ctt ctc agt ggc agt gaa gag cgc gtg cag gtg gcc tta gaa      973
 Thr Gly Leu Leu Ser Gly Ser Glu Glu Arg Val Gln Val Ala Leu Glu
     285                 290                 295

 gaa tta cag gac ctc aaa ggc gtt tgg tca gaa ctt tct aag gtt tgg     1021
 Glu Leu Gln Asp Leu Lys Gly Val Trp Ser Glu Leu Ser Lys Val Trp
 300                 305                 310                 315

 gag caa atc gat cag atg aag gag caa ccc tgg gtt tca gta cag cct     1069
 Glu Gln Ile Asp Gln Met Lys Glu Gln Pro Trp Val Ser Val Gln Pro
                 320                 325                 330

 cga aag ctt cga caa aat ttg gat gcc ctc ctg aac cag ctg aaa agc     1117
 Arg Lys Leu Arg Gln Asn Leu Asp Ala Leu Leu Asn Gln Leu Lys Ser
             335                 340                 345

 ttc cct gcc cgg ttg cga cag tat gcg tcc tat gag ttt gtt cag agg     1165
 Phe Pro Ala Arg Leu Arg Gln Tyr Ala Ser Tyr Glu Phe Val Gln Arg
         350                 355                 360

 ctt ctg aaa ggt tac atg aag ata aat atg ctg gtg att gaa ctg aaa     1213
 Leu Leu Lys Gly Tyr Met Lys Ile Asn Met Leu Val Ile Glu Leu Lys
     365                 370                 375

 tcc gaa gca ctt aaa gac cgc cat tgg aaa cag ctc atg aaa agg ctt     1261
 Ser Glu Ala Leu Lys Asp Arg His Trp Lys Gln Leu Met Lys Arg Leu
 380                 385                 390                 395

 cac gtt aat tgg gtt gtt tct gag cta acc ctt ggc caa atc tgg gat     1309
 His Val Asn Trp Val Val Ser Glu Leu Thr Leu Gly Gln Ile Trp Asp
                 400                 405                 410

 gtt gac ttg cag aaa aat gaa gcg att gtc aag gat gta ctg ctt gtg     1357
 Val Asp Leu Gln Lys Asn Glu Ala Ile Val Lys Asp Val Leu Leu Val
             415                 420                 425

 gca caa ggg gag atg gct ttg gaa gaa ttt ttg aag cag ata aga gaa     1405
 Ala Gln Gly Glu Met Ala Leu Glu Glu Phe Leu Lys Gln Ile Arg Glu
         430                 435                 440

 gtg tgg aat act tat gaa cta gac ttg gtt aat tat cag aac aag tgc     1453
 Val Trp Asn Thr Tyr Glu Leu Asp Leu Val Asn Tyr Gln Asn Lys Cys
     445                 450                 455

 cgc ttg atc cgt ggc tgg gat gac ctc ttc aac aag gtc aaa gaa cac     1501
 Arg Leu Ile Arg Gly Trp Asp Asp Leu Phe Asn Lys Val Lys Glu His
 460                 465                 470                 475

 atc aac agc gtc tcg gcc atg aag ctc tct ccg tat tac aag gtt ttt     1549
 Ile Asn Ser Val Ser Ala Met Lys Leu Ser Pro Tyr Tyr Lys Val Phe
                 480                 485                 490

 gaa gag gat gct ctc agc tgg gaa gat aag ctg aac agg atc atg gct     1597
 Glu Glu Asp Ala Leu Ser Trp Glu Asp Lys Leu Asn Arg Ile Met Ala
             495                 500                 505

 ctc ttt gat gtg tgg att gat gtg cag agg cgg tgg gtc tac ctg gaa     1645
 Leu Phe Asp Val Trp Ile Asp Val Gln Arg Arg Trp Val Tyr Leu Glu
         510                 515                 520

 ggt atc ttc aca ggc agt gca gat atc aag cac ctg ctg cca gtg gaa     1693
 Gly Ile Phe Thr Gly Ser Ala Asp Ile Lys His Leu Leu Pro Val Glu
     525                 530                 535

 acc cag cgg ttt cag agc atc agc act gag ttt ttg gct cta atg aaa     1741
 Thr Gln Arg Phe Gln Ser Ile Ser Thr Glu Phe Leu Ala Leu Met Lys
 540                 545                 550                 555

 aaa gtg tcc aag tct ccc ctt gtt atg gat gtt ctg aac atc cag gga     1789
 Lys Val Ser Lys Ser Pro Leu Val Met Asp Val Leu Asn Ile Gln Gly
                 560                 565                 570

 gta cag agg tct ctg gaa aga ttg gca gac ctg cta gga aag atc cag     1837
 Val Gln Arg Ser Leu Glu Arg Leu Ala Asp Leu Leu Gly Lys Ile Gln
             575                 580                 585

 aaa gca ttg gga gaa tat ctg gaa aga gag cgg tca tct ttc ccc agg     1885
 Lys Ala Leu Gly Glu Tyr Leu Glu Arg Glu Arg Ser Ser Phe Pro Arg
         590                 595                 600

 ttc tat ttt gtg ggt gat gaa gat ttg ctt gaa atc att gga aac agc     1933
 Phe Tyr Phe Val Gly Asp Glu Asp Leu Leu Glu Ile Ile Gly Asn Ser
     605                 610                 615

 aag aat gtc gct aaa tta cag aaa cac ttc aag aag atg ttt gct gga     1981
 Lys Asn Val Ala Lys Leu Gln Lys His Phe Lys Lys Met Phe Ala Gly
 620                 625                 630                 635

 gtt tcg agc atc atc ctg aac gag gat aac tct gtt gtt ttg ggt att     2029
 Val Ser Ser Ile Ile Leu Asn Glu Asp Asn Ser Val Val Leu Gly Ile
                 640                 645                 650

 tca tct cgg gaa gga gag gag gtt atg ttt aaa act cct gtg tca att     2077
 Ser Ser Arg Glu Gly Glu Glu Val Met Phe Lys Thr Pro Val Ser Ile
             655                 660                 665

 act gaa cat ccc aaa atc aat gag tgg ctc aca ttg gta gaa aag gag     2125
 Thr Glu His Pro Lys Ile Asn Glu Trp Leu Thr Leu Val Glu Lys Glu
         670                 675                 680

 atg aga gtc acc ctg gcc aaa ctg ctt gct gag tct gtt acg gaa gtt     2173
 Met Arg Val Thr Leu Ala Lys Leu Leu Ala Glu Ser Val Thr Glu Val
     685                 690                 695

 gag att ttt ggt aaa gca act tca att gac cca aat acc tac atc act     2221
 Glu Ile Phe Gly Lys Ala Thr Ser Ile Asp Pro Asn Thr Tyr Ile Thr
 700                 705                 710                 715

 tgg att gat aaa tac cag gcc cag ctt gtg gtt ttg tca gcc cag ata     2269
 Trp Ile Asp Lys Tyr Gln Ala Gln Leu Val Val Leu Ser Ala Gln Ile
                 720                 725                 730

 gcc tgg tct gag aac gtg gag acc gca ctg agc agc atg ggc gga ggt     2317
 Ala Trp Ser Glu Asn Val Glu Thr Ala Leu Ser Ser Met Gly Gly Gly
             735                 740                 745

 gga gat gcc gcg ccc ttg cac tct gtg ctg agc aat gtg gag gtc acc     2365
 Gly Asp Ala Ala Pro Leu His Ser Val Leu Ser Asn Val Glu Val Thr
         750                 755                 760

 ctc aat gtg tta gca gac tct gtc ctc atg gag cag ccc cca ctc cga     2413
 Leu Asn Val Leu Ala Asp Ser Val Leu Met Glu Gln Pro Pro Leu Arg
     765                 770                 775

 agg cgg aag cta gaa cac ttg att aca gag ttg gtt cac cag aga gat     2461
 Arg Arg Lys Leu Glu His Leu Ile Thr Glu Leu Val His Gln Arg Asp
 780                 785                 790                 795

 gtt aca agg tcc ttg atc aaa agc aag att gac aac gcc aaa tct ttt     2509
 Val Thr Arg Ser Leu Ile Lys Ser Lys Ile Asp Asn Ala Lys Ser Phe
                 800                 805                 810

 gaa tgg ctc agc cag atg cga ttt tac ttt gac cct aag caa act gat     2557
 Glu Trp Leu Ser Gln Met Arg Phe Tyr Phe Asp Pro Lys Gln Thr Asp
             815                 820                 825

 gtg tta cag cag ttg tca att caa atg gca aat gcc aaa ttt aac tat     2605
 Val Leu Gln Gln Leu Ser Ile Gln Met Ala Asn Ala Lys Phe Asn Tyr
         830                 835                 840

 ggc ttt gag tac ctg ggt gtt cag gac aaa ctg gtc cag acc ccc ctc     2653
 Gly Phe Glu Tyr Leu Gly Val Gln Asp Lys Leu Val Gln Thr Pro Leu
     845                 850                 855

 act gac cgc tgc tat ttg aca atg aca caa gcc ttg gag gcc agg ctg     2701
 Thr Asp Arg Cys Tyr Leu Thr Met Thr Gln Ala Leu Glu Ala Arg Leu
 860                 865                 870                 875

 ggg ggt tcc cca ttt gga cct gct gga act ggg aaa aca gag tct gtc     2749
 Gly Gly Ser Pro Phe Gly Pro Ala Gly Thr Gly Lys Thr Glu Ser Val
                 880                 885                 890

 aaa gct ctt ggc cat cag ctt gga cgg ttt gtt tta gtt ttc aac tgt     2797
 Lys Ala Leu Gly His Gln Leu Gly Arg Phe Val Leu Val Phe Asn Cys
             895                 900                 905

 gat gaa acc ttt gat ttc cag gca atg ggc cgg atc ttt gtg ggc ctt     2845
 Asp Glu Thr Phe Asp Phe Gln Ala Met Gly Arg Ile Phe Val Gly Leu
         910                 915                 920

 tgc cag gtg ggt gcc tgg ggc tgc ttt gac gag ttc aac cgc ctg gag     2893
 Cys Gln Val Gly Ala Trp Gly Cys Phe Asp Glu Phe Asn Arg Leu Glu
     925                 930                 935

 gag cgg atg ctc tcg gct gtg tcc cag cag gtg cag tgc ata cag gaa     2941
 Glu Arg Met Leu Ser Ala Val Ser Gln Gln Val Gln Cys Ile Gln Glu
 940                 945                 950                 955

 gca ctg cgt gaa cat tcc aac ccc aac tac gac aag acc tct gcc ccc     2989
 Ala Leu Arg Glu His Ser Asn Pro Asn Tyr Asp Lys Thr Ser Ala Pro
                 960                 965                 970

 att act tgt gag ctg ctg aac aaa caa gtc aag gtg agc ccg gac atg     3037
 Ile Thr Cys Glu Leu Leu Asn Lys Gln Val Lys Val Ser Pro Asp Met
             975                 980                 985

 gcc atc ttc atc acc atg aac cct ggc tac gcg ggc cgg tct aac ctt     3085
 Ala Ile Phe Ile Thr Met Asn Pro Gly Tyr Ala Gly Arg Ser Asn Leu
         990                 995                1000

 cct gac aac ttg aag aag ctg ttc cgg agc ttg gcc atg acc aag ccc     3133
 Pro Asp Asn Leu Lys Lys Leu Phe Arg Ser Leu Ala Met Thr Lys Pro
    1005                1010                1015

 gac cgg cag tta atc gcc cag gtc atg ctg tac tca cag ggt ttc cgc     3181
 Asp Arg Gln Leu Ile Ala Gln Val Met Leu Tyr Ser Gln Gly Phe Arg
1020                1025                1030                1035

 act gct gaa gtg ctt gcc aac aaa atc gtc ctg ttt ttt aaa cta tgc     3229
 Thr Ala Glu Val Leu Ala Asn Lys Ile Val Leu Phe Phe Lys Leu Cys
                1040                1045                1050

 gat gag cag ctc tct tcc caa agc cat tat gac ttc ggt ctt cgg gct     3277
 Asp Glu Gln Leu Ser Ser Gln Ser His Tyr Asp Phe Gly Leu Arg Ala
            1055                1060                1065

 ttg aag agt gtg ctg gtg agt gca ggc aat gtg aag aga gag aga atc     3325
 Leu Lys Ser Val Leu Val Ser Ala Gly Asn Val Lys Arg Glu Arg Ile
        1070                1075                1080

 cag aag ata aag agg gag aaa gag gaa cga ggg gaa gaa aat tga caa     3373
 Gln Lys Ile Lys Arg Glu Lys Glu Glu Arg Gly Glu Glu Asn 
    1085                1090                1095

 atacacagag gtcctcaaga cccacggact cctggtctga gcccaataaa gactgttaat   3433

 tcctaaaaaa aaaaa                                                    3448




      <210> 191
      <211> 4477
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(4407)

      <400> 191
 aatggaagag cgactagcaa agtttatttc ctccaacact ccgacagcgt gctgcccttg     60

 gcagatggag ccctgagctt tattcatcat caggtgattg ag   atg gcc cga gac     114
                                                  Met Ala Arg Asp
                                                    1

 tgc ctg gat aaa tct cgg agt ggc ctc att aca tca caa tac ttc tac      162
 Cys Leu Asp Lys Ser Arg Ser Gly Leu Ile Thr Ser Gln Tyr Phe Tyr
   5                  10                  15                  20

 gaa ctt caa gag aat ttg gag aaa ctt tta caa gat gct cat gag cgc      210
 Glu Leu Gln Glu Asn Leu Glu Lys Leu Leu Gln Asp Ala His Glu Arg
                  25                  30                  35

 tca gag agc tca gaa gtg gct ttt gtg atg cag ctg gtg aaa aag ctg      258
 Ser Glu Ser Ser Glu Val Ala Phe Val Met Gln Leu Val Lys Lys Leu
              40                  45                  50

 atg att atc att gcc cgc cca gca cgt ctc ctg gaa tgc ctg gag ttt      306
 Met Ile Ile Ile Ala Arg Pro Ala Arg Leu Leu Glu Cys Leu Glu Phe
          55                  60                  65

 gac cct gaa gag ttc tac cac ctt tta gaa gca gct gag ggc cac gcc      354
 Asp Pro Glu Glu Phe Tyr His Leu Leu Glu Ala Ala Glu Gly His Ala
      70                  75                  80

 aaa gag gga caa ggg att aaa tgt gac att ccc cgc tac atc gtt agc      402
 Lys Glu Gly Gln Gly Ile Lys Cys Asp Ile Pro Arg Tyr Ile Val Ser
  85                  90                  95                 100

 cag ctg ggc ctc acc cgg gat ccc cta gaa gaa atg gcc cag ttg agc      450
 Gln Leu Gly Leu Thr Arg Asp Pro Leu Glu Glu Met Ala Gln Leu Ser
                 105                 110                 115

 agc tgt gac agt cct gac act cca gag aca gat gat tct att gag ggc      498
 Ser Cys Asp Ser Pro Asp Thr Pro Glu Thr Asp Asp Ser Ile Glu Gly
             120                 125                 130

 cat ggg gca tct ctg cca tct aaa aag aca ccc tct gaa gag gac ttc      546
 His Gly Ala Ser Leu Pro Ser Lys Lys Thr Pro Ser Glu Glu Asp Phe
         135                 140                 145

 gag acc att aag ctc atc agc aat ggc gcc tat ggg gct gta ttt ctg      594
 Glu Thr Ile Lys Leu Ile Ser Asn Gly Ala Tyr Gly Ala Val Phe Leu
     150                 155                 160

 gtg cgg cac aag tcc acc cgg cag cgc ttt gcc atg aag aag atc aac      642
 Val Arg His Lys Ser Thr Arg Gln Arg Phe Ala Met Lys Lys Ile Asn
 165                 170                 175                 180

 aag cag aac ctg atc cta cgg aac cag atc cag cag gcc ttc gtg gag      690
 Lys Gln Asn Leu Ile Leu Arg Asn Gln Ile Gln Gln Ala Phe Val Glu
                 185                 190                 195

 cgt gac ata ctg act ttc gct gag aac ccc ttt gtg gtc agc atg ttc      738
 Arg Asp Ile Leu Thr Phe Ala Glu Asn Pro Phe Val Val Ser Met Phe
             200                 205                 210

 tgc tcc ttt gat acc aag cgc cac ttg tgc atg gtg atg gag tac gtt      786
 Cys Ser Phe Asp Thr Lys Arg His Leu Cys Met Val Met Glu Tyr Val
         215                 220                 225

 gaa ggg gga gac tgt gcc act ctg ctg aag aat att ggg gcc ctg cct      834
 Glu Gly Gly Asp Cys Ala Thr Leu Leu Lys Asn Ile Gly Ala Leu Pro
     230                 235                 240

 gtg gac atg gtg cgt cta tac ttt gcg gaa act gtg ctg gcc ctg gag      882
 Val Asp Met Val Arg Leu Tyr Phe Ala Glu Thr Val Leu Ala Leu Glu
 245                 250                 255                 260

 tac tta cac aac tat ggc atc gtg cac cgt gac ctc aag cct gac aac      930
 Tyr Leu His Asn Tyr Gly Ile Val His Arg Asp Leu Lys Pro Asp Asn
                 265                 270                 275

 ctc cta att aca tcc atg ggg cac atc aag ctc acg gac ttt gga ctg      978
 Leu Leu Ile Thr Ser Met Gly His Ile Lys Leu Thr Asp Phe Gly Leu
             280                 285                 290

 tcc aaa atg ggc ctc atg agt ctg aca acg aac ttg tat gag ggt cat     1026
 Ser Lys Met Gly Leu Met Ser Leu Thr Thr Asn Leu Tyr Glu Gly His
         295                 300                 305

 att gaa aag gat gcc cgg gaa ttc ctg gac aag cag gta tgc ggg acc     1074
 Ile Glu Lys Asp Ala Arg Glu Phe Leu Asp Lys Gln Val Cys Gly Thr
     310                 315                 320

 cca gaa tac att gcg cct gag gtg atc ctg cgc cag ggc tat ggg aag     1122
 Pro Glu Tyr Ile Ala Pro Glu Val Ile Leu Arg Gln Gly Tyr Gly Lys
 325                 330                 335                 340

 cca gtg gac tgg tgg gcc atg ggc att atc ctg tat gag ttc ctg gtg     1170
 Pro Val Asp Trp Trp Ala Met Gly Ile Ile Leu Tyr Glu Phe Leu Val
                 345                 350                 355

 ggc tgc gtc cct ttt ttt gga gat act ccg gag gag ctc ttt ggg cag     1218
 Gly Cys Val Pro Phe Phe Gly Asp Thr Pro Glu Glu Leu Phe Gly Gln
             360                 365                 370

 gtg atc agt gat gag att gtg tgg cct gag ggt gat gag gca ctg ccc     1266
 Val Ile Ser Asp Glu Ile Val Trp Pro Glu Gly Asp Glu Ala Leu Pro
         375                 380                 385

 cca gac gcc cag gac ctc acc tcc aaa ctg ctc cac cag aac cct ctg     1314
 Pro Asp Ala Gln Asp Leu Thr Ser Lys Leu Leu His Gln Asn Pro Leu
     390                 395                 400

 gag aga ctt ggc aca ggc agt gcc tat gag gtg aag cag cac cca ttc     1362
 Glu Arg Leu Gly Thr Gly Ser Ala Tyr Glu Val Lys Gln His Pro Phe
 405                 410                 415                 420

 ttt act ggt ctg gac tgg aca gga ctt ctc cgc cag aag gct gaa ttt     1410
 Phe Thr Gly Leu Asp Trp Thr Gly Leu Leu Arg Gln Lys Ala Glu Phe
                 425                 430                 435

 att cct cag ttg gag tca gag gat gat act agc tat ttt gac acc cgc     1458
 Ile Pro Gln Leu Glu Ser Glu Asp Asp Thr Ser Tyr Phe Asp Thr Arg
             440                 445                 450

 tca gag cga tac cac cac atg gac tcg gag gat gag gaa gaa gtg agt     1506
 Ser Glu Arg Tyr His His Met Asp Ser Glu Asp Glu Glu Glu Val Ser
         455                 460                 465

 gag gat ggc tgc ctt gag atc cgc cag ttc tct tcc tgc tct cca agg     1554
 Glu Asp Gly Cys Leu Glu Ile Arg Gln Phe Ser Ser Cys Ser Pro Arg
     470                 475                 480

 ttc aac aag gtg tac agc agc atg gag cgg ctc tca ctg ctc gag gag     1602
 Phe Asn Lys Val Tyr Ser Ser Met Glu Arg Leu Ser Leu Leu Glu Glu
 485                 490                 495                 500

 cgc cgg aca cca ccc ccg acc aag cgc agc ctg agt gag gag aag gag     1650
 Arg Arg Thr Pro Pro Pro Thr Lys Arg Ser Leu Ser Glu Glu Lys Glu
                 505                 510                 515

 gac cat tca gat ggc ctg gca ggg ctc aaa ggc cga gac cgg agc tgg     1698
 Asp His Ser Asp Gly Leu Ala Gly Leu Lys Gly Arg Asp Arg Ser Trp
             520                 525                 530

 gtg att ggc tcc cct gag ata tta cgg aag cgg ctg tcg gtg tct gag     1746
 Val Ile Gly Ser Pro Glu Ile Leu Arg Lys Arg Leu Ser Val Ser Glu
         535                 540                 545

 tcg tcc cac aca gag agt gac tca agc cct cca atg aca gtg cga cgc     1794
 Ser Ser His Thr Glu Ser Asp Ser Ser Pro Pro Met Thr Val Arg Arg
     550                 555                 560

 cgc tgc tca ggc ctc ctg gat gcg cct cgg ttc ccg gag ggc cct gag     1842
 Arg Cys Ser Gly Leu Leu Asp Ala Pro Arg Phe Pro Glu Gly Pro Glu
 565                 570                 575                 580

 gag gcc agc agc acc ctc agg agg caa cca cag gag ggt ata tgg gtc     1890
 Glu Ala Ser Ser Thr Leu Arg Arg Gln Pro Gln Glu Gly Ile Trp Val
                 585                 590                 595

 ctg aca ccc cca tct gga gag ggg gta tct ggg cct gtc act gaa cac     1938
 Leu Thr Pro Pro Ser Gly Glu Gly Val Ser Gly Pro Val Thr Glu His
             600                 605                 610

 tca ggg gag cag cgg cca aag ctg gat gag gaa gct gtt ggc cgg agc     1986
 Ser Gly Glu Gln Arg Pro Lys Leu Asp Glu Glu Ala Val Gly Arg Ser
         615                 620                 625

 agt ggt tcc agt cca gct atg gag acc cga ggc cgt ggg acc tca cag     2034
 Ser Gly Ser Ser Pro Ala Met Glu Thr Arg Gly Arg Gly Thr Ser Gln
     630                 635                 640

 ctg gct gag gga gcc aca gcc aag gcc atc agt gac ctg gct gtg cgt     2082
 Leu Ala Glu Gly Ala Thr Ala Lys Ala Ile Ser Asp Leu Ala Val Arg
 645                 650                 655                 660

 agg gcc cgc cac cgg ctg ctc tct ggg gac tca aca gag aag cgc act     2130
 Arg Ala Arg His Arg Leu Leu Ser Gly Asp Ser Thr Glu Lys Arg Thr
                 665                 670                 675

 gct cgc cct gtc aac aaa gtg atc aag tcc gtc tca gcc aca gcc ctc     2178
 Ala Arg Pro Val Asn Lys Val Ile Lys Ser Val Ser Ala Thr Ala Leu
             680                 685                 690

 tca ctc ctc att cct tcg gaa cac cac acc tgc tcc ccg ttg gcc agc     2226
 Ser Leu Leu Ile Pro Ser Glu His His Thr Cys Ser Pro Leu Ala Ser
         695                 700                 705

 ccc atg tcc cca cat tct cag tcg tcc aac cca tca tcc cgg gac tct     2274
 Pro Met Ser Pro His Ser Gln Ser Ser Asn Pro Ser Ser Arg Asp Ser
     710                 715                 720

 tct cca agc agg gac ttc ttg cca gcc ctt ggc agc atg agg cct ccc     2322
 Ser Pro Ser Arg Asp Phe Leu Pro Ala Leu Gly Ser Met Arg Pro Pro
 725                 730                 735                 740

 atc atc atc cac cga gct ggc aag aag tat ggc ttc acc ctg cgg gcc     2370
 Ile Ile Ile His Arg Ala Gly Lys Lys Tyr Gly Phe Thr Leu Arg Ala
                 745                 750                 755

 att cgc gtc tac atg ggt gac tcc gat gtc tac acc gtg cac cat atg     2418
 Ile Arg Val Tyr Met Gly Asp Ser Asp Val Tyr Thr Val His His Met
             760                 765                 770

 gtg tgg cac gtg gag gat gga ggt ccg gcc agt gag gca ggg ctt cgt     2466
 Val Trp His Val Glu Asp Gly Gly Pro Ala Ser Glu Ala Gly Leu Arg
         775                 780                 785

 caa ggt gac ctc atc acc cat gtc aat ggg gaa cct gtg cat ggc ctg     2514
 Gln Gly Asp Leu Ile Thr His Val Asn Gly Glu Pro Val His Gly Leu
     790                 795                 800

 gtg cac acg gag gtg gtg gag ctg atc ctg aag agt gga aac aag gtg     2562
 Val His Thr Glu Val Val Glu Leu Ile Leu Lys Ser Gly Asn Lys Val
 805                 810                 815                 820

 gcc att tca aca act ccc ctg gag aac aca tcc att aaa gtg ggg cca     2610
 Ala Ile Ser Thr Thr Pro Leu Glu Asn Thr Ser Ile Lys Val Gly Pro
                 825                 830                 835

 gct cgg aag ggc agc tac aag gcc aag atg gcc cga agg agc aag agg     2658
 Ala Arg Lys Gly Ser Tyr Lys Ala Lys Met Ala Arg Arg Ser Lys Arg
             840                 845                 850

 agc cgc ggc aag gat ggg caa gaa agc aga aaa agg agc tcc ctg ttc     2706
 Ser Arg Gly Lys Asp Gly Gln Glu Ser Arg Lys Arg Ser Ser Leu Phe
         855                 860                 865

 cgc aag atc acc aag caa gca tcc ctg ctc cac acc agc cgc agc ctt     2754
 Arg Lys Ile Thr Lys Gln Ala Ser Leu Leu His Thr Ser Arg Ser Leu
     870                 875                 880

 tct tcc ctt aac cgc tcc ttg tca tca ggg gag agt ggg cca ggc tct     2802
 Ser Ser Leu Asn Arg Ser Leu Ser Ser Gly Glu Ser Gly Pro Gly Ser
 885                 890                 895                 900

 ccc aca cac agc cac agc ctt tcc ccc cga tct ccc act caa ggc tac     2850
 Pro Thr His Ser His Ser Leu Ser Pro Arg Ser Pro Thr Gln Gly Tyr
                 905                 910                 915

 cgg gtg acc ccc gat gct gtg cat tca gtg gga ggg aat tca tca cag     2898
 Arg Val Thr Pro Asp Ala Val His Ser Val Gly Gly Asn Ser Ser Gln
             920                 925                 930

 agc agc tcc ccc agc tcc agc gtg ccc agt tcc cca gcc ggc tct ggg     2946
 Ser Ser Ser Pro Ser Ser Ser Val Pro Ser Ser Pro Ala Gly Ser Gly
         935                 940                 945

 cac aca cgg ccc agc tcc ctc cac ggt ctg gca ccc aag ctc caa cgc     2994
 His Thr Arg Pro Ser Ser Leu His Gly Leu Ala Pro Lys Leu Gln Arg
     950                 955                 960

 cag tac cgc tct cca cgg cgc aag tca gca ggc agc atc cca ctg tca     3042
 Gln Tyr Arg Ser Pro Arg Arg Lys Ser Ala Gly Ser Ile Pro Leu Ser
 965                 970                 975                 980

 cca ctg gcc cac acc cct tct ccc cca ccc cca aca gct tca cct cag     3090
 Pro Leu Ala His Thr Pro Ser Pro Pro Pro Pro Thr Ala Ser Pro Gln
                 985                 990                 995

 cgg tcc cca tcg ccc ctg tct ggc cat gta gcc cag gcc ttt ccc aca     3138
 Arg Ser Pro Ser Pro Leu Ser Gly His Val Ala Gln Ala Phe Pro Thr
            1000                1005                1010

 aag ctt cac ttg tca cct ccc ctg ggc agg caa ctc tca cgg ccc aag     3186
 Lys Leu His Leu Ser Pro Pro Leu Gly Arg Gln Leu Ser Arg Pro Lys
        1015                1020                1025

 agt gcg gag cca ccc cgt tca cca cta ctc aag agg gtg cag tcg gct     3234
 Ser Ala Glu Pro Pro Arg Ser Pro Leu Leu Lys Arg Val Gln Ser Ala
    1030                1035                1040

 gag aaa ctg gca gca gca ctt gcc gcc tct gag aag aag cta gcc act     3282
 Glu Lys Leu Ala Ala Ala Leu Ala Ala Ser Glu Lys Lys Leu Ala Thr
1045                1050                1055                1060

 tct cgc aag cac agc ctt gac ctg ccc cac tct gaa cta aag aag gaa     3330
 Ser Arg Lys His Ser Leu Asp Leu Pro His Ser Glu Leu Lys Lys Glu
                1065                1070                1075

 ctg ccg ccc agg gaa gtg agc cct ctg gag gta gtt gga gcc agg agt     3378
 Leu Pro Pro Arg Glu Val Ser Pro Leu Glu Val Val Gly Ala Arg Ser
            1080                1085                1090

 gtg ctg tct ggc aag ggg gcc ctg cca ggg aag ggg gtg ctg cag cct     3426
 Val Leu Ser Gly Lys Gly Ala Leu Pro Gly Lys Gly Val Leu Gln Pro
        1095                1100                1105

 gct ccc tca cgg gcc cta ggc acc ctc cgg cag gac cga gcc gaa cga     3474
 Ala Pro Ser Arg Ala Leu Gly Thr Leu Arg Gln Asp Arg Ala Glu Arg
    1110                1115                1120

 cgg gag tcg ctg cag aag caa gaa gcc att cgt gag gtg gac tcc tca     3522
 Arg Glu Ser Leu Gln Lys Gln Glu Ala Ile Arg Glu Val Asp Ser Ser
1125                1130                1135                1140

 gag gac gac acc gag gaa ggg cct gag aac agc cag ggt gca cag gag     3570
 Glu Asp Asp Thr Glu Glu Gly Pro Glu Asn Ser Gln Gly Ala Gln Glu
                1145                1150                1155

 ctg agc ttg gca cct cac cca gaa gtg agc cag agt gtg gcc cct aaa     3618
 Leu Ser Leu Ala Pro His Pro Glu Val Ser Gln Ser Val Ala Pro Lys
            1160                1165                1170

 gga gca gga gag agt ggg gaa gag gat cct ttc ccg tcc aga gac cct     3666
 Gly Ala Gly Glu Ser Gly Glu Glu Asp Pro Phe Pro Ser Arg Asp Pro
        1175                1180                1185

 agg agc ctg ggc cca atg gtc cca agc cta ttg aca ggg atc aca ctg     3714
 Arg Ser Leu Gly Pro Met Val Pro Ser Leu Leu Thr Gly Ile Thr Leu
    1190                1195                1200

 ggg cct ccc aga atg gaa agt ccc agt ggt ccc cac agg agg ctc ggg     3762
 Gly Pro Pro Arg Met Glu Ser Pro Ser Gly Pro His Arg Arg Leu Gly
1205                1210                1215                1220

 agc cca caa gcc att gag gag gct gcc agc tcc tcc tca gca ggc ccc     3810
 Ser Pro Gln Ala Ile Glu Glu Ala Ala Ser Ser Ser Ser Ala Gly Pro
                1225                1230                1235

 aac cta ggt cag tct gga gcc aca gac ccc atc cct cct gaa ggt tgc     3858
 Asn Leu Gly Gln Ser Gly Ala Thr Asp Pro Ile Pro Pro Glu Gly Cys
            1240                1245                1250

 tgg aag gcc cag cac ctc cac acc cag gca cta aca gca ctt tct ccc     3906
 Trp Lys Ala Gln His Leu His Thr Gln Ala Leu Thr Ala Leu Ser Pro
        1255                1260                1265

 agc act tcg gga ctc acc ccc acc agc agt tgc tct cct ccc agc tcc     3954
 Ser Thr Ser Gly Leu Thr Pro Thr Ser Ser Cys Ser Pro Pro Ser Ser
    1270                1275                1280

 acc tct ggg aag ctg agc atg tgg tcc tgg aaa tcc ctt att gag ggc     4002
 Thr Ser Gly Lys Leu Ser Met Trp Ser Trp Lys Ser Leu Ile Glu Gly
1285                1290                1295                1300

 cca gac agg gca tcc cca agc aga aag gca acc atg gca ggt ggg cta     4050
 Pro Asp Arg Ala Ser Pro Ser Arg Lys Ala Thr Met Ala Gly Gly Leu
                1305                1310                1315

 gcc aac ctc cag gat ttg gaa aac aca act cca gcc cag cct aag aac     4098
 Ala Asn Leu Gln Asp Leu Glu Asn Thr Thr Pro Ala Gln Pro Lys Asn
            1320                1325                1330

 ctg tct ccc agg gag cag ggg aag aca cag cca cct agt gcc ccc aga     4146
 Leu Ser Pro Arg Glu Gln Gly Lys Thr Gln Pro Pro Ser Ala Pro Arg
        1335                1340                1345

 ctg gcc cat cca tct tat gag gat ccc agc cag ggc tgg cta tgg gag     4194
 Leu Ala His Pro Ser Tyr Glu Asp Pro Ser Gln Gly Trp Leu Trp Glu
    1350                1355                1360

 tct gag tgt gca caa gca gtg aaa gag gat cca gcc ctg agc atc acc     4242
 Ser Glu Cys Ala Gln Ala Val Lys Glu Asp Pro Ala Leu Ser Ile Thr
1365                1370                1375                1380

 caa gtg cct gat gcc tca ggt gac aga agg cag gac gtt cca tgc cga     4290
 Gln Val Pro Asp Ala Ser Gly Asp Arg Arg Gln Asp Val Pro Cys Arg
                1385                1390                1395

 ggc tgc ccc ctc acc cag aag tct gag ccc agc ctc agg agg ggc caa     4338
 Gly Cys Pro Leu Thr Gln Lys Ser Glu Pro Ser Leu Arg Arg Gly Gln
            1400                1405                1410

 gaa cca ggg ggc cat caa aag cat cgg gat ttg gca ttg gtt cca gat     4386
 Glu Pro Gly Gly His Gln Lys His Arg Asp Leu Ala Leu Val Pro Asp
        1415                1420                1425

 gag ctt tta aag caa aca tag ca gttgtttgcc atttcttgca ctcagacctg     4439
 Glu Leu Leu Lys Gln Thr 
    1430

 tgtaatatat gctcctggaa accatcaaaa aaaaaaaa                           4477




      <210> 192
      <211> 1688
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (73)..(1062)

      <400> 192
 cgtcctcgct gctcacattt cggcggaggg cgcgctccct ggaaaattcc actcctgtgc     60

 tagctccacc ct    atg cgg ctt ttc tcc tac ccg acg ctc ttc act ctc     108
                  Met Arg Leu Phe Ser Tyr Pro Thr Leu Phe Thr Leu
                    1               5                  10

 agc tcc ctt ccc ggc ggc ctt tgc ggg aac aag atg gca gcc ccc ata      156
 Ser Ser Leu Pro Gly Gly Leu Cys Gly Asn Lys Met Ala Ala Pro Ile
          15                  20                  25

 cct caa ggg ttc tct tgt tta tcg agg ttt ttg ggc tgg tgg tct cgg      204
 Pro Gln Gly Phe Ser Cys Leu Ser Arg Phe Leu Gly Trp Trp Ser Arg
      30                  35                  40

 cag cca gtt ctg gtg act cag tcc gca gct ata gtt cca gta aga act      252
 Gln Pro Val Leu Val Thr Gln Ser Ala Ala Ile Val Pro Val Arg Thr
  45                  50                  55                  60

 aaa aaa cgt ttc aca cct cct att tat caa cct aaa ttt aaa aca gaa      300
 Lys Lys Arg Phe Thr Pro Pro Ile Tyr Gln Pro Lys Phe Lys Thr Glu
                  65                  70                  75

 aag gag ttt atg caa cat gcc cgg aaa gca gga ttg gtt att cct cca      348
 Lys Glu Phe Met Gln His Ala Arg Lys Ala Gly Leu Val Ile Pro Pro
              80                  85                  90

 gaa aaa tcg gac cgt tcc ata cat ctg gcc tgt aca gct ggt ata ttt      396
 Glu Lys Ser Asp Arg Ser Ile His Leu Ala Cys Thr Ala Gly Ile Phe
          95                 100                 105

 gat gcc tat gtt cct cct gag ggt gat gca cgc ata tca tct ctt tca      444
 Asp Ala Tyr Val Pro Pro Glu Gly Asp Ala Arg Ile Ser Ser Leu Ser
     110                 115                 120

 aag gag gga ctg ata gag aga act gaa cga atg aag aag act atg gca      492
 Lys Glu Gly Leu Ile Glu Arg Thr Glu Arg Met Lys Lys Thr Met Ala
 125                 130                 135                 140

 tca caa gtg tca atc cgg agg ata aaa gac tat gat gcc aac ttt aaa      540
 Ser Gln Val Ser Ile Arg Arg Ile Lys Asp Tyr Asp Ala Asn Phe Lys
                 145                 150                 155

 ata aag gac ttc cct gaa aaa gct aag gat atc ttt att gaa gct cac      588
 Ile Lys Asp Phe Pro Glu Lys Ala Lys Asp Ile Phe Ile Glu Ala His
             160                 165                 170

 ctt tgt cta aat aac tca gac cat gac cga ctt cat acc ttg gta act      636
 Leu Cys Leu Asn Asn Ser Asp His Asp Arg Leu His Thr Leu Val Thr
         175                 180                 185

 gaa cac tgt ttt cca gac atg act tgg gac atc aaa tat aag acc gtc      684
 Glu His Cys Phe Pro Asp Met Thr Trp Asp Ile Lys Tyr Lys Thr Val
     190                 195                 200

 cgc tgg agc ttt gtg gaa tct tta gag ccc tct cat gtt gtt caa gtt      732
 Arg Trp Ser Phe Val Glu Ser Leu Glu Pro Ser His Val Val Gln Val
 205                 210                 215                 220

 cgc tgt tca agt atg atg aac cag ggc aac gtg tac ggc cag atc acc      780
 Arg Cys Ser Ser Met Met Asn Gln Gly Asn Val Tyr Gly Gln Ile Thr
                 225                 230                 235

 gta cgc atg cac acc cgg cag act ctg gcc atc tat gac cgg ttt ggc      828
 Val Arg Met His Thr Arg Gln Thr Leu Ala Ile Tyr Asp Arg Phe Gly
             240                 245                 250

 cgg ttg atg tat gga cag gaa gat gta ccc aag gat gtc ctg gag tat      876
 Arg Leu Met Tyr Gly Gln Glu Asp Val Pro Lys Asp Val Leu Glu Tyr
         255                 260                 265

 gtt gta ttc gaa aag cag ttg aca aac ccc tat gga agc tgg aga atg      924
 Val Val Phe Glu Lys Gln Leu Thr Asn Pro Tyr Gly Ser Trp Arg Met
     270                 275                 280

 cat acc aag atc gtt ccc cca tgg gca ccc cct aag cag ccc atc ctt      972
 His Thr Lys Ile Val Pro Pro Trp Ala Pro Pro Lys Gln Pro Ile Leu
 285                 290                 295                 300

 aag acg gtg atg atc cct ggc cct cag ctg aaa cca gaa gaa gaa tat     1020
 Lys Thr Val Met Ile Pro Gly Pro Gln Leu Lys Pro Glu Glu Glu Tyr
                 305                 310                 315

 gaa gag gca caa gga gag gcc cag aag cct cag cta gcc tga tgacaaa     1069
 Glu Glu Ala Gln Gly Glu Ala Gln Lys Pro Gln Leu Ala 
             320                 325

 aatgacttct agggtgaagc ctgggtgatg aggctgctgg aagctttgaa gtctcccatt   1129

 cccctcatgc tataaaaaga actacctttg ttctctccca tcctgctcag gtcttttcag   1189

 cagtctcatc atcagcaacc atgactgatg actgggccct agcaggtggc aggtataaca   1249

 tggccatgga cactcttctt ttttaaattt tatgtctagc ttctgagtct agatgaaaga   1309

 cagtatgttt cagagaacat tggatatcag tttttcccac agcagggact gtgagagaca   1369

 accagcagca tcctctttgt aatcacaggg cagggatcag agtttgaaat gaaatgttgt   1429

 cagggtgttg gaaaaatttt ggtgagttct gcacatttcc cctggttcag gctgggcatg   1489

 gaccagcctt cagatggcag aagtggaaga tgagcctact tgtgagcgat gtgactttaa   1549

 ggaaatgaag actggggaag aataattagt gtttataaga catttaagag gccctttttc   1609

 atatactgac tcactgatga atcagcattt gcattttatg gaaaaatata aatccaaaga   1669

 aataatttaa aaaaaaaaa                                                1688




      <210> 193
      <211> 570
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (265)..(501)

      <400> 193
 gatgaggagc caacaaaaaa gagcctcagg atccagcaca cattatcaca aacttagtgt     60

 ccatccatca ctgctgaccc tctccggacc tgactccacc cctgcaggga cacaggtcag    120

 ccttgaccaa tgacttttaa gtaccatgga gaacaggggg ccagaacttc ggcagtaaag    180

 aataaaaggc cagacagaga ggcagcagca catatctgct tccgacacag ctgcaatcac    240

 tagcaagctc tcaggcctgg catc   atg gtg cat ttt act gct gag gag aag     291
                              Met Val His Phe Thr Ala Glu Glu Lys
                                1               5

 gct gcc gtc act agc ctg tgg agc aag atg aat gtg gaa gag gct gga      339
 Ala Ala Val Thr Ser Leu Trp Ser Lys Met Asn Val Glu Glu Ala Gly
  10                  15                  20                  25

 ggt gaa gcc ttg ggc aga ctc ctc gtt gtt tac ccc tgg acc cag aga      387
 Gly Glu Ala Leu Gly Arg Leu Leu Val Val Tyr Pro Trp Thr Gln Arg
                  30                  35                  40

 ttt ttt gac agc ttt gga aac ctg tcg tct ccc tct gcc atc ctg ggc      435
 Phe Phe Asp Ser Phe Gly Asn Leu Ser Ser Pro Ser Ala Ile Leu Gly
              45                  50                  55

 aac ccc aag gtc aag gcc cat ggc aag aag gtg ctg act tcc ttt gga      483
 Asn Pro Lys Val Lys Ala His Gly Lys Lys Val Leu Thr Ser Phe Gly
          60                  65                  70

 gat gct att aaa aca tga cacctc agccgctttg ctagctagtc gctgcattta      537
 Asp Ala Ile Lys Thr 
      75

 caagctcatt gatccgaact tagctccggt acg                                 570




      <210> 194
      <211> 1672
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (360)..(1415)

      <400> 194
 cgcagtcccc gagcgagacc aaacaggtgg aatccgggct ggagccggag ctccggcggc     60

 gcgggtggcg gcacgtccct ccagacagta ccacaggcac ctggagtacc ggcatcggtc    120

 gctgtggccc ccgagtgtcc gtcagagcct aggggagcct gccctcccgc gcctcgtcgg    180

 ggcccggcca ggcaccttgg ccgccggcgc acggacgcgg gcacgagcac tagatcacgg    240

 ctgctggacc tcggcacgtt gacaagattt ctctggggta ccgcggagga ttactttgaa    300

 tttcggtggt cgcctgtggt ctggcatatt tagaacttaa gtctattatt tcgggcacc     359                                                                 
 atg act ttg agg ctt tta gaa gac tgg tgc agg ggg atg gac atg aac      407
 Met Thr Leu Arg Leu Leu Glu Asp Trp Cys Arg Gly Met Asp Met Asn
   1               5                  10                  15

 cct cgg aaa gcg cta ttg att gcc ggc atc tcc cag agc tgc agt gtg      455
 Pro Arg Lys Ala Leu Leu Ile Ala Gly Ile Ser Gln Ser Cys Ser Val
              20                  25                  30

 gca gaa atc gag gag gct ctg cag gct ggt tta gct ccc ttg ggg gag      503
 Ala Glu Ile Glu Glu Ala Leu Gln Ala Gly Leu Ala Pro Leu Gly Glu
          35                  40                  45

 tac aga ctg ctt gga agg atg ttc agg agg gat gag aac agg aaa gta      551
 Tyr Arg Leu Leu Gly Arg Met Phe Arg Arg Asp Glu Asn Arg Lys Val
      50                  55                  60

 gcc tta gta ggg ctt act gcg gag act agt cac gcc ctg gtc cct aag      599
 Ala Leu Val Gly Leu Thr Ala Glu Thr Ser His Ala Leu Val Pro Lys
  65                  70                  75                  80

 gag ata ccg gga aaa ggg ggt atc tgg aga gtg atc ttt aag ccc cct      647
 Glu Ile Pro Gly Lys Gly Gly Ile Trp Arg Val Ile Phe Lys Pro Pro
                  85                  90                  95

 gac cca gat aat aca ttt tta agc aga tta aat gaa ttt tta gcg gga      695
 Asp Pro Asp Asn Thr Phe Leu Ser Arg Leu Asn Glu Phe Leu Ala Gly
             100                 105                 110

 gag ggc atg aca gtg ggt gag ttg agc aga gct ctt gga cat gaa aat      743
 Glu Gly Met Thr Val Gly Glu Leu Ser Arg Ala Leu Gly His Glu Asn
         115                 120                 125

 ggc tcc tta gac cca gag cag ggc atg atc ccg gaa atg tgg gcc cct      791
 Gly Ser Leu Asp Pro Glu Gln Gly Met Ile Pro Glu Met Trp Ala Pro
     130                 135                 140

 atg ttg gca cag gca tta gag gct ctt cag cct gcc ctg caa tgc ttg      839
 Met Leu Ala Gln Ala Leu Glu Ala Leu Gln Pro Ala Leu Gln Cys Leu
 145                 150                 155                 160

 aag tat aaa aag ctg aga gtg ttc tcg ggc agg gag tct cca gaa cca      887
 Lys Tyr Lys Lys Leu Arg Val Phe Ser Gly Arg Glu Ser Pro Glu Pro
                 165                 170                 175

 gga gaa gaa gaa ttt gga cgc tgg atg ttt cat act act cag atg ata      935
 Gly Glu Glu Glu Phe Gly Arg Trp Met Phe His Thr Thr Gln Met Ile
             180                 185                 190

 aag gcg tgg cag gtg cca gat gta gag aag aga agg cga ttg cta gag      983
 Lys Ala Trp Gln Val Pro Asp Val Glu Lys Arg Arg Arg Leu Leu Glu
         195                 200                 205

 agc ctt cga ggc cca gca ctt gat gtt att cgt gtc ctc aag ata aac     1031
 Ser Leu Arg Gly Pro Ala Leu Asp Val Ile Arg Val Leu Lys Ile Asn
     210                 215                 220

 aat cct tta att act gtc gat gaa tgt ctg cag gct ctt gag gag gta     1079
 Asn Pro Leu Ile Thr Val Asp Glu Cys Leu Gln Ala Leu Glu Glu Val
 225                 230                 235                 240

 ttt ggg gtt aca gat aat cct agg gag ttg cag gtc aaa tat cta acc     1127
 Phe Gly Val Thr Asp Asn Pro Arg Glu Leu Gln Val Lys Tyr Leu Thr
                 245                 250                 255

 act tac cag aag gat gag gaa aag ttg tcg gct tat gta cta agg ctg     1175
 Thr Tyr Gln Lys Asp Glu Glu Lys Leu Ser Ala Tyr Val Leu Arg Leu
             260                 265                 270

 gag cct ttg tta cag aag ctg gta cag aga gga gca att gag aga gat     1223
 Glu Pro Leu Leu Gln Lys Leu Val Gln Arg Gly Ala Ile Glu Arg Asp
         275                 280                 285

 gct gtg aat cag gcc cgc cta gac caa gtc att gct ggg gca gtc cac     1271
 Ala Val Asn Gln Ala Arg Leu Asp Gln Val Ile Ala Gly Ala Val His
     290                 295                 300

 aaa aca att cgc aga gag ctt aat ctg cca gag gat ggc cca gcc cct     1319
 Lys Thr Ile Arg Arg Glu Leu Asn Leu Pro Glu Asp Gly Pro Ala Pro
 305                 310                 315                 320

 ggt ttc ttg cag tta ttg gta cta ata aag gat tat gag gca gct gag     1367
 Gly Phe Leu Gln Leu Leu Val Leu Ile Lys Asp Tyr Glu Ala Ala Glu
                 325                 330                 335

 gag gag gag gcc ctt ctc cag gca ata ttg gaa ggt aat ttc acc tga     1415
 Glu Glu Glu Ala Leu Leu Gln Ala Ile Leu Glu Gly Asn Phe Thr 
             340                 345                 350

 gtctcaggga accacgaagg gatatggcaa cgagtagagc atgaaggtag aacagtctat   1475

 atactcttgt gacacataca atccctacct tgtgctgcca agtaactcat ttttgtgcaa   1535

 ttctcagtat aagccctttg tcgtttctat gcctatttaa agtctcctaa aggtgtaatt   1595

 gactaggaag gatgtagttc tacactgcca tttacctatt taaattcatc cttgtgaata   1655

 tctttgttgt tgttgtt                                                  1672




      <210> 195
      <211> 1131
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(1077)

      <400> 195
 cctgcctctg gtcggttcct ggcgctctgc gtttcgtgac cttgtccagt agaaggctat     60

 ttaattttca caactgcttg aattttgaca tacaag  atg aag caa gat gcc tca     114
                                          Met Lys Gln Asp Ala Ser
                                            1               5

 aga aat gct gcc tac act gtg gat tgt gaa gat tat gtg cat gtg gta      162
 Arg Asn Ala Ala Tyr Thr Val Asp Cys Glu Asp Tyr Val His Val Val
              10                  15                  20

 gaa ttt aat ccc ttt gag aat ggg gat tca gga aac cta att gca tat      210
 Glu Phe Asn Pro Phe Glu Asn Gly Asp Ser Gly Asn Leu Ile Ala Tyr
          25                  30                  35

 ggt ggc aat aat tat gtg gtc att ggc acg tgt acg ttt cag gaa gaa      258
 Gly Gly Asn Asn Tyr Val Val Ile Gly Thr Cys Thr Phe Gln Glu Glu
      40                  45                  50

 gaa gca gac gtt gaa ggc att cag tat aaa aca ctt cga aca ttt cac      306
 Glu Ala Asp Val Glu Gly Ile Gln Tyr Lys Thr Leu Arg Thr Phe His
  55                  60                  65                  70

 cat gga gtc agg gtt gat ggc ata gct tgg agc cca gag act aga ctt      354
 His Gly Val Arg Val Asp Gly Ile Ala Trp Ser Pro Glu Thr Arg Leu
                  75                  80                  85

 gat tca ttg cct cca gta atc aaa ttt tgt act tca gct gct gat atg      402
 Asp Ser Leu Pro Pro Val Ile Lys Phe Cys Thr Ser Ala Ala Asp Met
              90                  95                 100

 aaa att aga tta ttt act tca gat ctt cag gat aaa aat gaa tat aag      450
 Lys Ile Arg Leu Phe Thr Ser Asp Leu Gln Asp Lys Asn Glu Tyr Lys
         105                 110                 115

 gtt tta gag ggc cat acc gat ttc att aat ggt ttg gtg ttt gat ccc      498
 Val Leu Glu Gly His Thr Asp Phe Ile Asn Gly Leu Val Phe Asp Pro
     120                 125                 130

 aaa gaa ggc caa gaa att gca agt gtg agt gac gat cac acc tgc agg      546
 Lys Glu Gly Gln Glu Ile Ala Ser Val Ser Asp Asp His Thr Cys Arg
 135                 140                 145                 150

 att tgg aac ttg gaa gga gtg caa aca gct cat ttt gtt ctt cat tct      594
 Ile Trp Asn Leu Glu Gly Val Gln Thr Ala His Phe Val Leu His Ser
                 155                 160                 165

 cct ggc atg agt gtg tgc tgg cat cct gag gag act ttt aag cta atg      642
 Pro Gly Met Ser Val Cys Trp His Pro Glu Glu Thr Phe Lys Leu Met
             170                 175                 180

 gtt gca gag aag aat gga aca atc cgg ttt tat gat ctt ttg gcc caa      690
 Val Ala Glu Lys Asn Gly Thr Ile Arg Phe Tyr Asp Leu Leu Ala Gln
         185                 190                 195

 cag gct att tta tct ctt gaa tca gaa caa gtg cca tta atg tca gca      738
 Gln Ala Ile Leu Ser Leu Glu Ser Glu Gln Val Pro Leu Met Ser Ala
     200                 205                 210

 cac tgg tgc tta aaa aac acc ttc aaa gtt gga gcc gtt gca gga aat      786
 His Trp Cys Leu Lys Asn Thr Phe Lys Val Gly Ala Val Ala Gly Asn
 215                 220                 225                 230

 gat tgg tta att tgg gat att act cgg tcc agt tat cct caa aat aag      834
 Asp Trp Leu Ile Trp Asp Ile Thr Arg Ser Ser Tyr Pro Gln Asn Lys
                 235                 240                 245

 aga cct gtt cac atg gat cga gcc tgc tta ttc agg tgg tcc aca att      882
 Arg Pro Val His Met Asp Arg Ala Cys Leu Phe Arg Trp Ser Thr Ile
             250                 255                 260

 agt gaa aat ctg ttt gca acc act ggt tat cct ggc aaa atg gca agc      930
 Ser Glu Asn Leu Phe Ala Thr Thr Gly Tyr Pro Gly Lys Met Ala Ser
         265                 270                 275

 cag ttt caa att cat cat tta gga cac cct cag ccc atc ctc atg ggt      978
 Gln Phe Gln Ile His His Leu Gly His Pro Gln Pro Ile Leu Met Gly
     280                 285                 290

 tct gta gcc gtt gga tct gga ctg tcc tgg cat cga act ctc cct ctg     1026
 Ser Val Ala Val Gly Ser Gly Leu Ser Trp His Arg Thr Leu Pro Leu
 295                 300                 305                 310

 tgt gta att gga gga gac cac aag ctg ttg ttt tgg gtg act gaa gta     1074
 Cys Val Ile Gly Gly Asp His Lys Leu Leu Phe Trp Val Thr Glu Val
                 315                 320                 325

 taa agtg ttttctgtac cttagattca caaactttgt atttttagta catattttga     1131
 






      <210> 196
      <211> 2875
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(2123)

      <400> 196
 tttcgtccgg gcggcgtgcc tgtggagcgc tggtggcggc ctggggctga gcatggagca     60

 acgcggcgga ggttgcctgc gaggccgctg gccaggcctg agcctctgcc acc   atg     116
                                                              Met
                                                                1

 gcc att gtg cag act ctg cca gtg cca ctg gag cct gct cct gaa gct      164
 Ala Ile Val Gln Thr Leu Pro Val Pro Leu Glu Pro Ala Pro Glu Ala
               5                  10                  15

 gcc act gcc cca caa gct cca gtc atg ggt agt gtg agc agc ctt atc      212
 Ala Thr Ala Pro Gln Ala Pro Val Met Gly Ser Val Ser Ser Leu Ile
          20                  25                  30

 tca ggc cgg ccc tgt ccc ggg ggg cca gct cct ccc cgc cac cac ggc      260
 Ser Gly Arg Pro Cys Pro Gly Gly Pro Ala Pro Pro Arg His His Gly
      35                  40                  45

 cct cct ggg ccc acc ttc ttc cgc cag cag gat ggc ctg cta cgg ggt      308
 Pro Pro Gly Pro Thr Phe Phe Arg Gln Gln Asp Gly Leu Leu Arg Gly
  50                  55                  60                  65

 ggc tat gag gca cag gag ccg ctg tgc cca gct gtg ccc cct agg aag      356
 Gly Tyr Glu Ala Gln Glu Pro Leu Cys Pro Ala Val Pro Pro Arg Lys
                  70                  75                  80

 gct gtc cct gtc acc agc ttc acc tac atc aat gag gac ttc cgg aca      404
 Ala Val Pro Val Thr Ser Phe Thr Tyr Ile Asn Glu Asp Phe Arg Thr
              85                  90                  95

 gag tca ccc ccc agc cca agc agt gat gtt gag gat gcc cga gag cag      452
 Glu Ser Pro Pro Ser Pro Ser Ser Asp Val Glu Asp Ala Arg Glu Gln
         100                 105                 110

 cgg gca cac aat gcc cac ctc cgc ggc cca cca cca aag ctc atc cct      500
 Arg Ala His Asn Ala His Leu Arg Gly Pro Pro Pro Lys Leu Ile Pro
     115                 120                 125

 gtc tct gga aag ctg gag aag aac atg gag aag atc ctg atc cgc cca      548
 Val Ser Gly Lys Leu Glu Lys Asn Met Glu Lys Ile Leu Ile Arg Pro
 130                 135                 140                 145

 aca gcc ttc aag cca gtg ctg ccc aaa cct cga ggg gct ccg tcc ctg      596
 Thr Ala Phe Lys Pro Val Leu Pro Lys Pro Arg Gly Ala Pro Ser Leu
                 150                 155                 160

 cct agc ttc atg ggt cct cgg gcc acc ggg ctg tct ggg agc cag ggc      644
 Pro Ser Phe Met Gly Pro Arg Ala Thr Gly Leu Ser Gly Ser Gln Gly
             165                 170                 175

 agc ctg acg cag ctg ttt ggg ggc cct gcc tcc tcc tcc tcc tct tcc      692
 Ser Leu Thr Gln Leu Phe Gly Gly Pro Ala Ser Ser Ser Ser Ser Ser
         180                 185                 190

 tcc tcc tct tca gct gct gac aaa ccc ctg gca ttt agt ggc tgg gcc      740
 Ser Ser Ser Ser Ala Ala Asp Lys Pro Leu Ala Phe Ser Gly Trp Ala
     195                 200                 205

 agt ggc tgc cca tca ggg acg cta tcc gac tct ggc cga aac tca ctg      788
 Ser Gly Cys Pro Ser Gly Thr Leu Ser Asp Ser Gly Arg Asn Ser Leu
 210                 215                 220                 225

 tcc agc ctg ccc acc tac agc acc gga ggt gcc gag cca acc acc agc      836
 Ser Ser Leu Pro Thr Tyr Ser Thr Gly Gly Ala Glu Pro Thr Thr Ser
                 230                 235                 240

 tcc cca ggc ggg cac ctg cct tcc cat ggc tct ggg cga ggg gca ctg      884
 Ser Pro Gly Gly His Leu Pro Ser His Gly Ser Gly Arg Gly Ala Leu
             245                 250                 255

 cct ggg cca gcc cga ggg gtc cct act ggg ccc tcc cac tca gac agt      932
 Pro Gly Pro Ala Arg Gly Val Pro Thr Gly Pro Ser His Ser Asp Ser
         260                 265                 270

 ggc cgg tcc tcc tcc agc aag agc aca ggc tcc cta ggg ggc cgt gtg      980
 Gly Arg Ser Ser Ser Ser Lys Ser Thr Gly Ser Leu Gly Gly Arg Val
     275                 280                 285

 gct ggg ggg ctt ttg ggc agt ggt act cgg gcc tcc cct gac agc agc     1028
 Ala Gly Gly Leu Leu Gly Ser Gly Thr Arg Ala Ser Pro Asp Ser Ser
 290                 295                 300                 305

 tcc tgt ggg gag cgc tca cca cca ccc ccg cct cca cct cct tcg gat     1076
 Ser Cys Gly Glu Arg Ser Pro Pro Pro Pro Pro Pro Pro Pro Ser Asp
                 310                 315                 320

 gag gcc ctg ctg cac tgt gtc ctg gaa gga aag ctc cga gac cgg gag     1124
 Glu Ala Leu Leu His Cys Val Leu Glu Gly Lys Leu Arg Asp Arg Glu
             325                 330                 335

 gca gag ctt cag cag ctg cgg gac agt ctg gac gag aat gag gct acc     1172
 Ala Glu Leu Gln Gln Leu Arg Asp Ser Leu Asp Glu Asn Glu Ala Thr
         340                 345                 350

 atg tgc cag gca tac gag gag cgg cag cgg cac tgg cag cga gag cgt     1220
 Met Cys Gln Ala Tyr Glu Glu Arg Gln Arg His Trp Gln Arg Glu Arg
     355                 360                 365

 gag gcc ctg cga gag gac tgt gcg gcc cag gca cag cgg gca cag cgg     1268
 Glu Ala Leu Arg Glu Asp Cys Ala Ala Gln Ala Gln Arg Ala Gln Arg
 370                 375                 380                 385

 gcc caa cag ctg ctg cag ctg cag gtg ttc cag ctg cag cag gag aag     1316
 Ala Gln Gln Leu Leu Gln Leu Gln Val Phe Gln Leu Gln Gln Glu Lys
                 390                 395                 400

 cgg caa ttg cag gac gac ttc gca cag ctg ctg cag gag cgc gaa cag     1364
 Arg Gln Leu Gln Asp Asp Phe Ala Gln Leu Leu Gln Glu Arg Glu Gln
             405                 410                 415

 ctg gag cgg cgc tgc gcc acc ttg gag cgg gag cag cgg gag ctc ggg     1412
 Leu Glu Arg Arg Cys Ala Thr Leu Glu Arg Glu Gln Arg Glu Leu Gly
         420                 425                 430

 ccg agg ctt gag gag acc aag tgg gag gtg tgc cag aaa tca ggc gag     1460
 Pro Arg Leu Glu Glu Thr Lys Trp Glu Val Cys Gln Lys Ser Gly Glu
     435                 440                 445

 atc tcc ctg ctg aag cag cag ctg aaa gag tct cag gca gag ctg gtg     1508
 Ile Ser Leu Leu Lys Gln Gln Leu Lys Glu Ser Gln Ala Glu Leu Val
 450                 455                 460                 465

 cag aag ggc agc gag ctg gtg gct ctg cgg gtg gcg ctg cgg gag gcc     1556
 Gln Lys Gly Ser Glu Leu Val Ala Leu Arg Val Ala Leu Arg Glu Ala
                 470                 475                 480

 cgt gct acg ctg cgg gtc agt gag ggc cgt gcg cgg ggt cta cag gag     1604
 Arg Ala Thr Leu Arg Val Ser Glu Gly Arg Ala Arg Gly Leu Gln Glu
             485                 490                 495

 gcc gcc cga gct cgg gag ctg gag ctg gaa gcc tgt tcc cag gag ctg     1652
 Ala Ala Arg Ala Arg Glu Leu Glu Leu Glu Ala Cys Ser Gln Glu Leu
         500                 505                 510

 cag cga cac cgc cag gaa gct gag cag ctg cgg gag aaa gct ggg cag     1700
 Gln Arg His Arg Gln Glu Ala Glu Gln Leu Arg Glu Lys Ala Gly Gln
     515                 520                 525

 ttg gat gct gag gcg gcc gga ctc cgg gag ccc cct gtg cca cct gcc     1748
 Leu Asp Ala Glu Ala Ala Gly Leu Arg Glu Pro Pro Val Pro Pro Ala
 530                 535                 540                 545

 acc gct gac cca ttc ctc ctg gca gag agt gat gag gcc aaa gtg cag     1796
 Thr Ala Asp Pro Phe Leu Leu Ala Glu Ser Asp Glu Ala Lys Val Gln
                 550                 555                 560

 cgg gca gca gcc ggg gtt ggg ggc agc ttg cgg gcc cag gtg gag cga     1844
 Arg Ala Ala Ala Gly Val Gly Gly Ser Leu Arg Ala Gln Val Glu Arg
             565                 570                 575

 ttg cgg gtg gag ctg cag cgg gag cgg cgg cgg ggt gag gag cag cgg     1892
 Leu Arg Val Glu Leu Gln Arg Glu Arg Arg Arg Gly Glu Glu Gln Arg
         580                 585                 590

 gac agc ttt gag ggg gag cgg ctg gcc tgg cag gca gag aag gag cag     1940
 Asp Ser Phe Glu Gly Glu Arg Leu Ala Trp Gln Ala Glu Lys Glu Gln
     595                 600                 605

 gtg atc cgc tac cag aag cag ctg cag cac aac tac atc cag atg tac     1988
 Val Ile Arg Tyr Gln Lys Gln Leu Gln His Asn Tyr Ile Gln Met Tyr
 610                 615                 620                 625

 cgg cgc aac cgg cag cta gag cag gag ctg cag cag ctc agc ctg gag     2036
 Arg Arg Asn Arg Gln Leu Glu Gln Glu Leu Gln Gln Leu Ser Leu Glu
                 630                 635                 640

 ctg gag gcc cgg gag ctc gct gac ctg ggc ctg gcc gag cag gcc ccc     2084
 Leu Glu Ala Arg Glu Leu Ala Asp Leu Gly Leu Ala Glu Gln Ala Pro
             645                 650                 655

 tgc atc tgc ctg gag gag atc act gct act gag atc tag ggccctcagc      2133
 Cys Ile Cys Leu Glu Glu Ile Thr Ala Thr Glu Ile 
         660                 665

 aaccagctct gtagggagct ctgccagagg ggcagcagct gcagatccac ttaggcccca   2193

 gggtccacgg atggccccaa aggctgaggg ccccaaagcc acttgtctcc taggatccag   2253

 gcctctgggc ttctgccaag aactcagggt ggccctatga cttggaggag caagatcaga   2313

 ccgctcaaag gtccccgtgt tcactgttac ccagaggctc ttgttactac ccacttcatt   2373

 ccccaccgct gccagtgcca ctgccaaccc tgttcacagg cgcttccagc ccactccagc   2433

 caggggagca gggaagaaga aggggctccc tcctcttcac attccccccg accccaaagc   2493

 cagagaaagc cagatggcac cagctgctcc ggatgtgcct gcccacattg ggggacaggg   2553

 ccgggcctgg gcagctggtg ccatctggag cagctggtgc cagctgctcc ggatgtgcct   2613

 gcccacattg ggggacaggg ccgggcctgg gctcggttcc caggtttgag ctctgcagcc   2673

 tctctcctgg agtgaggggg ctgaagtcag accaaaggaa gaactcagaa atgtcttgtt   2733

 tatttgtgtt tgtgaccaag cagcctctcc cttcacccag gtttatggcc tcgttttcac   2793

 ttgtatattt ttcacactgt aaatttcttg tacaaaccca aagaaaaaat taaaaaaaat   2853

 ttttttgttt aaaaaaaaaa aa                                            2875




      <210> 197
      <211> 1452
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (35)..(1270)

      <400> 197
 ctcgggggcg gcgctcagaa aacatctgga gaaa    atg acc cat tgg ttt cat      52
                                          Met Thr His Trp Phe His
                                            1               5

 agg aac cca tta aaa gcc aca gct cct gtg tct ttt aat tac tat ggt      100
 Arg Asn Pro Leu Lys Ala Thr Ala Pro Val Ser Phe Asn Tyr Tyr Gly
              10                  15                  20

 gta gtc act ggc cct tct gct tca aaa ata tgc aat gac ttg agg tca      148
 Val Val Thr Gly Pro Ser Ala Ser Lys Ile Cys Asn Asp Leu Arg Ser
          25                  30                  35

 tcc agg gca cga ctc ctt gaa ctg ttc act gat ttg agc tgt aat cca      196
 Ser Arg Ala Arg Leu Leu Glu Leu Phe Thr Asp Leu Ser Cys Asn Pro
      40                  45                  50

 gaa atg atg aag aat gca gca gat tca tat ttc tca ctt tta caa ggt      244
 Glu Met Met Lys Asn Ala Ala Asp Ser Tyr Phe Ser Leu Leu Gln Gly
  55                  60                  65                  70

 ttc ata aat tct ttg gat gaa tct acc caa gaa agc aag tta cga tat      292
 Phe Ile Asn Ser Leu Asp Glu Ser Thr Gln Glu Ser Lys Leu Arg Tyr
                  75                  80                  85

 att caa aat ttc aag tgg act gat aca ttg caa gga cag gtt cca agt      340
 Ile Gln Asn Phe Lys Trp Thr Asp Thr Leu Gln Gly Gln Val Pro Ser
              90                  95                 100

 gcc cag cag gat gct gtt ttt gaa tta att tcc atg gga ttt aat gta      388
 Ala Gln Gln Asp Ala Val Phe Glu Leu Ile Ser Met Gly Phe Asn Val
         105                 110                 115

 gct tta tgg tat acc aaa tat gct tca aga ctg gct gga aaa gaa aat      436
 Ala Leu Trp Tyr Thr Lys Tyr Ala Ser Arg Leu Ala Gly Lys Glu Asn
     120                 125                 130

 ata aca gaa gat gaa gca aaa gaa gtt cat cga agc cta aag att gca      484
 Ile Thr Glu Asp Glu Ala Lys Glu Val His Arg Ser Leu Lys Ile Ala
 135                 140                 145                 150

 gct ggg att ttt aaa cat tta aag gaa agt cat ctc cca aaa ctc att      532
 Ala Gly Ile Phe Lys His Leu Lys Glu Ser His Leu Pro Lys Leu Ile
                 155                 160                 165

 aca cct gcg gaa aaa gga aga gat tta gag tca cga ctc ata gaa gca      580
 Thr Pro Ala Glu Lys Gly Arg Asp Leu Glu Ser Arg Leu Ile Glu Ala
             170                 175                 180

 tac gtt att caa tgt cag gct gaa gct caa gaa gta aca att gct cga      628
 Tyr Val Ile Gln Cys Gln Ala Glu Ala Gln Glu Val Thr Ile Ala Arg
         185                 190                 195

 gca att gaa cta aaa cat gct cct gga cta att gct gca ctg gcg tat      676
 Ala Ile Glu Leu Lys His Ala Pro Gly Leu Ile Ala Ala Leu Ala Tyr
     200                 205                 210

 gaa aca gcc aat ttc tat caa aaa gct gat cat act tta tcc agt ttg      724
 Glu Thr Ala Asn Phe Tyr Gln Lys Ala Asp His Thr Leu Ser Ser Leu
 215                 220                 225                 230

 gag cct gca tat tct gcc aaa tgg aga aaa tat ctt cac ttg aag atg      772
 Glu Pro Ala Tyr Ser Ala Lys Trp Arg Lys Tyr Leu His Leu Lys Met
                 235                 240                 245

 tgt ttc tac aca gct tat gct tac tgt tac cat ggt gag act tta ttg      820
 Cys Phe Tyr Thr Ala Tyr Ala Tyr Cys Tyr His Gly Glu Thr Leu Leu
             250                 255                 260

 gct agt gat aaa tgc ggt gaa gca atc agg tct ctc caa gaa gca gaa      868
 Ala Ser Asp Lys Cys Gly Glu Ala Ile Arg Ser Leu Gln Glu Ala Glu
         265                 270                 275

 aaa ttg tat gca aag gca gaa gca ctg tgt aaa gaa tat gga gaa acc      916
 Lys Leu Tyr Ala Lys Ala Glu Ala Leu Cys Lys Glu Tyr Gly Glu Thr
     280                 285                 290

 aaa gga cct gga cca aca gtc aaa cct tca gga cat ctg ttc ttt agg      964
 Lys Gly Pro Gly Pro Thr Val Lys Pro Ser Gly His Leu Phe Phe Arg
 295                 300                 305                 310

 aaa ctt gga aac ctt gtg aag aac acc cta gaa aaa tgt cag aga gaa     1012
 Lys Leu Gly Asn Leu Val Lys Asn Thr Leu Glu Lys Cys Gln Arg Glu
                 315                 320                 325

 aat gga ttt att tac ttt caa aaa att cca aca gaa gcc cca cag ctg     1060
 Asn Gly Phe Ile Tyr Phe Gln Lys Ile Pro Thr Glu Ala Pro Gln Leu
             330                 335                 340

 gaa ctc aaa gca aat tat ggt ctc gta gag cct ata cct ttc gaa ttt     1108
 Glu Leu Lys Ala Asn Tyr Gly Leu Val Glu Pro Ile Pro Phe Glu Phe
         345                 350                 355

 cct cct aca agt gtt cag tgg aca cca gaa aca ttg gct gca ttt gat     1156
 Pro Pro Thr Ser Val Gln Trp Thr Pro Glu Thr Leu Ala Ala Phe Asp
     360                 365                 370

 ctc acc aaa aga ccc aag gat gac agt act aaa ccc aaa cca gaa gaa     1204
 Leu Thr Lys Arg Pro Lys Asp Asp Ser Thr Lys Pro Lys Pro Glu Glu
 375                 380                 385                 390

 gaa gtg aaa cct gtg aaa gaa cca gac atc aaa cct caa aag gac act     1252
 Glu Val Lys Pro Val Lys Glu Pro Asp Ile Lys Pro Gln Lys Asp Thr
                 395                 400                 405

 ggg tgc tac atc tcc taa aataca acttgcactt agaatttctc tagcagtaaa     1306
 Gly Cys Tyr Ile Ser 
             410

 taagataaac cacagaattt cagttcttat ttctcaaaat gatttctctg aagcttgtag   1366

 aataactatt attcagaggg ttatctgcct tcagcttact tgttcttaat ttttaataca   1426

 gcggagatgt ttcttgaaaa aaaaaa                                        1452




      <210> 198
      <211> 1250
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (84)..(917)

      <400> 198
 atggggaagt ggaagcgccg ggccctgctg cgggggggag agccactgac gccgggaccg     60

 ggaccgccgc cgccgccgcc acc    atg agt gat cag cag ctg gac tgt gcc     110
                              Met Ser Asp Gln Gln Leu Asp Cys Ala
                                1               5

 ttg gac cta atg agg cgc ctg cct ccc cag caa atc gag aaa aac ctc      158
 Leu Asp Leu Met Arg Arg Leu Pro Pro Gln Gln Ile Glu Lys Asn Leu
  10                  15                  20                  25

 agc gac ctg atc gac ctg gtc ccc agt cta tgt gag gat ctc ctg tct      206
 Ser Asp Leu Ile Asp Leu Val Pro Ser Leu Cys Glu Asp Leu Leu Ser
                  30                  35                  40

 tct gtt gac cag cca ctg aaa att gcc aga gac aag gtg gtg gga aag      254
 Ser Val Asp Gln Pro Leu Lys Ile Ala Arg Asp Lys Val Val Gly Lys
              45                  50                  55

 gat tac ctt ttg tgt gac tac aac aga gat ggg gac tcc tat agg tca      302
 Asp Tyr Leu Leu Cys Asp Tyr Asn Arg Asp Gly Asp Ser Tyr Arg Ser
          60                  65                  70

 cca tgg agt aac aag tat gac cct ccc ttg gag gat ggg gcc atg ccg      350
 Pro Trp Ser Asn Lys Tyr Asp Pro Pro Leu Glu Asp Gly Ala Met Pro
      75                  80                  85

 tca gct cgg ctg aga aag ctg gag gtg gaa gcc aac aat gcc ttt gac      398
 Ser Ala Arg Leu Arg Lys Leu Glu Val Glu Ala Asn Asn Ala Phe Asp
  90                  95                 100                 105

 cag tat cga gac ctg tat ttt gaa ggt ggc gtc tca tct gtc tac ctc      446
 Gln Tyr Arg Asp Leu Tyr Phe Glu Gly Gly Val Ser Ser Val Tyr Leu
                 110                 115                 120

 tgg gat ctg gat cat ggc ttt gct gga gtg atc ctc ata aag aag gct      494
 Trp Asp Leu Asp His Gly Phe Ala Gly Val Ile Leu Ile Lys Lys Ala
             125                 130                 135

 gga gat gga tca aag aag atc aaa ggc tgc tgg gat tcc atc cac gtg      542
 Gly Asp Gly Ser Lys Lys Ile Lys Gly Cys Trp Asp Ser Ile His Val
         140                 145                 150

 gta gaa gtg cag gag aaa tcc agc ggt cgc acc gcc cat tac aag ttg      590
 Val Glu Val Gln Glu Lys Ser Ser Gly Arg Thr Ala His Tyr Lys Leu
     155                 160                 165

 acc tcc acg gtg atg ctg tgg ctg cag acc aac aaa tct ggc tct ggc      638
 Thr Ser Thr Val Met Leu Trp Leu Gln Thr Asn Lys Ser Gly Ser Gly
 170                 175                 180                 185

 acc atg aac ctc gga ggc agc ctt acc aga cag atg gag aag gat gaa      686
 Thr Met Asn Leu Gly Gly Ser Leu Thr Arg Gln Met Glu Lys Asp Glu
                 190                 195                 200

 act gtg agt gac tgc tcc cca cac ata gcc aac atc ggg cgc ctg gta      734
 Thr Val Ser Asp Cys Ser Pro His Ile Ala Asn Ile Gly Arg Leu Val
             205                 210                 215

 gag gac atg gaa aat aaa atc aga agt acg ctg aac gag atc tac ttt      782
 Glu Asp Met Glu Asn Lys Ile Arg Ser Thr Leu Asn Glu Ile Tyr Phe
         220                 225                 230

 gga aaa aca aag gat atc gtc aat ggg ctg aga tct att gat gct atc      830
 Gly Lys Thr Lys Asp Ile Val Asn Gly Leu Arg Ser Ile Asp Ala Ile
     235                 240                 245

 cct gac aac caa aag ttt aag cag ttg cag agg gag ctc tct caa gtg      878
 Pro Asp Asn Gln Lys Phe Lys Gln Leu Gln Arg Glu Leu Ser Gln Val
 250                 255                 260                 265

 ctg acc cag cgc cag atc tac atc cag cct gat aat taa gccgatccag       927
 Leu Thr Gln Arg Gln Ile Tyr Ile Gln Pro Asp Asn 
                 270                 275

 gtaccctgcc tgagagccgc gagaccctcc ccactaaaac aggactcacc aacccgccga    987

 gaccctgccg gtccggctgc tgctccgcgg ccatttaaac caccactaac ccccacgtgt   1047

 gctcccggtc ggtgcacagc cacattcccg tgtagcctcg gccccatgta acacggcacc   1107

 tatcacgtgt gtgtgctttc cactctgggt ggaggctggg tgtggggaag acggctgatt   1167

 ttttggcttt tgcttctgaa gaagcccagg ccaagggacg gatgctgcct ctccagcagc   1227

 agccacttgt gtgcaccggc ctg                                           1250




      <210> 199
      <211> 4015
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (314)..(2167)

      <400> 199
 aagcttgcgg ccgcaggcgg agcagggcgg cccgggcggc ggtggggaca acggtttccc     60

 tttgaagggg acggacaaag cccgagtgac cagcggcggc ggggaggact agtccccggg    120

 cagtttggtg ccctggttgt cagatgttgg aaagcagtag gacggaacat actcttcgtg    180

 gttgtgtatc cgttctgggg tgcagcaatt aacattggac tttggttcct gtgactcttg    240

 cctgtgtcga tagagttaaa ctggagctct gctttgaaag ataaataaag cacagcctct    300

 caactggaca taa   atg gat cta aag aca gca gta ttt aac gca gct cgg     349
                  Met Asp Leu Lys Thr Ala Val Phe Asn Ala Ala Arg
                    1               5                  10

 gat ggc aaa ctc cgg ctt ctc acc aaa ttg ttg gca agc aaa tcc aaa      397
 Asp Gly Lys Leu Arg Leu Leu Thr Lys Leu Leu Ala Ser Lys Ser Lys
          15                  20                  25

 gag gag gtt tcc tcc ttg atc tct gaa aaa aca aat ggg gcc acg cca      445
 Glu Glu Val Ser Ser Leu Ile Ser Glu Lys Thr Asn Gly Ala Thr Pro
      30                  35                  40

 ctc ttg atg gcc gcc agg tat ggg cac ctt gac atg gtg gaa ttc ctc      493
 Leu Leu Met Ala Ala Arg Tyr Gly His Leu Asp Met Val Glu Phe Leu
  45                  50                  55                  60

 cta gag caa tgc agt gcc tcc ata gaa gtt ggg ggc tcc gtc aat ttt      541
 Leu Glu Gln Cys Ser Ala Ser Ile Glu Val Gly Gly Ser Val Asn Phe
                  65                  70                  75

 gat ggc gaa acc att gag ggg gct ccc cct tta tgg gcc gct tct gca      589
 Asp Gly Glu Thr Ile Glu Gly Ala Pro Pro Leu Trp Ala Ala Ser Ala
              80                  85                  90

 gca gga cat ctg aag gtg gtc cag tcc ttg tta aat cat gga gca tct      637
 Ala Gly His Leu Lys Val Val Gln Ser Leu Leu Asn His Gly Ala Ser
          95                 100                 105

 gtc aac aac acg act tta acc aat tca act cct ctt cga gct gcg tgt      685
 Val Asn Asn Thr Thr Leu Thr Asn Ser Thr Pro Leu Arg Ala Ala Cys
     110                 115                 120

 ttc gat ggc cat ttg gaa ata gtg aag tac ctt gta gaa cac aaa gct      733
 Phe Asp Gly His Leu Glu Ile Val Lys Tyr Leu Val Glu His Lys Ala
 125                 130                 135                 140

 gat ttg gaa gtg tca aac cga cat ggg cat acg tgc ttg atg att tca      781
 Asp Leu Glu Val Ser Asn Arg His Gly His Thr Cys Leu Met Ile Ser
                 145                 150                 155

 tgt tac aaa gga cat aaa gag att gct cag tat tta ctt gaa aag ggg      829
 Cys Tyr Lys Gly His Lys Glu Ile Ala Gln Tyr Leu Leu Glu Lys Gly
             160                 165                 170

 gca gat gtt aat aga aaa agt gtc aaa ggt aat act gca ttg cat gat      877
 Ala Asp Val Asn Arg Lys Ser Val Lys Gly Asn Thr Ala Leu His Asp
         175                 180                 185

 tgt gca gaa tct gga agt ttg gac atc atg aag atg ctt ctt atg tat      925
 Cys Ala Glu Ser Gly Ser Leu Asp Ile Met Lys Met Leu Leu Met Tyr
     190                 195                 200

 tgt gcc aag atg gaa aag gat ggt tat gga atg act ccc ctt ctc tca      973
 Cys Ala Lys Met Glu Lys Asp Gly Tyr Gly Met Thr Pro Leu Leu Ser
 205                 210                 215                 220

 gca agt gtg act ggt cac aca aat att gtg gat ttt ctg aca cac cat     1021
 Ala Ser Val Thr Gly His Thr Asn Ile Val Asp Phe Leu Thr His His
                 225                 230                 235

 gca cag acc agc aag aca gaa cgt att aat gct cta gag ctt ctg gga     1069
 Ala Gln Thr Ser Lys Thr Glu Arg Ile Asn Ala Leu Glu Leu Leu Gly
             240                 245                 250

 gct aca ttt gta gac aaa aaa aga gat ctg ctt ggg gct ttg aaa tac     1117
 Ala Thr Phe Val Asp Lys Lys Arg Asp Leu Leu Gly Ala Leu Lys Tyr
         255                 260                 265

 tgg aaa aag gca atg aac atg agg tac agt gat agg act aat att att     1165
 Trp Lys Lys Ala Met Asn Met Arg Tyr Ser Asp Arg Thr Asn Ile Ile
     270                 275                 280

 agt aaa cca gtg cca cag aca cta ata atg gct tat gat tat gcc aag     1213
 Ser Lys Pro Val Pro Gln Thr Leu Ile Met Ala Tyr Asp Tyr Ala Lys
 285                 290                 295                 300

 gaa gtg aac agt gca gaa gag cta gaa ggt ctt att gct gat cct gat     1261
 Glu Val Asn Ser Ala Glu Glu Leu Glu Gly Leu Ile Ala Asp Pro Asp
                 305                 310                 315

 gag atg aga atg cag gca cta tta atc aga gaa cgt att ctt ggt cct     1309
 Glu Met Arg Met Gln Ala Leu Leu Ile Arg Glu Arg Ile Leu Gly Pro
             320                 325                 330

 tct cat cct gat acc tct tac tat att aga tat aga ggc gct gtc tat     1357
 Ser His Pro Asp Thr Ser Tyr Tyr Ile Arg Tyr Arg Gly Ala Val Tyr
         335                 340                 345

 gca gac tct gga aat ttc aaa cga tgc atc aac cta tgg aag tat gct     1405
 Ala Asp Ser Gly Asn Phe Lys Arg Cys Ile Asn Leu Trp Lys Tyr Ala
     350                 355                 360

 ttg gat atg cag cag agc aat ttg gat cct tta agc cca atg acc gcc     1453
 Leu Asp Met Gln Gln Ser Asn Leu Asp Pro Leu Ser Pro Met Thr Ala
 365                 370                 375                 380

 agc agc tta tta tct ttt gca gaa cta ttc tcc ttt atg cta cag gat     1501
 Ser Ser Leu Leu Ser Phe Ala Glu Leu Phe Ser Phe Met Leu Gln Asp
                 385                 390                 395

 agg gct aaa ggc ctg ctg ggt act act gtt aca ttt gat gat ctt atg     1549
 Arg Ala Lys Gly Leu Leu Gly Thr Thr Val Thr Phe Asp Asp Leu Met
             400                 405                 410

 ggc ata ctt tgc aaa agc gtc ctt gaa ata gag cga gct atc aaa caa     1597
 Gly Ile Leu Cys Lys Ser Val Leu Glu Ile Glu Arg Ala Ile Lys Gln
         415                 420                 425

 act cag tgt cca gct gac cca tta cag tta aat aag gcc ctt tct att     1645
 Thr Gln Cys Pro Ala Asp Pro Leu Gln Leu Asn Lys Ala Leu Ser Ile
     430                 435                 440

 att ttg cac tta att tgc ttg tta gag aaa gtt cct tgt act cta gaa     1693
 Ile Leu His Leu Ile Cys Leu Leu Glu Lys Val Pro Cys Thr Leu Glu
 445                 450                 455                 460

 caa gac cat ttc aaa aag cag act ata tac agg ttt ctt aag ctg cat     1741
 Gln Asp His Phe Lys Lys Gln Thr Ile Tyr Arg Phe Leu Lys Leu His
                 465                 470                 475

 cca agg gga aag aat aac ttc agc cct ctt cat ctg gct gtg gac aag     1789
 Pro Arg Gly Lys Asn Asn Phe Ser Pro Leu His Leu Ala Val Asp Lys
             480                 485                 490

 aat act aca tgt gta ggg cgg tac cct gtt tgt aaa ttt cca tct cta     1837
 Asn Thr Thr Cys Val Gly Arg Tyr Pro Val Cys Lys Phe Pro Ser Leu
         495                 500                 505

 caa gtt act gca ata ctg ata gaa tgt ggt gct gat gtg aac gtc aga     1885
 Gln Val Thr Ala Ile Leu Ile Glu Cys Gly Ala Asp Val Asn Val Arg
     510                 515                 520

 gac tcg gat gac aac agt ccc ctg cat atc gct gct ctt aac aac cat     1933
 Asp Ser Asp Asp Asn Ser Pro Leu His Ile Ala Ala Leu Asn Asn His
 525                 530                 535                 540

 cca gac atc atg aat ctc ctt att aaa tca ggt gca cat ttt gat gcc     1981
 Pro Asp Ile Met Asn Leu Leu Ile Lys Ser Gly Ala His Phe Asp Ala
                 545                 550                 555

 aca aac ttg cac aaa caa act gct agt gac ttg ctg gat gag aag gaa     2029
 Thr Asn Leu His Lys Gln Thr Ala Ser Asp Leu Leu Asp Glu Lys Glu
             560                 565                 570

 ata gct aaa aat tta atc cag cct ata aat cat acc aca ttg cag tgt     2077
 Ile Ala Lys Asn Leu Ile Gln Pro Ile Asn His Thr Thr Leu Gln Cys
         575                 580                 585

 ctt gct gct cgt gtc ata gtg aat cat aga ata tat tat aaa ggg cat     2125
 Leu Ala Ala Arg Val Ile Val Asn His Arg Ile Tyr Tyr Lys Gly His
     590                 595                 600

 atc cca gaa aag cta gag act ttt gtt tcc ctt cat aga tga taacttg     2174
 Ile Pro Glu Lys Leu Glu Thr Phe Val Ser Leu His Arg 
 605                 610                 615

 actgtatttt agcactgtta aagcacgaat tggtaacagt tgtttcataa atgagcactg   2234

 ttgtgataac accagcattc atttagcttg attgatatca ttgtgctctc attggctaaa   2294

 gcattataag catcaaattt acaacattgg tttcccaata tttaatataa atataccata   2354

 taatatattg tttgtgaatt attgagaaat gtaacattca aatttctaaa attgtctgcc   2414

 aaaggcttat tcattctggt tttgtttgct gttgggtgtt tggggcaaag ttaaccattt   2474

 ctccatggtg tctttatact ttactggttt gtgaatttta tacaattgaa agtctttttt   2534

 tcttgcttct ttcttctctt ctcaagtttc ccccctgttt ctactttatt gtttgtccta   2594

 accatttcta ctacagtttt ttccttatgg acccatacta ggttgtacaa accttaagga   2654

 ctcgttacca tttgcagtta ccataagtgc tttatcttct ctatgcacag gcttaaactt   2714

 gactgttgta tgttagcata ttttctatgc agcagttggt caacttcaac tcaaaacact   2774

 gttttcttat gtttgttaca aacttaattt tttgaaagta ctctgtagca tgacaatttt   2834

 tagagctgca ggttagctat tatagctcaa gcttttttgt ttgttttttt cttcactttc   2894

 ttcacatctg aggtttcttt ctctaatcca ctgaaattat tgtgtgctaa atttgggaaa   2954

 cagatctatt ctaactcatt aacccagttg aaatttaggt ctgtcatctt aatatatcat   3014

 gcagtaaaag gaagaatctt tttaaagtga cccacctttc atgctgctcc agcattgtcc   3074

 tgcttgtgct gatggtgtga ttaggtgtag agaatttgct taaatttaac ttcaaagttc   3134

 atcacacagc ttaatgagtc acattgaaat actcagtaat tgaactgcaa atcactttta   3194

 gttacaaaaa gagctaaagc atgtcagtgg catgatgctt gccaagccag atctaggcat   3254

 ctaggataat taaggtattt tagtatgcaa tttactgcca taatatcaaa ggtcagtaac   3314

 agtgttcttt ctttcttcaa gcttatgtat acctttaaag ataacttgca tgaattactt   3374

 tgattacttt ggtctcaatt atttgtcacc ccagttaaac atgaaaggtt gcagtgcttc   3434

 ctgttccctt actggaagtt agctttttct tttctctttc ttcctttctt tctctcactc   3494

 tttctttctc tttctctttc tctctctctc tctctctcac tcactcactc acagatttgc   3554

 taatgccaca gaaagggctc ttttaactta agataagtga aaagtactaa aaaagattca   3614

 ggtaattatc attcagcact ttattgtaat tcagaataaa atttatgatg gcatatttgc   3674

 cctgcaaatg tcttaatgaa gttgttctca ataaaaagct ccttattgat ttgagaaaaa   3734

 ctcagtttac ctgtgagttc aatgagctgg atcactcact tggatttttg tgttgacatt   3794

 ttattctgag ggttgatgtt acactattta aggagtcatc aatgcaaaca gtcacattag   3854

 gtatgtcatc atctttagtc agtaaaaacc ttgtaatgag gagtagtaaa taaacaagag   3914

 aacattagac tttttggtta aataattgag atttaatttt taaaagatat tcttactcat   3974

 ttgctaggtt gtaaatttga tttcaccatt aagaaaaggg t                       4015




      <210> 200
      <211> 1079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (383)..(610)

      <400> 200
 gcttacaggg tcttcacatg cttactagct acagttacgt cacttaatca tgtgtaataa     60

 atggctcgtg taattttgag tcacttaaag tgatcagatt gttttaattg tgaagcatgt    120

 gaataaataa atgagatttc caccgtctgg tactatatac gtaaaactag aggctttgca    180

 aaattaccaa gagacgatcc cgtttgatgt gtctttggtt tggcacaggt ggagcagaca    240

 tgtgagatat agaatgaatg ggaggccttc acacttactc actatgtgga aggtggtagt    300

 tgatcatgat ggtcagttcc ataggcctcc aggccactgg tgacacacta ccactgttgc    360

 cataattctt aaaagtcatt tt atg tgg ggc tcc ttc cta gca acc tcc ctc     412
                          Met Trp Gly Ser Phe Leu Ala Thr Ser Leu
                            1               5                  10

 aaa cac ata gct cca tcc ctt cca aga gct aag aaa ttt tta gca ctt      460
 Lys His Ile Ala Pro Ser Leu Pro Arg Ala Lys Lys Phe Leu Ala Leu
                  15                  20                  25

 gcc acc atc tat ttg ttc att tgt tta ctg att aca ttc ctc cca tta      508
 Ala Thr Ile Tyr Leu Phe Ile Cys Leu Leu Ile Thr Phe Leu Pro Leu
              30                  35                  40

 gta tat aag ctc cgt gat aat aga aac ttt gtc cac tat tgt ata ttt      556
 Val Tyr Lys Leu Arg Asp Asn Arg Asn Phe Val His Tyr Cys Ile Phe
          45                  50                  55

 cta act cct aag aca cta ttg gcg tat tat agt atg cag tta ata cta      604
 Leu Thr Pro Lys Thr Leu Leu Ala Tyr Tyr Ser Met Gln Leu Ile Leu
      60                  65                  70

 gaa taa atgggatttc tgtttgttct tactgaggtt tgcaaagctt catgaaagtg       660
 Glu 
  75

 gaatataaag attctcgttg ttctgtgtgc attggggaca tggaacggaa cttgtgtttt    720

 ctgagtgagg gagcctctgg cagagagtct aactgcaatc cattattccc tgtgactggg    780

 cagaatttaa aaatttttaa gagaagagat gaaaaatctt ctggattcct acttaattta    840

 gacatgggtt tggctcttaa cgaaaaactt taacctacct acagggaagg ctttttcgct    900

 gttaccctta cttctgtctc ctggatctta tgagtggaga aatgagcctt tgtttcactt    960

 acaaatccac aaatatttat gctgtcatat gaacacatgt ataaggcgct gtgtcacatt   1020

 gtggaagata caaagagaca ggattcctga gatcgtagct acgttaagca tgagtgtta    1079




      <210> 201
      <211> 2796
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (175)..(1461)

      <400> 201
 tttcgtctct ctgtcagtgg cggctgctgc ctgctctgga ggcaggctgg gcggtggcgg     60

 ccgagactgg cgggggtgga cgcccgggcc gggctgcgcc cgcttcttgc agctgtgaat    120

 tcctttggac aattgatgat atttatcatt gtgcccagtt tctacaaata aaag  atg     177
                                                              Met
                                                                1

 ggt gga tta ttt tct cga tgg agg aca aaa cct tca act gta gaa gtt      225
 Gly Gly Leu Phe Ser Arg Trp Arg Thr Lys Pro Ser Thr Val Glu Val
               5                  10                  15

 cta gaa agt ata gat aag gaa att caa gca ttg gaa gaa ttt agg gaa      273
 Leu Glu Ser Ile Asp Lys Glu Ile Gln Ala Leu Glu Glu Phe Arg Glu
          20                  25                  30

 aaa aat cag aga tta caa aaa tta tgg gtt gga aga tta att ctg tat      321
 Lys Asn Gln Arg Leu Gln Lys Leu Trp Val Gly Arg Leu Ile Leu Tyr
      35                  40                  45

 tcc tca gtt ctc tat ctg ttt aca tgc tta att gta tat ttg tgg tat      369
 Ser Ser Val Leu Tyr Leu Phe Thr Cys Leu Ile Val Tyr Leu Trp Tyr
  50                  55                  60                  65

 ctt cct gat gaa ttt aca gca aga ctt gcc atg aca ctc cca ttt ttt      417
 Leu Pro Asp Glu Phe Thr Ala Arg Leu Ala Met Thr Leu Pro Phe Phe
                  70                  75                  80

 gct ttt cca ttg atc atc tgg agc ata aga aca gta att att ttc ttc      465
 Ala Phe Pro Leu Ile Ile Trp Ser Ile Arg Thr Val Ile Ile Phe Phe
              85                  90                  95

 ttt tcc aag aga aca gaa aga aat aat gaa gca ttg gat gat tta aaa      513
 Phe Ser Lys Arg Thr Glu Arg Asn Asn Glu Ala Leu Asp Asp Leu Lys
         100                 105                 110

 tcc cag agg aaa aaa ata ctt gaa gaa gtc atg gaa aaa gaa act tac      561
 Ser Gln Arg Lys Lys Ile Leu Glu Glu Val Met Glu Lys Glu Thr Tyr
     115                 120                 125

 aag acg gct aaa tta att ctt gaa agg ttt gat ccg gac tca aag aaa      609
 Lys Thr Ala Lys Leu Ile Leu Glu Arg Phe Asp Pro Asp Ser Lys Lys
 130                 135                 140                 145

 gca aag gag tgt gag ccg cca tct gct gga gca gct gta act gca aga      657
 Ala Lys Glu Cys Glu Pro Pro Ser Ala Gly Ala Ala Val Thr Ala Arg
                 150                 155                 160

 cct gga caa gag att cgt cag cga act gca gct caa aga aac ctt tct      705
 Pro Gly Gln Glu Ile Arg Gln Arg Thr Ala Ala Gln Arg Asn Leu Ser
             165                 170                 175

 cca aca cca gca agc cct aac cag ggc cct cct cca caa gtt cca gta      753
 Pro Thr Pro Ala Ser Pro Asn Gln Gly Pro Pro Pro Gln Val Pro Val
         180                 185                 190

 tct cct gga cca cca aag gac agt tct gcc cct ggt gga ccc cca gaa      801
 Ser Pro Gly Pro Pro Lys Asp Ser Ser Ala Pro Gly Gly Pro Pro Glu
     195                 200                 205

 agg act gtt act cca gcc cta tca tca aat gtg tta cca aga cat ctt      849
 Arg Thr Val Thr Pro Ala Leu Ser Ser Asn Val Leu Pro Arg His Leu
 210                 215                 220                 225

 gga tcc cct gct act tca gtg cct gga atg ggt ctt cat cct cca ggt      897
 Gly Ser Pro Ala Thr Ser Val Pro Gly Met Gly Leu His Pro Pro Gly
                 230                 235                 240

 cca cct tta gca aga cct att ctc ccc cga gaa cga ggt gct ttg gat      945
 Pro Pro Leu Ala Arg Pro Ile Leu Pro Arg Glu Arg Gly Ala Leu Asp
             245                 250                 255

 aga att gtt gaa tat ttg gtt ggt gat ggt cca caa aac agg tat gca      993
 Arg Ile Val Glu Tyr Leu Val Gly Asp Gly Pro Gln Asn Arg Tyr Ala
         260                 265                 270

 ctt ata tgt cag cag tgt ttt tct cat aat ggc atg gct ttg aag gaa     1041
 Leu Ile Cys Gln Gln Cys Phe Ser His Asn Gly Met Ala Leu Lys Glu
     275                 280                 285

 gaa ttt gaa tac att gct ttt cga tgt gcc tac tgt ttt ttc ttg aac     1089
 Glu Phe Glu Tyr Ile Ala Phe Arg Cys Ala Tyr Cys Phe Phe Leu Asn
 290                 295                 300                 305

 cct gca aga aaa acc aga cct cag gct cca aga ctt cct gag ttt agt     1137
 Pro Ala Arg Lys Thr Arg Pro Gln Ala Pro Arg Leu Pro Glu Phe Ser
                 310                 315                 320

 ttt gag aag agg cag gtg gtg gaa ggt tca agt tca gtt ggt ccc ttg     1185
 Phe Glu Lys Arg Gln Val Val Glu Gly Ser Ser Ser Val Gly Pro Leu
             325                 330                 335

 cca tca gga agt gtg ctt tca tca gac aac cag ttt aat gaa gaa tct     1233
 Pro Ser Gly Ser Val Leu Ser Ser Asp Asn Gln Phe Asn Glu Glu Ser
         340                 345                 350

 tta gaa cac gat gtt ctt gat gat aat aca gag cag aca gat gac aaa     1281
 Leu Glu His Asp Val Leu Asp Asp Asn Thr Glu Gln Thr Asp Asp Lys
     355                 360                 365

 ata cca gct aca gaa cag aca aac caa gtg att gaa aaa gca tct gac     1329
 Ile Pro Ala Thr Glu Gln Thr Asn Gln Val Ile Glu Lys Ala Ser Asp
 370                 375                 380                 385

 tca gag gaa cca gag gag aaa caa gag act gag aat gag gaa gcc tca     1377
 Ser Glu Glu Pro Glu Glu Lys Gln Glu Thr Glu Asn Glu Glu Ala Ser
                 390                 395                 400

 gtg att gaa acc aac tcc aca gtt cct gga gct gat tct att cct gat     1425
 Val Ile Glu Thr Asn Ser Thr Val Pro Gly Ala Asp Ser Ile Pro Asp
             405                 410                 415

 cct gaa cta agt gga gaa tct ttg acg gca gag tag taaa tgcttccacg     1475
 Pro Glu Leu Ser Gly Glu Ser Leu Thr Ala Glu 
         420                 425

 tgccttcaac tggatattta tagtcttact gatgtcagtt attgcttttt cggtggcact   1535

 tacttttttt gcccctctaa gggtatgctt gtgtatcatt tgaattcaga ttgcctagct   1595

 atttgaacat ctcaaagtta tatatactgg gtattaaaat taaaagcaag ttatatcagt   1655

 gaagtaagat ccttttgaat gtacaaagac ccacactatt gagacagctt ttagatactt   1715

 ttttgtccat tctaaaagta agcaaacatg attgccttct tgttttctgt atgtataacc   1775

 cgtaaatatc cattttgaca taggaagaac tttggttaag agtaagttct ctaattgtgt   1835

 ttgttttaag gaatgaaact tggttaagat tttgactact tcattattaa aaattgatag   1895

 aattttagct cctgagatat ttacaactgg gagaaatgtc tatttaggtg tttacattaa   1955

 gcggtatgaa agttgttacc acataggcac tggtacgaat tctcaataag aatgcagtgg   2015

 aacagttaag tagaactgta actacgttgg cactggtacg aattctcagt gagaatgcaa   2075

 tgaaacagtc aactgcagtg tttctttttg atgtctttta ttttacaact gggccaaagg   2135

 cacattatgt atataattag tttatattta cacactagca tataggaaat atttctgcac   2195

 ttgaccctat ttgaattctg agcattattt ataagtataa aatgatgata tataagtgaa   2255

 ttttgtgctc ttgtttgtat tttattaagg aaaatgaaaa taatctggca tcagtttcat   2315

 tttgctaaat atctagtctt cttcaaacag tatcttggtg ggtgacttgg ctacctgaaa   2375

 aatcttagga ggaatagctc acaatacaat aaatctgtag attctgctta gagcaaatta   2435

 tggtactttt attcagactt gtttcctttc tagttaacag aaatagtgac atttagaggt   2495

 tttaatcaga agttaggttt ttctgattca ggaacatcgt aggccagcca tttgtaattt   2555

 ttaactttga gaaacaaatt ttgtgagaat aggtagtggg ttgctggtag ttaattggat   2615

 ttaatatttg tattaaggat taactggaaa aaatgtgtct cagtgctaat tcttggacct   2675

 ttaatacagt gtgcttatct gttacggcct ccttttatct ctcttctcca atattaaaaa   2735

 aaatggaaat caaattatta tgctgaaggg aaaaatatac ctgtataaga aaaaaaaaaa   2795

 a                                                                   2796




      <210> 202
      <211> 2200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (424)..(1812)

      <400> 202
 gaatttcggc acgagagcta ttgtgttttt aaggatgcca caggcacaaa cgggggaata     60

 tgccctcctt ttttaacatg ggggggtgtt tttagaccag tccaacatta ggaatttctc    120

 ttgcttaaat taaaggtgct ccagacaaat taaacatcca aatctggtat atccaggtac    180

 ccgtgattcc tttggcaagg gtagtttctt ggaggggaag atcgattaat tttttcggag    240

 aaggaaagag aattaccaga ctgaactgtt gggaacaatt ggctgagcaa cgagggaaca    300

 agcgacggta atgaaagaga aaaagattta gaactcaggg ttgcagcgtc tggagcacaa    360

 gaccctgaga aatcgcctga tagactaaag cagtttagtg tggcaccaag acactttgaa    420

 gag  atg ata cca cct gaa aga ccc aga ata gct ttc cag aca cct ctc     468
      Met Ile Pro Pro Glu Arg Pro Arg Ile Ala Phe Gln Thr Pro Leu
        1               5                  10                  15

 ccg cct tta tct gcc cca tct gtc cca ccc atc cca tca gtt cat cct      516
 Pro Pro Leu Ser Ala Pro Ser Val Pro Pro Ile Pro Ser Val His Pro
                  20                  25                  30

 gtt cct tct caa aat gaa gat ttg cgc agt gga ctc agc agc gcc ctt      564
 Val Pro Ser Gln Asn Glu Asp Leu Arg Ser Gly Leu Ser Ser Ala Leu
              35                  40                  45

 ggt gaa atg gtg tct ccc agg att gca cct ctg cct cca cct ccc cta      612
 Gly Glu Met Val Ser Pro Arg Ile Ala Pro Leu Pro Pro Pro Pro Leu
          50                  55                  60

 cta cca cct ttg gct act aac tat cga act cct tat gat gat gca tac      660
 Leu Pro Pro Leu Ala Thr Asn Tyr Arg Thr Pro Tyr Asp Asp Ala Tyr
      65                  70                  75

 tat ttt tat ggg tcc agg aat act ttc gat ccc agt ctt gct tat tat      708
 Tyr Phe Tyr Gly Ser Arg Asn Thr Phe Asp Pro Ser Leu Ala Tyr Tyr
  80                  85                  90                  95

 ggt tca gga atg atg ggc gta cag cct gca gct tat gtt agt gct cct      756
 Gly Ser Gly Met Met Gly Val Gln Pro Ala Ala Tyr Val Ser Ala Pro
                 100                 105                 110

 gtc acc cac caa cta gca caa cct gtt gtg aat acg gtt gga cag aat      804
 Val Thr His Gln Leu Ala Gln Pro Val Val Asn Thr Val Gly Gln Asn
             115                 120                 125

 gaa ctg aag att aca agt gat caa gtg ata aat tca gga ttg att ttt      852
 Glu Leu Lys Ile Thr Ser Asp Gln Val Ile Asn Ser Gly Leu Ile Phe
         130                 135                 140

 gaa gat aaa ccg aaa cct tcc aaa cag tca ctt cag tct tac caa gag      900
 Glu Asp Lys Pro Lys Pro Ser Lys Gln Ser Leu Gln Ser Tyr Gln Glu
     145                 150                 155

 gct ttg cag cag cag att cgg gaa aga gaa gaa aga agg aag aaa gaa      948
 Ala Leu Gln Gln Gln Ile Arg Glu Arg Glu Glu Arg Arg Lys Lys Glu
 160                 165                 170                 175

 cgt gaa gaa aaa gaa gaa tat gaa gct aaa tta gaa gct gaa atg aga      996
 Arg Glu Glu Lys Glu Glu Tyr Glu Ala Lys Leu Glu Ala Glu Met Arg
                 180                 185                 190

 aca tat aat ccc tgg gga aaa ggt gga ggt ggt gct cct ctc agg gat     1044
 Thr Tyr Asn Pro Trp Gly Lys Gly Gly Gly Gly Ala Pro Leu Arg Asp
             195                 200                 205

 gca aaa gga aat ctg ata act gat ttg aat agg atg cac aga caa aat     1092
 Ala Lys Gly Asn Leu Ile Thr Asp Leu Asn Arg Met His Arg Gln Asn
         210                 215                 220

 ata gat gcc tac cat aac cca gat gca aga aca tat gaa gat aaa agg     1140
 Ile Asp Ala Tyr His Asn Pro Asp Ala Arg Thr Tyr Glu Asp Lys Arg
     225                 230                 235

 gct gtt gta tct cta gac cca aat tta gcc act tca aat gct gag aac     1188
 Ala Val Val Ser Leu Asp Pro Asn Leu Ala Thr Ser Asn Ala Glu Asn
 240                 245                 250                 255

 cta gaa gat gct gca aat aaa agc tca ggt cat atg caa aca cag agc     1236
 Leu Glu Asp Ala Ala Asn Lys Ser Ser Gly His Met Gln Thr Gln Ser
                 260                 265                 270

 tct cct ttt gct cgg gga aat gta ttt ggt gag cct cca act gaa ctt     1284
 Ser Pro Phe Ala Arg Gly Asn Val Phe Gly Glu Pro Pro Thr Glu Leu
             275                 280                 285

 cag att aaa cag caa gaa tta tac aag aat ttt ctt cgt ttc cag att     1332
 Gln Ile Lys Gln Gln Glu Leu Tyr Lys Asn Phe Leu Arg Phe Gln Ile
         290                 295                 300

 gag gaa aag aaa caa aga gag gaa gca gag cga gag aga ctg aga att     1380
 Glu Glu Lys Lys Gln Arg Glu Glu Ala Glu Arg Glu Arg Leu Arg Ile
     305                 310                 315

 gca gaa gaa aaa gaa gaa aga cgg ctt gca gaa cag agg gca cga att     1428
 Ala Glu Glu Lys Glu Glu Arg Arg Leu Ala Glu Gln Arg Ala Arg Ile
 320                 325                 330                 335

 cag cag gag tat gaa gag gaa cag gaa aag aaa aga gag aaa gag gag     1476
 Gln Gln Glu Tyr Glu Glu Glu Gln Glu Lys Lys Arg Glu Lys Glu Glu
                 340                 345                 350

 gag caa agg cta aaa aat gaa gag cat att cgg tta gct gaa gaa aga     1524
 Glu Gln Arg Leu Lys Asn Glu Glu His Ile Arg Leu Ala Glu Glu Arg
             355                 360                 365

 caa aaa gaa gca gaa aga aag aag aaa gaa gaa gaa gaa aaa tat aac     1572
 Gln Lys Glu Ala Glu Arg Lys Lys Lys Glu Glu Glu Glu Lys Tyr Asn
         370                 375                 380

 ctg caa ctt cag cac tac tgt gaa aga gac aat ttg att ggg gaa gaa     1620
 Leu Gln Leu Gln His Tyr Cys Glu Arg Asp Asn Leu Ile Gly Glu Glu
     385                 390                 395

 aca aag cac atg aga cag cct tct cct ata gtt cct gct ctt cag aac     1668
 Thr Lys His Met Arg Gln Pro Ser Pro Ile Val Pro Ala Leu Gln Asn
 400                 405                 410                 415

 aaa att gca agc aaa ctc caa aga cct cct tca gtt gac agc atc ata     1716
 Lys Ile Ala Ser Lys Leu Gln Arg Pro Pro Ser Val Asp Ser Ile Ile
                 420                 425                 430

 cgt tcc ttt att cat gaa agt tcc gtt gaa gcc gtc gac ggc ttc aac     1764
 Arg Ser Phe Ile His Glu Ser Ser Val Glu Ala Val Asp Gly Phe Asn
             435                 440                 445

 gga act tta cac gtg att ctt ctg cac aca gta ttg aag agc aac tag     1812
 Gly Thr Leu His Val Ile Leu Leu His Thr Val Leu Lys Ser Asn 
         450                 455                 460

 attaaattct agtttacaaa attaccagtt ttcttcaaga actaaatgat atgtcctttt   1872

 ttttttttca aaaaggaaaa gggcggcttt taaaaaaaaa aaccaaaggg aaagggaaaa   1932

 ggggacccgg ttcattccac caccttttta attggccccg gattggcccc ccacccggcg   1992

 gcctttggat tggattcggg gacccagaac tttaaatcgg ttaccaaaca atccggggtt   2052

 aaaccccaaa agggccaaac cggcaaaagg gcggcgggta aacaatccaa aaagccttgg   2112

 gaccggggcc aaagtgaaag aaggaactta aaaaaaccgg ttcttaaacc tcttaaaact   2172

 taaaaaacct tggttaaaaa aaaaaaaa                                      2200




      <210> 203
      <211> 2000
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1738)

      <400> 203
 tttcgtggag cgcaggcagc agcactttat ctgcgactct ccagcccagc gagaggcgaa     60

 gcggtttacc   atg gaa ccc gtg acc aag tgg agc ccc aaa caa gtg gtg     109
              Met Glu Pro Val Thr Lys Trp Ser Pro Lys Gln Val Val
                1               5                  10

 gac tgg act aga ggg ttg gat gac tgc ctg caa caa tat gtc cac aag      157
 Asp Trp Thr Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys
      15                  20                  25

 ttt gaa cga gag aag atc aac ggc gag cag ctg ctg cag att tcc cat      205
 Phe Glu Arg Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His
  30                  35                  40                  45

 cag gac ctg gag gag ctg ggg gtc aca cgg atc gga cac cag gag ctt      253
 Gln Asp Leu Glu Glu Leu Gly Val Thr Arg Ile Gly His Gln Glu Leu
                  50                  55                  60

 gtg ttg gag gct gtg gac ctt ctc tgt gca ctg aat tat ggc ctc gaa      301
 Val Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu
              65                  70                  75

 act gat aac atg aag aac ttg gtt ctg aaa ctg aga gca tct tcc cac      349
 Thr Asp Asn Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His
          80                  85                  90

 aat tta cag aat tac ata agt agc cga cgg aaa agt ccc gct tac gat      397
 Asn Leu Gln Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp
      95                 100                 105

 ggc aac acc tcc cgc aag gcc ccc aat gag ttc ctg acc tcg gtg gtg      445
 Gly Asn Thr Ser Arg Lys Ala Pro Asn Glu Phe Leu Thr Ser Val Val
 110                 115                 120                 125

 gag ctc atc ggc gcc gcc aag gcc ctg ctg gcg tgg ctg gac cgg gct      493
 Glu Leu Ile Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala
                 130                 135                 140

 ccg ttt aca ggg atc act gat ttc tca gtc acg aag aac aaa att atc      541
 Pro Phe Thr Gly Ile Thr Asp Phe Ser Val Thr Lys Asn Lys Ile Ile
             145                 150                 155

 cag ctt tgc ttg gac ctg acc act aca gtc cag aag gat tgc ttt gta      589
 Gln Leu Cys Leu Asp Leu Thr Thr Thr Val Gln Lys Asp Cys Phe Val
         160                 165                 170

 gcg gaa atg gag gat aaa gtt tta act gtg gtc aag gtt tta aat ggc      637
 Ala Glu Met Glu Asp Lys Val Leu Thr Val Val Lys Val Leu Asn Gly
     175                 180                 185

 atc tgt gac aaa aca atc cga tct acc aca gat cct gtg atg agc cag      685
 Ile Cys Asp Lys Thr Ile Arg Ser Thr Thr Asp Pro Val Met Ser Gln
 190                 195                 200                 205

 tgt gca tgt ctg gag gaa gtt cac tta cca aac att aaa cct ggg gaa      733
 Cys Ala Cys Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu
                 210                 215                 220

 ggc ctg ggc atg tac atc aaa tca acc tat gat ggg tta cac gtg att      781
 Gly Leu Gly Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu His Val Ile
             225                 230                 235

 act gga acc aca gaa aat tct cct gca gac aga tct cag aag att cat      829
 Thr Gly Thr Thr Glu Asn Ser Pro Ala Asp Arg Ser Gln Lys Ile His
         240                 245                 250

 gct ggt gac gaa gtc att caa gtt aat cag caa act gtg gtg gga tgg      877
 Ala Gly Asp Glu Val Ile Gln Val Asn Gln Gln Thr Val Val Gly Trp
     255                 260                 265

 cag ctg aaa aat ctg gtg aag aaa ttg aga gag aat ccc acc gga gtt      925
 Gln Leu Lys Asn Leu Val Lys Lys Leu Arg Glu Asn Pro Thr Gly Val
 270                 275                 280                 285

 gtg tta ctg ctt aag aag cgc ccc acc ggg tct ttc aac ttt act cct      973
 Val Leu Leu Leu Lys Lys Arg Pro Thr Gly Ser Phe Asn Phe Thr Pro
                 290                 295                 300

 gct ccc ctg aaa aac cta cgg tgg aag cca cct ctt gta cag acc tca     1021
 Ala Pro Leu Lys Asn Leu Arg Trp Lys Pro Pro Leu Val Gln Thr Ser
             305                 310                 315

 cct cca ccc gcg aca acc cag tcc cct gaa agc act atg gat acc tca     1069
 Pro Pro Pro Ala Thr Thr Gln Ser Pro Glu Ser Thr Met Asp Thr Ser
         320                 325                 330

 ctg aag aag gag aag tca gcc atc ctg gat ctt tat att cct cct ccg     1117
 Leu Lys Lys Glu Lys Ser Ala Ile Leu Asp Leu Tyr Ile Pro Pro Pro
     335                 340                 345

 cct gct gtt ccc tac tct ccc cgg gat gag aat ggc agt ttt gtt tat     1165
 Pro Ala Val Pro Tyr Ser Pro Arg Asp Glu Asn Gly Ser Phe Val Tyr
 350                 355                 360                 365

 gga ggg tcc agt aag tgc aaa caa cca ttg cct ggt cct aag ggt tca     1213
 Gly Gly Ser Ser Lys Cys Lys Gln Pro Leu Pro Gly Pro Lys Gly Ser
                 370                 375                 380

 gag tcc ccg aat tcc ttc ttg gac cag gaa agc cgg aga cga aga ttc     1261
 Glu Ser Pro Asn Ser Phe Leu Asp Gln Glu Ser Arg Arg Arg Arg Phe
             385                 390                 395

 acc att gca gac tcg gat cag ttg cct ggg tac tcg gtg gaa acc aac     1309
 Thr Ile Ala Asp Ser Asp Gln Leu Pro Gly Tyr Ser Val Glu Thr Asn
         400                 405                 410

 att ctg ccc aca aaa atg aga gag aaa aca cca tct tat ggc aag cca     1357
 Ile Leu Pro Thr Lys Met Arg Glu Lys Thr Pro Ser Tyr Gly Lys Pro
     415                 420                 425

 cgg cct ttg tcc atg cct gct gat ggg aac tgg atg ggg att gtg gac     1405
 Arg Pro Leu Ser Met Pro Ala Asp Gly Asn Trp Met Gly Ile Val Asp
 430                 435                 440                 445

 cct ttt gcc aga cct cga ggt cat ggc agg aaa ggg gag gat gcc ctt     1453
 Pro Phe Ala Arg Pro Arg Gly His Gly Arg Lys Gly Glu Asp Ala Leu
                 450                 455                 460

 tgc cgg tat ttc agt aac gag cgg att cct ccg atc att gaa gag agc     1501
 Cys Arg Tyr Phe Ser Asn Glu Arg Ile Pro Pro Ile Ile Glu Glu Ser
             465                 470                 475

 tcc tct ccc cca tac cgg ttc tcc aga ccc acg acc gag cgg cat ctg     1549
 Ser Ser Pro Pro Tyr Arg Phe Ser Arg Pro Thr Thr Glu Arg His Leu
         480                 485                 490

 gtc cgg ggt gcg gac tac atc cga gga agc agg tgc tac atc aac tca     1597
 Val Arg Gly Ala Asp Tyr Ile Arg Gly Ser Arg Cys Tyr Ile Asn Ser
     495                 500                 505

 gat ctc cac agc agc gcc acg att cca ttc cag gag gaa ggg acc aaa     1645
 Asp Leu His Ser Ser Ala Thr Ile Pro Phe Gln Glu Glu Gly Thr Lys
 510                 515                 520                 525

 aag aaa tct ggc tcc tca gct acg aag tcc tcg tcc aca gaa ccg tcc     1693
 Lys Lys Ser Gly Ser Ser Ala Thr Lys Ser Ser Ser Thr Glu Pro Ser
                 530                 535                 540

 ctc ctg gtc agc tgg ttt acg cgc ctc aaa ctg ttg act cac tga gag     1741
 Leu Leu Val Ser Trp Phe Thr Arg Leu Lys Leu Leu Thr His 
             545                 550                 555

 ggaccctgct caggccacct gcctggctcc tgccccaagt gccttgcttt tacagtggac   1801

 agcctcttct cgtttcggcc tcagtattat gtagggacct tatgcaattt ctttttcttt   1861

 tgaaaagtta tctactgccc ttcttggaag tttgcaggat tggatgggaa caaattcaga   1921

 ggatcttagg tgttggcttg tggagacaaa aggagggaaa tgggtagagc ctgtttgtct   1981

 tgcttcccca gaatgtatt                                                2000




      <210> 204
      <211> 1234
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(781)

      <400> 204
 tttcgtggag cgcaggcagc agcactttat ctgcgactct ccagcccagc gagaggcgaa     60

 gcggtttacc   atg gaa ccc gtg acc aag tgg agc ccc aaa caa gtg gtg     109
              Met Glu Pro Val Thr Lys Trp Ser Pro Lys Gln Val Val
                1               5                  10

 gac tgg act aga ggg ttg gat gac tgc ctg caa caa tat gtc cac aag      157
 Asp Trp Thr Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys
      15                  20                  25

 ttt gaa cga gag aag atc aac ggc gag cag ctg ctg cag att tcc cat      205
 Phe Glu Arg Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His
  30                  35                  40                  45

 cag gac ctg gag gag ctg ggg gtc aca cgg atc gga cac cag gag ctt      253
 Gln Asp Leu Glu Glu Leu Gly Val Thr Arg Ile Gly His Gln Glu Leu
                  50                  55                  60

 gtg ttg gag gct gtg gac ctt ctc tgt gca ctg aat tat ggc ctc gaa      301
 Val Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu
              65                  70                  75

 act gat aac atg aag aac ttg gtt ctg aaa ctg aga gca tct tcc cac      349
 Thr Asp Asn Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His
          80                  85                  90

 aat tta cag aat tac ata agt agc cga cgg aaa agt ccc gct tac gat      397
 Asn Leu Gln Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp
      95                 100                 105

 ggc aac acc tcc cgc aag gcc ccc aat gag ttc ctg acc tcg gtg gtg      445
 Gly Asn Thr Ser Arg Lys Ala Pro Asn Glu Phe Leu Thr Ser Val Val
 110                 115                 120                 125

 gag ctc atc ggc gcc gcc aag gcc ctg ctg gcg tgg ctg gac cgg gct      493
 Glu Leu Ile Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala
                 130                 135                 140

 ccg ttt aca ggg atc act gat ttc tca gtc acg aag aac aaa att atc      541
 Pro Phe Thr Gly Ile Thr Asp Phe Ser Val Thr Lys Asn Lys Ile Ile
             145                 150                 155

 cag ctt tgc ttg gac ctg acc act aca gtc cag aag gat tgc ttt gta      589
 Gln Leu Cys Leu Asp Leu Thr Thr Thr Val Gln Lys Asp Cys Phe Val
         160                 165                 170

 gcg gaa atg gag gat aaa gtt tta act gtg gtc aag gtt tta aat ggc      637
 Ala Glu Met Glu Asp Lys Val Leu Thr Val Val Lys Val Leu Asn Gly
     175                 180                 185

 atc tgt gac aaa aca atc cga tct acc aca gat cct gtg atg agc cag      685
 Ile Cys Asp Lys Thr Ile Arg Ser Thr Thr Asp Pro Val Met Ser Gln
 190                 195                 200                 205

 tgt gcc ctc tgg aga gca gct ttg gtg ttt gcc aat aca gaa cac aaa      733
 Cys Ala Leu Trp Arg Ala Ala Leu Val Phe Ala Asn Thr Glu His Lys
                 210                 215                 220

 cag aaa tta atg cta atg gaa atg tct gat caa cta ttt ctc agg tag      781
 Gln Lys Leu Met Leu Met Glu Met Ser Asp Gln Leu Phe Leu Arg 
             225                 230                 235

 gcttttagaa ataaaactaa cagttgaaat aagatttaca aaaaccaagc actgaggtac    841

 ttccttagaa actagtcaca aagcggagaa tcagttctca tgggaatttc ctcctgagat    901

 ctttctctcc cattcctcag cccagcactg aaaccttggt agcggtgctg aagctgagta    961

 ggattgggag ggtgcaccaa gcctgcctcc aaaatagtgg tctccagttt atgttttaag   1021

 tgctactcta aatggaaaaa gtatgctgaa gagcctagac actgtatctc cactagaaat   1081

 cctggggaga gagagcggct gaaaacctag caaaggttgg ctcactggtg ccagccccag   1141

 gatgtcggag atgctgaaca tcatgttgag tgtgtgtctc ccagtgtgtc acagtagacg   1201

 aaatcgtcga cagcccggga attccggagc ggt                                1234




      <210> 205
      <211> 1931
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (71)..(1669)

      <400> 205
 tttcgtggag cgcaggcagc agcactttat ctgcgactct ccagcccagc gagaggcgaa     60

 gcggtttacc   atg gaa ccc gtg acc aag tgg agc ccc aaa caa gtg gtg     109
              Met Glu Pro Val Thr Lys Trp Ser Pro Lys Gln Val Val
                1               5                  10

 gac tgg act aga ggg ttg gat gac tgc ctg caa caa tat gtc cac aag      157
 Asp Trp Thr Arg Gly Leu Asp Asp Cys Leu Gln Gln Tyr Val His Lys
      15                  20                  25

 ttt gaa cga gag aag atc aac ggc gag cag ctg ctg cag att tcc cat      205
 Phe Glu Arg Glu Lys Ile Asn Gly Glu Gln Leu Leu Gln Ile Ser His
  30                  35                  40                  45

 cag gac ctg gag gag ctg ggg gtc aca cgg atc gga cac cag gag ctt      253
 Gln Asp Leu Glu Glu Leu Gly Val Thr Arg Ile Gly His Gln Glu Leu
                  50                  55                  60

 gtg ttg gag gct gtg gac ctt ctc tgt gca ctg aat tat ggc ctc gaa      301
 Val Leu Glu Ala Val Asp Leu Leu Cys Ala Leu Asn Tyr Gly Leu Glu
              65                  70                  75

 act gat aac atg aag aac ttg gtt ctg aaa ctg aga gca tct tcc cac      349
 Thr Asp Asn Met Lys Asn Leu Val Leu Lys Leu Arg Ala Ser Ser His
          80                  85                  90

 aat tta cag aat tac ata agt agc cga cgg aaa agt ccc gct tac gat      397
 Asn Leu Gln Asn Tyr Ile Ser Ser Arg Arg Lys Ser Pro Ala Tyr Asp
      95                 100                 105

 ggc aac acc tcc cgc aag gcc ccc aat gag ttc ctg acc tcg gtg gtg      445
 Gly Asn Thr Ser Arg Lys Ala Pro Asn Glu Phe Leu Thr Ser Val Val
 110                 115                 120                 125

 gag ctc atc ggc gcc gcc aag gcc ctg ctg gcg tgg ctg gac cgg gct      493
 Glu Leu Ile Gly Ala Ala Lys Ala Leu Leu Ala Trp Leu Asp Arg Ala
                 130                 135                 140

 ccg ttt aca ggg atc act gat ttc tca gtc acg aag aac aaa att atc      541
 Pro Phe Thr Gly Ile Thr Asp Phe Ser Val Thr Lys Asn Lys Ile Ile
             145                 150                 155

 cag ctt tgc ttg gac ctg acc act aca gtc cag aag gat tgc ttt gta      589
 Gln Leu Cys Leu Asp Leu Thr Thr Thr Val Gln Lys Asp Cys Phe Val
         160                 165                 170

 gcg gaa atg gag gat aaa gtt tta act gtg gtc aag gtt tta aat ggc      637
 Ala Glu Met Glu Asp Lys Val Leu Thr Val Val Lys Val Leu Asn Gly
     175                 180                 185

 atc tgt gac aaa aca atc cga tct acc aca gat cct gtg atg agc cag      685
 Ile Cys Asp Lys Thr Ile Arg Ser Thr Thr Asp Pro Val Met Ser Gln
 190                 195                 200                 205

 tgt gca tgt ctg gag gaa gtt cac tta cca aac att aaa cct ggg gaa      733
 Cys Ala Cys Leu Glu Glu Val His Leu Pro Asn Ile Lys Pro Gly Glu
                 210                 215                 220

 ggc ctg ggc atg tac atc aaa tca acc tat gat ggg tta cac gtg att      781
 Gly Leu Gly Met Tyr Ile Lys Ser Thr Tyr Asp Gly Leu His Val Ile
             225                 230                 235

 act gga acc aca gaa aat gtg gga tgg cag ctg aaa aat ctg gtg aag      829
 Thr Gly Thr Thr Glu Asn Val Gly Trp Gln Leu Lys Asn Leu Val Lys
         240                 245                 250

 aaa ttg aga gag aat ccc acc gga gtt gtg tta ctg ctt aag aag cgc      877
 Lys Leu Arg Glu Asn Pro Thr Gly Val Val Leu Leu Leu Lys Lys Arg
     255                 260                 265

 ccc acc ggg tct ttc aac ttt act cct gct ccc ctg aaa aac cta cgg      925
 Pro Thr Gly Ser Phe Asn Phe Thr Pro Ala Pro Leu Lys Asn Leu Arg
 270                 275                 280                 285

 tgg aag cca cct ctt gta cag acc tca cct cca ccc gcg aca acc cag      973
 Trp Lys Pro Pro Leu Val Gln Thr Ser Pro Pro Pro Ala Thr Thr Gln
                 290                 295                 300

 tcc cct gaa agc act atg gat acc tca ctg aag aag gag aag tca gcc     1021
 Ser Pro Glu Ser Thr Met Asp Thr Ser Leu Lys Lys Glu Lys Ser Ala
             305                 310                 315

 atc ctg gat ctt tat att cct cct ccg cct gct gtt ccc tac tct ccc     1069
 Ile Leu Asp Leu Tyr Ile Pro Pro Pro Pro Ala Val Pro Tyr Ser Pro
         320                 325                 330

 cgg gat gag aat ggc agt ttt gtt tat gga ggg tcc agt aag tgc aaa     1117
 Arg Asp Glu Asn Gly Ser Phe Val Tyr Gly Gly Ser Ser Lys Cys Lys
     335                 340                 345

 caa cca ttg cct ggt cct aag ggt tca gag tcc ccg aat tcc ttc ttg     1165
 Gln Pro Leu Pro Gly Pro Lys Gly Ser Glu Ser Pro Asn Ser Phe Leu
 350                 355                 360                 365

 gac cag gaa agc cgg aga cga aga ttc acc att gca gac tcg gat cag     1213
 Asp Gln Glu Ser Arg Arg Arg Arg Phe Thr Ile Ala Asp Ser Asp Gln
                 370                 375                 380

 ttg cct ggg tac tcg gtg gaa acc aac att ctg ccc aca aaa atg aga     1261
 Leu Pro Gly Tyr Ser Val Glu Thr Asn Ile Leu Pro Thr Lys Met Arg
             385                 390                 395

 gag aaa aca cca tct tat ggc aag cca cgg cct ttg tcc atg cct gct     1309
 Glu Lys Thr Pro Ser Tyr Gly Lys Pro Arg Pro Leu Ser Met Pro Ala
         400                 405                 410

 gat ggg aac tgg atg ggg att gtg gac cct ttt gcc aga cct cga ggt     1357
 Asp Gly Asn Trp Met Gly Ile Val Asp Pro Phe Ala Arg Pro Arg Gly
     415                 420                 425

 cat ggc agg aaa ggg gag gat gcc ctt tgc cgg tat ttc agt aac gag     1405
 His Gly Arg Lys Gly Glu Asp Ala Leu Cys Arg Tyr Phe Ser Asn Glu
 430                 435                 440                 445

 cgg att cct ccg atc att gaa gag agc tcc tct ccc cca tac cgg ttc     1453
 Arg Ile Pro Pro Ile Ile Glu Glu Ser Ser Ser Pro Pro Tyr Arg Phe
                 450                 455                 460

 tcc aga ccc acg acc gag cgg cat ctg gtc cgg ggt gcg gac tac atc     1501
 Ser Arg Pro Thr Thr Glu Arg His Leu Val Arg Gly Ala Asp Tyr Ile
             465                 470                 475

 cga gga agc agg tgc tac atc aac tca gat ctc cac agc agc gcc acg     1549
 Arg Gly Ser Arg Cys Tyr Ile Asn Ser Asp Leu His Ser Ser Ala Thr
         480                 485                 490

 att cca ttc cag gag gaa ggg acc aaa aag aaa tct ggc tcc tca gct     1597
 Ile Pro Phe Gln Glu Glu Gly Thr Lys Lys Lys Ser Gly Ser Ser Ala
     495                 500                 505

 acg aag tcc tcg tcc aca gaa ccg tcc ctc ctg gtc agc tgg ttt acg     1645
 Thr Lys Ser Ser Ser Thr Glu Pro Ser Leu Leu Val Ser Trp Phe Thr
 510                 515                 520                 525

 cgc ctc aaa ctg ttg act cac tga gagggaccct gctcaggcca cctgcctggc    1699
 Arg Leu Lys Leu Leu Thr His 
                 530

 tcctgcccca agtgccttgc ttttacagtg gacagcctct tctcgtttcg gcctcagtat   1759

 tatgtaggga ccttatgcaa tttctttttc ttttgaaaag ttatctactg cccttcttgg   1819

 aagtttgcag gattggatgg gaacaaattc agaggatctt aggtgttggc ttgtggagac   1879

 aaaaggaggg aaatgggtag agcctgtttg tcttgcttcc ccagaatgta tt           1931




      <210> 206
      <211> 6736
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (827)..(6172)

      <220>
      <221> misc_feature
      <222> (1)...(6736)
      <223> n = a,t,c or g

      <400> 206
 gcagtccatg gagcataacc tagccctggt ggcctagaag gaaggaaggg caggcagagt     60

 gtagatagtt cattctgcct tgagttggtg gggttagtga taaccctgct gtcttttgcc    120

 ttaggagaga aacaagaatg ctgctcagga gctggccact ttgctgttgt ccctgccagc    180

 acctgccagt gtccagcagc agtccaagag ccttctggcc agcctgcaca ccagccgctc    240

 ggcctaccac agccacaagg taactgttct ctcagggaaa ggaaattgca gtgctgacag    300

 ggaatcaaat aagttagctt ttcattgtaa agcaacagca cagcaaagta aggtagaggg    360

 aggatagcat tcagattaga cctacatttt acagagtttc tcctgagana ttctcaagtg    420

 ccactcanaa ccgagggtaa gccagtgact gggcccctgg tttgtactta tttttctgtc    480

 actctaacag gatcaacaag acttaagaaa gagaaggagg gatattgagc acgatgacag    540

 tgagcctatt ttggggcaat ggtttgagga gactatttct cccagtaaag agaaagcagc    600

 acctccgcct cctcccccac ctcctccact ggaaagctct cctcgggtta aaagccccag    660

 taagcaggcc cctggtgaga agggcaacat tctggcgagt cgcaaagatc ctgagttgtt    720

 cttaggtctg gcttccaaca ttttgaactt catcacctct tccatgctga actctcggaa    780

 caattttatc cgaaactatc tgagtgtatc tctttcagaa caccat   atg gcc acc     835
                                                      Met Ala Thr
                                                        1

 cta gcc agt atc atc aag gag gtg gac aaa gat gga ctc aag ggt tca      883
 Leu Ala Ser Ile Ile Lys Glu Val Asp Lys Asp Gly Leu Lys Gly Ser
       5                  10                  15

 tca gat gaa gag ttt gct gca gct ctc tat cac ttc aac cac tca ctg      931
 Ser Asp Glu Glu Phe Ala Ala Ala Leu Tyr His Phe Asn His Ser Leu
  20                  25                  30                  35

 gta acc tct gac ctt cag tca cct aac ctg cag aac aca ctg ttg cag      979
 Val Thr Ser Asp Leu Gln Ser Pro Asn Leu Gln Asn Thr Leu Leu Gln
                  40                  45                  50

 cag cta gga gtg gct cct ttt tct gag ggc cct tgg ccc ttg tac att     1027
 Gln Leu Gly Val Ala Pro Phe Ser Glu Gly Pro Trp Pro Leu Tyr Ile
              55                  60                  65

 cac cct caa agc ctc tct gtg ctt tca cgc ctc ctg ctc atc tgg caa     1075
 His Pro Gln Ser Leu Ser Val Leu Ser Arg Leu Leu Leu Ile Trp Gln
          70                  75                  80

 cat aaa gcc agt gct caa ggt gac cct gac gtc cca gaa tgc ctt aaa     1123
 His Lys Ala Ser Ala Gln Gly Asp Pro Asp Val Pro Glu Cys Leu Lys
      85                  90                  95

 gtt tgg gac agg ttt ttg tct aca atg aag cag aat gcc ctg caa ggt     1171
 Val Trp Asp Arg Phe Leu Ser Thr Met Lys Gln Asn Ala Leu Gln Gly
 100                 105                 110                 115

 gtg gtg ccc agt gag aca gag gat ctg aat gta gaa cac ctg cag atg     1219
 Val Val Pro Ser Glu Thr Glu Asp Leu Asn Val Glu His Leu Gln Met
                 120                 125                 130

 ctc ctc ctc att ttc cac aat ttc acc gag aca ggc cgg cgg gcc ata     1267
 Leu Leu Leu Ile Phe His Asn Phe Thr Glu Thr Gly Arg Arg Ala Ile
             135                 140                 145

 ttg tcg ctt ttt gtc cag atc atc cag gag ttg agc gtc aac atg gat     1315
 Leu Ser Leu Phe Val Gln Ile Ile Gln Glu Leu Ser Val Asn Met Asp
         150                 155                 160

 gct cag atg cgc ttc gtg ccg ctt atc ttg gct cgc ctc ctt ctc atc     1363
 Ala Gln Met Arg Phe Val Pro Leu Ile Leu Ala Arg Leu Leu Leu Ile
     165                 170                 175

 ttt gat tat ctg ctt cat cag tac tcc aaa gcc cct gtg tat cta ttt     1411
 Phe Asp Tyr Leu Leu His Gln Tyr Ser Lys Ala Pro Val Tyr Leu Phe
 180                 185                 190                 195

 gag cag gta cag cat aac ctg cta agt cct ccc ttt ggg tgg gca agt     1459
 Glu Gln Val Gln His Asn Leu Leu Ser Pro Pro Phe Gly Trp Ala Ser
                 200                 205                 210

 gga tcc cag gac agc aac agc cgc cgg gca acc act cct ctc tat cat     1507
 Gly Ser Gln Asp Ser Asn Ser Arg Arg Ala Thr Thr Pro Leu Tyr His
             215                 220                 225

 gga ttc aaa gaa gta gaa gaa aac tgg tct aag cat ttc tca tca gat     1555
 Gly Phe Lys Glu Val Glu Glu Asn Trp Ser Lys His Phe Ser Ser Asp
         230                 235                 240

 gct gtc cca cac ccc aga ttc tac tgt gtc ctg tcc cca gaa gcc tca     1603
 Ala Val Pro His Pro Arg Phe Tyr Cys Val Leu Ser Pro Glu Ala Ser
     245                 250                 255

 gag gat gat ttg aac cga ctt gat tct gtg gca tgt gac gtc ctt ttt     1651
 Glu Asp Asp Leu Asn Arg Leu Asp Ser Val Ala Cys Asp Val Leu Phe
 260                 265                 270                 275

 tcc aag ctt gtc aag tat gat gag ctt tat gct gca ctg aca gcc ctg     1699
 Ser Lys Leu Val Lys Tyr Asp Glu Leu Tyr Ala Ala Leu Thr Ala Leu
                 280                 285                 290

 ctt gca gct ggg tcc cag ctt gat aca gtt agg aga aag gaa aac aag     1747
 Leu Ala Ala Gly Ser Gln Leu Asp Thr Val Arg Arg Lys Glu Asn Lys
             295                 300                 305

 aat gta aca gcc ttg gag gcc tgt gcc ctt caa tat tac ttc ttg ata     1795
 Asn Val Thr Ala Leu Glu Ala Cys Ala Leu Gln Tyr Tyr Phe Leu Ile
         310                 315                 320

 ctg tgg agg atc cta gga att tta cca cca tca aag act tac att aac     1843
 Leu Trp Arg Ile Leu Gly Ile Leu Pro Pro Ser Lys Thr Tyr Ile Asn
     325                 330                 335

 cag cta tcc atg aac tca cct gag atg agc gaa tgt gac atc ttg cac     1891
 Gln Leu Ser Met Asn Ser Pro Glu Met Ser Glu Cys Asp Ile Leu His
 340                 345                 350                 355

 act ctg cga tgg tct tct cgg ctc cgg atc agc tcc tat gtc aac tgg     1939
 Thr Leu Arg Trp Ser Ser Arg Leu Arg Ile Ser Ser Tyr Val Asn Trp
                 360                 365                 370

 ata aag gat cac ctt atc aaa cag gga atg aag gct gag cat gct agc     1987
 Ile Lys Asp His Leu Ile Lys Gln Gly Met Lys Ala Glu His Ala Ser
             375                 380                 385

 tcg ctt cta gaa ctg gca tcc acc act aag tgt agc tca gtg aaa tat     2035
 Ser Leu Leu Glu Leu Ala Ser Thr Thr Lys Cys Ser Ser Val Lys Tyr
         390                 395                 400

 gat gtt gaa ata gta gag gaa tac ttc gct cga cag atc tca tcc ttc     2083
 Asp Val Glu Ile Val Glu Glu Tyr Phe Ala Arg Gln Ile Ser Ser Phe
     405                 410                 415

 tgt agt atc gac tgt acc acc atc ttg cag ctg cat gaa att ccc agt     2131
 Cys Ser Ile Asp Cys Thr Thr Ile Leu Gln Leu His Glu Ile Pro Ser
 420                 425                 430                 435

 ctg cag tcc atc tac acc ctt gat gcc gcg atc tca aag gtc cag gtc     2179
 Leu Gln Ser Ile Tyr Thr Leu Asp Ala Ala Ile Ser Lys Val Gln Val
                 440                 445                 450

 tct ttg gat gag cat ttt tct aag atg gct gct gag act gat cct cat     2227
 Ser Leu Asp Glu His Phe Ser Lys Met Ala Ala Glu Thr Asp Pro His
             455                 460                 465

 aag tcg tct gag att acc aag aac cta ctt cca gcc acg ctg caa ctc     2275
 Lys Ser Ser Glu Ile Thr Lys Asn Leu Leu Pro Ala Thr Leu Gln Leu
         470                 475                 480

 att gac acc tat gca tcg ttc acc aga gcc tat ttg ctg caa aac ttt     2323
 Ile Asp Thr Tyr Ala Ser Phe Thr Arg Ala Tyr Leu Leu Gln Asn Phe
     485                 490                 495

 aat gaa gag gga aca act gag aaa cct tcc aag gag aaa ctg caa ggc     2371
 Asn Glu Glu Gly Thr Thr Glu Lys Pro Ser Lys Glu Lys Leu Gln Gly
 500                 505                 510                 515

 ttt gct gct gtt ttg gct att ggc tct agc agg tgc aag gca aat act     2419
 Phe Ala Ala Val Leu Ala Ile Gly Ser Ser Arg Cys Lys Ala Asn Thr
                 520                 525                 530

 ctg ggt ccg aca ctg gtt cag aat ttg cca tcg tca gtg cag act gtg     2467
 Leu Gly Pro Thr Leu Val Gln Asn Leu Pro Ser Ser Val Gln Thr Val
             535                 540                 545

 tgt gag tcc tgg aac aac atc aat acc aat gaa ttt ccc aat att gga     2515
 Cys Glu Ser Trp Asn Asn Ile Asn Thr Asn Glu Phe Pro Asn Ile Gly
         550                 555                 560

 tcc tgg cgc aat gcc ttt gcc aat gac acc atc cct tca gag agt tat     2563
 Ser Trp Arg Asn Ala Phe Ala Asn Asp Thr Ile Pro Ser Glu Ser Tyr
     565                 570                 575

 att agt gca gtg cag gct gca cac ctg ggg act ctc tgt agc caa agt     2611
 Ile Ser Ala Val Gln Ala Ala His Leu Gly Thr Leu Cys Ser Gln Ser
 580                 585                 590                 595

 ctg ccc ctg gct gct tcc ctg aag cat acc ctc ctc tca ctg gtc agg     2659
 Leu Pro Leu Ala Ala Ser Leu Lys His Thr Leu Leu Ser Leu Val Arg
                 600                 605                 610

 ttg act gga gat ctt att gtt tgg tca gat gag atg aac cca cca cag     2707
 Leu Thr Gly Asp Leu Ile Val Trp Ser Asp Glu Met Asn Pro Pro Gln
             615                 620                 625

 gta att cgg aca ctg cta cct ctt ctt ttg gaa tca agc act gag agt     2755
 Val Ile Arg Thr Leu Leu Pro Leu Leu Leu Glu Ser Ser Thr Glu Ser
         630                 635                 640

 gtt gcc gag atc agt agc aac tcc ctg gaa cgc atc ttg ggc cct gct     2803
 Val Ala Glu Ile Ser Ser Asn Ser Leu Glu Arg Ile Leu Gly Pro Ala
     645                 650                 655

 gag tct gat gag ttc ttg gct cgt gtt tat gag aag ctg atc act ggt     2851
 Glu Ser Asp Glu Phe Leu Ala Arg Val Tyr Glu Lys Leu Ile Thr Gly
 660                 665                 670                 675

 tgt tac aac att ctg gcc aat cat gca gat cct aac agt gga ctg gat     2899
 Cys Tyr Asn Ile Leu Ala Asn His Ala Asp Pro Asn Ser Gly Leu Asp
                 680                 685                 690

 gaa tcc atc ctg gag gaa tgt ctc cag tac ttg gaa aag cag ctg gaa     2947
 Glu Ser Ile Leu Glu Glu Cys Leu Gln Tyr Leu Glu Lys Gln Leu Glu
             695                 700                 705

 agt agc cag gct cgt aaa gct atg gag gag ttt ttc tct gac agt gga     2995
 Ser Ser Gln Ala Arg Lys Ala Met Glu Glu Phe Phe Ser Asp Ser Gly
         710                 715                 720

 gaa ctt gta cag atc atg atg gca aca gcc aat gag aac ctc tct gct     3043
 Glu Leu Val Gln Ile Met Met Ala Thr Ala Asn Glu Asn Leu Ser Ala
     725                 730                 735

 aaa ttc tgt aac cga gtt ttg aaa ttc ttc acc aaa ctc ttc cag ctg     3091
 Lys Phe Cys Asn Arg Val Leu Lys Phe Phe Thr Lys Leu Phe Gln Leu
 740                 745                 750                 755

 act gag aag agc cct aac ccg agc ctg ttg cat ctt tgt ggc tcc ctg     3139
 Thr Glu Lys Ser Pro Asn Pro Ser Leu Leu His Leu Cys Gly Ser Leu
                 760                 765                 770

 gca caa ctg gcc tgt gtg gaa cct gtg cgc ctg cag gcc tgg ctc acc     3187
 Ala Gln Leu Ala Cys Val Glu Pro Val Arg Leu Gln Ala Trp Leu Thr
             775                 780                 785

 cgc atg act aca tcg ccc cca aaa gat tct gat cag ctg gat gta att     3235
 Arg Met Thr Thr Ser Pro Pro Lys Asp Ser Asp Gln Leu Asp Val Ile
         790                 795                 800

 cag gag aac cgg cag ctg ctg cag tta ctg acc aca tac att gtt cgg     3283
 Gln Glu Asn Arg Gln Leu Leu Gln Leu Leu Thr Thr Tyr Ile Val Arg
     805                 810                 815

 gaa aac agc caa gtt ggg gaa ggt gtg tgt gct gtt ctt ctg ggc acc     3331
 Glu Asn Ser Gln Val Gly Glu Gly Val Cys Ala Val Leu Leu Gly Thr
 820                 825                 830                 835

 ctg act ccc atg gca aca gag atg ctg gcc aac ggt gat ggg act ggc     3379
 Leu Thr Pro Met Ala Thr Glu Met Leu Ala Asn Gly Asp Gly Thr Gly
                 840                 845                 850

 ttc cct gaa ctt atg gtt gtg atg gcc act ctg gcc agt gca ggt caa     3427
 Phe Pro Glu Leu Met Val Val Met Ala Thr Leu Ala Ser Ala Gly Gln
             855                 860                 865

 ggt gct ggt cac ctt cag ctt cat aat gct gct gtg gat tgg ctg agc     3475
 Gly Ala Gly His Leu Gln Leu His Asn Ala Ala Val Asp Trp Leu Ser
         870                 875                 880

 aga tgc aag aaa tac ctg tca cag aag aat gta gtt gaa aaa ctg aat     3523
 Arg Cys Lys Lys Tyr Leu Ser Gln Lys Asn Val Val Glu Lys Leu Asn
     885                 890                 895

 gcc aat gta atg cat gga aag cat gtg atg atc ttg gag tgc aca tgc     3571
 Ala Asn Val Met His Gly Lys His Val Met Ile Leu Glu Cys Thr Cys
 900                 905                 910                 915

 cat atc atg tct tac ttg gct gat gtc acg aat gcc ctg agc cag agt     3619
 His Ile Met Ser Tyr Leu Ala Asp Val Thr Asn Ala Leu Ser Gln Ser
                 920                 925                 930

 aat ggt caa ggc cca agt cat ctc tca gtg gat ggg gaa gag cgg gcc     3667
 Asn Gly Gln Gly Pro Ser His Leu Ser Val Asp Gly Glu Glu Arg Ala
             935                 940                 945

 att gaa gta gac tca gac tgg gtg gag gag ttg gcg gtg gaa gag gaa     3715
 Ile Glu Val Asp Ser Asp Trp Val Glu Glu Leu Ala Val Glu Glu Glu
         950                 955                 960

 gat tcc cag gct gag gat tca gat gaa gat tct ctt tgc aat aaa ctc     3763
 Asp Ser Gln Ala Glu Asp Ser Asp Glu Asp Ser Leu Cys Asn Lys Leu
     965                 970                 975

 tgc act ttt acg atc aca cag aaa gaa ttc atg aac cag cat tgg tac     3811
 Cys Thr Phe Thr Ile Thr Gln Lys Glu Phe Met Asn Gln His Trp Tyr
 980                 985                 990                 995

 cac tgt cac acc tgt aaa atg gtg gat ggc gtg ggt gtc tgc aca gtg     3859
 His Cys His Thr Cys Lys Met Val Asp Gly Val Gly Val Cys Thr Val
                1000                1005                1010

 tgt gct aag gtg tgc cac aag gat cat gag att tcc tat gcc aag tat     3907
 Cys Ala Lys Val Cys His Lys Asp His Glu Ile Ser Tyr Ala Lys Tyr
            1015                1020                1025

 gga tcc ttc ttc tgt gac tgt gga gcc aag gaa gat ggc agc tgt ttg     3955
 Gly Ser Phe Phe Cys Asp Cys Gly Ala Lys Glu Asp Gly Ser Cys Leu
        1030                1035                1040

 gct ctg gtg aag aga act cct agc agt ggc atg agc tct acc atg aag     4003
 Ala Leu Val Lys Arg Thr Pro Ser Ser Gly Met Ser Ser Thr Met Lys
    1045                1050                1055

 gag tcg gca ttt cag agt gaa ccc agg att tca gag agt cta gtg cgt     4051
 Glu Ser Ala Phe Gln Ser Glu Pro Arg Ile Ser Glu Ser Leu Val Arg
1060                1065                1070                1075

 cat gcc agc acc tcc tcg cca gct gac aaa gcc aag gtt acc atc agt     4099
 His Ala Ser Thr Ser Ser Pro Ala Asp Lys Ala Lys Val Thr Ile Ser
                1080                1085                1090

 gat gga aag gtt gct gac gaa gag aag ccc aag aag agc agc ctc tgc     4147
 Asp Gly Lys Val Ala Asp Glu Glu Lys Pro Lys Lys Ser Ser Leu Cys
            1095                1100                1105

 cgc aca gta gag ggc tgc cgg gag gaa tta cag aac cag gcc aat ttc     4195
 Arg Thr Val Glu Gly Cys Arg Glu Glu Leu Gln Asn Gln Ala Asn Phe
        1110                1115                1120

 tcc ttc gct cct ctc gtg tta gac atg ctt aat ttc ctt atg gat gcc     4243
 Ser Phe Ala Pro Leu Val Leu Asp Met Leu Asn Phe Leu Met Asp Ala
    1125                1130                1135

 att cag acc aac ttc cag caa gct tca gcc gtc ggg agc agc agc cgt     4291
 Ile Gln Thr Asn Phe Gln Gln Ala Ser Ala Val Gly Ser Ser Ser Arg
1140                1145                1150                1155

 gct cag caa gcc ctc agt gag cta cac act gtg gag aag gca gtg gag     4339
 Ala Gln Gln Ala Leu Ser Glu Leu His Thr Val Glu Lys Ala Val Glu
                1160                1165                1170

 atg aca gac cag ctg atg gtt ccc acc tta ggg tcc cag gaa ggt gcc     4387
 Met Thr Asp Gln Leu Met Val Pro Thr Leu Gly Ser Gln Glu Gly Ala
            1175                1180                1185

 ttt gag aat gtg cgg atg aat tac agt gga gac cag ggc cag acc atc     4435
 Phe Glu Asn Val Arg Met Asn Tyr Ser Gly Asp Gln Gly Gln Thr Ile
        1190                1195                1200

 cgg cag ctg atc agt gct cat gtg ctc agg cgg gtg gct atg tgt gtg     4483
 Arg Gln Leu Ile Ser Ala His Val Leu Arg Arg Val Ala Met Cys Val
    1205                1210                1215

 ctc tcc tct ccc cat ggg cgc cgc caa cat ttg gct gtc agc cat gag     4531
 Leu Ser Ser Pro His Gly Arg Arg Gln His Leu Ala Val Ser His Glu
1220                1225                1230                1235

 aag ggc aag atc acc gtt ctg cag ctc tct gca ctc ctg aag caa gca     4579
 Lys Gly Lys Ile Thr Val Leu Gln Leu Ser Ala Leu Leu Lys Gln Ala
                1240                1245                1250

 gat tcc agc aaa agg aag tta act ctg acc cgc ttg gct tct gcc cca     4627
 Asp Ser Ser Lys Arg Lys Leu Thr Leu Thr Arg Leu Ala Ser Ala Pro
            1255                1260                1265

 gtt cct ttt act gtg ttg agc ctc aca gga aat ccc tgc aag gaa gac     4675
 Val Pro Phe Thr Val Leu Ser Leu Thr Gly Asn Pro Cys Lys Glu Asp
        1270                1275                1280

 tac ttg gcg gtt tgt ggg cta aag gac tgt cat gtg ctc acc ttt agt     4723
 Tyr Leu Ala Val Cys Gly Leu Lys Asp Cys His Val Leu Thr Phe Ser
    1285                1290                1295

 agc tca ggc tct gtt tcg gat cac ttg gtt ttg cac cct cag ttg gca     4771
 Ser Ser Gly Ser Val Ser Asp His Leu Val Leu His Pro Gln Leu Ala
1300                1305                1310                1315

 acg ggg aac ttc atc atc aaa gcc gtg tgg tta cct ggt tca cag acc     4819
 Thr Gly Asn Phe Ile Ile Lys Ala Val Trp Leu Pro Gly Ser Gln Thr
                1320                1325                1330

 gag tta gca att gtc acc gca gac ttt gtt aag att tat gac ctg tgt     4867
 Glu Leu Ala Ile Val Thr Ala Asp Phe Val Lys Ile Tyr Asp Leu Cys
            1335                1340                1345

 gtt gat gcc ttg agt cca acc ttc tat ttt ctc ctg cca agc tca aag     4915
 Val Asp Ala Leu Ser Pro Thr Phe Tyr Phe Leu Leu Pro Ser Ser Lys
        1350                1355                1360

 ata aga gat gtt acc ttc ctt ttc aat gag gag gga aag aac atc att     4963
 Ile Arg Asp Val Thr Phe Leu Phe Asn Glu Glu Gly Lys Asn Ile Ile
    1365                1370                1375

 gtt ata atg tct tcg gct ggg tac atc tat act cag ctt atg gaa gag     5011
 Val Ile Met Ser Ser Ala Gly Tyr Ile Tyr Thr Gln Leu Met Glu Glu
1380                1385                1390                1395

 gcc agc agt gcc cag cag gga ccc ttc tat gtc act aat gtg ttg gaa     5059
 Ala Ser Ser Ala Gln Gln Gly Pro Phe Tyr Val Thr Asn Val Leu Glu
                1400                1405                1410

 atc aat cat gag gac ctg aag gac agt aac agc cag gtg gcg ggc ggt     5107
 Ile Asn His Glu Asp Leu Lys Asp Ser Asn Ser Gln Val Ala Gly Gly
            1415                1420                1425

 ggt gtg tcc gtg tac tac tcc cac gtg ttg cag atg ttg ttc ttc agc     5155
 Gly Val Ser Val Tyr Tyr Ser His Val Leu Gln Met Leu Phe Phe Ser
        1430                1435                1440

 tat tgt caa ggc aaa tca ttc gca gcc acc atc agc agg aca acc ctg     5203
 Tyr Cys Gln Gly Lys Ser Phe Ala Ala Thr Ile Ser Arg Thr Thr Leu
    1445                1450                1455

 gag gtg ttg caa ctc ttc ccc atc aac atc aaa agt tcc aat ggt ggc     5251
 Glu Val Leu Gln Leu Phe Pro Ile Asn Ile Lys Ser Ser Asn Gly Gly
1460                1465                1470                1475

 agt aag act tct cct gct ctt tgc cag tgg tct gag gtg atg aac cac     5299
 Ser Lys Thr Ser Pro Ala Leu Cys Gln Trp Ser Glu Val Met Asn His
                1480                1485                1490

 cct ggc ttg gtg tgc tgt gtc cag caa act aca ggg gtg ccg ctg gta     5347
 Pro Gly Leu Val Cys Cys Val Gln Gln Thr Thr Gly Val Pro Leu Val
            1495                1500                1505

 gtt atg gtg aaa cca gac act ttt ctt atc cag gag att aag act ctt     5395
 Val Met Val Lys Pro Asp Thr Phe Leu Ile Gln Glu Ile Lys Thr Leu
        1510                1515                1520

 cct gct aaa gcg aag atc caa gac atg gtt gct att agg cac acg gcc     5443
 Pro Ala Lys Ala Lys Ile Gln Asp Met Val Ala Ile Arg His Thr Ala
    1525                1530                1535

 tgc aat gag cag cag cgg aca aca atg att ctg ctg tgc gag gat ggc     5491
 Cys Asn Glu Gln Gln Arg Thr Thr Met Ile Leu Leu Cys Glu Asp Gly
1540                1545                1550                1555

 agc ctg cgc att tac atg gcc aac gtg gag aac acc tcc tac tgg ctg     5539
 Ser Leu Arg Ile Tyr Met Ala Asn Val Glu Asn Thr Ser Tyr Trp Leu
                1560                1565                1570

 cag cca tcc ctg cag ccc agc agt gtc atc agc atc atg aag cct gtt     5587
 Gln Pro Ser Leu Gln Pro Ser Ser Val Ile Ser Ile Met Lys Pro Val
            1575                1580                1585

 cga aag cgc aaa aca gct aca atc agt aag gct cct tct cag atg act     5635
 Arg Lys Arg Lys Thr Ala Thr Ile Ser Lys Ala Pro Ser Gln Met Thr
        1590                1595                1600

 tca acc cgc acg tct agc cag gtg act ttc ccc att gac ttt ttt gaa     5683
 Ser Thr Arg Thr Ser Ser Gln Val Thr Phe Pro Ile Asp Phe Phe Glu
    1605                1610                1615

 cac aac cag cag ctg aca gat gtg gag ttt ggt ggt aac gac ctc cta     5731
 His Asn Gln Gln Leu Thr Asp Val Glu Phe Gly Gly Asn Asp Leu Leu
1620                1625                1630                1635

 cag gtc tat aat gca caa cag ata aaa cac cgg ctg aat tcc act ggc     5779
 Gln Val Tyr Asn Ala Gln Gln Ile Lys His Arg Leu Asn Ser Thr Gly
                1640                1645                1650

 atg tat gtg gcc aac acc aag ccc gga ggc ttc acc att gag att agt     5827
 Met Tyr Val Ala Asn Thr Lys Pro Gly Gly Phe Thr Ile Glu Ile Ser
            1655                1660                1665

 aac aac aat agc act atg gtg atg aca ggc atg cgg atc cag att ggg     5875
 Asn Asn Asn Ser Thr Met Val Met Thr Gly Met Arg Ile Gln Ile Gly
        1670                1675                1680

 act caa gca ata gaa cgg gcc ccg tca tat atc gag atc ttc ggc aga     5923
 Thr Gln Ala Ile Glu Arg Ala Pro Ser Tyr Ile Glu Ile Phe Gly Arg
    1685                1690                1695

 act atg cag ctc aac ctg agt cgc tca cgc tgg ttt gac ttc ccc ttc     5971
 Thr Met Gln Leu Asn Leu Ser Arg Ser Arg Trp Phe Asp Phe Pro Phe
1700                1705                1710                1715

 acc aga gaa gaa gcc ctg cag gct gat aag aag ctg aac ctc ttc agt     6019
 Thr Arg Glu Glu Ala Leu Gln Ala Asp Lys Lys Leu Asn Leu Phe Ser
                1720                1725                1730

 gag tca cca acc cct ggt gca gac tct gtc ctc att gtg act gcg aaa     6067
 Glu Ser Pro Thr Pro Gly Ala Asp Ser Val Leu Ile Val Thr Ala Lys
            1735                1740                1745

 ttg gga gcc act ggc ctg tgg ctg tcc aac att ctg gga tct ctc cac     6115
 Leu Gly Ala Thr Gly Leu Trp Leu Ser Asn Ile Leu Gly Ser Leu His
        1750                1755                1760

 tct gct gat ttt tct gtc ctt tca tca gga aac ttt gag ctt cat ttg     6163
 Ser Ala Asp Phe Ser Val Leu Ser Ser Gly Asn Phe Glu Leu His Leu
    1765                1770                1775

 atg tat taa agaggca aggtgacagg aaaggagtac accggagcat ggtagcagta     6219
 Met Tyr 
1780

 aagatagggc tgcactgtgt tgagtattca tttcaatagt gttgtgtcca cctcactaat   6279

 ggggctactt ctgtgtttag gccgagagga ggcagattga catgaaattg caaggctttc   6339

 ttaacgcaca gaggaagacc tcaggtcaca catggctgag agatggttgg caatggcttg   6399

 ctatgccact gaaaactaaa ctctcagaat acaaatcctt gagccttact caagactgca   6459

 tttctctgtc atttattggc cactgtctga tattctttct tctagatata gttgctgtta   6519

 gtgtgaatga tcatgatctg tactttgaac aaagaaagtg tgtagagacc cctgggagtg   6579

 aggggtaggg gatacaatac tctgaagcag aagaggaccc ttgcagtgat ggttagggac   6639

 tcttctgagt aggagacgta atcggctttt ggtccatgga acttttacca catgtattca   6699

 gcatatatac acgattaaag tgctgcaaat atctcag                            6736




      <210> 207
      <211> 8037
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1654)..(7329)

      <400> 207
 atgggcttcc tgcaccagct gcagctgctg ctctggaaga acgtgacgct caaacgccgg     60

 agcccgtggg tcctggcctt cgagatcttc atccccctgg tgctgttctt tatcctgctg    120

 gggctgcgac agaagaagcc caccatctcc gtgaaggaag tccccttcta cacagcggcg    180

 cccctgacgt ctgccggcat cctgcctgtc atgcaatcgc tgtgcccgga cggccagcga    240

 gacgagttcg gcttcctgca gtacgccaac tccacggtca cgcagctgct tgagcgcctg    300

 gaccgcgtgg tggaggaagg caacctgttt gacccagcgc ggcccagcct gggctcagag    360

 ctcgaggccc tacgccagca tctggaggcc ctcagtgcgg gcccgggcac ctcggggagc    420

 cacctggaca gatccacagt gtcttccttc tctctggact cggtggccag aaacccgcag    480

 gagctctggc gtttcctgac gcaaaacttg tcgctgccca atagcacggc ccaagcactc    540

 ttggccgccc gtgtggaccc gcccgaggtc taccacctgc tctttggtcc ctcatctgcc    600

 ctggattcac agtctggcct ccacaagggt caggagccct ggagccgcct agggggcaat    660

 cccctgttcc ggatggagga gctgctgctg gctcctgccc tcctggagca gctcacctgc    720

 acgccgggct cgggggagct gggccggatc ctcactgtgc ctgagagtca gaagggagcc    780

 ctgcagggct accgggatgc tgtctgcagt gggcaggctg ctgcgcgtgc caggcgcttc    840

 tctgggctgt ctgctgagct ccggaaccag ctggacgtgg ccaaggtctc ccagcagctg    900

 ggcctggatg cccccaacgg ctcggactcc tcgccacagg cgccaccccc acggaggctg    960

 caggcgcttc tgggggacct gctggatgcc cagaaggttc tgcaggatgt ggatgtcctg   1020

 tcggccctgg ccctgctact gccccagggt gcctgcactg gccggacccc cggaccccca   1080

 gccagtggtg cgggtggggc ggccaatggc actggggcag gggcagtcat gggccccaac   1140

 gccaccgctg aggagggcgc accctctgct gcagcactgg ccaccccgga cacgctgcag   1200

 ggccagtgct cagccttcgt acagctctgg gccggcctgc agcccatctt gtgtggcaac   1260

 aaccgcacca ttgaacccga ggcgctgcgg cggggcaaca tgagctcctt gggcttcacg   1320

 agcaagaagc agcggaacct gggcctcctc gtgcacctca tgaccagcaa ccccaaaatc   1380

 ctgtacgcgc ctgcgggctc tgaggtcgac cgcgtcatcc tcaaggccaa cgagactttt   1440

 gcttttgtgg gcaacgtgac tcactatgcc caggtctggc tcaacatctc ggcggagatc   1500

 cgcagcttcc tggagcaggg caggctgcag caacacctgc gctggctgca gcagtatgta   1560

 gcagagctgc ggctgcaccc cgaggcactg aacctgtcac tggatgagct gccgccggcc   1620

 ctgagacagg acaacttctc gctgcccagt ggc atg gcc ctc ctg cag cag ctg    1674
                                      Met Ala Leu Leu Gln Gln Leu
                                        1               5

 gat acc att gac aac gcg gcc tgc ggc tgg atc cag ttc atg tcc aag     1722
 Asp Thr Ile Asp Asn Ala Ala Cys Gly Trp Ile Gln Phe Met Ser Lys
          10                  15                  20

 gtg agc gtg gac atc ttc aag ggc ttc ccc gac gag gag agc att gtc     1770
 Val Ser Val Asp Ile Phe Lys Gly Phe Pro Asp Glu Glu Ser Ile Val
      25                  30                  35

 aac tac acc ctc aac cag gcc tac cag gac aac gtc act gtt ttt gcc     1818
 Asn Tyr Thr Leu Asn Gln Ala Tyr Gln Asp Asn Val Thr Val Phe Ala
  40                  45                  50                  55

 agt gtg atc ttc cag acc cgg aag gac ggc tcg ctc ccg cct cac gtg     1866
 Ser Val Ile Phe Gln Thr Arg Lys Asp Gly Ser Leu Pro Pro His Val
                  60                  65                  70

 cac tac aag atc cgc cag aac tcc agc ttc acc gag aaa acc aac gag     1914
 His Tyr Lys Ile Arg Gln Asn Ser Ser Phe Thr Glu Lys Thr Asn Glu
              75                  80                  85

 atc cgc cgc gcc tac tgg cgg cct ggg ccc aat act ggc ggc cgc ttc     1962
 Ile Arg Arg Ala Tyr Trp Arg Pro Gly Pro Asn Thr Gly Gly Arg Phe
          90                  95                 100

 tac ttc ctc tac ggc ttc gtc tgg atc cag gac atg atg gag cgc gcc     2010
 Tyr Phe Leu Tyr Gly Phe Val Trp Ile Gln Asp Met Met Glu Arg Ala
     105                 110                 115

 atc atc gac act ttt gtg ggg cac gac gtg gtg gag cca ggc agc tac     2058
 Ile Ile Asp Thr Phe Val Gly His Asp Val Val Glu Pro Gly Ser Tyr
 120                 125                 130                 135

 gtg cag atg ttc ccc tac ccc tgc tac aca cgc gat gac ttc ctg ttt     2106
 Val Gln Met Phe Pro Tyr Pro Cys Tyr Thr Arg Asp Asp Phe Leu Phe
                 140                 145                 150

 gtc att gag cac atg atg ccg ctg tgc atg gtg atc tcc tgg gtc tac     2154
 Val Ile Glu His Met Met Pro Leu Cys Met Val Ile Ser Trp Val Tyr
             155                 160                 165

 tcc gtg gcc atg acc atc cag cac atc gtg gcg gag aag gag cac cgg     2202
 Ser Val Ala Met Thr Ile Gln His Ile Val Ala Glu Lys Glu His Arg
         170                 175                 180

 ctc aag gag gtg atg aag acc atg ggc ctg aac aac gcg gtg cac tgg     2250
 Leu Lys Glu Val Met Lys Thr Met Gly Leu Asn Asn Ala Val His Trp
     185                 190                 195

 gtg gcc tgg ttc atc acc ggc ttt gtg cag ctg tcc atc tcc gtg aca     2298
 Val Ala Trp Phe Ile Thr Gly Phe Val Gln Leu Ser Ile Ser Val Thr
 200                 205                 210                 215

 gca ctc acc gcc atc ctg aag tac ggc cag gtg ctt atg cac agc cac     2346
 Ala Leu Thr Ala Ile Leu Lys Tyr Gly Gln Val Leu Met His Ser His
                 220                 225                 230

 gtg gtc atc atc tgg ctc ttc ctg gca gtc tac gcg gtg gcc acc atc     2394
 Val Val Ile Ile Trp Leu Phe Leu Ala Val Tyr Ala Val Ala Thr Ile
             235                 240                 245

 atg ttc tgc ttc ctg gtg tct gtg ctg tac tcc aag gcc aag ctg gcc     2442
 Met Phe Cys Phe Leu Val Ser Val Leu Tyr Ser Lys Ala Lys Leu Ala
         250                 255                 260

 tcg gcc tgc ggt ggc atc atc tac ttc ctg agc tac gtg ccc tac atg     2490
 Ser Ala Cys Gly Gly Ile Ile Tyr Phe Leu Ser Tyr Val Pro Tyr Met
     265                 270                 275

 tac gtg gcg atc cga gag gag gtg gcg cat gat aag atc acg gcc ttc     2538
 Tyr Val Ala Ile Arg Glu Glu Val Ala His Asp Lys Ile Thr Ala Phe
 280                 285                 290                 295

 gag aag tgc atc gcg tcc ctc atg tcc acg acg gcc ttt ggt ctg ggc     2586
 Glu Lys Cys Ile Ala Ser Leu Met Ser Thr Thr Ala Phe Gly Leu Gly
                 300                 305                 310

 tct aag tac ttc gcg ctg tat gag gtg gcc ggc gtg ggc atc cag tgg     2634
 Ser Lys Tyr Phe Ala Leu Tyr Glu Val Ala Gly Val Gly Ile Gln Trp
             315                 320                 325

 cac acc ttc agc cag tcc ccg gtg gag ggg gac gac ttc aac ttg ctc     2682
 His Thr Phe Ser Gln Ser Pro Val Glu Gly Asp Asp Phe Asn Leu Leu
         330                 335                 340

 ctg gct gtc acc atg ctg atg gtg gac gcc gtg gtc tat ggc atc ctc     2730
 Leu Ala Val Thr Met Leu Met Val Asp Ala Val Val Tyr Gly Ile Leu
     345                 350                 355

 acg tgg tac att gag gct gtg cac cca ggc atg tac ggg ctg ccc cgg     2778
 Thr Trp Tyr Ile Glu Ala Val His Pro Gly Met Tyr Gly Leu Pro Arg
 360                 365                 370                 375

 ccc tgg tac ttc cca ctg cag aag tcc tac tgg ctg ggc agt ggg cgg     2826
 Pro Trp Tyr Phe Pro Leu Gln Lys Ser Tyr Trp Leu Gly Ser Gly Arg
                 380                 385                 390

 aca gaa gcc tgg gag tgg agc tgg ccg tgg gca cgc acc ccc cgc ctc     2874
 Thr Glu Ala Trp Glu Trp Ser Trp Pro Trp Ala Arg Thr Pro Arg Leu
             395                 400                 405

 agt gtc atg gag gag gac cag gcc tgt gcc atg gag agc cgg cgc ttt     2922
 Ser Val Met Glu Glu Asp Gln Ala Cys Ala Met Glu Ser Arg Arg Phe
         410                 415                 420

 gag gag acc cgt ggc atg gag gag gag ccc acc cac ctg cct ctg gtt     2970
 Glu Glu Thr Arg Gly Met Glu Glu Glu Pro Thr His Leu Pro Leu Val
     425                 430                 435

 gtc tgc gtg gac aaa ctc acc aag gtc tac aag gac gac aag aag ctg     3018
 Val Cys Val Asp Lys Leu Thr Lys Val Tyr Lys Asp Asp Lys Lys Leu
 440                 445                 450                 455

 gcc ctg aac aag ctg agc ctg aac ctc tac gag aac cag gtg gtc tcc     3066
 Ala Leu Asn Lys Leu Ser Leu Asn Leu Tyr Glu Asn Gln Val Val Ser
                 460                 465                 470

 ttc ttg ggc cac aac ggg gcg ggc aag acc acc acc atg tcc atc ctg     3114
 Phe Leu Gly His Asn Gly Ala Gly Lys Thr Thr Thr Met Ser Ile Leu
             475                 480                 485

 acc ggc ctg ttc cct cca acg tcg ggt tcc gcc acc atc tac ggg cac     3162
 Thr Gly Leu Phe Pro Pro Thr Ser Gly Ser Ala Thr Ile Tyr Gly His
         490                 495                 500

 gac atc cgc acg gag atg gat gag atc cgc aag aac ctg ggc atg tgc     3210
 Asp Ile Arg Thr Glu Met Asp Glu Ile Arg Lys Asn Leu Gly Met Cys
     505                 510                 515

 ccg cag cac aat gtg ctc ttt gac cgg ctc acg gtg gag gaa cac ctc     3258
 Pro Gln His Asn Val Leu Phe Asp Arg Leu Thr Val Glu Glu His Leu
 520                 525                 530                 535

 tgg ttc tac tca cgg ctc aag agc atg gct cag gag gag atc cgc aga     3306
 Trp Phe Tyr Ser Arg Leu Lys Ser Met Ala Gln Glu Glu Ile Arg Arg
                 540                 545                 550

 gag atg gac aag atg atc gag gac ctg gag ctc tcc aac aaa cgg cac     3354
 Glu Met Asp Lys Met Ile Glu Asp Leu Glu Leu Ser Asn Lys Arg His
             555                 560                 565

 tca ctg gtg cag aca ttg tcg ggt ggc atg aag cgc aag ctg tcc gtg     3402
 Ser Leu Val Gln Thr Leu Ser Gly Gly Met Lys Arg Lys Leu Ser Val
         570                 575                 580

 gcc atc gcc ttc gtg ggc ggc tct cgc gcc atc atc ctg gac gag ccc     3450
 Ala Ile Ala Phe Val Gly Gly Ser Arg Ala Ile Ile Leu Asp Glu Pro
     585                 590                 595

 acg gcg ggc gtg gac ccc tac gcg cgc cgc gcc atc tgg gac ctc atc     3498
 Thr Ala Gly Val Asp Pro Tyr Ala Arg Arg Ala Ile Trp Asp Leu Ile
 600                 605                 610                 615

 ctg aag tac aag cca ggc cgc acc atc ctt ctg tcc acc cac cac atg     3546
 Leu Lys Tyr Lys Pro Gly Arg Thr Ile Leu Leu Ser Thr His His Met
                 620                 625                 630

 gat gag gct gac ctg ctt ggg gac cgc att gcc atc atc tcc cat ggg     3594
 Asp Glu Ala Asp Leu Leu Gly Asp Arg Ile Ala Ile Ile Ser His Gly
             635                 640                 645

 aag ctc aag tgc tgc ggc tcc ccg ctc ttc ctc aag ggc acc tat ggc     3642
 Lys Leu Lys Cys Cys Gly Ser Pro Leu Phe Leu Lys Gly Thr Tyr Gly
         650                 655                 660

 gac ggg tac cgc ctc acg ctg gtc aag cgg ccc gcc gag ccg ggg ggc     3690
 Asp Gly Tyr Arg Leu Thr Leu Val Lys Arg Pro Ala Glu Pro Gly Gly
     665                 670                 675

 ccc caa gag cca ggg ctg gca tcc agc ccc cca ggt cgg gcc ccg ctg     3738
 Pro Gln Glu Pro Gly Leu Ala Ser Ser Pro Pro Gly Arg Ala Pro Leu
 680                 685                 690                 695

 agc agc tgc tcc gag ctc cag gtg tcc cag ttc atc cgc aag cat gtg     3786
 Ser Ser Cys Ser Glu Leu Gln Val Ser Gln Phe Ile Arg Lys His Val
                 700                 705                 710

 gcc tcc tgc ctg ctg gtc tca gac aca agc acg gag ctc tcc tac atc     3834
 Ala Ser Cys Leu Leu Val Ser Asp Thr Ser Thr Glu Leu Ser Tyr Ile
             715                 720                 725

 ctg ccc agc gag gcc gcc aag aag ggg gct ttc gag cgc ctc ttc cag     3882
 Leu Pro Ser Glu Ala Ala Lys Lys Gly Ala Phe Glu Arg Leu Phe Gln
         730                 735                 740

 cac ctg gag cgc agc ctg gat gca ctg cac ctc agc agc ttc ggg ctg     3930
 His Leu Glu Arg Ser Leu Asp Ala Leu His Leu Ser Ser Phe Gly Leu
     745                 750                 755

 atg gac acg acc ctg gag gaa gtg ttc ctc aag gtg tcg gag gag gat     3978
 Met Asp Thr Thr Leu Glu Glu Val Phe Leu Lys Val Ser Glu Glu Asp
 760                 765                 770                 775

 cag tcg ctg gag aac agt gag gcc gat gtg aag gag tcc agg aag gat     4026
 Gln Ser Leu Glu Asn Ser Glu Ala Asp Val Lys Glu Ser Arg Lys Asp
                 780                 785                 790

 gtg ctc cct ggg gcg gag ggc ccg gcg tct ggg gag ggt cac gct ggc     4074
 Val Leu Pro Gly Ala Glu Gly Pro Ala Ser Gly Glu Gly His Ala Gly
             795                 800                 805

 aat ctg gcc cgg tgc tcg gag ctg acc cag tcg cag gca tcg ctg cag     4122
 Asn Leu Ala Arg Cys Ser Glu Leu Thr Gln Ser Gln Ala Ser Leu Gln
         810                 815                 820

 tcg gcg tca tct gtg ggc tct gcc cgt ggc gac gag gga gct ggc tac     4170
 Ser Ala Ser Ser Val Gly Ser Ala Arg Gly Asp Glu Gly Ala Gly Tyr
     825                 830                 835

 acc gac gtc tat ggc gac tac cgc ccc ctc ttt gat aac cca cag gac     4218
 Thr Asp Val Tyr Gly Asp Tyr Arg Pro Leu Phe Asp Asn Pro Gln Asp
 840                 845                 850                 855

 cca gac aat gtc agc ctg caa gag gtg gag gca gag gcc ctg tcg agg     4266
 Pro Asp Asn Val Ser Leu Gln Glu Val Glu Ala Glu Ala Leu Ser Arg
                 860                 865                 870

 gtc ggc cag ggc agc cgc aag ctg gac ggc ggg tgg ctg aag gtg cgc     4314
 Val Gly Gln Gly Ser Arg Lys Leu Asp Gly Gly Trp Leu Lys Val Arg
             875                 880                 885

 cag ttc cac ggg ctg ctg gtc aaa cgc ttc cac tgc gcc cgc cgc aac     4362
 Gln Phe His Gly Leu Leu Val Lys Arg Phe His Cys Ala Arg Arg Asn
         890                 895                 900

 tcc aag gca ctc ttc tcc cag atc ttg ctg cca gcc ttc ttc gtc tgc     4410
 Ser Lys Ala Leu Phe Ser Gln Ile Leu Leu Pro Ala Phe Phe Val Cys
     905                 910                 915

 gtg gcc atg acc gtg gcc ctg tcc gtc ccg gag att ggt gat ctg ccc     4458
 Val Ala Met Thr Val Ala Leu Ser Val Pro Glu Ile Gly Asp Leu Pro
 920                 925                 930                 935

 ccg ctg gtc ctg tca cct tcc cag tac cac aac tac acc cag ccc cgt     4506
 Pro Leu Val Leu Ser Pro Ser Gln Tyr His Asn Tyr Thr Gln Pro Arg
                 940                 945                 950

 ggc aat ttc atc ccc tac gcc aac gag gag cgc cgc gag tac cgg ctg     4554
 Gly Asn Phe Ile Pro Tyr Ala Asn Glu Glu Arg Arg Glu Tyr Arg Leu
             955                 960                 965

 cgg cta tcg ccc gac gcc agc ccc cag cag ctc gtg agc acg ttc cgg     4602
 Arg Leu Ser Pro Asp Ala Ser Pro Gln Gln Leu Val Ser Thr Phe Arg
         970                 975                 980

 ctg ccg tcg ggg gtg ggt gcc acc tgc gtg ctc aag tct ccc gcc aac     4650
 Leu Pro Ser Gly Val Gly Ala Thr Cys Val Leu Lys Ser Pro Ala Asn
     985                 990                 995

 ggc tcg ctg ggg ccc acg ttg aac ctg agc agc ggg gag tcg cgc ctg     4698
 Gly Ser Leu Gly Pro Thr Leu Asn Leu Ser Ser Gly Glu Ser Arg Leu
1000                1005                1010                1015

 ctg gcg gct cgg ttc ttc gac agc atg tgt ctg gag tcc ttc aca cag     4746
 Leu Ala Ala Arg Phe Phe Asp Ser Met Cys Leu Glu Ser Phe Thr Gln
                1020                1025                1030

 ggg ctg cca ctg tcc aat ttc gtg cca ccc cca ccc tcg ccc gcc cca     4794
 Gly Leu Pro Leu Ser Asn Phe Val Pro Pro Pro Pro Ser Pro Ala Pro
            1035                1040                1045

 tct gac tcg cca gcg tcc ccg gat gag gac ctg cag gcc tgg aac gtc     4842
 Ser Asp Ser Pro Ala Ser Pro Asp Glu Asp Leu Gln Ala Trp Asn Val
        1050                1055                1060

 tcc ctg ccg ccc acc gct ggg cca gaa atg tgg acg tcg gca ccc tcc     4890
 Ser Leu Pro Pro Thr Ala Gly Pro Glu Met Trp Thr Ser Ala Pro Ser
    1065                1070                1075

 ctg ccg cgc ctg gta cgg gag ccc gtc cgc tgc acc tgc tct gcg cag     4938
 Leu Pro Arg Leu Val Arg Glu Pro Val Arg Cys Thr Cys Ser Ala Gln
1080                1085                1090                1095

 ggc acc ggc ttc tcc tgc ccc agc agt gtg ggc ggg cac ccg ccc cag     4986
 Gly Thr Gly Phe Ser Cys Pro Ser Ser Val Gly Gly His Pro Pro Gln
                1100                1105                1110

 atg cgg gtg gtc aca ggc gac atc ctg acc gac atc acc ggc cac aat     5034
 Met Arg Val Val Thr Gly Asp Ile Leu Thr Asp Ile Thr Gly His Asn
            1115                1120                1125

 gtc tct gag tac ctg ctc ttc acc tcc gac cgc ttc cga ctg cac cgg     5082
 Val Ser Glu Tyr Leu Leu Phe Thr Ser Asp Arg Phe Arg Leu His Arg
        1130                1135                1140

 tat ggg gcc atc acc ttt gga aac gtc ctg aag tcc atc cca gcc tca     5130
 Tyr Gly Ala Ile Thr Phe Gly Asn Val Leu Lys Ser Ile Pro Ala Ser
    1145                1150                1155

 ttt ggc acc agg gcc cca ccc atg gtg cgg aag atc gcg gtg cgc agg     5178
 Phe Gly Thr Arg Ala Pro Pro Met Val Arg Lys Ile Ala Val Arg Arg
1160                1165                1170                1175

 gct gcc cag gtt ttc tac aac aac aag ggc tat cac agc atg ccc acc     5226
 Ala Ala Gln Val Phe Tyr Asn Asn Lys Gly Tyr His Ser Met Pro Thr
                1180                1185                1190

 tac ctc aac agc ctc aac aac gcc atc ctg cgt gcc aac ctg ccc aag     5274
 Tyr Leu Asn Ser Leu Asn Asn Ala Ile Leu Arg Ala Asn Leu Pro Lys
            1195                1200                1205

 agc aag ggc aac ccg gcg gct tac ggc atc acc gtc acc aac cac ccc     5322
 Ser Lys Gly Asn Pro Ala Ala Tyr Gly Ile Thr Val Thr Asn His Pro
        1210                1215                1220

 atg aat aag acc agc gcc agc ctc tcc ctg gat tac ctg ctg cag ggc     5370
 Met Asn Lys Thr Ser Ala Ser Leu Ser Leu Asp Tyr Leu Leu Gln Gly
    1225                1230                1235

 acg gat gtc gtc atc gcc atc ttc atc atc gtg gcc atg tcc ttc gtg     5418
 Thr Asp Val Val Ile Ala Ile Phe Ile Ile Val Ala Met Ser Phe Val
1240                1245                1250                1255

 ccg gcc agc ttc gtt gtc ttc ctc gtg gcc gag aag tcc acc aag gcc     5466
 Pro Ala Ser Phe Val Val Phe Leu Val Ala Glu Lys Ser Thr Lys Ala
                1260                1265                1270

 aag cat ctg cag ttt gtc agc ggc tgc aac ccc atc atc tac tgg ctg     5514
 Lys His Leu Gln Phe Val Ser Gly Cys Asn Pro Ile Ile Tyr Trp Leu
            1275                1280                1285

 gcg aac tac gtg tgg gac atg ccg ccc cca ccc ctg cag ctc aac tac     5562
 Ala Asn Tyr Val Trp Asp Met Pro Pro Pro Pro Leu Gln Leu Asn Tyr
        1290                1295                1300

 ctg gtc ccc gct acc tgc tgt gtc atc atc ctg ttt gtg ttc gac ctg     5610
 Leu Val Pro Ala Thr Cys Cys Val Ile Ile Leu Phe Val Phe Asp Leu
    1305                1310                1315

 ccg gcc tac acg tcg ccc acc aac ttc cct gcc gtc ctc tcc ctc ttc     5658
 Pro Ala Tyr Thr Ser Pro Thr Asn Phe Pro Ala Val Leu Ser Leu Phe
1320                1325                1330                1335

 ctg ctc tat ggg tgg tcc atc acg ccc atc atg tac ccg gcc tcc ttc     5706
 Leu Leu Tyr Gly Trp Ser Ile Thr Pro Ile Met Tyr Pro Ala Ser Phe
                1340                1345                1350

 tgg ttc gag gtc ccc agc tcc gcc tac gtg ttc ctc att gtc atc aat     5754
 Trp Phe Glu Val Pro Ser Ser Ala Tyr Val Phe Leu Ile Val Ile Asn
            1355                1360                1365

 ctc ttc atc ggc atc acc gcc acc gtg gcc acc ttc ctg cta cag ctc     5802
 Leu Phe Ile Gly Ile Thr Ala Thr Val Ala Thr Phe Leu Leu Gln Leu
        1370                1375                1380

 ttc gag cac gac aag gac ctg aag gtt gtc aac agt tac ctg aaa agc     5850
 Phe Glu His Asp Lys Asp Leu Lys Val Val Asn Ser Tyr Leu Lys Ser
    1385                1390                1395

 tgc ttc ctc att ttc ccc aac tac aac ctg ggc cac ggg ctc atg gag     5898
 Cys Phe Leu Ile Phe Pro Asn Tyr Asn Leu Gly His Gly Leu Met Glu
1400                1405                1410                1415

 atg gcc tac aac gag tac atc aac gag tac tac gcc aag att ggc cag     5946
 Met Ala Tyr Asn Glu Tyr Ile Asn Glu Tyr Tyr Ala Lys Ile Gly Gln
                1420                1425                1430

 ttt gac aag atg aag tcc ccg ttc gag tgg gac att gtc acc cgc gga     5994
 Phe Asp Lys Met Lys Ser Pro Phe Glu Trp Asp Ile Val Thr Arg Gly
            1435                1440                1445

 ctg gtg gcc atg gcg gtt gag ggc gtc gtg ggt ttc ctc ctg acc atc     6042
 Leu Val Ala Met Ala Val Glu Gly Val Val Gly Phe Leu Leu Thr Ile
        1450                1455                1460

 atg tgc cag tac aac ttc ctg cgg cgg cca cag cgc atg cct gtg tct     6090
 Met Cys Gln Tyr Asn Phe Leu Arg Arg Pro Gln Arg Met Pro Val Ser
    1465                1470                1475

 acc aag cct gtg gag gat gat gtg gac gtg gcc agt gag cgg cag cga     6138
 Thr Lys Pro Val Glu Asp Asp Val Asp Val Ala Ser Glu Arg Gln Arg
1480                1485                1490                1495

 gtg ctc cgg gga gac gcc gac aat gac atg gtc aag att gag aac ctg     6186
 Val Leu Arg Gly Asp Ala Asp Asn Asp Met Val Lys Ile Glu Asn Leu
                1500                1505                1510

 acc aag gtc tac aag tcc cgg aag att ggc cgt atc ctg gcc gtt gac     6234
 Thr Lys Val Tyr Lys Ser Arg Lys Ile Gly Arg Ile Leu Ala Val Asp
            1515                1520                1525

 cgc ctg tgc ctg ggt gtg cgt cct ggc gag tgc ttc ggg ctc ctg ggc     6282
 Arg Leu Cys Leu Gly Val Arg Pro Gly Glu Cys Phe Gly Leu Leu Gly
        1530                1535                1540

 gtc aac ggt gcg ggc aag acc agc acc ttc aag atg ctg acc ggc gac     6330
 Val Asn Gly Ala Gly Lys Thr Ser Thr Phe Lys Met Leu Thr Gly Asp
    1545                1550                1555

 gag agc acg acg ggg ggc gag gcc ttc gtc aat gga cac agc gtg ctg     6378
 Glu Ser Thr Thr Gly Gly Glu Ala Phe Val Asn Gly His Ser Val Leu
1560                1565                1570                1575

 aag gag ctg ctc cag gtg cag cag agc ctc ggc tac tgc ccg cag tgt     6426
 Lys Glu Leu Leu Gln Val Gln Gln Ser Leu Gly Tyr Cys Pro Gln Cys
                1580                1585                1590

 gac gcg ctg ttc gac gag ctc acg gcc cgg gag cac ctg cag ctg tac     6474
 Asp Ala Leu Phe Asp Glu Leu Thr Ala Arg Glu His Leu Gln Leu Tyr
            1595                1600                1605

 acg cgg ctg cgt ggg atc tcc tgg aag gac gag gcc cgg gtg gtg aag     6522
 Thr Arg Leu Arg Gly Ile Ser Trp Lys Asp Glu Ala Arg Val Val Lys
        1610                1615                1620

 tgg gct ctg gag aag ctg gag ctg acc aag tac gca gac aag ccg gct     6570
 Trp Ala Leu Glu Lys Leu Glu Leu Thr Lys Tyr Ala Asp Lys Pro Ala
    1625                1630                1635

 ggc acc tac agc ggc ggc aac aag cgg aag ctc tcc acg gcc atc gcc     6618
 Gly Thr Tyr Ser Gly Gly Asn Lys Arg Lys Leu Ser Thr Ala Ile Ala
1640                1645                1650                1655

 ctc att ggg tac cca gcc ttc atc ttc ctg gac gag ccc acc aca ggc     6666
 Leu Ile Gly Tyr Pro Ala Phe Ile Phe Leu Asp Glu Pro Thr Thr Gly
                1660                1665                1670

 atg gac ccc aag gcc cgg cgc ttc ctc tgg aac ctc atc ctc gac ctc     6714
 Met Asp Pro Lys Ala Arg Arg Phe Leu Trp Asn Leu Ile Leu Asp Leu
            1675                1680                1685

 atc aag aca ggg cgt tca gtg gtg ctg aca tca cac agc atg gag gag     6762
 Ile Lys Thr Gly Arg Ser Val Val Leu Thr Ser His Ser Met Glu Glu
        1690                1695                1700

 tgc gag gcg ctg tgc acg cgg ctg gcc atc atg gtg aac ggt cgc ctg     6810
 Cys Glu Ala Leu Cys Thr Arg Leu Ala Ile Met Val Asn Gly Arg Leu
    1705                1710                1715

 cgg tgc ctg ggc agc atc cag cac ctg aag aac cgg ttt gga gat ggc     6858
 Arg Cys Leu Gly Ser Ile Gln His Leu Lys Asn Arg Phe Gly Asp Gly
1720                1725                1730                1735

 tac atg atc acg gtg cgg acc aag agc agc cag agt gtg aag gac gtg     6906
 Tyr Met Ile Thr Val Arg Thr Lys Ser Ser Gln Ser Val Lys Asp Val
                1740                1745                1750

 gtg cgg ttc ttc aac cgc aac ttc ccg gaa gcc atg ctc aag gag cgg     6954
 Val Arg Phe Phe Asn Arg Asn Phe Pro Glu Ala Met Leu Lys Glu Arg
            1755                1760                1765

 cac cac aca aag gtg cag tac cag ctc aag tcg gag cac atc tcg ctg     7002
 His His Thr Lys Val Gln Tyr Gln Leu Lys Ser Glu His Ile Ser Leu
        1770                1775                1780

 gcc cag gtg ttc agc aag atg gag cag gtg tct ggc gtg ctg ggc atc     7050
 Ala Gln Val Phe Ser Lys Met Glu Gln Val Ser Gly Val Leu Gly Ile
    1785                1790                1795

 gag gac tac tcg gtc agc cag acc aca ctg gac aat gtg ttc gtg aac     7098
 Glu Asp Tyr Ser Val Ser Gln Thr Thr Leu Asp Asn Val Phe Val Asn
1800                1805                1810                1815

 ttt gcc aag aag cag agt gac aac ctg gag cag cag gag acg gag ccg     7146
 Phe Ala Lys Lys Gln Ser Asp Asn Leu Glu Gln Gln Glu Thr Glu Pro
                1820                1825                1830

 cca tcc gca ctg cag tcc cct ctc ggc tgc ttg ctc agc ctg ctc cgg     7194
 Pro Ser Ala Leu Gln Ser Pro Leu Gly Cys Leu Leu Ser Leu Leu Arg
            1835                1840                1845

 ccc cgg tct gcc ccc acg gag ctc cgg gca ctt gtg gca gac gag ccc     7242
 Pro Arg Ser Ala Pro Thr Glu Leu Arg Ala Leu Val Ala Asp Glu Pro
        1850                1855                1860

 gag gac ctg gac acg gag gac gag ggc ctc atc agc ttc gag gag gag     7290
 Glu Asp Leu Asp Thr Glu Asp Glu Gly Leu Ile Ser Phe Glu Glu Glu
    1865                1870                1875

 cgg gcc cag ctg tcc ttc aac acg gac acg ctc tgc tga ccacccagag      7339
 Arg Ala Gln Leu Ser Phe Asn Thr Asp Thr Leu Cys 
1880                1885                1890

 ctgggccagg gaggacacgc tccactgacc acccagagct gggccaggga ctcaacaatg   7399

 gggacagaag tcccccagtg cctgccaggg cctggagtgg aggttcagga ccaaggggct   7459

 tctggtcctc cagcccctgt actcggccat gccctgcggt cactgcggtt gccgccccta   7519

 attgtgccaa aggctgaccc ggcccgggct gcgtacaccc ttgccctgct ttgccttaaa   7579

 gcctcggggt ctgcccggcc cctcgcccct gcctggcact gctcaccgcc caaggcgacg   7639

 ccggctggac caggcactgc tggcctttct cctgcccggc ctcggaacca gcttttctct   7699

 cttacgatga aggctgatgc cgagagcggg ctgtgggcgg agctgggtca gtcccgtatt   7759

 tattttgctt tgagaagagg ctcctctggc cctgctctcc tgcagggagg tggctgtccc   7819

 gcgggaagcc atcagcttgg gccagctggc aggtggcagg aatggagaag ctgaccctgc   7879

 tggccaggca aggggccaga ccccccccaa cccccagctg ccatcgctct cccacccagc   7939

 ttggccccct gcccgcccac ctccctggga gccgggcctg tacatagcgc acagatgttt   7999

 gttttaaata aataaacaaa atgtcaaaaa aaaaaaaa                           8037




      <210> 208
      <211> 1595
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(1537)

      <400> 208
 gctgacgacg atttcgtggc ggcgacggtg gaaggagcct ggctctggtg gcccccagaa     60

 gctctctggg cctggtggtc gggagaggga ctacattgca ccatgggaaa gagagagaag    120

 ggatgccagc gaagagacaa gcacttccgt c   atg cag aaa acc ccc atc atc     172
                                      Met Gln Lys Thr Pro Ile Ile
                                        1               5

 ctc tca aaa cct cca gca gag cgg tca aaa cag cca cca cct cca aca      220
 Leu Ser Lys Pro Pro Ala Glu Arg Ser Lys Gln Pro Pro Pro Pro Thr
          10                  15                  20

 gcc cct gct gcc ccg cct gct cca gcc cct ctg gag aag ccc atc gtt      268
 Ala Pro Ala Ala Pro Pro Ala Pro Ala Pro Leu Glu Lys Pro Ile Val
      25                  30                  35

 ctc atg aag cca cgg gag gag ggg aag ggg cct gtg gcc gtg aca ggt      316
 Leu Met Lys Pro Arg Glu Glu Gly Lys Gly Pro Val Ala Val Thr Gly
  40                  45                  50                  55

 gcc tct acc cct gag ggc acc gcc cca cca ccc cct gca gcc cct gcg      364
 Ala Ser Thr Pro Glu Gly Thr Ala Pro Pro Pro Pro Ala Ala Pro Ala
                  60                  65                  70

 cca ccc aag ggg gag aag gag ggg cag aga ccc aca cag cct gtg tac      412
 Pro Pro Lys Gly Glu Lys Glu Gly Gln Arg Pro Thr Gln Pro Val Tyr
              75                  80                  85

 cag atc cag aac cgg ggc atg ggc act gcc gca cca gca gcc atg gac      460
 Gln Ile Gln Asn Arg Gly Met Gly Thr Ala Ala Pro Ala Ala Met Asp
          90                  95                 100

 cct gtc gtg ggt cag gcc aaa cta ctg ccc cca gag cgc atg aag cac      508
 Pro Val Val Gly Gln Ala Lys Leu Leu Pro Pro Glu Arg Met Lys His
     105                 110                 115

 agc atc aag ttg gtg gat gac cag atg aat tgg tgt gac agt gcc atc      556
 Ser Ile Lys Leu Val Asp Asp Gln Met Asn Trp Cys Asp Ser Ala Ile
 120                 125                 130                 135

 gag tac ctg ttg gat cag act gat gtg ttg gtg gtt ggt gtc ctg ggc      604
 Glu Tyr Leu Leu Asp Gln Thr Asp Val Leu Val Val Gly Val Leu Gly
                 140                 145                 150

 ctc cag ggg aca ggc aag tcc atg gtc atg tca ttg ttg tca gcc aac      652
 Leu Gln Gly Thr Gly Lys Ser Met Val Met Ser Leu Leu Ser Ala Asn
             155                 160                 165

 act cca gag gag gac cag agg act tat gtt ttc cgg gcc cag agc gct      700
 Thr Pro Glu Glu Asp Gln Arg Thr Tyr Val Phe Arg Ala Gln Ser Ala
         170                 175                 180

 gaa atg aag gaa cga ggg ggc aac cag acc agt ggc atc gac ttc ttt      748
 Glu Met Lys Glu Arg Gly Gly Asn Gln Thr Ser Gly Ile Asp Phe Phe
     185                 190                 195

 att acc caa gaa cgg att gtt ttc ctg gac aca cag ccc atc ctg agc      796
 Ile Thr Gln Glu Arg Ile Val Phe Leu Asp Thr Gln Pro Ile Leu Ser
 200                 205                 210                 215

 cct tct atc cta gac cat ctc atc aat aat gac cgc aaa ctg cct cca      844
 Pro Ser Ile Leu Asp His Leu Ile Asn Asn Asp Arg Lys Leu Pro Pro
                 220                 225                 230

 gag tac aac ctt ccc cac act tac gtt gaa atg cag tca ctc cag att      892
 Glu Tyr Asn Leu Pro His Thr Tyr Val Glu Met Gln Ser Leu Gln Ile
             235                 240                 245

 gct gcc ttc ctt ttc acg gtc tgc cat gtg gtg att gtt gtc cag gac      940
 Ala Ala Phe Leu Phe Thr Val Cys His Val Val Ile Val Val Gln Asp
         250                 255                 260

 tgg ttc aca gac ctc agt ctc tac agg ttc ctg cag aca gca gag atg      988
 Trp Phe Thr Asp Leu Ser Leu Tyr Arg Phe Leu Gln Thr Ala Glu Met
     265                 270                 275

 gtg aag ccc tcc acc cca tcc ccc agc cat gag tcc agc agc tca tcg     1036
 Val Lys Pro Ser Thr Pro Ser Pro Ser His Glu Ser Ser Ser Ser Ser
 280                 285                 290                 295

 ggc tcc gat gaa ggc acc gag tac tac ccc cac cta gtc ttc ttg cag     1084
 Gly Ser Asp Glu Gly Thr Glu Tyr Tyr Pro His Leu Val Phe Leu Gln
                 300                 305                 310

 aac aaa gct cgc cga gag gac ttc tgt cct cgg aag ctg cag cag atg     1132
 Asn Lys Ala Arg Arg Glu Asp Phe Cys Pro Arg Lys Leu Gln Gln Met
             315                 320                 325

 cac ctg atg att gac cag ctc atg gcc cac tcc cac ctg cgt tac aag     1180
 His Leu Met Ile Asp Gln Leu Met Ala His Ser His Leu Arg Tyr Lys
         330                 335                 340

 gga act ctg tcc atg tta caa tgc aat gtc ttc ccg ggg ctt cca cct     1228
 Gly Thr Leu Ser Met Leu Gln Cys Asn Val Phe Pro Gly Leu Pro Pro
     345                 350                 355

 gac ttc ctg gac tct gag gtc aac tta ttc ctg gta ccc ttc atg gac     1276
 Asp Phe Leu Asp Ser Glu Val Asn Leu Phe Leu Val Pro Phe Met Asp
 360                 365                 370                 375

 agt gaa gca gag agt gaa aac cca cca aga gca gga cct ggt tcc agc     1324
 Ser Glu Ala Glu Ser Glu Asn Pro Pro Arg Ala Gly Pro Gly Ser Ser
                 380                 385                 390

 cca ctc ttc tcc ctg ctg cct ggg tat cgg ggc cac ccc agt ttc cag     1372
 Pro Leu Phe Ser Leu Leu Pro Gly Tyr Arg Gly His Pro Ser Phe Gln
             395                 400                 405

 tcc ttg gtg agc aag ctc cgg agc caa gtg atg tcc atg gcc cgg cca     1420
 Ser Leu Val Ser Lys Leu Arg Ser Gln Val Met Ser Met Ala Arg Pro
         410                 415                 420

 cag ctg tca cac acg atc ctc acc gag aag aac tgc aga gga ctc agg     1468
 Gln Leu Ser His Thr Ile Leu Thr Glu Lys Asn Cys Arg Gly Leu Arg
     425                 430                 435

 ctg atg ctg cca gca ggc cac tgg gga cac cag cta gat ata ctg ctg     1516
 Leu Met Leu Pro Ala Gly His Trp Gly His Gln Leu Asp Ile Leu Leu
 440                 445                 450                 455

 cag gga ggc ctt ctg ctc tag ga tgggctgcaa gatgggcctg gccaccagga     1569
 Gln Gly Gly Leu Leu Leu 
                 460

 atgcctgctg cttgtggctc tccaag                                        1595




      <210> 209
      <211> 2335
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(1253)

      <400> 209
 gcggcggccc ggccagcccg gcccggcccg gggccgcgtc ctgagagtca gccctcgccg     60

 ctgcagcctc ggcgcccggc cggccggcc  atg gag cgc ccc ccg ccc cgc gcc     113
                                  Met Glu Arg Pro Pro Pro Arg Ala
                                    1               5

 gcc ggc cgg gac ccc agt gcg ctg cgg gcc gag gcg ccg tgg ctg cgc      161
 Ala Gly Arg Asp Pro Ser Ala Leu Arg Ala Glu Ala Pro Trp Leu Arg
      10                  15                  20

 gcg gag ggt ccg ggg ccg cgc gcc gcg ccc gtg acg gtg ccc acg ccg      209
 Ala Glu Gly Pro Gly Pro Arg Ala Ala Pro Val Thr Val Pro Thr Pro
  25                  30                  35                  40

 ccg cag ggc tct tcc gtg ggc ggc ggc ttc gcg ggc ttg gag ttc gcg      257
 Pro Gln Gly Ser Ser Val Gly Gly Gly Phe Ala Gly Leu Glu Phe Ala
                  45                  50                  55

 cgg ccg cag gag tcg gag ccg cgg gcc tcg gac ctg ggg gcc ccc cgg      305
 Arg Pro Gln Glu Ser Glu Pro Arg Ala Ser Asp Leu Gly Ala Pro Arg
              60                  65                  70

 acg tgg acg ggg gcg gcg gcg ggg ccc cgg act ccg tcg gcg cac atc      353
 Thr Trp Thr Gly Ala Ala Ala Gly Pro Arg Thr Pro Ser Ala His Ile
          75                  80                  85

 ccc gtc cca gcg cag aga gcc acc cca gga aaa gcc cgg ctg gac gag      401
 Pro Val Pro Ala Gln Arg Ala Thr Pro Gly Lys Ala Arg Leu Asp Glu
      90                  95                 100

 gtc atg gct gcc gct gcc ctt aca agc ctg tcc acc agc cct ctc ctt      449
 Val Met Ala Ala Ala Ala Leu Thr Ser Leu Ser Thr Ser Pro Leu Leu
 105                 110                 115                 120

 ctg ggg gcc cca gtt gca gcc ttc agc cca gag cct ggc ctg gag ccc      497
 Leu Gly Ala Pro Val Ala Ala Phe Ser Pro Glu Pro Gly Leu Glu Pro
                 125                 130                 135

 tgg aag gag gcc ctg gtg cgg ccc cca ggc agc tac agc agc agc agc      545
 Trp Lys Glu Ala Leu Val Arg Pro Pro Gly Ser Tyr Ser Ser Ser Ser
             140                 145                 150

 aac agt gga gac tgg gga tgg gac ctg gcc agt gac cag tcc tct ccg      593
 Asn Ser Gly Asp Trp Gly Trp Asp Leu Ala Ser Asp Gln Ser Ser Pro
         155                 160                 165

 tcc acc ccg tca ccc cca ctg ccc ccc gag gca gcc cac ttt ctg ttt      641
 Ser Thr Pro Ser Pro Pro Leu Pro Pro Glu Ala Ala His Phe Leu Phe
     170                 175                 180

 ggg gag ccc acc ctg aga aaa agg aag agc ccg gcc cag gtc atg ttc      689
 Gly Glu Pro Thr Leu Arg Lys Arg Lys Ser Pro Ala Gln Val Met Phe
 185                 190                 195                 200

 cag tgt ctg tgg aag agc tgc ggg aag gtg ctg agc acg gcg tcg gcg      737
 Gln Cys Leu Trp Lys Ser Cys Gly Lys Val Leu Ser Thr Ala Ser Ala
                 205                 210                 215

 atg cag aga cac atc cgc ctg gtg cac ctg ggg agg cag gca gag cct      785
 Met Gln Arg His Ile Arg Leu Val His Leu Gly Arg Gln Ala Glu Pro
             220                 225                 230

 gat cag agt gat ggt gag gag gac ttc tac tac aca gag ctg gat gtt      833
 Asp Gln Ser Asp Gly Glu Glu Asp Phe Tyr Tyr Thr Glu Leu Asp Val
         235                 240                 245

 ggt gtg gac acg ctg acc gac ggg ctg tcc agc ctg act cca gtg tcc      881
 Gly Val Asp Thr Leu Thr Asp Gly Leu Ser Ser Leu Thr Pro Val Ser
     250                 255                 260

 ccc acg gcc tcc atg ccg cct gcc ttc ccc cgc ctg gag ctg cca gag      929
 Pro Thr Ala Ser Met Pro Pro Ala Phe Pro Arg Leu Glu Leu Pro Glu
 265                 270                 275                 280

 ctg ctg gag ccc cca gcc ctg cct agt ccc ctg cgg ccg cct gcc ccg      977
 Leu Leu Glu Pro Pro Ala Leu Pro Ser Pro Leu Arg Pro Pro Ala Pro
                 285                 290                 295

 ccc ctg ccc ccg ccc cct gtc ctg agc acc gtt gct aac ccc cag tcc     1025
 Pro Leu Pro Pro Pro Pro Val Leu Ser Thr Val Ala Asn Pro Gln Ser
             300                 305                 310

 tgt cac agt gac cgt gtc tac cag ggc tgc ctg acg ccc gcc cgc ctg     1073
 Cys His Ser Asp Arg Val Tyr Gln Gly Cys Leu Thr Pro Ala Arg Leu
         315                 320                 325

 gag ccg cag ccc acg gag gtc gga gcc tgc cca ccc gcc ttg tcc tcc     1121
 Glu Pro Gln Pro Thr Glu Val Gly Ala Cys Pro Pro Ala Leu Ser Ser
     330                 335                 340

 agg atc gga gtc acc ctg agg aag ccc cgc ggc gac gcg aag aag tgc     1169
 Arg Ile Gly Val Thr Leu Arg Lys Pro Arg Gly Asp Ala Lys Lys Cys
 345                 350                 355                 360

 cgg aag gtg tat ggc atg gag cgc cgg gac ctc tgg tgc aca gcc tgc     1217
 Arg Lys Val Tyr Gly Met Glu Arg Arg Asp Leu Trp Cys Thr Ala Cys
                 365                 370                 375

 cgc tgg aag aaa gcc tgc cag cgg ttc ctg gac taa gtcc ggctcgttca     1267
 Arg Trp Lys Lys Ala Cys Gln Arg Phe Leu Asp 
             380                 385

 agaacataag ctaccacctt ctccctcccc accccctcca ggcccggggc tgaaacagcc   1327

 cgaggacagc cccaggggct ggctttcacc agctgcaggg tctgctttta cttggggtgg   1387

 gggggcgggg ctgaccctga accctccccc ccgccaggtc ggggaggggt cccaccactc   1447

 aaagtgcctc taaagaaacc agctttttgc actaaagcca aaccacaccg ctgtcccctt   1507

 agccccaagg gccctggggg cagccaccct cccgcctgtc ggcccgtaga tttatcaagg   1567

 gtgttatggg cccagctttg gggggccagt cccgatgcac tttgaggggt gttggagagg   1627

 ggactccccc actcgcactt aactcaacgg ctctcgggcc ctggggctgt ttttaccatg   1687

 tttgtttttg aagctcaggt gtctcacgtc tgggctgcac caggcgaaga gagaaattaa   1747

 agatttgagg tttttcccag aagctttgtc gtgcctctcg gggaggatag gccctggggc   1807

 tggggccccg tcggtgggcc agctgggtgg aggtctggca cgctgccccc cacagagggg   1867

 gccgacgggt caacccgctt cggctcgctc gccacgctcc ccggcgatgg ccgcgaggga   1927

 gaggagtcac tctgatgacg ccacggaggg caatcctttc tgggagcacg ccagtgttcc   1987

 ccacatttat ttgtgaacgt gattcgcctt ttgcacaagg atgttctata gctatatctc   2047

 cgctcaccac gagaaaggta atacgcacac acggcgccct acggcacgaa acattggagg   2107

 aactcacccg ccacgagggc ccaccgtggt atcccaccgg ccacacacga agagggcacg   2167

 gagcggcacg agccctgagt ttccccccga cgcgagttac gagagacctt ttcccccgca   2227

 tagtagacac atttcccata ccaaccccgg gttataataa gtaataggga gtccatataa   2287

 tatagattat cccccaggaa aaaatccacc atcttccaaa aaaaaaaa                2335




      <210> 210
      <211> 3366
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(2568)

      <400> 210
 gaaaagagaa atatc atg ttt atg caa gag ctt cag tat ttg ttt gct cta      51
                  Met Phe Met Gln Glu Leu Gln Tyr Leu Phe Ala Leu
                    1               5                  10

 atg atg gga tca aat aga aaa ttt gta gac ccg tct gca gcc ctg gat       99
 Met Met Gly Ser Asn Arg Lys Phe Val Asp Pro Ser Ala Ala Leu Asp
          15                  20                  25

 cta tta aag gga gca ttc cga tca tct gag gaa cag cag atc ata cct      147
 Leu Leu Lys Gly Ala Phe Arg Ser Ser Glu Glu Gln Gln Ile Ile Pro
      30                  35                  40

 ggc tct ttg ggg gtt gat gaa aat gca cta ttt ttg ctt ttg aat gat      195
 Gly Ser Leu Gly Val Asp Glu Asn Ala Leu Phe Leu Leu Leu Asn Asp
  45                  50                  55                  60

 gct tgg att tta tgt agc aca tat ctt aat cca aac aat cca gaa ttg      243
 Ala Trp Ile Leu Cys Ser Thr Tyr Leu Asn Pro Asn Asn Pro Glu Leu
                  65                  70                  75

 tct cct ttt cct aaa agc agc agt ccc agg aac aaa tct gaa aat cca      291
 Ser Pro Phe Pro Lys Ser Ser Ser Pro Arg Asn Lys Ser Glu Asn Pro
              80                  85                  90

 atg gtg cag ctg ttc tat ggt act ttc ctg act gaa ggg gtt cgt gaa      339
 Met Val Gln Leu Phe Tyr Gly Thr Phe Leu Thr Glu Gly Val Arg Glu
          95                 100                 105

 gga aaa ccc ttt tgt aac aat gag acc ttc ggc cag tat cct ctt cag      387
 Gly Lys Pro Phe Cys Asn Asn Glu Thr Phe Gly Gln Tyr Pro Leu Gln
     110                 115                 120

 gta aac ggt tat cgc aac tta gac gag tgt ttg gaa ggg gcc atg gtg      435
 Val Asn Gly Tyr Arg Asn Leu Asp Glu Cys Leu Glu Gly Ala Met Val
 125                 130                 135                 140

 gag ggt gat gtt gag ctt ctt ccc tcc gat cac tcg gtg aag tat gga      483
 Glu Gly Asp Val Glu Leu Leu Pro Ser Asp His Ser Val Lys Tyr Gly
                 145                 150                 155

 caa gag cgt tgg ttt aca aag cta cct cca gtg ttg acc ttt gaa ctc      531
 Gln Glu Arg Trp Phe Thr Lys Leu Pro Pro Val Leu Thr Phe Glu Leu
             160                 165                 170

 tca aga ttt gag ttt aat cag tcc ctt ggg cag cca gag aaa att cac      579
 Ser Arg Phe Glu Phe Asn Gln Ser Leu Gly Gln Pro Glu Lys Ile His
         175                 180                 185

 aat aag ctg gaa ttt cct cag att att tat atg gac agg tac atg tac      627
 Asn Lys Leu Glu Phe Pro Gln Ile Ile Tyr Met Asp Arg Tyr Met Tyr
     190                 195                 200

 agg agc aag gag ctt att cga aat aag aga gag tgt att cga aag ttg      675
 Arg Ser Lys Glu Leu Ile Arg Asn Lys Arg Glu Cys Ile Arg Lys Leu
 205                 210                 215                 220

 aag gag gaa ata aaa att ctg cag caa aaa ttg gaa agg tat gtg aaa      723
 Lys Glu Glu Ile Lys Ile Leu Gln Gln Lys Leu Glu Arg Tyr Val Lys
                 225                 230                 235

 tat ggc tca ggc cca gct cgg ttc ccg ctc ccg gac atg ctg aaa tat      771
 Tyr Gly Ser Gly Pro Ala Arg Phe Pro Leu Pro Asp Met Leu Lys Tyr
             240                 245                 250

 gtt att gaa ttt gct agt aca aaa cct gcc tca gaa agc tgt cca cct      819
 Val Ile Glu Phe Ala Ser Thr Lys Pro Ala Ser Glu Ser Cys Pro Pro
         255                 260                 265

 gaa agt gac aca cat atg aca tta cca ctt tct tca gtg cac tgc tcg      867
 Glu Ser Asp Thr His Met Thr Leu Pro Leu Ser Ser Val His Cys Ser
     270                 275                 280

 gtt tct gac cag aca tcc aag gaa agt aca agt aca gaa agc tct tct      915
 Val Ser Asp Gln Thr Ser Lys Glu Ser Thr Ser Thr Glu Ser Ser Ser
 285                 290                 295                 300

 cag gat gtt gaa agt acc ttt tct tct cct gaa gat tct tta ccc aag      963
 Gln Asp Val Glu Ser Thr Phe Ser Ser Pro Glu Asp Ser Leu Pro Lys
                 305                 310                 315

 tct aaa cca ctg aca tct tct cgg tct tcc atg gaa atg cct tca cag     1011
 Ser Lys Pro Leu Thr Ser Ser Arg Ser Ser Met Glu Met Pro Ser Gln
             320                 325                 330

 cca gct cca cga aca gtc aca gat gag gag ata aat ttt gtt aag acc     1059
 Pro Ala Pro Arg Thr Val Thr Asp Glu Glu Ile Asn Phe Val Lys Thr
         335                 340                 345

 tgt ctt cag aga tgg agg agt gag att gaa caa gat ata caa gat tta     1107
 Cys Leu Gln Arg Trp Arg Ser Glu Ile Glu Gln Asp Ile Gln Asp Leu
     350                 355                 360

 aag act tgt att gca agt act act cag act att gaa cag atg tac tgc     1155
 Lys Thr Cys Ile Ala Ser Thr Thr Gln Thr Ile Glu Gln Met Tyr Cys
 365                 370                 375                 380

 gat cct ctc ctt cgt cag gtg cct tat cgc ttg cat gca gtt ctt gtt     1203
 Asp Pro Leu Leu Arg Gln Val Pro Tyr Arg Leu His Ala Val Leu Val
                 385                 390                 395

 cat gaa gga caa gca aat gct gga cac tat tgg gcc tat atc tat aat     1251
 His Glu Gly Gln Ala Asn Ala Gly His Tyr Trp Ala Tyr Ile Tyr Asn
             400                 405                 410

 caa ccc cga cag agc tgg ctc aag tac aat gac atc tct gtt act gaa     1299
 Gln Pro Arg Gln Ser Trp Leu Lys Tyr Asn Asp Ile Ser Val Thr Glu
         415                 420                 425

 tct tcc tgg gaa gaa gtt gaa aga gat tcc tat gga ggc ctg aga aat     1347
 Ser Ser Trp Glu Glu Val Glu Arg Asp Ser Tyr Gly Gly Leu Arg Asn
     430                 435                 440

 gtt agt gct tac tgt ctg atg tac att aat gac aaa cta ccc tac ttc     1395
 Val Ser Ala Tyr Cys Leu Met Tyr Ile Asn Asp Lys Leu Pro Tyr Phe
 445                 450                 455                 460

 aat gca gag gca gcc cca act gaa tca gat caa atg tca gaa gtg gaa     1443
 Asn Ala Glu Ala Ala Pro Thr Glu Ser Asp Gln Met Ser Glu Val Glu
                 465                 470                 475

 gcc cta tct gtg gaa ctc aag cat tac att cag gag gat aac tgg cgg     1491
 Ala Leu Ser Val Glu Leu Lys His Tyr Ile Gln Glu Asp Asn Trp Arg
             480                 485                 490

 ttt gag cag gaa gta gag gag tgg gaa gaa gag cag tct tgc aaa atc     1539
 Phe Glu Gln Glu Val Glu Glu Trp Glu Glu Glu Gln Ser Cys Lys Ile
         495                 500                 505

 cct caa atg gag tcc tcc acc aac tcc tca tca cag gac tac tct aca     1587
 Pro Gln Met Glu Ser Ser Thr Asn Ser Ser Ser Gln Asp Tyr Ser Thr
     510                 515                 520

 tca caa gag cct tca gta gcc tct tct cat ggg gtt cgc tgc ttg tca     1635
 Ser Gln Glu Pro Ser Val Ala Ser Ser His Gly Val Arg Cys Leu Ser
 525                 530                 535                 540

 tct gag cat gct gtg att gta aag gag caa act gcc cag gct att gca     1683
 Ser Glu His Ala Val Ile Val Lys Glu Gln Thr Ala Gln Ala Ile Ala
                 545                 550                 555

 aac aca gcc cgt gcc tat gag aag agc ggt gta gaa gcg gca ctg agt     1731
 Asn Thr Ala Arg Ala Tyr Glu Lys Ser Gly Val Glu Ala Ala Leu Ser
             560                 565                 570

 gag gca ttc cat gaa gaa tac tcc agg ctc tat cag ctt gcc aaa gag     1779
 Glu Ala Phe His Glu Glu Tyr Ser Arg Leu Tyr Gln Leu Ala Lys Glu
         575                 580                 585

 acc ccc acc tct cac agt gat cct cga ctt cag cat gtc ctt gtc tac     1827
 Thr Pro Thr Ser His Ser Asp Pro Arg Leu Gln His Val Leu Val Tyr
     590                 595                 600

 ttt ttc caa aat gaa gca ccc aaa agg gta gta gaa cga acc ctt ctg     1875
 Phe Phe Gln Asn Glu Ala Pro Lys Arg Val Val Glu Arg Thr Leu Leu
 605                 610                 615                 620

 gaa cag ttt gca gat aaa aat ctt agc tat gat gaa aga tca atc agc     1923
 Glu Gln Phe Ala Asp Lys Asn Leu Ser Tyr Asp Glu Arg Ser Ile Ser
                 625                 630                 635

 att atg aag gtg gct caa gcg aaa ctg aag gaa att ggt cca gat gac     1971
 Ile Met Lys Val Ala Gln Ala Lys Leu Lys Glu Ile Gly Pro Asp Asp
             640                 645                 650

 atg aat atg gaa gag tac aag aag tgg cat gaa gat tat agt ttg ttc     2019
 Met Asn Met Glu Glu Tyr Lys Lys Trp His Glu Asp Tyr Ser Leu Phe
         655                 660                 665

 cga aaa gtg tct gtg tat ctc cta aca ggc cta gaa ctc tat caa aaa     2067
 Arg Lys Val Ser Val Tyr Leu Leu Thr Gly Leu Glu Leu Tyr Gln Lys
     670                 675                 680

 gga aag tac caa gag gca ctt tcc tac ctg gta tat gcc tac cag agc     2115
 Gly Lys Tyr Gln Glu Ala Leu Ser Tyr Leu Val Tyr Ala Tyr Gln Ser
 685                 690                 695                 700

 aat gct gcc ctg ctg atg aag ggg ccc cgc cgg ggg gtc aaa gaa tcc     2163
 Asn Ala Ala Leu Leu Met Lys Gly Pro Arg Arg Gly Val Lys Glu Ser
                 705                 710                 715

 gtg att gct tta tac cga aga aaa tgc ctt ctg gag ctg aat gcc aaa     2211
 Val Ile Ala Leu Tyr Arg Arg Lys Cys Leu Leu Glu Leu Asn Ala Lys
             720                 725                 730

 gca gct tct ctt ttt gaa aca aat gat gat cac tcc gta act gag ggc     2259
 Ala Ala Ser Leu Phe Glu Thr Asn Asp Asp His Ser Val Thr Glu Gly
         735                 740                 745

 att aat gtg atg aat gaa ctg atc atc ccc tgc att cac ctt atc att     2307
 Ile Asn Val Met Asn Glu Leu Ile Ile Pro Cys Ile His Leu Ile Ile
     750                 755                 760

 aat aat gac att tcc aag gat gat ctg gat gcc att gag gtc atg aga     2355
 Asn Asn Asp Ile Ser Lys Asp Asp Leu Asp Ala Ile Glu Val Met Arg
 765                 770                 775                 780

 aac cat tgg tgc tct tac ctt ggg caa gat att gca gaa aat ctg cag     2403
 Asn His Trp Cys Ser Tyr Leu Gly Gln Asp Ile Ala Glu Asn Leu Gln
                 785                 790                 795

 ctg tgc cta ggg gag ttt cta ccc aga ctt cta gat cct tct gca gaa     2451
 Leu Cys Leu Gly Glu Phe Leu Pro Arg Leu Leu Asp Pro Ser Ala Glu
             800                 805                 810

 atc atc gtc ttg aaa gag cct cca act att cga ccc aat tct ccc tat     2499
 Ile Ile Val Leu Lys Glu Pro Pro Thr Ile Arg Pro Asn Ser Pro Tyr
         815                 820                 825

 gac cta tgt agc cga ttt gca gct gtc atg gag tca att cag gga gtt     2547
 Asp Leu Cys Ser Arg Phe Ala Ala Val Met Glu Ser Ile Gln Gly Val
     830                 835                 840

 tca act gtg aca gtg aaa taa gc tcccacatgt tcaaggccca ttctggttcc     2600
 Ser Thr Val Thr Val Lys 
 845                 850

 tggctgcctg cctcttgcac agaagttcgt tgtcatagtg ctcaccttgg gaaaaggatt   2660

 aggtgggcac ataagattcc gatcagaccc caaccatgct gcatgtgtaa agaaggattg   2720

 aaaataaaat tgcacttttt aggtacaaaa tcataaaagc tgtttcacta gaaaaggcag   2780

 aaagcagtgt attaaggtgt tgaattacgc cagaagacct gaaatgcctt gtacctacaa   2840

 caatgcttag gcttttctaa gcctcttgcc acttttaaaa ttatccttca ggcataaata   2900

 tttttgacag cagaatagaa gaatgattca tgagaacctg aaccagatga acagctacta   2960

 gttattttat caaatacaga tgacatttaa aaattcttaa ctacaagaga ttagaaatat   3020

 aaaccttgcc tggctcttgc caggagataa caaaatgggt tgctgatgaa ctgcaccctt   3080

 ttacatgtgg gtagaatata agctcacatg gcagtgagat gttgaaaagt caaaagagac   3140

 ctgtctctct cctttctttt ctatctttaa accagaaaac ctcatactca gtcctcagtg   3200

 aaagaaagta aagtattaag gactttagac agaagagcat tgtgtaactt gactgaagat   3260

 catccattaa tagttattag gcatttaggt aaaattttct aatacctaaa aattgtcaaa   3320

 aacagtcaat agggctactg ctggcccaaa gaccatttag gtccac                  3366




      <210> 211
      <211> 1280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (12)..(1061)

      <400> 211
 gagccaagac c atg gcg aaa gcc ggg gat aag agc agc agc agc ggg aag      50
              Met Ala Lys Ala Gly Asp Lys Ser Ser Ser Ser Gly Lys
                1               5                  10

 aaa agt cta aaa cgg aaa gcc gct gcc gaa gaa ctt cag gag gct gca       98
 Lys Ser Leu Lys Arg Lys Ala Ala Ala Glu Glu Leu Gln Glu Ala Ala
      15                  20                  25

 ggc gct ggg gat ggg gcg acg gaa aac ggg gtc caa ccc ccg aaa gcg      146
 Gly Ala Gly Asp Gly Ala Thr Glu Asn Gly Val Gln Pro Pro Lys Ala
  30                  35                  40                  45

 gct gcc ttt ccg cca ggc ttt agc att tcg gag att aaa aac aaa cag      194
 Ala Ala Phe Pro Pro Gly Phe Ser Ile Ser Glu Ile Lys Asn Lys Gln
                  50                  55                  60

 cgg cga cac tta atg ttc acg cgg tgg aaa cag cag cag cgg aag gaa      242
 Arg Arg His Leu Met Phe Thr Arg Trp Lys Gln Gln Gln Arg Lys Glu
              65                  70                  75

 aag ttg gca gct aag aaa aaa ctt aaa aaa gaa aga gag gct ctt ggc      290
 Lys Leu Ala Ala Lys Lys Lys Leu Lys Lys Glu Arg Glu Ala Leu Gly
          80                  85                  90

 gat aag gct cca cca aag cct gta ccc aag acc att gac aac cag cga      338
 Asp Lys Ala Pro Pro Lys Pro Val Pro Lys Thr Ile Asp Asn Gln Arg
      95                 100                 105

 gtg tat gat gaa acc aca gta gac cct aat gat gaa gag gtc gct tat      386
 Val Tyr Asp Glu Thr Thr Val Asp Pro Asn Asp Glu Glu Val Ala Tyr
 110                 115                 120                 125

 gat gaa gct aca gat gaa ttt gct tct tac ttc aac aaa cag act tct      434
 Asp Glu Ala Thr Asp Glu Phe Ala Ser Tyr Phe Asn Lys Gln Thr Ser
                 130                 135                 140

 ccc aag att ctc atc aca aca tca gat aga cct cat ggg aga aca gta      482
 Pro Lys Ile Leu Ile Thr Thr Ser Asp Arg Pro His Gly Arg Thr Val
             145                 150                 155

 cga ctc tgt gaa cag ctc tcc aca gtt ata cca aac tca cat gtt tat      530
 Arg Leu Cys Glu Gln Leu Ser Thr Val Ile Pro Asn Ser His Val Tyr
         160                 165                 170

 tac aga aga gga ctg gct ctg aaa aaa att att cca cag tgc atc gca      578
 Tyr Arg Arg Gly Leu Ala Leu Lys Lys Ile Ile Pro Gln Cys Ile Ala
     175                 180                 185

 aga gat ttc aca gac ctg att gtt att aat gaa gat cgt aaa acc cca      626
 Arg Asp Phe Thr Asp Leu Ile Val Ile Asn Glu Asp Arg Lys Thr Pro
 190                 195                 200                 205

 aat gga ctt att ttg agt cac ttg cca aat ggc cca act gct cat ttt      674
 Asn Gly Leu Ile Leu Ser His Leu Pro Asn Gly Pro Thr Ala His Phe
                 210                 215                 220

 aaa atg agc agt gtt cgt ctt cgt aaa gaa att aag aga aga ggc aag      722
 Lys Met Ser Ser Val Arg Leu Arg Lys Glu Ile Lys Arg Arg Gly Lys
             225                 230                 235

 gac ccc aca gaa cac ata cct gaa ata att ctg aat aat ttt aca aca      770
 Asp Pro Thr Glu His Ile Pro Glu Ile Ile Leu Asn Asn Phe Thr Thr
         240                 245                 250

 cgg ctg ggt cat tca att gga cgt atg ttt gca tct ctc ttt cct cat      818
 Arg Leu Gly His Ser Ile Gly Arg Met Phe Ala Ser Leu Phe Pro His
     255                 260                 265

 aat cct caa ttt atc gga agg cag gtt gcc aca ttc cac aat caa cgg      866
 Asn Pro Gln Phe Ile Gly Arg Gln Val Ala Thr Phe His Asn Gln Arg
 270                 275                 280                 285

 gat tac ata ttc ttc aga ttt cac aga tac ata ttc agg agt gaa aag      914
 Asp Tyr Ile Phe Phe Arg Phe His Arg Tyr Ile Phe Arg Ser Glu Lys
                 290                 295                 300

 aaa gtg gga att cag gaa ctt gga cca cgt ttt acc tta aaa tta agg      962
 Lys Val Gly Ile Gln Glu Leu Gly Pro Arg Phe Thr Leu Lys Leu Arg
             305                 310                 315

 tct ctt cag aaa gga acc ttt gat tct aaa tat gga gag tat gaa tgg     1010
 Ser Leu Gln Lys Gly Thr Phe Asp Ser Lys Tyr Gly Glu Tyr Glu Trp
         320                 325                 330

 gtc cat aag ccc cgg gaa atg gat aca agt aga aga aaa ttc cat tta     1058
 Val His Lys Pro Arg Glu Met Asp Thr Ser Arg Arg Lys Phe His Leu
     335                 340                 345

 taa agta ctgagagaat gatattggat tttgctgaac aggcctatct tgaactttgg     1115
 


 taaattattt ttgacagaat actcttttca aaatggcatt tgctgatttc ataaaccttt   1175

 cacgtctgga cgaattacca aatgccatga attgccactg tgtgtttatg tagaaaatac   1235

 aaataaaagt tattttgatg gcttaggttt ccttaaaaaa aaaaa                   1280




      <210> 212
      <211> 1839
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(1385)

      <400> 212
 gaattcgcgc gagcgctgcg ccagatctcg gtctgatgga cgcctggtgt ggacgatgag     60

 ggaagaacgt gccccccaca cccaagaggt gacccctgag ccagccccgg   atg acc     116
                                                          Met Thr
                                                            1

 ctg cga cct gga aca atg cgg ctg gcc tgc atg ttc tct tcc atc ctg      164
 Leu Arg Pro Gly Thr Met Arg Leu Ala Cys Met Phe Ser Ser Ile Leu
           5                  10                  15

 ctg ttc gga gct gca ggc ctc ctc ctc ttc atc agc ctg cag gac cct      212
 Leu Phe Gly Ala Ala Gly Leu Leu Leu Phe Ile Ser Leu Gln Asp Pro
      20                  25                  30

 acg gag ctc gcc ccc cag cag gtg cca gga ata aag ttc aac atc agg      260
 Thr Glu Leu Ala Pro Gln Gln Val Pro Gly Ile Lys Phe Asn Ile Arg
  35                  40                  45                  50

 cca agg cag ccc cac cac gac ctc cca cca ggc ggc tcc cag gat ggt      308
 Pro Arg Gln Pro His His Asp Leu Pro Pro Gly Gly Ser Gln Asp Gly
                  55                  60                  65

 gac ttg aag gaa ccc aca gag agg gtc act cgg gac tta tcc agt ggg      356
 Asp Leu Lys Glu Pro Thr Glu Arg Val Thr Arg Asp Leu Ser Ser Gly
              70                  75                  80

 gcc ccg agg ggc cgc aac ctg cca gcg cct gac cag cct caa ccc ccg      404
 Ala Pro Arg Gly Arg Asn Leu Pro Ala Pro Asp Gln Pro Gln Pro Pro
          85                  90                  95

 ctg cag agg gga acc cgt ctg cgg ctc cgc cag cgc cgt cgc cgt ctg      452
 Leu Gln Arg Gly Thr Arg Leu Arg Leu Arg Gln Arg Arg Arg Arg Leu
     100                 105                 110

 ctc atc aag aaa atg cca gct gcg gcg acc atc ccg gcc aac agc tcg      500
 Leu Ile Lys Lys Met Pro Ala Ala Ala Thr Ile Pro Ala Asn Ser Ser
 115                 120                 125                 130

 gac gcg ccc ttc atc cgg ccg gga ccc ggg acg ctg gat ggc cgc tgg      548
 Asp Ala Pro Phe Ile Arg Pro Gly Pro Gly Thr Leu Asp Gly Arg Trp
                 135                 140                 145

 gtc agc ctg cac cgg agc cag cag gag cgc aag cgg gtg atg cag gag      596
 Val Ser Leu His Arg Ser Gln Gln Glu Arg Lys Arg Val Met Gln Glu
             150                 155                 160

 gcc tgc gcc aag tac cgg gcg agc agc agc cgc cgg gcc gtc acg ccc      644
 Ala Cys Ala Lys Tyr Arg Ala Ser Ser Ser Arg Arg Ala Val Thr Pro
         165                 170                 175

 cgc cac gtg tcc cgt atc ttc gtg gag gac cgc cac cgc gtg ctc tac      692
 Arg His Val Ser Arg Ile Phe Val Glu Asp Arg His Arg Val Leu Tyr
     180                 185                 190

 tgc gag gtg ccc aag gcc ggc tgc tcc aat tgg aag cgg gtg ctc atg      740
 Cys Glu Val Pro Lys Ala Gly Cys Ser Asn Trp Lys Arg Val Leu Met
 195                 200                 205                 210

 gtg ctg gcc ggc ctg gcc tcg tcc act gcc gac atc cag cac aac acc      788
 Val Leu Ala Gly Leu Ala Ser Ser Thr Ala Asp Ile Gln His Asn Thr
                 215                 220                 225

 gtc cac tat ggc agc gct ctc aag cgc ctg gac acc ttc gac cgc cag      836
 Val His Tyr Gly Ser Ala Leu Lys Arg Leu Asp Thr Phe Asp Arg Gln
             230                 235                 240

 ggt atc ttg cac cgt ctc agc acc tac acc aag atg ctc ttt gtc cgc      884
 Gly Ile Leu His Arg Leu Ser Thr Tyr Thr Lys Met Leu Phe Val Arg
         245                 250                 255

 gag ccc ttc gag agg ctg gtg tcc gcc ttc cgc gac aag ttt gag cac      932
 Glu Pro Phe Glu Arg Leu Val Ser Ala Phe Arg Asp Lys Phe Glu His
     260                 265                 270

 ccc aac agc tac tat cac ccg gtc ttc ggc aag gcc atc ctg gcc cgg      980
 Pro Asn Ser Tyr Tyr His Pro Val Phe Gly Lys Ala Ile Leu Ala Arg
 275                 280                 285                 290

 tac cgc gcc aat gcc tct cgg gag gcc ctg cgg acc ggc tct ggg gtg     1028
 Tyr Arg Ala Asn Ala Ser Arg Glu Ala Leu Arg Thr Gly Ser Gly Val
                 295                 300                 305

 cgt ttt ccc gag ttc gtc cag tac ctg ctg gac gtg cac cgg ccc gtg     1076
 Arg Phe Pro Glu Phe Val Gln Tyr Leu Leu Asp Val His Arg Pro Val
             310                 315                 320

 ggg atg gac att cac tgg gac cat gtc agc cgg ctc tgc agc ccc tgc     1124
 Gly Met Asp Ile His Trp Asp His Val Ser Arg Leu Cys Ser Pro Cys
         325                 330                 335

 ctc atc gac tac gat ttc gta ggc aag ttc gag agc atg gag gac gat     1172
 Leu Ile Asp Tyr Asp Phe Val Gly Lys Phe Glu Ser Met Glu Asp Asp
     340                 345                 350

 gcc aac ttc ttc ctg agc ctc atc cgc gcg ccg cgg aac ctg acc ttc     1220
 Ala Asn Phe Phe Leu Ser Leu Ile Arg Ala Pro Arg Asn Leu Thr Phe
 355                 360                 365                 370

 ccc cgg ttc aag gac cgg cac tcg cag gag gcg cgg acc aca gcg agg     1268
 Pro Arg Phe Lys Asp Arg His Ser Gln Glu Ala Arg Thr Thr Ala Arg
                 375                 380                 385

 atc gcc cac cag tac ttc gcc caa ctc tcg gcc ctg caa agg cag cgc     1316
 Ile Ala His Gln Tyr Phe Ala Gln Leu Ser Ala Leu Gln Arg Gln Arg
             390                 395                 400

 acc tac gac ttc tac tac atg gat tac ctg atg ttc aac tat tcc aag     1364
 Thr Tyr Asp Phe Tyr Tyr Met Asp Tyr Leu Met Phe Asn Tyr Ser Lys
         405                 410                 415

 ccc ttt gca gat ctg tac tga gg ggcgccgcag ctggccgggg ccgccctgcc     1417
 Pro Phe Ala Asp Leu Tyr 
     420

 ccggtcactc acctgtgctc ccgggcatcc tcctgtccct ggctcctcat cctgggagca   1477

 acagggctct gaggacgtga ggagccatcg ctgtgggagg cagcaggccc cgggtggggg   1537

 gcagaggcgc ccagccttgg atggggaccc cagcccctgg cctgtacctg tttcctcatt   1597

 ccttggctga gggagaggct gagaactggg cagacacccc tggagctcag ccgacagttt   1657

 tgatgagcag ggaagtctga ggcccagagg acggggggcc cagcggtaag ggatgtcccg   1717

 cactccctta gccattgcct tggaccaaac cacgtggttt gcagcttttc tacgagccag   1777

 gggggaggtt cccttggatt aaggttccaa ataaagcaca tggtttccag aaaaaaaaaa   1837

 aa                                                                  1839




      <210> 213
      <211> 955
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(810)

      <400> 213
 tttcgtccgg cctccctccc tccctcgccc gcccggcgct cgcagagccg acaccagggg     60

 ggctctcgat gtagcacc  atg aca ggc atc gcc gcc gcc tcc ttc ttc tcc     111
                      Met Thr Gly Ile Ala Ala Ala Ser Phe Phe Ser
                        1               5                  10

 aat acc tgc cga ttc ggg ggc tgc gga ctc cac ttc ccc acc ctg gcc      159
 Asn Thr Cys Arg Phe Gly Gly Cys Gly Leu His Phe Pro Thr Leu Ala
              15                  20                  25

 gac ctc atc gag cac atc gag gac aac cac atc gat aca gat cca cgg      207
 Asp Leu Ile Glu His Ile Glu Asp Asn His Ile Asp Thr Asp Pro Arg
          30                  35                  40

 gtt tta gaa aaa caa gaa tta cag cag cca acc tat gtt gcc ctg agt      255
 Val Leu Glu Lys Gln Glu Leu Gln Gln Pro Thr Tyr Val Ala Leu Ser
      45                  50                  55

 tac ata aat aga ttc atg aca gat gct gcc cgc cga gag cag gag tcc      303
 Tyr Ile Asn Arg Phe Met Thr Asp Ala Ala Arg Arg Glu Gln Glu Ser
  60                  65                  70                  75

 cta aag aag aag att cag ccg aag ctc tcg ctg act ctg tcc agc tca      351
 Leu Lys Lys Lys Ile Gln Pro Lys Leu Ser Leu Thr Leu Ser Ser Ser
                  80                  85                  90

 gtg tct cga ggg aat gtg tcc act ccc cca cgc cac agc agt gga agc      399
 Val Ser Arg Gly Asn Val Ser Thr Pro Pro Arg His Ser Ser Gly Ser
              95                 100                 105

 ctt act ccc ccc gtg acc cca ccc atc acc ccc tcc tct tca ttc cgc      447
 Leu Thr Pro Pro Val Thr Pro Pro Ile Thr Pro Ser Ser Ser Phe Arg
         110                 115                 120

 agc agc act ccg aca ggc agc gag tat gac gag gag gag gtg gac tat      495
 Ser Ser Thr Pro Thr Gly Ser Glu Tyr Asp Glu Glu Glu Val Asp Tyr
     125                 130                 135

 gag gag tcg gac agc gat gag tcc tgg acc aca gag agt gcc atc agc      543
 Glu Glu Ser Asp Ser Asp Glu Ser Trp Thr Thr Glu Ser Ala Ile Ser
 140                 145                 150                 155

 tcc gaa gcc atc ctc agc tcc atg tgc atg aat gga ggg gaa gag aag      591
 Ser Glu Ala Ile Leu Ser Ser Met Cys Met Asn Gly Gly Glu Glu Lys
                 160                 165                 170

 cct ttt gcc tgc cca gtt cct gga tgt aaa aag aga tac aag aat gtg      639
 Pro Phe Ala Cys Pro Val Pro Gly Cys Lys Lys Arg Tyr Lys Asn Val
             175                 180                 185

 aat ggc ata aag tat cac gct aag aat ggt cac aga aca cag att cgt      687
 Asn Gly Ile Lys Tyr His Ala Lys Asn Gly His Arg Thr Gln Ile Arg
         190                 195                 200

 gtc cgc aaa cca ttc aag tgt cgc tgt ggg aag agt tac aag aca gct      735
 Val Arg Lys Pro Phe Lys Cys Arg Cys Gly Lys Ser Tyr Lys Thr Ala
     205                 210                 215

 cag ggc ctg cgg cac cac aca atc aat ttc cat ccc ccg gtg tcg gct      783
 Gln Gly Leu Arg His His Thr Ile Asn Phe His Pro Pro Val Ser Ala
 220                 225                 230                 235

 gag att atc agg aag atg cag caa taa catgc tggtcataac tgtgccaaga      835
 Glu Ile Ile Arg Lys Met Gln Gln 
                 240

 aatcctcacc agcagttgct gattttgaaa acagccacct tttttcaggg gaagcattca    895

 gcaacccttt aaagaaaaag aattaaatgc atgctttaaa ttttttctgt aaaaaaaaaa    955




      <210> 214
      <211> 1194
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(648)

      <400> 214
  atg gcg gat tcc tcg ccc gca ctg tcc ctg cgg gaa ggc ggc ccc cgc      48
  Met Ala Asp Ser Ser Pro Ala Leu Ser Leu Arg Glu Gly Gly Pro Arg
    1               5                  10                  15

 gcg ccg cgg ccc tcg gcc ccc tcg ccg ccg ccg cgc tcg cgc tcc ggc       96
 Ala Pro Arg Pro Ser Ala Pro Ser Pro Pro Pro Arg Ser Arg Ser Gly
              20                  25                  30

 tcc gag tcc gag gag gcc gag ctg tcg ctg agc ctg gcc cgc acc aag      144
 Ser Glu Ser Glu Glu Ala Glu Leu Ser Leu Ser Leu Ala Arg Thr Lys
          35                  40                  45

 acc cgc tcg tac ggc agc acc gcc agc gtg cgg gcg ccg ctg ggc gcc      192
 Thr Arg Ser Tyr Gly Ser Thr Ala Ser Val Arg Ala Pro Leu Gly Ala
      50                  55                  60

 ggc gtc atc gag cgc cat gtg gag cac cgg gtc cgc gcg ggc gac acg      240
 Gly Val Ile Glu Arg His Val Glu His Arg Val Arg Ala Gly Asp Thr
  65                  70                  75                  80

 ctg cag ggc atc gcg ctc aag tac ggt gtc acg atg gaa cag att aaa      288
 Leu Gln Gly Ile Ala Leu Lys Tyr Gly Val Thr Met Glu Gln Ile Lys
                  85                  90                  95

 agg gcc aat aaa ctg ttt acc aat gat tgt ata ttt ctg aag aaa act      336
 Arg Ala Asn Lys Leu Phe Thr Asn Asp Cys Ile Phe Leu Lys Lys Thr
             100                 105                 110

 ttg aac atc cca gtt ata tca gag aag cct ttg ttg ttt aat gga ctt      384
 Leu Asn Ile Pro Val Ile Ser Glu Lys Pro Leu Leu Phe Asn Gly Leu
         115                 120                 125

 aac tcc att gat tct cca gaa aat gaa act gct gat aac agt ttt tct      432
 Asn Ser Ile Asp Ser Pro Glu Asn Glu Thr Ala Asp Asn Ser Phe Ser
     130                 135                 140

 cag gaa gag gag cca gtg gtg gcc ggg gaa gac ctc cct cct ccc agt      480
 Gln Glu Glu Glu Pro Val Val Ala Gly Glu Asp Leu Pro Pro Pro Ser
 145                 150                 155                 160

 cct caa gaa tct gat gtt cag cct gtg cag cct gag gaa gtg tca gcc      528
 Pro Gln Glu Ser Asp Val Gln Pro Val Gln Pro Glu Glu Val Ser Ala
                 165                 170                 175

 aga gat ttc ctg cag aga ctt gac ttg cag att aag tta tca aca cag      576
 Arg Asp Phe Leu Gln Arg Leu Asp Leu Gln Ile Lys Leu Ser Thr Gln
             180                 185                 190

 gca gcc aag aag cta aaa gaa gag agc aga gat gaa gaa agt ccc tat      624
 Ala Ala Lys Lys Leu Lys Glu Glu Ser Arg Asp Glu Glu Ser Pro Tyr
         195                 200                 205

 gca act tcc ctc tat cac agt tag gtgatttggg ggcataactc taaccaaaat     678
 Ala Thr Ser Leu Tyr His Ser 
     210                 215

 taagatatgt ttggaccata aagaatccaa caactgaaga ttcaaaaaca tcccttctgg    738

 attcctatag tgtccatctt aaaatcataa ctaggtagtt ctacctgctg cagttgcact    798

 gaagtgatta gttccctctg gctttctata attttaagtc tttattatgg catgatggca    858

 aggttgtagc ctaaagctca tcacttttgt aggtggtgtt agtttttaga ctagctttta    918

 taaatactaa ttgacataaa gcatcaaaga ttatttatat atttaggcta aaaataatgt    978

 ttatctcctt atgcaatcct gattatgtga aaatatggtt gctgtttaag tgatgctgaa   1038

 tttgctgtgt gtttataact taagtgctat atatatattt cgatatgtct tacatattct   1098

 ctattaatat aaagaaccaa attttgtctg ctattttgta aaaataaact acaaaagcct   1158

 gaatgagaaa ataaactatg ttttcaaaaa aaaaaa                             1194




      <210> 215
      <211> 5787
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (54)..(4424)

      <400> 215
 tgtggacccc cgagtggctg cggtgctcac cgggcaatat cccctatgct gat   atg      56
                                                              Met
                                                                1

 aaa tat aca gat aag aga aat tta aga gaa act gaa act tcc ctt gtt      104
 Lys Tyr Thr Asp Lys Arg Asn Leu Arg Glu Thr Glu Thr Ser Leu Val
               5                  10                  15

 aga aaa gag ccc tta aca aca att ctt gcg ctt tct gtt cag ggg ctc      152
 Arg Lys Glu Pro Leu Thr Thr Ile Leu Ala Leu Ser Val Gln Gly Leu
          20                  25                  30

 ttt gac aat tat aaa ggc tct ggc ggc agc gtg cat cac aag tgt aac      200
 Phe Asp Asn Tyr Lys Gly Ser Gly Gly Ser Val His His Lys Cys Asn
      35                  40                  45

 agc gcc aaa cac cgc atc atc tcg ccc aag gtg gag cca cgg aca ggg      248
 Ser Ala Lys His Arg Ile Ile Ser Pro Lys Val Glu Pro Arg Thr Gly
  50                  55                  60                  65

 ggg tac ggg agc cac tcg gag gtg cag cac aat gac gtg tcg gag ggc      296
 Gly Tyr Gly Ser His Ser Glu Val Gln His Asn Asp Val Ser Glu Gly
                  70                  75                  80

 aag cac gag cac agc cac agc aag ggc tcc agc cgt gag aag agg aac      344
 Lys His Glu His Ser His Ser Lys Gly Ser Ser Arg Glu Lys Arg Asn
              85                  90                  95

 ggc aag gtg gcc aag ccc gtg ctc ctg cac cag agc agc acc gag gtc      392
 Gly Lys Val Ala Lys Pro Val Leu Leu His Gln Ser Ser Thr Glu Val
         100                 105                 110

 tcc tcc acc aac cag gtg gaa gtc ccc gac acc acc cag agc tcc cct      440
 Ser Ser Thr Asn Gln Val Glu Val Pro Asp Thr Thr Gln Ser Ser Pro
     115                 120                 125

 gtg tcc atc agc agc ggg ctc aac agc gac ccg gac atg gtg gac agc      488
 Val Ser Ile Ser Ser Gly Leu Asn Ser Asp Pro Asp Met Val Asp Ser
 130                 135                 140                 145

 ccg gtg gtc aca ggt gtg tcc ggt atg gcg gtg gcc tct gtg atg ggg      536
 Pro Val Val Thr Gly Val Ser Gly Met Ala Val Ala Ser Val Met Gly
                 150                 155                 160

 agc ttg tcc cag agc gcc acg gtg ttc atg tca gag gtc acc aat gag      584
 Ser Leu Ser Gln Ser Ala Thr Val Phe Met Ser Glu Val Thr Asn Glu
             165                 170                 175

 gcc gtg tac acc atg tcc ccc acc gct ggc ccc aac cac cac ctc ctc      632
 Ala Val Tyr Thr Met Ser Pro Thr Ala Gly Pro Asn His His Leu Leu
         180                 185                 190

 tca cct gac gcc tct cag ggc ctc gtc ctg gcc gtg agc tct gat ggc      680
 Ser Pro Asp Ala Ser Gln Gly Leu Val Leu Ala Val Ser Ser Asp Gly
     195                 200                 205

 cac aag ttc gcc ttt ccc acc acg ggc agc tca gag agc ctg tcc atg      728
 His Lys Phe Ala Phe Pro Thr Thr Gly Ser Ser Glu Ser Leu Ser Met
 210                 215                 220                 225

 ctg ccc acc aac gtg tcc gaa gag ctg gtc ctc tcc acc acc ctc gac      776
 Leu Pro Thr Asn Val Ser Glu Glu Leu Val Leu Ser Thr Thr Leu Asp
                 230                 235                 240

 ggt ggc cgg aag att cca gaa acc acc atg aac ttt gac ccc gac tgt      824
 Gly Gly Arg Lys Ile Pro Glu Thr Thr Met Asn Phe Asp Pro Asp Cys
             245                 250                 255

 ttc ctt aat aac cca aag cag ggc cag acg tac ggg ggt gga ggc ctg      872
 Phe Leu Asn Asn Pro Lys Gln Gly Gln Thr Tyr Gly Gly Gly Gly Leu
         260                 265                 270

 aaa gcc gag atg gtc agc tcc aac atc cgg cac tcg cca ccc ggg gag      920
 Lys Ala Glu Met Val Ser Ser Asn Ile Arg His Ser Pro Pro Gly Glu
     275                 280                 285

 cgg agc ttc agc ttt acc acc gtc ctc acc aag gag atc aag acc gag      968
 Arg Ser Phe Ser Phe Thr Thr Val Leu Thr Lys Glu Ile Lys Thr Glu
 290                 295                 300                 305

 gac acc tcc ttc gag cag cag atg gcc aaa gaa gcg tac tcc tcc tcc     1016
 Asp Thr Ser Phe Glu Gln Gln Met Ala Lys Glu Ala Tyr Ser Ser Ser
                 310                 315                 320

 gcg gcg gct gtg gca gcc agc tcc ctc acc ctg acc gcc ggc tcc agc     1064
 Ala Ala Ala Val Ala Ala Ser Ser Leu Thr Leu Thr Ala Gly Ser Ser
             325                 330                 335

 ctc ctg ccg tcg ggc ggc ggc ctg agt ccc agc acc acc ctg gag cag     1112
 Leu Leu Pro Ser Gly Gly Gly Leu Ser Pro Ser Thr Thr Leu Glu Gln
         340                 345                 350

 atg gac ttc agc gcc atc gac tcc aac aag gac tac acg tcc agc ttc     1160
 Met Asp Phe Ser Ala Ile Asp Ser Asn Lys Asp Tyr Thr Ser Ser Phe
     355                 360                 365

 agc cag acg ggc cac agc ccc cac atc cac cag acc ccc tcc ccg agc     1208
 Ser Gln Thr Gly His Ser Pro His Ile His Gln Thr Pro Ser Pro Ser
 370                 375                 380                 385

 ttc ttc ctg cag gac gcc agc aaa ccc ctc ccc gtc gag cag aac acc     1256
 Phe Phe Leu Gln Asp Ala Ser Lys Pro Leu Pro Val Glu Gln Asn Thr
                 390                 395                 400

 cac agc agc ctg agt gac tct ggg ggc acc ttc gtg atg ccc acg gtg     1304
 His Ser Ser Leu Ser Asp Ser Gly Gly Thr Phe Val Met Pro Thr Val
             405                 410                 415

 aaa acg gag gcc tcg tcc caa acc agc tcc tgc agc ggt cac gtg gag     1352
 Lys Thr Glu Ala Ser Ser Gln Thr Ser Ser Cys Ser Gly His Val Glu
         420                 425                 430

 acg cgg atc gag tcc act tcc tcc ctc cac ctc atg cag ttc cag gcc     1400
 Thr Arg Ile Glu Ser Thr Ser Ser Leu His Leu Met Gln Phe Gln Ala
     435                 440                 445

 aac ttc cag gcc atg acg gca gaa ggg gag gtc acc atg gag acc tcg     1448
 Asn Phe Gln Ala Met Thr Ala Glu Gly Glu Val Thr Met Glu Thr Ser
 450                 455                 460                 465

 cag gcg gcg gaa ggg agc gag gtc ctg ctc aag tct ggg gag ctg cag     1496
 Gln Ala Ala Glu Gly Ser Glu Val Leu Leu Lys Ser Gly Glu Leu Gln
                 470                 475                 480

 gct tgc agc tct gag cac tac ctg cag ccg gag acc aac ggg gta atc     1544
 Ala Cys Ser Ser Glu His Tyr Leu Gln Pro Glu Thr Asn Gly Val Ile
             485                 490                 495

 cga agc gcc ggc ggc gtc ccc atc ctc ccg ggc aac gtg gtg cag gga     1592
 Arg Ser Ala Gly Gly Val Pro Ile Leu Pro Gly Asn Val Val Gln Gly
         500                 505                 510

 ctc tac ccc gtg gcc cag ccc agc ctc ggc aac gcc tcc aac atg gag     1640
 Leu Tyr Pro Val Ala Gln Pro Ser Leu Gly Asn Ala Ser Asn Met Glu
     515                 520                 525

 ctc agc ctg gac cac ttt gac atc tcc ttc agc aac cag ttc tcc gac     1688
 Leu Ser Leu Asp His Phe Asp Ile Ser Phe Ser Asn Gln Phe Ser Asp
 530                 535                 540                 545

 ctg atc aac gac ttc atc tcc gtg gag ggg ggc agc agc acc atc tat     1736
 Leu Ile Asn Asp Phe Ile Ser Val Glu Gly Gly Ser Ser Thr Ile Tyr
                 550                 555                 560

 ggg cac cag ctg gtg tcg ggg gac agc acg gcg ctc tca cag tca gag     1784
 Gly His Gln Leu Val Ser Gly Asp Ser Thr Ala Leu Ser Gln Ser Glu
             565                 570                 575

 gac ggg gcg cgg gcc ccc ttc acc cag gca gag atg tgc ctc ccc tgc     1832
 Asp Gly Ala Arg Ala Pro Phe Thr Gln Ala Glu Met Cys Leu Pro Cys
         580                 585                 590

 tgt agc ccc cag cag ggt agc ctg cag ctg agc agc tcg gag ggc ggg     1880
 Cys Ser Pro Gln Gln Gly Ser Leu Gln Leu Ser Ser Ser Glu Gly Gly
     595                 600                 605

 gcc agc acc atg gcc tac atg cac gtc gcc gag gtg gtc tcg gcc gcc     1928
 Ala Ser Thr Met Ala Tyr Met His Val Ala Glu Val Val Ser Ala Ala
 610                 615                 620                 625

 tcg gcc cag ggc acc cta ggc atg ctg cag cag agc gga cgg gtg ttc     1976
 Ser Ala Gln Gly Thr Leu Gly Met Leu Gln Gln Ser Gly Arg Val Phe
                 630                 635                 640

 atg gtg acc gac tac tcc cca gag tgg tct tac cca gag gga gga gtg     2024
 Met Val Thr Asp Tyr Ser Pro Glu Trp Ser Tyr Pro Glu Gly Gly Val
             645                 650                 655

 aag gtc ctc atc aca ggc ccg tgg caa gaa gcc agc aat aac tac agc     2072
 Lys Val Leu Ile Thr Gly Pro Trp Gln Glu Ala Ser Asn Asn Tyr Ser
         660                 665                 670

 tgc ctg ttt gac cag atc tca gtg cct gca tcc ctg att cag cct ggg     2120
 Cys Leu Phe Asp Gln Ile Ser Val Pro Ala Ser Leu Ile Gln Pro Gly
     675                 680                 685

 gtg ctg cgc tgc tac tgc cca gcc cat gac act ggt ctt gtg acc cta     2168
 Val Leu Arg Cys Tyr Cys Pro Ala His Asp Thr Gly Leu Val Thr Leu
 690                 695                 700                 705

 caa gtt gcc ttc aac aac cag atc atc tcc aac tcg gtg gtg ttt gag     2216
 Gln Val Ala Phe Asn Asn Gln Ile Ile Ser Asn Ser Val Val Phe Glu
                 710                 715                 720

 tac aaa gcc cgg gct ctg ccc acg ctc cct tcc tcc cag cac gac tgg     2264
 Tyr Lys Ala Arg Ala Leu Pro Thr Leu Pro Ser Ser Gln His Asp Trp
             725                 730                 735

 ctg tcg ttg gac gat aac cag ttc agg atg tcc atc ctg gaa cga ctg     2312
 Leu Ser Leu Asp Asp Asn Gln Phe Arg Met Ser Ile Leu Glu Arg Leu
         740                 745                 750

 gag cag atg gag agg agg atg gcc gag atg acg ggg tcc cag cag cac     2360
 Glu Gln Met Glu Arg Arg Met Ala Glu Met Thr Gly Ser Gln Gln His
     755                 760                 765

 aaa cag gcg agc gga ggc ggc agc agt gga ggc ggc agc ggg agc ggg     2408
 Lys Gln Ala Ser Gly Gly Gly Ser Ser Gly Gly Gly Ser Gly Ser Gly
 770                 775                 780                 785

 aat gga ggg agc cag gca cag tgt gct tct ggg act ggg gcc ttg ggg     2456
 Asn Gly Gly Ser Gln Ala Gln Cys Ala Ser Gly Thr Gly Ala Leu Gly
                 790                 795                 800

 agc tgc ttt gag agc cgt gtg gtc gtg gta tgc gag aag atg atg agc     2504
 Ser Cys Phe Glu Ser Arg Val Val Val Val Cys Glu Lys Met Met Ser
             805                 810                 815

 cga gcc tgc tgg gcg aag tcc aag cac ttg atc cac tca aag act ttc     2552
 Arg Ala Cys Trp Ala Lys Ser Lys His Leu Ile His Ser Lys Thr Phe
         820                 825                 830

 cgc gga atg acc cta ctc cac ctg gcc gct gcc cag ggc tat gcc acc     2600
 Arg Gly Met Thr Leu Leu His Leu Ala Ala Ala Gln Gly Tyr Ala Thr
     835                 840                 845

 cta atc cag acc ctc atc aaa tgg cgt aca aag cac gcg gat agc att     2648
 Leu Ile Gln Thr Leu Ile Lys Trp Arg Thr Lys His Ala Asp Ser Ile
 850                 855                 860                 865

 gac ctg gaa ctg gaa gtt gac ccc ttg aat gtg gac cac ttc tcc tgt     2696
 Asp Leu Glu Leu Glu Val Asp Pro Leu Asn Val Asp His Phe Ser Cys
                 870                 875                 880

 act cct ctg atg tgg gcg tgt gcc cta ggg cac ttg gaa gct gcc gtc     2744
 Thr Pro Leu Met Trp Ala Cys Ala Leu Gly His Leu Glu Ala Ala Val
             885                 890                 895

 gtg ctg tac aag tgg gac cgt cgg gcc atc tcg att ccc gac tct cta     2792
 Val Leu Tyr Lys Trp Asp Arg Arg Ala Ile Ser Ile Pro Asp Ser Leu
         900                 905                 910

 gga agg ctg cct ttg gga att gcc agg tca cgg ggt cat gtg aaa tta     2840
 Gly Arg Leu Pro Leu Gly Ile Ala Arg Ser Arg Gly His Val Lys Leu
     915                 920                 925

 gca gag tgt ctg gag cac ctg cag aga gat gag cag gct cag ctg gga     2888
 Ala Glu Cys Leu Glu His Leu Gln Arg Asp Glu Gln Ala Gln Leu Gly
 930                 935                 940                 945

 cag aac ccc aga atc cac tgt cct gca agc gaa gag ccc agc aca gag     2936
 Gln Asn Pro Arg Ile His Cys Pro Ala Ser Glu Glu Pro Ser Thr Glu
                 950                 955                 960

 agc tgg atg gcc cag tgg cac agc gaa gcc atc agc tct cca gaa ata     2984
 Ser Trp Met Ala Gln Trp His Ser Glu Ala Ile Ser Ser Pro Glu Ile
             965                 970                 975

 ccc aag gga gtc act gtt att gca agc acc aac cca gag ctg aga aga     3032
 Pro Lys Gly Val Thr Val Ile Ala Ser Thr Asn Pro Glu Leu Arg Arg
         980                 985                 990

 cct cgt tct gaa ccc tct aat tac tac agc agt gag agc cac aaa gat     3080
 Pro Arg Ser Glu Pro Ser Asn Tyr Tyr Ser Ser Glu Ser His Lys Asp
     995                1000                1005

 tat ccg gct ccc aaa aag cat aaa ttg aac cct gag tac ttc cag aca     3128
 Tyr Pro Ala Pro Lys Lys His Lys Leu Asn Pro Glu Tyr Phe Gln Thr
1010                1015                1020                1025

 agg cag gag aag ctg ctt ccc act gca ctg agt ctg gaa gag cca aat     3176
 Arg Gln Glu Lys Leu Leu Pro Thr Ala Leu Ser Leu Glu Glu Pro Asn
                1030                1035                1040

 atc agg aag caa agc cct agt tct aag cag tct gtc ccc gag aca ctc     3224
 Ile Arg Lys Gln Ser Pro Ser Ser Lys Gln Ser Val Pro Glu Thr Leu
            1045                1050                1055

 agc ccc agt gaa gga gtg agg gac ttc agc cgg gaa ctc tcc cct ccc     3272
 Ser Pro Ser Glu Gly Val Arg Asp Phe Ser Arg Glu Leu Ser Pro Pro
        1060                1065                1070

 act cca gag act gca gca ttt caa gcc tct gga tct cag cct gta gga     3320
 Thr Pro Glu Thr Ala Ala Phe Gln Ala Ser Gly Ser Gln Pro Val Gly
    1075                1080                1085

 aag tgg aat tcc aaa gat ctt tac att ggt gtg tct aca gta cag gtg     3368
 Lys Trp Asn Ser Lys Asp Leu Tyr Ile Gly Val Ser Thr Val Gln Val
1090                1095                1100                1105

 act gga aat ccg aag ggg acc agt gta gga aag gag gca gca cct tca     3416
 Thr Gly Asn Pro Lys Gly Thr Ser Val Gly Lys Glu Ala Ala Pro Ser
                1110                1115                1120

 cag gtg cgt cca cgg gaa cca atg agt gtc ctg atg atg gct aac aga     3464
 Gln Val Arg Pro Arg Glu Pro Met Ser Val Leu Met Met Ala Asn Arg
            1125                1130                1135

 gag gtg gtg aat aca gag ctg ggg tcc tac cgt gat agt gca gaa aat     3512
 Glu Val Val Asn Thr Glu Leu Gly Ser Tyr Arg Asp Ser Ala Glu Asn
        1140                1145                1150

 gaa gaa tgc ggc cag ccc atg gat gac ata cag gta aaa agc agg gac     3560
 Glu Glu Cys Gly Gln Pro Met Asp Asp Ile Gln Val Lys Ser Arg Asp
    1155                1160                1165

 agg gtg aac atg atg acc ttg gca gaa cac att att gaa gcc aca cct     3608
 Arg Val Asn Met Met Thr Leu Ala Glu His Ile Ile Glu Ala Thr Pro
1170                1175                1180                1185

 gac cga atc aag cag gag aat ttt gtg ccc atg gag tcc tca gga ttg     3656
 Asp Arg Ile Lys Gln Glu Asn Phe Val Pro Met Glu Ser Ser Gly Leu
                1190                1195                1200

 gaa aga aca gac cct gcc acc att agc agt aca atg agc tgg ctg gcc     3704
 Glu Arg Thr Asp Pro Ala Thr Ile Ser Ser Thr Met Ser Trp Leu Ala
            1205                1210                1215

 agt tat cta gcg gat gct gac tgc ctt ccc agt gct gcc cag atc cga     3752
 Ser Tyr Leu Ala Asp Ala Asp Cys Leu Pro Ser Ala Ala Gln Ile Arg
        1220                1225                1230

 agt gca tat aac gag cct cta acc cct tct tct aat acc agc ttg agc     3800
 Ser Ala Tyr Asn Glu Pro Leu Thr Pro Ser Ser Asn Thr Ser Leu Ser
    1235                1240                1245

 cct gtt ggc tct ccc gtc agt gaa atc gct ttc gag aaa cct aac ctt     3848
 Pro Val Gly Ser Pro Val Ser Glu Ile Ala Phe Glu Lys Pro Asn Leu
1250                1255                1260                1265

 ccc tcc gcc gcg gat tgg tca gaa ttc ctg agt gca tct acc agt gag     3896
 Pro Ser Ala Ala Asp Trp Ser Glu Phe Leu Ser Ala Ser Thr Ser Glu
                1270                1275                1280

 aag gta gag aat gag ttt gct cag ctc act ctg tct gat cat gaa cag     3944
 Lys Val Glu Asn Glu Phe Ala Gln Leu Thr Leu Ser Asp His Glu Gln
            1285                1290                1295

 aga gaa ctc tat gag gct gcc agg ctt gtc cag aca gct ttc cgg aaa     3992
 Arg Glu Leu Tyr Glu Ala Ala Arg Leu Val Gln Thr Ala Phe Arg Lys
        1300                1305                1310

 tac aag ggc cga ccc ttg cgg gaa cag caa gaa gta gct gct gct gtt     4040
 Tyr Lys Gly Arg Pro Leu Arg Glu Gln Gln Glu Val Ala Ala Ala Val
    1315                1320                1325

 att cag cgt tgt tac aga aaa tat aaa cag ctg aca tgg ata gcc ttg     4088
 Ile Gln Arg Cys Tyr Arg Lys Tyr Lys Gln Leu Thr Trp Ile Ala Leu
1330                1335                1340                1345

 aag tac gca ctt tat aaa aag atg aca cag gct gcc atc ctt atc cag     4136
 Lys Tyr Ala Leu Tyr Lys Lys Met Thr Gln Ala Ala Ile Leu Ile Gln
                1350                1355                1360

 agc aaa ttc cga agt tac tat gaa caa aaa aaa ttc cag cag agc cga     4184
 Ser Lys Phe Arg Ser Tyr Tyr Glu Gln Lys Lys Phe Gln Gln Ser Arg
            1365                1370                1375

 cgg gct gct gtg ctc atc caa aag tac tac cga agt tat aag aaa tgt     4232
 Arg Ala Ala Val Leu Ile Gln Lys Tyr Tyr Arg Ser Tyr Lys Lys Cys
        1380                1385                1390

 ggc aaa aga cgg cag gct cgc cgg acg gct gtg att gta caa cag aaa     4280
 Gly Lys Arg Arg Gln Ala Arg Arg Thr Ala Val Ile Val Gln Gln Lys
    1395                1400                1405

 ctc agg agc agt ttg cta acc aaa aag cag gat caa gct gct cga aaa     4328
 Leu Arg Ser Ser Leu Leu Thr Lys Lys Gln Asp Gln Ala Ala Arg Lys
1410                1415                1420                1425

 ata atg agg ttt ctt cgc cgc tgt cgc cac agc ccc ctg gtg gac cat     4376
 Ile Met Arg Phe Leu Arg Arg Cys Arg His Ser Pro Leu Val Asp His
                1430                1435                1440

 agg ctg tac aaa agg agt gaa aga att gaa aaa ggc caa gga act tga     4424
 Arg Leu Tyr Lys Arg Ser Glu Arg Ile Glu Lys Gly Gln Gly Thr 
            1445                1450                1455

 agacatacag cagcatccct tagcaatgtg acattgcttt tcagactgtt ttcatttctg   4484

 tttttagcag agacatgcaa caacaacaca cacgcacaca cgcacacaca cacacgtaca   4544

 cacacataca aaatccctct gcagttttgg ggagatcagc tgcaggattt taacaggaat   4604

 gttttggtca ttgcatttgc actttcatgg acaactttta atttgatcag caagacatct   4664

 tggaactcaa tcttctgttg gatcacggga aatcaagaca cccaggagga attgaaagag   4724

 gcttcctctt ctcaggaaga agccatttcc ttctcatata gggctgtatt caaacatcgt   4784

 gtggaactgt acaaatattt ataccaaaaa tatagataag aaaaggtggg gctatactag   4844

 caacaaaaaa agaatgctgt tcctgcacct gccggttatt tccaagaagc tgaatctttg   4904

 ggactgattc tcagtggagg gcttagatca tacaaaaatc tttattgggt ccgtgtgttc   4964

 tcatttcctt cactgtttat ttttgtttgt ttgtttgttt gttttaatct ctacagcaca   5024

 tttaatgcaa cttttgaaat ctgcaggttt ttaatgtctt gtggaaattt gcagaggggc   5084

 aggtgtgtgg taaacgggta atgcatggga aataatgaga agcagctcac agagtttaaa   5144

 ctattttctt gtccccacca ccttccaaga acctgcgagg gtagtaatca tcttgtcccc   5204

 tttttcatgt tcagcacttt aatttttttg ccttactttc atgtgcaatg agaattactt   5264

 aagaattggt aacgcatgta gcctttttta gtaaccttgg aagctgtaga aattctaagg   5324

 aatcatgaac cttgcctgga catttgccac ctaaacgatc agtgtggtgc tgcgttctgg   5384

 ccagtaaatt ccatgttttt ggctatatct catccaaact gagcagtttc tgtgtatata   5444

 tagaaggtag aaatgaaaag tgagaaaata tttgaaaggg attatattaa ttgctaaata   5504

 ttttattcac aaaggtcaat aacatggcaa gataaaatta tttgtatagt tttgtctgaa   5564

 tgagcgagaa aaatgtggat gtactgtttg tatatattgt atatattaaa acagagatat   5624

 gtgcatgaaa tcaagaaaaa agaaatgaac aaaagcaaag cattagtggc tatggtctgt   5684

 aaaatgaaac aaaaaaactt tatttcacta taagagtact ttattttaaa tgttctttag   5744

 gagaacattt tgctaaagca tgactaaact gcaaaaaaaa aaa                     5787




      <210> 216
      <211> 3583
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3009)

      <400> 216
  atg agg aaa tac tct aga ggc tgg tgg agc cac aag gaa tct ggg ccc      48
  Met Arg Lys Tyr Ser Arg Gly Trp Trp Ser His Lys Glu Ser Gly Pro
    1               5                  10                  15

 ctg gat ggt gga gaa gcg cca tca cct gtc tct gac tat cct cct atg       96
 Leu Asp Gly Gly Glu Ala Pro Ser Pro Val Ser Asp Tyr Pro Pro Met
              20                  25                  30

 ggt gga cca tta gcc aac agt gtt cac acc tgt ctc att tac ctg ctg      144
 Gly Gly Pro Leu Ala Asn Ser Val His Thr Cys Leu Ile Tyr Leu Leu
          35                  40                  45

 tat tct ggg gtt cct ctg tta cag cag ctt agc cta tac ccg act aaa      192
 Tyr Ser Gly Val Pro Leu Leu Gln Gln Leu Ser Leu Tyr Pro Thr Lys
      50                  55                  60

 tac agt gat tta gca gag gaa agg aaa agt ggt gtg gga aca aat att      240
 Tyr Ser Asp Leu Ala Glu Glu Arg Lys Ser Gly Val Gly Thr Asn Ile
  65                  70                  75                  80

 cca tcc ctg tgg aat ccg tca gat tca tct gag gaa gtg gtt ttt agc      288
 Pro Ser Leu Trp Asn Pro Ser Asp Ser Ser Glu Glu Val Val Phe Ser
                  85                  90                  95

 caa gtc ttg aaa gta tat aga ttg agc gac ttt acg atg gca aca agt      336
 Gln Val Leu Lys Val Tyr Arg Leu Ser Asp Phe Thr Met Ala Thr Ser
             100                 105                 110

 atg gcg gct gct agt ggt aga ttt gaa agt gcg aag agt atc gaa gag      384
 Met Ala Ala Ala Ser Gly Arg Phe Glu Ser Ala Lys Ser Ile Glu Glu
         115                 120                 125

 cgg aaa gaa cag acc cgg aat gcc agg gcc gag gtg ttg cgc cag gct      432
 Arg Lys Glu Gln Thr Arg Asn Ala Arg Ala Glu Val Leu Arg Gln Ala
     130                 135                 140

 aaa gcc aat ttt gaa aaa gaa gaa agg cgt aaa gaa ctt aag cga ctt      480
 Lys Ala Asn Phe Glu Lys Glu Glu Arg Arg Lys Glu Leu Lys Arg Leu
 145                 150                 155                 160

 cgg ggt gag gat aca tgg atg cta cct gat gtg aat gag aga att gaa      528
 Arg Gly Glu Asp Thr Trp Met Leu Pro Asp Val Asn Glu Arg Ile Glu
                 165                 170                 175

 cag ttc tca cag gaa cac tct gtg aag aaa aag aag aaa aaa gac aag      576
 Gln Phe Ser Gln Glu His Ser Val Lys Lys Lys Lys Lys Lys Asp Lys
             180                 185                 190

 cat tca aaa aaa gca aag aaa gaa aag aaa aaa aag agc aag aaa cag      624
 His Ser Lys Lys Ala Lys Lys Glu Lys Lys Lys Lys Ser Lys Lys Gln
         195                 200                 205

 aaa tat gaa aaa aac aat gag tca tct gat agc tca tca agc tct gaa      672
 Lys Tyr Glu Lys Asn Asn Glu Ser Ser Asp Ser Ser Ser Ser Ser Glu
     210                 215                 220

 gat gag tgg gtt gag gct gtt cca tcc cag act cct gac aag gaa aaa      720
 Asp Glu Trp Val Glu Ala Val Pro Ser Gln Thr Pro Asp Lys Glu Lys
 225                 230                 235                 240

 gcc tgg aaa gtg aaa gat gaa aag tca gga aaa gat gac acc caa att      768
 Ala Trp Lys Val Lys Asp Glu Lys Ser Gly Lys Asp Asp Thr Gln Ile
                 245                 250                 255

 atc aag agg gat gag tgg atg act gtt gat ttt atg tct gtt aaa act      816
 Ile Lys Arg Asp Glu Trp Met Thr Val Asp Phe Met Ser Val Lys Thr
             260                 265                 270

 gtg tca tca tca tca ctc aaa gct gaa aag gaa act atg agg aaa ata      864
 Val Ser Ser Ser Ser Leu Lys Ala Glu Lys Glu Thr Met Arg Lys Ile
         275                 280                 285

 gag caa gag aaa aac caa gcg ctt gaa cag tcc aaa ctg atg gaa aga      912
 Glu Gln Glu Lys Asn Gln Ala Leu Glu Gln Ser Lys Leu Met Glu Arg
     290                 295                 300

 gaa ttg aat ccg tac tgg aag gat ggt ggg aca ggt ctt cca cct gaa      960
 Glu Leu Asn Pro Tyr Trp Lys Asp Gly Gly Thr Gly Leu Pro Pro Glu
 305                 310                 315                 320

 gac tgt agt gtg tca tcg att act aaa gtt tca gtg gta gaa gat ggt     1008
 Asp Cys Ser Val Ser Ser Ile Thr Lys Val Ser Val Val Glu Asp Gly
                 325                 330                 335

 gga tta agc tgg cta agg aaa tct tat cta aga atg aag gaa caa gct     1056
 Gly Leu Ser Trp Leu Arg Lys Ser Tyr Leu Arg Met Lys Glu Gln Ala
             340                 345                 350

 gag aaa caa agt aga aac ttt gag gac att gta gcc gaa aga tat ggg     1104
 Glu Lys Gln Ser Arg Asn Phe Glu Asp Ile Val Ala Glu Arg Tyr Gly
         355                 360                 365

 tca atg gaa ata ttt cag tca aaa tta gaa gat gct gaa aaa gct gca     1152
 Ser Met Glu Ile Phe Gln Ser Lys Leu Glu Asp Ala Glu Lys Ala Ala
     370                 375                 380

 tcc acg aaa gaa gat tat aga cgg gaa cgg tgg agg aaa ccc aca tat     1200
 Ser Thr Lys Glu Asp Tyr Arg Arg Glu Arg Trp Arg Lys Pro Thr Tyr
 385                 390                 395                 400

 tca gat aaa gca caa aat tgt caa gaa agt aga gaa tca gac tta gta     1248
 Ser Asp Lys Ala Gln Asn Cys Gln Glu Ser Arg Glu Ser Asp Leu Val
                 405                 410                 415

 aaa tat ggt aac agt tca agg gat aga tat gct aca aca gat act gca     1296
 Lys Tyr Gly Asn Ser Ser Arg Asp Arg Tyr Ala Thr Thr Asp Thr Ala
             420                 425                 430

 aaa aat agc aat aat gaa aaa ttt att ggt gat gaa aaa gat aag aga     1344
 Lys Asn Ser Asn Asn Glu Lys Phe Ile Gly Asp Glu Lys Asp Lys Arg
         435                 440                 445

 cct ggg tct tta gaa acg tgt aga aga gaa tct aac cca agg caa aat     1392
 Pro Gly Ser Leu Glu Thr Cys Arg Arg Glu Ser Asn Pro Arg Gln Asn
     450                 455                 460

 caa gag ttt tct ttt ggc aat ttg aga gct aaa ttc ttg aga ccc tct     1440
 Gln Glu Phe Ser Phe Gly Asn Leu Arg Ala Lys Phe Leu Arg Pro Ser
 465                 470                 475                 480

 gat gat gaa gaa ctg tca ttt cac agc aag ggc aga aaa ttt gaa cca     1488
 Asp Asp Glu Glu Leu Ser Phe His Ser Lys Gly Arg Lys Phe Glu Pro
                 485                 490                 495

 ctt agt tca tct tca gca ttg gta gct cag ggc tct ttg tgt agt ggt     1536
 Leu Ser Ser Ser Ser Ala Leu Val Ala Gln Gly Ser Leu Cys Ser Gly
             500                 505                 510

 ttt aga aaa ccc acc aag aac agt gaa gaa aga tta aca tca tgg agt     1584
 Phe Arg Lys Pro Thr Lys Asn Ser Glu Glu Arg Leu Thr Ser Trp Ser
         515                 520                 525

 cgc tct gat ggg aga gga gac aag aaa cat tca aat caa aag cca tcg     1632
 Arg Ser Asp Gly Arg Gly Asp Lys Lys His Ser Asn Gln Lys Pro Ser
     530                 535                 540

 gaa acc agt act gat gaa cac caa cat gtt cca gaa gac cca aga gaa     1680
 Glu Thr Ser Thr Asp Glu His Gln His Val Pro Glu Asp Pro Arg Glu
 545                 550                 555                 560

 aaa tca caa gat gaa gtc ttg aga gat gac cct cca aaa aaa gaa cat     1728
 Lys Ser Gln Asp Glu Val Leu Arg Asp Asp Pro Pro Lys Lys Glu His
                 565                 570                 575

 cta cgg gat aca aag tct aca ttt gct ggc agt cca gag cgt gag tcc     1776
 Leu Arg Asp Thr Lys Ser Thr Phe Ala Gly Ser Pro Glu Arg Glu Ser
             580                 585                 590

 att cac atc ctg agt gtt gat gag aag aac aag ttg gga gcc aag att     1824
 Ile His Ile Leu Ser Val Asp Glu Lys Asn Lys Leu Gly Ala Lys Ile
         595                 600                 605

 atc aaa gca gag atg atg ggg aat atg gaa tta gct gaa caa ctt aaa     1872
 Ile Lys Ala Glu Met Met Gly Asn Met Glu Leu Ala Glu Gln Leu Lys
     610                 615                 620

 gtt caa ctt gaa aag gca aat aaa ttc aaa gaa act ata aca cag ata     1920
 Val Gln Leu Glu Lys Ala Asn Lys Phe Lys Glu Thr Ile Thr Gln Ile
 625                 630                 635                 640

 cca aaa aaa tct ggg gta gag aat gaa gac cag caa gaa gta atc ctt     1968
 Pro Lys Lys Ser Gly Val Glu Asn Glu Asp Gln Gln Glu Val Ile Leu
                 645                 650                 655

 gtc aga aca gat cag tct gga aga gta tgg cct gtg aac aca ccc gga     2016
 Val Arg Thr Asp Gln Ser Gly Arg Val Trp Pro Val Asn Thr Pro Gly
             660                 665                 670

 aaa tct ctg gaa tca caa gga gga aga aga aag aga cag atg gtt tca     2064
 Lys Ser Leu Glu Ser Gln Gly Gly Arg Arg Lys Arg Gln Met Val Ser
         675                 680                 685

 acc cat gag gaa aga gaa agg gtc aga tac ttt cat gat gat gat aat     2112
 Thr His Glu Glu Arg Glu Arg Val Arg Tyr Phe His Asp Asp Asp Asn
     690                 695                 700

 cta agc cta aat gat tta gtc aaa aat gaa aag atg gga aca gca gaa     2160
 Leu Ser Leu Asn Asp Leu Val Lys Asn Glu Lys Met Gly Thr Ala Glu
 705                 710                 715                 720

 aat caa aac aag ctc ttt atg aga atg gca tct aag ttt atg gga aaa     2208
 Asn Gln Asn Lys Leu Phe Met Arg Met Ala Ser Lys Phe Met Gly Lys
                 725                 730                 735

 aca gat gga gac tat tac acc ctg gat gac atg ttt gtc tcc aaa gca     2256
 Thr Asp Gly Asp Tyr Tyr Thr Leu Asp Asp Met Phe Val Ser Lys Ala
             740                 745                 750

 gct gag aga gaa cgt ctt ggt gaa gag gaa gag aac caa agg aaa aaa     2304
 Ala Glu Arg Glu Arg Leu Gly Glu Glu Glu Glu Asn Gln Arg Lys Lys
         755                 760                 765

 gct att gct gag cat cgg agt ctt gct gca caa atg gaa aaa tgt ctg     2352
 Ala Ile Ala Glu His Arg Ser Leu Ala Ala Gln Met Glu Lys Cys Leu
     770                 775                 780

 tat tgt ttt gac agc tct caa ttt ccc aag cat ctt att gtt gca ata     2400
 Tyr Cys Phe Asp Ser Ser Gln Phe Pro Lys His Leu Ile Val Ala Ile
 785                 790                 795                 800

 ggt gtt aag gtt tat tta tgt tta ccc aac gta cgg tct ctt act gag     2448
 Gly Val Lys Val Tyr Leu Cys Leu Pro Asn Val Arg Ser Leu Thr Glu
                 805                 810                 815

 ggg cac tgc ctg ata gtc cct ttg cag cac cat aga gca gct act ttg     2496
 Gly His Cys Leu Ile Val Pro Leu Gln His His Arg Ala Ala Thr Leu
             820                 825                 830

 ttg gat gaa gac atc tgg gag gag atc cag atg ttc aga aaa tca ttg     2544
 Leu Asp Glu Asp Ile Trp Glu Glu Ile Gln Met Phe Arg Lys Ser Leu
         835                 840                 845

 gta aag atg ttt gaa gat aaa gga tta gac tgc att ttt ttg gaa act     2592
 Val Lys Met Phe Glu Asp Lys Gly Leu Asp Cys Ile Phe Leu Glu Thr
     850                 855                 860

 aat atg agc atg aag aaa cag tat cac atg gtt tat gaa tgt att cct     2640
 Asn Met Ser Met Lys Lys Gln Tyr His Met Val Tyr Glu Cys Ile Pro
 865                 870                 875                 880

 ctt ccc aag gaa gtg ggt gac atg gct ccc atc tat ttt aag aaa gcc     2688
 Leu Pro Lys Glu Val Gly Asp Met Ala Pro Ile Tyr Phe Lys Lys Ala
                 885                 890                 895

 ata atg gaa tct gat gaa gag tgg tcc atg aac aag aag ttg ata gat     2736
 Ile Met Glu Ser Asp Glu Glu Trp Ser Met Asn Lys Lys Leu Ile Asp
             900                 905                 910

 ctc tct tca aaa gat atc aga aag tct gta ccc aga ggg tta cct tac     2784
 Leu Ser Ser Lys Asp Ile Arg Lys Ser Val Pro Arg Gly Leu Pro Tyr
         915                 920                 925

 ttc tct gtg gat ttt ggc ctt cac gga ggg ttt gcc cat gtc att gaa     2832
 Phe Ser Val Asp Phe Gly Leu His Gly Gly Phe Ala His Val Ile Glu
     930                 935                 940

 gat cag cac aaa ttc cct cat tac ttt gga aag gaa atc ata ggt ggg     2880
 Asp Gln His Lys Phe Pro His Tyr Phe Gly Lys Glu Ile Ile Gly Gly
 945                 950                 955                 960

 atg ctg gat ata gaa cca aga ctt tgg agg aaa ggc atc cga gaa agc     2928
 Met Leu Asp Ile Glu Pro Arg Leu Trp Arg Lys Gly Ile Arg Glu Ser
                 965                 970                 975

 ttt gag gat cag agg aaa aaa gca ctg cag ttt gct cag tgg tgg aaa     2976
 Phe Glu Asp Gln Arg Lys Lys Ala Leu Gln Phe Ala Gln Trp Trp Lys
             980                 985                 990

 cca tat gac ttc acc aaa agt aaa aac tat tga ggtgtacc ttccatttta     3027
 Pro Tyr Asp Phe Thr Lys Ser Lys Asn Tyr 
         995                1000

 aaatttttct tgagatcccg ttcagtttta tttccattgc atctaatgaa gcaactgacc   3087

 ctcaggtcac aggcagagag aatcacagca gcagactgct ctgggtcagt gacaactgta   3147

 catcaggaga ttgtgttgtt ttcttcttca cctgctccta tctatggact tcattttagt   3207

 caccatggag taaaaacata tattcgatga tctgctcaca ttcctgctct ctacctactt   3267

 cttggtattc cgaattgttc agttaattta gagaaggcct tttctgaagg gatatctaga   3327

 aagcatagga aatccttggt tcagagggaa gtgggtctgc ttcatggttg ttaagtctac   3387

 tgtctggctt cttttgcatt tttaaaaata agacgattta attttaattt cataggattt   3447

 tatagaaaag ctcttaattt tctactagca gtatatagta tcacttctat tctttttgtt   3507

 aaaggaaaag gaaatgtccc caaagtatta aagaattaaa tgatactgaa aatttgtatg   3567

 attcaaaaaa aaaaaa                                                   3583




      <210> 217
      <211> 2339
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (210)..(2003)

      <400> 217
 ttccaaggcc cggcagcctc agtccactgc tgggcctgga acacggagca gtggctgccc     60

 tgcgaggagg tcctagagca gctccagcag gatggcggct ccagcgtctc taaggcctgc    120

 agggggtcca gccccatggg gggcgcccta ggcctccgac agctccccat ctgtgctcct    180

 gcctgccggc catcctcagg ccactcgcc  atg ggc ggc tgc ttc tcc aaa ccc     233
                                  Met Gly Gly Cys Phe Ser Lys Pro
                                    1               5

 aaa cca gtg gag ctc aag atc gag gtg gtg ctg cct gag aag gag cga      281
 Lys Pro Val Glu Leu Lys Ile Glu Val Val Leu Pro Glu Lys Glu Arg
      10                  15                  20

 ggc aag gag gag ctg tcg gcc agt ggg aag ggc agc ccc cgg gcc tac      329
 Gly Lys Glu Glu Leu Ser Ala Ser Gly Lys Gly Ser Pro Arg Ala Tyr
  25                  30                  35                  40

 cag ggc aat ggc acg gcc cgc cac ttc cac acg gag gag cgc ctg tcc      377
 Gln Gly Asn Gly Thr Ala Arg His Phe His Thr Glu Glu Arg Leu Ser
                  45                  50                  55

 acc cct cac ccc tac ccc agc cct cag gat tgc gtg gag gct gct gtc      425
 Thr Pro His Pro Tyr Pro Ser Pro Gln Asp Cys Val Glu Ala Ala Val
              60                  65                  70

 tgc cac gtc aag gac ctc gag aat ggc cag atg cgg gaa gtg gag ctg      473
 Cys His Val Lys Asp Leu Glu Asn Gly Gln Met Arg Glu Val Glu Leu
          75                  80                  85

 ggc tgg ggg aag gtg ttg ctg gtg aag gac aat ggg gag ttc cac gcc      521
 Gly Trp Gly Lys Val Leu Leu Val Lys Asp Asn Gly Glu Phe His Ala
      90                  95                 100

 ctg ggc cat aag tgt ccg cac tac ggc gca ccc ctg gtg aaa ggc gtt      569
 Leu Gly His Lys Cys Pro His Tyr Gly Ala Pro Leu Val Lys Gly Val
 105                 110                 115                 120

 ctg tcc cgt ggt cgg gtg cgc tgc ccc tgg cac ggc gcc tgc ttc aac      617
 Leu Ser Arg Gly Arg Val Arg Cys Pro Trp His Gly Ala Cys Phe Asn
                 125                 130                 135

 atc agc act ggg gac ctg gag gac ttc cct ggc ctg gac agt cta cac      665
 Ile Ser Thr Gly Asp Leu Glu Asp Phe Pro Gly Leu Asp Ser Leu His
             140                 145                 150

 aag ttc cag gtg aag att gag aag gag aag gtg tac gtc cgg gcc agc      713
 Lys Phe Gln Val Lys Ile Glu Lys Glu Lys Val Tyr Val Arg Ala Ser
         155                 160                 165

 aag cag gcc cta cag ctg cag cga agg acc aag gtg atg gcc aag tgt      761
 Lys Gln Ala Leu Gln Leu Gln Arg Arg Thr Lys Val Met Ala Lys Cys
     170                 175                 180

 atc tct cca agt gct ggg tac agc agt agc acc aat gtg ctc att gtg      809
 Ile Ser Pro Ser Ala Gly Tyr Ser Ser Ser Thr Asn Val Leu Ile Val
 185                 190                 195                 200

 ggt gca gag aca ctg cgg cag gag ggc ttc tcc gac cgg atc gtc ctg      857
 Gly Ala Glu Thr Leu Arg Gln Glu Gly Phe Ser Asp Arg Ile Val Leu
                 205                 210                 215

 tgc acg cta gac cgg cac ctt ccc tac gac cgt ccc aag ctc agc aag      905
 Cys Thr Leu Asp Arg His Leu Pro Tyr Asp Arg Pro Lys Leu Ser Lys
             220                 225                 230

 tcc ctg gac aca cag cct gag cag ctg gcc ctg agg ccc aag gag ttt      953
 Ser Leu Asp Thr Gln Pro Glu Gln Leu Ala Leu Arg Pro Lys Glu Phe
         235                 240                 245

 ttc cga gcc tat ggc atc gag gtg ctc acc gag gct cag gtg gtc aca     1001
 Phe Arg Ala Tyr Gly Ile Glu Val Leu Thr Glu Ala Gln Val Val Thr
     250                 255                 260

 gtg gac gtg aga act aag aag gtc gtg ttc aag gat ggc ttc aag ctg     1049
 Val Asp Val Arg Thr Lys Lys Val Val Phe Lys Asp Gly Phe Lys Leu
 265                 270                 275                 280

 gag tac agc aag ctg ctg ctg gca cca ggg agc agc ccc aag act ctg     1097
 Glu Tyr Ser Lys Leu Leu Leu Ala Pro Gly Ser Ser Pro Lys Thr Leu
                 285                 290                 295

 agc tgc aaa ggc aaa gaa gtg gag aac gtg ttc act atc cgg acg cca     1145
 Ser Cys Lys Gly Lys Glu Val Glu Asn Val Phe Thr Ile Arg Thr Pro
             300                 305                 310

 gag gat gcc aat cgc gtg gtg agg ctg gct cga ggc cgc aac gtg gtc     1193
 Glu Asp Ala Asn Arg Val Val Arg Leu Ala Arg Gly Arg Asn Val Val
         315                 320                 325

 gtc gtg gga gcc ggc ttc ctg ggg atg gag gtg gcc gct tac ctg acg     1241
 Val Val Gly Ala Gly Phe Leu Gly Met Glu Val Ala Ala Tyr Leu Thr
     330                 335                 340

 gag aag gcc cac tct gtg tct gtg gtg gag ctg gag gag acg ccc ttc     1289
 Glu Lys Ala His Ser Val Ser Val Val Glu Leu Glu Glu Thr Pro Phe
 345                 350                 355                 360

 agg agg ttc ctg ggg gag cgc gtg ggt cgt gcc ctc atg aag atg ttt     1337
 Arg Arg Phe Leu Gly Glu Arg Val Gly Arg Ala Leu Met Lys Met Phe
                 365                 370                 375

 gag aac aac cgg gtg aag ttc tac atg cag acg gag gtg tct gag ctg     1385
 Glu Asn Asn Arg Val Lys Phe Tyr Met Gln Thr Glu Val Ser Glu Leu
             380                 385                 390

 cgg ggc cag gag gga aag ctg aag gag gtt gtg ctg aag agc agc aag     1433
 Arg Gly Gln Glu Gly Lys Leu Lys Glu Val Val Leu Lys Ser Ser Lys
         395                 400                 405

 gtc gtg cgg gct gac gtc tgc gtg gtg ggc att ggt gca gtg ccc gcc     1481
 Val Val Arg Ala Asp Val Cys Val Val Gly Ile Gly Ala Val Pro Ala
     410                 415                 420

 aca ggc ttc ctg agg caa agc ggc atc ggt ttg gat tcc cga ggc ttc     1529
 Thr Gly Phe Leu Arg Gln Ser Gly Ile Gly Leu Asp Ser Arg Gly Phe
 425                 430                 435                 440

 atc cct gtc aac aag atg atg cag acc aat gtc cca ggc gtg ttt gca     1577
 Ile Pro Val Asn Lys Met Met Gln Thr Asn Val Pro Gly Val Phe Ala
                 445                 450                 455

 gct ggc gat gct gtc acc ttc ccc ctt gcc tgg agg aac aac cgc aaa     1625
 Ala Gly Asp Ala Val Thr Phe Pro Leu Ala Trp Arg Asn Asn Arg Lys
             460                 465                 470

 gtg aac att cca cat tgg cag atg gct cat gct cag ggg cgc gtg gca     1673
 Val Asn Ile Pro His Trp Gln Met Ala His Ala Gln Gly Arg Val Ala
         475                 480                 485

 gcc cag aac atg ttg gcg cag gag gcg gag atg agc act gtg ccc tac     1721
 Ala Gln Asn Met Leu Ala Gln Glu Ala Glu Met Ser Thr Val Pro Tyr
     490                 495                 500

 ctc tgg acc gcc atg ttt ggc aag agc ctg cgc tac gcg ggc tac gga     1769
 Leu Trp Thr Ala Met Phe Gly Lys Ser Leu Arg Tyr Ala Gly Tyr Gly
 505                 510                 515                 520

 gaa ggc ttc gac gac gtc atc atc cag ggg gat ctg gag gag ctg aag     1817
 Glu Gly Phe Asp Asp Val Ile Ile Gln Gly Asp Leu Glu Glu Leu Lys
                 525                 530                 535

 ttt gtg gct ttt tac act aaa ggc gac gag gtg atc gcc gtg gcc agc     1865
 Phe Val Ala Phe Tyr Thr Lys Gly Asp Glu Val Ile Ala Val Ala Ser
             540                 545                 550

 atg aac tac gat ccc att gtg tcc aag gtc gct gag gtg ctg gcc tca     1913
 Met Asn Tyr Asp Pro Ile Val Ser Lys Val Ala Glu Val Leu Ala Ser
         555                 560                 565

 ggc cgt gcc atc cgg aag cgg gag gtg gag ctg ttt gtg ctg cac agc     1961
 Gly Arg Ala Ile Arg Lys Arg Glu Val Glu Leu Phe Val Leu His Ser
     570                 575                 580

 aag act ggc gac atg tcc tgg ctt acg ggg aaa gga tcc tga gctcaca     2010
 Lys Thr Gly Asp Met Ser Trp Leu Thr Gly Lys Gly Ser 
 585                 590                 595

 tgcagtagac ttgggcaggc aaagggggca ccaagggcac aggccaagcc ttgggggcag   2070

 gtgccaatct ccagtcccag gatcccccag ggcagaacct gagccctccc agtgcttgcc   2130

 ttcagccacc tggctcccct cctgggaggc ctctgctgga tccagaagat gctcaaccct   2190

 caaggcctct gctgccactg acagctggca ctggaggcag gacaagccct gcctcttctc   2250

 cctctattgg gactggtccc ctgaagaacc ctgcaacatg ttagacatta ccgtaaaatt   2310

 aaaacgcaca aatttgcaga aaaaaaaaa                                     2339




      <210> 218
      <211> 4204
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (398)..(2593)

      <400> 218
 gattcttttg ttcatccagc taatgaaatg aggattgggg aacttcaccc ttcattagct     60

 gagacccctc tgtacccacc caaacttgtt ctgctaggga aggacaaaaa aagaatcaac    120

 tgatgagtct gaagttgaca aaactcactg tctgaataac agtgtttcct caggcactta    180

 ctcagactac tcgccttccc aggcttcctc aggatcctct aatacccggg ttaaagtggg    240

 gtccttgcag acaacagcta aagatgcagt acataattct ttgtggggta acaggattgc    300

 accatctttc ccacagcctc ttgattcaaa gccattactc agccagcggg aggctgttcc    360

 cccaggcaat ataccacagc gtcctgaccg gctgccc atg agt gat act ttc act     415
                                          Met Ser Asp Thr Phe Thr
                                            1               5

 gac aac tgg act gat ggc tcg cat tat gac aac aca ggg ttt gtt gct      463
 Asp Asn Trp Thr Asp Gly Ser His Tyr Asp Asn Thr Gly Phe Val Ala
              10                  15                  20

 gag gaa acc aca gcc gag aat gcc aac agt aat cct ctc tta agt tcg      511
 Glu Glu Thr Thr Ala Glu Asn Ala Asn Ser Asn Pro Leu Leu Ser Ser
          25                  30                  35

 aaa tct aga agc aca tct tcg cat gga cgc agg cct ttg atc agg caa      559
 Lys Ser Arg Ser Thr Ser Ser His Gly Arg Arg Pro Leu Ile Arg Gln
      40                  45                  50

 gac agg att gtt ggt gtt ccc ctg gaa ctc gag cag tct aca cac aga      607
 Asp Arg Ile Val Gly Val Pro Leu Glu Leu Glu Gln Ser Thr His Arg
  55                  60                  65                  70

 cac aca cca gaa aca gaa gtg cct cct tcc aat cct tgg cag aat tgg      655
 His Thr Pro Glu Thr Glu Val Pro Pro Ser Asn Pro Trp Gln Asn Trp
                  75                  80                  85

 acc aga acc cct agt ccg ttt gaa gac agg acc gct ttt cct tcc aaa      703
 Thr Arg Thr Pro Ser Pro Phe Glu Asp Arg Thr Ala Phe Pro Ser Lys
              90                  95                 100

 tta gag aca acc ccc act acc agc cca ttg cct gaa agg aaa gaa cat      751
 Leu Glu Thr Thr Pro Thr Thr Ser Pro Leu Pro Glu Arg Lys Glu His
         105                 110                 115

 ata aag gaa tct act gaa ata cct agt cct ttt tct cca ggc gta cca      799
 Ile Lys Glu Ser Thr Glu Ile Pro Ser Pro Phe Ser Pro Gly Val Pro
     120                 125                 130

 tgg gag tat cat gat tcc aat ccc aac agg agt ctt agt aat gtc ttt      847
 Trp Glu Tyr His Asp Ser Asn Pro Asn Arg Ser Leu Ser Asn Val Phe
 135                 140                 145                 150

 tct caa atc cat tgc cgc ccg gaa tct tct aaa ggt gtt att tca att      895
 Ser Gln Ile His Cys Arg Pro Glu Ser Ser Lys Gly Val Ile Ser Ile
                 155                 160                 165

 agc aaa agc aca gag agg ctt tcc ccc cta atg aaa gat atc aag tct      943
 Ser Lys Ser Thr Glu Arg Leu Ser Pro Leu Met Lys Asp Ile Lys Ser
             170                 175                 180

 aat aaa ttc aaa aag tca cag agt atc gat gag att gac att ggt aca      991
 Asn Lys Phe Lys Lys Ser Gln Ser Ile Asp Glu Ile Asp Ile Gly Thr
         185                 190                 195

 tat aag gtg tat aac ata cca tta gaa aac tat gct tct ggg agt gat     1039
 Tyr Lys Val Tyr Asn Ile Pro Leu Glu Asn Tyr Ala Ser Gly Ser Asp
     200                 205                 210

 cac tta gga agc cac gaa cga ccg gat aag atg ctg gga cca gag cat     1087
 His Leu Gly Ser His Glu Arg Pro Asp Lys Met Leu Gly Pro Glu His
 215                 220                 225                 230

 ggt atg tcc agt atg tct cga agc cag tca gtc cca atg ctg gat gat     1135
 Gly Met Ser Ser Met Ser Arg Ser Gln Ser Val Pro Met Leu Asp Asp
                 235                 240                 245

 gag atg ctc acc tac gga agt agt aag ggg cca caa caa caa aaa gct     1183
 Glu Met Leu Thr Tyr Gly Ser Ser Lys Gly Pro Gln Gln Gln Lys Ala
             250                 255                 260

 tct atg aca aaa aaa gtc tat cag ttt gac caa agc ttc aat cct caa     1231
 Ser Met Thr Lys Lys Val Tyr Gln Phe Asp Gln Ser Phe Asn Pro Gln
         265                 270                 275

 gga tca gtg gaa gtg aaa gcc gaa aag agg ata cca ccc cct ttt caa     1279
 Gly Ser Val Glu Val Lys Ala Glu Lys Arg Ile Pro Pro Pro Phe Gln
     280                 285                 290

 cac aat ccc gag tac gtg caa cag gcc agc aaa aac atc gcc aag gat     1327
 His Asn Pro Glu Tyr Val Gln Gln Ala Ser Lys Asn Ile Ala Lys Asp
 295                 300                 305                 310

 ttg att agt cct aga gct tac aga gga tac cca ccg atg gag caa atg     1375
 Leu Ile Ser Pro Arg Ala Tyr Arg Gly Tyr Pro Pro Met Glu Gln Met
                 315                 320                 325

 ttt tca ttt tct cag cca tct gtg aat gag gat gct gtg gtg aat gcc     1423
 Phe Ser Phe Ser Gln Pro Ser Val Asn Glu Asp Ala Val Val Asn Ala
             330                 335                 340

 cag ttc gca agc caa ggg gcc agg gcg ggc ttc ctg aga agg gcc gac     1471
 Gln Phe Ala Ser Gln Gly Ala Arg Ala Gly Phe Leu Arg Arg Ala Asp
         345                 350                 355

 tcc ctg gtg agc gcc aca gaa atg gcc atg ttt aga agg gtc aat gag     1519
 Ser Leu Val Ser Ala Thr Glu Met Ala Met Phe Arg Arg Val Asn Glu
     360                 365                 370

 cct cat gag ctg ccc cca act gat agg tac ggc aga ccc cca tat agg     1567
 Pro His Glu Leu Pro Pro Thr Asp Arg Tyr Gly Arg Pro Pro Tyr Arg
 375                 380                 385                 390

 gga ggg ctg gat cgc caa agc agc gtt aca gtg act gag tcc cag ttc     1615
 Gly Gly Leu Asp Arg Gln Ser Ser Val Thr Val Thr Glu Ser Gln Phe
                 395                 400                 405

 ctg aaa agg aat ggc agg tat gaa gat gaa cac cct tca tat caa gaa     1663
 Leu Lys Arg Asn Gly Arg Tyr Glu Asp Glu His Pro Ser Tyr Gln Glu
             410                 415                 420

 gtg aaa gct cag gcg gga agt ttt ccg gtt aaa aac ctt acc caa agg     1711
 Val Lys Ala Gln Ala Gly Ser Phe Pro Val Lys Asn Leu Thr Gln Arg
         425                 430                 435

 agg cca ttg tct gcg aga agc tac agt aca gag agt tac ggt gcc tcc     1759
 Arg Pro Leu Ser Ala Arg Ser Tyr Ser Thr Glu Ser Tyr Gly Ala Ser
     440                 445                 450

 caa acc agg cca gtt tca gct agg cct act atg gca gct ctt ttg gaa     1807
 Gln Thr Arg Pro Val Ser Ala Arg Pro Thr Met Ala Ala Leu Leu Glu
 455                 460                 465                 470

 aaa ata cca tct gac tat aac ttg ggt aac tat ggt gac aag cca tca     1855
 Lys Ile Pro Ser Asp Tyr Asn Leu Gly Asn Tyr Gly Asp Lys Pro Ser
                 475                 480                 485

 gat aac agt gat tta aag acg agg cct act cct gtg aag gga gag gag     1903
 Asp Asn Ser Asp Leu Lys Thr Arg Pro Thr Pro Val Lys Gly Glu Glu
             490                 495                 500

 agc tgt ggt aaa atg cct gca gac tgg aga caa cag ctg ctt aga cat     1951
 Ser Cys Gly Lys Met Pro Ala Asp Trp Arg Gln Gln Leu Leu Arg His
         505                 510                 515

 ata gaa gct aga cgg tta gac agg acc ccg tcc cag caa agc aac att     1999
 Ile Glu Ala Arg Arg Leu Asp Arg Thr Pro Ser Gln Gln Ser Asn Ile
     520                 525                 530

 tta gac aat gga caa gaa gat gta tct cct agt ggc caa tgg aat cct     2047
 Leu Asp Asn Gly Gln Glu Asp Val Ser Pro Ser Gly Gln Trp Asn Pro
 535                 540                 545                 550

 tat cca ctt ggg agg cgg gat gta cct ccg gac acc att act aag aag     2095
 Tyr Pro Leu Gly Arg Arg Asp Val Pro Pro Asp Thr Ile Thr Lys Lys
                 555                 560                 565

 gca ggc agc cac atc cag acg ttg atg ggg tcc caa agc ctt cag cat     2143
 Ala Gly Ser His Ile Gln Thr Leu Met Gly Ser Gln Ser Leu Gln His
             570                 575                 580

 cgc agc cgg gag cag cag ccg tat gaa gga aat ata aac aaa gtg acc     2191
 Arg Ser Arg Glu Gln Gln Pro Tyr Glu Gly Asn Ile Asn Lys Val Thr
         585                 590                 595

 atc cag caa ttt cag tca cca ttg cct att cag atc ccc tct tca cag     2239
 Ile Gln Gln Phe Gln Ser Pro Leu Pro Ile Gln Ile Pro Ser Ser Gln
     600                 605                 610

 gcc acc cgg gga cct cag cct gga cgg tgc tta att caa act aaa ggg     2287
 Ala Thr Arg Gly Pro Gln Pro Gly Arg Cys Leu Ile Gln Thr Lys Gly
 615                 620                 625                 630

 caa agg agt atg gat gga tat cca gag cag ttt tgt gtg aga ata gaa     2335
 Gln Arg Ser Met Asp Gly Tyr Pro Glu Gln Phe Cys Val Arg Ile Glu
                 635                 640                 645

 aag aat cct ggc ctt gga ttt agt atc agt ggt gga att agt gga caa     2383
 Lys Asn Pro Gly Leu Gly Phe Ser Ile Ser Gly Gly Ile Ser Gly Gln
             650                 655                 660

 gga aat cca ttc aaa cct tct gac aag ggt atc ttt gtt act agg gtt     2431
 Gly Asn Pro Phe Lys Pro Ser Asp Lys Gly Ile Phe Val Thr Arg Val
         665                 670                 675

 cag cct gat ggg cca gca tca aac cta ctg cag cct ggt gat aag atc     2479
 Gln Pro Asp Gly Pro Ala Ser Asn Leu Leu Gln Pro Gly Asp Lys Ile
     680                 685                 690

 ctt cag gca aat gga cac agt ttt gta cat atg gaa cat gaa aaa gct     2527
 Leu Gln Ala Asn Gly His Ser Phe Val His Met Glu His Glu Lys Ala
 695                 700                 705                 710

 gta tta cta ctg aag agt ttc cag aac aca gta gac cta gtt att caa     2575
 Val Leu Leu Leu Lys Ser Phe Gln Asn Thr Val Asp Leu Val Ile Gln
                 715                 720                 725

 cgt gag ctt act gtc taa atattt tttataaata gtgaagatac gtctagccag     2629
 Arg Glu Leu Thr Val 
             730

 acctaatgtt caaaaataaa tttatacata gaaacaaatt ttgccaattg ctggaccaat   2689

 ggcaaacatt agtgccaaat gtataatact atatgttagc actgaccatc cttaaaaaat   2749

 gttaactcta taaatatgat gttcatgtgg ttatgtatta gttttaattg tcagcctctg   2809

 gctgtgcatt ggtgcagttt tgtttctgtt tttgtttttg tttttaatca aataagtttc   2869

 ttctcaaaat ggatttcata taatttcgga gcacggaagc acacacaagc tctttatgaa   2929

 ttctgctctc catcagaaac actgcctcaa agttgtatat gcctttatat agaaaataca   2989

 aatataaaga attgtaattc ccataaaata tttctagcac aaggtatatg ttggcatata   3049

 tacaaaaaga atatagagaa aaacaatatt ttcataaact aaacatctca gatagagaaa   3109

 aaatatatct taaaataaga ctttactata ttgaatcttt ttcaataaaa attacatgat   3169

 aatgccttat gaaagtaact gtacatatgg tataaagtgt ttatatttgg ttccatattc   3229

 atttgctaaa ttctcatgac acagagtgaa atatttcata aattagccat ttatctctgg   3289

 gacccaaata aaaataggat gaactaattt gttcaatgcc tttagctaat tacaatacat   3349

 gcagagttta gaaacagact aaaggtcatt gtagttaagt ctttttcacc acaaatttaa   3409

 gcagtggatg atgggtggca ggaaaggtat tgctttattt ctttcaagtt catgttgatt   3469

 ataaactgta gcccctgtga tttctttact tgtaaatgtg gaatttattt gtgtgttgct   3529

 taatctaatt tgctgctttt taaattattt aaaacgaatt ttggaaattg ataaaattta   3589

 tcattacgaa agactgctgt tagaaagtta tggtaggtga ttttaaatcc ttggtattta   3649

 aatatgaaac ttcaaatata atttctcaga gctgtggtct acctgtatca ttaatttcaa   3709

 tggctgtttt tctgggcaga aatagataaa atactttttt tccaaaaaca gtttcaaggt   3769

 atgtaaaatc ctgaatgctt tttcactgaa gagaaagaca agcatggtta atgtagaatt   3829

 atttactttt ccattgaaac tattttcctg cataaatgat caaaatttat tttataatcc   3889

 tttaaaatac ttatctttca tattagtcat taatttaatt acaatattaa tttgaatttc   3949

 caggataatt tcccggagtt ggttgcatgc attatctttc ataattttac atagttcttt   4009

 tgttatataa tgaatttact ttacatgcta gtgtttcaag tattgtatga ggattttcac   4069

 aatagtatca ctgaatgatg tcaccagagc tctgagaata atatttgtaa gttaactgtt   4129

 ttatggggac attgaaaata ttgtattttt gtagggtcta ttaaaatgag tgtcacttat   4189

 tagaaaaaaa aaaaa                                                    4204




      <210> 219
      <211> 1797
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(1787)

      <400> 219
 cgacgatttc gtcg  atg ctg gcg cag gtt tca cca cac ggg aag ctg tct      50
                  Met Leu Ala Gln Val Ser Pro His Gly Lys Leu Ser
                    1               5                  10

 gcc cgg cgc tca tgg gac ctg ctc tca ggc ttt ccc agg tac ctg gtt       98
 Ala Arg Arg Ser Trp Asp Leu Leu Ser Gly Phe Pro Arg Tyr Leu Val
          15                  20                  25

 ctg gag cac gtc tcg ggg ggt gag cta ttc gac tac ctg gta aag aag      146
 Leu Glu His Val Ser Gly Gly Glu Leu Phe Asp Tyr Leu Val Lys Lys
      30                  35                  40

 ggg aga ctg acg ccc aag gag gcc cga aag ttc ttc cgc cag att gtg      194
 Gly Arg Leu Thr Pro Lys Glu Ala Arg Lys Phe Phe Arg Gln Ile Val
  45                  50                  55                  60

 tct gcg ctg gac ttc tgc cac agc tac tcc atc tgc cac aga gac cta      242
 Ser Ala Leu Asp Phe Cys His Ser Tyr Ser Ile Cys His Arg Asp Leu
                  65                  70                  75

 aag ccc gag aac ctg ctt ttg gat gag aaa aac aac atc cgc att gca      290
 Lys Pro Glu Asn Leu Leu Leu Asp Glu Lys Asn Asn Ile Arg Ile Ala
              80                  85                  90

 gac ttc ggc atg gcg tcc ctg cag gtg ggg gac agc ctc ctg gag acc      338
 Asp Phe Gly Met Ala Ser Leu Gln Val Gly Asp Ser Leu Leu Glu Thr
          95                 100                 105

 agc tgc ggg tcc ccc cat tat gcg tgt cca gag gtg att aag ggg gaa      386
 Ser Cys Gly Ser Pro His Tyr Ala Cys Pro Glu Val Ile Lys Gly Glu
     110                 115                 120

 aaa tat gat ggc cgc cgg gca gac atg tgg agc tgt gga gtc atc ctc      434
 Lys Tyr Asp Gly Arg Arg Ala Asp Met Trp Ser Cys Gly Val Ile Leu
 125                 130                 135                 140

 ttc gcc ctg ctc gtg ggg gct ctg ccc ttt gat gac gac aac ctc cgc      482
 Phe Ala Leu Leu Val Gly Ala Leu Pro Phe Asp Asp Asp Asn Leu Arg
                 145                 150                 155

 cag ctg ctg gag aag gtg aaa cgg ggc gtc ttc cac atg ccc cac ttc      530
 Gln Leu Leu Glu Lys Val Lys Arg Gly Val Phe His Met Pro His Phe
             160                 165                 170

 att cct cca gat tgc cag agc ctc ctg agg gga atg atc gaa gtg gag      578
 Ile Pro Pro Asp Cys Gln Ser Leu Leu Arg Gly Met Ile Glu Val Glu
         175                 180                 185

 ccc gaa aaa agg ctc agt ctg gag caa att cag aaa cat cct tgg tac      626
 Pro Glu Lys Arg Leu Ser Leu Glu Gln Ile Gln Lys His Pro Trp Tyr
     190                 195                 200

 cta ggc ggg aaa cac gag cca gac ccg tgc ctg gag cca gcc cct ggc      674
 Leu Gly Gly Lys His Glu Pro Asp Pro Cys Leu Glu Pro Ala Pro Gly
 205                 210                 215                 220

 cgc cgg gta gcc atg cgg agc ctg cca tcc aac gga gag ctg gac ccc      722
 Arg Arg Val Ala Met Arg Ser Leu Pro Ser Asn Gly Glu Leu Asp Pro
                 225                 230                 235

 gac gtc cta gag agc atg gca tca ctg ggc tgc ttc agg gac cgc gag      770
 Asp Val Leu Glu Ser Met Ala Ser Leu Gly Cys Phe Arg Asp Arg Glu
             240                 245                 250

 agg ctg cat cgc gag ctg cgc agt gag gag gag aac caa gaa aag atg      818
 Arg Leu His Arg Glu Leu Arg Ser Glu Glu Glu Asn Gln Glu Lys Met
         255                 260                 265

 ata tat tat ctg ctt ttg gat cgg aag gag cgg tat ccc agc tgt gag      866
 Ile Tyr Tyr Leu Leu Leu Asp Arg Lys Glu Arg Tyr Pro Ser Cys Glu
     270                 275                 280

 gac cag gac ctg cct ccc cgg aat gat gtt gac ccc ccc cgg aag cgt      914
 Asp Gln Asp Leu Pro Pro Arg Asn Asp Val Asp Pro Pro Arg Lys Arg
 285                 290                 295                 300

 gtg gat tct ccc atg ctg agc cgt cac ggg aag cgg cga cca gag cgg      962
 Val Asp Ser Pro Met Leu Ser Arg His Gly Lys Arg Arg Pro Glu Arg
                 305                 310                 315

 aag tcc atg gaa gtc ctg agc atc acc gat gcc ggg ggt ggt ggc tcc     1010
 Lys Ser Met Glu Val Leu Ser Ile Thr Asp Ala Gly Gly Gly Gly Ser
             320                 325                 330

 cct gta ccc acc cga cgg gcc ttg gag atg gcc cag cac agc cag agg     1058
 Pro Val Pro Thr Arg Arg Ala Leu Glu Met Ala Gln His Ser Gln Arg
         335                 340                 345

 ctg gca aaa cgc tcc tgg ttc ggg aac ttc atc tcc ttg gac aaa gaa     1106
 Leu Ala Lys Arg Ser Trp Phe Gly Asn Phe Ile Ser Leu Asp Lys Glu
     350                 355                 360

 gaa caa ata ttc ctc gtg cta aag gac aaa cct ctc agc agc atc aaa     1154
 Glu Gln Ile Phe Leu Val Leu Lys Asp Lys Pro Leu Ser Ser Ile Lys
 365                 370                 375                 380

 gca gac atc gtc cat gcc ttt ctg tcg atc ccc agc ctg agt cac agt     1202
 Ala Asp Ile Val His Ala Phe Leu Ser Ile Pro Ser Leu Ser His Ser
                 385                 390                 395

 gtg ctg tca cag acc agc ttc agg gcc gag tac aag gcc agt ggc ggc     1250
 Val Leu Ser Gln Thr Ser Phe Arg Ala Glu Tyr Lys Ala Ser Gly Gly
             400                 405                 410

 ccc tcc gtc ttc caa aag ccc gtc cgc ttc cag gtg gac atc agc tcc     1298
 Pro Ser Val Phe Gln Lys Pro Val Arg Phe Gln Val Asp Ile Ser Ser
         415                 420                 425

 tct gag ggt cca gag ccc tcc ccg cga cgg gac ggc agc gga ggt ggt     1346
 Ser Glu Gly Pro Glu Pro Ser Pro Arg Arg Asp Gly Ser Gly Gly Gly
     430                 435                 440

 ggc atc tac tcc gtc acc ttc act ctc atc tcg ggt ccc agc cgt cgg     1394
 Gly Ile Tyr Ser Val Thr Phe Thr Leu Ile Ser Gly Pro Ser Arg Arg
 445                 450                 455                 460

 ttc aag cga gtg gtg gag acc atc cag gca cag ctc ctg agc act cat     1442
 Phe Lys Arg Val Val Glu Thr Ile Gln Ala Gln Leu Leu Ser Thr His
                 465                 470                 475

 gac cag ccc tcc gtg cag gcc ctg gca gac gag aag aac ggg gcc cag     1490
 Asp Gln Pro Ser Val Gln Ala Leu Ala Asp Glu Lys Asn Gly Ala Gln
             480                 485                 490

 acc cgg cct gct ggt gcc cca ccc cga agc ctg cag ccc cca ccc ggc     1538
 Thr Arg Pro Ala Gly Ala Pro Pro Arg Ser Leu Gln Pro Pro Pro Gly
         495                 500                 505

 cgc cca gac cca gag ctg ttt cta ttt tat tta ttg att aat tta tta     1586
 Arg Pro Asp Pro Glu Leu Phe Leu Phe Tyr Leu Leu Ile Asn Leu Leu
     510                 515                 520

 ttt tat tta ttg atc aat ctc tct gcg ggg tgg ggt ggg gga ggg acg     1634
 Phe Tyr Leu Leu Ile Asn Leu Ser Ala Gly Trp Gly Gly Gly Gly Thr
 525                 530                 535                 540

 gga gct ggt tgg ggt ggc tta gca gat ccg gac agg gcc ctc tgt ccc     1682
 Gly Ala Gly Trp Gly Gly Leu Ala Asp Pro Asp Arg Ala Leu Cys Pro
                 545                 550                 555

 tgt gtc gtc ccc aac ccc ctc ttc ccg ggc ccc tcc tcc cct ggt cct     1730
 Cys Val Val Pro Asn Pro Leu Phe Pro Gly Pro Ser Ser Pro Gly Pro
             560                 565                 570

 ccc ccc acg acc ttc tgt acg gat ttg ctc tcc gga agg aat tct ggt     1778
 Pro Pro Thr Thr Phe Cys Thr Asp Leu Leu Ser Gly Arg Asn Ser Gly
         575                 580                 585

 ttc gcg tga aaaaaaaaaa                                              1797
 Phe Ala 
     590





      <210> 220
      <211> 1064
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1014)

      <400> 220
  atg gag act atg cga gcg cag cgg ctg cag cct ggt gtg ggc acc agc      48
  Met Glu Thr Met Arg Ala Gln Arg Leu Gln Pro Gly Val Gly Thr Ser
    1               5                  10                  15

 ggg agg ggc act ctc cga gcg ctg cgg ccc gga gtg act ggg gcc gcg       96
 Gly Arg Gly Thr Leu Arg Ala Leu Arg Pro Gly Val Thr Gly Ala Ala
              20                  25                  30

 gct gcc acc gcc aca ccc cct gcg ggc ccc ccg cct gcc ccg ccg cct      144
 Ala Ala Thr Ala Thr Pro Pro Ala Gly Pro Pro Pro Ala Pro Pro Pro
          35                  40                  45

 ccc gca ccg ccc ccg ccg ccg ctg ctc ctg tct ggg gcc cca gga cta      192
 Pro Ala Pro Pro Pro Pro Pro Leu Leu Leu Ser Gly Ala Pro Gly Leu
      50                  55                  60

 ccc ctg ccc ccc ggc gcc gcc ggc agc ccg gca gtg ctg cga gag gcc      240
 Pro Leu Pro Pro Gly Ala Ala Gly Ser Pro Ala Val Leu Arg Glu Ala
  65                  70                  75                  80

 gtg gag gcc gtg gtg agg agc ttc gcc aag cac acg cag ggc tat ggc      288
 Val Glu Ala Val Val Arg Ser Phe Ala Lys His Thr Gln Gly Tyr Gly
                  85                  90                  95

 cga gtg aat gtg gtg gag gca ctt cag gaa ttc tgg cag atg aag cag      336
 Arg Val Asn Val Val Glu Ala Leu Gln Glu Phe Trp Gln Met Lys Gln
             100                 105                 110

 tcc cgt ggt gct gac tta aag aat ggg gct cta gtg gtt tat gag atg      384
 Ser Arg Gly Ala Asp Leu Lys Asn Gly Ala Leu Val Val Tyr Glu Met
         115                 120                 125

 gtt ccc tcc aac agc cct cct tat gtc tgc tat gtc acc ctg cct ggg      432
 Val Pro Ser Asn Ser Pro Pro Tyr Val Cys Tyr Val Thr Leu Pro Gly
     130                 135                 140

 gga agc tgc ttt ggg agt ttc cag ttt tgc ccc aca aaa gct gag gcc      480
 Gly Ser Cys Phe Gly Ser Phe Gln Phe Cys Pro Thr Lys Ala Glu Ala
 145                 150                 155                 160

 cgg agg agt gct gca aag att gcg cta atg aat tct gtg ttt aat gaa      528
 Arg Arg Ser Ala Ala Lys Ile Ala Leu Met Asn Ser Val Phe Asn Glu
                 165                 170                 175

 cat cct tcc cga aga atc act gat gag ttc atc gag aag agt gtc tct      576
 His Pro Ser Arg Arg Ile Thr Asp Glu Phe Ile Glu Lys Ser Val Ser
             180                 185                 190

 gag gcc ctg gca tct ttt aat ggc aac agg gag gaa gct gac aac cca      624
 Glu Ala Leu Ala Ser Phe Asn Gly Asn Arg Glu Glu Ala Asp Asn Pro
         195                 200                 205

 aat aca ggg att ggt gcc ttc cga ttc atg ctg gaa tcc aac aag ggc      672
 Asn Thr Gly Ile Gly Ala Phe Arg Phe Met Leu Glu Ser Asn Lys Gly
     210                 215                 220

 aaa tca atg ttg gag ttc cag gag cta atg aca gtt ttt caa ctg cta      720
 Lys Ser Met Leu Glu Phe Gln Glu Leu Met Thr Val Phe Gln Leu Leu
 225                 230                 235                 240

 cac tgg aat ggc agc ctt aag gcc atg agg gaa cga caa tgc tct cgg      768
 His Trp Asn Gly Ser Leu Lys Ala Met Arg Glu Arg Gln Cys Ser Arg
                 245                 250                 255

 cag gag gtg ttg gct cat tat tcg cac cgg gcc ctg gat gat gat att      816
 Gln Glu Val Leu Ala His Tyr Ser His Arg Ala Leu Asp Asp Asp Ile
             260                 265                 270

 cgc cac caa atg gcc ttg gac tgg gtg agc cgg gag cag agt gtg ccg      864
 Arg His Gln Met Ala Leu Asp Trp Val Ser Arg Glu Gln Ser Val Pro
         275                 280                 285

 ggg gca ctg tct aga gag ctg gcc tct act gag cgg gag ctg gat gaa      912
 Gly Ala Leu Ser Arg Glu Leu Ala Ser Thr Glu Arg Glu Leu Asp Glu
     290                 295                 300

 gcc cga ctg gca ggc aag gag ctg cgc ttc cac aag gag aag aaa gat      960
 Ala Arg Leu Ala Gly Lys Glu Leu Arg Phe His Lys Glu Lys Lys Asp
 305                 310                 315                 320

 att ctt gtg ctg gct gct ggg cag ttg ggc aat atg cat tct tcc aac     1008
 Ile Leu Val Leu Ala Ala Gly Gln Leu Gly Asn Met His Ser Ser Asn
                 325                 330                 335

 tgc tag gcatccaccc acataactcc ccaggctttc cacagccttt tttttatgtc      1064
 Cys 






      <210> 221
      <211> 2494
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (49)..(723)

      <400> 221
 ggccctgcat actcacatct gacggagttt gcaccacccc caactccc atg gtg gat      57
                                                      Met Val Asp
                                                        1

 cac ctg gtt gca tcc aac cct ttt gaa gat gac ttc gga gcc ccc aaa      105
 His Leu Val Ala Ser Asn Pro Phe Glu Asp Asp Phe Gly Ala Pro Lys
       5                  10                  15

 gtg ggg gtt gca gcc cct cca ttc ctt ggc agt cct gtg ccc ttc gga      153
 Val Gly Val Ala Ala Pro Pro Phe Leu Gly Ser Pro Val Pro Phe Gly
  20                  25                  30                  35

 ggc ttc cgt gtg cag ggg ggc atg gcg ggc cag aga cct ggt cag ggg      201
 Gly Phe Arg Val Gln Gly Gly Met Ala Gly Gln Arg Pro Gly Gln Gly
                  40                  45                  50

 ctc ccc agc ctg ccg cct aac aca agt ccc ttt cct ggt ccg gac cct      249
 Leu Pro Ser Leu Pro Pro Asn Thr Ser Pro Phe Pro Gly Pro Asp Pro
              55                  60                  65

 ggc ttt cct ggc cct ggt ggt gag gat ggg ggg aag ccc ttg aat cca      297
 Gly Phe Pro Gly Pro Gly Gly Glu Asp Gly Gly Lys Pro Leu Asn Pro
          70                  75                  80

 cct gct tct act gct ttt ccc cag gag ccc cac tca ggc tcc ccg gct      345
 Pro Ala Ser Thr Ala Phe Pro Gln Glu Pro His Ser Gly Ser Pro Ala
      85                  90                  95

 gct gct gtt aat ggg aac cag ccc agt ttc ccc ccg aac agc agt ggg      393
 Ala Ala Val Asn Gly Asn Gln Pro Ser Phe Pro Pro Asn Ser Ser Gly
 100                 105                 110                 115

 cgg ggt ggg ggc act cca gat gcc aac agc ttg gca ccc cct ggc aag      441
 Arg Gly Gly Gly Thr Pro Asp Ala Asn Ser Leu Ala Pro Pro Gly Lys
                 120                 125                 130

 gca ggt ggg ggc tcc ggg ccc cag cct ccc cca ggc ttg gtg tac cca      489
 Ala Gly Gly Gly Ser Gly Pro Gln Pro Pro Pro Gly Leu Val Tyr Pro
             135                 140                 145

 tgt ggt gcc tgt cgg agt gag gtg aac gat gac cag gat gcc att ctg      537
 Cys Gly Ala Cys Arg Ser Glu Val Asn Asp Asp Gln Asp Ala Ile Leu
         150                 155                 160

 tgt gag gcc tcc tgc cag aaa tgg ttc cac cgt gag tgc aca ggc atg      585
 Cys Glu Ala Ser Cys Gln Lys Trp Phe His Arg Glu Cys Thr Gly Met
     165                 170                 175

 act gag agc gcc tat ggg ctg ctg acc act gaa gct tct gcc gtc tgg      633
 Thr Glu Ser Ala Tyr Gly Leu Leu Thr Thr Glu Ala Ser Ala Val Trp
 180                 185                 190                 195

 gcc tgc gat ctc tgc ctc aag acc aag gag atc cag tct gtc tac atc      681
 Ala Cys Asp Leu Cys Leu Lys Thr Lys Glu Ile Gln Ser Val Tyr Ile
                 200                 205                 210

 cgt gag ggc atg ggg cag ctg gtg gct gct aac gat ggg tga cgctggt      730
 Arg Glu Gly Met Gly Gln Leu Val Ala Ala Asn Asp Gly 
             215                 220

 gaagtggccc agggaagtgc acatgtctct ccctgctctt ccagggtgat ttttttgatg    790

 tttggctctt ggtccttgtt tccactggct ttccatcccc atggggcaga aacagtggct    850

 cctgggagca gaaaaggaat tgaggtgggc aggcagaaga gcctggattg ctcactgttt    910

 tgggaaactt acatgttgag atctacagat atccatgaaa ctaaagccct gctgagcaga    970

 gccattttgt ggctatttct ggaggcccag gagtgtggct gcaagagaaa aggggctgga   1030

 ggaagatccg gagggcaggg gtgttccctc tgctgatgat ggatgcccct aacacctgtg   1090

 cctaacaccc ctactgaacc ccacagctcc agccttagtt tttggagtca agtgttaaag   1150

 gtttctggcc agaggaattg gggtcttgcc atccctgcaa tagccctttt atgggctctg   1210

 ggagacagct ttagggaata aatggggatt ttcccctttt tctacccact cctttgcttc   1270

 ctccaagact tacccaactc cttccccctc agagaaccaa atagcctgag gaagcaggag   1330

 agttcctggt tatggcagtt tcttggtgat ttggggcttc aagacagtag gtgagagatg   1390

 ctgtcaggac gtatcttctt cataccaaag tcactggtcc tttctcagcc tctctcgtgc   1450

 ttttctccta atgaccatat ttttgccaaa aattgggata tgttatctga cagaccagaa   1510

 tatttgaagt ttgggctgtc ctgaaagtct ggactttggt ggtaccctcc tcccccagcc   1570

 catctgttgc acattatact ccgtgtgttc ttcaactttc ggcgccctta ttcccctgcc   1630

 ttcctggctt gattgaagga aagcttgaaa aggcgcagag ccctatacct catttcctcc   1690

 atgataaaag gatccaagtg aggccctgtc acagcctgtg ggtaggggat gcggcgggat   1750

 cctcattgcc atggtactca aaggtagaag agcctggagt ttgttgcttc tctttgctat   1810

 tctttcatat cctcttgggc ctggtgatta attagcaatt ctcattcctc tcagccaaag   1870

 gcctgcactg ggctttattt gtcttttttt attttttaag cactgcctgc cagagatggg   1930

 cctggggcct gatgaggacc ttagcgctgc tcgttctcct tttctgttca tgcacacatt   1990

 cctccatggg gtggggggtg gggaaggcag gcatggggtg tggccctcgg agaagttagg   2050

 agtcccccag ctcaagatac agtggcaaag acctagtggt cccctacccc cacttctctc   2110

 agttcctggc atgaggagag aagaccctgc tctggtggag ctgacaacct ttgaggctgg   2170

 gaggagagca gcctctgggc atcgttccca gtgtccctca cactaaaacg gcgtagatgg   2230

 caacccccca cccccacccc gctgctcaac tcttgtgttt gttgttctgt ttgccccatt   2290

 tatctgttgc tgtttttgtg ttgtcttccc ctgctccgca ttttgtaaaa tggcccctgg   2350

 gggagtgttt ttgctggatc tgctccctct cgctctctca ctccactact ttttggaaca   2410

 aagtgatggc agaatgcggt ggtggtgggg gtcttttgta ctgttggatt aataaaatga   2470

 ttttaaaatc ccaaaaaaaa aaaa                                          2494




      <210> 222
      <211> 5064
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (24)..(4253)

      <400> 222
 cggctggcag ctgtggcgcc gac    atg gct gcg ctg gtg gag ccg ctg ggg      50
                              Met Ala Ala Leu Val Glu Pro Leu Gly
                                1               5

 ctg gag cgg gac gtg tcc cgg gcg gtt gag ctc ctc gag cgg ctc cag       98
 Leu Glu Arg Asp Val Ser Arg Ala Val Glu Leu Leu Glu Arg Leu Gln
  10                  15                  20                  25

 cgc agc ggg gag ctg ccg ccg cag aag ctg cag gcc ctc cag cga gtt      146
 Arg Ser Gly Glu Leu Pro Pro Gln Lys Leu Gln Ala Leu Gln Arg Val
                  30                  35                  40

 ctg cag agc cgc ttc tgc tcc gct atc cga gag gtg tat gag cag ctt      194
 Leu Gln Ser Arg Phe Cys Ser Ala Ile Arg Glu Val Tyr Glu Gln Leu
              45                  50                  55

 tat gac acg ctg gac atc acc ggc agc gcc gag atc cga gcc cat gcc      242
 Tyr Asp Thr Leu Asp Ile Thr Gly Ser Ala Glu Ile Arg Ala His Ala
          60                  65                  70

 aca gcc aag agc gtt gag ggt gag cag cat gag aag gcg gtg gag ctg      290
 Thr Ala Lys Ser Val Glu Gly Glu Gln His Glu Lys Ala Val Glu Leu
      75                  80                  85

 ctg aag gcg gcc cag ggc tcg gtg aag ctg gtt gtc cgt tac aca ccg      338
 Leu Lys Ala Ala Gln Gly Ser Val Lys Leu Val Val Arg Tyr Thr Pro
  90                  95                 100                 105

 cga gtg ctg gag gag atg gag gcc cgg ttc gag aag atg cgc tct gcc      386
 Arg Val Leu Glu Glu Met Glu Ala Arg Phe Glu Lys Met Arg Ser Ala
                 110                 115                 120

 cgc cgg cgc caa cag cat cag agc tac tcg ttc ctg gga ctc cag ctg      434
 Arg Arg Arg Gln Gln His Gln Ser Tyr Ser Phe Leu Gly Leu Gln Leu
             125                 130                 135

 ctc cct gag gat cca ggg ctt ctg aat ttt cct att ctg gtc gcc gtg      482
 Leu Pro Glu Asp Pro Gly Leu Leu Asn Phe Pro Ile Leu Val Ala Val
         140                 145                 150

 ggg acc atg gca ccc ggg gat gca gct ccc acc ccg ttc ggg aag cct      530
 Gly Thr Met Ala Pro Gly Asp Ala Ala Pro Thr Pro Phe Gly Lys Pro
     155                 160                 165

 gtc cgt gtc tac acc tct gct ggc ccc agg aac cag gtc ttc aca gcc      578
 Val Arg Val Tyr Thr Ser Ala Gly Pro Arg Asn Gln Val Phe Thr Ala
 170                 175                 180                 185

 tca tca ctc tgc ccc atc aac ttc aca tct cct gtg gcc cta cca aac      626
 Ser Ser Leu Cys Pro Ile Asn Phe Thr Ser Pro Val Ala Leu Pro Asn
                 190                 195                 200

 ccc tgt ctc atc ctc atg tca ccc cag gcc cgc acc gcc gcc atg atg      674
 Pro Cys Leu Ile Leu Met Ser Pro Gln Ala Arg Thr Ala Ala Met Met
             205                 210                 215

 tgc gag gtg atg ccc acc atc agc gag gat ggc cgg cgg ggc tcg gcg      722
 Cys Glu Val Met Pro Thr Ile Ser Glu Asp Gly Arg Arg Gly Ser Ala
         220                 225                 230

 ctg ggc ccg gac gag gcg ggc ggg gag ctg gag cgc ctc atg gtc acg      770
 Leu Gly Pro Asp Glu Ala Gly Gly Glu Leu Glu Arg Leu Met Val Thr
     235                 240                 245

 atg ctc acg gag cgc gag cgc ctg ctg gag acg ctg cgc gag gca cag      818
 Met Leu Thr Glu Arg Glu Arg Leu Leu Glu Thr Leu Arg Glu Ala Gln
 250                 255                 260                 265

 gac ggg ttg gct aca gcg cag ctg cgg ctg cgc gag ctc ggc cac gag      866
 Asp Gly Leu Ala Thr Ala Gln Leu Arg Leu Arg Glu Leu Gly His Glu
                 270                 275                 280

 aag gac tcg ctg cag cgc cag ctc agc atc gcg ctg ccc cag gag ttt      914
 Lys Asp Ser Leu Gln Arg Gln Leu Ser Ile Ala Leu Pro Gln Glu Phe
             285                 290                 295

 gca gct ctg acg aag gag ctg aac tta tgt cgg gag cag ctg ctg gag      962
 Ala Ala Leu Thr Lys Glu Leu Asn Leu Cys Arg Glu Gln Leu Leu Glu
         300                 305                 310

 agg gag gaa gag att gca gag ctg aag gcg gaa cgg aac aac acg cgg     1010
 Arg Glu Glu Glu Ile Ala Glu Leu Lys Ala Glu Arg Asn Asn Thr Arg
     315                 320                 325

 ctg ctc ctg gaa cac ctg gag tgc ctg gtg tcc agg cac gag agg tca     1058
 Leu Leu Leu Glu His Leu Glu Cys Leu Val Ser Arg His Glu Arg Ser
 330                 335                 340                 345

 ctg cgc atg acc gtg gtg aag cgc cag gcc cag tcc ccg ggt ggg gtc     1106
 Leu Arg Met Thr Val Val Lys Arg Gln Ala Gln Ser Pro Gly Gly Val
                 350                 355                 360

 tcc tcg gag gta gaa gtg ctc aaa gct cta aag tct ctc ttc gag cac     1154
 Ser Ser Glu Val Glu Val Leu Lys Ala Leu Lys Ser Leu Phe Glu His
             365                 370                 375

 cac aag gcc ctg gat gag aag gtc cgg gag cgg ctg cgg atg gcg ctg     1202
 His Lys Ala Leu Asp Glu Lys Val Arg Glu Arg Leu Arg Met Ala Leu
         380                 385                 390

 gag cgc gtg gca gtg ctc gag gag gag ctg gaa ctg agc aat cag gag     1250
 Glu Arg Val Ala Val Leu Glu Glu Glu Leu Glu Leu Ser Asn Gln Glu
     395                 400                 405

 act ctg aac ctt cga gaa cag ctg tct agg cgg cgg tca ggg ctg gaa     1298
 Thr Leu Asn Leu Arg Glu Gln Leu Ser Arg Arg Arg Ser Gly Leu Glu
 410                 415                 420                 425

 gag ccg ggc aag gat ggg gat ggg cag act ctt gcc aat ggc ctg ggt     1346
 Glu Pro Gly Lys Asp Gly Asp Gly Gln Thr Leu Ala Asn Gly Leu Gly
                 430                 435                 440

 cct ggc ggg gat tcc aac cgg cgc aca gca gag ctg gag gag gcc ctg     1394
 Pro Gly Gly Asp Ser Asn Arg Arg Thr Ala Glu Leu Glu Glu Ala Leu
             445                 450                 455

 gag cgg cag cgc gcc gag gtg tgc cag ctg cgg gag cgc ctg gcg gtg     1442
 Glu Arg Gln Arg Ala Glu Val Cys Gln Leu Arg Glu Arg Leu Ala Val
         460                 465                 470

 ctg tgc cgt cag atg agc cag ctg gag gag gag ttg ggc acc gcg cac     1490
 Leu Cys Arg Gln Met Ser Gln Leu Glu Glu Glu Leu Gly Thr Ala His
     475                 480                 485

 cgt gag ctg ggc aag gca gag gaa gcc aac tcc aag ctg cag cgc gac     1538
 Arg Glu Leu Gly Lys Ala Glu Glu Ala Asn Ser Lys Leu Gln Arg Asp
 490                 495                 500                 505

 ctc aag gag gcg ctg gcg cag cgg gaa gat atg gag gag cgg att aca     1586
 Leu Lys Glu Ala Leu Ala Gln Arg Glu Asp Met Glu Glu Arg Ile Thr
                 510                 515                 520

 aca ctg gag aag cgc tac ctg agc gcc cag cgg gag gcc acg tct ctg     1634
 Thr Leu Glu Lys Arg Tyr Leu Ser Ala Gln Arg Glu Ala Thr Ser Leu
             525                 530                 535

 cac gac gcc aac gac aaa ctg gag aac gag tta gct agc aag gag tcg     1682
 His Asp Ala Asn Asp Lys Leu Glu Asn Glu Leu Ala Ser Lys Glu Ser
         540                 545                 550

 ttg tat cgg cag agt gaa gag aag agc cgt cag ctg gcc gag tgg ttg     1730
 Leu Tyr Arg Gln Ser Glu Glu Lys Ser Arg Gln Leu Ala Glu Trp Leu
     555                 560                 565

 gac gac gcc aag cag aag ctg cag cag acg ctg cag aaa gcg gag acc     1778
 Asp Asp Ala Lys Gln Lys Leu Gln Gln Thr Leu Gln Lys Ala Glu Thr
 570                 575                 580                 585

 ttg ccc gag ata gag gcg cag ctg gcg cag cgc gtg gcg gcg ctc aac     1826
 Leu Pro Glu Ile Glu Ala Gln Leu Ala Gln Arg Val Ala Ala Leu Asn
                 590                 595                 600

 aag gcc gag gaa cgt cat ggg aat ttt gag gag cgg ctt cgg cag ctg     1874
 Lys Ala Glu Glu Arg His Gly Asn Phe Glu Glu Arg Leu Arg Gln Leu
             605                 610                 615

 gag gcc cag ctg gaa gag aag aat caa gag ctg cag cgg gcc cgg cag     1922
 Glu Ala Gln Leu Glu Glu Lys Asn Gln Glu Leu Gln Arg Ala Arg Gln
         620                 625                 630

 cgg gag aag atg aac gat gac cac aat aag cgg ctg tcc gag acg gtg     1970
 Arg Glu Lys Met Asn Asp Asp His Asn Lys Arg Leu Ser Glu Thr Val
     635                 640                 645

 gac aag ctg ctg agc gag tcc aac gag cgc tta cag ctt cac ctc aag     2018
 Asp Lys Leu Leu Ser Glu Ser Asn Glu Arg Leu Gln Leu His Leu Lys
 650                 655                 660                 665

 gag cgc atg ggg gcg ctg gag gag aag aac tcc ctg agc gag gag ata     2066
 Glu Arg Met Gly Ala Leu Glu Glu Lys Asn Ser Leu Ser Glu Glu Ile
                 670                 675                 680

 gcc aac atg aag aag ctt cag gat gag ttg ctg cta aac aag gag cag     2114
 Ala Asn Met Lys Lys Leu Gln Asp Glu Leu Leu Leu Asn Lys Glu Gln
             685                 690                 695

 ctc ttg gcc gaa atg gag cgg atg cag atg gag atc gac cag ctg cgg     2162
 Leu Leu Ala Glu Met Glu Arg Met Gln Met Glu Ile Asp Gln Leu Arg
         700                 705                 710

 ggg agg cca cca tcc tcc tac tcc agg tct ctc cct ggc agt gcc ctg     2210
 Gly Arg Pro Pro Ser Ser Tyr Ser Arg Ser Leu Pro Gly Ser Ala Leu
     715                 720                 725

 gag ctc cgt tac tct cag gca ccc act tta cct tct ggt gcc cac ctg     2258
 Glu Leu Arg Tyr Ser Gln Ala Pro Thr Leu Pro Ser Gly Ala His Leu
 730                 735                 740                 745

 gat ccc tat gtg gct ggc agt ggt cgg gca ggc aag agg ggc cgc tgg     2306
 Asp Pro Tyr Val Ala Gly Ser Gly Arg Ala Gly Lys Arg Gly Arg Trp
                 750                 755                 760

 tca ggg gtc aag gag gag ccc tcc aag gat tgg gag cgg tct gcc cct     2354
 Ser Gly Val Lys Glu Glu Pro Ser Lys Asp Trp Glu Arg Ser Ala Pro
             765                 770                 775

 tcg ggc tcc ata cca ccc cca ttc cct ggg gaa ctg gac ggc tcc gat     2402
 Ser Gly Ser Ile Pro Pro Pro Phe Pro Gly Glu Leu Asp Gly Ser Asp
         780                 785                 790

 gag gag gag gca gag ggg atg ttt ggg gcc gag ctg ctg tcc ccc agt     2450
 Glu Glu Glu Ala Glu Gly Met Phe Gly Ala Glu Leu Leu Ser Pro Ser
     795                 800                 805

 ggg cag gct gac gtg cag acg ctg gcc atc atg ctt cag gag cag ctg     2498
 Gly Gln Ala Asp Val Gln Thr Leu Ala Ile Met Leu Gln Glu Gln Leu
 810                 815                 820                 825

 gag gcc atc aac aag gag atc aag ctg atc caa gag gag aag gag aca     2546
 Glu Ala Ile Asn Lys Glu Ile Lys Leu Ile Gln Glu Glu Lys Glu Thr
                 830                 835                 840

 aca gaa cag agg gca gag gag ctg gag agt cgg gtg tcc agc tct ggc     2594
 Thr Glu Gln Arg Ala Glu Glu Leu Glu Ser Arg Val Ser Ser Ser Gly
             845                 850                 855

 ttg gac tcg ttg ggc cgc tac cgc agc agc tgc tcc ctg ccc ccc tcc     2642
 Leu Asp Ser Leu Gly Arg Tyr Arg Ser Ser Cys Ser Leu Pro Pro Ser
         860                 865                 870

 ctc acc acc tct acc ctt gcc agc ccc tcc cct ccc agc tct ggc cac     2690
 Leu Thr Thr Ser Thr Leu Ala Ser Pro Ser Pro Pro Ser Ser Gly His
     875                 880                 885

 tca aca ccc cgc ctg gca ccc cct agc cct gcc cgt gag ggc acc gac     2738
 Ser Thr Pro Arg Leu Ala Pro Pro Ser Pro Ala Arg Glu Gly Thr Asp
 890                 895                 900                 905

 aag gct aat cat gtc cct aag gag gaa gct gga gct cca cga ggg gag     2786
 Lys Ala Asn His Val Pro Lys Glu Glu Ala Gly Ala Pro Arg Gly Glu
                 910                 915                 920

 ggg ccg gcc atc cca gga gac acc cca cca ccc act ccc cgc tct gcc     2834
 Gly Pro Ala Ile Pro Gly Asp Thr Pro Pro Pro Thr Pro Arg Ser Ala
             925                 930                 935

 cgt ctt gag aga atg acc cag gcc ttg gca ctg cag gcg ggg tcc ctg     2882
 Arg Leu Glu Arg Met Thr Gln Ala Leu Ala Leu Gln Ala Gly Ser Leu
         940                 945                 950

 gaa gat ggg gga ccc cca cgg gga agt gag ggc acc cca gat tct ctg     2930
 Glu Asp Gly Gly Pro Pro Arg Gly Ser Glu Gly Thr Pro Asp Ser Leu
     955                 960                 965

 cac aaa gcc ccc aag aag aag agc atc aag tca tcc ata ggc cgt ctc     2978
 His Lys Ala Pro Lys Lys Lys Ser Ile Lys Ser Ser Ile Gly Arg Leu
 970                 975                 980                 985

 ttt ggc aag aaa gag aag gga cga atg gga ccc cca ggc cgg gac agc     3026
 Phe Gly Lys Lys Glu Lys Gly Arg Met Gly Pro Pro Gly Arg Asp Ser
                 990                 995                1000

 tct tct ctg gct gga aca ccc tca gat gag aca ctg gcc act gac cct     3074
 Ser Ser Leu Ala Gly Thr Pro Ser Asp Glu Thr Leu Ala Thr Asp Pro
            1005                1010                1015

 ctg ggg cta gcc aag ctg aca ggc cca gga gac aag gac cga agg aac     3122
 Leu Gly Leu Ala Lys Leu Thr Gly Pro Gly Asp Lys Asp Arg Arg Asn
        1020                1025                1030

 aag agg aag cat gaa ctc ctg gag gag gcc tgc cgc cag ggc cta cct     3170
 Lys Arg Lys His Glu Leu Leu Glu Glu Ala Cys Arg Gln Gly Leu Pro
    1035                1040                1045

 ttt gct gcc tgg gac ggg ccc acc gtg gtg tcc tgg ctg gag ctg tgg     3218
 Phe Ala Ala Trp Asp Gly Pro Thr Val Val Ser Trp Leu Glu Leu Trp
1050                1055                1060                1065

 gtg ggc atg cct gcc tgg tat gtg gcc gcc tgc cgg gcc aat gtc aag     3266
 Val Gly Met Pro Ala Trp Tyr Val Ala Ala Cys Arg Ala Asn Val Lys
                1070                1075                1080

 agc ggt gcc atc atg gcc aac ctg tca gac acg aag atc cag cgc gag     3314
 Ser Gly Ala Ile Met Ala Asn Leu Ser Asp Thr Lys Ile Gln Arg Glu
            1085                1090                1095

 atc ggc atc agc aac ccg ctg cac cga ctc aag cta cgc ctc gcc atc     3362
 Ile Gly Ile Ser Asn Pro Leu His Arg Leu Lys Leu Arg Leu Ala Ile
        1100                1105                1110

 cag gag atg gtc tcg ctc acc tcg ccc tca gcc ccc gcc tcc tcc cgc     3410
 Gln Glu Met Val Ser Leu Thr Ser Pro Ser Ala Pro Ala Ser Ser Arg
    1115                1120                1125

 act tcc aca gga aac gtg tgg atg aca cac gag gag atg gag tcc ctt     3458
 Thr Ser Thr Gly Asn Val Trp Met Thr His Glu Glu Met Glu Ser Leu
1130                1135                1140                1145

 acg gcc acg acc aag ccc gag acc aag gag atc agc tgg gag cag atc     3506
 Thr Ala Thr Thr Lys Pro Glu Thr Lys Glu Ile Ser Trp Glu Gln Ile
                1150                1155                1160

 ctg gca tat ggc gac atg aac cac gag tgg gtg ggg aac gac tgg ctg     3554
 Leu Ala Tyr Gly Asp Met Asn His Glu Trp Val Gly Asn Asp Trp Leu
            1165                1170                1175

 ccc agc ctg ggg ctg ccc caa tac cgc agc tac ttc atg gag tcg ctg     3602
 Pro Ser Leu Gly Leu Pro Gln Tyr Arg Ser Tyr Phe Met Glu Ser Leu
        1180                1185                1190

 gtg gac gct cga atg tta gat cac ctt aac aag aag gag ctc cgg ggc     3650
 Val Asp Ala Arg Met Leu Asp His Leu Asn Lys Lys Glu Leu Arg Gly
    1195                1200                1205

 caa ctc aag atg gtg gac agc ttt cac agg gtg agt cta cat tat ggg     3698
 Gln Leu Lys Met Val Asp Ser Phe His Arg Val Ser Leu His Tyr Gly
1210                1215                1220                1225

 att atg tgc ctg aaa cgg ctc aac tat gac cgg aag gac ctg gag cgg     3746
 Ile Met Cys Leu Lys Arg Leu Asn Tyr Asp Arg Lys Asp Leu Glu Arg
                1230                1235                1240

 agg cgg gaa gaa agt cag acc cag atc cga gac gtg atg gtg tgg tcc     3794
 Arg Arg Glu Glu Ser Gln Thr Gln Ile Arg Asp Val Met Val Trp Ser
            1245                1250                1255

 aat gag cgg gtc atg ggt tgg gtg tcc ggg ctg ggc ctg aag gaa ttt     3842
 Asn Glu Arg Val Met Gly Trp Val Ser Gly Leu Gly Leu Lys Glu Phe
        1260                1265                1270

 gcc acg aac ctc acg gag agc ggg gta cac ggg gca ctg ctc gcc ctg     3890
 Ala Thr Asn Leu Thr Glu Ser Gly Val His Gly Ala Leu Leu Ala Leu
    1275                1280                1285

 gac gag acc ttc gac tac tcc gac ctg gcc ttg ctc ctg cag atc ccc     3938
 Asp Glu Thr Phe Asp Tyr Ser Asp Leu Ala Leu Leu Leu Gln Ile Pro
1290                1295                1300                1305

 acg cag aat gca cag gcc cgg cag ctt ctg gag aag gaa ttc agc aac     3986
 Thr Gln Asn Ala Gln Ala Arg Gln Leu Leu Glu Lys Glu Phe Ser Asn
                1310                1315                1320

 ctt atc tcc tta ggc aca gac agg cgg ctg gac gag gac agc gcc aag     4034
 Leu Ile Ser Leu Gly Thr Asp Arg Arg Leu Asp Glu Asp Ser Ala Lys
            1325                1330                1335

 tct ttc agc cgc tcc cca tcc tgg cgg aag atg ttc cgg gag aag gac     4082
 Ser Phe Ser Arg Ser Pro Ser Trp Arg Lys Met Phe Arg Glu Lys Asp
        1340                1345                1350

 ctc cga ggc gta act ccc gac tca gct gag atg ttg ccc ccc aac ttt     4130
 Leu Arg Gly Val Thr Pro Asp Ser Ala Glu Met Leu Pro Pro Asn Phe
    1355                1360                1365

 cgt tcg gct gca gcg gga gcc ctg ggc tct ccg ggg ctc cct ctc cgc     4178
 Arg Ser Ala Ala Ala Gly Ala Leu Gly Ser Pro Gly Leu Pro Leu Arg
1370                1375                1380                1385

 aag ctg cag cca gaa ggc cag act tct ggg agt tcc cgg gca gac ggc     4226
 Lys Leu Gln Pro Glu Gly Gln Thr Ser Gly Ser Ser Arg Ala Asp Gly
                1390                1395                1400

 gtt tcg gtc cgg acc tat tcc tgc tag tgcag gcctccaggt gacctcactc     4278
 Val Ser Val Arg Thr Tyr Ser Cys 
            1405

 ggacggaaga atcttcccga ggctgggctg ttccctctcc tgcccggact gtggcctcgc   4338

 cggggagagc gggcggggga gctcgcgccg aggactggac catctgtaca gaccagcggg   4398

 agtgcgcgcg cccgcctcgc acagggccgg ggcctggacc aaaccacatg aactggactg   4458

 agagggggaa gaagcgggga ggaagaaatc ccgccccaaa cgtccgcttt ccttttctct   4518

 actttgtaat ttattgatca gtttctgttg ggagacgggt gtcctttacc cgcgggaagg   4578

 gggcggggct tccctcccgg gccgcatgcg gggagaggct gctccctccc ctttttcctg   4638

 cccagtcgcg gggcccaagt cttccttctt cgtccgaaag gaggggaggg gggactcgct   4698

 gctacaagcc tcgccccctg tgccactcag ctccgccccg ccgcgtccgg tcgccggtcc   4758

 cccgggtcat ctgcgggcgg ggtcccctct ccctcccccg tgtctcgtgt ccccggggcc   4818

 tcaccgcccc ccgtgctgtg gccgtgtccg tgccccgggg gtagggggcg cagaatggcg   4878

 cttccccttc tcctctggct ccggggtttg catgggagaa tcctctttcc acgatgccgc   4938

 tgggcgacgt ggcgtggggg cagggggacg gtgggggagc cctcgccccc gactctcggt   4998

 cggcctcccc gccccaggcg tcactcagtg atcacgggta aagagaactg tttcaaaaaa   5058

 aaaaaa                                                              5064




      <210> 223
      <211> 3410
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(2437)

      <400> 223
 ggacgggcat ctggaatcgc tgcctctggc tttctgtttt ctactaacag gatttggtca     60

 ctggttcttc atcttttgtc tgttgcacgc atcccgccct ccccacttgc ttccccactc    120

 cttggatcca gccctgtggg cattcacgtc agttctctga ccccgccgtg agccccgctc    180

 cgggtccccg ggcgggcttg gcacggaggc ggtaact atg gag aat atg gcg gag     235
                                          Met Glu Asn Met Ala Glu
                                            1               5

 gag gag ctg ctg ccc ctg gag aag gag gag gtg gag gtg gcc cag gtc      283
 Glu Glu Leu Leu Pro Leu Glu Lys Glu Glu Val Glu Val Ala Gln Val
              10                  15                  20

 cag gtc ccg acc ccg gcc cgg gac tcg gct ggg gtc cca gct ccg gcc      331
 Gln Val Pro Thr Pro Ala Arg Asp Ser Ala Gly Val Pro Ala Pro Ala
          25                  30                  35

 ccg gat tcg gct ctg gac tcg gct ccg act ccg gcc tcg gct cca gcc      379
 Pro Asp Ser Ala Leu Asp Ser Ala Pro Thr Pro Ala Ser Ala Pro Ala
      40                  45                  50

 cca gcc cct gcc ctg gcc cag gct ccg gcc ctg tcc ccg tcc cta gcc      427
 Pro Ala Pro Ala Leu Ala Gln Ala Pro Ala Leu Ser Pro Ser Leu Ala
  55                  60                  65                  70

 tct gcc cct gag gag gct aaa agc aag aga cac atc tca att caa agg      475
 Ser Ala Pro Glu Glu Ala Lys Ser Lys Arg His Ile Ser Ile Gln Arg
                  75                  80                  85

 cag ctt gct gat cta gag aat tta gct ttt gta act gat gga aat ttt      523
 Gln Leu Ala Asp Leu Glu Asn Leu Ala Phe Val Thr Asp Gly Asn Phe
              90                  95                 100

 gac tct gcc agc tca ttg aac tca gat aat ctt gat gca ggc aac aga      571
 Asp Ser Ala Ser Ser Leu Asn Ser Asp Asn Leu Asp Ala Gly Asn Arg
         105                 110                 115

 cag gct tgt cca ttg tgc cct aag gaa aaa ttc aga gct tgt aat agc      619
 Gln Ala Cys Pro Leu Cys Pro Lys Glu Lys Phe Arg Ala Cys Asn Ser
     120                 125                 130

 cat aag ctt cgt cgt cac ctc cag aat tta cac tgg aaa gtc tca gtt      667
 His Lys Leu Arg Arg His Leu Gln Asn Leu His Trp Lys Val Ser Val
 135                 140                 145                 150

 gaa ttt gaa ggt tac agg atg tgc atc tgt cac tta cct tgt cga cca      715
 Glu Phe Glu Gly Tyr Arg Met Cys Ile Cys His Leu Pro Cys Arg Pro
                 155                 160                 165

 gtg aaa cca aac att att gga gaa cag ata acc agt aaa atg gga gcc      763
 Val Lys Pro Asn Ile Ile Gly Glu Gln Ile Thr Ser Lys Met Gly Ala
             170                 175                 180

 cat tat cat tgt atc att tgt tca gca aca atc acc aga aga act gat      811
 His Tyr His Cys Ile Ile Cys Ser Ala Thr Ile Thr Arg Arg Thr Asp
         185                 190                 195

 atg cta gga cat gtt agg cgc cac atg aat aaa gga gag act aaa tct      859
 Met Leu Gly His Val Arg Arg His Met Asn Lys Gly Glu Thr Lys Ser
     200                 205                 210

 agt tat att gca gct tcc act gct aaa cca cct aag gaa att ttg aaa      907
 Ser Tyr Ile Ala Ala Ser Thr Ala Lys Pro Pro Lys Glu Ile Leu Lys
 215                 220                 225                 230

 gag gca gac acg gat gta caa gtt tgt ccc aac tat tct ata cct cag      955
 Glu Ala Asp Thr Asp Val Gln Val Cys Pro Asn Tyr Ser Ile Pro Gln
                 235                 240                 245

 aaa aca gat tcc tat ttt aac ccc aaa atg aaa cta aat cgg cag cta     1003
 Lys Thr Asp Ser Tyr Phe Asn Pro Lys Met Lys Leu Asn Arg Gln Leu
             250                 255                 260

 ata ttc tgt aca ttg gct gct ttg gct gag gaa cga aaa cct ttg gaa     1051
 Ile Phe Cys Thr Leu Ala Ala Leu Ala Glu Glu Arg Lys Pro Leu Glu
         265                 270                 275

 tgt cta gat gct ttt gga gcc act ggg ata atg gga tta cag tgg gca     1099
 Cys Leu Asp Ala Phe Gly Ala Thr Gly Ile Met Gly Leu Gln Trp Ala
     280                 285                 290

 aaa cat ctt gga aat gca gtc aaa gtt aca atc aat gac ttg aat gaa     1147
 Lys His Leu Gly Asn Ala Val Lys Val Thr Ile Asn Asp Leu Asn Glu
 295                 300                 305                 310

 aat tct gtg aca ctg att cag gaa aac tgc cat tta aac aaa ttg aaa     1195
 Asn Ser Val Thr Leu Ile Gln Glu Asn Cys His Leu Asn Lys Leu Lys
                 315                 320                 325

 gtg gtg gtg gac agt aag gaa aag gaa aag agt gat gat att ctt gaa     1243
 Val Val Val Asp Ser Lys Glu Lys Glu Lys Ser Asp Asp Ile Leu Glu
             330                 335                 340

 gaa gga gag aaa aat ctt ggt aat att aag gtg acc aaa atg gat gcc     1291
 Glu Gly Glu Lys Asn Leu Gly Asn Ile Lys Val Thr Lys Met Asp Ala
         345                 350                 355

 aat gta ctg atg cat ttg aga tct ttt gat ttc ata cat cta gac cct     1339
 Asn Val Leu Met His Leu Arg Ser Phe Asp Phe Ile His Leu Asp Pro
     360                 365                 370

 ttt gga aca tca gtg aat tat cta gat tct gca ttc aga aat ata aga     1387
 Phe Gly Thr Ser Val Asn Tyr Leu Asp Ser Ala Phe Arg Asn Ile Arg
 375                 380                 385                 390

 aac ctt ggc ata gtg tca gtg act tct aca gat atc agt tct tta tat     1435
 Asn Leu Gly Ile Val Ser Val Thr Ser Thr Asp Ile Ser Ser Leu Tyr
                 395                 400                 405

 gcc aag gca cag cat gtt gcc cgg cgt cac tac gga tgt aac att gtc     1483
 Ala Lys Ala Gln His Val Ala Arg Arg His Tyr Gly Cys Asn Ile Val
             410                 415                 420

 cga act gaa tat tac aag gaa cta gca gcc aga att gtt gta gct gca     1531
 Arg Thr Glu Tyr Tyr Lys Glu Leu Ala Ala Arg Ile Val Val Ala Ala
         425                 430                 435

 gtg gca agg tac caa att gcc aac agt gta ctt acc cga tgc aac aaa     1579
 Val Ala Arg Tyr Gln Ile Ala Asn Ser Val Leu Thr Arg Cys Asn Lys
     440                 445                 450

 ggc ata gaa gta ctg ttt gca gtg gct ctg gaa cat ttt gtg ttg gta     1627
 Gly Ile Glu Val Leu Phe Ala Val Ala Leu Glu His Phe Val Leu Val
 455                 460                 465                 470

 gtt gtg aga gtt ttg agg gga cct act tca gca gat gaa aca gcc aag     1675
 Val Val Arg Val Leu Arg Gly Pro Thr Ser Ala Asp Glu Thr Ala Lys
                 475                 480                 485

 aag att caa tac ctg atc cat tgt cag tgg tgt gaa gag aga att ttt     1723
 Lys Ile Gln Tyr Leu Ile His Cys Gln Trp Cys Glu Glu Arg Ile Phe
             490                 495                 500

 cag aag gat ggt aat atg gta gaa gaa aac cca tat aga cag ctg cct     1771
 Gln Lys Asp Gly Asn Met Val Glu Glu Asn Pro Tyr Arg Gln Leu Pro
         505                 510                 515

 tgt aac tgt cat gga agc atg cct gga aag aca gca ata gaa ctt gga     1819
 Cys Asn Cys His Gly Ser Met Pro Gly Lys Thr Ala Ile Glu Leu Gly
     520                 525                 530

 cct ctg tgg tca agt tcc ctt ttc aat act gga ttc ctc aaa aga atg     1867
 Pro Leu Trp Ser Ser Ser Leu Phe Asn Thr Gly Phe Leu Lys Arg Met
 535                 540                 545                 550

 cta ttt gaa tct ctt cac cat ggt ttg gat gac att cag acc cta ata     1915
 Leu Phe Glu Ser Leu His His Gly Leu Asp Asp Ile Gln Thr Leu Ile
                 555                 560                 565

 aag aca tta atc ttt gaa tca gag tgt acg cct caa agt cag ttt tca     1963
 Lys Thr Leu Ile Phe Glu Ser Glu Cys Thr Pro Gln Ser Gln Phe Ser
             570                 575                 580

 att cat gca tct tca aat gtc aac aag caa gaa gaa aat ggt gta ttt     2011
 Ile His Ala Ser Ser Asn Val Asn Lys Gln Glu Glu Asn Gly Val Phe
         585                 590                 595

 att aaa act aca gat gac acc aca aca gat aat tac att gca caa gga     2059
 Ile Lys Thr Thr Asp Asp Thr Thr Thr Asp Asn Tyr Ile Ala Gln Gly
     600                 605                 610

 aag aga aaa agt aat gaa atg atc aca aat tta ggc aag aag caa aag     2107
 Lys Arg Lys Ser Asn Glu Met Ile Thr Asn Leu Gly Lys Lys Gln Lys
 615                 620                 625                 630

 act gat gtc agt act gaa cat cct ccc ttt tat tac aac att cac aga     2155
 Thr Asp Val Ser Thr Glu His Pro Pro Phe Tyr Tyr Asn Ile His Arg
                 635                 640                 645

 cac agc att aaa gga atg aat atg cca aag tta aaa aag ttt ttg tgc     2203
 His Ser Ile Lys Gly Met Asn Met Pro Lys Leu Lys Lys Phe Leu Cys
             650                 655                 660

 tat tta tct caa gca ggc ttt cga gta agc cga act cat ttt gac cca     2251
 Tyr Leu Ser Gln Ala Gly Phe Arg Val Ser Arg Thr His Phe Asp Pro
         665                 670                 675

 atg ggt gta cgc aca gat gca cct ctg atg cag ttt aaa tct atc ctt     2299
 Met Gly Val Arg Thr Asp Ala Pro Leu Met Gln Phe Lys Ser Ile Leu
     680                 685                 690

 tta aag tac agc acc ccc acc tac act gga gga cag tca gaa agc cat     2347
 Leu Lys Tyr Ser Thr Pro Thr Tyr Thr Gly Gly Gln Ser Glu Ser His
 695                 700                 705                 710

 gtc cag tca gca tct gaa gat aca gta act gaa aga gtt gaa atg tca     2395
 Val Gln Ser Ala Ser Glu Asp Thr Val Thr Glu Arg Val Glu Met Ser
                 715                 720                 725

 gtg aat gac aaa gca gaa gca agt ggc tgc aga aga tgg taa acgtaga     2444
 Val Asn Asp Lys Ala Glu Ala Ser Gly Cys Arg Arg Trp 
             730                 735

 gaagaattgg ttctcaggtg tctgtataga tggcctaata gttctctata ccaactgtag   2504

 ttctttttct gttctttcaa ttcagtagag taaaaataaa aaacagtgtc attttcattc   2564

 agaaactgag cagtttctaa cttagctggt ttgggagctt tgctttccaa gttttttttt   2624

 gttttaaggc aaacttaaaa ttttaatgga aacatttcat atgaagccaa gtctcactga   2684

 gatcacccta ctgcttaata attcagaaaa ttttcacatg caaagtgttt ggaattttat   2744

 gtatgttatg aaagccatct tttacaattc ttaatcacat ctctgcctaa actgattcat   2804

 gatgtttatg ttttcctgtt tgtagtgtac aaaatgaagc tgaaggctca catgttaaaa   2864

 tgaccctgaa tagaatagga agaacaatgt tcttacaggt cataatgtat ttcacaatta   2924

 aaaaactaaa atatgtaccc atttttaaga aatcatactt ctctccacat tgatcttttc   2984

 atttcttact agcttttaag aaattaaata cttgcctgag atagaaatac tttatttttg   3044

 taactttaag gtctaaatga ctaaacttca aagtaagatt ttgtcagaat aaattgagac   3104

 cattaatcta atataatact tgttcatgag cactgaaatc ctgaagagga gagatttggt   3164

 tataaattaa aaaggttggg tgatcttaag tgcctcagtt aatgcacgta cagtattcat   3224

 ttggttggtt gtactacctc tcagaagtaa aatttgtcac cttatggaat gagagttttt   3284

 gggtttgggg gttgtttttt tgttgttgct tggtttggta tttttggttt tgtgtgtatt   3344

 tgtataaatt ttctgtataa ttagcccagg ctgatgtaac tataaaaatt agttgaaaaa   3404

 aaaaaa                                                              3410




      <210> 224
      <211> 3137
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (293)..(2584)

      <400> 224
 cgccgcccga cagcgcgccc ggaacatgcc agcctcgcgc agcctgcgct gacttccccg     60

 agacgcgccg cggtcggcac ggagactttc tgggctctgg atggttcgtg cgctgctcac    120

 cctcgcccac ccctgacgcc gcggaccgca gctcctcagc cccgcagccc cgcagccccg    180

 cagcccagca gccccgcagc ggcgccgagg acagtgcagc cgagttgcgt ctccctcgcg    240

 cgagcagcca ttgtttgatg tcctgtgact gagaaaccag gctttaaact tt    atg     295
                                                              Met
                                                                1

 cct ttg gag atg gag ccc aag atg agc aaa ctg gcc ttt ggc tgt cag      343
 Pro Leu Glu Met Glu Pro Lys Met Ser Lys Leu Ala Phe Gly Cys Gln
               5                  10                  15

 aga agt tcc aca tca gat gat gac tct ggc tgt gca ttg gag gag tac      391
 Arg Ser Ser Thr Ser Asp Asp Asp Ser Gly Cys Ala Leu Glu Glu Tyr
          20                  25                  30

 gcc tgg gtc ccc ccg ggc ctg aga cca gag cag atc cag ctc tat ttt      439
 Ala Trp Val Pro Pro Gly Leu Arg Pro Glu Gln Ile Gln Leu Tyr Phe
      35                  40                  45

 gct tgc tta cca gag gaa aaa gtt cct tac gtt aac agc ccc gga gag      487
 Ala Cys Leu Pro Glu Glu Lys Val Pro Tyr Val Asn Ser Pro Gly Glu
  50                  55                  60                  65

 aag cat cgg att aaa cag ctt ttg tac cag tta cca cca cat gat aat      535
 Lys His Arg Ile Lys Gln Leu Leu Tyr Gln Leu Pro Pro His Asp Asn
                  70                  75                  80

 gag gta cgg tat tgc cag tct ttg agt gaa gag gag aaa aaa gag ttg      583
 Glu Val Arg Tyr Cys Gln Ser Leu Ser Glu Glu Glu Lys Lys Glu Leu
              85                  90                  95

 cag gtg ttc agt gct cag cgg aag aaa gaa gca ctg gga aga gga aca      631
 Gln Val Phe Ser Ala Gln Arg Lys Lys Glu Ala Leu Gly Arg Gly Thr
         100                 105                 110

 att aag ctt ctg tcc aga gca gtc atg cat gct gtg tgt gag cag ata      679
 Ile Lys Leu Leu Ser Arg Ala Val Met His Ala Val Cys Glu Gln Ile
     115                 120                 125

 att ttt gct gat gag tgc aca gaa gct gag ggt cgc cat tgg cac atg      727
 Ile Phe Ala Asp Glu Cys Thr Glu Ala Glu Gly Arg His Trp His Met
 130                 135                 140                 145

 aaa cac ttc tgc tgc ctt gag tgt gaa acg gtc ctg gga gga cag agg      775
 Lys His Phe Cys Cys Leu Glu Cys Glu Thr Val Leu Gly Gly Gln Arg
                 150                 155                 160

 tat atc atg aag gac ggc cgc ccc ttc tgc tgt ggc tgt ttt gag tct      823
 Tyr Ile Met Lys Asp Gly Arg Pro Phe Cys Cys Gly Cys Phe Glu Ser
             165                 170                 175

 ctc tat gcg gag tac tgt gaa acc tgt ggg gaa cat att ggt gtg gac      871
 Leu Tyr Ala Glu Tyr Cys Glu Thr Cys Gly Glu His Ile Gly Val Asp
         180                 185                 190

 cat gca cag atg acc tat gac ggg cag cac tgg cac gcc acg gaa gcc      919
 His Ala Gln Met Thr Tyr Asp Gly Gln His Trp His Ala Thr Glu Ala
     195                 200                 205

 tgc ttt tct tgt gcc cag tgt aaa gcc tct ttg ttg gga tgt ccc ttc      967
 Cys Phe Ser Cys Ala Gln Cys Lys Ala Ser Leu Leu Gly Cys Pro Phe
 210                 215                 220                 225

 ctt ccc aaa cag ggt cag att tac tgc tca aaa acg tgc agt ctt ggt     1015
 Leu Pro Lys Gln Gly Gln Ile Tyr Cys Ser Lys Thr Cys Ser Leu Gly
                 230                 235                 240

 gaa gac gtc cat gcc tct gat tct tcc gac tct gca ttt cag tca gct     1063
 Glu Asp Val His Ala Ser Asp Ser Ser Asp Ser Ala Phe Gln Ser Ala
             245                 250                 255

 cga tca aga gac tcc cga aga agt gtc cga atg ggc aag agc agc cgg     1111
 Arg Ser Arg Asp Ser Arg Arg Ser Val Arg Met Gly Lys Ser Ser Arg
         260                 265                 270

 tca gca gat cag tgt aga cag tct ctc ctc tta tcg cct gct ctg aac     1159
 Ser Ala Asp Gln Cys Arg Gln Ser Leu Leu Leu Ser Pro Ala Leu Asn
     275                 280                 285

 tac aag ttt cct ggc ctc tca ggc aat gct gat gac acc ctt tct cga     1207
 Tyr Lys Phe Pro Gly Leu Ser Gly Asn Ala Asp Asp Thr Leu Ser Arg
 290                 295                 300                 305

 aaa ttg gat gat ctg agt ctc tcc aga caa gga aca agt ttt gcc agt     1255
 Lys Leu Asp Asp Leu Ser Leu Ser Arg Gln Gly Thr Ser Phe Ala Ser
                 310                 315                 320

 gaa gaa ttt tgg aaa ggc aga gta gag cag gaa act cca gaa gac cct     1303
 Glu Glu Phe Trp Lys Gly Arg Val Glu Gln Glu Thr Pro Glu Asp Pro
             325                 330                 335

 gaa gaa tgg gct gat cat gaa gat tat atg acg cag ctc ctc ctc aag     1351
 Glu Glu Trp Ala Asp His Glu Asp Tyr Met Thr Gln Leu Leu Leu Lys
         340                 345                 350

 ttt ggt gat aaa agc ctc ttt cag cca cag ccc aat gag atg gat att     1399
 Phe Gly Asp Lys Ser Leu Phe Gln Pro Gln Pro Asn Glu Met Asp Ile
     355                 360                 365

 cga gcc agt gag cac tgg ata tct gat aac atg gtt aaa agt aag acc     1447
 Arg Ala Ser Glu His Trp Ile Ser Asp Asn Met Val Lys Ser Lys Thr
 370                 375                 380                 385

 gag tta aag caa aat aac cag agc ctt gca agt aaa aaa tac cag tct     1495
 Glu Leu Lys Gln Asn Asn Gln Ser Leu Ala Ser Lys Lys Tyr Gln Ser
                 390                 395                 400

 gat atg tac tgg gca cag tca caa gat gga ctg ggc gat tct gct tat     1543
 Asp Met Tyr Trp Ala Gln Ser Gln Asp Gly Leu Gly Asp Ser Ala Tyr
             405                 410                 415

 ggc agc cac cca ggc cct gca agc agt aga agg ctt cag gaa ttg gaa     1591
 Gly Ser His Pro Gly Pro Ala Ser Ser Arg Arg Leu Gln Glu Leu Glu
         420                 425                 430

 ctg gac cat ggg gct tca ggg tat aat cat gat gaa aca cag tgg tat     1639
 Leu Asp His Gly Ala Ser Gly Tyr Asn His Asp Glu Thr Gln Trp Tyr
     435                 440                 445

 gaa gat tcc ctg gag tgt ctg tca gac ctg aaa cca gag caa agt gtt     1687
 Glu Asp Ser Leu Glu Cys Leu Ser Asp Leu Lys Pro Glu Gln Ser Val
 450                 455                 460                 465

 cgg gat tcg atg gat tct ttg gca ttg tcc aat atc aca ggg gct tcg     1735
 Arg Asp Ser Met Asp Ser Leu Ala Leu Ser Asn Ile Thr Gly Ala Ser
                 470                 475                 480

 gtg gat gga gaa aac aag cca agg cca tca ttg tat tct ctg caa aat     1783
 Val Asp Gly Glu Asn Lys Pro Arg Pro Ser Leu Tyr Ser Leu Gln Asn
             485                 490                 495

 ttt gag gag atg gaa aca gaa gat tgt gag aag atg agc aat atg gga     1831
 Phe Glu Glu Met Glu Thr Glu Asp Cys Glu Lys Met Ser Asn Met Gly
         500                 505                 510

 act ttg aac tct tcc atg ctg cac agg agt gca gag tcc tta aag agt     1879
 Thr Leu Asn Ser Ser Met Leu His Arg Ser Ala Glu Ser Leu Lys Ser
     515                 520                 525

 cta agt tca gag ttg tgt cca gag aaa atc ctg cct gaa gag aag cca     1927
 Leu Ser Ser Glu Leu Cys Pro Glu Lys Ile Leu Pro Glu Glu Lys Pro
 530                 535                 540                 545

 gta cat ctg cca gtg ctc aga agg tcc aag tct caa tcc aga ccc cag     1975
 Val His Leu Pro Val Leu Arg Arg Ser Lys Ser Gln Ser Arg Pro Gln
                 550                 555                 560

 cag gtc aag ttt tcc gat gat gtc att gac aat ggg aac tat gac att     2023
 Gln Val Lys Phe Ser Asp Asp Val Ile Asp Asn Gly Asn Tyr Asp Ile
             565                 570                 575

 gaa atc cgg cag cct ccg atg agt gaa agg act cgg aga cgc gtc tac     2071
 Glu Ile Arg Gln Pro Pro Met Ser Glu Arg Thr Arg Arg Arg Val Tyr
         580                 585                 590

 aat ttt gaa gag agg gga tcc agg tct cat cac cac cgc cgc cgg aga     2119
 Asn Phe Glu Glu Arg Gly Ser Arg Ser His His His Arg Arg Arg Arg
     595                 600                 605

 agt aga aag tcc cgc tcc gac aat gcc ctg aat ctt gtt aca gaa aga     2167
 Ser Arg Lys Ser Arg Ser Asp Asn Ala Leu Asn Leu Val Thr Glu Arg
 610                 615                 620                 625

 aaa tac tct ccc aag gac aga ctg cgg ctg tac acc ccc gat aac tat     2215
 Lys Tyr Ser Pro Lys Asp Arg Leu Arg Leu Tyr Thr Pro Asp Asn Tyr
                 630                 635                 640

 gag aaa ttt ata cag aat aaa agt gcc cgg gag atc caa gca tac atc     2263
 Glu Lys Phe Ile Gln Asn Lys Ser Ala Arg Glu Ile Gln Ala Tyr Ile
             645                 650                 655

 cag aat gct gat ctc tac gga cag tac gcc cat gcc act tcc gat tat     2311
 Gln Asn Ala Asp Leu Tyr Gly Gln Tyr Ala His Ala Thr Ser Asp Tyr
         660                 665                 670

 ggc ctg cag aac cca gga atg aat cgg ttt ctg gga ctc tac ggc gag     2359
 Gly Leu Gln Asn Pro Gly Met Asn Arg Phe Leu Gly Leu Tyr Gly Glu
     675                 680                 685

 gat gat gat tcc tgg tgt tct tcc tcc tcc tcc tct tcc gac tcg gaa     2407
 Asp Asp Asp Ser Trp Cys Ser Ser Ser Ser Ser Ser Ser Asp Ser Glu
 690                 695                 700                 705

 gaa gaa gga tat ttt ctt gga caa cca atc cct caa ccc cgg cca cag     2455
 Glu Glu Gly Tyr Phe Leu Gly Gln Pro Ile Pro Gln Pro Arg Pro Gln
                 710                 715                 720

 aga ttt gcc tac tat aca gat gac ctt tct agt cca cca tct gca ctt     2503
 Arg Phe Ala Tyr Tyr Thr Asp Asp Leu Ser Ser Pro Pro Ser Ala Leu
             725                 730                 735

 ccc acc cct cag ttt ggt cag agg aca aca aaa tcc aag aag aaa aag     2551
 Pro Thr Pro Gln Phe Gly Gln Arg Thr Thr Lys Ser Lys Lys Lys Lys
         740                 745                 750

 gga cac aag ggc aaa aat tgt att att tct taa ccaagtag tgatgcagag     2602
 Gly His Lys Gly Lys Asn Cys Ile Ile Ser 
     755                 760

 catttgttta aaacttagcc attaaccgtc tgaatcgttt ccttttcttc cgtaggaaag   2662

 ttgtgaaaat agcttaaagt gctttctttg cccatgtaaa tgagaactca actgctgttt   2722

 acagtgtcag attaacattt gaaaggtgtg atttctccaa tttaccctct ttggatggtg   2782

 ccaggtggac gtgacatctc gtgcctgtcc ggtgcgggtg cgttacagat ggacgtagct   2842

 gctttggttt tccagtcctc aagggaatac tgaagatgct gactgaaggg gattggatgt   2902

 tgattttaga agatggagaa ctccagccac ctttgtaaag cactagtgtt tgtcatttat   2962

 gtaagtcagg tcggctcagg tcttgatagt ccgtcttggt gtgaggcatg cctgtcacga   3022

 tgacctagct aacactgtgc atcttattgt gaggccagct tgtcccctcg aaccctcttt   3082

 ggccaggtaa acattgtatt gtatcagctc cagctacaga ttgaaaaaaa aaaaa        3137




      <210> 225
      <211> 1248
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (261)..(875)

      <220>
      <221> misc_feature
      <222> (1)...(1248)
      <223> n = a,t,c or g

      <400> 225
 aaggatcctt aattaaatta atcccccccc cccccccgag tcggaggcgg ccggctgggc     60

 gtgcgctcgc tccccgaagc cggggctggg ccggagccgg gcgagggctg ggagctgggc    120

 cgggtccggg gacagcgggc gaggggcagc tgccggagcc gggcagccag gccgctcagg    180

 gcaggggaca gctggcgccg gttctgcggt ctccggggcc cagatgtgag gcggcggcgc    240

 ccccggcccg agagcgcacg    atg ggg gcc ccg ctc gcc gta gcg ctg ggc     290
                          Met Gly Ala Pro Leu Ala Val Ala Leu Gly
                            1               5                  10

 gcc ctc cac tac ctg gca ctt ttc ctg caa ctc ggc ggc gcc acg cgg      338
 Ala Leu His Tyr Leu Ala Leu Phe Leu Gln Leu Gly Gly Ala Thr Arg
                  15                  20                  25

 ccc gcc ggc cac gcg ccc tgg gac aac cac gtc tcc ggc cac gcc ctg      386
 Pro Ala Gly His Ala Pro Trp Asp Asn His Val Ser Gly His Ala Leu
              30                  35                  40

 ttc aca gag aca ccc cat gac atg aca gca cgg acg ggc gag gac gtg      434
 Phe Thr Glu Thr Pro His Asp Met Thr Ala Arg Thr Gly Glu Asp Val
          45                  50                  55

 gag atg gcc tgc tcc ttc cgc ggc agc ggc tcc ccc tcc tac tcg ctg      482
 Glu Met Ala Cys Ser Phe Arg Gly Ser Gly Ser Pro Ser Tyr Ser Leu
      60                  65                  70

 gag atc cag tgg tgg tat gta cgg agc cac cgg gac tgg acc gac aag      530
 Glu Ile Gln Trp Trp Tyr Val Arg Ser His Arg Asp Trp Thr Asp Lys
  75                  80                  85                  90

 cag gcg tgg gcc tcg aac cag cta aaa gca tct cag cag gaa gac gca      578
 Gln Ala Trp Ala Ser Asn Gln Leu Lys Ala Ser Gln Gln Glu Asp Ala
                  95                 100                 105

 ggg aag gag gca acc aaa ata agt gtg gtc aag gtg gtg ggc agc aac      626
 Gly Lys Glu Ala Thr Lys Ile Ser Val Val Lys Val Val Gly Ser Asn
             110                 115                 120

 atc tcc cac aag ctg cgc ctg tcc cgg gtg aag ccc acg gac gaa ggc      674
 Ile Ser His Lys Leu Arg Leu Ser Arg Val Lys Pro Thr Asp Glu Gly
         125                 130                 135

 acc tac gag tgc cgc gtc atc gac ttc agc gac ggc aag gcc cgg cac      722
 Thr Tyr Glu Cys Arg Val Ile Asp Phe Ser Asp Gly Lys Ala Arg His
     140                 145                 150

 cac aag gtc aag gcc tac ctg cgg gtg cag cca ggg gag aac tcc gtc      770
 His Lys Val Lys Ala Tyr Leu Arg Val Gln Pro Gly Glu Asn Ser Val
 155                 160                 165                 170

 ctg cat ctg ccc gaa gtc cct ccc gcc gcg gcc gcc acg ccg ccc ccc      818
 Leu His Leu Pro Glu Val Pro Pro Ala Ala Ala Ala Thr Pro Pro Pro
                 175                 180                 185

 aag cca ggc aag gag ctg agg aag cgc tcg gtg gac cag gag gcc tgc      866
 Lys Pro Gly Lys Glu Leu Arg Lys Arg Ser Val Asp Gln Glu Ala Cys
             190                 195                 200

 agc ctc tag acatgat gcccctggcc ccggccatcc gggcccacgc tgtacagagt      922
 Ser Leu 


 gcatgaggag ccgccggacc acgnnaagct gactgcctgc gtccagccgc gccccatccc    982

 cgaagctgcg tgtggcacca atgtcgggcc tctttccaac aaccctttgg tctagatgta   1042

 aggccccaac aacccttgcc tttcagaccc tgcggtgact tggttggaga gngtggcttg   1102

 gaacaagggg caaacggctt gacaatgggc aaggacatgc tgggcccggg caacccttct   1162

 ggtacagctc agtgggccca ggttttcttg gtagatttcc cacacccccg aaccagggcc   1222

 ccagggtgct ccctccctac actctt                                        1248




      <210> 226
      <211> 1017
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (254)..(970)

      <400> 226
 agaggcgttc ccgcgcccgg cagggtaggc gcagtgcgca ggcgcccaaa gccgacgtgg     60

 aggtgatgcg cgggagcaca gatccggggc agtgcgctgc gcagaggcgc gcggcgaagc    120

 cgagtgggcg cgggagtgac gtcacggcgc gcgacgcgga ggcggggtcg ggcctgggca    180

 actcgctgat ggcgccggta ggccgctggc agaagggccg cgacctcacc tggtacgcca    240

 agggccgggc gcc   atg cgc ggg ccc gag ccg cga gga gga act ggc agc     289
                  Met Arg Gly Pro Glu Pro Arg Gly Gly Thr Gly Ser
                    1               5                  10

 cgt gcg gga ggc gga gcg cga ggc gct gct ggc cgc cct tgg cta caa      337
 Arg Ala Gly Gly Gly Ala Arg Gly Ala Ala Gly Arg Pro Trp Leu Gln
          15                  20                  25

 gaa cgt gaa gaa gca gcc cac ggg cct gag caa gga gga ctt cgc gga      385
 Glu Arg Glu Glu Ala Ala His Gly Pro Glu Gln Gly Gly Leu Arg Gly
      30                  35                  40

 ggt ctg caa gcg gga agg agg cga ccc cga gga gaa ggg cgt gga ccg      433
 Gly Leu Gln Ala Gly Arg Arg Arg Pro Arg Gly Glu Gly Arg Gly Pro
  45                  50                  55                  60

 gct gct ggg gct ggg gag cgc aag gtg cgg gcg ggt ttc cag ggg agg      481
 Ala Ala Gly Ala Gly Glu Arg Lys Val Arg Ala Gly Phe Gln Gly Arg
                  65                  70                  75

 gca gca ctg ggc tcg att gct cgg gtg agg cgg acc cct gcc gta ctg      529
 Ala Ala Leu Gly Ser Ile Ala Arg Val Arg Arg Thr Pro Ala Val Leu
              80                  85                  90

 tct tca tcg cca tgt ccc tgc agt ggc tcc gtg ggc cgc gtg gcg atg      577
 Ser Ser Ser Pro Cys Pro Cys Ser Gly Ser Val Gly Arg Val Ala Met
          95                 100                 105

 tcc cga gag gac aag gag gcc gcc aaa ctg ggg ctg tct gtg ttc acg      625
 Ser Arg Glu Asp Lys Glu Ala Ala Lys Leu Gly Leu Ser Val Phe Thr
     110                 115                 120

 cat cac cgc gta gag agc ggc ggg ccc ggg acc tcg gca gcc tcg gcc      673
 His His Arg Val Glu Ser Gly Gly Pro Gly Thr Ser Ala Ala Ser Ala
 125                 130                 135                 140

 agg agg aag ccg cgg gcg gag gat cag acg gaa agc agt tgt gag agc      721
 Arg Arg Lys Pro Arg Ala Glu Asp Gln Thr Glu Ser Ser Cys Glu Ser
                 145                 150                 155

 cac agg aaa agc aag aag gag aag aag aaa aag aaa aag agg aaa cac      769
 His Arg Lys Ser Lys Lys Glu Lys Lys Lys Lys Lys Lys Arg Lys His
             160                 165                 170

 aag aaa gag aag aag aag aaa gac aaa gag cac agg cgg cca gct gag      817
 Lys Lys Glu Lys Lys Lys Lys Asp Lys Glu His Arg Arg Pro Ala Glu
         175                 180                 185

 gcc acc tcc tct ccc aca tct cct gag agg ccc agg cac cac cac cat      865
 Ala Thr Ser Ser Pro Thr Ser Pro Glu Arg Pro Arg His His His His
     190                 195                 200

 gac tcc gac tcc aac tcc ccc tgc tgt aag agg agg aag cgg gga cac      913
 Asp Ser Asp Ser Asn Ser Pro Cys Cys Lys Arg Arg Lys Arg Gly His
 205                 210                 215                 220

 agt ggg gac agg agg agc ccg tct cgc agg tgg cat gac aga ggc tct      961
 Ser Gly Asp Arg Arg Ser Pro Ser Arg Arg Trp His Asp Arg Gly Ser
                 225                 230                 235

 gag gcc tga tggctgg accctgctca ctgctgttgt gggaccctga accctccctt     1017
 Glu Ala 






      <210> 227
      <211> 1079
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (91)..(1032)

      <400> 227
 tttcgtctga gccgcccgcc gcctggaggg ggagacagct tcaggacacg caggccgcag     60

 cgagggcccg ggccctgggg atcccaggcc     atg gat gct ccc cac tcc aaa     111
                                      Met Asp Ala Pro His Ser Lys
                                        1               5

 gca gcc ctg gac agc att aac gag ctg ccc gag aac atc ctg ctg gag      159
 Ala Ala Leu Asp Ser Ile Asn Glu Leu Pro Glu Asn Ile Leu Leu Glu
          10                  15                  20

 ctg ttc acg cac gtg ccc gcc cgc cag ctg ctg ctg aac tgc cgc ctg      207
 Leu Phe Thr His Val Pro Ala Arg Gln Leu Leu Leu Asn Cys Arg Leu
      25                  30                  35

 gtc tgc agc ctc tgg cgg gac ctc atc gac ctc atg acc ctc tgg aaa      255
 Val Cys Ser Leu Trp Arg Asp Leu Ile Asp Leu Met Thr Leu Trp Lys
  40                  45                  50                  55

 cgc aag tgc ctg cga gag ggc ttc atc acc aag gac tgg gac cag ccc      303
 Arg Lys Cys Leu Arg Glu Gly Phe Ile Thr Lys Asp Trp Asp Gln Pro
                  60                  65                  70

 gtg gcc gac tgg aaa atc ttc tac ttc cta cgg agc ctg cat agg aac      351
 Val Ala Asp Trp Lys Ile Phe Tyr Phe Leu Arg Ser Leu His Arg Asn
              75                  80                  85

 ctc ctg cgc aac ccg tgt gct gaa gag gat atg ttt gca tgg caa att      399
 Leu Leu Arg Asn Pro Cys Ala Glu Glu Asp Met Phe Ala Trp Gln Ile
          90                  95                 100

 gat ttc aat ggt ggg gac cgc tgg aag gtg gag agc ctc cct gga gcc      447
 Asp Phe Asn Gly Gly Asp Arg Trp Lys Val Glu Ser Leu Pro Gly Ala
     105                 110                 115

 cac ggg aca gat ttt cct gac ccc aaa gtc aag aag tat ttt gtc aca      495
 His Gly Thr Asp Phe Pro Asp Pro Lys Val Lys Lys Tyr Phe Val Thr
 120                 125                 130                 135

 tcc tac gaa atg tgc ctc aag tcc cag ctg gtg gac ctt gta gcc gag      543
 Ser Tyr Glu Met Cys Leu Lys Ser Gln Leu Val Asp Leu Val Ala Glu
                 140                 145                 150

 ggc tac tgg gag gag cta cta gac aca ttc cgg ccg gac atc gtg gtt      591
 Gly Tyr Trp Glu Glu Leu Leu Asp Thr Phe Arg Pro Asp Ile Val Val
             155                 160                 165

 aag gac tgg ttt gct gcc aga gcc gac tgt ggc tgc acc tac caa ctc      639
 Lys Asp Trp Phe Ala Ala Arg Ala Asp Cys Gly Cys Thr Tyr Gln Leu
         170                 175                 180

 aaa gtg cag ctg gcc tcg gct gac tac ttc gtg ttg gcc tcc ttc gag      687
 Lys Val Gln Leu Ala Ser Ala Asp Tyr Phe Val Leu Ala Ser Phe Glu
     185                 190                 195

 ccc cca cct gtg acc atc caa cag tgg aac aat gcc aca tgg aca gag      735
 Pro Pro Pro Val Thr Ile Gln Gln Trp Asn Asn Ala Thr Trp Thr Glu
 200                 205                 210                 215

 gtc tcc tac acc ttc tca gac tac ccc cgg ggt gtc cgc tac atc ctc      783
 Val Ser Tyr Thr Phe Ser Asp Tyr Pro Arg Gly Val Arg Tyr Ile Leu
                 220                 225                 230

 ttc cag cat ggg ggc agg gac acc cag tac tgg gca ggc tgg tat ggg      831
 Phe Gln His Gly Gly Arg Asp Thr Gln Tyr Trp Ala Gly Trp Tyr Gly
             235                 240                 245

 ccc gag tac aca gca gat ggg gta gcc aga tgg acc ggg cca ggg tac      879
 Pro Glu Tyr Thr Ala Asp Gly Val Ala Arg Trp Thr Gly Pro Gly Tyr
         250                 255                 260

 gcg agg gtc agc tgc gaa aag act gca gga gag ggg gcc aac gct acg      927
 Ala Arg Val Ser Cys Glu Lys Thr Ala Gly Glu Gly Ala Asn Ala Thr
     265                 270                 275

 aag cgt ggc aaa tct gga ggc cac cgg gat gag caa cag agg ctc acg      975
 Lys Arg Gly Lys Ser Gly Gly His Arg Asp Glu Gln Gln Arg Leu Thr
 280                 285                 290                 295

 agc gaa aca cga ggg gga aag ccc gga aaa gcg tgg cgg aga caa caa     1023
 Ser Glu Thr Arg Gly Gly Lys Pro Gly Lys Ala Trp Arg Arg Gln Gln
                 300                 305                 310

 ggg gga tga gcaacca cacgcggaca aaacgcagac ccagacaacg agagaaggag     1079
 Gly Gly 






      <210> 228
      <211> 1826
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (415)..(1764)

      <400> 228
 agggcgcgct gcccggagct gcctgggttg cgctgccggc cacgtccccg cgccgggcct     60

 caggctcctt cctactgtcc gagggccacc aggccgccgg gggcctgctg cgcccggatg    120

 cgtctgttac tagagtggag agtctacctt cgtctcacat gtgccacaaa ggatggcatg    180

 gcccgggagt gccccaccac gtggctttca ccccctgcaa agccagactt cgcccagcga    240

 cacagtgtca agcccacagc tctccaagga ggaagatggt ccaggctggg agcatcccct    300

 tagcagcagc ctctgatccc ttggccaagc aggagggaac cattagcagc ctgaggagct    360

 ggctggctgg gagcctcggg gaccgcccag ccttgctccc agctcaccca caag  atg     417
                                                              Met
                                                                1

 tgg aca gct ctt gtg ctc att tgg att ttc tcc ttg tcc tta tct gaa      465
 Trp Thr Ala Leu Val Leu Ile Trp Ile Phe Ser Leu Ser Leu Ser Glu
               5                  10                  15

 agc cat gcg gca tcc aac gat cca cgc aac ttt gtc cct aac aaa atg      513
 Ser His Ala Ala Ser Asn Asp Pro Arg Asn Phe Val Pro Asn Lys Met
          20                  25                  30

 tgg aag gga tta gtc aag agg aat gca tct gtg gaa aca gtt gat aat      561
 Trp Lys Gly Leu Val Lys Arg Asn Ala Ser Val Glu Thr Val Asp Asn
      35                  40                  45

 aaa acg tct gag gat gta acc atg gca gca gct tct cct gtc aca ttg      609
 Lys Thr Ser Glu Asp Val Thr Met Ala Ala Ala Ser Pro Val Thr Leu
  50                  55                  60                  65

 acc aaa ggg act tcg gca gcc cac ctc aac tct atg gaa gtc aca aca      657
 Thr Lys Gly Thr Ser Ala Ala His Leu Asn Ser Met Glu Val Thr Thr
                  70                  75                  80

 gag gac aca agc agg aca gat gtg agt gaa cca gca act tca gga gtt      705
 Glu Asp Thr Ser Arg Thr Asp Val Ser Glu Pro Ala Thr Ser Gly Val
              85                  90                  95

 gca gct gat ggt gtg acc tcc att gct ccc acg gct gtg gcc tcc agt      753
 Ala Ala Asp Gly Val Thr Ser Ile Ala Pro Thr Ala Val Ala Ser Ser
         100                 105                 110

 acg act gcg gcc tcc att acg act gcg gcc tcc agt atg act gtg gcc      801
 Thr Thr Ala Ala Ser Ile Thr Thr Ala Ala Ser Ser Met Thr Val Ala
     115                 120                 125

 tcc agt gct ccc acg act gca gcc tcc agt aca act gtg gcc tcc att      849
 Ser Ser Ala Pro Thr Thr Ala Ala Ser Ser Thr Thr Val Ala Ser Ile
 130                 135                 140                 145

 gct ccc acg act gca gcc tcc agt atg act gcg gcc tcc agc act ccc      897
 Ala Pro Thr Thr Ala Ala Ser Ser Met Thr Ala Ala Ser Ser Thr Pro
                 150                 155                 160

 atg aca ctt gca ctc ccc gcg ccc acg tcc act tcc aca ggg cgg acc      945
 Met Thr Leu Ala Leu Pro Ala Pro Thr Ser Thr Ser Thr Gly Arg Thr
             165                 170                 175

 ccg tcc act acc gcc act ggg cat cca tct ctc agc aca gcc ctc gca      993
 Pro Ser Thr Thr Ala Thr Gly His Pro Ser Leu Ser Thr Ala Leu Ala
         180                 185                 190

 caa gtg cca aag agc agc gcg ttg cca aga aca gca acc ctg gcc aca     1041
 Gln Val Pro Lys Ser Ser Ala Leu Pro Arg Thr Ala Thr Leu Ala Thr
     195                 200                 205

 ttg gcc aca cgt gct cag act gta gcg acc aca gca aac aca agc agc     1089
 Leu Ala Thr Arg Ala Gln Thr Val Ala Thr Thr Ala Asn Thr Ser Ser
 210                 215                 220                 225

 ccc atg agc act cgt cca agt cct tcc aag cac atg ccc agt gac acc     1137
 Pro Met Ser Thr Arg Pro Ser Pro Ser Lys His Met Pro Ser Asp Thr
                 230                 235                 240

 gcg gca agc cct gta ccc cct atg cgt ccc caa gca caa ggt ccc att     1185
 Ala Ala Ser Pro Val Pro Pro Met Arg Pro Gln Ala Gln Gly Pro Ile
             245                 250                 255

 agc cag gtg tca gtg gac cag cct gtg gtt aac aca aca aat aaa tcc     1233
 Ser Gln Val Ser Val Asp Gln Pro Val Val Asn Thr Thr Asn Lys Ser
         260                 265                 270

 aca ccc atg ccc tca aac aca acc cca gag ccc gcc ccc acc ccc aca     1281
 Thr Pro Met Pro Ser Asn Thr Thr Pro Glu Pro Ala Pro Thr Pro Thr
     275                 280                 285

 gtg gtg acc acc acc aag gca caa gcc agg gag cca act gcc agc cca     1329
 Val Val Thr Thr Thr Lys Ala Gln Ala Arg Glu Pro Thr Ala Ser Pro
 290                 295                 300                 305

 gtg cca gta cct cac acc agg cca atc cct gag atg gag gcc atg tcc     1377
 Val Pro Val Pro His Thr Arg Pro Ile Pro Glu Met Glu Ala Met Ser
                 310                 315                 320

 ccc acg aca cag aca agc ccc atg cca tat acc cag agg gac gct ggg     1425
 Pro Thr Thr Gln Thr Ser Pro Met Pro Tyr Thr Gln Arg Asp Ala Gly
             325                 330                 335

 cca ggc aca tcc cag gca ccg gag cag gta gag act gaa gcc aca cca     1473
 Pro Gly Thr Ser Gln Ala Pro Glu Gln Val Glu Thr Glu Ala Thr Pro
         340                 345                 350

 ggt act gat tcc act ggg cca aca ccc agg agc tca ggg ggc act aag     1521
 Gly Thr Asp Ser Thr Gly Pro Thr Pro Arg Ser Ser Gly Gly Thr Lys
     355                 360                 365

 atg cca gcc acg gac tcg tgc cag ccc agc acc caa ggc cag tac atg     1569
 Met Pro Ala Thr Asp Ser Cys Gln Pro Ser Thr Gln Gly Gln Tyr Met
 370                 375                 380                 385

 gtg gtc acc act gag ccc ctc acc cag gcc gtg gta gac aaa act ctc     1617
 Val Val Thr Thr Glu Pro Leu Thr Gln Ala Val Val Asp Lys Thr Leu
                 390                 395                 400

 ctt ctg gtg gtg ctg tta ctc ggg gtg acc ctt ttc atc aca gtc ttg     1665
 Leu Leu Val Val Leu Leu Leu Gly Val Thr Leu Phe Ile Thr Val Leu
             405                 410                 415

 gtt ttg ttt gcc ctg cag gcc tat gag agc tac aag aag aag gac tac     1713
 Val Leu Phe Ala Leu Gln Ala Tyr Glu Ser Tyr Lys Lys Lys Asp Tyr
         420                 425                 430

 acc cag gtg gac tac tta atc aac ggg atg tat gcg gac tca gaa atg     1761
 Thr Gln Val Asp Tyr Leu Ile Asn Gly Met Tyr Ala Asp Ser Glu Met
     435                 440                 445

 tga gggg ggcgggggcc tggcgggagg cctggcccct tcctcgtcct ttccttttgc     1818
 


 ctttgaga                                                            1826




      <210> 229
      <211> 1501
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (410)..(1240)

      <400> 229
 ttattctact tcagtgtttg tgtggagggg gacaatctgg ttaaagttag tcttgcaagt     60

 ggtgacttta gcatttcccc caacttcatc aagcctttgc tcaggagcat gaaacccatc    120

 ttggaacata tatccaacat ctctgagagc cttgtcatca ttcatgaaaa gacgctcaac    180

 atcataagtc tttagagaaa cgcatattcg aatcatttca tatccactag aatcagccgc    240

 ggttccttcc tgcgccttta tctgcatccg ggtccgtggg attcgcgctc cactggtcag    300

 ctggggtcgc tctcgggtgg ttgggtgttg cttgttcccg ctgttccagc gtcgaagaac    360

 cattgggtct gccggtttga acttgttctg gaagctgtgc gtcaccgta    atg agg     415
                                                          Met Arg
                                                            1

 ctt gta att ctt gat aac tat gac ttg gct agt gaa tgg gca gcc aaa      463
 Leu Val Ile Leu Asp Asn Tyr Asp Leu Ala Ser Glu Trp Ala Ala Lys
           5                  10                  15

 tac atc tgt aat cgc atc att cag ttc aaa cct gga cag gac aga tat      511
 Tyr Ile Cys Asn Arg Ile Ile Gln Phe Lys Pro Gly Gln Asp Arg Tyr
      20                  25                  30

 ttt aca ctg ggt tta cca aca ggg agt aca cct tta gga tgc tat aaa      559
 Phe Thr Leu Gly Leu Pro Thr Gly Ser Thr Pro Leu Gly Cys Tyr Lys
  35                  40                  45                  50

 aaa cta ata gaa tat cat aag aat gga cac ctt tct ttt aaa tat gtg      607
 Lys Leu Ile Glu Tyr His Lys Asn Gly His Leu Ser Phe Lys Tyr Val
                  55                  60                  65

 aag acc ttt aat atg gat gaa tat gta gga ctt cca aga aat cat cct      655
 Lys Thr Phe Asn Met Asp Glu Tyr Val Gly Leu Pro Arg Asn His Pro
              70                  75                  80

 gaa agc tac cat tct tat atg tgg aat aat ttt ttt aag cat atc gat      703
 Glu Ser Tyr His Ser Tyr Met Trp Asn Asn Phe Phe Lys His Ile Asp
          85                  90                  95

 ata gat cct aat aat gca cat atc ctt gac ggg aat gct gca gat tta      751
 Ile Asp Pro Asn Asn Ala His Ile Leu Asp Gly Asn Ala Ala Asp Leu
     100                 105                 110

 caa gca gaa tgt gat gct ttt gaa aac aaa ata aaa gaa gct gga gga      799
 Gln Ala Glu Cys Asp Ala Phe Glu Asn Lys Ile Lys Glu Ala Gly Gly
 115                 120                 125                 130

 ata gat ctt ttt gtt gga gga att ggt cca gat ggt cat atc gct ttc      847
 Ile Asp Leu Phe Val Gly Gly Ile Gly Pro Asp Gly His Ile Ala Phe
                 135                 140                 145

 aat gag cct gga tcc agt tta gtg tca agg aca aga tta aag act cta      895
 Asn Glu Pro Gly Ser Ser Leu Val Ser Arg Thr Arg Leu Lys Thr Leu
             150                 155                 160

 gca atg gat acc atc ttg gca aat gcc aaa tat ttt gat gga gat tta      943
 Ala Met Asp Thr Ile Leu Ala Asn Ala Lys Tyr Phe Asp Gly Asp Leu
         165                 170                 175

 tca aaa gtg cca act atg gct cta act gtt ggt gtg ggg aca gtg atg      991
 Ser Lys Val Pro Thr Met Ala Leu Thr Val Gly Val Gly Thr Val Met
     180                 185                 190

 gat gct aga gaa gta atg atc ctt ata aca ggg gca cac aag gca ttt     1039
 Asp Ala Arg Glu Val Met Ile Leu Ile Thr Gly Ala His Lys Ala Phe
 195                 200                 205                 210

 gcc ctg tac aaa gca ata gaa gaa gga gtc aat cac atg tgg act gtt     1087
 Ala Leu Tyr Lys Ala Ile Glu Glu Gly Val Asn His Met Trp Thr Val
                 215                 220                 225

 tcc gct ttc cag cag cat ccc cgg act att ttt gta tgc gat gaa gat     1135
 Ser Ala Phe Gln Gln His Pro Arg Thr Ile Phe Val Cys Asp Glu Asp
             230                 235                 240

 gct act tta gaa tta aga gtt aaa act gtg aaa tac ttt aaa ggt cta     1183
 Ala Thr Leu Glu Leu Arg Val Lys Thr Val Lys Tyr Phe Lys Gly Leu
         245                 250                 255

 atg cat gtg cac aat aaa ctt gtg gat cca cta ttc agt atg aaa gat     1231
 Met His Val His Asn Lys Leu Val Asp Pro Leu Phe Ser Met Lys Asp
     260                 265                 270

 gga aac tga aggagac tggagcaaaa ttcagcttga atgaacagag cactttttac     1287
 Gly Asn 
 275

 taagtagtag atgaattttc agctatgcaa tatgacaaaa catggggaat tttgaagatt   1347

 gtcatttttt cattcgagtc tctatgttaa acattccata ttttgaatat ttatatcttg   1407

 tacttgggtt taagagaagt agctggctct caagattgac tggctattta ttataaagta   1467

 ctgaagtcac atagccacct ataaaaaaaa aaaa                               1501




      <210> 230
      <211> 2277
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (105)..(1457)

      <400> 230
 aggtttgggg aggagttgga gcctttgctg agctgacgtg gactgctggc agcaggtgca     60

 cacattttga ggagctgtgc cagggaaacg gagacccggg ggag atg gac gaa gac     116
                                                  Met Asp Glu Asp
                                                    1

 att ggt gtt ggg act gga ttt gat ccc agg ccc cag gct gca gcg tct      164
 Ile Gly Val Gly Thr Gly Phe Asp Pro Arg Pro Gln Ala Ala Ala Ser
   5                  10                  15                  20

 gtg ctt tac cag ccc tgt ggg gtc ctc acc gtc ccg tac cag gag act      212
 Val Leu Tyr Gln Pro Cys Gly Val Leu Thr Val Pro Tyr Gln Glu Thr
                  25                  30                  35

 cag agt acc agg ggc ttc agg ttg tgg gtg tgg gtt atg cat ccg ggc      260
 Gln Ser Thr Arg Gly Phe Arg Leu Trp Val Trp Val Met His Pro Gly
              40                  45                  50

 tgt gct aat ggg aac tgc cag ctg aag aag aca ctg agt cca gtt ttg      308
 Cys Ala Asn Gly Asn Cys Gln Leu Lys Lys Thr Leu Ser Pro Val Leu
          55                  60                  65

 gtc atg atg gtg aat aat gaa atc att atc act gag ttc gat ttt att      356
 Val Met Met Val Asn Asn Glu Ile Ile Ile Thr Glu Phe Asp Phe Ile
      70                  75                  80

 tcc agt tct tgt tta ttg tta gtg aaa ttc cgg gat gtg gag gtt cat      404
 Ser Ser Ser Cys Leu Leu Leu Val Lys Phe Arg Asp Val Glu Val His
  85                  90                  95                 100

 tct ggg gtt cgt tct tcc cac ctg gtg agg aag ctg gcc ggc agc aac      452
 Ser Gly Val Arg Ser Ser His Leu Val Arg Lys Leu Ala Gly Ser Asn
                 105                 110                 115

 tcc aaa cca tac gaa cgt tgc ctg cga tgc cag agt gac gca gat ccg      500
 Ser Lys Pro Tyr Glu Arg Cys Leu Arg Cys Gln Ser Asp Ala Asp Pro
             120                 125                 130

 ggg cgg gtc cgc ggc cgc ggc ggg aac atg gag gag ctg ctg agg cgc      548
 Gly Arg Val Arg Gly Arg Gly Gly Asn Met Glu Glu Leu Leu Arg Arg
         135                 140                 145

 gag ctg ggc tgc agc tct gtc agg gcc acg ggc cac tcg ggg ggc ggg      596
 Glu Leu Gly Cys Ser Ser Val Arg Ala Thr Gly His Ser Gly Gly Gly
     150                 155                 160

 tgc atc agc cag ggc cgg agc tac gac acg gat caa gga cga gtg ttc      644
 Cys Ile Ser Gln Gly Arg Ser Tyr Asp Thr Asp Gln Gly Arg Val Phe
 165                 170                 175                 180

 gtg aaa gtg aac ccc aag gcg gag gcc aga aga atg ttt gaa ggt gag      692
 Val Lys Val Asn Pro Lys Ala Glu Ala Arg Arg Met Phe Glu Gly Glu
                 185                 190                 195

 atg gca agt tta act gcc atc ctg aaa aca aac acg gtg aaa gtg ccc      740
 Met Ala Ser Leu Thr Ala Ile Leu Lys Thr Asn Thr Val Lys Val Pro
             200                 205                 210

 aag ccc atc aag gtt ctg gat gcc cca ggc ggc ggg agc gtg ctg gtg      788
 Lys Pro Ile Lys Val Leu Asp Ala Pro Gly Gly Gly Ser Val Leu Val
         215                 220                 225

 atg gag cac atg gac atg agg cat ctg agc agt cat gct gca aag ctt      836
 Met Glu His Met Asp Met Arg His Leu Ser Ser His Ala Ala Lys Leu
     230                 235                 240

 gga gcc cag ctg gcc gat tta cac ctt gat aac aag aag ctt gga gag      884
 Gly Ala Gln Leu Ala Asp Leu His Leu Asp Asn Lys Lys Leu Gly Glu
 245                 250                 255                 260

 atg cgc ctg aag gag gcg ggc aca gtg ggg aga gga ggt ggg cag gag      932
 Met Arg Leu Lys Glu Ala Gly Thr Val Gly Arg Gly Gly Gly Gln Glu
                 265                 270                 275

 gaa cgg ccc ttt gtg gcc cgg ttt gga ttt gac gtg gtg acg tgc tgt      980
 Glu Arg Pro Phe Val Ala Arg Phe Gly Phe Asp Val Val Thr Cys Cys
             280                 285                 290

 gga tac ctc ccc cag gtg aat gac tgg cag gag gac tgg gtc gtg ttc     1028
 Gly Tyr Leu Pro Gln Val Asn Asp Trp Gln Glu Asp Trp Val Val Phe
         295                 300                 305

 tat gcc cgg cag cgc att cag ccc cag atg gac atg gtg gag aag gag     1076
 Tyr Ala Arg Gln Arg Ile Gln Pro Gln Met Asp Met Val Glu Lys Glu
     310                 315                 320

 tct ggg gac agg gag gcc ctc cag ctt tgg tct gct ctg cag tta aag     1124
 Ser Gly Asp Arg Glu Ala Leu Gln Leu Trp Ser Ala Leu Gln Leu Lys
 325                 330                 335                 340

 atc cct gac ctg ttc cgt gac ctg gag atc atc cca gcc tta ctc cac     1172
 Ile Pro Asp Leu Phe Arg Asp Leu Glu Ile Ile Pro Ala Leu Leu His
                 345                 350                 355

 ggg gac ctc tgg ggt gga aac gta gca gag gat tcc tct ggg ccg gtg     1220
 Gly Asp Leu Trp Gly Gly Asn Val Ala Glu Asp Ser Ser Gly Pro Val
             360                 365                 370

 att ttt gac cca gct tct ttc tac ggc cac tcg gaa tat gag ctg gca     1268
 Ile Phe Asp Pro Ala Ser Phe Tyr Gly His Ser Glu Tyr Glu Leu Ala
         375                 380                 385

 ata gct ggc atg ttt ggg ggc ttt agc agc tcc ttt tac tcc gcc tac     1316
 Ile Ala Gly Met Phe Gly Gly Phe Ser Ser Ser Phe Tyr Ser Ala Tyr
     390                 395                 400

 cac ggc aaa atc ccc aag gcc cca gga ttc gag aag cgc ctt cag ttg     1364
 His Gly Lys Ile Pro Lys Ala Pro Gly Phe Glu Lys Arg Leu Gln Leu
 405                 410                 415                 420

 tat cag ctc ttt cac tac ttg aac cac tgg aat cat ttt gga tcg ggg     1412
 Tyr Gln Leu Phe His Tyr Leu Asn His Trp Asn His Phe Gly Ser Gly
                 425                 430                 435

 tac aga gga tcc tcc ctg aac atc atg agg aat ctg gtc aag tga gcg     1460
 Tyr Arg Gly Ser Ser Leu Asn Ile Met Arg Asn Leu Val Lys 
             440                 445                 450

 ggccttactc tggaaggagg cctcagaggt ttctccacag tcctcttctg ggcaaattct   1520

 tgtttcttca catgccggac tagcttaaga ccaatgcagt agcttatttc caagccttgc   1580

 aaagtatata atatctaaga ggaaaggttt tgtcatccca gcgttgtcca ctttgtgggg   1640

 ctttgtaggt agacggagcc acactacagg cagggtatga gcagagggat gtatggagtg   1700

 tgggtgactc tgagcctcac tgctgctgca aggtggggaa actgtaagtg aacccctgtg   1760

 ggtgcggggg agggtatccg gtgcgcaggg aggtggccag cgcccccggg cactgctgct   1820

 cataggtacc tttccgctgc ctcctccctg ctctcctgtg caggaatgtc tctgagctgt   1880

 tcacgttgat gcttcttggt tggcaagact tgggtgtaga catgaaacca tcttactaaa   1940

 agcgtcttaa aatgaccaat tccagaatca agcgtattcc gttttcttcc tgcatgatcc   2000

 ctgggccctc ccgcaggctg agcaagtctg taaactgatt ctgggagaaa ccaagctgct   2060

 ggccgtagga tgtccttggg tacatccagg agtcttcatt gcttctgtta ttaccccgtc   2120

 tcctctgcca ttttctacag cttgctgagt tgtcattcct ttgcaacatt aaaatacatg   2180

 ctgaactcat atttttcctt ccttcactgt tgtagtaaag agacatattt catgaatggc   2240

 attgatgcta ataaatcctt tgcacaaaaa aaaaaaa                            2277




      <210> 231
      <211> 604
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(512)

      <400> 231
 ccactgttta ggccaaggcc ctggggcact agaggcaaag agacacctga cccctttttg     60

 cccat    atg gcg ggg aga gca gca gcg gcc caa gca gga gct gca gcg     107
          Met Ala Gly Arg Ala Ala Ala Ala Gln Ala Gly Ala Ala Ala
            1               5                  10

 agc cgg gta cct gga ctc agc ggt agc aac ctc gcc cct tgc aac aaa      155
 Ser Arg Val Pro Gly Leu Ser Gly Ser Asn Leu Ala Pro Cys Asn Lys
  15                  20                  25                  30

 ggc aga ctg agc gcc aga gag gac gtt tcc aac tca aaa atg cag gct      203
 Gly Arg Leu Ser Ala Arg Glu Asp Val Ser Asn Ser Lys Met Gln Ala
                  35                  40                  45

 caa cag tac cag cag cag cgt cga aaa ttt gca gct gcc ttc ttg gca      251
 Gln Gln Tyr Gln Gln Gln Arg Arg Lys Phe Ala Ala Ala Phe Leu Ala
              50                  55                  60

 ttc att ttc ata ctg gca gct gtg gat act gct gaa gca ggg aag aaa      299
 Phe Ile Phe Ile Leu Ala Ala Val Asp Thr Ala Glu Ala Gly Lys Lys
          65                  70                  75

 gag aaa cca gaa aaa aaa gtg aag aag tct gac tgt gga gaa tgg cag      347
 Glu Lys Pro Glu Lys Lys Val Lys Lys Ser Asp Cys Gly Glu Trp Gln
      80                  85                  90

 tgg agt gtg tgt gtg ccc acc agt gga gac tgt ggg ctg ggc aca cgg      395
 Trp Ser Val Cys Val Pro Thr Ser Gly Asp Cys Gly Leu Gly Thr Arg
  95                 100                 105                 110

 gag ggc act cgg act gga gct gag tgc aag caa acc atg aag acc cag      443
 Glu Gly Thr Arg Thr Gly Ala Glu Cys Lys Gln Thr Met Lys Thr Gln
                 115                 120                 125

 aga tgt aag atc ccc tgc aac tgg aag aag caa ttt ggc gcg gag tgc      491
 Arg Cys Lys Ile Pro Cys Asn Trp Lys Lys Gln Phe Gly Ala Glu Cys
             130                 135                 140

 aaa tac cag ttc cag gcc tga ag accagaactg gaagtctgaa gcgagccctg      544
 Lys Tyr Gln Phe Gln Ala 
         145

 cacaatgccg aatgccagaa gactgtcacc atctccaagc cctgtggcat tcggcattgt    604




      <210> 232
      <211> 1849
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (236)..(1750)

      <400> 232
 ccactctgct cagctccgct ccaggaaggc cacctcctcc tccccctcct cctcccgctg     60

 tcaccactca ccgctcataa cctcaagggg gtggggaccc cagggctgga cacaccccac    120

 cgtggcccca gagctcagcc ggtcgcacgg acggacagtt ggaagccgga ccccagagcc    180

 tgaggtgggc agtgtgccag ggtcccttgc ggcctcctca agccctgtcc aggct atg     238
                                                              Met
                                                                1

 ggc atc aag aca gca ttg ccg gcg gct gag ctg ggc ctc tac tct ctg      286
 Gly Ile Lys Thr Ala Leu Pro Ala Ala Glu Leu Gly Leu Tyr Ser Leu
               5                  10                  15

 gtg ctg agt ggg gcc ctg gcc tat gct ggc cgg ggc ctc ctt gag gct      334
 Val Leu Ser Gly Ala Leu Ala Tyr Ala Gly Arg Gly Leu Leu Glu Ala
          20                  25                  30

 tca caa gat ggg gcc cac agg aag gcc ttc cgg gag tct gtg cga cct      382
 Ser Gln Asp Gly Ala His Arg Lys Ala Phe Arg Glu Ser Val Arg Pro
      35                  40                  45

 ggc tgg gag tac att ggc cgg aag atg gat gtg gct gac ttc gag tgg      430
 Gly Trp Glu Tyr Ile Gly Arg Lys Met Asp Val Ala Asp Phe Glu Trp
  50                  55                  60                  65

 gtg atg tgg ttc acc tcc ttt cgc aac gtc atc atc ttt gcc ctc tcc      478
 Val Met Trp Phe Thr Ser Phe Arg Asn Val Ile Ile Phe Ala Leu Ser
                  70                  75                  80

 gga cat gtg ctg ttt gct aaa ctc tgc acg atg gtt gcc cca aag ctc      526
 Gly His Val Leu Phe Ala Lys Leu Cys Thr Met Val Ala Pro Lys Leu
              85                  90                  95

 cgc tcc tgg atg tat gct gtg tac ggg gcc ttg gct gtg atg ggc aca      574
 Arg Ser Trp Met Tyr Ala Val Tyr Gly Ala Leu Ala Val Met Gly Thr
         100                 105                 110

 atg ggc cct tgg tac ctg ctg ctg ctg ctt ggt cac tgt gtg ggc ctc      622
 Met Gly Pro Trp Tyr Leu Leu Leu Leu Leu Gly His Cys Val Gly Leu
     115                 120                 125

 tat gtg gcc tcg ctt ttg ggc cag ccc tgg ctc tgt ctt ggc ctt ggc      670
 Tyr Val Ala Ser Leu Leu Gly Gln Pro Trp Leu Cys Leu Gly Leu Gly
 130                 135                 140                 145

 ttg gcc agc ctg gcc tcc ttc aag atg gac ccc cta atc tct tgg cag      718
 Leu Ala Ser Leu Ala Ser Phe Lys Met Asp Pro Leu Ile Ser Trp Gln
                 150                 155                 160

 agc ggg ttt gta aca ggc act ttt gat ctt caa gag gtg ctg ttt cat      766
 Ser Gly Phe Val Thr Gly Thr Phe Asp Leu Gln Glu Val Leu Phe His
             165                 170                 175

 ggg ggc agc agc ttc aca gtg ctg cgt tgc acc agc ttt gca ctg gag      814
 Gly Gly Ser Ser Phe Thr Val Leu Arg Cys Thr Ser Phe Ala Leu Glu
         180                 185                 190

 agc tgt gcc cac cct gac cgc cac tac tcc tta gct gac ctg ctc aag      862
 Ser Cys Ala His Pro Asp Arg His Tyr Ser Leu Ala Asp Leu Leu Lys
     195                 200                 205

 tac aac ttc tac ctg ccc ttc ttc ttc ttc ggg ccc atc atg acc ttt      910
 Tyr Asn Phe Tyr Leu Pro Phe Phe Phe Phe Gly Pro Ile Met Thr Phe
 210                 215                 220                 225

 gat cgc ttc cat gct cag gtg agc cag gtg gag cca gtg aga cgc gag      958
 Asp Arg Phe His Ala Gln Val Ser Gln Val Glu Pro Val Arg Arg Glu
                 230                 235                 240

 ggt gag ctg tgg cac atc cga gcc cag gca ggc cta agc gtg gtg gcc     1006
 Gly Glu Leu Trp His Ile Arg Ala Gln Ala Gly Leu Ser Val Val Ala
             245                 250                 255

 atc atg gcc gtc gac atc ttc ttt cac ttc ttc tac atc ctc act atc     1054
 Ile Met Ala Val Asp Ile Phe Phe His Phe Phe Tyr Ile Leu Thr Ile
         260                 265                 270

 ccc agc gac ctc aag ttc gcc aac cgc ctc cca gac agt gcc ctc gct     1102
 Pro Ser Asp Leu Lys Phe Ala Asn Arg Leu Pro Asp Ser Ala Leu Ala
     275                 280                 285

 ggc cta gcc tat tca aac ctg gtg tat gac tgg gtg aag gcg gcc gtc     1150
 Gly Leu Ala Tyr Ser Asn Leu Val Tyr Asp Trp Val Lys Ala Ala Val
 290                 295                 300                 305

 ctc ttt ggt gtt gtc aac act gtg gca tgc ctc gac cac ctg gac cca     1198
 Leu Phe Gly Val Val Asn Thr Val Ala Cys Leu Asp His Leu Asp Pro
                 310                 315                 320

 ccc cag cct ccc aag tgc atc acc gca ctc tac gtc ttt gcg gaa acg     1246
 Pro Gln Pro Pro Lys Cys Ile Thr Ala Leu Tyr Val Phe Ala Glu Thr
             325                 330                 335

 cac ttt gac cgt ggc atc aac gac tgg ctt tgc aaa tat gtg tat aac     1294
 His Phe Asp Arg Gly Ile Asn Asp Trp Leu Cys Lys Tyr Val Tyr Asn
         340                 345                 350

 cac att ggt ggg gag cat tcc gct gtg atc cca gag ctg gca gcc aca     1342
 His Ile Gly Gly Glu His Ser Ala Val Ile Pro Glu Leu Ala Ala Thr
     355                 360                 365

 gtg gcc aca ttt gcc atc acc aca ctg tgg ctt ggg cct tgt gac att     1390
 Val Ala Thr Phe Ala Ile Thr Thr Leu Trp Leu Gly Pro Cys Asp Ile
 370                 375                 380                 385

 gtc tac ctg tgg tca ttc ctt aac tgc ttt ggc ctc aac ttt gag ctc     1438
 Val Tyr Leu Trp Ser Phe Leu Asn Cys Phe Gly Leu Asn Phe Glu Leu
                 390                 395                 400

 tgg atg caa aaa ctg gca gag tgg ggg ccc cta gca cga att gag gcc     1486
 Trp Met Gln Lys Leu Ala Glu Trp Gly Pro Leu Ala Arg Ile Glu Ala
             405                 410                 415

 tct ctg tca gtg cag atg tcc cgt agg gtc cgg gcc ctg ttt gga gcc     1534
 Ser Leu Ser Val Gln Met Ser Arg Arg Val Arg Ala Leu Phe Gly Ala
         420                 425                 430

 atg aac ttc tgg gcc atc atc atg tac aac ctt gtg agc ctg aac agc     1582
 Met Asn Phe Trp Ala Ile Ile Met Tyr Asn Leu Val Ser Leu Asn Ser
     435                 440                 445

 ctc aaa ttc aca gag ctg gtt gcc cgg cgc ctg cta ctc aca ggg ttc     1630
 Leu Lys Phe Thr Glu Leu Val Ala Arg Arg Leu Leu Leu Thr Gly Phe
 450                 455                 460                 465

 ccc cag acc acg ctg tcc atc ctg ttt gtc acc tac tgt ggc gtc cag     1678
 Pro Gln Thr Thr Leu Ser Ile Leu Phe Val Thr Tyr Cys Gly Val Gln
                 470                 475                 480

 ctg gta aag gag cgt gag cga acc ttg gca ctg gag gag gag cag aag     1726
 Leu Val Lys Glu Arg Glu Arg Thr Leu Ala Leu Glu Glu Glu Gln Lys
             485                 490                 495

 cag gac aaa gag aag ccg gag tag gagggagcgg gtagagggat gggctctgct    1780
 Gln Asp Lys Glu Lys Pro Glu 
         500

 cagctattct tgggccagat ggggcctgac cgatagaata aaagactttt ctacaacaaa   1840

 aaaaaaaaa                                                           1849




      <210> 233
      <211> 3669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (401)..(2806)

      <400> 233
 atgactgcct tcctggagat ctctctcaag cagccaccca tagccactac tgagagagac     60

 agccaagaaa gaaaagtccc agaagagaag ggcagagatt acaaggaggg cggcagcagg    120

 aaggacaccg gccagtatga aaaggacttc ctggagatgg ttgcttatgg agtttcttac    180

 aacatgaaag ctgtcataga agataggcta aataaaaccg ttgaattatt ttctaccgaa    240

 aagaaagata aaaatgattc agagagagaa acttccaaga aaatagaaaa ggaactaaag    300

 ccttatggat ctagtaccat caacatccta aaagtgaaga ataagagaga gaaacaaagg    360

 gagaaattga cagacgagaa gaggaagaac cggaacaggc  atg cag act ggc tcc     415
                                              Met Gln Thr Gly Ser
                                                1               5

 tgc ggc atc aca ggg acc aag cag aag ccc act gcc agg gac aag gac      463
 Cys Gly Ile Thr Gly Thr Lys Gln Lys Pro Thr Ala Arg Asp Lys Asp
                  10                  15                  20

 agc cct ccc cgt gca ctc aaa gac aag tcc agg gat gag gac ccg agg      511
 Ser Pro Pro Arg Ala Leu Lys Asp Lys Ser Arg Asp Glu Asp Pro Arg
              25                  30                  35

 ctc agg aag gcc aaa ctg aag gag aaa ttc aag gac agt gca gaa aaa      559
 Leu Arg Lys Ala Lys Leu Lys Glu Lys Phe Lys Asp Ser Ala Glu Lys
          40                  45                  50

 gaa aag gac gac tct gtg aag atg agc aaa ggg gat gat aaa gta tcg      607
 Glu Lys Asp Asp Ser Val Lys Met Ser Lys Gly Asp Asp Lys Val Ser
      55                  60                  65

 cca tcc aaa gac cca ggc aag aaa aat gcc agg ccc agg gaa aag ctc      655
 Pro Ser Lys Asp Pro Gly Lys Lys Asn Ala Arg Pro Arg Glu Lys Leu
  70                  75                  80                  85

 cgg ggg gat ggc gac atg atg ata atc agc ttc cag agg atg ttc tcc      703
 Arg Gly Asp Gly Asp Met Met Ile Ile Ser Phe Gln Arg Met Phe Ser
                  90                  95                 100

 cag aag gac ctg gag atc gag gag cgc cac aag ggg cac aag gag agg      751
 Gln Lys Asp Leu Glu Ile Glu Glu Arg His Lys Gly His Lys Glu Arg
             105                 110                 115

 atg aag cag atg gag aag ctg agg cac cag tcc aga gac ccc aac ctc      799
 Met Lys Gln Met Glu Lys Leu Arg His Gln Ser Arg Asp Pro Asn Leu
         120                 125                 130

 aag gag agg gcg aag cca gca gac gac ggg cgg aag aag ggt ctg gaa      847
 Lys Glu Arg Ala Lys Pro Ala Asp Asp Gly Arg Lys Lys Gly Leu Glu
     135                 140                 145

 att cct gcc aag aaa cct ccg ggg ctg gac cct ccc ttt aaa gac aaa      895
 Ile Pro Ala Lys Lys Pro Pro Gly Leu Asp Pro Pro Phe Lys Asp Lys
 150                 155                 160                 165

 aag ctc aag gag ttg act cct att cca cct gct gcc gaa aat aag cca      943
 Lys Leu Lys Glu Leu Thr Pro Ile Pro Pro Ala Ala Glu Asn Lys Pro
                 170                 175                 180

 cgc cca gga tca ggt gca gac tcc aaa gac tgg ctc gca ggg cct cac      991
 Arg Pro Gly Ser Gly Ala Asp Ser Lys Asp Trp Leu Ala Gly Pro His
             185                 190                 195

 atg aaa gag gtc cta cct gca tct cct agg cct gac cag agc cga ccg     1039
 Met Lys Glu Val Leu Pro Ala Ser Pro Arg Pro Asp Gln Ser Arg Pro
         200                 205                 210

 gtt ctc cgc ggc atc aag tgg gct ttt gga aaa cgc cag cca ggc tcc     1087
 Val Leu Arg Gly Ile Lys Trp Ala Phe Gly Lys Arg Gln Pro Gly Ser
     215                 220                 225

 tgc caa gcc tct ctc cat aaa ctt tta ccg cta gag ggc gtc ttc tca     1135
 Cys Gln Ala Ser Leu His Lys Leu Leu Pro Leu Glu Gly Val Phe Ser
 230                 235                 240                 245

 aat tta caa gca aaa cct tcc cct tcc ccc aga gat aag ctg ctg gtt     1183
 Asn Leu Gln Ala Lys Pro Ser Pro Ser Pro Arg Asp Lys Leu Leu Val
                 250                 255                 260

 cct tcc ctc gaa ggg gcc att ccc ccg cac ctg gac gcc acc gag gac     1231
 Pro Ser Leu Glu Gly Ala Ile Pro Pro His Leu Asp Ala Thr Glu Asp
             265                 270                 275

 cag cag gct aca gcc ccc atc atc ccc ccg gag ccc agc tac ctg gag     1279
 Gln Gln Ala Thr Ala Pro Ile Ile Pro Pro Glu Pro Ser Tyr Leu Glu
         280                 285                 290

 ccg ctg gaa gag gac gcc ttc gcc ggc tcc gag gac gac ctg gac ctg     1327
 Pro Leu Glu Glu Asp Ala Phe Ala Gly Ser Glu Asp Asp Leu Asp Leu
     295                 300                 305

 ggg tcc ttc tca ctg ccg gag ctt ccc ttg cag act aaa gat gtc cca     1375
 Gly Ser Phe Ser Leu Pro Glu Leu Pro Leu Gln Thr Lys Asp Val Pro
 310                 315                 320                 325

 gat gtt gaa aca gaa ccc aca gaa gaa agt ctt gct cct tca gaa aag     1423
 Asp Val Glu Thr Glu Pro Thr Glu Glu Ser Leu Ala Pro Ser Glu Lys
                 330                 335                 340

 atc cct cca ggg gcc cct gtg gtc gta agg gcc tcc acc cag ctc ccc     1471
 Ile Pro Pro Gly Ala Pro Val Val Val Arg Ala Ser Thr Gln Leu Pro
             345                 350                 355

 aca gag ctc gag cct gag ccc tca gag gag cca aag ctg gac gtg gct     1519
 Thr Glu Leu Glu Pro Glu Pro Ser Glu Glu Pro Lys Leu Asp Val Ala
         360                 365                 370

 cta gaa gct acg gag gca gaa gca gtg cca gaa gag agg gcc tct ggg     1567
 Leu Glu Ala Thr Glu Ala Glu Ala Val Pro Glu Glu Arg Ala Ser Gly
     375                 380                 385

 gat ctg gac tcc agc atg gag ccc aca ccc gtt cgc cct gaa cag tgc     1615
 Asp Leu Asp Ser Ser Met Glu Pro Thr Pro Val Arg Pro Glu Gln Cys
 390                 395                 400                 405

 caa ctg gga agc aga gac cag ggg gcc gag gct gaa cac ctc cta ccc     1663
 Gln Leu Gly Ser Arg Asp Gln Gly Ala Glu Ala Glu His Leu Leu Pro
                 410                 415                 420

 cct gcc gca tcc ctc tgt gcc ccc gac acc cct tgc ccc cca tgg aca     1711
 Pro Ala Ala Ser Leu Cys Ala Pro Asp Thr Pro Cys Pro Pro Trp Thr
             425                 430                 435

 ctg tgg cac aag ccc agg ctg cgg aca gtg ctg gcc ccc acg aca aca     1759
 Leu Trp His Lys Pro Arg Leu Arg Thr Val Leu Ala Pro Thr Thr Thr
         440                 445                 450

 ctg cgg gcc tcc cgt gct gcc gcc cca gcc gaa ggc cct ccc tgc ggc     1807
 Leu Arg Ala Ser Arg Ala Ala Ala Pro Ala Glu Gly Pro Pro Cys Gly
     455                 460                 465

 atc gac cca gaa gcc aca gaa tca gaa cca aaa ccc acg gcc gaa gcc     1855
 Ile Asp Pro Glu Ala Thr Glu Ser Glu Pro Lys Pro Thr Ala Glu Ala
 470                 475                 480                 485

 ccg aaa gcc ccc aga gaa ccg gca gat gct cgt gaa cga gag caa gta     1903
 Pro Lys Ala Pro Arg Glu Pro Ala Asp Ala Arg Glu Arg Glu Gln Val
                 490                 495                 500

 ggg cac acc tca ctc caa gga gtg tgc ctc agg ccc gcg gct cgg agg     1951
 Gly His Thr Ser Leu Gln Gly Val Cys Leu Arg Pro Ala Ala Arg Arg
             505                 510                 515

 agg act acg ccc agc cca gca tcc gcg caa acg cca ctt cca gca ctc     1999
 Arg Thr Thr Pro Ser Pro Ala Ser Ala Gln Thr Pro Leu Pro Ala Leu
         520                 525                 530

 cac cca gca gct gaa cac gtc cac gca gca gac gcg gga ggt gat cca     2047
 His Pro Ala Ala Glu His Val His Ala Ala Asp Ala Gly Gly Asp Pro
     535                 540                 545

 gca gac gct ggc cac cat cgt gga cgc cat caa gct gga cgc cat cta     2095
 Ala Asp Ala Gly His His Arg Gly Arg His Gln Ala Gly Arg His Leu
 550                 555                 560                 565

 ccc cta cca cag ccg aca ggg cca acc cct act tcg aat acc tgc aga     2143
 Pro Leu Pro Gln Pro Thr Gly Pro Thr Pro Thr Ser Asn Thr Cys Arg
                 570                 575                 580

 tca ggg aag aag atc gag gag aag cgc aag atc ctg tgc tgt atc acg     2191
 Ser Gly Lys Lys Ile Glu Glu Lys Arg Lys Ile Leu Cys Cys Ile Thr
             585                 590                 595

 ccg cag gcg ccc cag tgc tac gcc gag tac gtc acc tac acg ggc tcc     2239
 Pro Gln Ala Pro Gln Cys Tyr Ala Glu Tyr Val Thr Tyr Thr Gly Ser
         600                 605                 610

 tac ctc ctg gac ggc aag ccg ctc agc aag ctc cac atc ccc gtg atc     2287
 Tyr Leu Leu Asp Gly Lys Pro Leu Ser Lys Leu His Ile Pro Val Ile
     615                 620                 625

 gca ccc cct ccc tcc ctg gcg gag ccc ctg aag gag ctg ttc agg cag     2335
 Ala Pro Pro Pro Ser Leu Ala Glu Pro Leu Lys Glu Leu Phe Arg Gln
 630                 635                 640                 645

 cag gag gcc gtc cgg gga aag ctg cgt cta cag cac agc atc gag cgg     2383
 Gln Glu Ala Val Arg Gly Lys Leu Arg Leu Gln His Ser Ile Glu Arg
                 650                 655                 660

 gag aag ctg atc gta tcc tgt gag cag gag att ctg cgg gtt cac tgc     2431
 Glu Lys Leu Ile Val Ser Cys Glu Gln Glu Ile Leu Arg Val His Cys
             665                 670                 675

 cgg gcg gcc agg acc atc gcc aac cag gca gtg cca ttc agc gcc tgc     2479
 Arg Ala Ala Arg Thr Ile Ala Asn Gln Ala Val Pro Phe Ser Ala Cys
         680                 685                 690

 acg atg ctg ctg gac tcc gag gtc tac aac atg ccc ctg gag agc cag     2527
 Thr Met Leu Leu Asp Ser Glu Val Tyr Asn Met Pro Leu Glu Ser Gln
     695                 700                 705

 ggt gac gag aac aag tca gtg cgc gac cgt ttc aac gcc cgc cag ttc     2575
 Gly Asp Glu Asn Lys Ser Val Arg Asp Arg Phe Asn Ala Arg Gln Phe
 710                 715                 720                 725

 atc tcc tgg ctc cag gac gtg gat gac aag tat gac cgc atg aag act     2623
 Ile Ser Trp Leu Gln Asp Val Asp Asp Lys Tyr Asp Arg Met Lys Thr
                 730                 735                 740

 tgc ctc ctc atg cgg cag cag cac gag gcc gcg gcc ctg aac gcc gtg     2671
 Cys Leu Leu Met Arg Gln Gln His Glu Ala Ala Ala Leu Asn Ala Val
             745                 750                 755

 cag agg atg gag tgg cag ctg aag gtg cag gaa ctg gac ccc gcc ggg     2719
 Gln Arg Met Glu Trp Gln Leu Lys Val Gln Glu Leu Asp Pro Ala Gly
         760                 765                 770

 cac aag tcc ctg tgc gtg aac gag gtg ccc tcc ttc tac gtg ccc atg     2767
 His Lys Ser Leu Cys Val Asn Glu Val Pro Ser Phe Tyr Val Pro Met
     775                 780                 785

 gtc gac gtc aac gac gac ttt gta ttg ttg ccg gca tga caccgcggga      2816
 Val Asp Val Asn Asp Asp Phe Val Leu Leu Pro Ala 
 790                 795                 800

 cggccgcagg acgcaggcga gggccgcacg gctgcccagg actgctgctg agccccaggg   2876

 gcggaggagg gagcgccctg tccacccggg cggggagaga ccccgagaga gactgcactt   2936

 ggccacagcg cctccatccc ttccagactg gtccagacgt cggggaggtg aaacacgtct   2996

 cttctctacc agctgccgcg gcgggggcaa agcccccaga gcctcactgg ccccggcggg   3056

 atgaggagac catgccgggc gcgcacacac ggcagcttct gtttgaaaac ggcgaccttc   3116

 gggccctttt ctccagcaac tgcagaggca tttcaggagt tggagaacgg agtacatttt   3176

 taaaattttt tgttccattc tgatcaacta aagaaaatta aggtgtccac ctctcacaaa   3236

 cagtgacctg caggtcggag gggcaggagc cccatcccag ccgtggttct gttgccgccg   3296

 agctgcgacg gcctcagact gggcttcaga cctggtgcgg agccaggcgg agggacacag   3356

 agccaggact cccagccgta ttgaaatgga gtcaaatccg cgtggtttgt atcttctttc   3416

 ctttaatctt gggcattttg tttctctttc tgagaacgta acttgaaaca ctacagagcc   3476

 aataatcata taaaaagtgt atccgtaaac gctgtacagt tttatatacc ttcacaatgt   3536

 acttttgctg ccttctagat aatttatttt gcaacacatt actgcacagt tgtaaataac   3596

 ttatgtactg taacatcact ttcagttatg tgtaaagaaa taaataaatt aattaaaatg   3656

 caaaaaaaaa aaa                                                      3669




      <210> 234
      <211> 4196
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (331)..(2919)

      <400> 234
 acaaagcaga atgaggagag tgatgtgatg atcgtggttg ttaaggaggg tggctgctgt     60

 ggcccagccc agcctggctc tgccctgctg gctgccttgg ttgagagcca gggactgctg    120

 gccattcaca gatggcgcct gggcgaggcc cctggttcta gtcctggtcc tgaaggttca    180

 cgtctgtggc agctggcagt tgctgggagt tcagtgcagg ctgtgaacat ctgtgtcgtc    240

 tctgggccac ccttgcaggg caccagctgt agcctgtcat tgcctctgga gcccatgaga    300

 ggtctggggt cctgaggctg ctggcagact     atg ggt aca acg gcc agc aca     351
                                      Met Gly Thr Thr Ala Ser Thr
                                        1               5

 gcc cag cag acg gac tcg gca ggc acc cca ttt gag ggc cta cag ggc      399
 Ala Gln Gln Thr Asp Ser Ala Gly Thr Pro Phe Glu Gly Leu Gln Gly
          10                  15                  20

 agt ggc acg atg gac agt cgg cac tcc gtc agc atc cac tcc ttc cag      447
 Ser Gly Thr Met Asp Ser Arg His Ser Val Ser Ile His Ser Phe Gln
      25                  30                  35

 agc act agc ttg cat aac agc aag gcc aag tcc atc atc ccc aac aag      495
 Ser Thr Ser Leu His Asn Ser Lys Ala Lys Ser Ile Ile Pro Asn Lys
  40                  45                  50                  55

 gtg gcc cct gtt gtg atc acg tac aac tgc aag gag gag ttc cag atc      543
 Val Ala Pro Val Val Ile Thr Tyr Asn Cys Lys Glu Glu Phe Gln Ile
                  60                  65                  70

 cat gat gag ctg ctc aag gct cat tac acg ttg ggc cgg ctc tcg gac      591
 His Asp Glu Leu Leu Lys Ala His Tyr Thr Leu Gly Arg Leu Ser Asp
              75                  80                  85

 aac acc cct gag cac tac ctg gtg caa ggc cgc tac ttc ctg gtg cgg      639
 Asn Thr Pro Glu His Tyr Leu Val Gln Gly Arg Tyr Phe Leu Val Arg
          90                  95                 100

 gat gtc act gag aag atg gat gtg ctg ggc acc gtg gga agc tgt ggg      687
 Asp Val Thr Glu Lys Met Asp Val Leu Gly Thr Val Gly Ser Cys Gly
     105                 110                 115

 gcc ccc aac ttc cgg cag gtg cag ggt ggg ctc act gtg ttc ggc atg      735
 Ala Pro Asn Phe Arg Gln Val Gln Gly Gly Leu Thr Val Phe Gly Met
 120                 125                 130                 135

 gga cag ccc agc ctc tta ggg ttc agg cgg gtc ctc cag aaa ctc cag      783
 Gly Gln Pro Ser Leu Leu Gly Phe Arg Arg Val Leu Gln Lys Leu Gln
                 140                 145                 150

 aag gac gga cat agg gag tgt gtc atc ttc tgt gtg cgg gag gaa cct      831
 Lys Asp Gly His Arg Glu Cys Val Ile Phe Cys Val Arg Glu Glu Pro
             155                 160                 165

 gtg ctt ttc ctg cgt gca gat gag gac ttt gtg tcc tac aca cct cga      879
 Val Leu Phe Leu Arg Ala Asp Glu Asp Phe Val Ser Tyr Thr Pro Arg
         170                 175                 180

 gac aag cag aac ctt cat gag aac ctc cag ggc ctt gga ccc ggg gtc      927
 Asp Lys Gln Asn Leu His Glu Asn Leu Gln Gly Leu Gly Pro Gly Val
     185                 190                 195

 cgg gtg gag agc ctg gag ctg gcc atc cgg aaa gag atc cac gac ttt      975
 Arg Val Glu Ser Leu Glu Leu Ala Ile Arg Lys Glu Ile His Asp Phe
 200                 205                 210                 215

 gcc cag ctg agc gag aac aca tac cat gtg tac cat aac acc gag gac     1023
 Ala Gln Leu Ser Glu Asn Thr Tyr His Val Tyr His Asn Thr Glu Asp
                 220                 225                 230

 ctg tgg ggg gag ccc cat gct gtg gcc atc cat ggt gag gac gac ttg     1071
 Leu Trp Gly Glu Pro His Ala Val Ala Ile His Gly Glu Asp Asp Leu
             235                 240                 245

 cat gtg acg gag gag gtg tac aag cgg ccc ctc ttc ctg cag ccc acc     1119
 His Val Thr Glu Glu Val Tyr Lys Arg Pro Leu Phe Leu Gln Pro Thr
         250                 255                 260

 tac agg tac cac cgc ctg ccc ctg ccc gag caa ggg agt ccc ctg gag     1167
 Tyr Arg Tyr His Arg Leu Pro Leu Pro Glu Gln Gly Ser Pro Leu Glu
     265                 270                 275

 gcc cag ttg gac gcc ttt gtc agt gtt ctc cgg gag acc ccc agc ctg     1215
 Ala Gln Leu Asp Ala Phe Val Ser Val Leu Arg Glu Thr Pro Ser Leu
 280                 285                 290                 295

 ctg cag ctc cgt gat gcc cac ggg cct ccc cca gcc ctc gtc ttc agc     1263
 Leu Gln Leu Arg Asp Ala His Gly Pro Pro Pro Ala Leu Val Phe Ser
                 300                 305                 310

 tgc cag atg ggc gtg ggc agg acc aac ctg ggc atg gtc ctg ggc acc     1311
 Cys Gln Met Gly Val Gly Arg Thr Asn Leu Gly Met Val Leu Gly Thr
             315                 320                 325

 ctc atc ctg ctt cac cgc agt ggg acc acc tcc cag cca gag gct gcc     1359
 Leu Ile Leu Leu His Arg Ser Gly Thr Thr Ser Gln Pro Glu Ala Ala
         330                 335                 340

 ccc acg cag gcc aag ccc ctg cct atg gag cag ttc cag gtg atc cag     1407
 Pro Thr Gln Ala Lys Pro Leu Pro Met Glu Gln Phe Gln Val Ile Gln
     345                 350                 355

 agc ttt ctc cgc atg gtg ccc cag gga agg agg atg gtg gaa gag gtg     1455
 Ser Phe Leu Arg Met Val Pro Gln Gly Arg Arg Met Val Glu Glu Val
 360                 365                 370                 375

 gac aga gcc atc act gcc tgt gcc gag ttg cat gac ctg aaa gaa gtg     1503
 Asp Arg Ala Ile Thr Ala Cys Ala Glu Leu His Asp Leu Lys Glu Val
                 380                 385                 390

 gtc ttg gaa aac cag aag aag tta gaa ggt atc cga ccg gag agc cca     1551
 Val Leu Glu Asn Gln Lys Lys Leu Glu Gly Ile Arg Pro Glu Ser Pro
             395                 400                 405

 gcc cag gga agc ggc agc cga cac agc gtc tgg cag agg gcg ctg tgg     1599
 Ala Gln Gly Ser Gly Ser Arg His Ser Val Trp Gln Arg Ala Leu Trp
         410                 415                 420

 agc ctg gag cga tac ttc tac ctg atc ctg ttt aac tac tac ctt cat     1647
 Ser Leu Glu Arg Tyr Phe Tyr Leu Ile Leu Phe Asn Tyr Tyr Leu His
     425                 430                 435

 gag cag tac ccg ctg gcc ttt gcc ctc agt ttc agc cgc tgg ctg tgt     1695
 Glu Gln Tyr Pro Leu Ala Phe Ala Leu Ser Phe Ser Arg Trp Leu Cys
 440                 445                 450                 455

 gcc cac cct gag ctg tac cgc ctg ccc gtg acg ctg agc tca gca ggc     1743
 Ala His Pro Glu Leu Tyr Arg Leu Pro Val Thr Leu Ser Ser Ala Gly
                 460                 465                 470

 cct gtg gct ccg agg gac ctc atc gcc agg ggc tcc cta cgg gag gac     1791
 Pro Val Ala Pro Arg Asp Leu Ile Ala Arg Gly Ser Leu Arg Glu Asp
             475                 480                 485

 gat ctg gtc tcc ccg gac gcg ctc agc act gtc aga gag atg gat gtg     1839
 Asp Leu Val Ser Pro Asp Ala Leu Ser Thr Val Arg Glu Met Asp Val
         490                 495                 500

 gcc aac ttc cgg cgg gtg ccc cgc atg ccc atc tac ggc acg gcc cag     1887
 Ala Asn Phe Arg Arg Val Pro Arg Met Pro Ile Tyr Gly Thr Ala Gln
     505                 510                 515

 ccc agc gcc aag gcc ctg ggg agc atc ctg gcc tac ctg acg gac gcc     1935
 Pro Ser Ala Lys Ala Leu Gly Ser Ile Leu Ala Tyr Leu Thr Asp Ala
 520                 525                 530                 535

 aag agg agg ctg cgg aag gtt gtc tgg gtg agc ctt cgg gag gag gcc     1983
 Lys Arg Arg Leu Arg Lys Val Val Trp Val Ser Leu Arg Glu Glu Ala
                 540                 545                 550

 gtg ttg gag tgt gac ggg cac acc tac agc ctg cgg tgg cct ggg ccc     2031
 Val Leu Glu Cys Asp Gly His Thr Tyr Ser Leu Arg Trp Pro Gly Pro
             555                 560                 565

 cct gtg gct cct gac cag ctg gag acc ctg gag gcc cag ctg aag gcc     2079
 Pro Val Ala Pro Asp Gln Leu Glu Thr Leu Glu Ala Gln Leu Lys Ala
         570                 575                 580

 cat cta agc gag cct ccc cca ggc aag gag ggc ccc ctg acc tac agg     2127
 His Leu Ser Glu Pro Pro Pro Gly Lys Glu Gly Pro Leu Thr Tyr Arg
     585                 590                 595

 ttc cag acc tgc ctt acc atg cag gag gtc ttc agc cag cac cgc agg     2175
 Phe Gln Thr Cys Leu Thr Met Gln Glu Val Phe Ser Gln His Arg Arg
 600                 605                 610                 615

 gcc tgt cct ggc ctc acc tac cac cgc atc ccc atg ccg gac ttc tgt     2223
 Ala Cys Pro Gly Leu Thr Tyr His Arg Ile Pro Met Pro Asp Phe Cys
                 620                 625                 630

 gcc ccc cga gag gag gac ttt gac cag ctg ctg gag gcc ctg cgg gcc     2271
 Ala Pro Arg Glu Glu Asp Phe Asp Gln Leu Leu Glu Ala Leu Arg Ala
             635                 640                 645

 gcc ctc tcc aag gac cca ggc act ggc ttc gtg ttc agc tgc ctc agc     2319
 Ala Leu Ser Lys Asp Pro Gly Thr Gly Phe Val Phe Ser Cys Leu Ser
         650                 655                 660

 ggc cag ggc cgt acc aca act gcg atg gtg gtg gct gtc ctg gcc ttc     2367
 Gly Gln Gly Arg Thr Thr Thr Ala Met Val Val Ala Val Leu Ala Phe
     665                 670                 675

 tgg cac atc caa gta cgt gtg gcc tct caa ggc ttc ccc gag gtg ggt     2415
 Trp His Ile Gln Val Arg Val Ala Ser Gln Gly Phe Pro Glu Val Gly
 680                 685                 690                 695

 gag gag gag ctc gtg agt gtg cct gat gcc aag ttc act aag ggt gaa     2463
 Glu Glu Glu Leu Val Ser Val Pro Asp Ala Lys Phe Thr Lys Gly Glu
                 700                 705                 710

 ttt cag gta gta atg aag gtg gtg cag ctg cta ccc gat ggg cac cgt     2511
 Phe Gln Val Val Met Lys Val Val Gln Leu Leu Pro Asp Gly His Arg
             715                 720                 725

 gtg aag aag gag gtg gac gca gcg ctg gac act gtc agc gag acc atg     2559
 Val Lys Lys Glu Val Asp Ala Ala Leu Asp Thr Val Ser Glu Thr Met
         730                 735                 740

 acg ccc atg cac tac cac ctg cgg gag atc atc atc tgc acc tac cgc     2607
 Thr Pro Met His Tyr His Leu Arg Glu Ile Ile Ile Cys Thr Tyr Arg
     745                 750                 755

 cag gcg aag gca gcg aaa gag gcg cag gaa atg cgg agg ctg cag ctg     2655
 Gln Ala Lys Ala Ala Lys Glu Ala Gln Glu Met Arg Arg Leu Gln Leu
 760                 765                 770                 775

 cgg agc ctg cag tac ttg gag cgc tat gtc tgc ctg att ctc ttc aac     2703
 Arg Ser Leu Gln Tyr Leu Glu Arg Tyr Val Cys Leu Ile Leu Phe Asn
                 780                 785                 790

 gcg tac ctc cac ctg gag aag gcc gac tcc tgg cag agg ccc ttc agc     2751
 Ala Tyr Leu His Leu Glu Lys Ala Asp Ser Trp Gln Arg Pro Phe Ser
             795                 800                 805

 acc tgg atg cag gag gtg gca tcg aag gct ggc atc tac gag atc ctt     2799
 Thr Trp Met Gln Glu Val Ala Ser Lys Ala Gly Ile Tyr Glu Ile Leu
         810                 815                 820

 aac gag ctg ggc ttc ccc gag ctg gag agc ggg gag gac cag ccc ttc     2847
 Asn Glu Leu Gly Phe Pro Glu Leu Glu Ser Gly Glu Asp Gln Pro Phe
     825                 830                 835

 tcc agg ctg cgc tac cgg tgg cag gag cag agc tgc agc ctc gag ccc     2895
 Ser Arg Leu Arg Tyr Arg Trp Gln Glu Gln Ser Cys Ser Leu Glu Pro
 840                 845                 850                 855

 tct gcc ccc gag gac ttg ctg tag ggggccttac tccctgtccc cccacccaca    2949
 Ser Ala Pro Glu Asp Leu Leu 
                 860

 gggccccacg caggcctggg gtgtctgagg tgctcttggc tgggagcggc cctgaggggt   3009

 gctggccttg aaatgattcc cccacttcct ggagagactg agcggagttg ggagcctttt   3069

 tagaaagaac tttttatagg acagggagac agcacagcca tcccttgcaa accaccaagg   3129

 tgtgtggctg acctccaggg aggagcactc actggagtgc tcacaaggtg cacactgctg   3189

 tgtgtacctt gcagacaggc cggcgttcag cctccaaggg gctcactccc ccagttgcca   3249

 aacactgtgg atctctctgt cctcttctcc cctctctcag attggcctgg cagcccctgg   3309

 cacagagcag acccggccac tggtagctcc ccacttcctt actcctgctg ctctgccatt   3369

 gccgctcccc ttcttgctgc ccaagcactg ccctcgggcg tctggcagcc tgaggtgggt   3429

 ggaggggaca gtgttctgga tagatctatt atgtgaaagg cagcttcacc cagttttctg   3489

 gactctcatg cccccatctc cgacctggga gacttcagga atgacaacct acccagcctg   3549

 gtggggctgg caggatggtg gaggtttctc aaggagctgg agacttcagg gagcccctct   3609

 catggggagg aaagagcttc ccagggggcg aacgcagcac agaggaagag gcctgctcca   3669

 cttgtctggg aacctgggca ggaggcacag aggaagccaa ggcctggagc tgcaggtccc   3729

 ccggcatctc tctctgtccc ggcagcccag gatggcctgg tgcccccacc tgctgcagca   3789

 ggagccccaa ggagtgctag ctgagggtgg ttgctggggt ggtcctcatg gacagtgagg   3849

 tgtgcaaggg tgcactgagg gtggtgggag gggatcacct gggttccagg ccatccttgc   3909

 tgagcatctt tgagcctgcc ttccggtggg agcagaaaag gccagaccct gctgagttag   3969

 aggctgctgg gatccactgt ttccacacag cgggaaggct gctgggaaca ggtggcagag   4029

 aagtgccatg tttgcgttga gccttgcagc tcttccagct ggggactggt gcttgctgaa   4089

 acccaggagc tgaacagtga ggaggctgtc caccttgctt ggctcactgg gaccaggaaa   4149

 gcctgtcttt ggttaggctc gtgtacttct gcaggaaaaa aaaaaaa                 4196




      <210> 235
      <211> 1314
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (277)..(1314)

      <400> 235
 gcgtcgacga tttcgtctga gacggtttgg cggtgagtcc tgggccatgt tcatctgaaa     60

 ggcccgcaac ccgggaaacg tcaaaacaaa cagaaggact tgggattccg gagcagtcgc    120

 ccctatcgct gctcctgcag ttgcggacgc caccgacccc gccgccggag gactgggcac    180

 tgaaaggcct ctaggcctag gcgcggcccg cggagccaga cgtgttgctg ccgtgagtaa    240

 aacgagcgcc gtctccacaa gagtttacaa attaaa  atg gag gaa att tcg ttg     294
                                          Met Glu Glu Ile Ser Leu
                                            1               5

 tct ggc ctg gat act aac aag cta gag gcc atc gct cag gag att tac      342
 Ser Gly Leu Asp Thr Asn Lys Leu Glu Ala Ile Ala Gln Glu Ile Tyr
              10                  15                  20

 gcg gac ctg gtc gag gat tct tgt ttg gga ttc tgc ttt gag gta cac      390
 Ala Asp Leu Val Glu Asp Ser Cys Leu Gly Phe Cys Phe Glu Val His
          25                  30                  35

 cgg gct gtc aag tgt ggc tac ttc ttc ttg gac gac acg gac cct gat      438
 Arg Ala Val Lys Cys Gly Tyr Phe Phe Leu Asp Asp Thr Asp Pro Asp
      40                  45                  50

 agc atg aag gat ttt gag atc gtg gac cag ccg ggc ttg gac atc ttt      486
 Ser Met Lys Asp Phe Glu Ile Val Asp Gln Pro Gly Leu Asp Ile Phe
  55                  60                  65                  70

 gga cag gtt ttc aac cag tgg aag agc aag gag tgt gtt tgc ccc aat      534
 Gly Gln Val Phe Asn Gln Trp Lys Ser Lys Glu Cys Val Cys Pro Asn
                  75                  80                  85

 tgc agt cgc agc att gcc gcc tcc cgc ttt gct ccc cat ctg gag aag      582
 Cys Ser Arg Ser Ile Ala Ala Ser Arg Phe Ala Pro His Leu Glu Lys
              90                  95                 100

 tgc ctg gga atg ggt cgg aac agc agc cga atc gcc aac cgc cgg att      630
 Cys Leu Gly Met Gly Arg Asn Ser Ser Arg Ile Ala Asn Arg Arg Ile
         105                 110                 115

 gcc aat agc aac aat atg aat aag tct gag agt gac caa gaa gat aat      678
 Ala Asn Ser Asn Asn Met Asn Lys Ser Glu Ser Asp Gln Glu Asp Asn
     120                 125                 130

 gat gac atc aat gac aac gac tgg tcc tat ggc tcg gag aag aaa gcc      726
 Asp Asp Ile Asn Asp Asn Asp Trp Ser Tyr Gly Ser Glu Lys Lys Ala
 135                 140                 145                 150

 aag aag aga aag tca gac aag aac ccc aat tcc cct cga aga tcc aag      774
 Lys Lys Arg Lys Ser Asp Lys Asn Pro Asn Ser Pro Arg Arg Ser Lys
                 155                 160                 165

 tca tta aaa cac aaa aat ggg gaa ctt agc aat tcg gat cct ttt aag      822
 Ser Leu Lys His Lys Asn Gly Glu Leu Ser Asn Ser Asp Pro Phe Lys
             170                 175                 180

 tat aac aat tca act ggg atc agc tat gag acc ctg ggg ccg gag gag      870
 Tyr Asn Asn Ser Thr Gly Ile Ser Tyr Glu Thr Leu Gly Pro Glu Glu
         185                 190                 195

 ctt cgc agc ctg cta acc acg caa tgt ggg gtg att tct gaa cac acc      918
 Leu Arg Ser Leu Leu Thr Thr Gln Cys Gly Val Ile Ser Glu His Thr
     200                 205                 210

 aag aag atg tgc aca agg tcc ctg cgc tgc cca cag cac aca gat gag      966
 Lys Lys Met Cys Thr Arg Ser Leu Arg Cys Pro Gln His Thr Asp Glu
 215                 220                 225                 230

 cag agg cga acc gta tgg att tat ttt ctc ggg ccc tcg gct gtc ctt     1014
 Gln Arg Arg Thr Val Trp Ile Tyr Phe Leu Gly Pro Ser Ala Val Leu
                 235                 240                 245

 cca gag gtc gag agc tcc ctg gat aat gac agc ttt gac atg act gac     1062
 Pro Glu Val Glu Ser Ser Leu Asp Asn Asp Ser Phe Asp Met Thr Asp
             250                 255                 260

 agc cag gcc ctg atc agc cgg ctt cag tgg gac ggc tcc tct gac ctc     1110
 Ser Gln Ala Leu Ile Ser Arg Leu Gln Trp Asp Gly Ser Ser Asp Leu
         265                 270                 275

 tca ccc tct gat tca ggc tcc tcc aag acg agt gaa aat cag gga tgg     1158
 Ser Pro Ser Asp Ser Gly Ser Ser Lys Thr Ser Glu Asn Gln Gly Trp
     280                 285                 290

 ggt cta ggt acc aac agc tct gag tca cgg aaa acc aaa aaa aaa aaa     1206
 Gly Leu Gly Thr Asn Ser Ser Glu Ser Arg Lys Thr Lys Lys Lys Lys
 295                 300                 305                 310

 tcc cat ctg agc ctg gta ggg act gcc tcc ggc cta ggt tcc aac aag     1254
 Ser His Leu Ser Leu Val Gly Thr Ala Ser Gly Leu Gly Ser Asn Lys
                 315                 320                 325

 aag aag aag cca aag cca ccg gca ccc ccg acg ccc agc atc tat gat     1302
 Lys Lys Lys Pro Lys Pro Pro Ala Pro Pro Thr Pro Ser Ile Tyr Asp
             330                 335                 340

 gac atc aac tga                                                     1314
 Asp Ile Asn 
         345





      <210> 236
      <211> 3224
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2673)

      <400> 236
  atg gaa gga ggc ggc aag ccc aac tct tcg tct aac agc cgg gac gat      48
  Met Glu Gly Gly Gly Lys Pro Asn Ser Ser Ser Asn Ser Arg Asp Asp
    1               5                  10                  15

 ggc aac agc gtc ttc ccc gcc aag gcg tcc gcg ccg ggc gcg ggg ccg       96
 Gly Asn Ser Val Phe Pro Ala Lys Ala Ser Ala Pro Gly Ala Gly Pro
              20                  25                  30

 gcc gcg gcc gag aag cgc ctg ggc acc ccg ccg ggg ggc ggc ggg gcc      144
 Ala Ala Ala Glu Lys Arg Leu Gly Thr Pro Pro Gly Gly Gly Gly Ala
          35                  40                  45

 ggc gcg aag gag cac ggc aac tcc gtg tgc ttc aag gtg gac ggc ggt      192
 Gly Ala Lys Glu His Gly Asn Ser Val Cys Phe Lys Val Asp Gly Gly
      50                  55                  60

 ggc ggc ggt ggc ggc agc ggc ggc ggc ggc gag gag ccg gcg ggg ggc      240
 Gly Gly Gly Gly Gly Ser Gly Gly Gly Gly Glu Glu Pro Ala Gly Gly
  65                  70                  75                  80

 ttc gaa gac gcc gag ggg ccc cgg cgg cag tac ggc ttc atg cag agg      288
 Phe Glu Asp Ala Glu Gly Pro Arg Arg Gln Tyr Gly Phe Met Gln Arg
                  85                  90                  95

 cag ttc acc tcc atg ctg cag ccc ggg gtc aac aaa ttc tcc ctc cgc      336
 Gln Phe Thr Ser Met Leu Gln Pro Gly Val Asn Lys Phe Ser Leu Arg
             100                 105                 110

 atg ttt ggg agc cag aag gcg gtg gaa aag gag cag gaa agg gtt aaa      384
 Met Phe Gly Ser Gln Lys Ala Val Glu Lys Glu Gln Glu Arg Val Lys
         115                 120                 125

 act gca ggc ttc tgg att atc cac cct tac agt gat ttc agg ttt tac      432
 Thr Ala Gly Phe Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr
     130                 135                 140

 tgg gat tta ata atg ctt ata atg atg gtt gga aat cta gtc atc ata      480
 Trp Asp Leu Ile Met Leu Ile Met Met Val Gly Asn Leu Val Ile Ile
 145                 150                 155                 160

 cca gtt gga atc aca ttc ttt aca gag caa aca aca aca cca tgg att      528
 Pro Val Gly Ile Thr Phe Phe Thr Glu Gln Thr Thr Thr Pro Trp Ile
                 165                 170                 175

 att ttc aat gtg gca tca gat aca gtt ttc cta ttg gac ctg atc atg      576
 Ile Phe Asn Val Ala Ser Asp Thr Val Phe Leu Leu Asp Leu Ile Met
             180                 185                 190

 aat ttt agg act ggg act gtc aat gaa gac agt tct gaa atc atc ctg      624
 Asn Phe Arg Thr Gly Thr Val Asn Glu Asp Ser Ser Glu Ile Ile Leu
         195                 200                 205

 gac ccc aaa gtg atc aag atg aat tat tta aaa agc tgg ttt gtg gtt      672
 Asp Pro Lys Val Ile Lys Met Asn Tyr Leu Lys Ser Trp Phe Val Val
     210                 215                 220

 gac ttc atc tca tcc atc cca gtg gat tat atc ttt ctt att gta gaa      720
 Asp Phe Ile Ser Ser Ile Pro Val Asp Tyr Ile Phe Leu Ile Val Glu
 225                 230                 235                 240

 aaa gga atg gat tct gaa gtt tac aag aca gcc agg gcc ctt cgc att      768
 Lys Gly Met Asp Ser Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile
                 245                 250                 255

 gtg agg ttt aca aaa att ctc agt ctc ttg cgt tta tta cga ctt tca      816
 Val Arg Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser
             260                 265                 270

 agg tta att aga tac ata cat caa tgg gaa gag ata ttc cac atg aca      864
 Arg Leu Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr
         275                 280                 285

 tat gat ctc gcc agt gca gtg gtg aga att ttt aat ctc atc ggc atg      912
 Tyr Asp Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met
     290                 295                 300

 atg ctg ctc ctg tgc cac tgg gat ggt tgt ctt cag ttc tta gta cca      960
 Met Leu Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro
 305                 310                 315                 320

 cta ctg cag gac ttc cca cca gat tgc tgg gtg tct tta aat gaa atg     1008
 Leu Leu Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Leu Asn Glu Met
                 325                 330                 335

 gtt aat gat tct tgg gga aag cag tat tca tac gca ctc ttc aaa gct     1056
 Val Asn Asp Ser Trp Gly Lys Gln Tyr Ser Tyr Ala Leu Phe Lys Ala
             340                 345                 350

 atg agt cac atg ctg tgc att ggg tat gga gcc caa gcc cca gtc agc     1104
 Met Ser His Met Leu Cys Ile Gly Tyr Gly Ala Gln Ala Pro Val Ser
         355                 360                 365

 atg tct gac ctc tgg att acc atg ctg agc atg atc gtc ggg gcc acc     1152
 Met Ser Asp Leu Trp Ile Thr Met Leu Ser Met Ile Val Gly Ala Thr
     370                 375                 380

 tgc tat gcc atg ttt gtc ggc cat gcc acc gct tta atc cag tct ctg     1200
 Cys Tyr Ala Met Phe Val Gly His Ala Thr Ala Leu Ile Gln Ser Leu
 385                 390                 395                 400

 gat tct tcg agg cgg cag tat caa gag aag tat aag caa gtg gaa caa     1248
 Asp Ser Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln
                 405                 410                 415

 tac atg tca ttc cat aag tta cca gct gat atg cgt cag aag ata cat     1296
 Tyr Met Ser Phe His Lys Leu Pro Ala Asp Met Arg Gln Lys Ile His
             420                 425                 430

 gat tac tat gaa cac aga tac caa ggc aaa atc ttt gat gag gaa aat     1344
 Asp Tyr Tyr Glu His Arg Tyr Gln Gly Lys Ile Phe Asp Glu Glu Asn
         435                 440                 445

 att ctc aat gaa ctc aat gat cct ctg aga gag gag ata gtc aac ttc     1392
 Ile Leu Asn Glu Leu Asn Asp Pro Leu Arg Glu Glu Ile Val Asn Phe
     450                 455                 460

 aac tgt cgg aaa ctg gtg gct aca atg cct tta ttt gct aat gcg gat     1440
 Asn Cys Arg Lys Leu Val Ala Thr Met Pro Leu Phe Ala Asn Ala Asp
 465                 470                 475                 480

 cct aat ttt gtg act gcc atg ctg agc aag ttg aga ttt gag gtg ttt     1488
 Pro Asn Phe Val Thr Ala Met Leu Ser Lys Leu Arg Phe Glu Val Phe
                 485                 490                 495

 caa cct gga gat tat atc ata cga gaa gga gcc gtg ggt aaa aaa atg     1536
 Gln Pro Gly Asp Tyr Ile Ile Arg Glu Gly Ala Val Gly Lys Lys Met
             500                 505                 510

 tat ttc att caa cac ggt gtt gct ggt gtc att aca aaa tcc agt aaa     1584
 Tyr Phe Ile Gln His Gly Val Ala Gly Val Ile Thr Lys Ser Ser Lys
         515                 520                 525

 gaa atg aag ctg aca gat ggc tct tac ttt gga gag att tgc ctg ctg     1632
 Glu Met Lys Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu
     530                 535                 540

 acc aaa gga cgt cgt act gcc agt gtt cga gct gat aca tat tgt cgt     1680
 Thr Lys Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg
 545                 550                 555                 560

 ctt tac tca ctt tcc gtg gac aat ttc aac gag gtc ctg gag gaa tat     1728
 Leu Tyr Ser Leu Ser Val Asp Asn Phe Asn Glu Val Leu Glu Glu Tyr
                 565                 570                 575

 cca atg atg agg aga gcc ttt gag aca gtt gcc att gac cga cta gat     1776
 Pro Met Met Arg Arg Ala Phe Glu Thr Val Ala Ile Asp Arg Leu Asp
             580                 585                 590

 cga ata gga aag aaa aat tca att ctt ctg caa aag ttc cag aag gat     1824
 Arg Ile Gly Lys Lys Asn Ser Ile Leu Leu Gln Lys Phe Gln Lys Asp
         595                 600                 605

 ctg aac act ggt gtt ttc aac aat cag gag aac gaa atc ctc aag cag     1872
 Leu Asn Thr Gly Val Phe Asn Asn Gln Glu Asn Glu Ile Leu Lys Gln
     610                 615                 620

 att gtg aaa cat gac agg gag atg gtg cag gca atc gct ccc atc aat     1920
 Ile Val Lys His Asp Arg Glu Met Val Gln Ala Ile Ala Pro Ile Asn
 625                 630                 635                 640

 tat cct caa atg aca acc ctg aat tcc aca tcg tct act acg acc ccg     1968
 Tyr Pro Gln Met Thr Thr Leu Asn Ser Thr Ser Ser Thr Thr Thr Pro
                 645                 650                 655

 acc tcc cgc atg agg aca caa tct cca ccg gtg tac aca gcg acc agc     2016
 Thr Ser Arg Met Arg Thr Gln Ser Pro Pro Val Tyr Thr Ala Thr Ser
             660                 665                 670

 ctg tct cac agc aac ctg cac tcc ccc agt ccc agc aca cag acc ccc     2064
 Leu Ser His Ser Asn Leu His Ser Pro Ser Pro Ser Thr Gln Thr Pro
         675                 680                 685

 cag cca tca gcc atc ctg tca ccc tgc tcc tac acc acc gcg gtc tgc     2112
 Gln Pro Ser Ala Ile Leu Ser Pro Cys Ser Tyr Thr Thr Ala Val Cys
     690                 695                 700

 agc cct cct gta cag agc cct ctg gcc gct cga act ttc cac tat gcc     2160
 Ser Pro Pro Val Gln Ser Pro Leu Ala Ala Arg Thr Phe His Tyr Ala
 705                 710                 715                 720

 tcc ccc acc gcc tcc cag ctg tca ctc atg caa cag cag ccg cag cag     2208
 Ser Pro Thr Ala Ser Gln Leu Ser Leu Met Gln Gln Gln Pro Gln Gln
                 725                 730                 735

 cag gta cag cag tcc cag ccg ccg cag act cag cca cag cag ccg tcc     2256
 Gln Val Gln Gln Ser Gln Pro Pro Gln Thr Gln Pro Gln Gln Pro Ser
             740                 745                 750

 ccg cag cca cag aca cct ggc agc tcc acg ccg aaa aat gaa gtg cac     2304
 Pro Gln Pro Gln Thr Pro Gly Ser Ser Thr Pro Lys Asn Glu Val His
         755                 760                 765

 aag agc acg cag gcg ctt cac aac acc aac ctg acc cgg gaa gtc agg     2352
 Lys Ser Thr Gln Ala Leu His Asn Thr Asn Leu Thr Arg Glu Val Arg
     770                 775                 780

 cca ttt tcc gcc tgg cag ccc tcg ctg ccc cat gag gtg tcc act ttg     2400
 Pro Phe Ser Ala Trp Gln Pro Ser Leu Pro His Glu Val Ser Thr Leu
 785                 790                 795                 800

 att tcc aga cct cat ccc act gtg ggg gag tcc ctg gcc tcc atc cct     2448
 Ile Ser Arg Pro His Pro Thr Val Gly Glu Ser Leu Ala Ser Ile Pro
                 805                 810                 815

 caa ccc gtg acg gcg gtc ccc gga acg ggc ctt cag gca ggg ggc agg     2496
 Gln Pro Val Thr Ala Val Pro Gly Thr Gly Leu Gln Ala Gly Gly Arg
             820                 825                 830

 agc act gtc ccg cag cgc gtc acc ctc ttc cga cag atg tcg tcg gga     2544
 Ser Thr Val Pro Gln Arg Val Thr Leu Phe Arg Gln Met Ser Ser Gly
         835                 840                 845

 gcc atc ccc ccg aac cga gga gtc cct cca gca ccc cct cca cca gca     2592
 Ala Ile Pro Pro Asn Arg Gly Val Pro Pro Ala Pro Pro Pro Pro Ala
     850                 855                 860

 gct gct ctt cca aga gaa tct tcc tca gtc tta aac aca gac cca gac     2640
 Ala Ala Leu Pro Arg Glu Ser Ser Ser Val Leu Asn Thr Asp Pro Asp
 865                 870                 875                 880

 gca gaa aag cca cga ttt gct tca aat tta tga tccctgct gattgtcaaa     2691
 Ala Glu Lys Pro Arg Phe Ala Ser Asn Leu 
                 885                 890

 gcagaaagaa atactctcat aaactgagac tatactcaga tcttatttta ttctatctcc   2751

 tgatagatcc ctctagccta ctatgaagag atattttaga cagctgtggc ctacacgtga   2811

 aatgtaaaaa tatatataca tatactataa aatatatatc taaattccca agagagggtc   2871

 aaaagacctg tttagcattc agtgttatat gtcttccttt ctttaaatca ttaaaggatt   2931

 taaaatgtcg ttgtaagatt atttatttct aacctacttt tacttaagtc ctttgatatg   2991

 tatatttctc tattttatga agagttcttg gattcaatgg aaacaaaact gattttaaaa   3051

 aggcaactca aatgaactag taaatagcac caatcaaaac tttctttcat tagctgtgtc   3111

 tctgcatcta aattgttaat cattaatggt ggagaattaa ataacaaatc ccattttata   3171

 gatctaaatt gtatttcggt gctttcaatt tcaaattagg ttaaagaatg cac          3224




      <210> 237
      <211> 2001
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (944)..(1561)

      <400> 237
 ctgaacgacc atttcgtgag aaggaaaccc aggctcggag aaggggcggt tcctgctaaa     60

 gattgcacag ccaatggagg gcagagcaga attgggaccc aaggctgggg gcccccagtt    120

 ggaagctccc tccagcaagc tggccctgac acctggagcc ccagctgcca gcctgggagg    180

 ggctgggacc caatctcccc caagattagg ccggggatgt ctcccacctt cactctgaca    240

 tcccagaccc cgacccccca gccacgcagg aagggggatc tgagtgtgga acacacgggt    300

 gccctcggag gtctgatgtc acccccttcc ccaggccttg ttgctggtgg cggccttggc    360

 gggcctgggc ttgggcctga gcctcatttt catcgctgtc tacctcatcc gcttctgctg    420

 ctgccggccc cccgagcccc ccgggtccaa gatcccctcg cccgggggag gctgcgtcac    480

 ctggagctgc attgtcgccc ttctcgccgg ctgcactggc attggcatcg gtttctatgg    540

 caacagtgag accagtgatg gggtgtccca gctcagctct gcgctgctgc acgccaacca    600

 cacactcagc accattgacc acctggtgtt ggagacggtg gagaggctgg gcgaggcggt    660

 gaggacagag ctgaccaccc tggaggaggt gctcgagccg cgcacggagc tggtggctgc    720

 cgcccgaggg gctcgacggc aggcggaggc tgcggcccag cagctgcagg ggctggcctt    780

 ctggcaggga gtgcccctga gccccctgca ggtggctgaa aatgtgtcct ttgtggagga    840

 gtacaggtgg ctggcctacg tcctcctgct gctcctggag ctgctggtct gcctcttcac    900

 cctcctgggc ctggcgaagc agagcaagtg gctggtgatc gtg  atg aca gtc atg     955
                                                  Met Thr Val Met
                                                    1

 agt ctc ctg gtt ctc gtc ctg agc tgg ggc tcc atg ggc ctg gag gca     1003
 Ser Leu Leu Val Leu Val Leu Ser Trp Gly Ser Met Gly Leu Glu Ala
   5                  10                  15                  20

 gcc acg gcc gtg ggc ctc agt gac ttc tgc tcc aat cca gac cct tat     1051
 Ala Thr Ala Val Gly Leu Ser Asp Phe Cys Ser Asn Pro Asp Pro Tyr
                  25                  30                  35

 gtt ctg aac ctg acc cag gag gag aca ggg ctc agc tca gac atc ctg     1099
 Val Leu Asn Leu Thr Gln Glu Glu Thr Gly Leu Ser Ser Asp Ile Leu
              40                  45                  50

 agc tat tat ctc ctc tgc aac cgg gcc gtc tcc aac ccc ttc caa cag     1147
 Ser Tyr Tyr Leu Leu Cys Asn Arg Ala Val Ser Asn Pro Phe Gln Gln
          55                  60                  65

 agg ctg act ctg tcc cag cga gct ctg gcc aac atc cac tcc cag ctg     1195
 Arg Leu Thr Leu Ser Gln Arg Ala Leu Ala Asn Ile His Ser Gln Leu
      70                  75                  80

 ctg ggc ctg gag cga gaa gct gtg cct cag ttc cct tca gcg cag aag     1243
 Leu Gly Leu Glu Arg Glu Ala Val Pro Gln Phe Pro Ser Ala Gln Lys
  85                  90                  95                 100

 cct ctg ctg tcc ttg gag gag act ctg aat gtg aca gaa gga aat ttc     1291
 Pro Leu Leu Ser Leu Glu Glu Thr Leu Asn Val Thr Glu Gly Asn Phe
                 105                 110                 115

 cac cag ttg gtg gca ctg cta cac tgc cgc agc ctg cac aag gac tat     1339
 His Gln Leu Val Ala Leu Leu His Cys Arg Ser Leu His Lys Asp Tyr
             120                 125                 130

 ggt gca gcc ctg cgg ggc ctg tgc gaa gac gcc ctg gaa ggc ctg ctc     1387
 Gly Ala Ala Leu Arg Gly Leu Cys Glu Asp Ala Leu Glu Gly Leu Leu
         135                 140                 145

 ttc ctg cta ctc ttc tcc ctg ctg tct gca gga gcg ctg gcc act gcc     1435
 Phe Leu Leu Leu Phe Ser Leu Leu Ser Ala Gly Ala Leu Ala Thr Ala
     150                 155                 160

 ctc tgc agc ctg ccc cga gcc tgg gcc ctc ttc cca ccc agt gac gac     1483
 Leu Cys Ser Leu Pro Arg Ala Trp Ala Leu Phe Pro Pro Ser Asp Asp
 165                 170                 175                 180

 tac gat gac aca gac gat gac gac cct ttc aac cct cag gaa tcc aag     1531
 Tyr Asp Asp Thr Asp Asp Asp Asp Pro Phe Asn Pro Gln Glu Ser Lys
                 185                 190                 195

 cgc ttt gtg cag tgg cag tcg tct atc tga g cccctcctcc cggctggact     1582
 Arg Phe Val Gln Trp Gln Ser Ser Ile 
             200                 205

 ggagcctggc tcccctcttc gttccttccc tggctgccgg aggagacccc actaacccag   1642

 cctgcctggg ctctgaccac taacactctt ggccatggac agcctgcaca ggaccgcctc   1702

 cctgctcttg gccactgtgc tcccatttct gtccttggcc ttgggagtag ctgagggggc   1762

 agactaggga gtagggctgg caggggaggg ggcagacagc ctcgcctcgc acccttcatc   1822

 cctggctgcc ggtcccatcc ttggagggac taagctgggg gtgggggaca tgagtccccc   1882

 tgctgcccct gccacatccc agtgggctct gaccccctga tctcaactcg tggcactaac   1942

 ttggaaaagg gttgatttaa aataaaaggg aagactattt tacaagcaaa aaaaaaaaa    2001




      <210> 238
      <211> 1929
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (242)..(1039)

      <220>
      <221> misc_feature
      <222> (1)...(1929)
      <223> n = a,t,c or g

      <400> 238
 tttcgtgccg ggaggaggag agccccagag agaggagctg ggagcggagg cgcaggcaat     60

 gctcagccct ggatgtagct gagaggctgg gagaagagac gaccgctgga gaccgagcgg    120

 cgtggggaag acctaggggg gtgggtgggg gaagcagaca ggagaacact cgaaatcaag    180

 cgctttacag attattttat tttgtataga gaacacgtag cgactccgaa gatcagcccc    240

 a    atg aac atg tca gtg ttg act tta caa gaa tat gaa ttc gaa aag     286
      Met Asn Met Ser Val Leu Thr Leu Gln Glu Tyr Glu Phe Glu Lys
        1               5                  10                  15

 cag ttc aac gag aat gaa gcc atc caa tgg atg cag gaa aac tgg aag      334
 Gln Phe Asn Glu Asn Glu Ala Ile Gln Trp Met Gln Glu Asn Trp Lys
                  20                  25                  30

 aaa tct ttc ctg ttt tct gct ctg tat gct gcc ttt ata ttc ggt ggt      382
 Lys Ser Phe Leu Phe Ser Ala Leu Tyr Ala Ala Phe Ile Phe Gly Gly
              35                  40                  45

 cgg cac cta atg aat aaa cga gca aag ttt gaa ctg agg aag cca tta      430
 Arg His Leu Met Asn Lys Arg Ala Lys Phe Glu Leu Arg Lys Pro Leu
          50                  55                  60

 gtg ctc tgg tct ctg acc ctt gcg gtc ttc agt ata ttc ggt gct ctt      478
 Val Leu Trp Ser Leu Thr Leu Ala Val Phe Ser Ile Phe Gly Ala Leu
      65                  70                  75

 cga act ggt gct tat atg gtg tac att ttg atg acc aaa ggc ctg aag      526
 Arg Thr Gly Ala Tyr Met Val Tyr Ile Leu Met Thr Lys Gly Leu Lys
  80                  85                  90                  95

 cag tca gtt tgt gac cag ggt ttt tac aat gga cct gtc agc aaa ttc      574
 Gln Ser Val Cys Asp Gln Gly Phe Tyr Asn Gly Pro Val Ser Lys Phe
                 100                 105                 110

 tgg gct tat gca ttt gtg cta agc aaa gca ccc gaa cta gga gat aca      622
 Trp Ala Tyr Ala Phe Val Leu Ser Lys Ala Pro Glu Leu Gly Asp Thr
             115                 120                 125

 ata ttc att att ctg agg aag cag aag ctg atc ttc ctg cac tgg tat      670
 Ile Phe Ile Ile Leu Arg Lys Gln Lys Leu Ile Phe Leu His Trp Tyr
         130                 135                 140

 cac cac atc act gtg ctc ctg tac tct tgg tac tcc tac aaa gac atg      718
 His His Ile Thr Val Leu Leu Tyr Ser Trp Tyr Ser Tyr Lys Asp Met
     145                 150                 155

 gtt gcc ggg gga ggt tgg ttc atg act atg aac tat ggc gtg cac gcc      766
 Val Ala Gly Gly Gly Trp Phe Met Thr Met Asn Tyr Gly Val His Ala
 160                 165                 170                 175

 gtg atg tac tct tac tat gcc ttg cgg gcg gca ggt ttc cga gtc tcc      814
 Val Met Tyr Ser Tyr Tyr Ala Leu Arg Ala Ala Gly Phe Arg Val Ser
                 180                 185                 190

 cgg aag ttt gcc atg ttc atc acc ttg tcc cag atc act cag atg ctg      862
 Arg Lys Phe Ala Met Phe Ile Thr Leu Ser Gln Ile Thr Gln Met Leu
             195                 200                 205

 atg ggc tgt gtg gtt aac tac ctg gtc ttc tgc tgg atg cag cat gac      910
 Met Gly Cys Val Val Asn Tyr Leu Val Phe Cys Trp Met Gln His Asp
         210                 215                 220

 cag tgt cac tct cac ttt cag aac atc ttc tgg tcc tca ctc atg tac      958
 Gln Cys His Ser His Phe Gln Asn Ile Phe Trp Ser Ser Leu Met Tyr
     225                 230                 235

 ctc agc tac ctt gtg ctc ttc tgc cat ttc ttc ttt gag gcc tac atc     1006
 Leu Ser Tyr Leu Val Leu Phe Cys His Phe Phe Phe Glu Ala Tyr Ile
 240                 245                 250                 255

 ggc aaa atg agg aaa aca acg aaa gct gaa tag tgttggaa ctgaggagga     1057
 Gly Lys Met Arg Lys Thr Thr Lys Ala Glu 
                 260                 265

 agccatagct cagggtcatc aagaaaaata atagacaaaa gaaaatggca caaggaatca   1117

 cacgtggtgc agctaaaaca aaacaaaaca tgagcaaaca caaaacccaa ggcagcttag   1177

 ggataattag gttgatttaa cccagtaagt ttatgatcct tttagggtga ggactcactg   1237

 agtgcacctc catctccaag cactgctgct ggaagacccc attccctctt tatctatcaa   1297

 ctctaggaca agggagaaca aaagcaagcc agaagcagag gagactaatc aaaggcaaac   1357

 aaaggctatt aacacatagg aaaaaatgta tttactaagt gtcacatttc tctaagatga   1417

 aagattttta ctctagaaac tgtgcgagca caacacacac aatcctttct aactttatgg   1477

 acactaaact ggagccaata gaaaagacaa aaatgaaaga gacacagggt gtatatctag   1537

 acgataatgc ttttgcagga actaaagcat ttttaagaaa tgccagctgc tgtaggcccc   1597

 atgagaaaag atgtcttaat catccttatt gaaacagatg tanaccacta tatttcnaca   1657

 tacttcatct tcactgcata gctcaggtag gtgagtttgc caaaacccaa gggggggtga   1717

 ttctttcccc naggttcttc ctgggganga ttggggacag tgcaggcccg ggtcccttgg   1777

 gggtagctcc ctcccaggag gtttcttgat tggttgactg ttatttcttc tcttttggtg   1837

 aggttagggg gtattccttt tgttcagttt cccccggttt ttgaccggag gggtaatcca   1897

 ggtttgaaaa ggttacactt acccacatta gt                                 1929




      <210> 239
      <211> 3273
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (388)..(2994)

      <400> 239
 gtcagatttt aaaggtatca ataagctaaa gtctaagaac tattctagag caagaatttc     60

 tgtgagaaca caggtatagt gttgctggtc tgagatatat gcatatataa ttttgatggt    120

 tattccagtt tacataccaa ccagtagtgc atgagggctt ctgtgttaaa taactttaga    180

 agacttgttg gtagttattt ttgagagact aaatctcact ttttatttgt tttaaagtat    240

 gtaaaatttt agagcctttt tccatgattg gttctcttca gtctaaattg ttttctttgt    300

 attgtgtgaa caatctttaa atttggagaa tatttaattt tagagtgact ttttgcctaa    360

 aatcagatta atatttgcgt gtatttt    atg tta cag ggg tta gaa tac tgt     411
                                  Met Leu Gln Gly Leu Glu Tyr Cys
                                    1               5

 gaa gaa aga tac acc ctg gac ctg aca ggt ggc atg ttc cct ttg agg      459
 Glu Glu Arg Tyr Thr Leu Asp Leu Thr Gly Gly Met Phe Pro Leu Arg
      10                  15                  20

 gga cag acg agt aat acc aaa ttg ttg gga tgc cag agt ata gag aaa      507
 Gly Gln Thr Ser Asn Thr Lys Leu Leu Gly Cys Gln Ser Ile Glu Lys
  25                  30                  35                  40

 ttt cga tct cat ggt gac agg gag gaa ggc gtg aat gaa gct atg gct      555
 Phe Arg Ser His Gly Asp Arg Glu Glu Gly Val Asn Glu Ala Met Ala
                  45                  50                  55

 gat gtc ctt ggt gat ggt gga aac tcc tcg ctc act atc tct gaa ggt      603
 Asp Val Leu Gly Asp Gly Gly Asn Ser Ser Leu Thr Ile Ser Glu Gly
              60                  65                  70

 cct att gtc tct gag cgc agg ctt aac cag gaa gta gcg ctg aac tta      651
 Pro Ile Val Ser Glu Arg Arg Leu Asn Gln Glu Val Ala Leu Asn Leu
          75                  80                  85

 aaa gaa gat cat gaa gta gaa gtt ggt gta cta aaa gaa agt gtt gac      699
 Lys Glu Asp His Glu Val Glu Val Gly Val Leu Lys Glu Ser Val Asp
      90                  95                 100

 tta cca gaa gaa aag ctt cca att tct gac agc cct cct gat act caa      747
 Leu Pro Glu Glu Lys Leu Pro Ile Ser Asp Ser Pro Pro Asp Thr Gln
 105                 110                 115                 120

 gaa att cat gtg att gaa caa gaa aag ctt gaa gct caa gat tca gga      795
 Glu Ile His Val Ile Glu Gln Glu Lys Leu Glu Ala Gln Asp Ser Gly
                 125                 130                 135

 gaa gag gct agg aat ctt tca ttt aat gag tta tat ccc tct gga aca      843
 Glu Glu Ala Arg Asn Leu Ser Phe Asn Glu Leu Tyr Pro Ser Gly Thr
             140                 145                 150

 ctt aag ctt cag tac aat ttt gat act att gac caa cag ttt tgt gac      891
 Leu Lys Leu Gln Tyr Asn Phe Asp Thr Ile Asp Gln Gln Phe Cys Asp
         155                 160                 165

 tta gct gat aac aaa gac act gct gaa tgt gac att gct gaa gta gat      939
 Leu Ala Asp Asn Lys Asp Thr Ala Glu Cys Asp Ile Ala Glu Val Asp
     170                 175                 180

 ggg gaa ctt ttt gtg gct caa agc aac ttt acc ttg ata ttg gaa ggt      987
 Gly Glu Leu Phe Val Ala Gln Ser Asn Phe Thr Leu Ile Leu Glu Gly
 185                 190                 195                 200

 gaa gaa gga gaa gtt gag cca ggt gat ttt gca tca tct gat gtg tta     1035
 Glu Glu Gly Glu Val Glu Pro Gly Asp Phe Ala Ser Ser Asp Val Leu
                 205                 210                 215

 cct aaa gca gct aac aca gca act gaa gaa aaa ctt gta tgc agt ggg     1083
 Pro Lys Ala Ala Asn Thr Ala Thr Glu Glu Lys Leu Val Cys Ser Gly
             220                 225                 230

 gaa aat gat aat cat gga caa att gca aat ttg cca tct gcc gta act     1131
 Glu Asn Asp Asn His Gly Gln Ile Ala Asn Leu Pro Ser Ala Val Thr
         235                 240                 245

 agt gac caa aag tcc caa aaa gta gac act tta cca tat gtg cct gaa     1179
 Ser Asp Gln Lys Ser Gln Lys Val Asp Thr Leu Pro Tyr Val Pro Glu
     250                 255                 260

 cct att aaa gta gca att gca gaa aat tta cta gat gta att aaa gac     1227
 Pro Ile Lys Val Ala Ile Ala Glu Asn Leu Leu Asp Val Ile Lys Asp
 265                 270                 275                 280

 aca aga agt aaa gaa att act tca gat aca atg gaa cag tcc att cat     1275
 Thr Arg Ser Lys Glu Ile Thr Ser Asp Thr Met Glu Gln Ser Ile His
                 285                 290                 295

 gaa aca ata cct tta gtg agc caa aac ata atg tgt ccc act aaa ttg     1323
 Glu Thr Ile Pro Leu Val Ser Gln Asn Ile Met Cys Pro Thr Lys Leu
             300                 305                 310

 gtc aaa tct gca ttt aag act gct cag gaa aca agc aca atg act atg     1371
 Val Lys Ser Ala Phe Lys Thr Ala Gln Glu Thr Ser Thr Met Thr Met
         315                 320                 325

 aat gtc agc cag gtt gat gac gtg gtt tcc tcc aaa act cgt acg aga     1419
 Asn Val Ser Gln Val Asp Asp Val Val Ser Ser Lys Thr Arg Thr Arg
     330                 335                 340

 ggt caa cgt atc caa aac gtg aat gtc aaa tca gca caa cag gaa gca     1467
 Gly Gln Arg Ile Gln Asn Val Asn Val Lys Ser Ala Gln Gln Glu Ala
 345                 350                 355                 360

 tca gca gat gtt gct act cct aag atg cca ggg cag tca gtc agg aag     1515
 Ser Ala Asp Val Ala Thr Pro Lys Met Pro Gly Gln Ser Val Arg Lys
                 365                 370                 375

 aaa act agg aag gca aaa gaa att tct gaa gct tct gaa aac atc tat     1563
 Lys Thr Arg Lys Ala Lys Glu Ile Ser Glu Ala Ser Glu Asn Ile Tyr
             380                 385                 390

 tct gat gtc aga gga cta tct cag aac cag caa ata cct caa aat tct     1611
 Ser Asp Val Arg Gly Leu Ser Gln Asn Gln Gln Ile Pro Gln Asn Ser
         395                 400                 405

 gtt acg cct agg aga gga agg aga aag aaa gaa gtt aat cag gac ata     1659
 Val Thr Pro Arg Arg Gly Arg Arg Lys Lys Glu Val Asn Gln Asp Ile
     410                 415                 420

 cta gaa aac acc agt tct gtg gaa caa gaa tta cag atc act aca ggt     1707
 Leu Glu Asn Thr Ser Ser Val Glu Gln Glu Leu Gln Ile Thr Thr Gly
 425                 430                 435                 440

 agg gaa tca aaa aga tta aaa tca tct cag ctg ttg gaa cca gca gtt     1755
 Arg Glu Ser Lys Arg Leu Lys Ser Ser Gln Leu Leu Glu Pro Ala Val
                 445                 450                 455

 gaa gaa act act aaa aaa gaa gtt aag gtt tca tct gtt aca aaa agg     1803
 Glu Glu Thr Thr Lys Lys Glu Val Lys Val Ser Ser Val Thr Lys Arg
             460                 465                 470

 act cct aga aga att aaa aga tct gta gaa aat cag gaa agt gtt gaa     1851
 Thr Pro Arg Arg Ile Lys Arg Ser Val Glu Asn Gln Glu Ser Val Glu
         475                 480                 485

 att ata aat gat cta aaa gtt agt acg gta aca agt cct agc aga atg     1899
 Ile Ile Asn Asp Leu Lys Val Ser Thr Val Thr Ser Pro Ser Arg Met
     490                 495                 500

 atc aga aaa ttg aga agt act aat tta gat gct tct gaa aat aca gga     1947
 Ile Arg Lys Leu Arg Ser Thr Asn Leu Asp Ala Ser Glu Asn Thr Gly
 505                 510                 515                 520

 aat aag caa gat gat aaa tcc agt gac aag cag ctg cgt att aaa cat     1995
 Asn Lys Gln Asp Asp Lys Ser Ser Asp Lys Gln Leu Arg Ile Lys His
                 525                 530                 535

 gtt aga agg gtc aga ggg aga gaa gtt agt cca tca gat gtg aga gaa     2043
 Val Arg Arg Val Arg Gly Arg Glu Val Ser Pro Ser Asp Val Arg Glu
             540                 545                 550

 gac tcc aac ctt gag tca tct cag ttg act gtt caa gca gaa ttt gat     2091
 Asp Ser Asn Leu Glu Ser Ser Gln Leu Thr Val Gln Ala Glu Phe Asp
         555                 560                 565

 atg tct gcc ata cct aga aaa cgt ggt aga cca aga aaa atc aat cca     2139
 Met Ser Ala Ile Pro Arg Lys Arg Gly Arg Pro Arg Lys Ile Asn Pro
     570                 575                 580

 tct gaa gat gta gga tct aag gct gtt aag gaa gag aga agc ccc aag     2187
 Ser Glu Asp Val Gly Ser Lys Ala Val Lys Glu Glu Arg Ser Pro Lys
 585                 590                 595                 600

 aag aaa gaa gct ccc agc att aga agg aga tct aca aga aat acc cca     2235
 Lys Lys Glu Ala Pro Ser Ile Arg Arg Arg Ser Thr Arg Asn Thr Pro
                 605                 610                 615

 gct aaa agt gaa aat gtt gat gtt gga aaa cca gct tta gga aaa tcc     2283
 Ala Lys Ser Glu Asn Val Asp Val Gly Lys Pro Ala Leu Gly Lys Ser
             620                 625                 630

 att tta gtg cca aac gag gaa ctt tcg atg gtg atg agc tct aag aaa     2331
 Ile Leu Val Pro Asn Glu Glu Leu Ser Met Val Met Ser Ser Lys Lys
         635                 640                 645

 aaa ctt aca aaa aag act gaa agt caa agc caa aaa cgt tca ttg cac     2379
 Lys Leu Thr Lys Lys Thr Glu Ser Gln Ser Gln Lys Arg Ser Leu His
     650                 655                 660

 tca gta tca gaa gaa cgc aca gat gaa atg aca cat aaa gaa aca aat     2427
 Ser Val Ser Glu Glu Arg Thr Asp Glu Met Thr His Lys Glu Thr Asn
 665                 670                 675                 680

 gag cag gaa gaa aga ttg ctc gcc aca gct tcc ttc act aaa tca tcc     2475
 Glu Gln Glu Glu Arg Leu Leu Ala Thr Ala Ser Phe Thr Lys Ser Ser
                 685                 690                 695

 cgc agc agc agg act cgg tct agc aag gcc atc ttg ttg ccg gac ctt     2523
 Arg Ser Ser Arg Thr Arg Ser Ser Lys Ala Ile Leu Leu Pro Asp Leu
             700                 705                 710

 tct gaa cca aac aat gag cct tta ttt tct cca gcg tca gaa gtt cca     2571
 Ser Glu Pro Asn Asn Glu Pro Leu Phe Ser Pro Ala Ser Glu Val Pro
         715                 720                 725

 agg aaa gca aaa gct aaa aaa ata gag gtt cct gca cag ctg aaa gaa     2619
 Arg Lys Ala Lys Ala Lys Lys Ile Glu Val Pro Ala Gln Leu Lys Glu
     730                 735                 740

 tta gtt tcg gat tta tct tct cag ttt gtc atc tca cct cct gct tta     2667
 Leu Val Ser Asp Leu Ser Ser Gln Phe Val Ile Ser Pro Pro Ala Leu
 745                 750                 755                 760

 agg agc aga caa aaa aac aca tcc aat aag aac aag ctt gaa gat gaa     2715
 Arg Ser Arg Gln Lys Asn Thr Ser Asn Lys Asn Lys Leu Glu Asp Glu
                 765                 770                 775

 ctg aaa gat gat gca caa tca gta gaa act ctg gga aag cca aaa gcg     2763
 Leu Lys Asp Asp Ala Gln Ser Val Glu Thr Leu Gly Lys Pro Lys Ala
             780                 785                 790

 aaa cga atc agg acg tca aaa aca aaa caa gca agc aaa aac aca gaa     2811
 Lys Arg Ile Arg Thr Ser Lys Thr Lys Gln Ala Ser Lys Asn Thr Glu
         795                 800                 805

 aaa gaa agt gct tgg tca cct cct ccc ata gaa att cgg ctg att tcc     2859
 Lys Glu Ser Ala Trp Ser Pro Pro Pro Ile Glu Ile Arg Leu Ile Ser
     810                 815                 820

 ccc ttg gct agc cca gct gac gga gtc aag agc aaa cca aga aaa act     2907
 Pro Leu Ala Ser Pro Ala Asp Gly Val Lys Ser Lys Pro Arg Lys Thr
 825                 830                 835                 840

 aca gaa gtg aca gga aca ggt ctt gga agg aac aga aag aaa ctg tct     2955
 Thr Glu Val Thr Gly Thr Gly Leu Gly Arg Asn Arg Lys Lys Leu Ser
                 845                 850                 855

 tcc tat cca aag caa att tta cgc aga aaa atg ctg taa tttcttggga      3004
 Ser Tyr Pro Lys Gln Ile Leu Arg Arg Lys Met Leu 
             860                 865

 agattttaat gtacacctat ttgtaaagtc atcagaatag tgtggattat taaatatcta   3064

 gtttggaaga aaataattta tataaattat tgtaaatttt tatgtaaaca gaaggtcttc   3124

 aataagtaaa gtaactccat atggagtgat tgtttcagtc caggcaattt ttctatttta   3184

 tattaagact tcatacattt atatatgtaa atatggctta ttaatggaat gttaaataaa   3244

 atgtatactt cacagtcaaa aaaaaaaaa                                     3273




      <210> 240
      <211> 1669
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (395)..(1615)

      <400> 240
 ggagcggctg ccacggaaaa cgcctggccg gacggtggct ggcggccctg cctgggcgcg     60

 gagggcggcg gtggcgggcc ccgcggcctt ctctcagctt cctttctcct cacgacggcc    120

 tccacagtcc ggagcccggc ggagcccgga cctggcgggg agagctgcct ccacggccgg    180

 gcacccagac cccaccgtcg cagtcgccac cacctcagtc catccttggt accggcaatg    240

 ggcttcgtat cctccagtgc acttgtaact gacttggaca cggaatacta agaactcact    300

 tctgtcctca tcccagtcgc gccggcggtg accatctcgg ctcttttggg cttaactgcc    360

 gctcctctgg actctgtctg actttggggg cacc    atg gac caa agt ggg atg     412
                                          Met Asp Gln Ser Gly Met
                                            1               5

 gag att cct gtg acc ctc atc att aaa gca ccg aat cag aaa tac agt      460
 Glu Ile Pro Val Thr Leu Ile Ile Lys Ala Pro Asn Gln Lys Tyr Ser
              10                  15                  20

 gac cag act att agc tgc ttc ttg aac tgg acc gtg ggg aaa cta aaa      508
 Asp Gln Thr Ile Ser Cys Phe Leu Asn Trp Thr Val Gly Lys Leu Lys
          25                  30                  35

 acg cat cta tct aac gtt tac cct agc aaa cca ttg acg aag gat cag      556
 Thr His Leu Ser Asn Val Tyr Pro Ser Lys Pro Leu Thr Lys Asp Gln
      40                  45                  50

 aga ttg gtg tat tcg ggc aga ctg ctt ccc gat cat ctg cag ctg aaa      604
 Arg Leu Val Tyr Ser Gly Arg Leu Leu Pro Asp His Leu Gln Leu Lys
  55                  60                  65                  70

 gac att ctc aga aaa caa gat gag tat cat atg gtt cat cta gta tgt      652
 Asp Ile Leu Arg Lys Gln Asp Glu Tyr His Met Val His Leu Val Cys
                  75                  80                  85

 act tct cgg act cct ccc agt tct cca aaa tcc agc acc aat aga gaa      700
 Thr Ser Arg Thr Pro Pro Ser Ser Pro Lys Ser Ser Thr Asn Arg Glu
              90                  95                 100

 agt cat gaa gca ttg aca tcc agc agc aat tct agt tca gat cat tca      748
 Ser His Glu Ala Leu Thr Ser Ser Ser Asn Ser Ser Ser Asp His Ser
         105                 110                 115

 gga tca aca act cca tca tct ggt caa gaa acc ttg tct tta gct gtg      796
 Gly Ser Thr Thr Pro Ser Ser Gly Gln Glu Thr Leu Ser Leu Ala Val
     120                 125                 130

 ggt tct tcc tca gaa gga ttg agg cag cgt acc ctt cca caa gca caa      844
 Gly Ser Ser Ser Glu Gly Leu Arg Gln Arg Thr Leu Pro Gln Ala Gln
 135                 140                 145                 150

 act gac caa gca cag agt cac cag ttt cca tat gta atg caa gga aat      892
 Thr Asp Gln Ala Gln Ser His Gln Phe Pro Tyr Val Met Gln Gly Asn
                 155                 160                 165

 gta gac aac caa ttt cct ggg caa gct gct cca cct gga ttc cca gtg      940
 Val Asp Asn Gln Phe Pro Gly Gln Ala Ala Pro Pro Gly Phe Pro Val
             170                 175                 180

 tat ccc gcg ttt agc cca ctg cag atg cta tgg tgg caa cag atg tat      988
 Tyr Pro Ala Phe Ser Pro Leu Gln Met Leu Trp Trp Gln Gln Met Tyr
         185                 190                 195

 gct cat cag tat tat atg cag tat caa gct gca gtt tca gct cag gcc     1036
 Ala His Gln Tyr Tyr Met Gln Tyr Gln Ala Ala Val Ser Ala Gln Ala
     200                 205                 210

 aca tca aat gtc aac cca acc cag cct act act tca cag cct cta aat     1084
 Thr Ser Asn Val Asn Pro Thr Gln Pro Thr Thr Ser Gln Pro Leu Asn
 215                 220                 225                 230

 ttg gca cat gtt cct gga gaa gaa ccc cca cca gct cca aac cta gtg     1132
 Leu Ala His Val Pro Gly Glu Glu Pro Pro Pro Ala Pro Asn Leu Val
                 235                 240                 245

 gcc caa gaa aat cga ccc atg aat gag aat gtt caa atg aat gca cag     1180
 Ala Gln Glu Asn Arg Pro Met Asn Glu Asn Val Gln Met Asn Ala Gln
             250                 255                 260

 gga ggt cca gta cta aat gaa gaa gac ttc aat cga gac tgg cta gac     1228
 Gly Gly Pro Val Leu Asn Glu Glu Asp Phe Asn Arg Asp Trp Leu Asp
         265                 270                 275

 tgg atg tac acg ttc tca cga gct gcg att ctc ctt agc att gta tac     1276
 Trp Met Tyr Thr Phe Ser Arg Ala Ala Ile Leu Leu Ser Ile Val Tyr
     280                 285                 290

 ttc tat tct tct ttt agt cgg ttt atc atg gta atg gga gcc atg cta     1324
 Phe Tyr Ser Ser Phe Ser Arg Phe Ile Met Val Met Gly Ala Met Leu
 295                 300                 305                 310

 ctg gtt tat tta cac caa gct gga tgg ttt cct ttt agg caa gaa gga     1372
 Leu Val Tyr Leu His Gln Ala Gly Trp Phe Pro Phe Arg Gln Glu Gly
                 315                 320                 325

 ggt cat cag cag gct ccc aac aat aat gcc gaa gtt aac aat gat ggg     1420
 Gly His Gln Gln Ala Pro Asn Asn Asn Ala Glu Val Asn Asn Asp Gly
             330                 335                 340

 caa aat gca aac aac ttg gaa ctt gaa gaa atg gag cgt ctt atg gat     1468
 Gln Asn Ala Asn Asn Leu Glu Leu Glu Glu Met Glu Arg Leu Met Asp
         345                 350                 355

 gat ggg ctt gaa gat gag agt gga gaa gat gga ggt gaa gat gcc agt     1516
 Asp Gly Leu Glu Asp Glu Ser Gly Glu Asp Gly Gly Glu Asp Ala Ser
     360                 365                 370

 gca att caa agg cct gga tta atg gct tca gct tgg tct ttc atc acc     1564
 Ala Ile Gln Arg Pro Gly Leu Met Ala Ser Ala Trp Ser Phe Ile Thr
 375                 380                 385                 390

 acc ttc ttt act tca cta ata cca gag ggg cct ccc cag gtt gcc aat     1612
 Thr Phe Phe Thr Ser Leu Ile Pro Glu Gly Pro Pro Gln Val Ala Asn
                 395                 400                 405

 tga cctg aaaaactgtg ccagctacaa ggagggtctg acttcaggaa agtggtttaa     1669
 






      <210> 241
      <211> 3164
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1343)

      <400> 241
 tttcgtgccg cttccggggt cgggcgcctg gatagctgcc ggctccggct tccacttggt     60

 cggttgcgcg ggagact   atg gcg tcc tcc tcg gtc cca cca gcc acg gta     110
                      Met Ala Ser Ser Ser Val Pro Pro Ala Thr Val
                        1               5                  10

 tcg gcg gcg aca gca ggc ccc ggc cca ggt ttc ggc ttc gcc tcc aag      158
 Ser Ala Ala Thr Ala Gly Pro Gly Pro Gly Phe Gly Phe Ala Ser Lys
              15                  20                  25

 acc aag aag aag cat ttc gtg cag cag aag gtg aag gtg ttc cgg gcg      206
 Thr Lys Lys Lys His Phe Val Gln Gln Lys Val Lys Val Phe Arg Ala
          30                  35                  40

 gcc gac ccg ctg gtg ggt gtg ttc ctg tgg ggc gta gcc cac tcg atc      254
 Ala Asp Pro Leu Val Gly Val Phe Leu Trp Gly Val Ala His Ser Ile
      45                  50                  55

 aat gag ctc agc cag gtg cct ccc ccg gtg atg ctg ctg cca gat gac      302
 Asn Glu Leu Ser Gln Val Pro Pro Pro Val Met Leu Leu Pro Asp Asp
  60                  65                  70                  75

 ttt aag gcc agc tcc aag atc aag gtc aac aat cac ctt ttc cac agg      350
 Phe Lys Ala Ser Ser Lys Ile Lys Val Asn Asn His Leu Phe His Arg
                  80                  85                  90

 gaa aat ctg ccc agt cat ttc aag ttc aag gag tat tgt ccc cag gtc      398
 Glu Asn Leu Pro Ser His Phe Lys Phe Lys Glu Tyr Cys Pro Gln Val
              95                 100                 105

 ttc agg aac ctc cgt gat cga ttt ggc att gat gac caa gat tac ttg      446
 Phe Arg Asn Leu Arg Asp Arg Phe Gly Ile Asp Asp Gln Asp Tyr Leu
         110                 115                 120

 gtg tcc ctt acc cga aac ccc ccc agc gaa agt gaa ggc agt gat ggt      494
 Val Ser Leu Thr Arg Asn Pro Pro Ser Glu Ser Glu Gly Ser Asp Gly
     125                 130                 135

 cgc ttc ctt atc tcc tac gat cgg act ctg gtc atc aaa gaa gta tcc      542
 Arg Phe Leu Ile Ser Tyr Asp Arg Thr Leu Val Ile Lys Glu Val Ser
 140                 145                 150                 155

 agt gag gac att gct gac atg cat agc aac ctc tcc aac tat cac cag      590
 Ser Glu Asp Ile Ala Asp Met His Ser Asn Leu Ser Asn Tyr His Gln
                 160                 165                 170

 tac att gtg aag tgc cat ggc aac acg ctt ctg ccc cag ttc ctg ggg      638
 Tyr Ile Val Lys Cys His Gly Asn Thr Leu Leu Pro Gln Phe Leu Gly
             175                 180                 185

 atg tac cga gtc agt gtg gac aac gaa gac agc tac atg ctt gtg atg      686
 Met Tyr Arg Val Ser Val Asp Asn Glu Asp Ser Tyr Met Leu Val Met
         190                 195                 200

 cgc aat atg ttt agc cac cgt ctt cct gtg cac agg aag tat gac ctc      734
 Arg Asn Met Phe Ser His Arg Leu Pro Val His Arg Lys Tyr Asp Leu
     205                 210                 215

 aag ggt tcc cta gtg tcc cgg gaa gcc agc gat aag gaa aag gtt aaa      782
 Lys Gly Ser Leu Val Ser Arg Glu Ala Ser Asp Lys Glu Lys Val Lys
 220                 225                 230                 235

 gaa ttg ccc acc ctt aag gat atg gac ttt ctc aac aag aac cag aaa      830
 Glu Leu Pro Thr Leu Lys Asp Met Asp Phe Leu Asn Lys Asn Gln Lys
                 240                 245                 250

 gta tat att ggt gaa gag gag aag aaa ata ttt ctg gag aag ctg aag      878
 Val Tyr Ile Gly Glu Glu Glu Lys Lys Ile Phe Leu Glu Lys Leu Lys
             255                 260                 265

 aga gat gtg gag ttt cta gtg cag ctg aag atc atg gac tac agc ctt      926
 Arg Asp Val Glu Phe Leu Val Gln Leu Lys Ile Met Asp Tyr Ser Leu
         270                 275                 280

 ctg cta ggc atc cac gac atc att cgg ggc tct gaa cca gag gag gaa      974
 Leu Leu Gly Ile His Asp Ile Ile Arg Gly Ser Glu Pro Glu Glu Glu
     285                 290                 295

 gcg ccc gtg cgg gag gat gag tca gag gtg gat ggg gac tgc agc ctg     1022
 Ala Pro Val Arg Glu Asp Glu Ser Glu Val Asp Gly Asp Cys Ser Leu
 300                 305                 310                 315

 act gga cct cct gct ctg gtg ggc tcc tat ggc acc tcc cca gag ggt     1070
 Thr Gly Pro Pro Ala Leu Val Gly Ser Tyr Gly Thr Ser Pro Glu Gly
                 320                 325                 330

 atc gga ggc tac atc cat tcc cat cgg ccc ctg ggc cca gga gag ttt     1118
 Ile Gly Gly Tyr Ile His Ser His Arg Pro Leu Gly Pro Gly Glu Phe
             335                 340                 345

 gag tcc ttc att gat gtc tat gcc atc cgg agt gct gaa gga gcc ccc     1166
 Glu Ser Phe Ile Asp Val Tyr Ala Ile Arg Ser Ala Glu Gly Ala Pro
         350                 355                 360

 cag aag gag gtc tac ttc atg ggc ctc att gat atc ctt aca cag tat     1214
 Gln Lys Glu Val Tyr Phe Met Gly Leu Ile Asp Ile Leu Thr Gln Tyr
     365                 370                 375

 gat gcc aag aag aaa gca gct cat gca gcc aaa act gtc aag cat ggg     1262
 Asp Ala Lys Lys Lys Ala Ala His Ala Ala Lys Thr Val Lys His Gly
 380                 385                 390                 395

 gct ggg gca gag atc tct act gtc cat ccg gag cag tat gct aag cga     1310
 Ala Gly Ala Glu Ile Ser Thr Val His Pro Glu Gln Tyr Ala Lys Arg
                 400                 405                 410

 ttc ctg gat ttt att acc aac atc ttt gcc taa gagactgc ctggttctct     1361
 Phe Leu Asp Phe Ile Thr Asn Ile Phe Ala 
             415                 420

 ctgatgttca aggtggtggg gttctgagac acttggggga attgtgggga tattctagcc   1421

 accagttctc ttcttccttt gctaaattca ggctgcaggc tccttccatc cagataactc   1481

 catcctgtcg agtaggctct ttctgaccct cagaaataca ttgtcctttt tcctctttgc   1541

 ccatttttct tccctctctt cctccccatg agaagtctgc ttgtagtatt agaatgttat   1601

 tgttgactct ctcccaagtg ccttgatctt tgtaatatct cctgttgttt ctatgatata   1661

 ggagctaggg gaagggggtt gtttgccttc ttcaggacct gactggacag atggacctgg   1721

 ctcaagcaac tactctggat gcactttgct gtgtgggatg aactaaaagt gtctgaattt   1781

 tgctgataac tttataaaac tcactatggc atgcttccct cctggtgggc cctaggatgg   1841

 atgacactca agatactaca gatgtgggtg caggcatgca cacacacgat ggaatatggc   1901

 cattcctaca caggtggggt agagagtggg tcagcagcct ggcacctcac agaggtggga   1961

 cctaagagga ctcatgatta tgcagagaat tggattgggt ctctgtcata gattgagtaa   2021

 tctcttccct tacctcaatt ccatctccac ccatctctac atctgggcac agcaacccag   2081

 agatggccaa aagcattcaa gcctggggga agatgtttga ctattgctgc tcttcaccag   2141

 aacctcacac ctctcctggg actggaaccc ttcagtgggt gtgtggccag ttttggaggc   2201

 tggaatgatg ggccagggtg taggattcat tctccatgta aagtttcctt tcatcctgcc   2261

 tagccatccc caaggtttat ttccagaaga aaggaatatc tctacttgga tcaattctgg   2321

 tcatttcaag aggatggagg cctcaagtgt gggaacttcc cctactccct ggatgtgtgt   2381

 acctagcaca cttccttctc ccaccccttt ttccagttgg atttgttttt ctgttctctt   2441

 ctgtcctgtc ttatactgca actgtgtctc ctaggggaca gatggccttc tttgtcatct   2501

 tcactctcca cccccagaga ggagtcagag ccataactca atcactcagc ccctccaaag   2561

 atagttgatg tgtgataatc tcataatgtt gagaaccctg atgagataca ttgtcttcct   2621

 ctccctacaa tgcctctggg gccaaggcac ccattcttct tgctatcctc catccccctt   2681

 gaggcttcca cttttttttt ttttagacat aaagctgggc atcagcaact ggcctgtggt   2741

 gatgcaaagc tgctttgctc tgtatctggc tggactgatc tgtctcacaa gaagccatga   2801

 ggccataggg agaagctccc tctccccttc atcttctgct ccaaaggtgg tagcaagagg   2861

 agtacccagt taggggttgg agcccccata taacatcttc ctgtcagaag actgatggat   2921

 ctttttcatt ccaaccatct ccctttcccc cgatgaatgc aataaaactc tgtgacacca   2981

 gcaaccattg ctctttagaa atgggttttc tgatcatatg gctgatgtgt tatgggcagt   3041

 atggatgtct tcatttgttg cttctgtttt tcatcttttt tgttttatta ataaaaattt   3101

 atgtatttgc tcctgttact ataataatac agggaataaa ttattcaatc caaaaaaaaa   3161

 aaa                                                                 3164




      <210> 242
      <211> 6423
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (59)..(6172)

      <220>
      <221> misc_feature
      <222> (1)...(6423)
      <223> n = a,t,c or g

      <400> 242
 cagggggcgg taagtggcgg tcgttcgcgg aagtagggct gatgagagtg tgtgttga       58                                                                 
 atg cgc gag cgg atg gac gca gat agg ggc gca agc agc tat att gag      106
 Met Arg Glu Arg Met Asp Ala Asp Arg Gly Ala Ser Ser Tyr Ile Glu
   1               5                  10                  15

 tac act gtg gtg aac cct gtg gga agc aag ttc agt att ggg acc att      154
 Tyr Thr Val Val Asn Pro Val Gly Ser Lys Phe Ser Ile Gly Thr Ile
              20                  25                  30

 gat ggt gaa gtg agg ctc gct gga gaa ctg gac aga gaa gaa gtt tct      202
 Asp Gly Glu Val Arg Leu Ala Gly Glu Leu Asp Arg Glu Glu Val Ser
          35                  40                  45

 aat tat act cta aca gtg gtg gct aca gac aaa ggt caa cca tct ctc      250
 Asn Tyr Thr Leu Thr Val Val Ala Thr Asp Lys Gly Gln Pro Ser Leu
      50                  55                  60

 tct tca tct aca gag gtt gta gtt atg gta ctt gac atc aat gat aac      298
 Ser Ser Ser Thr Glu Val Val Val Met Val Leu Asp Ile Asn Asp Asn
  65                  70                  75                  80

 aac ccc atc ttt gca caa gct ttg tat aaa gtg gag att aat gaa aac      346
 Asn Pro Ile Phe Ala Gln Ala Leu Tyr Lys Val Glu Ile Asn Glu Asn
                  85                  90                  95

 aca ctt act gga aca gat ata ata caa gtg ttc gca gca gat gga gat      394
 Thr Leu Thr Gly Thr Asp Ile Ile Gln Val Phe Ala Ala Asp Gly Asp
             100                 105                 110

 gaa ggc aca aat gga cag gtt cgc tat ggc att gtt aat ggt aat acc      442
 Glu Gly Thr Asn Gly Gln Val Arg Tyr Gly Ile Val Asn Gly Asn Thr
         115                 120                 125

 aat cag gaa ttt cgg ata gac tct gtc aca ggt gcc atc act gtc gct      490
 Asn Gln Glu Phe Arg Ile Asp Ser Val Thr Gly Ala Ile Thr Val Ala
     130                 135                 140

 aaa cct ttg gat aga gaa aag acc cct acc tac cat tta act gtt cag      538
 Lys Pro Leu Asp Arg Glu Lys Thr Pro Thr Tyr His Leu Thr Val Gln
 145                 150                 155                 160

 gca aca gat cga ggc agc aca ccc aga act gat acc tcc acg gtc agc      586
 Ala Thr Asp Arg Gly Ser Thr Pro Arg Thr Asp Thr Ser Thr Val Ser
                 165                 170                 175

 att gtt cta ctg gat att aat gac ttt gtt cct gta ttt gag cta tct      634
 Ile Val Leu Leu Asp Ile Asn Asp Phe Val Pro Val Phe Glu Leu Ser
             180                 185                 190

 cca tat tct gta aat gtc cct gag aat tta ggg aca cta ccc aga aca      682
 Pro Tyr Ser Val Asn Val Pro Glu Asn Leu Gly Thr Leu Pro Arg Thr
         195                 200                 205

 att ctt cag gtg gtg gca aga gat gat gat cga gga tct aac agc aaa      730
 Ile Leu Gln Val Val Ala Arg Asp Asp Asp Arg Gly Ser Asn Ser Lys
     210                 215                 220

 ctc tca tat gtt ctg ttt ggt ggt aat gaa gac aat gct ttt act ctc      778
 Leu Ser Tyr Val Leu Phe Gly Gly Asn Glu Asp Asn Ala Phe Thr Leu
 225                 230                 235                 240

 tca gcc agt gga gaa ctt gga gta aca cag agt ctg gat cgg gaa aca      826
 Ser Ala Ser Gly Glu Leu Gly Val Thr Gln Ser Leu Asp Arg Glu Thr
                 245                 250                 255

 aaa gag cgc ttt gtc tta atg att aca gct aca gat tca gct ttt ggg      874
 Lys Glu Arg Phe Val Leu Met Ile Thr Ala Thr Asp Ser Ala Phe Gly
             260                 265                 270

 aaa gaa att cga ttc tcc cgg ttc ccc acc acc cct tcc ccg gtg cgc      922
 Lys Glu Ile Arg Phe Ser Arg Phe Pro Thr Thr Pro Ser Pro Val Arg
         275                 280                 285

 agt tgt gct tgg acg ttt gtt cct ccc tct tca cgt tct tcg ctg cgg      970
 Ser Cys Ala Trp Thr Phe Val Pro Pro Ser Ser Arg Ser Ser Leu Arg
     290                 295                 300

 gga gcc agg acc atg gac tta gca cca gac agg gct act ggc cgc ccg     1018
 Gly Ala Arg Thr Met Asp Leu Ala Pro Asp Arg Ala Thr Gly Arg Pro
 305                 310                 315                 320

 tgg ctc ccg ttg cac act cta tca gta tct cag ctc ctt cga gtg ttt     1066
 Trp Leu Pro Leu His Thr Leu Ser Val Ser Gln Leu Leu Arg Val Phe
                 325                 330                 335

 tgg cta ctg tca ttg ctt ccg ggg cag gcc tgg gtc cac ggg gcc gag     1114
 Trp Leu Leu Ser Leu Leu Pro Gly Gln Ala Trp Val His Gly Ala Glu
             340                 345                 350

 ccg cgc cag gtg ttc caa gtg ctg gaa gag caa cct cca ggc act ctg     1162
 Pro Arg Gln Val Phe Gln Val Leu Glu Glu Gln Pro Pro Gly Thr Leu
         355                 360                 365

 gta ggc acc atc cag acg cgc ccc ggc ttc acc tac agg ctc agc gaa     1210
 Val Gly Thr Ile Gln Thr Arg Pro Gly Phe Thr Tyr Arg Leu Ser Glu
     370                 375                 380

 agc cac gcc ctg ttt gcc ata aac agt agc acc gga gcc ctg tac acc     1258
 Ser His Ala Leu Phe Ala Ile Asn Ser Ser Thr Gly Ala Leu Tyr Thr
 385                 390                 395                 400

 acc tcc acc atc gac cgc gag agc ctg ccc agc gac gtg atc aac ctg     1306
 Thr Ser Thr Ile Asp Arg Glu Ser Leu Pro Ser Asp Val Ile Asn Leu
                 405                 410                 415

 gtg gtc ctt tcc agc gcg ccc acc tac ccc acc gaa gtg cga gtg ctg     1354
 Val Val Leu Ser Ser Ala Pro Thr Tyr Pro Thr Glu Val Arg Val Leu
             420                 425                 430

 gtg cgg gac ctc aat gac aac gcc ccc gtt ttc ccg gac ccc tct atc     1402
 Val Arg Asp Leu Asn Asp Asn Ala Pro Val Phe Pro Asp Pro Ser Ile
         435                 440                 445

 gtg gtc act ttc aag gaa gac agt agc agc gga cgc caa gtc atc tta     1450
 Val Val Thr Phe Lys Glu Asp Ser Ser Ser Gly Arg Gln Val Ile Leu
     450                 455                 460

 gac acc gcc acc gac tcg gac atc ggc tca aac ggt gtg gac cac cgc     1498
 Asp Thr Ala Thr Asp Ser Asp Ile Gly Ser Asn Gly Val Asp His Arg
 465                 470                 475                 480

 tcc tac cgc atc atc cgc ggc aat gag gcg ggg cgc ttc cgt ctg gac     1546
 Ser Tyr Arg Ile Ile Arg Gly Asn Glu Ala Gly Arg Phe Arg Leu Asp
                 485                 490                 495

 atc acc ctg aac ccg agc ggc gag gga gcg ttc ctg cat ctg gtg tcc     1594
 Ile Thr Leu Asn Pro Ser Gly Glu Gly Ala Phe Leu His Leu Val Ser
             500                 505                 510

 aag ggc gga ctg gac cgt gag gtc act ccg cag tac cag ctc ctg gtt     1642
 Lys Gly Gly Leu Asp Arg Glu Val Thr Pro Gln Tyr Gln Leu Leu Val
         515                 520                 525

 gag gtg gag gac aag ggt gag cct aag cgg cgg ggc tac ctt cag gta     1690
 Glu Val Glu Asp Lys Gly Glu Pro Lys Arg Arg Gly Tyr Leu Gln Val
     530                 535                 540

 aac gtg act gtg caa gac att aat gac aac ccc ccg gtt ttt ggc agt     1738
 Asn Val Thr Val Gln Asp Ile Asn Asp Asn Pro Pro Val Phe Gly Ser
 545                 550                 555                 560

 tct cac tac cag gcg ggg gtg cct gag gac gcg gtt gtg ggt tcc agc     1786
 Ser His Tyr Gln Ala Gly Val Pro Glu Asp Ala Val Val Gly Ser Ser
                 565                 570                 575

 gtc ctc cag gtg gcg gcg gcg gac gcg gac gag ggc acc aac gcg gac     1834
 Val Leu Gln Val Ala Ala Ala Asp Ala Asp Glu Gly Thr Asn Ala Asp
             580                 585                 590

 atc cgc tat cgc ctg cag gac gag ggg acc ccc ttc caa atg gac cct     1882
 Ile Arg Tyr Arg Leu Gln Asp Glu Gly Thr Pro Phe Gln Met Asp Pro
         595                 600                 605

 gag acg gga ctt atc acg gtg cgg gag ccc ctg gac ttc gaa gct cgg     1930
 Glu Thr Gly Leu Ile Thr Val Arg Glu Pro Leu Asp Phe Glu Ala Arg
     610                 615                 620

 cgc caa tac tcg ctt acg gtg cag gcg atg gac aga ggc gtg cct tcc     1978
 Arg Gln Tyr Ser Leu Thr Val Gln Ala Met Asp Arg Gly Val Pro Ser
 625                 630                 635                 640

 ctc act ggg cgc gcc gag gcg ctg att cag ctg ctg gac gtg aat gac     2026
 Leu Thr Gly Arg Ala Glu Ala Leu Ile Gln Leu Leu Asp Val Asn Asp
                 645                 650                 655

 aat gac ccg gta gtg aag ttc cgc tac ttc ccg gcc acc tcg cgc tac     2074
 Asn Asp Pro Val Val Lys Phe Arg Tyr Phe Pro Ala Thr Ser Arg Tyr
             660                 665                 670

 gcc tcg gta gat gag aat gct caa gtg ggc acc gtg gtg gct ctg ctc     2122
 Ala Ser Val Asp Glu Asn Ala Gln Val Gly Thr Val Val Ala Leu Leu
         675                 680                 685

 acc gtg acg gac gca gat tct ccc gcg gcc aac ggg aac atc tcc gtg     2170
 Thr Val Thr Asp Ala Asp Ser Pro Ala Ala Asn Gly Asn Ile Ser Val
     690                 695                 700

 caa att ctc ggg ggc aat gag cag cgc cac ttt gaa gtg caa agc agc     2218
 Gln Ile Leu Gly Gly Asn Glu Gln Arg His Phe Glu Val Gln Ser Ser
 705                 710                 715                 720

 aaa gtg ccg aac ctg agc cta atc aag gtg gcc agc gcc ttg gac cgc     2266
 Lys Val Pro Asn Leu Ser Leu Ile Lys Val Ala Ser Ala Leu Asp Arg
                 725                 730                 735

 gag cgc atc cct tcc tac aac ctc aca gtt tcc gtc tct gat aac tac     2314
 Glu Arg Ile Pro Ser Tyr Asn Leu Thr Val Ser Val Ser Asp Asn Tyr
             740                 745                 750

 ggg gcg ccc cct ggc gca gca gtc ctg gcg cgc tct tct gtg gca agc     2362
 Gly Ala Pro Pro Gly Ala Ala Val Leu Ala Arg Ser Ser Val Ala Ser
         755                 760                 765

 ctg gtg att ttt gtt aat gac atc aat gac cat cct cct gtc ttt tca     2410
 Leu Val Ile Phe Val Asn Asp Ile Asn Asp His Pro Pro Val Phe Ser
     770                 775                 780

 cag caa gtg tac aga gtg aac ctg agc gag gag gcg cct ccg gga agc     2458
 Gln Gln Val Tyr Arg Val Asn Leu Ser Glu Glu Ala Pro Pro Gly Ser
 785                 790                 795                 800

 tat gtg agt ggg ata tct gcc act gat ggc gac tct ggt ctc aat gct     2506
 Tyr Val Ser Gly Ile Ser Ala Thr Asp Gly Asp Ser Gly Leu Asn Ala
                 805                 810                 815

 aat ctg cgt tac agc att gtc tct ggc aat gga ctg gga tgg ttc cat     2554
 Asn Leu Arg Tyr Ser Ile Val Ser Gly Asn Gly Leu Gly Trp Phe His
             820                 825                 830

 atc agt gaa cat agc ggc ctc gtg acc act ggg tcc tct ggg ggc ctg     2602
 Ile Ser Glu His Ser Gly Leu Val Thr Thr Gly Ser Ser Gly Gly Leu
         835                 840                 845

 gac cgt gaa ctt gct tcc cag att gtt ctg aat ata agt gcc cgg gac     2650
 Asp Arg Glu Leu Ala Ser Gln Ile Val Leu Asn Ile Ser Ala Arg Asp
     850                 855                 860

 cag gga gtt cac ccc aag gtg tcc tat gcc cag ctt gta gta act ctc     2698
 Gln Gly Val His Pro Lys Val Ser Tyr Ala Gln Leu Val Val Thr Leu
 865                 870                 875                 880

 cta gat gtg aat gat gaa aag cca gta ttt agc cag cca gaa ggg tat     2746
 Leu Asp Val Asn Asp Glu Lys Pro Val Phe Ser Gln Pro Glu Gly Tyr
                 885                 890                 895

 gat gtg tct gtg gtt gag aat gcc cca aca ggg aca gaa ctg ttg atg     2794
 Asp Val Ser Val Val Glu Asn Ala Pro Thr Gly Thr Glu Leu Leu Met
             900                 905                 910

 ctc agg gca act gac ggg gac ctg ggt gac aac gga aca gtg cgc ttc     2842
 Leu Arg Ala Thr Asp Gly Asp Leu Gly Asp Asn Gly Thr Val Arg Phe
         915                 920                 925

 tcc tta caa gag gca gag act gac cgg agg tcc ttc cgt ctg gat cct     2890
 Ser Leu Gln Glu Ala Glu Thr Asp Arg Arg Ser Phe Arg Leu Asp Pro
     930                 935                 940

 gtg tct ggg agg ttg agt act att tcc tcc ttg gac aga gaa gag caa     2938
 Val Ser Gly Arg Leu Ser Thr Ile Ser Ser Leu Asp Arg Glu Glu Gln
 945                 950                 955                 960

 gcc ttc tac tcc ctg ttg gtt ctg gcc aca gat ctg ggc tcc cct ccc     2986
 Ala Phe Tyr Ser Leu Leu Val Leu Ala Thr Asp Leu Gly Ser Pro Pro
                 965                 970                 975

 cag tca tca atg gct cgc ata aat gtg agt ctt ctg gat ata aat gat     3034
 Gln Ser Ser Met Ala Arg Ile Asn Val Ser Leu Leu Asp Ile Asn Asp
             980                 985                 990

 aac agc cct gtc ttc tac ccg gtc caa tac ttt gct cac att aag gag     3082
 Asn Ser Pro Val Phe Tyr Pro Val Gln Tyr Phe Ala His Ile Lys Glu
         995                1000                1005

 aat gag cct gga ggt agc tac atc acc act gtg tct gcc act gac cca     3130
 Asn Glu Pro Gly Gly Ser Tyr Ile Thr Thr Val Ser Ala Thr Asp Pro
    1010                1015                1020

 gac ttg ggt acc aat ggt act gtc aaa tat agc ata tct gct ggg gac     3178
 Asp Leu Gly Thr Asn Gly Thr Val Lys Tyr Ser Ile Ser Ala Gly Asp
1025                1030                1035                1040

 agg tct cgg ttt cag gtc aat gct cag agt ggg gtt att tct aca aga     3226
 Arg Ser Arg Phe Gln Val Asn Ala Gln Ser Gly Val Ile Ser Thr Arg
                1045                1050                1055

 atg gcc cta gac aga gaa gaa aaa aca gct tat cag ttg caa ata gta     3274
 Met Ala Leu Asp Arg Glu Glu Lys Thr Ala Tyr Gln Leu Gln Ile Val
            1060                1065                1070

 gct act gat ggt ggc aat tta caa tct ccc aac cag gca ata gta acc     3322
 Ala Thr Asp Gly Gly Asn Leu Gln Ser Pro Asn Gln Ala Ile Val Thr
        1075                1080                1085

 atc act gta ttg gac act caa gac aac cca cct gta ttc agt cag gtt     3370
 Ile Thr Val Leu Asp Thr Gln Asp Asn Pro Pro Val Phe Ser Gln Val
    1090                1095                1100

 gcc tac agc ttt gtg gtt ttt gag aac gtg gcg ctg gga tat cat gtg     3418
 Ala Tyr Ser Phe Val Val Phe Glu Asn Val Ala Leu Gly Tyr His Val
1105                1110                1115                1120

 ggt agt gtg tct gca tcc acc atg gat ctc aat tcc aac atc agt tat     3466
 Gly Ser Val Ser Ala Ser Thr Met Asp Leu Asn Ser Asn Ile Ser Tyr
                1125                1130                1135

 ctc att act act ggg gat cag aaa ggt atg ttt gct atc aac cag gtc     3514
 Leu Ile Thr Thr Gly Asp Gln Lys Gly Met Phe Ala Ile Asn Gln Val
            1140                1145                1150

 act ggg cag ctt acc aca gca aat gtg att gat aga gaa gag caa tcc     3562
 Thr Gly Gln Leu Thr Thr Ala Asn Val Ile Asp Arg Glu Glu Gln Ser
        1155                1160                1165

 ttt tat cag ctg aag gta gtg gcc agt ggg ggc aca gtg act gga gac     3610
 Phe Tyr Gln Leu Lys Val Val Ala Ser Gly Gly Thr Val Thr Gly Asp
    1170                1175                1180

 act atg gtt aac ata aca gtt aag gat ttg aat gac aac tct ccc cat     3658
 Thr Met Val Asn Ile Thr Val Lys Asp Leu Asn Asp Asn Ser Pro His
1185                1190                1195                1200

 ttc ctt cag gca ata gag agt gta aat gtg gtg gag aat tgg cag gca     3706
 Phe Leu Gln Ala Ile Glu Ser Val Asn Val Val Glu Asn Trp Gln Ala
                1205                1210                1215

 ggt cac agc att ttc cag gcc aaa gct gtg gac cct gat gaa ggt gtc     3754
 Gly His Ser Ile Phe Gln Ala Lys Ala Val Asp Pro Asp Glu Gly Val
            1220                1225                1230

 aat ggc atg gta ctc tat agt ctg aag caa aac ccc aag aac ctg ttt     3802
 Asn Gly Met Val Leu Tyr Ser Leu Lys Gln Asn Pro Lys Asn Leu Phe
        1235                1240                1245

 gct atc aat gaa aag aat ggc act att agt ctg ctt ggg ccc ctg gat     3850
 Ala Ile Asn Glu Lys Asn Gly Thr Ile Ser Leu Leu Gly Pro Leu Asp
    1250                1255                1260

 gtt cat gct ggc tcc tac caa ata gag atc ttg gca tct gac atg ggt     3898
 Val His Ala Gly Ser Tyr Gln Ile Glu Ile Leu Ala Ser Asp Met Gly
1265                1270                1275                1280

 gtc cca cag ctc tcc tct agt gtc atc tta aca gtt tat gtc cat gat     3946
 Val Pro Gln Leu Ser Ser Ser Val Ile Leu Thr Val Tyr Val His Asp
                1285                1290                1295

 gta aat gac aat tca cca gtg ttt gac caa ctc tct tat gaa gtc acc     3994
 Val Asn Asp Asn Ser Pro Val Phe Asp Gln Leu Ser Tyr Glu Val Thr
            1300                1305                1310

 ctt tct gag tca gaa cct gtg aat tct cga ttc ttt aaa gta caa gct     4042
 Leu Ser Glu Ser Glu Pro Val Asn Ser Arg Phe Phe Lys Val Gln Ala
        1315                1320                1325

 tct gat aag gat tca gga gca aat gat ggt caa ttg tat ata aaa agt     4090
 Ser Asp Lys Asp Ser Gly Ala Asn Asp Gly Gln Leu Tyr Ile Lys Ser
    1330                1335                1340

 gaa ctg gac cgt gaa ctt caa gac aga tat gtt tta atg gtt gtt gct     4138
 Glu Leu Asp Arg Glu Leu Gln Asp Arg Tyr Val Leu Met Val Val Ala
1345                1350                1355                1360

 tct gac aga gca gtg gaa ccc ctt agt gct act gtg aat gtt act gta     4186
 Ser Asp Arg Ala Val Glu Pro Leu Ser Ala Thr Val Asn Val Thr Val
                1365                1370                1375

 att tta gaa gat gta aat gat aac aga cct ctt ttt aac agt acc aat     4234
 Ile Leu Glu Asp Val Asn Asp Asn Arg Pro Leu Phe Asn Ser Thr Asn
            1380                1385                1390

 tac aca ttt tac ttc gaa gaa gag cag agg gct ggg tcg ttt gtg ggc     4282
 Tyr Thr Phe Tyr Phe Glu Glu Glu Gln Arg Ala Gly Ser Phe Val Gly
        1395                1400                1405

 gaa gta agt gct gta gat aaa gac ttt ggg cca aat gga gaa gta agg     4330
 Glu Val Ser Ala Val Asp Lys Asp Phe Gly Pro Asn Gly Glu Val Arg
    1410                1415                1420

 tat tct ttt gaa atg gtg cag cca gat ttt gag ttg cat gcc atc agt     4378
 Tyr Ser Phe Glu Met Val Gln Pro Asp Phe Glu Leu His Ala Ile Ser
1425                1430                1435                1440

 ggg gaa att aca aat act cat cag ttt gac agg gag tct ctt atg agg     4426
 Gly Glu Ile Thr Asn Thr His Gln Phe Asp Arg Glu Ser Leu Met Arg
                1445                1450                1455

 cgg aga ggg act gct gtg ttt agc ttt aca gtc ata gca aca gat cag     4474
 Arg Arg Gly Thr Ala Val Phe Ser Phe Thr Val Ile Ala Thr Asp Gln
            1460                1465                1470

 ggg atc cct cag cct ctc aag gat cag gcc act gta cat gtt tac atg     4522
 Gly Ile Pro Gln Pro Leu Lys Asp Gln Ala Thr Val His Val Tyr Met
        1475                1480                1485

 aag gat ata aat gat aat gct ccc aaa ttt tta aaa gac ttt tac caa     4570
 Lys Asp Ile Asn Asp Asn Ala Pro Lys Phe Leu Lys Asp Phe Tyr Gln
    1490                1495                1500

 gct aca ata tca gaa tca gca gcc aat ctg aca caa gtg tta aga gta     4618
 Ala Thr Ile Ser Glu Ser Ala Ala Asn Leu Thr Gln Val Leu Arg Val
1505                1510                1515                1520

 tct gcc tca gat gtt gat gaa ggt aat aat gga ctt att cac tat tct     4666
 Ser Ala Ser Asp Val Asp Glu Gly Asn Asn Gly Leu Ile His Tyr Ser
                1525                1530                1535

 ata ata aaa gga aat gaa gaa aga cag ttt gct ata gac agt acc tct     4714
 Ile Ile Lys Gly Asn Glu Glu Arg Gln Phe Ala Ile Asp Ser Thr Ser
            1540                1545                1550

 ggt cag gta aca cta att ggc aaa tta gac tat gaa gca aca cct gcc     4762
 Gly Gln Val Thr Leu Ile Gly Lys Leu Asp Tyr Glu Ala Thr Pro Ala
        1555                1560                1565

 tat tcc ctt gta att caa gca gtg gat tca ggg aca atc ccc ctc aat     4810
 Tyr Ser Leu Val Ile Gln Ala Val Asp Ser Gly Thr Ile Pro Leu Asn
    1570                1575                1580

 tca acg tgt act tta aat att gat att tta gat gaa aat gac aat acc     4858
 Ser Thr Cys Thr Leu Asn Ile Asp Ile Leu Asp Glu Asn Asp Asn Thr
1585                1590                1595                1600

 cct tct ttc cct aaa tca aca ctc ttt gtt gat gtt ttg gaa aac atg     4906
 Pro Ser Phe Pro Lys Ser Thr Leu Phe Val Asp Val Leu Glu Asn Met
                1605                1610                1615

 aga att ggt gaa ctc gtg tcc tct gtt act gca act gat tcc gat tca     4954
 Arg Ile Gly Glu Leu Val Ser Ser Val Thr Ala Thr Asp Ser Asp Ser
            1620                1625                1630

 ggt gac aat gct gat tta tat tac agt att act ggg act aac aac cac     5002
 Gly Asp Asn Ala Asp Leu Tyr Tyr Ser Ile Thr Gly Thr Asn Asn His
        1635                1640                1645

 gga act ttt agc att agc cca aac act ggg agt att ttt ctt gcc aaa     5050
 Gly Thr Phe Ser Ile Ser Pro Asn Thr Gly Ser Ile Phe Leu Ala Lys
    1650                1655                1660

 aaa ctg gac ttt gaa aca cag tct ttg tat aaa tta aat ata aca gca     5098
 Lys Leu Asp Phe Glu Thr Gln Ser Leu Tyr Lys Leu Asn Ile Thr Ala
1665                1670                1675                1680

 aaa gac caa gga aga cct cct cgt tca tct aca atg tca gtg gtt att     5146
 Lys Asp Gln Gly Arg Pro Pro Arg Ser Ser Thr Met Ser Val Val Ile
                1685                1690                1695

 cac gtg agg gac ttt aat gac aat cct cct agc ttt cct cct gga gat     5194
 His Val Arg Asp Phe Asn Asp Asn Pro Pro Ser Phe Pro Pro Gly Asp
            1700                1705                1710

 att ttc aag tct att gtt gag aac att ccc att ggt aca tct gtc att     5242
 Ile Phe Lys Ser Ile Val Glu Asn Ile Pro Ile Gly Thr Ser Val Ile
        1715                1720                1725

 tca gtg act gca cat gac cct gat gca gac att aat ggt caa cta tcc     5290
 Ser Val Thr Ala His Asp Pro Asp Ala Asp Ile Asn Gly Gln Leu Ser
    1730                1735                1740

 tac aca atc att caa cag atg cca aga ggc aac cac ttt acc ata gat     5338
 Tyr Thr Ile Ile Gln Gln Met Pro Arg Gly Asn His Phe Thr Ile Asp
1745                1750                1755                1760

 gaa gtc aaa ggg act ata tat act aat gct gaa ata gat cgg gaa ttt     5386
 Glu Val Lys Gly Thr Ile Tyr Thr Asn Ala Glu Ile Asp Arg Glu Phe
                1765                1770                1775

 gct aat ctc ttt gag ttg act gta aaa gcc aat gat caa gct gtg cca     5434
 Ala Asn Leu Phe Glu Leu Thr Val Lys Ala Asn Asp Gln Ala Val Pro
            1780                1785                1790

 ata gaa act aga cgg tat gct ttg aag aac gtg acc att ttg gtt aca     5482
 Ile Glu Thr Arg Arg Tyr Ala Leu Lys Asn Val Thr Ile Leu Val Thr
        1795                1800                1805

 gac ctc aat gac aat gtc cca atg ttt ata tca caa aac gcc ctt gct     5530
 Asp Leu Asn Asp Asn Val Pro Met Phe Ile Ser Gln Asn Ala Leu Ala
    1810                1815                1820

 gca gac cca tca gct gtg att ggt tcc gtt ctg aca aca att atg gct     5578
 Ala Asp Pro Ser Ala Val Ile Gly Ser Val Leu Thr Thr Ile Met Ala
1825                1830                1835                1840

 gct gac cca gat gaa ggt gct aat gga gaa ata gag tat gag atc atc     5626
 Ala Asp Pro Asp Glu Gly Ala Asn Gly Glu Ile Glu Tyr Glu Ile Ile
                1845                1850                1855

 aat ggg gac aca gac acc ttc att gtt gat cgt tat agt gga gac ctg     5674
 Asn Gly Asp Thr Asp Thr Phe Ile Val Asp Arg Tyr Ser Gly Asp Leu
            1860                1865                1870

 aga gtg gct tca gcg ttg gtg cct tca cag ttg atc tac aat ctc ata     5722
 Arg Val Ala Ser Ala Leu Val Pro Ser Gln Leu Ile Tyr Asn Leu Ile
        1875                1880                1885

 gtt tca gca aca gac ctt ggg cct gaa agg agg aaa tcg acc act gaa     5770
 Val Ser Ala Thr Asp Leu Gly Pro Glu Arg Arg Lys Ser Thr Thr Glu
    1890                1895                1900

 ttg acc atc att ctt cag ggc ctt gat gga cct gtt ttt act caa ccc     5818
 Leu Thr Ile Ile Leu Gln Gly Leu Asp Gly Pro Val Phe Thr Gln Pro
1905                1910                1915                1920

 aaa tat ata act att ttg aag gaa gga gaa ccc att ggc aca aac gtg     5866
 Lys Tyr Ile Thr Ile Leu Lys Glu Gly Glu Pro Ile Gly Thr Asn Val
                1925                1930                1935

 ata tca ata gaa gca gct agc ccc aga gga tct gag gcc cca gtg gag     5914
 Ile Ser Ile Glu Ala Ala Ser Pro Arg Gly Ser Glu Ala Pro Val Glu
            1940                1945                1950

 tat tat att gtt tca gtt cgt tgt gaa gaa aaa act gtt gga cgc ctc     5962
 Tyr Tyr Ile Val Ser Val Arg Cys Glu Glu Lys Thr Val Gly Arg Leu
        1955                1960                1965

 ttt act att gga cga cat act ggt ata att cag acc gca gcc att ctg     6010
 Phe Thr Ile Gly Arg His Thr Gly Ile Ile Gln Thr Ala Ala Ile Leu
    1970                1975                1980

 gac cgg gag caa gga gca tgt ctt tac ctg gtg gat gtt tat gcc ata     6058
 Asp Arg Glu Gln Gly Ala Cys Leu Tyr Leu Val Asp Val Tyr Ala Ile
1985                1990                1995                2000

 gaa aaa tca act gct ttt ccc aga aca cag aga gca gag gcc cct caa     6106
 Glu Lys Ser Thr Ala Phe Pro Arg Thr Gln Arg Ala Glu Ala Pro Gln
                2005                2010                2015

 aga cat tct agt gtc agt cag cca aaa aca caa aca tca aat gtg gtt     6154
 Arg His Ser Ser Val Ser Gln Pro Lys Thr Gln Thr Ser Asn Val Val
            2020                2025                2030

 tgt gat act tgg cag tga cccaga cacaacatgc aagtnaaatt naggctcatg     6208
 Cys Asp Thr Trp Gln 
        2035

 tgcttgtttt cttgcttctt tncttttttg gggggaggag gtggggattt tntttatttn   6268

 aaatgataat ttattattat nattatatat tttngtatcc tctgtgattt tttttcataa   6328

 tagttggtta tgtctatcta tggntgggga agatatttat ggcttaaagg gccatgatta   6388

 attagaggta taattctaag gggaatccaa ttttt                              6423




      <210> 243
      <211> 1034
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (310)..(846)

      <220>
      <221> misc_feature
      <222> (1)...(1034)
      <223> n = a,t,c or g

      <400> 243
 atgctctccc cggagagtga gcaaaagaag gcaagatgcc caacagtaat acaggttgtt     60

 ctcttaggga ggttttcgag gaaaagcgct tttctgcgct gcctaggaga cctgcgtacc    120

 ctcccgaagc cgaacagttg ctcggagcag tcggcttggc gccgcgagcg ccgggtgccc    180

 ctcttcggcc tcccgggttt ctcggaaaga aaactcaggt atctcttagc taaacaagcc    240

 tttgcagatt gtggagactt gaattatctg agaagagcta atctgggcct ctgcctgcac    300

 agctcttga    atg gtg tgg act gtc ccg agg aaa tcc aag gtt ccc gtg     348
              Met Val Trp Thr Val Pro Arg Lys Ser Lys Val Pro Val
                1               5                  10

 tca gtg gct atg atg aca cct caa gtt atc act ccc cag caa atg cag      396
 Ser Val Ala Met Met Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln
      15                  20                  25

 cag atc ctc cag caa caa gtg ctg agc cct cag cag ctc cag gtt ctc      444
 Gln Ile Leu Gln Gln Gln Val Leu Ser Pro Gln Gln Leu Gln Val Leu
  30                  35                  40                  45

 ctc cag cag cag cag gcc ctc atg ctt caa cag cag ctt caa gag ttt      492
 Leu Gln Gln Gln Gln Ala Leu Met Leu Gln Gln Gln Leu Gln Glu Phe
                  50                  55                  60

 tat aaa aaa caa cag gaa cag ttg cag ctt caa ctt tta caa caa caa      540
 Tyr Lys Lys Gln Gln Glu Gln Leu Gln Leu Gln Leu Leu Gln Gln Gln
              65                  70                  75

 cat gct gga aaa cag cct aaa gag caa cag cag gtg gct acc cag cag      588
 His Ala Gly Lys Gln Pro Lys Glu Gln Gln Gln Val Ala Thr Gln Gln
          80                  85                  90

 ttg gct ttt cag cag cag ctt tta cag atg cag cag tta cag cag cag      636
 Leu Ala Phe Gln Gln Gln Leu Leu Gln Met Gln Gln Leu Gln Gln Gln
      95                 100                 105

 cac ctc ctg tct ttg cag cgc caa ggc ctt ctg aca att cag ccc ggg      684
 His Leu Leu Ser Leu Gln Arg Gln Gly Leu Leu Thr Ile Gln Pro Gly
 110                 115                 120                 125

 cag cct gcc ctt ccc ctt caa cct ctt gct caa ggc atg att cca aca      732
 Gln Pro Ala Leu Pro Leu Gln Pro Leu Ala Gln Gly Met Ile Pro Thr
                 130                 135                 140

 gaa ctg cag cag ctc tgg aaa gaa gtg aca agt gct cat act gca gaa      780
 Glu Leu Gln Gln Leu Trp Lys Glu Val Thr Ser Ala His Thr Ala Glu
             145                 150                 155

 gaa acc aca ggc aac aat cac agc agt ttg gat ctg acc acg aca tgt      828
 Glu Thr Thr Gly Asn Asn His Ser Ser Leu Asp Leu Thr Thr Thr Cys
         160                 165                 170

 gtc tcc tcc tca aac tag aagctt ctccaagcat gatggccaca agncagtcct      882
 Val Ser Ser Ser Asn 
     175

 ctttctgtgc ctggcatatc tggtacttaa agaggactga cctgtgggtc gacgcggccg    942

 cgagcctgga atcgttaaca taaacagaac aaactcattc ttgagtctcg atagaatgat   1002

 tttacttctt ctaattaact gaatttagca gg                                 1034




      <210> 244
      <211> 1907
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (208)..(1695)

      <400> 244
 gcacgagaca aactccgagc atgctgcatc agtaccggcg gacacagcca gtgttctgaa     60

 agtctccctg ttcgcacact aagcattgca ccaggtcaat gtcgaccacc gagggttttg    120

 ggtagaccaa agcacaaaga agtccactta gagtgggatg ttcctgcatc ggaaagtggc    180

 tgtgaggtct cagagtacag cgtggag    atg acg gag ccc gaa gac gta gcc     231
                                  Met Thr Glu Pro Glu Asp Val Ala
                                    1               5

 tcg gaa gtg tac cat ggc cca gag ctg gag tgc acc gtc ggc aac ctg      279
 Ser Glu Val Tyr His Gly Pro Glu Leu Glu Cys Thr Val Gly Asn Leu
      10                  15                  20

 ctt cct gga acc gtg tat cgc ttc cgg gtg agg gct ctg aat gat gga      327
 Leu Pro Gly Thr Val Tyr Arg Phe Arg Val Arg Ala Leu Asn Asp Gly
  25                  30                  35                  40

 ggg tat ggt ccc tat tct gat gtc tca gaa att acc act gct gca ggg      375
 Gly Tyr Gly Pro Tyr Ser Asp Val Ser Glu Ile Thr Thr Ala Ala Gly
                  45                  50                  55

 cct cct gga caa tgc aaa gca cct tgt att tct tgt aca cct gat gga      423
 Pro Pro Gly Gln Cys Lys Ala Pro Cys Ile Ser Cys Thr Pro Asp Gly
              60                  65                  70

 tgt gtc tta gtg ggt tgg gag agt cct gat agt tct ggt gct gac atc      471
 Cys Val Leu Val Gly Trp Glu Ser Pro Asp Ser Ser Gly Ala Asp Ile
          75                  80                  85

 tca gag tac agg ttg gaa tgg gga gaa gat gaa gaa tcc tta gaa ctc      519
 Ser Glu Tyr Arg Leu Glu Trp Gly Glu Asp Glu Glu Ser Leu Glu Leu
      90                  95                 100

 att tat cat ggg aca gac acc cgt ttt gaa ata aga gac ctg ttg cct      567
 Ile Tyr His Gly Thr Asp Thr Arg Phe Glu Ile Arg Asp Leu Leu Pro
 105                 110                 115                 120

 gct gca cag tat tgc tgt aga cta cag gcc ttc aat caa gca ggg gca      615
 Ala Ala Gln Tyr Cys Cys Arg Leu Gln Ala Phe Asn Gln Ala Gly Ala
                 125                 130                 135

 ggg ccg tac agt gaa ctt gtc ctt tgc cag acg cca gcg tct gcc cct      663
 Gly Pro Tyr Ser Glu Leu Val Leu Cys Gln Thr Pro Ala Ser Ala Pro
             140                 145                 150

 gac ccc gtc tcc act ctc tgt gtc ctg gag gag gag ccc ctt gat gcc      711
 Asp Pro Val Ser Thr Leu Cys Val Leu Glu Glu Glu Pro Leu Asp Ala
         155                 160                 165

 tac cct gat tca cct tct gcg tgc ctt gta ctg aac tgg gaa gag ccg      759
 Tyr Pro Asp Ser Pro Ser Ala Cys Leu Val Leu Asn Trp Glu Glu Pro
     170                 175                 180

 tgc aat aac gga tct gaa atc ctt gct tac acc att gat cta gga gac      807
 Cys Asn Asn Gly Ser Glu Ile Leu Ala Tyr Thr Ile Asp Leu Gly Asp
 185                 190                 195                 200

 act agc att acc gtg ggc aac acc acc atg cat gtt atg aaa gat ctc      855
 Thr Ser Ile Thr Val Gly Asn Thr Thr Met His Val Met Lys Asp Leu
                 205                 210                 215

 ctt cca gaa acc acc tac cgg atc aga att cag gct ata aat gaa att      903
 Leu Pro Glu Thr Thr Tyr Arg Ile Arg Ile Gln Ala Ile Asn Glu Ile
             220                 225                 230

 gga gct gga cca ttt agt cag ttc att aaa gca aaa act cgg cca tta      951
 Gly Ala Gly Pro Phe Ser Gln Phe Ile Lys Ala Lys Thr Arg Pro Leu
         235                 240                 245

 cca ccc ttg cct cct agg cta gaa tgt gct gct gct ggt cct cag agc      999
 Pro Pro Leu Pro Pro Arg Leu Glu Cys Ala Ala Ala Gly Pro Gln Ser
     250                 255                 260

 ctg aag cta aaa tgg gga gac agt aac tcc aag aca cat gct gct gag     1047
 Leu Lys Leu Lys Trp Gly Asp Ser Asn Ser Lys Thr His Ala Ala Glu
 265                 270                 275                 280

 gac att gtg tac aca cta cag ctg gag gac aga aac aag agg ttt att     1095
 Asp Ile Val Tyr Thr Leu Gln Leu Glu Asp Arg Asn Lys Arg Phe Ile
                 285                 290                 295

 tca atc tac aga gga ccc agc cac acc tac aag gtc cag aga ctg acg     1143
 Ser Ile Tyr Arg Gly Pro Ser His Thr Tyr Lys Val Gln Arg Leu Thr
             300                 305                 310

 gaa ttc aca tgc tac tcc ttc aga atc cag gca gca agc gag gct gga     1191
 Glu Phe Thr Cys Tyr Ser Phe Arg Ile Gln Ala Ala Ser Glu Ala Gly
         315                 320                 325

 gaa ggg ccc ttc tca gaa acc tat acc ttc agc aca acc aaa agt gtc     1239
 Glu Gly Pro Phe Ser Glu Thr Tyr Thr Phe Ser Thr Thr Lys Ser Val
     330                 335                 340

 ccc ccc acc atc aaa gca cct cga gta aca cag tta gaa gga aat tca     1287
 Pro Pro Thr Ile Lys Ala Pro Arg Val Thr Gln Leu Glu Gly Asn Ser
 345                 350                 355                 360

 tgt gaa att tta tgg gag acg gta cca tca atg aaa ggt gac cct gtt     1335
 Cys Glu Ile Leu Trp Glu Thr Val Pro Ser Met Lys Gly Asp Pro Val
                 365                 370                 375

 aac tac att ctg cag gta ttg gtt gga aga gaa tct gag tac aaa cag     1383
 Asn Tyr Ile Leu Gln Val Leu Val Gly Arg Glu Ser Glu Tyr Lys Gln
             380                 385                 390

 gtg tac aag gga gaa gaa gcc aca ttc caa atc tca ggc ctc cag acc     1431
 Val Tyr Lys Gly Glu Glu Ala Thr Phe Gln Ile Ser Gly Leu Gln Thr
         395                 400                 405

 aac aca gac tac agg ttc cgc gta tgt gcg tgt cgt cgc tgt tta gac     1479
 Asn Thr Asp Tyr Arg Phe Arg Val Cys Ala Cys Arg Arg Cys Leu Asp
     410                 415                 420

 acc tct cag gag cta agc gga gcc ttc agc ccc tct gcg gct ttt gta     1527
 Thr Ser Gln Glu Leu Ser Gly Ala Phe Ser Pro Ser Ala Ala Phe Val
 425                 430                 435                 440

 tta caa cga agt gag gtc atg ctt aca ggg gac atg ggg agc tta gat     1575
 Leu Gln Arg Ser Glu Val Met Leu Thr Gly Asp Met Gly Ser Leu Asp
                 445                 450                 455

 gat ccc aaa atg aag agc atg atg cct act gat gaa cag ttt gca gcc     1623
 Asp Pro Lys Met Lys Ser Met Met Pro Thr Asp Glu Gln Phe Ala Ala
             460                 465                 470

 atc att gtg ctt ggc ttt gca act ttg tcc att tta ttt gcc ttt ata     1671
 Ile Ile Val Leu Gly Phe Ala Thr Leu Ser Ile Leu Phe Ala Phe Ile
         475                 480                 485

 tta cag tac ttc tta atg aag taa acccaacaaa actagaggta tgaattaatg    1725
 Leu Gln Tyr Phe Leu Met Lys 
     490                 495

 ctacacattt taatacacac atttattcag atactcccct ttttaaagcc cttttgtttt   1785

 ttgatttata tactctgttt tacagattta gctagaaaaa aaatgtcagt gttttggtgc   1845

 acctttttga aatgcaaaac taggaaaagg ttaaactgga tttttttttt aaaaaaaaaa   1905

 aa                                                                  1907




      <210> 245
      <211> 1889
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(1111)

      <400> 245
 ctggtcggcg gacgtgctgc cgagtagtcc cggaagcgaa gcagcg   atg gcg gag      55
                                                      Met Ala Glu
                                                        1

 agt ccg act gag gag gcg gca acg gcg ggc gcc ggg gcg gcg ggc ccc      103
 Ser Pro Thr Glu Glu Ala Ala Thr Ala Gly Ala Gly Ala Ala Gly Pro
       5                  10                  15

 ggg gcg agc agc gtt gct ggt gtt gtt ggc gtt agc ggc agc ggc ggc      151
 Gly Ala Ser Ser Val Ala Gly Val Val Gly Val Ser Gly Ser Gly Gly
  20                  25                  30                  35

 ggg ttc ggg ccg cct ttc ctg ccg gat gtg tgg gcg gcg gcg gcg gca      199
 Gly Phe Gly Pro Pro Phe Leu Pro Asp Val Trp Ala Ala Ala Ala Ala
                  40                  45                  50

 gcg ggc ggg gcc ggg ggc ccg ggg agc ggc ctg gct ccg ctg ccc ggg      247
 Ala Gly Gly Ala Gly Gly Pro Gly Ser Gly Leu Ala Pro Leu Pro Gly
              55                  60                  65

 ctc ccg ccc tca gcc gct gcc cac ggg gcc gcg ctg ctt agc cac tgg      295
 Leu Pro Pro Ser Ala Ala Ala His Gly Ala Ala Leu Leu Ser His Trp
          70                  75                  80

 gac ccc acg ctc agc tcc gac tgg gac ggc gag cgc acc gcg ccg cag      343
 Asp Pro Thr Leu Ser Ser Asp Trp Asp Gly Glu Arg Thr Ala Pro Gln
      85                  90                  95

 tgt cta ctc cgg atc aag cgg gat atc atg tcc att tat aag gag cct      391
 Cys Leu Leu Arg Ile Lys Arg Asp Ile Met Ser Ile Tyr Lys Glu Pro
 100                 105                 110                 115

 cct cca gga atg ttc gtt gta cct gat act gtt gac atg act aag att      439
 Pro Pro Gly Met Phe Val Val Pro Asp Thr Val Asp Met Thr Lys Ile
                 120                 125                 130

 cat gca ttg atc aca ggc cca ttt gac act cct tat gaa ggg ggt ttc      487
 His Ala Leu Ile Thr Gly Pro Phe Asp Thr Pro Tyr Glu Gly Gly Phe
             135                 140                 145

 ttc ctg ttc gtg ttt cgg tgt ccg ccc gac tat ccc atc cac cca cct      535
 Phe Leu Phe Val Phe Arg Cys Pro Pro Asp Tyr Pro Ile His Pro Pro
         150                 155                 160

 cgg gtc aaa ctg atg aca acg ggc aat aac aca gtg agg ttt aac ccc      583
 Arg Val Lys Leu Met Thr Thr Gly Asn Asn Thr Val Arg Phe Asn Pro
     165                 170                 175

 aac ttc tac cgc aat ggg aaa gtc tgc ttg agt att cta ggt aca tgg      631
 Asn Phe Tyr Arg Asn Gly Lys Val Cys Leu Ser Ile Leu Gly Thr Trp
 180                 185                 190                 195

 act gga cct gcc tgg agc cca gcc cag agc atc tcc tca gtg ctc atc      679
 Thr Gly Pro Ala Trp Ser Pro Ala Gln Ser Ile Ser Ser Val Leu Ile
                 200                 205                 210

 tct atc cag tcc ctg atg act gag aac ccc tat cac aat gag ccc ggc      727
 Ser Ile Gln Ser Leu Met Thr Glu Asn Pro Tyr His Asn Glu Pro Gly
             215                 220                 225

 ttt gaa cag gag aga cat cca gga gac agc aaa aac tat aat gaa tgt      775
 Phe Glu Gln Glu Arg His Pro Gly Asp Ser Lys Asn Tyr Asn Glu Cys
         230                 235                 240

 atc cgg cac gag acc atc aga gtt gca gtc tgt gac atg atg gaa gga      823
 Ile Arg His Glu Thr Ile Arg Val Ala Val Cys Asp Met Met Glu Gly
     245                 250                 255

 aag tgt ccc tgt cct gaa ccc cta cga ggg gtg atg gag aag tcc ttt      871
 Lys Cys Pro Cys Pro Glu Pro Leu Arg Gly Val Met Glu Lys Ser Phe
 260                 265                 270                 275

 ctg gag tat tac gac ttc tat gag gtg gcc tgc aaa gat cgc ctg cac      919
 Leu Glu Tyr Tyr Asp Phe Tyr Glu Val Ala Cys Lys Asp Arg Leu His
                 280                 285                 290

 ctt caa ggc caa act atg cag gac cct ttt gga gag aag cgg ggc cac      967
 Leu Gln Gly Gln Thr Met Gln Asp Pro Phe Gly Glu Lys Arg Gly His
             295                 300                 305

 ttt gac tac cag tcc ctc ttg atg cgc ctg gga ctg ata cgt cag aaa     1015
 Phe Asp Tyr Gln Ser Leu Leu Met Arg Leu Gly Leu Ile Arg Gln Lys
         310                 315                 320

 gtg ctg gag agg ctc cat aat gag aat gca gaa atg gac tct gat agc     1063
 Val Leu Glu Arg Leu His Asn Glu Asn Ala Glu Met Asp Ser Asp Ser
     325                 330                 335

 agt tca tct ggg aca gag aca gac ctt cat ggg agc ctg agg gtt tag     1111
 Ser Ser Ser Gly Thr Glu Thr Asp Leu His Gly Ser Leu Arg Val 
 340                 345                 350

 accctgctcc catctcccct tcccccactc aagagtccca gcagaatccc ttccccccac   1171

 cccagggatg gagaggcact gtgtatctcc ctccagactc gaagtcatcc tgcaaggatg   1231

 gcaagaacca agcaagctcc gatcccaggg tgtgggagtg gggggcctgt tcccggtctg   1291

 acctccttgg cactggagcc atctggcggc ttcgttcatc cattcatccc gtatcagggg   1351

 ccaaggtacc tttacaggag cacctagagc gagggccttg tggccacacc acaacaacaa   1411

 cacaacacac ctctccacag ggccagctcc ttcaggataa cgtggcacga tggcaattgc   1471

 aatcccagag ggagtgtgcg caactgatcc accgcgaact cctggcagca cttccggtgg   1531

 gcgctcgcca ggggaacact atgcagctcg caggcgagca cacatgccag agtaacgcct   1591

 caggaagcag ggctccatcg gcacctcgca tcctggctta cttccacaat accctcctca   1651

 aggccacaca cagtcggtcg actactagca tccacgcgcc taaaacacac gagagaacgt   1711

 gcggatacgg gtgcgataca acgaaacata gacgccaaat atagccaccg agcgaaccga   1771

 cagtatagag cgacgtacga taaaagattg aggcagcagc tcaacaggcg ccgcagtaca   1831

 ccacgacgta tgtacgaacg tcagaaacaa tggagactca gcacaaccac aacacctt     1889




      <210> 246
      <211> 1847
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(1759)

      <400> 246
 cgcc atg gcg gcg gca gcg gtg tca gag tct tgg ccg gag ctg gag ctg      49
      Met Ala Ala Ala Ala Val Ser Glu Ser Trp Pro Glu Leu Glu Leu
        1               5                  10                  15

 gct gag cgc gag cgg cgg cgg gag ctg ctg ctg acg ggg ccc ggg ctg       97
 Ala Glu Arg Glu Arg Arg Arg Glu Leu Leu Leu Thr Gly Pro Gly Leu
                  20                  25                  30

 gag gag cga gtg cgg gcg gcg ggt ggg cag ctg ccg ccg cgg ctt ttc      145
 Glu Glu Arg Val Arg Ala Ala Gly Gly Gln Leu Pro Pro Arg Leu Phe
              35                  40                  45

 acc ctg ccg ctg ctg cac tac ttg gaa gtg agc ggc tgc ggg agc ttg      193
 Thr Leu Pro Leu Leu His Tyr Leu Glu Val Ser Gly Cys Gly Ser Leu
          50                  55                  60

 cgc gcg ccg ggg cct ggc ctg gcg cag ggc ctg ccg cag ctg cac agc      241
 Arg Ala Pro Gly Pro Gly Leu Ala Gln Gly Leu Pro Gln Leu His Ser
      65                  70                  75

 ctc gtg ctg cgg cgc aac gcg ctg ggg ccc ggc ctg agc ccc gag ctc      289
 Leu Val Leu Arg Arg Asn Ala Leu Gly Pro Gly Leu Ser Pro Glu Leu
  80                  85                  90                  95

 ggg ccg ctg cct gcc ctt cgg gtg ctc gac ctg tcg ggc aac gcg cct      337
 Gly Pro Leu Pro Ala Leu Arg Val Leu Asp Leu Ser Gly Asn Ala Pro
                 100                 105                 110

 gga ggc gct gcc gcc ggg cca agg cct ggg ccc cgc cga gcc gcc ggg      385
 Gly Gly Ala Ala Ala Gly Pro Arg Pro Gly Pro Arg Arg Ala Ala Gly
             115                 120                 125

 cct tcc gca gct gca gag cct caa cct cag cgg caa ccg gct gcg cgg      433
 Pro Ser Ala Ala Ala Glu Pro Gln Pro Gln Arg Gln Pro Ala Ala Arg
         130                 135                 140

 agc tgg cca gcc gac ctg gcg cgc tgc gcc ccg cgc ctg cag agc ctc      481
 Ser Trp Pro Ala Asp Leu Ala Arg Cys Ala Pro Arg Leu Gln Ser Leu
     145                 150                 155

 aac ctc acc ggc aat tgc cta gac tcc ttt ccc gcc gag ctc ttt cgc      529
 Asn Leu Thr Gly Asn Cys Leu Asp Ser Phe Pro Ala Glu Leu Phe Arg
 160                 165                 170                 175

 ccc ggc gcg ctg ccc ctg ctc agt gaa ctg gcg gct gct gac aac tgc      577
 Pro Gly Ala Leu Pro Leu Leu Ser Glu Leu Ala Ala Ala Asp Asn Cys
                 180                 185                 190

 ctc cga gaa ctc agc ccc gac atc gcc cac ctg gcc tcg ctc aag acg      625
 Leu Arg Glu Leu Ser Pro Asp Ile Ala His Leu Ala Ser Leu Lys Thr
             195                 200                 205

 ttg gac ctc tcg aac aac cag ctg agc gag atc cct gca gag ctt gcg      673
 Leu Asp Leu Ser Asn Asn Gln Leu Ser Glu Ile Pro Ala Glu Leu Ala
         210                 215                 220

 gac tgc ccc aag ctc aag gag atc aat ttc cgt ggg aac aag ctg agg      721
 Asp Cys Pro Lys Leu Lys Glu Ile Asn Phe Arg Gly Asn Lys Leu Arg
     225                 230                 235

 gac aag cgc ctg gag aag atg gtc agc ggc tgc cag acc aga tcc atc      769
 Asp Lys Arg Leu Glu Lys Met Val Ser Gly Cys Gln Thr Arg Ser Ile
 240                 245                 250                 255

 ctg gag tac ctg cgc gtc gga ggc cgt ggt ggc ggg aag ggc aag ggc      817
 Leu Glu Tyr Leu Arg Val Gly Gly Arg Gly Gly Gly Lys Gly Lys Gly
                 260                 265                 270

 cgt gcc gag ggc tcg gag aag gaa gag agc cgg agg aag agg agg gag      865
 Arg Ala Glu Gly Ser Glu Lys Glu Glu Ser Arg Arg Lys Arg Arg Glu
             275                 280                 285

 agg aag cag agg cgg gaa ggt ggt gat ggg gag gag cag gac gtg gga      913
 Arg Lys Gln Arg Arg Glu Gly Gly Asp Gly Glu Glu Gln Asp Val Gly
         290                 295                 300

 gat gcc ggc cgg ctg ctg ctc agg gtc ctg cac gtc tct gaa aac ccc      961
 Asp Ala Gly Arg Leu Leu Leu Arg Val Leu His Val Ser Glu Asn Pro
     305                 310                 315

 gta cct ctg aca gtc aga gtg agc ccc gag gtc cgg gat gtg cgg ccc     1009
 Val Pro Leu Thr Val Arg Val Ser Pro Glu Val Arg Asp Val Arg Pro
 320                 325                 330                 335

 tac att gtg ggg gcc gtg gtg cga ggc atg gac ctg cag cca ggg aat     1057
 Tyr Ile Val Gly Ala Val Val Arg Gly Met Asp Leu Gln Pro Gly Asn
                 340                 345                 350

 gca ctc aag cgc ttc ctc acc tcg cag acc aag ctc cac gaa gat ctc     1105
 Ala Leu Lys Arg Phe Leu Thr Ser Gln Thr Lys Leu His Glu Asp Leu
             355                 360                 365

 tgt gag aag agg acg gct gcc acc ctt gcc acc cac gag ctc cgt gcc     1153
 Cys Glu Lys Arg Thr Ala Ala Thr Leu Ala Thr His Glu Leu Arg Ala
         370                 375                 380

 gtc aaa ggg ccc ctg ctg tac tgc gcc cgg ccc cca cag gac ctc aag     1201
 Val Lys Gly Pro Leu Leu Tyr Cys Ala Arg Pro Pro Gln Asp Leu Lys
     385                 390                 395

 att gtc ccc ttg ggg cgg aaa gaa gcc aag gcc aag gag ctg gtg cgg     1249
 Ile Val Pro Leu Gly Arg Lys Glu Ala Lys Ala Lys Glu Leu Val Arg
 400                 405                 410                 415

 cag ctg cag ctg gag gcc gag gag cag agg aag cag aag aag cgg cag     1297
 Gln Leu Gln Leu Glu Ala Glu Glu Gln Arg Lys Gln Lys Lys Arg Gln
                 420                 425                 430

 agt gtg tcg ggc ctg cac aga tac ctt cac ttg ctg gat gga aat gaa     1345
 Ser Val Ser Gly Leu His Arg Tyr Leu His Leu Leu Asp Gly Asn Glu
             435                 440                 445

 aat tac ccg tgt ctt gtg gat gca gac ggt gat gtg att tcc ttc cca     1393
 Asn Tyr Pro Cys Leu Val Asp Ala Asp Gly Asp Val Ile Ser Phe Pro
         450                 455                 460

 cca ata acc aac agt gag aag aca aag gtt aag aaa acg act tct gat     1441
 Pro Ile Thr Asn Ser Glu Lys Thr Lys Val Lys Lys Thr Thr Ser Asp
     465                 470                 475

 ttg ttt ttg gaa gta aca agt gcc acc agt ctg cag att tgc aag gat     1489
 Leu Phe Leu Glu Val Thr Ser Ala Thr Ser Leu Gln Ile Cys Lys Asp
 480                 485                 490                 495

 gtc atg gat gcc ctc att ctg aaa atg gca gaa atg aaa aag tac act     1537
 Val Met Asp Ala Leu Ile Leu Lys Met Ala Glu Met Lys Lys Tyr Thr
                 500                 505                 510

 tta gaa aat aaa gag gaa gga tca ctc tca gat act gaa gcc gat gca     1585
 Leu Glu Asn Lys Glu Glu Gly Ser Leu Ser Asp Thr Glu Ala Asp Ala
             515                 520                 525

 gtc tct gga caa ctt cca gat ccc aca acg aat ccc agt gct gga aag     1633
 Val Ser Gly Gln Leu Pro Asp Pro Thr Thr Asn Pro Ser Ala Gly Lys
         530                 535                 540

 gac ggg ccc tcc ctt ctg gtg gtg gag cag gtc cgg gtg gtg gat ctg     1681
 Asp Gly Pro Ser Leu Leu Val Val Glu Gln Val Arg Val Val Asp Leu
     545                 550                 555

 gaa ggg agc ctg aag gtg gtg tac ccg tcc aag gcc gac ctg gcc act     1729
 Glu Gly Ser Leu Lys Val Val Tyr Pro Ser Lys Ala Asp Leu Ala Thr
 560                 565                 570                 575

 gcc cct ccc cac gtg act gtc gtg cgc tga c gccagggccg cctgtccgcg     1780
 Ala Pro Pro His Val Thr Val Val Arg 
                 580

 tttgtttggc cggtttgcgg aggtttctat gcggcaatgc tgaattatcc gttagatttt   1840

 cacccca                                                             1847




      <210> 247
      <211> 1287
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(1044)

      <400> 247
 aatagcttat tggaaacttt tacgggtcat gtgacttgtc acactgactc cttgaggtgg     60

 gtttaccaat ctcctataga tggggaaacc gaggcacaag agctaagtta ctcatctaag    120

 ggaaagaacc atgatccagt cccaggcctg tgtgactac   atg gtc ttt tac aaa     174
                                              Met Val Phe Tyr Lys
                                                1               5

 ata ttt gcc cat cag aga caa aat act ggt cta gct aga act cag gtt      222
 Ile Phe Ala His Gln Arg Gln Asn Thr Gly Leu Ala Arg Thr Gln Val
                  10                  15                  20

 gat gca gca gga caa ctg gga aat tac tgt gta ctg cag ctt gaa gaa      270
 Asp Ala Ala Gly Gln Leu Gly Asn Tyr Cys Val Leu Gln Leu Glu Glu
              25                  30                  35

 aaa ggg cat ctc tgg ctg aaa tca atc acc ctc agc ctg gga gct cag      318
 Lys Gly His Leu Trp Leu Lys Ser Ile Thr Leu Ser Leu Gly Ala Gln
          40                  45                  50

 cct tct gct gga aga atc tgc ctt gga gga gaa agc cat agg gct gac      366
 Pro Ser Ala Gly Arg Ile Cys Leu Gly Gly Glu Ser His Arg Ala Asp
      55                  60                  65

 agc ggt gct ctg cca ttt cct ccc cca cgc agt ggg tgc tgc tgg cct      414
 Ser Gly Ala Leu Pro Phe Pro Pro Pro Arg Ser Gly Cys Cys Trp Pro
  70                  75                  80                  85

 gtg gag acc tgt gct gcc agc cac gcc cca tgc ctc ctg att gtg ctt      462
 Val Glu Thr Cys Ala Ala Ser His Ala Pro Cys Leu Leu Ile Val Leu
                  90                  95                 100

 tgc ctc tcg ctg cca tac aag tca ggg ctg gca cct cat ttt ccg ctg      510
 Cys Leu Ser Leu Pro Tyr Lys Ser Gly Leu Ala Pro His Phe Pro Leu
             105                 110                 115

 cag aga caa ggc att gcc tcc tgg agg cca gag gga gga cag gag gaa      558
 Gln Arg Gln Gly Ile Ala Ser Trp Arg Pro Glu Gly Gly Gln Glu Glu
         120                 125                 130

 atc cag gga agc aga ccc ttt cag tgt ctg cct gct cct tgc cat cca      606
 Ile Gln Gly Ser Arg Pro Phe Gln Cys Leu Pro Ala Pro Cys His Pro
     135                 140                 145

 cca caa acc ctc acc gaa cca gtg gcc acc acc atg aca agg gac cag      654
 Pro Gln Thr Leu Thr Glu Pro Val Ala Thr Thr Met Thr Arg Asp Gln
 150                 155                 160                 165

 aat gga acc tgg gag atg gag agt aat gaa aac ttt gag ggc tac atg      702
 Asn Gly Thr Trp Glu Met Glu Ser Asn Glu Asn Phe Glu Gly Tyr Met
                 170                 175                 180

 aag gcc ctg gat att gat ttt gcc acc cgc aag att gca gta cgt ctc      750
 Lys Ala Leu Asp Ile Asp Phe Ala Thr Arg Lys Ile Ala Val Arg Leu
             185                 190                 195

 act cag acg aag gtt att gat caa gat ggt gat aac ttc aag aca aaa      798
 Thr Gln Thr Lys Val Ile Asp Gln Asp Gly Asp Asn Phe Lys Thr Lys
         200                 205                 210

 acc act agc aca ttc cgc aac tat gat gtg gat ttc act gtt gga gta      846
 Thr Thr Ser Thr Phe Arg Asn Tyr Asp Val Asp Phe Thr Val Gly Val
     215                 220                 225

 gag ttt gac gag tac aca aag agc ctg gat aac cgg cat gtt aag gca      894
 Glu Phe Asp Glu Tyr Thr Lys Ser Leu Asp Asn Arg His Val Lys Ala
 230                 235                 240                 245

 ctg gtc acc tgg gaa ggt gat gtc ctt gtg tgt gtg caa aag ggg gag      942
 Leu Val Thr Trp Glu Gly Asp Val Leu Val Cys Val Gln Lys Gly Glu
                 250                 255                 260

 aag gag aac cgc ggc tgg aag cag tgg att gag ggg gac aag ctg tac      990
 Lys Glu Asn Arg Gly Trp Lys Gln Trp Ile Glu Gly Asp Lys Leu Tyr
             265                 270                 275

 ctg gag ctg acc tgt ggt gac cag gtg tgc cgt caa gtg ttc aaa aag     1038
 Leu Glu Leu Thr Cys Gly Asp Gln Val Cys Arg Gln Val Phe Lys Lys
         280                 285                 290

 aaa tga tggcgacgtg ggaggcctgc caagcacaag ctccccactg cccacactga      1094
 Lys 


 gtggtctact ggctttgaga aacagctgtg gggaccttcc cactcttgac agagccccat   1154

 taaggcatct gggtgggttt taaacagaat gcctatgtag cagtgataga catattcccc   1214

 tcctttgaaa cctagcatta aatggaaaaa caaaaattac tcccatattt tgaaaccctt   1274

 taaaaaaaaa aaa                                                      1287




      <210> 248
      <211> 500
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (42)..(416)

      <400> 248
 aacagaagac ttggcatcga gggtcaggac cacagcctga c    atg gca ggg aga      53
                                                  Met Ala Gly Arg
                                                    1

 gat aat gat cag cag att ggt cta aat gtc tcc aaa gtc tcg tcc aag      101
 Asp Asn Asp Gln Gln Ile Gly Leu Asn Val Ser Lys Val Ser Ser Lys
   5                  10                  15                  20

 tct gct acc ttg aca ttc tat gaa tcg gaa ggc tgg aat act ggc cag      149
 Ser Ala Thr Leu Thr Phe Tyr Glu Ser Glu Gly Trp Asn Thr Gly Gln
                  25                  30                  35

 tgg gct gtg cta aag ttt gct gtt tcc act ggg gcc act ctt att gct      197
 Trp Ala Val Leu Lys Phe Ala Val Ser Thr Gly Ala Thr Leu Ile Ala
              40                  45                  50

 ggg cac ttc act cct gga act ttc act aat cag atc cag gca gcc ttc      245
 Gly His Phe Thr Pro Gly Thr Phe Thr Asn Gln Ile Gln Ala Ala Phe
          55                  60                  65

 cag gag cca cgg ctt ctt gtg gtt act gac ccc agg ctg acc acc agc      293
 Gln Glu Pro Arg Leu Leu Val Val Thr Asp Pro Arg Leu Thr Thr Ser
      70                  75                  80

 ctc tca cgg agg cat ctt atg tta acc tac cta cca tgc gct gtg caa      341
 Leu Ser Arg Arg His Leu Met Leu Thr Tyr Leu Pro Cys Ala Val Gln
  85                  90                  95                 100

 cac aga tct ctt atc tgc gct atg tgg aca ttg cca tcc cat gca tca      389
 His Arg Ser Leu Ile Cys Ala Met Trp Thr Leu Pro Ser His Ala Ser
                 105                 110                 115

 aca cgg gag ctc act cag tgg gtt tga tgtgg tggatgctgg ctcgggaagt      441
 Thr Arg Glu Leu Thr Gln Trp Val 
             120

 tctgcgcatg cgtggcacca tttcccgtga acacccatgg gagtcatgct gatggtacc     500




      <210> 249
      <211> 2709
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (746)..(1663)

      <400> 249
 tgctctggtc cccaggagag gaagtgtctc tgatgaggga cctgcctgtg ggaagatcat     60

 ggagctgtct ttgatcttcg gagaagtctg tcccaccact gcagtgacca cagttgtgtt    120

 gggctcacac cagtgaaccg aagctctgga ttctgagagt ctgaggattc cgtgaagatc    180

 tcagacttgg gctcagagca aggatgcgtg aaattgtcca tattcagatt ggccagtgtg    240

 gcaaccagat cggagccaag ttctgggaga tgattggtga ggaacacggg atcgacttgg    300

 ctgggagcga ccgcggggcc tcggccttgc agctggagag aatcagcgtg tactacaacg    360

 aagcctacgg taggaaatat gtgccccgag cagtcttggt ggacctagaa cctgggacga    420

 tggacagcat tcgatctagc aaattaggag ctctctttca acccgacagt tttgtccatg    480

 gtatgttttt ccagaaggtt ccaccaggag gaggggggga tgctttactg gtgcccttct    540

 cttttcacct ttcttcccct gctggtttct ctttttggcc acaggtaact ctggggctgg    600

 caacaactgg gccaaaggcc actacacgga gggagccgag ctgatcgaga atgtcctaga    660

 ggtggtgagg cacgagagtg agagctgtga ctgcctgcag ggcttccaga tcgtccactc    720

 cctgggcggg ggcacaggct ccggg  atg ggc act ctg ctc atg aac aag att     772
                              Met Gly Thr Leu Leu Met Asn Lys Ile
                                1               5

 aga gag gag tac ccg gac cgg atc atg aat tcc ttc agc gtc atg cct      820
 Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Ser Phe Ser Val Met Pro
  10                  15                  20                  25

 tct ccc aag gtg tcg gac acg gtg gtg gag ccc tac aac gcg gtt ctg      868
 Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn Ala Val Leu
                  30                  35                  40

 tct atc cac cag ctg att gag aat gca gat gcc tgt ttc tgc att gac      916
 Ser Ile His Gln Leu Ile Glu Asn Ala Asp Ala Cys Phe Cys Ile Asp
              45                  50                  55

 aat gag gcc ctc tat gac atc tgc ttc cgt acc ctg aag ctg acg aca      964
 Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr Thr
          60                  65                  70

 ccc acc tat ggg gat ctc aac cac cta gtg tcc ttg acc atg agc ggc     1012
 Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Leu Thr Met Ser Gly
      75                  80                  85

 ata acc acc tcc ctc cgg ttc ccg ggt cag ctc aac gca gac ctg cgc     1060
 Ile Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu Arg
  90                  95                 100                 105

 aag ctg gcg gtg aac atg gtc ccc ttc ccc cgc ctg cac ttc ttt atg     1108
 Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe Met
                 110                 115                 120

 ccc ggc ttt gcc cca ctc acg gcc cag ggc agc cag cag tac cga gcc     1156
 Pro Gly Phe Ala Pro Leu Thr Ala Gln Gly Ser Gln Gln Tyr Arg Ala
             125                 130                 135

 ctc tcc gtg gcc gag ctc acc cag cag atg ttc gat gcc cgc aat acc     1204
 Leu Ser Val Ala Glu Leu Thr Gln Gln Met Phe Asp Ala Arg Asn Thr
         140                 145                 150

 atg gct gcc tgt gac ctc cgc cgt ggc cgc tac ctc aca gtg gcc tgc     1252
 Met Ala Ala Cys Asp Leu Arg Arg Gly Arg Tyr Leu Thr Val Ala Cys
     155                 160                 165

 att ttc cgg ggc aag atg tcc acc aag gaa gtg gac cag caa ctg ctc     1300
 Ile Phe Arg Gly Lys Met Ser Thr Lys Glu Val Asp Gln Gln Leu Leu
 170                 175                 180                 185

 tcc gtg cag acc agg aac agc agc tgc ttt gtg gag tgg att ccc aac     1348
 Ser Val Gln Thr Arg Asn Ser Ser Cys Phe Val Glu Trp Ile Pro Asn
                 190                 195                 200

 aac gtc aag gtg gct gtc tgc gac atc ccg ccc cgg ggg ctg agc atg     1396
 Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly Leu Ser Met
             205                 210                 215

 gcc gcc acc ttc att ggc aac aac acg gcc atc caa gag atc ttt aat     1444
 Ala Ala Thr Phe Ile Gly Asn Asn Thr Ala Ile Gln Glu Ile Phe Asn
         220                 225                 230

 agg gtc tct gag cat ttc tca gcc atg ttc aaa agg aaa gct ttt gtg     1492
 Arg Val Ser Glu His Phe Ser Ala Met Phe Lys Arg Lys Ala Phe Val
     235                 240                 245

 cac tgg tac acc agc gaa ggg atg gac ata aac gaa ttt ggg gaa gct     1540
 His Trp Tyr Thr Ser Glu Gly Met Asp Ile Asn Glu Phe Gly Glu Ala
 250                 255                 260                 265

 gaa aat aac atc cat gat ttg gta tcc gag tac caa caa ttt caa gat     1588
 Glu Asn Asn Ile His Asp Leu Val Ser Glu Tyr Gln Gln Phe Gln Asp
                 270                 275                 280

 gcc aaa gca gtt cta gag gaa gat gaa gag gtc acg gag gag gca gaa     1636
 Ala Lys Ala Val Leu Glu Glu Asp Glu Glu Val Thr Glu Glu Ala Glu
             285                 290                 295

 atg gag cca gaa gat aag gga cat taa ctgtg agagaagctg tgccgcggag     1688
 Met Glu Pro Glu Asp Lys Gly His 
         300                 305

 tcgcttacag aacagtttct cattagatga gtgtttctcc tgcagcactc caaaacccac   1748

 tctgcactgc agcacagtga atgatatgca ctcaccatta gcttcgacac agggactgag   1808

 ggagacaggt ggggagcagc tgacaggcat tagggtcttt gctgacatct actaaccttg   1868

 aagagtttga tgttcagtgc atacttatta acttaaaaaa atagcaaatt tattgtaaag   1928

 tgctcccttt gtttcaaagt gtttgccagg catccagact acacgtgtgg atttgcaggg   1988

 agccactgga gttggtgtta catttttata ctttagcagc actgataggc accctggaat   2048

 cctcacttgg tatccgaggg ctactaagac tctttcctta ggttctttcc tctgagcaaa   2108

 cactgactgg catcctgctt tccagtgcct gccagcctcc agaagagcca ggtgcctgac   2168

 tagtacatgg ggagctacag agccaaggtc aatgtgagtc aacatccact agaaatatcc   2228

 atgttgtgta gacctgtgca tacaacatgc taactggaaa agaggaaaaa agaaaagcca   2288

 cagtcctctc cacaaaaata cctggtccaa acaagaaaaa caaaaagaca agcaaaacta   2348

 aagaactgca gtcttctgat ctttatttct gaagagctag cctttaacat acatgtttat   2408

 atagtttaaa tttcttacta ctgttagatc ccaggaattc attaataatc atccttggct   2468

 ttccttttaa aggctatttt gaaatggtct tttcactttc attcagtcat caccccccaa   2528

 aatgctctgc agcctctctg ctctttgaga aaggggcaca ccatgcgctc ggcaaccatt   2588

 caaatgcagg gaattaaggc agcaatggct ccaggtgtcc ttctcagtta tggaggacat   2648

 cgtctccata gggaactttt acagttcaaa ttaatttgca gaagttgcca taaatgtttg   2708

 g                                                                   2709




      <210> 250
      <211> 2295
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(1249)

      <400> 250
 ttaaaacatt aacttttaga aaaacaagta ggctgacttt ttcctatttt tctacacagg     60

 taggaaatat gtgccccgag cagtcttggt ggacctagaa cctgggacg    atg gac     115
                                                          Met Asp
                                                            1

 agc att cga tct agc aaa tta gga gct ctc ttt caa ccc gac agt ttt      163
 Ser Ile Arg Ser Ser Lys Leu Gly Ala Leu Phe Gln Pro Asp Ser Phe
           5                  10                  15

 gtc cat ggt aac tct ggg gct ggc aac aac tgg gcc aaa ggc cac tac      211
 Val His Gly Asn Ser Gly Ala Gly Asn Asn Trp Ala Lys Gly His Tyr
      20                  25                  30

 acg gag gga gcc gag ctg atc gag aat gtc cta gag gtg gtg agg cac      259
 Thr Glu Gly Ala Glu Leu Ile Glu Asn Val Leu Glu Val Val Arg His
  35                  40                  45                  50

 gag agt gag agc tgt gac tgc ctg cag ggc ttc cag atc gtc cac tcc      307
 Glu Ser Glu Ser Cys Asp Cys Leu Gln Gly Phe Gln Ile Val His Ser
                  55                  60                  65

 ctg ggc ggg ggc aca ggc tcc ggg atg ggc act ctg ctc atg aac aag      355
 Leu Gly Gly Gly Thr Gly Ser Gly Met Gly Thr Leu Leu Met Asn Lys
              70                  75                  80

 att aga gag gag tac ccg gac cgg atc atg aat tcc ttc agc gtc atg      403
 Ile Arg Glu Glu Tyr Pro Asp Arg Ile Met Asn Ser Phe Ser Val Met
          85                  90                  95

 cct tct ccc aag gtg tcg gac acg gtg gtg gag ccc tac aac gcg gtt      451
 Pro Ser Pro Lys Val Ser Asp Thr Val Val Glu Pro Tyr Asn Ala Val
     100                 105                 110

 ctg tct atc cac cag ctg att gag aat gca gat gcc tgt ttc tgc att      499
 Leu Ser Ile His Gln Leu Ile Glu Asn Ala Asp Ala Cys Phe Cys Ile
 115                 120                 125                 130

 gac aat gag gcc ctc tat gac atc tgc ttc cgt acc ctg aag ctg acg      547
 Asp Asn Glu Ala Leu Tyr Asp Ile Cys Phe Arg Thr Leu Lys Leu Thr
                 135                 140                 145

 aca ccc acc tat ggg gat ctc aac cac cta gtg tcc ttg acc atg agc      595
 Thr Pro Thr Tyr Gly Asp Leu Asn His Leu Val Ser Leu Thr Met Ser
             150                 155                 160

 ggc ata acc acc tcc ctc cgg ttc ccg ggt cag ctc aac gca gac ctg      643
 Gly Ile Thr Thr Ser Leu Arg Phe Pro Gly Gln Leu Asn Ala Asp Leu
         165                 170                 175

 cgc aag ctg gcg gtg aac atg gtc ccc ttc ccc cgc ctg cac ttc ttt      691
 Arg Lys Leu Ala Val Asn Met Val Pro Phe Pro Arg Leu His Phe Phe
     180                 185                 190

 atg ccc ggc ttt gcc cca ctc acg gcc cag ggc agc cag cag tac cga      739
 Met Pro Gly Phe Ala Pro Leu Thr Ala Gln Gly Ser Gln Gln Tyr Arg
 195                 200                 205                 210

 gcc ctc tcc gtg gcc gag ctc acc cag cag atg ttc gat gcc cgc aat      787
 Ala Leu Ser Val Ala Glu Leu Thr Gln Gln Met Phe Asp Ala Arg Asn
                 215                 220                 225

 acc atg gct gcc tgt gac ctc cgc cgt ggc cgc tac ctc aca gtg gcc      835
 Thr Met Ala Ala Cys Asp Leu Arg Arg Gly Arg Tyr Leu Thr Val Ala
             230                 235                 240

 tgc att ttc cgg ggc aag atg tcc acc aag gaa gtg gac cag caa ctg      883
 Cys Ile Phe Arg Gly Lys Met Ser Thr Lys Glu Val Asp Gln Gln Leu
         245                 250                 255

 ctc tcc gtg cag acc agg aac agc agc tgc ttt gtg gag tgg att ccc      931
 Leu Ser Val Gln Thr Arg Asn Ser Ser Cys Phe Val Glu Trp Ile Pro
     260                 265                 270

 aac aac gtc aag gtg gct gtc tgc gac atc ccg ccc cgg ggg ctg agc      979
 Asn Asn Val Lys Val Ala Val Cys Asp Ile Pro Pro Arg Gly Leu Ser
 275                 280                 285                 290

 atg gcc gcc acc ttc att ggc aac aac acg gcc atc caa gag atc ttt     1027
 Met Ala Ala Thr Phe Ile Gly Asn Asn Thr Ala Ile Gln Glu Ile Phe
                 295                 300                 305

 aat agg gtc tct gag cat ttc tca gcc atg ttc aaa agg aaa gct ttt     1075
 Asn Arg Val Ser Glu His Phe Ser Ala Met Phe Lys Arg Lys Ala Phe
             310                 315                 320

 gtg cac tgg tac acc agc gaa ggg atg gac ata aac gaa ttt ggg gaa     1123
 Val His Trp Tyr Thr Ser Glu Gly Met Asp Ile Asn Glu Phe Gly Glu
         325                 330                 335

 gct gaa aat aac atc cat gat ttg gta tcc gag tac caa caa ttt caa     1171
 Ala Glu Asn Asn Ile His Asp Leu Val Ser Glu Tyr Gln Gln Phe Gln
     340                 345                 350

 gat gcc aaa gca gtt cta gag gaa gat gaa gag gtc acg gag gag gca     1219
 Asp Ala Lys Ala Val Leu Glu Glu Asp Glu Glu Val Thr Glu Glu Ala
 355                 360                 365                 370

 gaa atg gag cca gaa gat aag gga cat taa c tgtgagagaa gctgtgccgc     1270
 Glu Met Glu Pro Glu Asp Lys Gly His 
                 375

 ggagtcgctt acagaacagt ttctcattag atgagtgttt ctcctgcagc actccaaaac   1330

 ccactctgca ctgcagcaca gtgaatgata tgcactcacc attagcttcg acacagggac   1390

 tgagggagac aggtggggag cagctgacag gcattagggt ctttgctgac atctactaac   1450

 cttgaagagt ttgatgttca gtgcatactt attaacttaa aaaaatagca aatttattgt   1510

 aaagtgctcc ctttgtttca aagtgtttgc caggcatcca gactacacgt gtggatttgc   1570

 agggagccac tggagttggt gttacatttt tatactttag cagcactgat aggcaccctg   1630

 gaatcctcac ttggtatccg agggctacta agactctttc cttaggttct ttcctctgag   1690

 caaacactga ctggcatcct gctttccagt gcctgccagc ctccagaaga gccaggtgcc   1750

 tgactagtac atggggagct acagagccaa ggtcaatgtg agtcaacatc cactagaaat   1810

 atccatgttg tgtagacctg tgcatacaac atgctaactg gaaaagagga aaaaagaaaa   1870

 gccacagtcc tctccacaaa aatacctggt ccaaacaaga aaaacaaaaa gacaagcaaa   1930

 actaaagaac tgcagtcttc tgatctttat ttctgaagag ctagccttta acatacatgt   1990

 ttatatagtt taaatttctt actactgtta gatcccagga attcattaat aatcatcctt   2050

 ggctttcctt ttaaaggcta ttttgaaatg gtcttttcac tttcattcag tcatcacccc   2110

 ccaaaatgct ctgcagcctc tctgctcttt gagaaagggg cacaccatgc gctcggcaac   2170

 cattcaaatg cagggaatta aggcagcaat ggctccaggt gtccttctca gttatggagg   2230

 acatcgtctc catagggaac ttttacagtt caaattaatt tgcagaagtt gccataaatg   2290

 tttgg                                                               2295




      <210> 251
      <211> 1529
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1529)

      <400> 251
 aaggatcctt aattaaatta atcccccccc cccccgccag tcagtccgga ggctgcggct     60

 gcagaagtac cgcctgcgga gtaactgcaa ag  atg ctg tcc gtg cgc gtt gct     113
                                      Met Leu Ser Val Arg Val Ala
                                        1               5

 gcg gcc gtg gtc cgc gcc ctt cct cgg cgg gcc gga ctg gtc tcc aga      161
 Ala Ala Val Val Arg Ala Leu Pro Arg Arg Ala Gly Leu Val Ser Arg
          10                  15                  20

 aat gct ttg ggt tca tct ttc att gct gca agg aac ttc cat gcc tct      209
 Asn Ala Leu Gly Ser Ser Phe Ile Ala Ala Arg Asn Phe His Ala Ser
      25                  30                  35

 aac act cat ctt caa aag act ggg act gct gag atg tcc tct att ctt      257
 Asn Thr His Leu Gln Lys Thr Gly Thr Ala Glu Met Ser Ser Ile Leu
  40                  45                  50                  55

 gaa gag cgt att ctt gga gct gat acc tct gtt gat ctt gaa gaa act      305
 Glu Glu Arg Ile Leu Gly Ala Asp Thr Ser Val Asp Leu Glu Glu Thr
                  60                  65                  70

 ggg cgt gtc tta agt att ggt gat ggt att gcc cgc gta cat ggg ctg      353
 Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala Arg Val His Gly Leu
              75                  80                  85

 agg aat gtt caa gca gaa gaa atg gta gag ttt tct tca ggc tta aag      401
 Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe Ser Ser Gly Leu Lys
          90                  95                 100

 ggt atg tcc ttg aac ttg gaa cct gac aat gtt ggt gtt gtc gtg ttt      449
 Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val Gly Val Val Val Phe
     105                 110                 115

 gga aat gat aaa cta att aag gaa gga gat ata gtg aag agg aca gga      497
 Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile Val Lys Arg Thr Gly
 120                 125                 130                 135

 gcc att gtg gac gtt cca gtt ggt gag gag ctg ttg ggt cgt gta gtt      545
 Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu Leu Gly Arg Val Val
                 140                 145                 150

 gat gcc ctt ggt aat gct att gat gga aag ggt cca att ggt tcc aag      593
 Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Gly Pro Ile Gly Ser Lys
             155                 160                 165

 acg cgt agg cga gtt ggt ctg aaa gcc ccc ggt atc att cct cga att      641
 Thr Arg Arg Arg Val Gly Leu Lys Ala Pro Gly Ile Ile Pro Arg Ile
         170                 175                 180

 tca gtg cgg gaa cca atg cag act ggc att aag gct gtg gat agc ttg      689
 Ser Val Arg Glu Pro Met Gln Thr Gly Ile Lys Ala Val Asp Ser Leu
     185                 190                 195

 gtg cca att agg cgt ggt cag cgt gaa ctg att att ggt gac cga cag      737
 Val Pro Ile Arg Arg Gly Gln Arg Glu Leu Ile Ile Gly Asp Arg Gln
 200                 205                 210                 215

 act ggg aaa acc tca att gct att gac aca atc att aac cag aaa cgt      785
 Thr Gly Lys Thr Ser Ile Ala Ile Asp Thr Ile Ile Asn Gln Lys Arg
                 220                 225                 230

 ttc aat gat gga tct gat gaa aag aag aag ctg tac tgt att tat gtt      833
 Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu Tyr Cys Ile Tyr Val
             235                 240                 245

 gct att ggt caa aag aga tcc act gtt gcc cag ttg gtg aag aga ctt      881
 Ala Ile Gly Gln Lys Arg Ser Thr Val Ala Gln Leu Val Lys Arg Leu
         250                 255                 260

 aca gat gca gat gcc atg aag tac acc att gtg gtg tcg gct acg gcc      929
 Thr Asp Ala Asp Ala Met Lys Tyr Thr Ile Val Val Ser Ala Thr Ala
     265                 270                 275

 tcg gat gct gcc cca ctt cag tac ctg gct cct tac tct ggc tgt tcc      977
 Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro Tyr Ser Gly Cys Ser
 280                 285                 290                 295

 atg gga gag tat ttt aga gac aat ggc aaa cat gct ttg atc atc tat     1025
 Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His Ala Leu Ile Ile Tyr
                 300                 305                 310

 gac gac tta tcc aaa cag atc ttc ttg gaa aca gaa ttg ttc tac aaa     1073
 Asp Asp Leu Ser Lys Gln Ile Phe Leu Glu Thr Glu Leu Phe Tyr Lys
             315                 320                 325

 ggt atc cgc cct gca att aac gtt ggt ctg tct gta tct cgt gtc gga     1121
 Gly Ile Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly
         330                 335                 340

 tcc gct gcc caa acc agg gct atg aag cag gta gca ggt acc atg aag     1169
 Ser Ala Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr Met Lys
     345                 350                 355

 ctg gaa ttg gct cag tat cgt gag gtt gct gct ttt gcc cag ttc ggt     1217
 Leu Glu Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly
 360                 365                 370                 375

 tct gac ctc gat gct gcc act caa caa ctt ttg agt cgt ggc gtg cgt     1265
 Ser Asp Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly Val Arg
                 380                 385                 390

 cta act gag ttg ctg aag caa gga cag tat tct ccc atg gct att gaa     1313
 Leu Thr Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu
             395                 400                 405

 gaa caa gtg gct gtt atc tat gcg ggt gta agg gga tat ctt gat aaa     1361
 Glu Gln Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys
         410                 415                 420

 ctg gag ccc agc aag att aca aag ttt gag aat gct ttc ttg tct cat     1409
 Leu Glu Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu Ser His
     425                 430                 435

 gtc gtc agc cag cac caa gcc ttg ttg ggc act atc agg gct gat gga     1457
 Val Val Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala Asp Gly
 440                 445                 450                 455

 aag atc tca gaa caa tca gat gca aag ctg aaa gag att gta aca aat     1505
 Lys Ile Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Thr Asn
                 460                 465                 470

 ttc ttg gct gga ttt gaa gct taa                                     1529
 Phe Leu Ala Gly Phe Glu Ala 
             475





      <210> 252
      <211> 1523
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (93)..(1523)

      <400> 252
 aaggatcctt aattaaatta atcccccccc cccccgccag tcagtccgga ggctgcggct     60

 gcagaagtac cgcctgcgga gtaactgcaa ag  atg ctg tcc gtg cgc gtt gct     113
                                      Met Leu Ser Val Arg Val Ala
                                        1               5

 gcg gcc gtg gtc cgc gcc ctt cct cgg cgg gcc gga ctg gtc tcc aga      161
 Ala Ala Val Val Arg Ala Leu Pro Arg Arg Ala Gly Leu Val Ser Arg
          10                  15                  20

 aat gct ttg ggt tca tct ttc att gct gca agg aac ttc cat gcc tct      209
 Asn Ala Leu Gly Ser Ser Phe Ile Ala Ala Arg Asn Phe His Ala Ser
      25                  30                  35

 aac act cat ctt caa aag act ggg act gct gag atg tcc tct att ctt      257
 Asn Thr His Leu Gln Lys Thr Gly Thr Ala Glu Met Ser Ser Ile Leu
  40                  45                  50                  55

 gaa gag cgt att ctt gga gct gat acc tct gtt gat ctt gaa gaa act      305
 Glu Glu Arg Ile Leu Gly Ala Asp Thr Ser Val Asp Leu Glu Glu Thr
                  60                  65                  70

 ggg cgt gtc tta agt att ggt gat ggt att gcc cgc gta cat ggg ctg      353
 Gly Arg Val Leu Ser Ile Gly Asp Gly Ile Ala Arg Val His Gly Leu
              75                  80                  85

 agg aat gtt caa gca gaa gaa atg gta gag ttt tct tca ggc tta aag      401
 Arg Asn Val Gln Ala Glu Glu Met Val Glu Phe Ser Ser Gly Leu Lys
          90                  95                 100

 ggt atg tcc ttg aac ttg gaa cct gac aat gtt ggt gtt gtc gtg ttt      449
 Gly Met Ser Leu Asn Leu Glu Pro Asp Asn Val Gly Val Val Val Phe
     105                 110                 115

 gga aat gat aaa cta att aag gaa gga gat ata gtg aag agg aca gga      497
 Gly Asn Asp Lys Leu Ile Lys Glu Gly Asp Ile Val Lys Arg Thr Gly
 120                 125                 130                 135

 gcc att gtg gac gtt cca gtt ggt gag gag ctg ttg ggt cgt gta gtt      545
 Ala Ile Val Asp Val Pro Val Gly Glu Glu Leu Leu Gly Arg Val Val
                 140                 145                 150

 gat gcc ctt ggt aat gct att gat gga aag gag gcc aca tgt gcc tca      593
 Asp Ala Leu Gly Asn Ala Ile Asp Gly Lys Glu Ala Thr Cys Ala Ser
             155                 160                 165

 caa cga cgt ata ggc gag aaa acc tca att gct att gac aca atc att      641
 Gln Arg Arg Ile Gly Glu Lys Thr Ser Ile Ala Ile Asp Thr Ile Ile
         170                 175                 180

 aac cag aaa cgt ttc aat gat gga tct gat gaa aag aag aag ctg tac      689
 Asn Gln Lys Arg Phe Asn Asp Gly Ser Asp Glu Lys Lys Lys Leu Tyr
     185                 190                 195

 tgt att tat gtt gct att ggt caa aag aga tcc act gtt gcc cag ttg      737
 Cys Ile Tyr Val Ala Ile Gly Gln Lys Arg Ser Thr Val Ala Gln Leu
 200                 205                 210                 215

 gtg aag aga ctt aca gat gca gat gcc atg aag tac acc att gtg gtg      785
 Val Lys Arg Leu Thr Asp Ala Asp Ala Met Lys Tyr Thr Ile Val Val
                 220                 225                 230

 tcg gct acg gcc tcg gat gct gcc cca ctt cag tac ctg gct cct tac      833
 Ser Ala Thr Ala Ser Asp Ala Ala Pro Leu Gln Tyr Leu Ala Pro Tyr
             235                 240                 245

 tct ggc tgt tcc atg gga gag tat ttt aga gac aat ggc aaa cat gct      881
 Ser Gly Cys Ser Met Gly Glu Tyr Phe Arg Asp Asn Gly Lys His Ala
         250                 255                 260

 ttg atc atc tat gac gac tta tcc aaa cag aga gca gcc aaa atg aac      929
 Leu Ile Ile Tyr Asp Asp Leu Ser Lys Gln Arg Ala Ala Lys Met Asn
     265                 270                 275

 gat gct ttt ggt ggt ggc tcc ttg act gct ttg cca gtc ata gaa aca      977
 Asp Ala Phe Gly Gly Gly Ser Leu Thr Ala Leu Pro Val Ile Glu Thr
 280                 285                 290                 295

 cag gct ggt gat gtg tct gct tac att cca aca aat gtc att tcc atc     1025
 Gln Ala Gly Asp Val Ser Ala Tyr Ile Pro Thr Asn Val Ile Ser Ile
                 300                 305                 310

 act gac gga cag atc ttc ttg gaa aca gaa ttg ttc tac aaa ggt atc     1073
 Thr Asp Gly Gln Ile Phe Leu Glu Thr Glu Leu Phe Tyr Lys Gly Ile
             315                 320                 325

 cgc cct gca att aac gtt ggt ctg tct gta tct cgt gtc gga tcc gct     1121
 Arg Pro Ala Ile Asn Val Gly Leu Ser Val Ser Arg Val Gly Ser Ala
         330                 335                 340

 gcc caa acc agg gct atg aag cag gta gca ggt acc atg aag ctg gaa     1169
 Ala Gln Thr Arg Ala Met Lys Gln Val Ala Gly Thr Met Lys Leu Glu
     345                 350                 355

 ttg gct cag tat cgt gag gtt gct gct ttt gcc cag ttc ggt tct gac     1217
 Leu Ala Gln Tyr Arg Glu Val Ala Ala Phe Ala Gln Phe Gly Ser Asp
 360                 365                 370                 375

 ctc gat gct gcc act caa caa ctt ttg agt cgt ggc gtg cgt cta act     1265
 Leu Asp Ala Ala Thr Gln Gln Leu Leu Ser Arg Gly Val Arg Leu Thr
                 380                 385                 390

 gag ttg ctg aag caa gga cag tat tct ccc atg gct att gaa gaa caa     1313
 Glu Leu Leu Lys Gln Gly Gln Tyr Ser Pro Met Ala Ile Glu Glu Gln
             395                 400                 405

 gtg gct gtt atc tat gcg ggt gta agg gga tat ctt gat aaa ctg gag     1361
 Val Ala Val Ile Tyr Ala Gly Val Arg Gly Tyr Leu Asp Lys Leu Glu
         410                 415                 420

 ccc agc aag att aca aag ttt gag aat gct ttc ttg tct cat gtc gtc     1409
 Pro Ser Lys Ile Thr Lys Phe Glu Asn Ala Phe Leu Ser His Val Val
     425                 430                 435

 agc cag cac caa gcc ttg ttg ggc act atc agg gct gat gga aag atc     1457
 Ser Gln His Gln Ala Leu Leu Gly Thr Ile Arg Ala Asp Gly Lys Ile
 440                 445                 450                 455

 tca gaa caa tca gat gca aag ctg aaa gag att gta aca aat ttc ttg     1505
 Ser Glu Gln Ser Asp Ala Lys Leu Lys Glu Ile Val Thr Asn Phe Leu
                 460                 465                 470

 gct gga ttt gaa gct taa                                             1523
 Ala Gly Phe Glu Ala 
             475





      <210> 253
      <211> 750
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (122)..(700)

      <400> 253
 tgacgcggcg ttagtattgg ccgtgtaccc gaaaaactga ttgactgggc tggcgttaac     60

 tgtgcggagg caggatttcc ctggggaaag tcttcactca gagcttcgct gacagccaag    120

 g    atg gca agc aag ggg ccc tcg gcc tct gca tct cct gag aac tcc     166
      Met Ala Ser Lys Gly Pro Ser Ala Ser Ala Ser Pro Glu Asn Ser
        1               5                  10                  15

 agt gca ggg ggg ccc agt ggg agc agc aat ggc gct ggc gag agc gga      214
 Ser Ala Gly Gly Pro Ser Gly Ser Ser Asn Gly Ala Gly Glu Ser Gly
                  20                  25                  30

 ggg cag gac agc act ttc gag tgc aac atc tgc ttg gac aca gcc aag      262
 Gly Gln Asp Ser Thr Phe Glu Cys Asn Ile Cys Leu Asp Thr Ala Lys
              35                  40                  45

 gat gcc gtc atc agc ctg tgt ggc cac ctc ttc tgt tgg ccg tgt tta      310
 Asp Ala Val Ile Ser Leu Cys Gly His Leu Phe Cys Trp Pro Cys Leu
          50                  55                  60

 cat cag tgg ttg gag acc aga cct aac aga cag gtg tgt cct gtt tgc      358
 His Gln Trp Leu Glu Thr Arg Pro Asn Arg Gln Val Cys Pro Val Cys
      65                  70                  75

 aaa gct ggc atc agc cga gac aag gtc atc ccc ctc tat gga agg ggc      406
 Lys Ala Gly Ile Ser Arg Asp Lys Val Ile Pro Leu Tyr Gly Arg Gly
  80                  85                  90                  95

 agc act ggg caa cag gac ccc aga gag aag acc cct cct cgt cct caa      454
 Ser Thr Gly Gln Gln Asp Pro Arg Glu Lys Thr Pro Pro Arg Pro Gln
                 100                 105                 110

 gga cag agg cca gag ccg gag aat aga ggg gga ttt caa gga ttt gga      502
 Gly Gln Arg Pro Glu Pro Glu Asn Arg Gly Gly Phe Gln Gly Phe Gly
             115                 120                 125

 ttt gga gat ggt ggc ttc cag atg tct ttt gga att ggg gca ttt ccc      550
 Phe Gly Asp Gly Gly Phe Gln Met Ser Phe Gly Ile Gly Ala Phe Pro
         130                 135                 140

 ttt ggg ata ttt gcc aca gca ttt aat ata aat gat ggg cgg cct cct      598
 Phe Gly Ile Phe Ala Thr Ala Phe Asn Ile Asn Asp Gly Arg Pro Pro
     145                 150                 155

 cca gct gtc cct ggg aca ccc cag tat gtg gac gag cag ttc ctg tca      646
 Pro Ala Val Pro Gly Thr Pro Gln Tyr Val Asp Glu Gln Phe Leu Ser
 160                 165                 170                 175

 cgc ctc ttc cta ttt gtg gcc ctg gtg atc atg ttc tgg ctc ctg att      694
 Arg Leu Phe Leu Phe Val Ala Leu Val Ile Met Phe Trp Leu Leu Ile
                 180                 185                 190

 gcc taa tgctgggctc ctgcctacat ccgtggcagg gctctggact ggtgacgtgc       750
 Ala 






      <210> 254
      <211> 2168
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (57)..(1634)

      <400> 254
 aaggatcctt aattaaatta atcccccccc cccccccccc gatgtgacaa tccaag         56                                                                 
 atg gcg gtg ccc ggc gag gcg gag gag gag gcg aca gtt tac ctg gta      104
 Met Ala Val Pro Gly Glu Ala Glu Glu Glu Ala Thr Val Tyr Leu Val
   1               5                  10                  15

 gtg agc ggt atc ccc tcc gtg ttg cgc tcg gcc cat tta cgg agc tat      152
 Val Ser Gly Ile Pro Ser Val Leu Arg Ser Ala His Leu Arg Ser Tyr
              20                  25                  30

 ttt agc cag ttc cga gaa gag cgc ggc ggt ggc ttc ctc tgt ttc cac      200
 Phe Ser Gln Phe Arg Glu Glu Arg Gly Gly Gly Phe Leu Cys Phe His
          35                  40                  45

 tac cgg cat cgg cct gag cgg gcc cct ccg cag gcc gct cct aac tct      248
 Tyr Arg His Arg Pro Glu Arg Ala Pro Pro Gln Ala Ala Pro Asn Ser
      50                  55                  60

 gcc cta att cct acc gac cca gcc gct gag ggc cag ctt ctc tct cag      296
 Ala Leu Ile Pro Thr Asp Pro Ala Ala Glu Gly Gln Leu Leu Ser Gln
  65                  70                  75                  80

 act tcg gcc acc gat gtc cgg cct ctc tcc act cga gac tct act cca      344
 Thr Ser Ala Thr Asp Val Arg Pro Leu Ser Thr Arg Asp Ser Thr Pro
                  85                  90                  95

 atc cag acc cgc acc tgc tgc tgc gtc atc tcg gta agg ggg ttg gct      392
 Ile Gln Thr Arg Thr Cys Cys Cys Val Ile Ser Val Arg Gly Leu Ala
             100                 105                 110

 caa gct cag agg ctt att cgc atg tac tcg ggc cgc cgg tgg ctg gat      440
 Gln Ala Gln Arg Leu Ile Arg Met Tyr Ser Gly Arg Arg Trp Leu Asp
         115                 120                 125

 tct cac ggg act tgg cta ccg ggt cgc tgt ctc atc cgc aga ctt cgg      488
 Ser His Gly Thr Trp Leu Pro Gly Arg Cys Leu Ile Arg Arg Leu Arg
     130                 135                 140

 cta cct acg gag gca tca ggt ctg ggc tcc ttt ccc ttc aag acc cgg      536
 Leu Pro Thr Glu Ala Ser Gly Leu Gly Ser Phe Pro Phe Lys Thr Arg
 145                 150                 155                 160

 aag gaa ctg cag agt tgg aag gca gag aat gaa gcc ttc acc ctg gct      584
 Lys Glu Leu Gln Ser Trp Lys Ala Glu Asn Glu Ala Phe Thr Leu Ala
                 165                 170                 175

 gac ctg aag caa ctg ccg gag ctg aac cca cca gtg ctg atg ccc aga      632
 Asp Leu Lys Gln Leu Pro Glu Leu Asn Pro Pro Val Leu Met Pro Arg
             180                 185                 190

 ggg aat gtg ggg act ccc ctg cgg gtc ttt ttg gag ttg atc cgg gcc      680
 Gly Asn Val Gly Thr Pro Leu Arg Val Phe Leu Glu Leu Ile Arg Ala
         195                 200                 205

 tgc cgc cta ccc cct cgg atc atc acc cag ctg cag ctc cag ttc ccc      728
 Cys Arg Leu Pro Pro Arg Ile Ile Thr Gln Leu Gln Leu Gln Phe Pro
     210                 215                 220

 aag aca ggt tcc tcc cgg cgc tac ggc aat gtg cct ttt gag tat gag      776
 Lys Thr Gly Ser Ser Arg Arg Tyr Gly Asn Val Pro Phe Glu Tyr Glu
 225                 230                 235                 240

 gac tca gag act gtg gag cag gaa gag ctt gtg tat aca gca gag ggt      824
 Asp Ser Glu Thr Val Glu Gln Glu Glu Leu Val Tyr Thr Ala Glu Gly
                 245                 250                 255

 gaa gaa ata ccc caa gga acc tac ctg gca gat ata cca gcc agc ccc      872
 Glu Glu Ile Pro Gln Gly Thr Tyr Leu Ala Asp Ile Pro Ala Ser Pro
             260                 265                 270

 tgt gga gag cct gag gaa gaa gtg ggg aag gaa gag gaa gaa gag tct      920
 Cys Gly Glu Pro Glu Glu Glu Val Gly Lys Glu Glu Glu Glu Glu Ser
         275                 280                 285

 cac tca gat gag gac gat gac cgg ggt gag gaa tgg gaa cgg cat gaa      968
 His Ser Asp Glu Asp Asp Asp Arg Gly Glu Glu Trp Glu Arg His Glu
     290                 295                 300

 gcg ctg cat gag gac gtg acc ggg cag gag cgg acc act gag cag ctc     1016
 Ala Leu His Glu Asp Val Thr Gly Gln Glu Arg Thr Thr Glu Gln Leu
 305                 310                 315                 320

 ttt gag gag gag att gag ctc aag tgg gag aag ggt ggc tct ggc ctg     1064
 Phe Glu Glu Glu Ile Glu Leu Lys Trp Glu Lys Gly Gly Ser Gly Leu
                 325                 330                 335

 gtg ttt tat act gat gcc cag ttc tgg cag gag gaa gaa gga gat ttt     1112
 Val Phe Tyr Thr Asp Ala Gln Phe Trp Gln Glu Glu Glu Gly Asp Phe
             340                 345                 350

 gat gaa cag aca gcc gat gac tgg gat gtg gac atg agt gtg tac tat     1160
 Asp Glu Gln Thr Ala Asp Asp Trp Asp Val Asp Met Ser Val Tyr Tyr
         355                 360                 365

 gac aga gat ggt gga gac aag gat gcc cga gac tct gtc caa atg cgt     1208
 Asp Arg Asp Gly Gly Asp Lys Asp Ala Arg Asp Ser Val Gln Met Arg
     370                 375                 380

 ctg gaa cag aga ctc cga gat gga cag gaa gat ggc tct gtg atc gaa     1256
 Leu Glu Gln Arg Leu Arg Asp Gly Gln Glu Asp Gly Ser Val Ile Glu
 385                 390                 395                 400

 cgc cag gtg ggc acc ttt gag cgc cac acc aag ggc att ggg cgg aag     1304
 Arg Gln Val Gly Thr Phe Glu Arg His Thr Lys Gly Ile Gly Arg Lys
                 405                 410                 415

 gtg atg gag cgg cag ggc tgg gct gag ggc cag ggc ctg ggc tgc agg     1352
 Val Met Glu Arg Gln Gly Trp Ala Glu Gly Gln Gly Leu Gly Cys Arg
             420                 425                 430

 tgc tca ggg gtg cct gag gcc ctg gat agt gat ggc caa cac ccc aga     1400
 Cys Ser Gly Val Pro Glu Ala Leu Asp Ser Asp Gly Gln His Pro Arg
         435                 440                 445

 tgc aag cgt gga ttg ggg tac cat gga gag aag cta cag cca ttt ggg     1448
 Cys Lys Arg Gly Leu Gly Tyr His Gly Glu Lys Leu Gln Pro Phe Gly
     450                 455                 460

 caa ctg aag agg ccc cgt aga aat ggc ttg ggg ctc atc tcc acc atc     1496
 Gln Leu Lys Arg Pro Arg Arg Asn Gly Leu Gly Leu Ile Ser Thr Ile
 465                 470                 475                 480

 tat gat gag cct cta ccc caa gac cag acg gag tca ctg ctc cgc cgc     1544
 Tyr Asp Glu Pro Leu Pro Gln Asp Gln Thr Glu Ser Leu Leu Arg Arg
                 485                 490                 495

 cag cca ccc acc agc atg aag ttt cgg aca gac atg gcc ttt gtg agg     1592
 Gln Pro Pro Thr Ser Met Lys Phe Arg Thr Asp Met Ala Phe Val Arg
             500                 505                 510

 ggt tcc agt tgt gct tca gac agc ccc tca ttg cct gac tga ccgggtt     1641
 Gly Ser Ser Cys Ala Ser Asp Ser Pro Ser Leu Pro Asp 
         515                 520                 525

 gggggcttcc tttcatagct acatgatgaa aaccctctgc cctggcctca tctaccactg   1701

 aagcagaaag gagtctggga gcagcagtct tcgtggctgg ttcagggtgt tttgttccga   1761

 gcctgcctgc ctgccggttc tatacctcag gggcattttt acaaaaagcc ccctcccgtc   1821

 ccctcccctt ggatattagg ggtaacgacc gcttgtcttt ggtctctaac cctaatctct   1881

 gggcttgccc tttgcctcct gcagaacttt gaaaagctgg gttgagtgag gctatcagca   1941

 cagccttcct tggggactct gaaggtgtcc ccacgaaggc cagaaagggg gaaagggacc   2001

 tgggcgagga gaggatttgt ggtgcttgga agagccggcc ttgggtgggc cctccaccgc   2061

 ctctaccctc actgggtggg actgccagcg gagagtccgc gggaggtggc ttgggtgtgc   2121

 gacgtcacgg aagaataaag acgtttacta ctggaaaaaa aaaaaaa                 2168




      <210> 255
      <211> 724
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (128)..(697)

      <400> 255
 ctgacatcac cacggcggca gccctttaaa cccctcaccc agccagcgcc ccatcctgtc     60

 tgtccgaacc cagacacaag tcttcactcc ttcctgcgag ccctgaggaa gccttctttc    120

 cccagac  atg gcc aac aag ggt cct tcc tat ggc atg agc cgc gaa gtg     169
          Met Ala Asn Lys Gly Pro Ser Tyr Gly Met Ser Arg Glu Val
            1               5                  10

 cag tcc aaa atc gag aag aag tat gac gag gag ctg gag gag cgg ctg      217
 Gln Ser Lys Ile Glu Lys Lys Tyr Asp Glu Glu Leu Glu Glu Arg Leu
  15                  20                  25                  30

 gtg gag tgg atc ata gtg cag tgt ggc cct gat gtg ggc cgc cca gac      265
 Val Glu Trp Ile Ile Val Gln Cys Gly Pro Asp Val Gly Arg Pro Asp
                  35                  40                  45

 cgt ggg cgc ttg ggc ttc cag gtc tgg ctg aag aat ggc gtg att ctg      313
 Arg Gly Arg Leu Gly Phe Gln Val Trp Leu Lys Asn Gly Val Ile Leu
              50                  55                  60

 agc aag ctg gtg aac agc ctg tac cct gat ggc tcc aag ccg gtg aag      361
 Ser Lys Leu Val Asn Ser Leu Tyr Pro Asp Gly Ser Lys Pro Val Lys
          65                  70                  75

 gtg ccc gag aac cca ccc tcc atg gtc ttc aag cag atg gag cag gtg      409
 Val Pro Glu Asn Pro Pro Ser Met Val Phe Lys Gln Met Glu Gln Val
      80                  85                  90

 gct cag ttc ctg aag gcg gct gag gac tat ggg gtc atc aag act gac      457
 Ala Gln Phe Leu Lys Ala Ala Glu Asp Tyr Gly Val Ile Lys Thr Asp
  95                 100                 105                 110

 atg ttc cag act gtt gac ctc ttt gaa ggc aaa gac atg gca gca gtg      505
 Met Phe Gln Thr Val Asp Leu Phe Glu Gly Lys Asp Met Ala Ala Val
                 115                 120                 125

 cag agg acc ctg atg gct ttg ggc agc ttg gca gtg acc aag aat gat      553
 Gln Arg Thr Leu Met Ala Leu Gly Ser Leu Ala Val Thr Lys Asn Asp
             130                 135                 140

 ggg cac tac cgt gga gat ccc aac tgg ttt atg aag aaa gcg cag gag      601
 Gly His Tyr Arg Gly Asp Pro Asn Trp Phe Met Lys Lys Ala Gln Glu
         145                 150                 155

 cat aag agg gaa ttc aca gag agc cag ctg cag gag gga aag cat gtc      649
 His Lys Arg Glu Phe Thr Glu Ser Gln Leu Gln Glu Gly Lys His Val
     160                 165                 170

 att ggc ctt aaa tgg gcc aga aca gaa ggg cct tcc aag ccg gtt taa      697
 Ile Gly Leu Lys Trp Ala Arg Thr Glu Gly Pro Ser Lys Pro Val 
 175                 180                 185

 caggtacgga caaccttgga gaaatcg                                        724




      <210> 256
      <211> 1411
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1150)

      <400> 256
 actaagg  atg cgg tcc cgg gtt ctg tgg ggc gct gcc cgg tgg ctc tgg      49
          Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp
            1               5                  10

 ccc cgc cgg gcc gtt ggc cca gcc cgc cgg ccc ctg agc tcc ggt agc       97
 Pro Arg Arg Ala Val Gly Pro Ala Arg Arg Pro Leu Ser Ser Gly Ser
  15                  20                  25                  30

 ccg ccg ctg gag gag ctg ttc gcc cgg ggc ggg ccc ttg cgg acc ttc      145
 Pro Pro Leu Glu Glu Leu Phe Ala Arg Gly Gly Pro Leu Arg Thr Phe
                  35                  40                  45

 ctc gag cgc cag gcg ggg tct gaa gcc cat ttg aag gtc agg agg ccc      193
 Leu Glu Arg Gln Ala Gly Ser Glu Ala His Leu Lys Val Arg Arg Pro
              50                  55                  60

 gag ttg ctg gcg gtg atc aaa ctg ctg aac gag aag gag cag gag ctg      241
 Glu Leu Leu Ala Val Ile Lys Leu Leu Asn Glu Lys Glu Gln Glu Leu
          65                  70                  75

 cgg gag act gag cac ttg ctg cac gat gag aat gaa gat tta agg aaa      289
 Arg Glu Thr Glu His Leu Leu His Asp Glu Asn Glu Asp Leu Arg Lys
      80                  85                  90

 ctt gca gag aat gaa atc act ttg tgt caa aaa gaa ata act cag ctg      337
 Leu Ala Glu Asn Glu Ile Thr Leu Cys Gln Lys Glu Ile Thr Gln Leu
  95                 100                 105                 110

 aag cat cag att atc tta ctt ttg gtt ccc tca gaa gaa aca gat gaa      385
 Lys His Gln Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu
                 115                 120                 125

 aat gat ttg atc ctg gaa gta act gca gga gtt gga ggt cag gag gca      433
 Asn Asp Leu Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gln Glu Ala
             130                 135                 140

 atg ttg ttt aca tca gag ata ttt gat atg tat cag caa tat gct gca      481
 Met Leu Phe Thr Ser Glu Ile Phe Asp Met Tyr Gln Gln Tyr Ala Ala
         145                 150                 155

 ttt aaa aga tgg cat ttt gaa acc ctg gaa tat ttt cca agt gaa cta      529
 Phe Lys Arg Trp His Phe Glu Thr Leu Glu Tyr Phe Pro Ser Glu Leu
     160                 165                 170

 ggt ggc ctt aga cat gca tct gcc agc att ggg ggt tca gaa gcc tat      577
 Gly Gly Leu Arg His Ala Ser Ala Ser Ile Gly Gly Ser Glu Ala Tyr
 175                 180                 185                 190

 agg cac atg aaa ttt gaa gga ggt gtt cac aga gta caa aga gtg cca      625
 Arg His Met Lys Phe Glu Gly Gly Val His Arg Val Gln Arg Val Pro
                 195                 200                 205

 aag aca gaa aag caa ggc cgc atc cat act agc acc atg act gta gca      673
 Lys Thr Glu Lys Gln Gly Arg Ile His Thr Ser Thr Met Thr Val Ala
             210                 215                 220

 ata tta ccc cag cct act gag att aat ctg gtg att aat ccg aaa gat      721
 Ile Leu Pro Gln Pro Thr Glu Ile Asn Leu Val Ile Asn Pro Lys Asp
         225                 230                 235

 ttg aga att gac act aag cga gcc agt gga gct ggg ggg cag cat gta      769
 Leu Arg Ile Asp Thr Lys Arg Ala Ser Gly Ala Gly Gly Gln His Val
     240                 245                 250

 aat acc acg gac agt gct gtc cgg ata gtt cat ctt cca aca ggt gtt      817
 Asn Thr Thr Asp Ser Ala Val Arg Ile Val His Leu Pro Thr Gly Val
 255                 260                 265                 270

 gtt tct gaa tgt caa caa gag aga tct cag ctg aaa aat aaa gag ctg      865
 Val Ser Glu Cys Gln Gln Glu Arg Ser Gln Leu Lys Asn Lys Glu Leu
                 275                 280                 285

 gct atg aca aag tta cgt gca aaa ctg tac agc atg cat cta gaa gaa      913
 Ala Met Thr Lys Leu Arg Ala Lys Leu Tyr Ser Met His Leu Glu Glu
             290                 295                 300

 gaa ata aat aaa aga cag aat gct aga aaa att cag att gga agt aaa      961
 Glu Ile Asn Lys Arg Gln Asn Ala Arg Lys Ile Gln Ile Gly Ser Lys
         305                 310                 315

 gga aga tca gag aaa ata aga aca tat aat ttt cca cag aac cgg gtc     1009
 Gly Arg Ser Glu Lys Ile Arg Thr Tyr Asn Phe Pro Gln Asn Arg Val
     320                 325                 330

 aca gat cac aga ata aac aag acg ctg cat gat ctt gaa act ttt atg     1057
 Thr Asp His Arg Ile Asn Lys Thr Leu His Asp Leu Glu Thr Phe Met
 335                 340                 345                 350

 caa gga gat tat cta ctg gat gaa ctt gta cag tca ttg aag gaa tac     1105
 Gln Gly Asp Tyr Leu Leu Asp Glu Leu Val Gln Ser Leu Lys Glu Tyr
                 355                 360                 365

 gcc gat tat gaa tct tta gta gaa att att tcc caa aaa gtt taa gtt     1153
 Ala Asp Tyr Glu Ser Leu Val Glu Ile Ile Ser Gln Lys Val 
             370                 375                 380

 gatttgttat ttatagactt tcgtagctta gaaaaattct acagtacatc cacatagggt   1213

 gaaagtaccc ttactctctt gaaaaacgtt gagttaacac agttggaggt aatatgcata   1273

 ttctgaagtc atagataatt tacacagatc tctctcaatg cattagcaaa aatcatacaa   1333

 tatacagatg gtcctcgatt tacattgtgg ttaattccca ataaacccat cataagttaa   1393

 aaatgcaaaa aaaaaaaa                                                 1411




      <210> 257
      <211> 1303
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(1042)

      <400> 257
 actaagg  atg cgg tcc cgg gtt ctg tgg ggc gct gcc cgg tgg ctc tgg      49
          Met Arg Ser Arg Val Leu Trp Gly Ala Ala Arg Trp Leu Trp
            1               5                  10

 ccc cgc cgg gcc gtt ggc cca gcc cgc cgg ccc ctg agc tcc ggt agc       97
 Pro Arg Arg Ala Val Gly Pro Ala Arg Arg Pro Leu Ser Ser Gly Ser
  15                  20                  25                  30

 ccg ccg ctg gag gag ctg ttc gcc cgg ggc ggg ccc ttg cgg acc ttc      145
 Pro Pro Leu Glu Glu Leu Phe Ala Arg Gly Gly Pro Leu Arg Thr Phe
                  35                  40                  45

 ctc gag cgc cag gcg ggg tct gaa gcc cat ttg aag gtc agg agg ccc      193
 Leu Glu Arg Gln Ala Gly Ser Glu Ala His Leu Lys Val Arg Arg Pro
              50                  55                  60

 gag ttg ctg gcg gtg atc aaa ctg ctg aac gag aag gag cag gag ctg      241
 Glu Leu Leu Ala Val Ile Lys Leu Leu Asn Glu Lys Glu Gln Glu Leu
          65                  70                  75

 cgg gag act gag cac ttg ctg cac gat gag aat gaa gat tta agg aaa      289
 Arg Glu Thr Glu His Leu Leu His Asp Glu Asn Glu Asp Leu Arg Lys
      80                  85                  90

 ctt gca gag aat gaa atc act ttg tgt caa aaa gaa ata act cag ctg      337
 Leu Ala Glu Asn Glu Ile Thr Leu Cys Gln Lys Glu Ile Thr Gln Leu
  95                 100                 105                 110

 aag cat cag att atc tta ctt ttg gtt ccc tca gaa gaa aca gat gaa      385
 Lys His Gln Ile Ile Leu Leu Leu Val Pro Ser Glu Glu Thr Asp Glu
                 115                 120                 125

 aat gat ttg atc ctg gaa gta act gca gga gtt gga ggt ggc ctt aga      433
 Asn Asp Leu Ile Leu Glu Val Thr Ala Gly Val Gly Gly Gly Leu Arg
             130                 135                 140

 cat gca tct gcc agc att ggg ggt tca gaa gcc tat agg cac atg aaa      481
 His Ala Ser Ala Ser Ile Gly Gly Ser Glu Ala Tyr Arg His Met Lys
         145                 150                 155

 ttt gaa gga ggt gtt cac aga gta caa aga gtg cca aag aca gaa aag      529
 Phe Glu Gly Gly Val His Arg Val Gln Arg Val Pro Lys Thr Glu Lys
     160                 165                 170

 caa ggc cgc atc cat act agc acc atg act gta gca ata tta ccc cag      577
 Gln Gly Arg Ile His Thr Ser Thr Met Thr Val Ala Ile Leu Pro Gln
 175                 180                 185                 190

 cct act gag att aat ctg gtg att aat ccg aaa gat ttg aga att gac      625
 Pro Thr Glu Ile Asn Leu Val Ile Asn Pro Lys Asp Leu Arg Ile Asp
                 195                 200                 205

 act aag cga gcc agt gga gct ggg ggg cag cat gta aat acc acg gac      673
 Thr Lys Arg Ala Ser Gly Ala Gly Gly Gln His Val Asn Thr Thr Asp
             210                 215                 220

 agt gct gtc cgg ata gtt cat ctt cca aca ggt gtt gtt tct gaa tgt      721
 Ser Ala Val Arg Ile Val His Leu Pro Thr Gly Val Val Ser Glu Cys
         225                 230                 235

 caa caa gag aga tct cag ctg aaa aat aaa gag ctg gct atg aca aag      769
 Gln Gln Glu Arg Ser Gln Leu Lys Asn Lys Glu Leu Ala Met Thr Lys
     240                 245                 250

 tta cgt gca aaa ctg tac agc atg cat cta gaa gaa gaa ata aat aaa      817
 Leu Arg Ala Lys Leu Tyr Ser Met His Leu Glu Glu Glu Ile Asn Lys
 255                 260                 265                 270

 aga cag aat gct aga aaa att cag att gga agt aaa gga aga tca gag      865
 Arg Gln Asn Ala Arg Lys Ile Gln Ile Gly Ser Lys Gly Arg Ser Glu
                 275                 280                 285

 aaa ata aga aca tat aat ttt cca cag aac cgg gtc aca gat cac aga      913
 Lys Ile Arg Thr Tyr Asn Phe Pro Gln Asn Arg Val Thr Asp His Arg
             290                 295                 300

 ata aac aag acg ctg cat gat ctt gaa act ttt atg caa gga gat tat      961
 Ile Asn Lys Thr Leu His Asp Leu Glu Thr Phe Met Gln Gly Asp Tyr
         305                 310                 315

 cta ctg gat gaa ctt gta cag tca ttg aag gaa tac gcc gat tat gaa     1009
 Leu Leu Asp Glu Leu Val Gln Ser Leu Lys Glu Tyr Ala Asp Tyr Glu
     320                 325                 330

 tct tta gta gaa att att tcc caa aaa gtt taa gttgattt gttatttata     1060
 Ser Leu Val Glu Ile Ile Ser Gln Lys Val 
 335                 340

 gactttcgta gcttagaaaa attctacagt acatccacat agggtgaaag tacccttact   1120

 ctcttgaaaa acgttgagtt aacacagttg gaggtaatat gcatattctg aagtcataga   1180

 taatttacac agatctctct caatgcatta gcaaaaatca tacaatatac agatggtcct   1240

 cgatttacat tgtggttaat tcccaataaa cccatcataa gttaaaaatg caaaaaaaaa   1300

 aaa                                                                 1303




      <210> 258
      <211> 1575
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1152)

      <400> 258
  atg gaa aaa ctc aag cct gga gaa att aag agc ttt gcc cat ggt ccc      48
  Met Glu Lys Leu Lys Pro Gly Glu Ile Lys Ser Phe Ala His Gly Pro
    1               5                  10                  15

 aca ata gac agt caa gtg cat tct caa gcc ctg ctc cgc acc ctc tcc       96
 Thr Ile Asp Ser Gln Val His Ser Gln Ala Leu Leu Arg Thr Leu Ser
              20                  25                  30

 cta gtt acc ccc ggg act cag tct aaa gaa cgc cgg agc gct gag gtg      144
 Leu Val Thr Pro Gly Thr Gln Ser Lys Glu Arg Arg Ser Ala Glu Val
          35                  40                  45

 gta aat gac ttc ccc aag gtc acc tca gga aga ggg gct gcc ggg acc      192
 Val Asn Asp Phe Pro Lys Val Thr Ser Gly Arg Gly Ala Ala Gly Thr
      50                  55                  60

 aaa gct ggc ccc gcg ggt gcc tgg cct gtg ggc agc cgg acc gac acg      240
 Lys Ala Gly Pro Ala Gly Ala Trp Pro Val Gly Ser Arg Thr Asp Thr
  65                  70                  75                  80

 atg tgg cgg ctc cgc tgc aag gcc aag gac ggc acc cat gtt ttg cag      288
 Met Trp Arg Leu Arg Cys Lys Ala Lys Asp Gly Thr His Val Leu Gln
                  85                  90                  95

 ggg ctg tcc agc cgg acc cgg gtg cgg gaa ctc cag ggc caa att gcc      336
 Gly Leu Ser Ser Arg Thr Arg Val Arg Glu Leu Gln Gly Gln Ile Ala
             100                 105                 110

 gcc atc acc ggg atc gcc ccc ggc ggt cag cga atc ctc gtc gga tac      384
 Ala Ile Thr Gly Ile Ala Pro Gly Gly Gln Arg Ile Leu Val Gly Tyr
         115                 120                 125

 cct ccc gag tgc ctg gat ctc agc aat ggg gat acc att ctg gaa gac      432
 Pro Pro Glu Cys Leu Asp Leu Ser Asn Gly Asp Thr Ile Leu Glu Asp
     130                 135                 140

 ttg ccc atc caa tct ggt gac atg ctg atc att gaa gaa gac caa acc      480
 Leu Pro Ile Gln Ser Gly Asp Met Leu Ile Ile Glu Glu Asp Gln Thr
 145                 150                 155                 160

 agg ccc aga agt tca cct gca ttt act aaa cgt ggt gct tct agt tac      528
 Arg Pro Arg Ser Ser Pro Ala Phe Thr Lys Arg Gly Ala Ser Ser Tyr
                 165                 170                 175

 gtc agg gaa act ttg cct gtg ctt acc aga acc gtg gtc cca gca gac      576
 Val Arg Glu Thr Leu Pro Val Leu Thr Arg Thr Val Val Pro Ala Asp
             180                 185                 190

 aac tct tgc ctc ttt act agt gtg tac tat gtc gtc gaa gga gga gtc      624
 Asn Ser Cys Leu Phe Thr Ser Val Tyr Tyr Val Val Glu Gly Gly Val
         195                 200                 205

 ttg aat cca gct tgt gcc cct gag atg aga cgc ctc ata gca caa att      672
 Leu Asn Pro Ala Cys Ala Pro Glu Met Arg Arg Leu Ile Ala Gln Ile
     210                 215                 220

 gta gca agc gat cca gac ttc tat agt gag gca ata ctg gga aaa aca      720
 Val Ala Ser Asp Pro Asp Phe Tyr Ser Glu Ala Ile Leu Gly Lys Thr
 225                 230                 235                 240

 aat caa gag tac tgt gac tgg atc aaa agg gat gac act tgg gga gga      768
 Asn Gln Glu Tyr Cys Asp Trp Ile Lys Arg Asp Asp Thr Trp Gly Gly
                 245                 250                 255

 gca ata gag ata tcg att ttg tcc aag ttt tac caa tgt gaa ata tgt      816
 Ala Ile Glu Ile Ser Ile Leu Ser Lys Phe Tyr Gln Cys Glu Ile Cys
             260                 265                 270

 gta gtg gat aca cac aca gta aga att gat cgt ttt ggg gaa gat gca      864
 Val Val Asp Thr His Thr Val Arg Ile Asp Arg Phe Gly Glu Asp Ala
         275                 280                 285

 gga tat acc aaa agg gtt ctg ctt att tat gat ggc atc cac tat gat      912
 Gly Tyr Thr Lys Arg Val Leu Leu Ile Tyr Asp Gly Ile His Tyr Asp
     290                 295                 300

 cca ctt cag cgt aac ttc cct gat cca gat aca cct cct ctg acc att      960
 Pro Leu Gln Arg Asn Phe Pro Asp Pro Asp Thr Pro Pro Leu Thr Ile
 305                 310                 315                 320

 ttc tcc tct aat gat gat att gtt ctt gta caa gca ctg gaa tta gca     1008
 Phe Ser Ser Asn Asp Asp Ile Val Leu Val Gln Ala Leu Glu Leu Ala
                 325                 330                 335

 gat gaa gct aga aga agg aga cag ttt act gat gtc aac cgc ttc acc     1056
 Asp Glu Ala Arg Arg Arg Arg Gln Phe Thr Asp Val Asn Arg Phe Thr
             340                 345                 350

 ctg aga tgc atg gta tgt cag aaa gga tta act gga caa gca gaa gca     1104
 Leu Arg Cys Met Val Cys Gln Lys Gly Leu Thr Gly Gln Ala Glu Ala
         355                 360                 365

 agg gaa cat gcc aag gag aca ggc cat acc aac ttt gga gaa gtg tga     1152
 Arg Glu His Ala Lys Glu Thr Gly His Thr Asn Phe Gly Glu Val 
     370                 375                 380

 cctatgcatg aatgagggtt gaagcctact acctcacaca tccagaaggc tctgggtttt   1212

 ccaataagct atggtaaccc taaagaacaa aggatacaat gcttgaacca tccttttaac   1272

 ttaaaaccac taagacactg aaattccttg ttaagattaa aattagtgtg caagtttaca   1332

 gatgtgtgtc tacagtggta aactgtacat acatgcctct ttctgctgga gtgacagaat   1392

 aggtgatcct tgccacctac tgacactgac ctgaaggttg agattgagta ttataaacta   1452

 gcacccagca gctttaactt gtagaagaaa gcatcacatt ttgggtaatg tggaaggcct   1512

 cctgtgagtc cactgggcat acgataaaga tagagtatta taaactagca cccagcatgt   1572

 att                                                                 1575




      <210> 259
      <211> 3112
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (110)..(2986)

      <400> 259
 gggtctctgg gtctagtgag ctgcgcggag tgcggcagca acgggccggg ccgggccttc     60

 gggcccgagg cggcggcggc ggtataaagc cggcgactgg gagcatgta    atg tcg     115
                                                          Met Ser
                                                            1

 gaa tgc gga ggc cgc ggc ggc ggc agc agc agc agc gag gac gcc gag      163
 Glu Cys Gly Gly Arg Gly Gly Gly Ser Ser Ser Ser Glu Asp Ala Glu
           5                  10                  15

 gac gag gga ggg ggc ggc ggc ggc ccc gcg ggc tca gac tgc ctc agc      211
 Asp Glu Gly Gly Gly Gly Gly Gly Pro Ala Gly Ser Asp Cys Leu Ser
      20                  25                  30

 tcg agc ccg acc ctg gcc aca gcg tcc tcg gcg ggc cgg ctc cgt cgc      259
 Ser Ser Pro Thr Leu Ala Thr Ala Ser Ser Ala Gly Arg Leu Arg Arg
  35                  40                  45                  50

 ggg ctg cgt ggc gcc ttc ctc atg gcg cgc cag cgg ccg gag ctg ctc      307
 Gly Leu Arg Gly Ala Phe Leu Met Ala Arg Gln Arg Pro Glu Leu Leu
                  55                  60                  65

 tgc ggg gcc gtg gcg ctc ggc tgc gcg ctg ctc ctc gcc ctc aag ttc      355
 Cys Gly Ala Val Ala Leu Gly Cys Ala Leu Leu Leu Ala Leu Lys Phe
              70                  75                  80

 acc tgc agt cga gca aaa gat gtg ata ata cca gca aag cca cct gtc      403
 Thr Cys Ser Arg Ala Lys Asp Val Ile Ile Pro Ala Lys Pro Pro Val
          85                  90                  95

 agc ttt ttc tcc ttg agg tct cca gtc ctt gac ctc ttc cag ggg cag      451
 Ser Phe Phe Ser Leu Arg Ser Pro Val Leu Asp Leu Phe Gln Gly Gln
     100                 105                 110

 ctg gat tat gca gag tac gtt cga cgg gat tca gag gtg gta ctg ctc      499
 Leu Asp Tyr Ala Glu Tyr Val Arg Arg Asp Ser Glu Val Val Leu Leu
 115                 120                 125                 130

 ttc ttc tat gcc cct tgg tgt gga cag tcc atc gct gcc agg gca gaa      547
 Phe Phe Tyr Ala Pro Trp Cys Gly Gln Ser Ile Ala Ala Arg Ala Glu
                 135                 140                 145

 att gag caa gca gca agt cgg ctt tca gat cag gtg ttg ttt gtg gca      595
 Ile Glu Gln Ala Ala Ser Arg Leu Ser Asp Gln Val Leu Phe Val Ala
             150                 155                 160

 att aac tgt tgg tgg aac cag ggg aaa tgc aga aaa cag aaa cac ttc      643
 Ile Asn Cys Trp Trp Asn Gln Gly Lys Cys Arg Lys Gln Lys His Phe
         165                 170                 175

 ttt tat ttt cct gta ata tat ctg tat cat cgg agt ttt gga cca atc      691
 Phe Tyr Phe Pro Val Ile Tyr Leu Tyr His Arg Ser Phe Gly Pro Ile
     180                 185                 190

 gaa tac aaa ggc ccc atg agt gct gtt tac att gag aag ttt gtc cgc      739
 Glu Tyr Lys Gly Pro Met Ser Ala Val Tyr Ile Glu Lys Phe Val Arg
 195                 200                 205                 210

 cgg gtg atg aaa cca ctt ctc tac atc cca tct caa tca gaa tta cta      787
 Arg Val Met Lys Pro Leu Leu Tyr Ile Pro Ser Gln Ser Glu Leu Leu
                 215                 220                 225

 gat ttt ctc tca aac tac gag cct gga gta ctc ggg tac ttt gag ttc      835
 Asp Phe Leu Ser Asn Tyr Glu Pro Gly Val Leu Gly Tyr Phe Glu Phe
             230                 235                 240

 agt ggc tca ccc cag cct cct ggt tat ttg acc ttc ttc acc tca gca      883
 Ser Gly Ser Pro Gln Pro Pro Gly Tyr Leu Thr Phe Phe Thr Ser Ala
         245                 250                 255

 tta cat tca tta aag aaa gat tac cta gga aca gta cga ttt ggg gtt      931
 Leu His Ser Leu Lys Lys Asp Tyr Leu Gly Thr Val Arg Phe Gly Val
     260                 265                 270

 atc aca aat aaa cat ctt gcg aaa ctg gta tcc tta gta cac tct gga      979
 Ile Thr Asn Lys His Leu Ala Lys Leu Val Ser Leu Val His Ser Gly
 275                 280                 285                 290

 agt gtg tat tta cat aga cat ttc aac aca tca ctt gtc ttc ccc agg     1027
 Ser Val Tyr Leu His Arg His Phe Asn Thr Ser Leu Val Phe Pro Arg
                 295                 300                 305

 gag gtc ctg aac tac aca gct gag aac atc tgt aag tgg gcc tta gaa     1075
 Glu Val Leu Asn Tyr Thr Ala Glu Asn Ile Cys Lys Trp Ala Leu Glu
             310                 315                 320

 aac cag gag acg ctc ttt cgg tgg ctg cgg cca cac gga ggc aag agt     1123
 Asn Gln Glu Thr Leu Phe Arg Trp Leu Arg Pro His Gly Gly Lys Ser
         325                 330                 335

 ctc ctg ctg aat aac gag ctg aag aaa gga cca gcg ctg ttt ctg ttc     1171
 Leu Leu Leu Asn Asn Glu Leu Lys Lys Gly Pro Ala Leu Phe Leu Phe
     340                 345                 350

 ata cct ttt aat ccc ctg gcc gaa agt cat cct tta ata gac gag atc     1219
 Ile Pro Phe Asn Pro Leu Ala Glu Ser His Pro Leu Ile Asp Glu Ile
 355                 360                 365                 370

 acc gaa gtg gcc ttg gag tac aac aac tgt cat ggg gac cag gtg gtg     1267
 Thr Glu Val Ala Leu Glu Tyr Asn Asn Cys His Gly Asp Gln Val Val
                 375                 380                 385

 gag cgt ctc ctt cag cac ctg cgg cgg gtg gat gct cca gtg ctg gag     1315
 Glu Arg Leu Leu Gln His Leu Arg Arg Val Asp Ala Pro Val Leu Glu
             390                 395                 400

 tcc ctg gcc ctg gaa gtg ccg gca cag ctg cca gac ccg cca acg atc     1363
 Ser Leu Ala Leu Glu Val Pro Ala Gln Leu Pro Asp Pro Pro Thr Ile
         405                 410                 415

 aca gcg tcc ccc tgc tgc aac act gtg gtg ctg ccc cag tgg cac tcc     1411
 Thr Ala Ser Pro Cys Cys Asn Thr Val Val Leu Pro Gln Trp His Ser
     420                 425                 430

 ttc tcc agg acc cac aac gtc tgt gaa ctc tgt gtc aac cag acc tcc     1459
 Phe Ser Arg Thr His Asn Val Cys Glu Leu Cys Val Asn Gln Thr Ser
 435                 440                 445                 450

 ggg ggc atg aag ccg agc tcg gtc agc gtg cca cag tgc agc ttt ttt     1507
 Gly Gly Met Lys Pro Ser Ser Val Ser Val Pro Gln Cys Ser Phe Phe
                 455                 460                 465

 gaa atg gca gca gct ctg gat tct ttc tac ctc aag gag cag acc ttt     1555
 Glu Met Ala Ala Ala Leu Asp Ser Phe Tyr Leu Lys Glu Gln Thr Phe
             470                 475                 480

 tat cat gtg gca tca gac agc ata gaa tgc agc aat ttt tta act tcc     1603
 Tyr His Val Ala Ser Asp Ser Ile Glu Cys Ser Asn Phe Leu Thr Ser
         485                 490                 495

 tat agc ccc ttc agc tac tac act gca tgt tgc agg acc ata agc agg     1651
 Tyr Ser Pro Phe Ser Tyr Tyr Thr Ala Cys Cys Arg Thr Ile Ser Arg
     500                 505                 510

 ggt gtg tca ggc ttc atc gac tct gaa caa ggt gtc ttt gaa gcc cct     1699
 Gly Val Ser Gly Phe Ile Asp Ser Glu Gln Gly Val Phe Glu Ala Pro
 515                 520                 525                 530

 act gtt gca ttt tct tcc ctt gag aag aaa tgt gag gtt gat gcc cca     1747
 Thr Val Ala Phe Ser Ser Leu Glu Lys Lys Cys Glu Val Asp Ala Pro
                 535                 540                 545

 agc tcc gtt cct cac att gag gag aac agg tat ctc ttt cca gaa gtg     1795
 Ser Ser Val Pro His Ile Glu Glu Asn Arg Tyr Leu Phe Pro Glu Val
             550                 555                 560

 gac atg act agc aca aac ttc aca ggc ctg agc tgc aga acc aac aag     1843
 Asp Met Thr Ser Thr Asn Phe Thr Gly Leu Ser Cys Arg Thr Asn Lys
         565                 570                 575

 act ctc aac atc tac ctt ttg gat tca aat ttg ttt tgg tta tat gca     1891
 Thr Leu Asn Ile Tyr Leu Leu Asp Ser Asn Leu Phe Trp Leu Tyr Ala
     580                 585                 590

 gag aga ctg ggt gct ccg agc tcc act cag gtg aaa gaa ttt gcg gca     1939
 Glu Arg Leu Gly Ala Pro Ser Ser Thr Gln Val Lys Glu Phe Ala Ala
 595                 600                 605                 610

 att gtt gac gtg aaa gaa gaa tct cat tac atc ttg gat cca aag caa     1987
 Ile Val Asp Val Lys Glu Glu Ser His Tyr Ile Leu Asp Pro Lys Gln
                 615                 620                 625

 gca ctg atg aag ctc acc cta gag tct ttt att caa aac ttc agc gtt     2035
 Ala Leu Met Lys Leu Thr Leu Glu Ser Phe Ile Gln Asn Phe Ser Val
             630                 635                 640

 ctc tat agt ccc ttg aaa agg cat ctc att gga agt ggc tct gcc cag     2083
 Leu Tyr Ser Pro Leu Lys Arg His Leu Ile Gly Ser Gly Ser Ala Gln
         645                 650                 655

 ttc ccg tct cag cat tta atc act gaa gtg aca act gat acc ttt tgg     2131
 Phe Pro Ser Gln His Leu Ile Thr Glu Val Thr Thr Asp Thr Phe Trp
     660                 665                 670

 gaa gta gtc ctt caa aaa cag gac gtt ctc ctg ctc tat tac gct ccg     2179
 Glu Val Val Leu Gln Lys Gln Asp Val Leu Leu Leu Tyr Tyr Ala Pro
 675                 680                 685                 690

 tgg tgc ggc ttc tgt cca tcc ctc aat cac atc ttc atc cag cta gct     2227
 Trp Cys Gly Phe Cys Pro Ser Leu Asn His Ile Phe Ile Gln Leu Ala
                 695                 700                 705

 cgg aac ctg ccc atg gac aca ttc act gtg gca agg att gac gtg tct     2275
 Arg Asn Leu Pro Met Asp Thr Phe Thr Val Ala Arg Ile Asp Val Ser
             710                 715                 720

 cag aat gac ctt cct tgg gaa ttt atg gtc gat cgt ctt cct act gtc     2323
 Gln Asn Asp Leu Pro Trp Glu Phe Met Val Asp Arg Leu Pro Thr Val
         725                 730                 735

 ttg ttt ttt ccc tgc aac aga aag gac cta agt gtg aaa tac ccc gaa     2371
 Leu Phe Phe Pro Cys Asn Arg Lys Asp Leu Ser Val Lys Tyr Pro Glu
     740                 745                 750

 gac gtc cct atc acc ctt cca aac ctg ttg agg ttc att ttg cat cac     2419
 Asp Val Pro Ile Thr Leu Pro Asn Leu Leu Arg Phe Ile Leu His His
 755                 760                 765                 770

 tca gac cct gct tcc agc ccc cag aat gtg gct aac tct cct acc aag     2467
 Ser Asp Pro Ala Ser Ser Pro Gln Asn Val Ala Asn Ser Pro Thr Lys
                 775                 780                 785

 gag tgt ctt cag agc gag gca gtc tta cag cgg ggg cac atc tcc cac     2515
 Glu Cys Leu Gln Ser Glu Ala Val Leu Gln Arg Gly His Ile Ser His
             790                 795                 800

 ttg gag aga gag atc cag aaa ctg aga gca gaa ata agc agc ctc cag     2563
 Leu Glu Arg Glu Ile Gln Lys Leu Arg Ala Glu Ile Ser Ser Leu Gln
         805                 810                 815

 cga gca caa gtg cag gtg gag tcc cag ctc tcc agt gcc cgc aga gat     2611
 Arg Ala Gln Val Gln Val Glu Ser Gln Leu Ser Ser Ala Arg Arg Asp
     820                 825                 830

 gag cac cgg ctg cgg cag cag cag cgg gcc ctg gaa gag cag cac agc     2659
 Glu His Arg Leu Arg Gln Gln Gln Arg Ala Leu Glu Glu Gln His Ser
 835                 840                 845                 850

 ctg ctc cac gca cac agt gag cag ctg cag gcc ctc tat gag cag aag     2707
 Leu Leu His Ala His Ser Glu Gln Leu Gln Ala Leu Tyr Glu Gln Lys
                 855                 860                 865

 aca cgt gag ctg cag gag ctg gcc cgc aag ctg cag gag ctg gcc gat     2755
 Thr Arg Glu Leu Gln Glu Leu Ala Arg Lys Leu Gln Glu Leu Ala Asp
             870                 875                 880

 gcc tca gaa aac ctc ctt acc gag aac acg tgg ctc aag atc ctg gtg     2803
 Ala Ser Glu Asn Leu Leu Thr Glu Asn Thr Trp Leu Lys Ile Leu Val
         885                 890                 895

 gcg acc atg gag agg aaa ctg gag ggc agg gat gga gct gaa agc ctg     2851
 Ala Thr Met Glu Arg Lys Leu Glu Gly Arg Asp Gly Ala Glu Ser Leu
     900                 905                 910

 gcg gcc cag aga gag gtc cac ccc aag cag cct gag ccc tca gcc acc     2899
 Ala Ala Gln Arg Glu Val His Pro Lys Gln Pro Glu Pro Ser Ala Thr
 915                 920                 925                 930

 ccc cag ctc cct ggc agc tcc cct cca cct gcc aat gtc agc gcc aca     2947
 Pro Gln Leu Pro Gly Ser Ser Pro Pro Pro Ala Asn Val Ser Ala Thr
                 935                 940                 945

 ctg gtg tct gaa agg aat aag gag aac agg aca gac taa ctttttaaat      2996
 Leu Val Ser Glu Arg Asn Lys Glu Asn Arg Thr Asp 
             950                 955

 gatatgaaga aatcagaggt gaaaattgta cattgggaat atatttatgc aaattttatt   3056

 gaaatttatt gtaaataaag attttctcag tggtctagaa aatcaaaaaa aaaaaa       3112




      <210> 260
      <211> 1771
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(1397)

      <400> 260
 ccgagcgaag gaaggaaggg aggcgcgctg tgcgccccgc ggagcccgcg aaccccgctc     60

 gctgccggct gcccagcctg gctggcacc  atg ctg ccc gcg cgc tgc gcc cgc     113
                                  Met Leu Pro Ala Arg Cys Ala Arg
                                    1               5

 ctg ctc acg ccc cac ttg ctg ctg gtg ttg gtg cag ctg tcc cct gct      161
 Leu Leu Thr Pro His Leu Leu Leu Val Leu Val Gln Leu Ser Pro Ala
      10                  15                  20

 cgc ggc cac cgc acc aca ggc ccc agg ttt cta ata agt gac cgt gac      209
 Arg Gly His Arg Thr Thr Gly Pro Arg Phe Leu Ile Ser Asp Arg Asp
  25                  30                  35                  40

 cca cag tgc aac ctc cac tgc tcc agg act caa ccc aaa ccc atc tgt      257
 Pro Gln Cys Asn Leu His Cys Ser Arg Thr Gln Pro Lys Pro Ile Cys
                  45                  50                  55

 gcc tct gat ggc agg tcc tac gag tcc atg tgt gag tac cag cga gcc      305
 Ala Ser Asp Gly Arg Ser Tyr Glu Ser Met Cys Glu Tyr Gln Arg Ala
              60                  65                  70

 aag tgc cga gac ccg acc ctg ggc gtg gtg cat cga ggt aga tgc aaa      353
 Lys Cys Arg Asp Pro Thr Leu Gly Val Val His Arg Gly Arg Cys Lys
          75                  80                  85

 gat gct ggc cag agc aag tgt cgc ctg gag cgg gct caa gcc ctg gag      401
 Asp Ala Gly Gln Ser Lys Cys Arg Leu Glu Arg Ala Gln Ala Leu Glu
      90                  95                 100

 caa gcc aag aag cct cag gaa gct gtg ttt gtc cca gag tgt ggc gag      449
 Gln Ala Lys Lys Pro Gln Glu Ala Val Phe Val Pro Glu Cys Gly Glu
 105                 110                 115                 120

 gat ggc tcc ttt acc cag gtg cag tgc cat act tac act ggg tac tgc      497
 Asp Gly Ser Phe Thr Gln Val Gln Cys His Thr Tyr Thr Gly Tyr Cys
                 125                 130                 135

 tgg tgt gtc acc ccg gat ggg aag ccc atc agt ggc tct tct gtg cag      545
 Trp Cys Val Thr Pro Asp Gly Lys Pro Ile Ser Gly Ser Ser Val Gln
             140                 145                 150

 aat aaa act cct gta tgt tca ggt tca gtc acc gac aag ccc ttg agc      593
 Asn Lys Thr Pro Val Cys Ser Gly Ser Val Thr Asp Lys Pro Leu Ser
         155                 160                 165

 cag ggt aac tca gga agg aaa gat gac ggg tct aag ccg aca ccc acg      641
 Gln Gly Asn Ser Gly Arg Lys Asp Asp Gly Ser Lys Pro Thr Pro Thr
     170                 175                 180

 atg gag acc cag ccg gtg ttc gat gga gat gaa atc aca gcc cca act      689
 Met Glu Thr Gln Pro Val Phe Asp Gly Asp Glu Ile Thr Ala Pro Thr
 185                 190                 195                 200

 cta tgg att aaa cac ttg gtg atc aag gac tcc aaa ctg aac aac acc      737
 Leu Trp Ile Lys His Leu Val Ile Lys Asp Ser Lys Leu Asn Asn Thr
                 205                 210                 215

 aac ata aga aat tca gag aaa gtc tat tcg tgt gac cag gag agg cag      785
 Asn Ile Arg Asn Ser Glu Lys Val Tyr Ser Cys Asp Gln Glu Arg Gln
             220                 225                 230

 agt gcc ctg gaa gag gcc cag cag aat ccc cgt gag ggt att gtc atc      833
 Ser Ala Leu Glu Glu Ala Gln Gln Asn Pro Arg Glu Gly Ile Val Ile
         235                 240                 245

 cct gaa tgt gcc cct ggg gga ctc tat aag cca gtg caa tgc cac cag      881
 Pro Glu Cys Ala Pro Gly Gly Leu Tyr Lys Pro Val Gln Cys His Gln
     250                 255                 260

 tcc act ggc tac tgc tgg tgt gtg ctg gtg gac aca ggg cgc ccg ctg      929
 Ser Thr Gly Tyr Cys Trp Cys Val Leu Val Asp Thr Gly Arg Pro Leu
 265                 270                 275                 280

 cct ggg acc tcc aca cgc tac gtg atg ccc agt tgt gag agc gac gcc      977
 Pro Gly Thr Ser Thr Arg Tyr Val Met Pro Ser Cys Glu Ser Asp Ala
                 285                 290                 295

 agg gcc aag act aca gag gcg gat gac ccc ttc aag gac agg gag cta     1025
 Arg Ala Lys Thr Thr Glu Ala Asp Asp Pro Phe Lys Asp Arg Glu Leu
             300                 305                 310

 cca ggc tgt cca gaa ggg aag aaa atg gag ttt atc acc agc cta ctg     1073
 Pro Gly Cys Pro Glu Gly Lys Lys Met Glu Phe Ile Thr Ser Leu Leu
         315                 320                 325

 gat gct ctc acc act gac atg gtt cag gcc att aac tca gca gcg ccc     1121
 Asp Ala Leu Thr Thr Asp Met Val Gln Ala Ile Asn Ser Ala Ala Pro
     330                 335                 340

 act gga ggt ggg agg ttc tca gag cca gac ccc agc cac acc ctg gag     1169
 Thr Gly Gly Gly Arg Phe Ser Glu Pro Asp Pro Ser His Thr Leu Glu
 345                 350                 355                 360

 gag cgg gta gtg cac tgg tat ttc agc cag ctg gac agc aat agc agc     1217
 Glu Arg Val Val His Trp Tyr Phe Ser Gln Leu Asp Ser Asn Ser Ser
                 365                 370                 375

 aac gac att aac aag cgg gag atg aag ccc ttc aag cgc tac gtg aag     1265
 Asn Asp Ile Asn Lys Arg Glu Met Lys Pro Phe Lys Arg Tyr Val Lys
             380                 385                 390

 aag aaa gcc aag ccc aag aaa tgt gcc cgg cgt ttc acc gac tac tgt     1313
 Lys Lys Ala Lys Pro Lys Lys Cys Ala Arg Arg Phe Thr Asp Tyr Cys
         395                 400                 405

 gac ctg aac aaa gac aag gtc att tca ctg cct gag ctg aag ggc tgc     1361
 Asp Leu Asn Lys Asp Lys Val Ile Ser Leu Pro Glu Leu Lys Gly Cys
     410                 415                 420

 ctg ggt gtt agc aaa gaa gta gga cgc ctc gtc taa ggag cagaaaaccc     1411
 Leu Gly Val Ser Lys Glu Val Gly Arg Leu Val 
 425                 430                 435

 aagggcaggt ggagagtcca gggaggcagg atggatcccc agacccctac ccttcagcgt   1471

 tgcccatggc cctgccacat cccgtgtaac ataagtggtg ccccccatgt ttgccctttt   1531

 aataactctt acttgcgtgt tttgtttttg gtttcctttt aaacccccaa tttctaatcc   1591

 cccagtggga aaaggaaagg gaagaaagac tttattctct ctctcattgt aagtttttgg   1651

 atctgctact gccaactttt aaagggtttt gggggggtgg gggagggtgt tcttgggcct   1711

 gaaaagaaag agatttatat gctgtatata aataaatatg taaattgtaa aaaaaaaaaa   1771




      <210> 261
      <211> 1402
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (160)..(1386)

      <400> 261
 ggaatccctg tgctgatcgt ggggcatcat atcctgtatg ggaaaatcat ccacctggag     60

 aaaccttttg cagtccttgt caaacacact cctggggatc aggactgtga tgagcttggc    120

 cgcgagactg gcacccggta cctgcgtccc caagaaagt   atg aaa gaa cct cgg     174
                                              Met Lys Glu Pro Arg
                                                1               5

 att ttc cct aga gag cgg cca act cct tgg act cgt gct ccg ctg cca      222
 Ile Phe Pro Arg Glu Arg Pro Thr Pro Trp Thr Arg Ala Pro Leu Pro
                  10                  15                  20

 cct cga gga cgg ctc gac ggt tcc ctg gga cca cag ggg ggt cct gtt      270
 Pro Arg Gly Arg Leu Asp Gly Ser Leu Gly Pro Gln Gly Gly Pro Val
              25                  30                  35

 ctg aac aca ggc cac cca ctg ggt gtg aac tcg gat ccc ttc ctt atg      318
 Leu Asn Thr Gly His Pro Leu Gly Val Asn Ser Asp Pro Phe Leu Met
          40                  45                  50

 gcg gcc ggt tct ctt ggt gga aat ctg acc cca ttt cca agg aac cca      366
 Ala Ala Gly Ser Leu Gly Gly Asn Leu Thr Pro Phe Pro Arg Asn Pro
      55                  60                  65

 tct cct ttt cca gct tca tca ggc tca ttg gct tca aat cca gca cct      414
 Ser Pro Phe Pro Ala Ser Ser Gly Ser Leu Ala Ser Asn Pro Ala Pro
  70                  75                  80                  85

 ttc ccg gct ggt gct cgt gac cca agt atg gct tct ttt cca aga ggg      462
 Phe Pro Ala Gly Ala Arg Asp Pro Ser Met Ala Ser Phe Pro Arg Gly
                  90                  95                 100

 atg aat ccc act ggc aca ggt gca gtt tct ttc cca agg cct ggt ggc      510
 Met Asn Pro Thr Gly Thr Gly Ala Val Ser Phe Pro Arg Pro Gly Gly
             105                 110                 115

 ctc ttg ggg cca ggc cca ggc cca ggc ccc acc cta aac cct agg aca      558
 Leu Leu Gly Pro Gly Pro Gly Pro Gly Pro Thr Leu Asn Pro Arg Thr
         120                 125                 130

 ggg gct ctg cca ggc cca ggg cct ctg tct aac ccc agg tta ggg ggt      606
 Gly Ala Leu Pro Gly Pro Gly Pro Leu Ser Asn Pro Arg Leu Gly Gly
     135                 140                 145

 ctc cca gga cca ggt cct atg tcc aac cca agg gca ggt ggt ctc ctg      654
 Leu Pro Gly Pro Gly Pro Met Ser Asn Pro Arg Ala Gly Gly Leu Leu
 150                 155                 160                 165

 gga gca ggt cct gac ccc aga ggt ggt ggt ccc atg ggc cct gga tct      702
 Gly Ala Gly Pro Asp Pro Arg Gly Gly Gly Pro Met Gly Pro Gly Ser
                 170                 175                 180

 gga cct aac ctg aga gcc ggt gtt ctg tta acc tct ggg aat ggt cct      750
 Gly Pro Asn Leu Arg Ala Gly Val Leu Leu Thr Ser Gly Asn Gly Pro
             185                 190                 195

 ccc aat cct agg cca gtt ggc ctg ggc cca gga cca aac ccc aat ctg      798
 Pro Asn Pro Arg Pro Val Gly Leu Gly Pro Gly Pro Asn Pro Asn Leu
         200                 205                 210

 aga tca ggc ttt tta ggg aca aac cct gcc ccc agg tca ggt gtg ttt      846
 Arg Ser Gly Phe Leu Gly Thr Asn Pro Ala Pro Arg Ser Gly Val Phe
     215                 220                 225

 cca ggc cca ggc ctt ggg ccc aac cca aga cca agt ggc ctg ggc cca      894
 Pro Gly Pro Gly Leu Gly Pro Asn Pro Arg Pro Ser Gly Leu Gly Pro
 230                 235                 240                 245

 ggc cct aat cta gat gcc aga gca ggt ggc ctc ttg ggc aca gga tct      942
 Gly Pro Asn Leu Asp Ala Arg Ala Gly Gly Leu Leu Gly Thr Gly Ser
                 250                 255                 260

 ggt ctt aac tta aga atg gct gga cct caa ggc ctc gat ctt gcc ccc      990
 Gly Leu Asn Leu Arg Met Ala Gly Pro Gln Gly Leu Asp Leu Ala Pro
             265                 270                 275

 att cta aga gca gca ggt ctt tta gga gca aat tca gct tct ttc tca     1038
 Ile Leu Arg Ala Ala Gly Leu Leu Gly Ala Asn Ser Ala Ser Phe Ser
         280                 285                 290

 cag gct tct gga aac atg ggc aca agc cca tcc tcc atg gca aga gta     1086
 Gln Ala Ser Gly Asn Met Gly Thr Ser Pro Ser Ser Met Ala Arg Val
     295                 300                 305

 cct ggc ccc atg ggc cca aac tcg ggt cct agc tct cgg gga att ggc     1134
 Pro Gly Pro Met Gly Pro Asn Ser Gly Pro Ser Ser Arg Gly Ile Gly
 310                 315                 320                 325

 ctt cca ggg cca aat cca tct ccc atg tca agg gct cct ggc ccc ata     1182
 Leu Pro Gly Pro Asn Pro Ser Pro Met Ser Arg Ala Pro Gly Pro Ile
                 330                 335                 340

 ggc cct aat tca gct cat ttc tca agg cca gtt ggc ccc atg ggg gta     1230
 Gly Pro Asn Ser Ala His Phe Ser Arg Pro Val Gly Pro Met Gly Val
             345                 350                 355

 aat gcc aat ccc ttt ccc agg gga gca ggt tca tct gcc ttt tct cag     1278
 Asn Ala Asn Pro Phe Pro Arg Gly Ala Gly Ser Ser Ala Phe Ser Gln
         360                 365                 370

 tct tct ggc aca ttg gca tca aac cca ggt acc ttc caa ggt ccg ctg     1326
 Ser Ser Gly Thr Leu Ala Ser Asn Pro Gly Thr Phe Gln Gly Pro Leu
     375                 380                 385

 gcc tca ggg ctc aaa tcc acc att ttc cca gag gct tgg gcc cct ggc     1374
 Ala Ser Gly Leu Lys Ser Thr Ile Phe Pro Glu Ala Trp Ala Pro Gly
 390                 395                 400                 405

 cca acc cag taa attccagggg ccttgg                                   1402
 Pro Thr Gln 






      <210> 262
      <211> 1728
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (199)..(1224)

      <400> 262
 tttcgtgtgg gagcagggcg agacgggcca ttttcactct gtggtcaaag gaaatgactg     60

 gtctgactcg gtctgggagc ggggcaccca gggtctaagg ataactctgg ggccatgaca    120

 gccatgagtc tcacagagga ccccgagact tctgtgctgc gagtaaccgg acttgttctg    180

 agacctttgc cctagagg  atg gcc aag ggg ctc ctg gtg acc tat gcc ctc     231
                      Met Ala Lys Gly Leu Leu Val Thr Tyr Ala Leu
                        1               5                  10

 tgg gct gtg ggg ggc cct gct ggg ctc cac cac ctg tac ctg gga agg      279
 Trp Ala Val Gly Gly Pro Ala Gly Leu His His Leu Tyr Leu Gly Arg
              15                  20                  25

 gac agc cac gcc ctg ctc tgg atg ctg acc ctg ggg gga ggt ggg ctg      327
 Asp Ser His Ala Leu Leu Trp Met Leu Thr Leu Gly Gly Gly Gly Leu
          30                  35                  40

 ggc tgg ctc tgg gag ttc tgg aag ctc cca agc ttt gta gct cag gcc      375
 Gly Trp Leu Trp Glu Phe Trp Lys Leu Pro Ser Phe Val Ala Gln Ala
      45                  50                  55

 aac aga gcc cag gga cag agg cag agc ccc aga ggg gtg aca ccc cct      423
 Asn Arg Ala Gln Gly Gln Arg Gln Ser Pro Arg Gly Val Thr Pro Pro
  60                  65                  70                  75

 ctg agt ccc att cgc ttt gct gcc cag gtg ata gtt ggc atc tat ttt      471
 Leu Ser Pro Ile Arg Phe Ala Ala Gln Val Ile Val Gly Ile Tyr Phe
                  80                  85                  90

 ggc ctt gtg gca ctg att agc ctt tct tcc atg gtc aac ttc tat att      519
 Gly Leu Val Ala Leu Ile Ser Leu Ser Ser Met Val Asn Phe Tyr Ile
              95                 100                 105

 gtg gcc ctc cca ctg gca gtt ggc tta ggg gtc ttg ctg gtg gct gct      567
 Val Ala Leu Pro Leu Ala Val Gly Leu Gly Val Leu Leu Val Ala Ala
         110                 115                 120

 gtt ggc aac cag acc tca gac ttt aag aac act ctg ggg tca gca ttt      615
 Val Gly Asn Gln Thr Ser Asp Phe Lys Asn Thr Leu Gly Ser Ala Phe
     125                 130                 135

 ctc act tca cct atc ttc tat ggc cgc ccc ata gcc ata ctg ccc att      663
 Leu Thr Ser Pro Ile Phe Tyr Gly Arg Pro Ile Ala Ile Leu Pro Ile
 140                 145                 150                 155

 agc gtg gcc gcc agc att aca gct cag agg cat cgc cgc tac aaa gct      711
 Ser Val Ala Ala Ser Ile Thr Ala Gln Arg His Arg Arg Tyr Lys Ala
                 160                 165                 170

 ttg gtg gca tca gag ccg ctc agt gtg cgg ctc tat cgt ctg ggc ttg      759
 Leu Val Ala Ser Glu Pro Leu Ser Val Arg Leu Tyr Arg Leu Gly Leu
             175                 180                 185

 gct tac ctt gct ttc aca ggc cca ctg gca tac agt gcc ctc tgc aac      807
 Ala Tyr Leu Ala Phe Thr Gly Pro Leu Ala Tyr Ser Ala Leu Cys Asn
         190                 195                 200

 aca gct gcc acc ctc agc tat gtg gca gaa acc ttt ggc tcc ttc ttg      855
 Thr Ala Ala Thr Leu Ser Tyr Val Ala Glu Thr Phe Gly Ser Phe Leu
     205                 210                 215

 aat tgg ttc agc ttc ttc ccc ctt ctt ggc cgc ctc atg gag ttt gtc      903
 Asn Trp Phe Ser Phe Phe Pro Leu Leu Gly Arg Leu Met Glu Phe Val
 220                 225                 230                 235

 ctc ctt ctg cct tac cgg atc tgg agg cta ctg atg ggg gag act ggc      951
 Leu Leu Leu Pro Tyr Arg Ile Trp Arg Leu Leu Met Gly Glu Thr Gly
                 240                 245                 250

 ttc aac agc agc tgc ttt cag gag tgg gcg aag ctc tat gag ttt gtt      999
 Phe Asn Ser Ser Cys Phe Gln Glu Trp Ala Lys Leu Tyr Glu Phe Val
             255                 260                 265

 cac agt ttt cag gat gag aag cgt cag ctg gct tac cag gtt ttg ggc     1047
 His Ser Phe Gln Asp Glu Lys Arg Gln Leu Ala Tyr Gln Val Leu Gly
         270                 275                 280

 ctc tca gaa ggg gca aca aat gaa gaa ata cat cgg agt tac cag gag     1095
 Leu Ser Glu Gly Ala Thr Asn Glu Glu Ile His Arg Ser Tyr Gln Glu
     285                 290                 295

 cta gtg aag gtc tgg cac cca gac cac aac ctg gac cag aca gag gag     1143
 Leu Val Lys Val Trp His Pro Asp His Asn Leu Asp Gln Thr Glu Glu
 300                 305                 310                 315

 gca cag agg cac ttc ctg gag atc cag gct gcg tat gaa gtc ctg agt     1191
 Ala Gln Arg His Phe Leu Glu Ile Gln Ala Ala Tyr Glu Val Leu Ser
                 320                 325                 330

 caa ccc agg aag ccc tgg gga tcc cgg agg tga aaagaaac ttccccctga     1242
 Gln Pro Arg Lys Pro Trp Gly Ser Arg Arg 
             335                 340

 ggactgactc ttcctagcag agctgggcaa cttgtcccaa atctagcttt gcccacgaat   1302

 ggcatcccaa cagagttaaa gaaactgctt gcaggggcat gagctactga ccccagccta   1362

 gatgaccttt aagcttgctt tcaacctgca ttctggagtt attagctttt cagctgaggt   1422

 ttttattaaa tggttttatt tgtcatcttc tgtctgcccc cttgtggaca ttgttttggg   1482

 aagaaaataa aatatttaat tgctcgaaga acaatataat gaccatctca ccctccaaaa   1542

 attcacttgc atcacactgt ttgttttcag ttattcatgt tcacttctag tcgtcgttca   1602

 taaatgtaca tcattttaca tggttgaatc atatcaggga cataattttg tactttcccc   1662

 cctccctgat aaagatgatg tttttacagt aaaataaaaa aatgcttgtg attcaaaaaa   1722

 aaaaaa                                                              1728




      <210> 263
      <211> 3097
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (20)..(3007)

      <400> 263
 gatccacgag ctgcacttc atg gac gag ctg gtc aag gtg gag gcc cat gat      52
                      Met Asp Glu Leu Val Lys Val Glu Ala His Asp
                        1               5                  10

 gct gag gtg ctg tgc ctg gag tac tcc aag cca gag acg ggg ctg acc      100
 Ala Glu Val Leu Cys Leu Glu Tyr Ser Lys Pro Glu Thr Gly Leu Thr
              15                  20                  25

 ttg ctg gcc tca gcc agt cgg gac cgg ctg atc cat gtg ctg aac gtg      148
 Leu Leu Ala Ser Ala Ser Arg Asp Arg Leu Ile His Val Leu Asn Val
          30                  35                  40

 gag aag aac tac aac ctg gag cag acg ctg gat gac cac tcc tcc tcc      196
 Glu Lys Asn Tyr Asn Leu Glu Gln Thr Leu Asp Asp His Ser Ser Ser
      45                  50                  55

 atc acc gcc atc aag ttc gct ggc aac aga gac atc cag atg atc agc      244
 Ile Thr Ala Ile Lys Phe Ala Gly Asn Arg Asp Ile Gln Met Ile Ser
  60                  65                  70                  75

 tgt ggg gct gac aag agc atc tac ttt cgc agt gcc cag cag ggt tcg      292
 Cys Gly Ala Asp Lys Ser Ile Tyr Phe Arg Ser Ala Gln Gln Gly Ser
                  80                  85                  90

 gat gga cta cac ttt gtc cgt acc cac cac gta gca gag aaa acc acc      340
 Asp Gly Leu His Phe Val Arg Thr His His Val Ala Glu Lys Thr Thr
              95                 100                 105

 ttg tat gac atg gac att gac atc acc cag aag tac gtg gcc gtg gcc      388
 Leu Tyr Asp Met Asp Ile Asp Ile Thr Gln Lys Tyr Val Ala Val Ala
         110                 115                 120

 tgc cag gac cgc aat gtg aga gtc tac aac act gtg aac ggg aag cag      436
 Cys Gln Asp Arg Asn Val Arg Val Tyr Asn Thr Val Asn Gly Lys Gln
     125                 130                 135

 gag gcg tgc tac aag ggc tcc cag ggt gac gaa ggg tcc ttg ctg aag      484
 Glu Ala Cys Tyr Lys Gly Ser Gln Gly Asp Glu Gly Ser Leu Leu Lys
 140                 145                 150                 155

 gtc cat gtg gac ccc tca ggc acc ttc ctg gcc acc agc tgc tct gac      532
 Val His Val Asp Pro Ser Gly Thr Phe Leu Ala Thr Ser Cys Ser Asp
                 160                 165                 170

 aaa agc atc tca gtg att gac ttt tac tcg ggc gag tgc att gcc aag      580
 Lys Ser Ile Ser Val Ile Asp Phe Tyr Ser Gly Glu Cys Ile Ala Lys
             175                 180                 185

 atg ttt ggc cat tca gaa att att acc agc atg aag ttc acc tat gac      628
 Met Phe Gly His Ser Glu Ile Ile Thr Ser Met Lys Phe Thr Tyr Asp
         190                 195                 200

 tgt cat cac ttg atc aca gta tct gga gac agc tgc gtg ttc atc tgg      676
 Cys His His Leu Ile Thr Val Ser Gly Asp Ser Cys Val Phe Ile Trp
     205                 210                 215

 cac ctg ggc ccg gag atc acc aac tgc atg aag cag cac ttg ctg gag      724
 His Leu Gly Pro Glu Ile Thr Asn Cys Met Lys Gln His Leu Leu Glu
 220                 225                 230                 235

 att gac cac cgg cag cag cag cag tac aca aat gac aag aag cgg agt      772
 Ile Asp His Arg Gln Gln Gln Gln Tyr Thr Asn Asp Lys Lys Arg Ser
                 240                 245                 250

 ggc cac ccc agg cag gat acg tat gtg tcc aca cct agt gag att cac      820
 Gly His Pro Arg Gln Asp Thr Tyr Val Ser Thr Pro Ser Glu Ile His
             255                 260                 265

 tcc ctg agc cct gga gag caa aca gag gat gat ctg gag gaa gag tgt      868
 Ser Leu Ser Pro Gly Glu Gln Thr Glu Asp Asp Leu Glu Glu Glu Cys
         270                 275                 280

 gag cca gaa gag atg ctg aag aca cca tcc aaa gat agc ttg gat cca      916
 Glu Pro Glu Glu Met Leu Lys Thr Pro Ser Lys Asp Ser Leu Asp Pro
     285                 290                 295

 gat cct cgt tgc ctg cta acc aac ggc aag ctg cca ctg tgg gca aag      964
 Asp Pro Arg Cys Leu Leu Thr Asn Gly Lys Leu Pro Leu Trp Ala Lys
 300                 305                 310                 315

 cgg ctg cta ggg gac gat gat gtg gca gat ggc ttg gcc ttc cac gcc     1012
 Arg Leu Leu Gly Asp Asp Asp Val Ala Asp Gly Leu Ala Phe His Ala
                 320                 325                 330

 aag cgc agc tac cag ccc cac ggc cgc tgg gca gag cgg gcc ggc caa     1060
 Lys Arg Ser Tyr Gln Pro His Gly Arg Trp Ala Glu Arg Ala Gly Gln
             335                 340                 345

 gag ccc ctc aag acc atc ctg gat gcc cag gac ctg gat tgc tac ttt     1108
 Glu Pro Leu Lys Thr Ile Leu Asp Ala Gln Asp Leu Asp Cys Tyr Phe
         350                 355                 360

 acc ccc atg aag ccc gag agt ctg gag aac tcc att ctg gat tca ctg     1156
 Thr Pro Met Lys Pro Glu Ser Leu Glu Asn Ser Ile Leu Asp Ser Leu
     365                 370                 375

 gag cca cag agc ctg gcc agc ctg ctg agt gag tca gag agt ccc cag     1204
 Glu Pro Gln Ser Leu Ala Ser Leu Leu Ser Glu Ser Glu Ser Pro Gln
 380                 385                 390                 395

 gaa gct ggc cgc ggg cac ccc tcc ttc ctg ccc cag cag aag gaa tca     1252
 Glu Ala Gly Arg Gly His Pro Ser Phe Leu Pro Gln Gln Lys Glu Ser
                 400                 405                 410

 tct gag gcc agt gag ctc atc ctc tac tct ctg gag gca gaa gtg aca     1300
 Ser Glu Ala Ser Glu Leu Ile Leu Tyr Ser Leu Glu Ala Glu Val Thr
             415                 420                 425

 gtc aca ggg aca gac agc cag tat tgc agg aag gag gtg gag gcc ggg     1348
 Val Thr Gly Thr Asp Ser Gln Tyr Cys Arg Lys Glu Val Glu Ala Gly
         430                 435                 440

 cct gga gac cag cag ggc gac tcc tac ctc agg gtg tcc tcc gac agc     1396
 Pro Gly Asp Gln Gln Gly Asp Ser Tyr Leu Arg Val Ser Ser Asp Ser
     445                 450                 455

 cca aag gac cag agc ccg cct gag gac tcg ggg gag tca gag gcc gac     1444
 Pro Lys Asp Gln Ser Pro Pro Glu Asp Ser Gly Glu Ser Glu Ala Asp
 460                 465                 470                 475

 ctg gag tgc agc ttc gca gcc atc cac tcc cca gct ccg cct cct gac     1492
 Leu Glu Cys Ser Phe Ala Ala Ile His Ser Pro Ala Pro Pro Pro Asp
                 480                 485                 490

 cct gcc cct cgg ttt gcc acg tcg ctg ccc cat ttc cca gga tgc gca     1540
 Pro Ala Pro Arg Phe Ala Thr Ser Leu Pro His Phe Pro Gly Cys Ala
             495                 500                 505

 ggt ccc aca gaa gat gag ctg tcc ctg ccc gag gga ccc agc gtc ccc     1588
 Gly Pro Thr Glu Asp Glu Leu Ser Leu Pro Glu Gly Pro Ser Val Pro
         510                 515                 520

 agc agc tcc cta ccc cag act ccg gag cag gag aag ttc ctc cgc cac     1636
 Ser Ser Ser Leu Pro Gln Thr Pro Glu Gln Glu Lys Phe Leu Arg His
     525                 530                 535

 cac ttt gag aca ctg act gag tcc ccc tgc aga gct ctg gga gac gtg     1684
 His Phe Glu Thr Leu Thr Glu Ser Pro Cys Arg Ala Leu Gly Asp Val
 540                 545                 550                 555

 gag gcc tct gaa gct gaa gac cac ttc ttc aac cca cgc ctg agt atc     1732
 Glu Ala Ser Glu Ala Glu Asp His Phe Phe Asn Pro Arg Leu Ser Ile
                 560                 565                 570

 tcc acg cag ttc ctc tca agc ctc cag aag gca tcc agg ttc acc cat     1780
 Ser Thr Gln Phe Leu Ser Ser Leu Gln Lys Ala Ser Arg Phe Thr His
             575                 580                 585

 acc ttc cct ccc cgg gca acc cag tgc ctt gtg aag tct cca gag gtc     1828
 Thr Phe Pro Pro Arg Ala Thr Gln Cys Leu Val Lys Ser Pro Glu Val
         590                 595                 600

 aag ctc atg gac cga ggc gga agc cag ccc aga gca ggt act ggc tac     1876
 Lys Leu Met Asp Arg Gly Gly Ser Gln Pro Arg Ala Gly Thr Gly Tyr
     605                 610                 615

 gcc tcc cca gac agg acc cac gtc ctc gct gca ggg aag gct gaa gag     1924
 Ala Ser Pro Asp Arg Thr His Val Leu Ala Ala Gly Lys Ala Glu Glu
 620                 625                 630                 635

 acc ctg gag gcc tgg cgc cca cca cct ccc tgc ctt acg agc ctg gcg     1972
 Thr Leu Glu Ala Trp Arg Pro Pro Pro Pro Cys Leu Thr Ser Leu Ala
                 640                 645                 650

 tcc tgt gtc cct gct tcc tcc gtg ctg ccc aca gac agg aat ctc cca     2020
 Ser Cys Val Pro Ala Ser Ser Val Leu Pro Thr Asp Arg Asn Leu Pro
             655                 660                 665

 acg ccc aca tct gca ccc acc cca ggc ctg gct cag ggt gtc cat gcc     2068
 Thr Pro Thr Ser Ala Pro Thr Pro Gly Leu Ala Gln Gly Val His Ala
         670                 675                 680

 ccc tcc acc tgt tcc tac atg gag gcc act gcc agc tcc cgt gcc agg     2116
 Pro Ser Thr Cys Ser Tyr Met Glu Ala Thr Ala Ser Ser Arg Ala Arg
     685                 690                 695

 ata tca cgc agc atc tcc ctc ggt gac agt gag ggc cct atc gtg gcc     2164
 Ile Ser Arg Ser Ile Ser Leu Gly Asp Ser Glu Gly Pro Ile Val Ala
 700                 705                 710                 715

 aca ctg gcc cag ccc ctc cgt agg cca tcg tcc gtt ggg gag ctg gcc     2212
 Thr Leu Ala Gln Pro Leu Arg Arg Pro Ser Ser Val Gly Glu Leu Ala
                 720                 725                 730

 tcc ttg ggc cag gag ctt cag gcc atc acc acc gcg aca aca ccc agt     2260
 Ser Leu Gly Gln Glu Leu Gln Ala Ile Thr Thr Ala Thr Thr Pro Ser
             735                 740                 745

 ttg gac agt gag ggc caa gag cct gcc ctg cgt tcc tgg ggc aac cac     2308
 Leu Asp Ser Glu Gly Gln Glu Pro Ala Leu Arg Ser Trp Gly Asn His
         750                 755                 760

 gag gcc cgg gcc aac ctg aga ctg acc ctg tca agt gcc tgt gat ggg     2356
 Glu Ala Arg Ala Asn Leu Arg Leu Thr Leu Ser Ser Ala Cys Asp Gly
     765                 770                 775

 ctc ctg cag ccc ccc gtg gat acc cag cct ggc gtc acc gtc cct gca     2404
 Leu Leu Gln Pro Pro Val Asp Thr Gln Pro Gly Val Thr Val Pro Ala
 780                 785                 790                 795

 gtg agc ttc cca gcc cct agc cct gtg gaa gag agc gcc ctg agg ctc     2452
 Val Ser Phe Pro Ala Pro Ser Pro Val Glu Glu Ser Ala Leu Arg Leu
                 800                 805                 810

 cac ggc tct gcc ttt cgc cca agt ctc cca gct cct gag tcc cct ggc     2500
 His Gly Ser Ala Phe Arg Pro Ser Leu Pro Ala Pro Glu Ser Pro Gly
             815                 820                 825

 ctt cct gcc cac ccc agt aac ccc cag ctt cca gag gcc cgg cct ggc     2548
 Leu Pro Ala His Pro Ser Asn Pro Gln Leu Pro Glu Ala Arg Pro Gly
         830                 835                 840

 atc cct ggc ggc act gcc tcc ctc ctg gag ccc acc tcc ggt gca ctt     2596
 Ile Pro Gly Gly Thr Ala Ser Leu Leu Glu Pro Thr Ser Gly Ala Leu
     845                 850                 855

 ggt ctg tta cag ggc agc cct gcc cgc tgg agt gag ccc tgg gtg ccg     2644
 Gly Leu Leu Gln Gly Ser Pro Ala Arg Trp Ser Glu Pro Trp Val Pro
 860                 865                 870                 875

 gtt gaa gcc ctg ccc cca tct ccc ctt gag ctg agc agg gtg ggg aac     2692
 Val Glu Ala Leu Pro Pro Ser Pro Leu Glu Leu Ser Arg Val Gly Asn
                 880                 885                 890

 atc ttg cac agg ctg cag acc acc ttc caa gaa gcc ctc gac ctt tac     2740
 Ile Leu His Arg Leu Gln Thr Thr Phe Gln Glu Ala Leu Asp Leu Tyr
             895                 900                 905

 cgt gtg ttg gtc tcc agt ggc cag gtg gac acc ggg cag cag cag gca     2788
 Arg Val Leu Val Ser Ser Gly Gln Val Asp Thr Gly Gln Gln Gln Ala
         910                 915                 920

 cgg act gag ctg gtc tcc acc ttc ctg tgg atc cac agc cag ctg gag     2836
 Arg Thr Glu Leu Val Ser Thr Phe Leu Trp Ile His Ser Gln Leu Glu
     925                 930                 935

 gct gaa tgc ctg gtg ggg act agt gtg gcc cca gcc cag gct ctg ccc     2884
 Ala Glu Cys Leu Val Gly Thr Ser Val Ala Pro Ala Gln Ala Leu Pro
 940                 945                 950                 955

 agc cca gga ccc ccg tcc cca ccg acg ctg tac ccc ctg gcc agc cca     2932
 Ser Pro Gly Pro Pro Ser Pro Pro Thr Leu Tyr Pro Leu Ala Ser Pro
                 960                 965                 970

 gac ctg cag gcc ctg ctg gaa cac tac tcg gag ctg ctg gtg cag gcc     2980
 Asp Leu Gln Ala Leu Leu Glu His Tyr Ser Glu Leu Leu Val Gln Ala
             975                 980                 985

 gtg cgg agg aag gca cgg ggg cac tga gggcg cagcccctcc accgcagccc     3032
 Val Arg Arg Lys Ala Arg Gly His 
         990                 995

 tgctgcttct gaggacttag gtattttaag cgaataaact gacagctttg aggaaaaaaa   3092

 aaaaa                                                               3097




      <210> 264
      <211> 1525
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(1525)

      <400> 264
 ttttgtctct gtatttttta acactttcaa aattttcgca atcagcatat gctataatca     60

 gaaaaataat catttttgtt acagatttat tatcagagta gatcctttca tataaaggaa    120

 ttttgtcatt cccaaagaaa attccaacat cttgttgcag tatattgctt atggagaaga    180

 gtgagtggta tgtgtcctct ttttcactgc aggttctccc caggatatag cagccgtaag    240

 aagccaagca gccctccaga gc atg cga acg tca cgg ctg atg gca cag aac     292
                          Met Arg Thr Ser Arg Leu Met Ala Gln Asn
                            1               5                  10

 gca ggc atg atg gga ata gga ccc tcc cag aac cct ggg acg atg gcc      340
 Ala Gly Met Met Gly Ile Gly Pro Ser Gln Asn Pro Gly Thr Met Ala
                  15                  20                  25

 acc gca gct gcg cag tcg gag atg gga ctg gcc cct tat agc acc acg      388
 Thr Ala Ala Ala Gln Ser Glu Met Gly Leu Ala Pro Tyr Ser Thr Thr
              30                  35                  40

 cct acc agc caa cca gga atg tac aat atg agc aca ggc atg acc caa      436
 Pro Thr Ser Gln Pro Gly Met Tyr Asn Met Ser Thr Gly Met Thr Gln
          45                  50                  55

 atg ttg cag cat cca aac caa agt ggc atg agc atc aca cat aac caa      484
 Met Leu Gln His Pro Asn Gln Ser Gly Met Ser Ile Thr His Asn Gln
      60                  65                  70

 gcc cag gga ccg agg caa cct gcc tct ggg cag ggg gtt gga atg gtg      532
 Ala Gln Gly Pro Arg Gln Pro Ala Ser Gly Gln Gly Val Gly Met Val
  75                  80                  85                  90

 agt ggc ttt ggt cag agc atg ctg gtg aac tca gcc att acc cag caa      580
 Ser Gly Phe Gly Gln Ser Met Leu Val Asn Ser Ala Ile Thr Gln Gln
                  95                 100                 105

 cat cca cag atg aaa ggg cca gta ggc cag gcc ttg cct agg ccc caa      628
 His Pro Gln Met Lys Gly Pro Val Gly Gln Ala Leu Pro Arg Pro Gln
             110                 115                 120

 gcc cct cca agg ctg cag agc ctt atg gga aca gtc cag caa gga gca      676
 Ala Pro Pro Arg Leu Gln Ser Leu Met Gly Thr Val Gln Gln Gly Ala
         125                 130                 135

 caa agc tgg caa cag agg agc ttg cag ggc atg cct ggg agg act agt      724
 Gln Ser Trp Gln Gln Arg Ser Leu Gln Gly Met Pro Gly Arg Thr Ser
     140                 145                 150

 gga gaa ttg gga cca ttc aac aat ggc gcc agc tac cct ctt caa gct      772
 Gly Glu Leu Gly Pro Phe Asn Asn Gly Ala Ser Tyr Pro Leu Gln Ala
 155                 160                 165                 170

 ggg cag ccg aga ctg acc aag cag cac ttc cca cag gga ctg agc cag      820
 Gly Gln Pro Arg Leu Thr Lys Gln His Phe Pro Gln Gly Leu Ser Gln
                 175                 180                 185

 tca gtc gtg gat gct aac acg ggc aca gtg agg acc ctc aac cca gct      868
 Ser Val Val Asp Ala Asn Thr Gly Thr Val Arg Thr Leu Asn Pro Ala
             190                 195                 200

 gcc atg ggt cgg cag atg atg cca tcg ctc ccg ggg cag caa ggc acc      916
 Ala Met Gly Arg Gln Met Met Pro Ser Leu Pro Gly Gln Gln Gly Thr
         205                 210                 215

 agc cag gcg agg cca atg gtc atg tct ggc ctg agc cag gga gtc cca      964
 Ser Gln Ala Arg Pro Met Val Met Ser Gly Leu Ser Gln Gly Val Pro
     220                 225                 230

 ggc atg cca gcg ttc agc cag ccc cca gca cag cag cag ata ccc agt     1012
 Gly Met Pro Ala Phe Ser Gln Pro Pro Ala Gln Gln Gln Ile Pro Ser
 235                 240                 245                 250

 ggc agc ttt gct cca agc agc cag agc caa gcc tat gag cgg aat gcc     1060
 Gly Ser Phe Ala Pro Ser Ser Gln Ser Gln Ala Tyr Glu Arg Asn Ala
                 255                 260                 265

 cct cag gac gtg tca tac aat tac agt ggc gac gga gct ggg ggt tcc     1108
 Pro Gln Asp Val Ser Tyr Asn Tyr Ser Gly Asp Gly Ala Gly Gly Ser
             270                 275                 280

 ttc cct ggc ctc ccg gac ggt gca gac ctt gtg gac tcc atc atc aaa     1156
 Phe Pro Gly Leu Pro Asp Gly Ala Asp Leu Val Asp Ser Ile Ile Lys
         285                 290                 295

 ggc ggg cca ggg gac gag tgg atg cag gag ctt gat gaa ttg ttt gga     1204
 Gly Gly Pro Gly Asp Glu Trp Met Gln Glu Leu Asp Glu Leu Phe Gly
     300                 305                 310

 att gca aag gct ctg ctg tca caa gga gag cag gct gag ttt gga gca     1252
 Ile Ala Lys Ala Leu Leu Ser Gln Gly Glu Gln Ala Glu Phe Gly Ala
 315                 320                 325                 330

 ggg tcc atc cgg cag tcc tgg gac ggc ttc cct ctg ctg gtg ccc ctg     1300
 Gly Ser Ile Arg Gln Ser Trp Asp Gly Phe Pro Leu Leu Val Pro Leu
                 335                 340                 345

 gtg gca gtc cct cca ggt ggg gct gga gcc tgc tgg cgc cca ata caa     1348
 Val Ala Val Pro Pro Gly Gly Ala Gly Ala Cys Trp Arg Pro Ile Gln
             350                 355                 360

 aac cca tac atc cag gca gat cac tac gga aga gtc gga gcc tgt ggg     1396
 Asn Pro Tyr Ile Gln Ala Asp His Tyr Gly Arg Val Gly Ala Cys Gly
         365                 370                 375

 gtt gga ctg gcc aca ctc agt cct gag aag gcg agt tgc cat gga aag     1444
 Val Gly Leu Ala Thr Leu Ser Pro Glu Lys Ala Ser Cys His Gly Lys
     380                 385                 390

 ctg ggg gca gag gtg ttt ttg gag agg agg cgg cag gca aac att gcc     1492
 Leu Gly Ala Glu Val Phe Leu Glu Arg Arg Arg Gln Ala Asn Ile Ala
 395                 400                 405                 410

 ttt gac ttg ctc tcc gcg tac ccg ggg ttg tag                         1525
 Phe Asp Leu Leu Ser Ala Tyr Pro Gly Leu 
                 415                 420





      <210> 265
      <211> 2106
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (193)..(1764)

      <400> 265
 gcttcccctc acccgctcca cgccctcctg gccgagtgga gttgggtggt gtcgggagcc     60

 tctccctgag gggcaccgcg tcttcaggag ctgggcctcc agtgcggcgc gatgtcaggc    120

 gcggtgacag ctctgtgagt ccgaggccgc ggccgtggcg ctgggcggct gcggggcctg    180

 accggtccgc tc    atg gtg ccg cca cga cgc cat cgc ggg gca gga agg     228
                  Met Val Pro Pro Arg Arg His Arg Gly Ala Gly Arg
                    1               5                  10

 cca ggg gtg ctg agt tct tca cct cct ttt aga ctg aga tct gcc aag      276
 Pro Gly Val Leu Ser Ser Ser Pro Pro Phe Arg Leu Arg Ser Ala Lys
          15                  20                  25

 ttt tcc ggc att gct ctt gag gat ctc aga agg gct ctt aag aca aga      324
 Phe Ser Gly Ile Ala Leu Glu Asp Leu Arg Arg Ala Leu Lys Thr Arg
      30                  35                  40

 ctg caa atg gtg tgt gta ttt gtc atg aac cga atg aat tcc cag aac      372
 Leu Gln Met Val Cys Val Phe Val Met Asn Arg Met Asn Ser Gln Asn
  45                  50                  55                  60

 agt ggt ttc act cag cgc agg cga atg gct ctt ggg att gtt att ctt      420
 Ser Gly Phe Thr Gln Arg Arg Arg Met Ala Leu Gly Ile Val Ile Leu
                  65                  70                  75

 ctg ctt gtt gat gtg ata tgg gtt gct tcc tct gaa ctt act tcg tat      468
 Leu Leu Val Asp Val Ile Trp Val Ala Ser Ser Glu Leu Thr Ser Tyr
              80                  85                  90

 gtt ttt acc cag tac aac aaa cca ttc ttc agc acc ttt gca aaa aca      516
 Val Phe Thr Gln Tyr Asn Lys Pro Phe Phe Ser Thr Phe Ala Lys Thr
          95                 100                 105

 tct atg ttt gtt ttg tac ctt ttg ggc ttt att att tgg aag cca tgg      564
 Ser Met Phe Val Leu Tyr Leu Leu Gly Phe Ile Ile Trp Lys Pro Trp
     110                 115                 120

 aga caa cag tgt aca aga gga ctt cgc gga aag cat gct gct ttt ttt      612
 Arg Gln Gln Cys Thr Arg Gly Leu Arg Gly Lys His Ala Ala Phe Phe
 125                 130                 135                 140

 gca gat gct gaa ggt tac ttt gct gct tgc aca aca gat aca act atg      660
 Ala Asp Ala Glu Gly Tyr Phe Ala Ala Cys Thr Thr Asp Thr Thr Met
                 145                 150                 155

 aat agt tct ttg agt gaa cct ctg tat gtg cct gtg aaa ttc cat gat      708
 Asn Ser Ser Leu Ser Glu Pro Leu Tyr Val Pro Val Lys Phe His Asp
             160                 165                 170

 ctt cca agt gaa aaa cct gag agc aca aac att gat act gaa aaa acc      756
 Leu Pro Ser Glu Lys Pro Glu Ser Thr Asn Ile Asp Thr Glu Lys Thr
         175                 180                 185

 ccc aaa aag tct cgt gtg agg ttc agt aat atc atg gag att cga cag      804
 Pro Lys Lys Ser Arg Val Arg Phe Ser Asn Ile Met Glu Ile Arg Gln
     190                 195                 200

 ctt ccg tca agt cat gca ttg gaa gca aag ttg tct cgc atg tca tat      852
 Leu Pro Ser Ser His Ala Leu Glu Ala Lys Leu Ser Arg Met Ser Tyr
 205                 210                 215                 220

 cct gtg aaa gaa caa gaa tcc ata ctg aaa act gtg ggg aaa ctt act      900
 Pro Val Lys Glu Gln Glu Ser Ile Leu Lys Thr Val Gly Lys Leu Thr
                 225                 230                 235

 gca act caa gta gcg aaa att agc ttt ttt ttt tgc ttt ggg ggg ttt      948
 Ala Thr Gln Val Ala Lys Ile Ser Phe Phe Phe Cys Phe Gly Gly Phe
             240                 245                 250

 ttg gca aat ttg tca tat caa gaa gca ctt tca gac aca caa gtt gct      996
 Leu Ala Asn Leu Ser Tyr Gln Glu Ala Leu Ser Asp Thr Gln Val Ala
         255                 260                 265

 ata gtt aat att tta tct tca act tcc gga ctt ttt acc tta atc ctt     1044
 Ile Val Asn Ile Leu Ser Ser Thr Ser Gly Leu Phe Thr Leu Ile Leu
     270                 275                 280

 gct gca gta ttt cca agt aac agt gga gat aga ttt acc ctt tct aaa     1092
 Ala Ala Val Phe Pro Ser Asn Ser Gly Asp Arg Phe Thr Leu Ser Lys
 285                 290                 295                 300

 cta tta gct gta att tta agc att gga ggc gtt gta ctg gta aac ctg     1140
 Leu Leu Ala Val Ile Leu Ser Ile Gly Gly Val Val Leu Val Asn Leu
                 305                 310                 315

 gca ggg tct gaa aaa cct gct gga aga gac aca gta ggt tcc att tgg     1188
 Ala Gly Ser Glu Lys Pro Ala Gly Arg Asp Thr Val Gly Ser Ile Trp
             320                 325                 330

 tct ctt gct gga gcc atg ctc tat gct gtc tat att gtt atg att aag     1236
 Ser Leu Ala Gly Ala Met Leu Tyr Ala Val Tyr Ile Val Met Ile Lys
         335                 340                 345

 aga aaa gta gat aga gaa gac aag ttg gat att cca atg ttc ttt ggt     1284
 Arg Lys Val Asp Arg Glu Asp Lys Leu Asp Ile Pro Met Phe Phe Gly
     350                 355                 360

 ttt gta ggt ttg ttt aat ctg ctg ctc tta tgg cca ggt ttc ttt tta     1332
 Phe Val Gly Leu Phe Asn Leu Leu Leu Leu Trp Pro Gly Phe Phe Leu
 365                 370                 375                 380

 ctt cat tat act gga ttt gag gac ttc gag ttt ccc aat aaa gta gta     1380
 Leu His Tyr Thr Gly Phe Glu Asp Phe Glu Phe Pro Asn Lys Val Val
                 385                 390                 395

 tta atg tgc att atc att aat ggc ctt att gga aca gta ctc tca gag     1428
 Leu Met Cys Ile Ile Ile Asn Gly Leu Ile Gly Thr Val Leu Ser Glu
             400                 405                 410

 ttc ctg tgg ttg tgg ggc tgc ttt ctt acc tca tca ttg ata ggc aca     1476
 Phe Leu Trp Leu Trp Gly Cys Phe Leu Thr Ser Ser Leu Ile Gly Thr
         415                 420                 425

 ctt gca cta agc ctt aca ata cct ctg tcc ata ata gct gac atg tgt     1524
 Leu Ala Leu Ser Leu Thr Ile Pro Leu Ser Ile Ile Ala Asp Met Cys
     430                 435                 440

 atg caa aag gtg cag ttt tct tgg tta ttt ttt gca gga gct atc cct     1572
 Met Gln Lys Val Gln Phe Ser Trp Leu Phe Phe Ala Gly Ala Ile Pro
 445                 450                 455                 460

 gta ttt ttt tca ttt ttt att gta act ctc cta tgc cat tat aat aat     1620
 Val Phe Phe Ser Phe Phe Ile Val Thr Leu Leu Cys His Tyr Asn Asn
                 465                 470                 475

 tgg gat cct gtg atg gtg gga atc aga aga ata ttt gct ttt ata tgc     1668
 Trp Asp Pro Val Met Val Gly Ile Arg Arg Ile Phe Ala Phe Ile Cys
             480                 485                 490

 aga aaa cat cga att cag aga gtt cca gaa gac agc gaa cag tgt gag     1716
 Arg Lys His Arg Ile Gln Arg Val Pro Glu Asp Ser Glu Gln Cys Glu
         495                 500                 505

 agt ctc att tct atg cac agt gtt tct cag gag gat gga gct agt tag     1764
 Ser Leu Ile Ser Met His Ser Val Ser Gln Glu Asp Gly Ala Ser 
     510                 515                 520

 ctgtctgttg tctgtagccc agcttgataa tggaactata cagcgaagag acaatctctg   1824

 gcaagttttt gtagaaaaaa tgtttcagtg cctagtctga aaaataacag tttgagttct   1884

 ttgaaactct aaaatatatt tttctcatac ctgttttctt cattttcata atgaagcact   1944

 ttgctatgta gctgtgtaca tatcactaca gttataggaa gtttcagtct acagtccatc   2004

 caaaggacca acctgcctta cacatctcaa ggaattcagc tgttgaaatc atttgaacta   2064

 atcaaggaat aaatcctaat gttctgggaa aaaaaaaaaa aa                      2106




      <210> 266
      <211> 959
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (174)..(557)

      <400> 266
 tgcttttgtc ttcttcacaa accttgctga ccagtatcag agttgaattt aggacctatt     60

 tcagggaact ggaaaaggag gaggtgagta ttgattttca tgggaaccct gaggagcagc    120

 atctgacggc caagggccac tgggaaggag gccttccagg aggagatgca cta   atg     176
                                                              Met
                                                                1

 gcc cct gca gag aag ggt ggg aag aag aag ggc tct cct gct gtc aat      224
 Ala Pro Ala Glu Lys Gly Gly Lys Lys Lys Gly Ser Pro Ala Val Asn
               5                  10                  15

 gag gtg gtg aca caa gaa tac acc atc aac att cac aag cac atc cat      272
 Glu Val Val Thr Gln Glu Tyr Thr Ile Asn Ile His Lys His Ile His
          20                  25                  30

 gga gtg ggc ttc aag aag cgt gca cct cgg gca ctc aga gag att cgg      320
 Gly Val Gly Phe Lys Lys Arg Ala Pro Arg Ala Leu Arg Glu Ile Arg
      35                  40                  45

 aaa ttt gcc atg aag gag atg gga act cca gat gtg cgc att gac acc      368
 Lys Phe Ala Met Lys Glu Met Gly Thr Pro Asp Val Arg Ile Asp Thr
  50                  55                  60                  65

 agg ctc aac aaa gct gtc tgg gcc aaa gga ata agg aat gtg cca tac      416
 Arg Leu Asn Lys Ala Val Trp Ala Lys Gly Ile Arg Asn Val Pro Tyr
                  70                  75                  80

 cga atc cgt gtg cgg ctg tcc aga aaa cgt aat gag gat gaa gat tca      464
 Arg Ile Arg Val Arg Leu Ser Arg Lys Arg Asn Glu Asp Glu Asp Ser
              85                  90                  95

 cca cat aag cta tat act ttg gtt acc tat gta cct gtt acc act ttc      512
 Pro His Lys Leu Tyr Thr Leu Val Thr Tyr Val Pro Val Thr Thr Phe
         100                 105                 110

 aaa att tct gtg cta aac agt gtt aca gtc gcc aag agc cca taa atg      560
 Lys Ile Ser Val Leu Asn Ser Val Thr Val Ala Lys Ser Pro 
     115                 120                 125

 gagccctcct ggaagtggat gaggccttgt gtctcggctc ttcattgctt cctgagctgc    620

 agcagatgcc tttacaacca agctcaccga ggacgtctgt ctcccatatt acactggcag    680

 agggccaggc ctgttctaca cggccggggt ttcaacaagg tactgatgtc ttctgccctt    740

 gcctcttcga caggcaagta ataagactta agtgaagaga attctttagg cacacaaatt    800

 cacatttgat gtaatctcat tatacttcct gatctgtgat tgaaaacttt catttcgtaa    860

 ctagtatgtc tgtcccacct ttaaaaagtt tttcattatg aaagtaagta tttgttagaa    920

 ttaagtctat ttaaatgaaa aataaaaaaa aaaagatct                           959




      <210> 267
      <211> 401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (45)..(347)

      <400> 267
 aggactgaga ctctggttag ggcgccctcc ccactggtac caac atg aag ctg gtt      56
                                                  Met Lys Leu Val
                                                    1

 tca gca acg gtg gta ctc ctc acc atc tgc agc ctt gaa gga gct ttg      104
 Ser Ala Thr Val Val Leu Leu Thr Ile Cys Ser Leu Glu Gly Ala Leu
   5                  10                  15                  20

 gtt cgg ata cag gca aag gag cca tgt gtg gag agc ctg gtt tct cag      152
 Val Arg Ile Gln Ala Lys Glu Pro Cys Val Glu Ser Leu Val Ser Gln
                  25                  30                  35

 tac ttc caa acc gtg act gac tat ggc aag gac ctg atg gaa aag gtc      200
 Tyr Phe Gln Thr Val Thr Asp Tyr Gly Lys Asp Leu Met Glu Lys Val
              40                  45                  50

 aag agc cca gag ctt cag gcc gag gcc aag tct tac ttt gaa aag tca      248
 Lys Ser Pro Glu Leu Gln Ala Glu Ala Lys Ser Tyr Phe Glu Lys Ser
          55                  60                  65

 aag gag cag ctg aca ccc ctg atc aag aag gct gga acg gaa ctg gtt      296
 Lys Glu Gln Leu Thr Pro Leu Ile Lys Lys Ala Gly Thr Glu Leu Val
      70                  75                  80

 aac ttc ttg agc tat ttc gtg gaa ctt gga aca cag cct gcc acc cag      344
 Asn Phe Leu Ser Tyr Phe Val Glu Leu Gly Thr Gln Pro Ala Thr Gln
  85                  90                  95                 100

 tga agtg tccagaccat tgtcttccaa ccccagctgg cctctagaac acccactggc      401
 






      <210> 268
      <211> 2585
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (474)..(2453)

      <400> 268
 ggcatctggg ctgagatgca aaggaagaat gggaattagg tgaaaaaatc agaggcgagg     60

 ggtagcatta caggggaggg gatagctagt gcagaggccc ggaggtaaag tgccagactc    120

 agctctttgg agcaaccgaa cagtttctag aggctgggtg cagctctcca ttggattaga    180

 ggttcacagg ggaggctggc caagcatgta gtcacatcag ggaggagaag gaggagccaa    240

 ggaagtgact ggagaggcag gttggggtca gattgcaggc ctttgatgtc ctgtgaaggc    300

 tgttagatcc tggtggtgtg gcctgctgtg ggctcacatg tcttcttggg ctggcagacc    360

 tttccatccg gggtttcacc attcttcctt tcccccatgc tgtgcctctc ggaccccaag    420

 ggacctcaga acagcatgtc cggattcgag tcatcaagaa gaaaaaggtc att   atg     476
                                                              Met
                                                                1

 aag aag cgg aag aag cta act cta act cgc ccc acc cca ctg gtg act      524
 Lys Lys Arg Lys Lys Leu Thr Leu Thr Arg Pro Thr Pro Leu Val Thr
               5                  10                  15

 gcc ggg ccc ctt gtg acc ccc act cca gca ggg acc ctc gac ccc gct      572
 Ala Gly Pro Leu Val Thr Pro Thr Pro Ala Gly Thr Leu Asp Pro Ala
          20                  25                  30

 gag aaa caa gaa aca ggc tgt cct cct ttg ggt ctg gag tcc ctg cga      620
 Glu Lys Gln Glu Thr Gly Cys Pro Pro Leu Gly Leu Glu Ser Leu Arg
      35                  40                  45

 gtt tca gat agc cgg ctt gag gca tcc agc agc cag tcc ttt ggt ctt      668
 Val Ser Asp Ser Arg Leu Glu Ala Ser Ser Ser Gln Ser Phe Gly Leu
  50                  55                  60                  65

 gga cca cac cga gga cgg ctc aac att cag tca ggc ctg gag gac ggc      716
 Gly Pro His Arg Gly Arg Leu Asn Ile Gln Ser Gly Leu Glu Asp Gly
                  70                  75                  80

 gat cta tat gat gga gcc tgg tgt gct gag gag cag gac gcc gat cca      764
 Asp Leu Tyr Asp Gly Ala Trp Cys Ala Glu Glu Gln Asp Ala Asp Pro
              85                  90                  95

 tgg ttt cag gtg gac gct ggg cac ccc acc cgc ttc tcg ggt gtt atc      812
 Trp Phe Gln Val Asp Ala Gly His Pro Thr Arg Phe Ser Gly Val Ile
         100                 105                 110

 aca cag ggc agg aac tct gtc tgg agg tat gac tgg gtc aca tca tac      860
 Thr Gln Gly Arg Asn Ser Val Trp Arg Tyr Asp Trp Val Thr Ser Tyr
     115                 120                 125

 aag gtc cag ttc agc aat gac agt cgg acc tgg tgg gga agt agg aac      908
 Lys Val Gln Phe Ser Asn Asp Ser Arg Thr Trp Trp Gly Ser Arg Asn
 130                 135                 140                 145

 cac agc agt ggg atg gac gca gta ttt cct gcc aat tca gac cca gaa      956
 His Ser Ser Gly Met Asp Ala Val Phe Pro Ala Asn Ser Asp Pro Glu
                 150                 155                 160

 act cca gtg ctg aac ctc ctg ccg gag ccc cag gtg gcc cgc ttc att     1004
 Thr Pro Val Leu Asn Leu Leu Pro Glu Pro Gln Val Ala Arg Phe Ile
             165                 170                 175

 cgc ctg ctg ccc cag acc tgg ctc cag gga ggc gcg cct tgc ctc cgg     1052
 Arg Leu Leu Pro Gln Thr Trp Leu Gln Gly Gly Ala Pro Cys Leu Arg
         180                 185                 190

 gca gag atc ctg gcc tgc cca gtc tca gac ccc aat gac cta ttc ctt     1100
 Ala Glu Ile Leu Ala Cys Pro Val Ser Asp Pro Asn Asp Leu Phe Leu
     195                 200                 205

 gag gcc cct gcg tcg gga tcc tct gac cct cta gac ttt cag cat cac     1148
 Glu Ala Pro Ala Ser Gly Ser Ser Asp Pro Leu Asp Phe Gln His His
 210                 215                 220                 225

 aat tac aag gcc atg agg aag ctg atg aag cag gta caa gag caa tgc     1196
 Asn Tyr Lys Ala Met Arg Lys Leu Met Lys Gln Val Gln Glu Gln Cys
                 230                 235                 240

 ccc aac atc acc cgc atc tac agc att ggg aag agc tac cag ggc ctg     1244
 Pro Asn Ile Thr Arg Ile Tyr Ser Ile Gly Lys Ser Tyr Gln Gly Leu
             245                 250                 255

 aag ctg tat gtg atg gaa atg tcg gac aag cct ggg gag cat gag ctg     1292
 Lys Leu Tyr Val Met Glu Met Ser Asp Lys Pro Gly Glu His Glu Leu
         260                 265                 270

 ggg gag cct gag gtg cgc tac gtg gct ggc atg cat ggg aac gag gcc     1340
 Gly Glu Pro Glu Val Arg Tyr Val Ala Gly Met His Gly Asn Glu Ala
     275                 280                 285

 ctg ggg cgg gag ttg ctt ctg ctc ctg atg cag ttc ctg tgc cat gag     1388
 Leu Gly Arg Glu Leu Leu Leu Leu Leu Met Gln Phe Leu Cys His Glu
 290                 295                 300                 305

 ttc ctg cga ggg aac cca cgg gtg acc cgg ctg ctc tct gag atg cgc     1436
 Phe Leu Arg Gly Asn Pro Arg Val Thr Arg Leu Leu Ser Glu Met Arg
                 310                 315                 320

 att cac ctg ctg ccc tcc atg aac cct gat ggc tat gag atc gcc tac     1484
 Ile His Leu Leu Pro Ser Met Asn Pro Asp Gly Tyr Glu Ile Ala Tyr
             325                 330                 335

 cac cgg ggt tca gag ctg gtg ggc tgg gcc gag ggc cgc tgg aac aac     1532
 His Arg Gly Ser Glu Leu Val Gly Trp Ala Glu Gly Arg Trp Asn Asn
         340                 345                 350

 cag agc atc gat ctt aac cat aat ttt gct gac ctc aac aca cca ctg     1580
 Gln Ser Ile Asp Leu Asn His Asn Phe Ala Asp Leu Asn Thr Pro Leu
     355                 360                 365

 tgg gaa gca cag gac gat ggg aag gtg ccc cac atc gtc ccc aac cat     1628
 Trp Glu Ala Gln Asp Asp Gly Lys Val Pro His Ile Val Pro Asn His
 370                 375                 380                 385

 cac ctg cca ttg ccc act tac tac acc ctg ccc aat gcc acc gtg gct     1676
 His Leu Pro Leu Pro Thr Tyr Tyr Thr Leu Pro Asn Ala Thr Val Ala
                 390                 395                 400

 cct gaa acg cgg gca gta atc aag tgg atg aag cgg atc ccc ttt gtg     1724
 Pro Glu Thr Arg Ala Val Ile Lys Trp Met Lys Arg Ile Pro Phe Val
             405                 410                 415

 cta agt gcc aac ctc cac ggg ggt gag ctc gtg gtg tcc tac cca ttc     1772
 Leu Ser Ala Asn Leu His Gly Gly Glu Leu Val Val Ser Tyr Pro Phe
         420                 425                 430

 gac atg act cgc acc ccg tgg gct gcc cgc gag ctc acg ccc aca cca     1820
 Asp Met Thr Arg Thr Pro Trp Ala Ala Arg Glu Leu Thr Pro Thr Pro
     435                 440                 445

 gat gat gct gtg ttt cgc tgg ctc agc act gtc tat gct ggc agt aat     1868
 Asp Asp Ala Val Phe Arg Trp Leu Ser Thr Val Tyr Ala Gly Ser Asn
 450                 455                 460                 465

 ctg gcc atg cag gac acc agc cgc cga ccc tgc cac agc cag gac ttc     1916
 Leu Ala Met Gln Asp Thr Ser Arg Arg Pro Cys His Ser Gln Asp Phe
                 470                 475                 480

 tcc gtg cac ggc aac atc atc aac ggg gct gac tgg cac acg gtc ccc     1964
 Ser Val His Gly Asn Ile Ile Asn Gly Ala Asp Trp His Thr Val Pro
             485                 490                 495

 ggg agc atg aat gac ttc agc tac cta cac acc aac tgc ttt gag gtc     2012
 Gly Ser Met Asn Asp Phe Ser Tyr Leu His Thr Asn Cys Phe Glu Val
         500                 505                 510

 act gtg gag ctg tcc tgt gac aag ttc cct cac gag aat gaa ttg ccc     2060
 Thr Val Glu Leu Ser Cys Asp Lys Phe Pro His Glu Asn Glu Leu Pro
     515                 520                 525

 cag gag tgg gag aac aac aaa gac gcc ctc ctc acc tac ctg gag cag     2108
 Gln Glu Trp Glu Asn Asn Lys Asp Ala Leu Leu Thr Tyr Leu Glu Gln
 530                 535                 540                 545

 gtg cgc atg ggc att gca gga gtg gtg agg gac aag gac acg gag ctt     2156
 Val Arg Met Gly Ile Ala Gly Val Val Arg Asp Lys Asp Thr Glu Leu
                 550                 555                 560

 ggg att gct gac gct gtc att gcc gtg gat ggg att aac cat gac gtg     2204
 Gly Ile Ala Asp Ala Val Ile Ala Val Asp Gly Ile Asn His Asp Val
             565                 570                 575

 acc acg gcg tgg ggc ggg gat tat tgg cgt ctg ctg acc cca ggg gac     2252
 Thr Thr Ala Trp Gly Gly Asp Tyr Trp Arg Leu Leu Thr Pro Gly Asp
         580                 585                 590

 tac atg gtg act gcc agt gcc gag ggc tac cat tca gtg aca cgg aac     2300
 Tyr Met Val Thr Ala Ser Ala Glu Gly Tyr His Ser Val Thr Arg Asn
     595                 600                 605

 tgt cgg gtc acc ttt gaa gag ggc ccc ttc ccc tgc aat ttc gtg ctc     2348
 Cys Arg Val Thr Phe Glu Glu Gly Pro Phe Pro Cys Asn Phe Val Leu
 610                 615                 620                 625

 acc aag act ccc aaa cag agg ctg cgc gag ctg ctg gca gct ggg gcc     2396
 Thr Lys Thr Pro Lys Gln Arg Leu Arg Glu Leu Leu Ala Ala Gly Ala
                 630                 635                 640

 aag gtg ccc ccg gac ctt cgc agg cgc ctg gag cgg cta agg gga cag     2444
 Lys Val Pro Pro Asp Leu Arg Arg Arg Leu Glu Arg Leu Arg Gly Gln
             645                 650                 655

 aag gat tga tacctgc ggtttaagag ccctagggca ggctggacct gtcaagacgg     2500
 Lys Asp 


 gaaggggaag agtagagagg gagggacaaa gtgaggaaaa ggtgctcatt aaagctaccg   2560

 ggcaccttag ctcaaaaaaa aaaaa                                         2585




      <210> 269
      <211> 1883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(1829)

      <400> 269
 cctgaaccct gaggaggaag aaagatagaa gataagagtt aattggcgct aggctttgtt     60

 gtaggaagtt tgtaagtttt aaaatagcaa gtagattcac gtagaccttg tcaggaaatt    120

 ggtcactatc catctaggcc ctagaagtga gaggaggaat cttgcgaact cattttctag    180

 ttgctttgta ttcaaatctt agttgttaat tatcttgttc tagtaatcac ctaaaatatt    240

 agacacttaa a atg ttg ggg aaa cgt aag cgt gtg gtg ttg aca att aag     290
              Met Leu Gly Lys Arg Lys Arg Val Val Leu Thr Ile Lys
                1               5                  10

 gac aag ctt gac att att aag aaa ctt gag gaa ggc atc tct ttc aaa      338
 Asp Lys Leu Asp Ile Ile Lys Lys Leu Glu Glu Gly Ile Ser Phe Lys
      15                  20                  25

 aaa ctt tcc gtg gtg tac gga att ggt gaa tcc aca gtt cgt gat att      386
 Lys Leu Ser Val Val Tyr Gly Ile Gly Glu Ser Thr Val Arg Asp Ile
  30                  35                  40                  45

 aaa aag aac aaa gaa agg att ata aac tat gca aac agt tca gat cct      434
 Lys Lys Asn Lys Glu Arg Ile Ile Asn Tyr Ala Asn Ser Ser Asp Pro
                  50                  55                  60

 acc agt gga gta tcc aaa cgt aaa tct atg aag tca tca aca tac gag      482
 Thr Ser Gly Val Ser Lys Arg Lys Ser Met Lys Ser Ser Thr Tyr Glu
              65                  70                  75

 gag ctt gat aga gtt atg ata gag tgg ttt aac caa cag aaa aca gat      530
 Glu Leu Asp Arg Val Met Ile Glu Trp Phe Asn Gln Gln Lys Thr Asp
          80                  85                  90

 ggg att cca gtg tcc gga acg att tgt gca aaa caa gcc aag ttc ttt      578
 Gly Ile Pro Val Ser Gly Thr Ile Cys Ala Lys Gln Ala Lys Phe Phe
      95                 100                 105

 ttt gat gct ttg gga atg gaa ggt gat ttt aat gca tcg tca ggc tgg      626
 Phe Asp Ala Leu Gly Met Glu Gly Asp Phe Asn Ala Ser Ser Gly Trp
 110                 115                 120                 125

 cta act cga ttt aag cag cgc cat ggt att cca aag gct gct ggt aaa      674
 Leu Thr Arg Phe Lys Gln Arg His Gly Ile Pro Lys Ala Ala Gly Lys
                 130                 135                 140

 gga aca aaa tta aaa gga gat gaa act gct gcc aga gaa ttt tgt ggt      722
 Gly Thr Lys Leu Lys Gly Asp Glu Thr Ala Ala Arg Glu Phe Cys Gly
             145                 150                 155

 agc ttt cag gaa ttt gtt gaa aaa gag aat cta caa cca gag caa att      770
 Ser Phe Gln Glu Phe Val Glu Lys Glu Asn Leu Gln Pro Glu Gln Ile
         160                 165                 170

 tat ggt gct gat caa act gga ttg ttt tgg aaa tgt cta cca tca agg      818
 Tyr Gly Ala Asp Gln Thr Gly Leu Phe Trp Lys Cys Leu Pro Ser Arg
     175                 180                 185

 aca tta act ctt gaa act gac caa agt act tct ggg tgt agg tca agc      866
 Thr Leu Thr Leu Glu Thr Asp Gln Ser Thr Ser Gly Cys Arg Ser Ser
 190                 195                 200                 205

 aga gag aga atc atc att atg tgt tgc gca aat gcc aca ggt tta cac      914
 Arg Glu Arg Ile Ile Ile Met Cys Cys Ala Asn Ala Thr Gly Leu His
                 210                 215                 220

 aaa ctt aat ctt tgt gtt gtg ggg aag gcc aaa aag ccc cga gca ttc      962
 Lys Leu Asn Leu Cys Val Val Gly Lys Ala Lys Lys Pro Arg Ala Phe
             225                 230                 235

 aaa ggc act gac ctt tca aac ctt cct gtg aca tat tac agt caa aaa     1010
 Lys Gly Thr Asp Leu Ser Asn Leu Pro Val Thr Tyr Tyr Ser Gln Lys
         240                 245                 250

 ggt gca tgg ata gaa cag tct gtt ttc aga cag tgg ttt gaa aag tac     1058
 Gly Ala Trp Ile Glu Gln Ser Val Phe Arg Gln Trp Phe Glu Lys Tyr
     255                 260                 265

 ttt gtg cca cag gta cag aag cat ttg aaa tcc aag gga ctt tta gaa     1106
 Phe Val Pro Gln Val Gln Lys His Leu Lys Ser Lys Gly Leu Leu Glu
 270                 275                 280                 285

 aaa gca gtg ctt ctt tta gat ttc ccc cca gca cgt cca aat gaa gaa     1154
 Lys Ala Val Leu Leu Leu Asp Phe Pro Pro Ala Arg Pro Asn Glu Glu
                 290                 295                 300

 atg ttg agt tca gat gat ggc aga ata att gtg aag tat ttg cca cca     1202
 Met Leu Ser Ser Asp Asp Gly Arg Ile Ile Val Lys Tyr Leu Pro Pro
             305                 310                 315

 aat gtc aca agt ctg att caa cca atg agc cag gga gtt cta gcc act     1250
 Asn Val Thr Ser Leu Ile Gln Pro Met Ser Gln Gly Val Leu Ala Thr
         320                 325                 330

 gta aaa aga tac tat cga gca gga ctt ctc cag aaa tac atg gat gaa     1298
 Val Lys Arg Tyr Tyr Arg Ala Gly Leu Leu Gln Lys Tyr Met Asp Glu
     335                 340                 345

 gga aat gac cca aaa ata ttt tgg aag aac ttg aca gtg ttg gat gca     1346
 Gly Asn Asp Pro Lys Ile Phe Trp Lys Asn Leu Thr Val Leu Asp Ala
 350                 355                 360                 365

 att tat gaa gtg tca aga gct tgg aac atg gta aaa tca agt acc ata     1394
 Ile Tyr Glu Val Ser Arg Ala Trp Asn Met Val Lys Ser Ser Thr Ile
                 370                 375                 380

 acc aaa gca tgg aaa aaa ctt ttc cct ggc aat gaa gag aat tca ggt     1442
 Thr Lys Ala Trp Lys Lys Leu Phe Pro Gly Asn Glu Glu Asn Ser Gly
             385                 390                 395

 atg aac att gat gaa gga gcc att tta gca gct aat tta gca aca gtt     1490
 Met Asn Ile Asp Glu Gly Ala Ile Leu Ala Ala Asn Leu Ala Thr Val
         400                 405                 410

 tta cag aac aca gaa gaa tgt gaa cat gtt gac att gag aat att gat     1538
 Leu Gln Asn Thr Glu Glu Cys Glu His Val Asp Ile Glu Asn Ile Asp
     415                 420                 425

 cag tgg ttc gac tct cgg agc agt gac tca agc tgt cag gtg ctg act     1586
 Gln Trp Phe Asp Ser Arg Ser Ser Asp Ser Ser Cys Gln Val Leu Thr
 430                 435                 440                 445

 gac agt gaa agt gct gag gac cag acc aag gct gct gag caa aag cct     1634
 Asp Ser Glu Ser Ala Glu Asp Gln Thr Lys Ala Ala Glu Gln Lys Pro
                 450                 455                 460

 tcc agt aag agt aga aaa aca gaa ctg aat cca gag aag cat att agc     1682
 Ser Ser Lys Ser Arg Lys Thr Glu Leu Asn Pro Glu Lys His Ile Ser
             465                 470                 475

 cat aaa gcg gca ctt gaa tgg act gaa aat tta ctg gat tat ctt gaa     1730
 His Lys Ala Ala Leu Glu Trp Thr Glu Asn Leu Leu Asp Tyr Leu Glu
         480                 485                 490

 caa caa gat gac atg ctt ctg tct gat aaa ttg gta tta agg agg ctt     1778
 Gln Gln Asp Asp Met Leu Leu Ser Asp Lys Leu Val Leu Arg Arg Leu
     495                 500                 505

 cgg acc ata ata aga aaa aaa cag aag atc caa aat aac aaa aat cat     1826
 Arg Thr Ile Ile Arg Lys Lys Gln Lys Ile Gln Asn Asn Lys Asn His
 510                 515                 520                 525

 taa taag gctcttaagt atttcagtgt atctgcatct ttgtgactat ctgcagtgaa     1883
 






      <210> 270
      <211> 2375
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (116)..(1660)

      <400> 270
 tttcgtccgg tccctccctt cccgccgaca ccgcgaagtg cgccctgggc ggcggcggcc     60

 ggtgagcgtc ccgcgctgga gccctcagag gcgggcccgt cagatttttt aaaaa atg     118
                                                              Met
                                                                1

 gat ttg gcc aac cat gga ctt att cta ctg caa cag tta aac gct cag      166
 Asp Leu Ala Asn His Gly Leu Ile Leu Leu Gln Gln Leu Asn Ala Gln
               5                  10                  15

 cga gag ttt ggt ttc ctg tgt gac tgc acg gtt gca atc ggc gat gta      214
 Arg Glu Phe Gly Phe Leu Cys Asp Cys Thr Val Ala Ile Gly Asp Val
          20                  25                  30

 tac ttc aag gca cac aaa tca gtt ctt gct tca ttc tcc aat tac ttt      262
 Tyr Phe Lys Ala His Lys Ser Val Leu Ala Ser Phe Ser Asn Tyr Phe
      35                  40                  45

 aag atg ttg ttt gtc cat cag acc agt gag tgt gtc cgc ttg aaa cca      310
 Lys Met Leu Phe Val His Gln Thr Ser Glu Cys Val Arg Leu Lys Pro
  50                  55                  60                  65

 act gac ata cag ccc gac atc ttc agc tat ctc tta cac ttg atg tac      358
 Thr Asp Ile Gln Pro Asp Ile Phe Ser Tyr Leu Leu His Leu Met Tyr
                  70                  75                  80

 act ggg aag atg gcg cct cag ctc atc gac ccg gtt cga tta gaa cag      406
 Thr Gly Lys Met Ala Pro Gln Leu Ile Asp Pro Val Arg Leu Glu Gln
              85                  90                  95

 ggc atc aag ttt ctg cac gcc tac ccg ctc att cag gaa gcc agc ctc      454
 Gly Ile Lys Phe Leu His Ala Tyr Pro Leu Ile Gln Glu Ala Ser Leu
         100                 105                 110

 gcc agc cag gga gcc ttt tct cac cct gac caa gtt ttc cca ctg gct      502
 Ala Ser Gln Gly Ala Phe Ser His Pro Asp Gln Val Phe Pro Leu Ala
     115                 120                 125

 tct tca ttg tat ggc att cag att gca gat cat cag ttg aga caa gcc      550
 Ser Ser Leu Tyr Gly Ile Gln Ile Ala Asp His Gln Leu Arg Gln Ala
 130                 135                 140                 145

 acc aag att gct tca gca cct gaa aaa ctc ggg cga gat cca cgg cca      598
 Thr Lys Ile Ala Ser Ala Pro Glu Lys Leu Gly Arg Asp Pro Arg Pro
                 150                 155                 160

 cag acc tcc agg ata agc cag gag cag gtc cct gag gcc tca cag ctc      646
 Gln Thr Ser Arg Ile Ser Gln Glu Gln Val Pro Glu Ala Ser Gln Leu
             165                 170                 175

 tcc cag ctg act tca aat ctg gcc cag gtg aat cgg aca aat atg act      694
 Ser Gln Leu Thr Ser Asn Leu Ala Gln Val Asn Arg Thr Asn Met Thr
         180                 185                 190

 ccc tca gac ccc ctg cag acc tcg ctg tct cca gaa ctt gtt tcc act      742
 Pro Ser Asp Pro Leu Gln Thr Ser Leu Ser Pro Glu Leu Val Ser Thr
     195                 200                 205

 cct gtt cct ccc cct cct ccc ggg gag gag acc aat ctg gaa gca tct      790
 Pro Val Pro Pro Pro Pro Pro Gly Glu Glu Thr Asn Leu Glu Ala Ser
 210                 215                 220                 225

 tcc tcc gat gag cag cct gcg tcc ctc aca ata gcc cac gtc aag cca      838
 Ser Ser Asp Glu Gln Pro Ala Ser Leu Thr Ile Ala His Val Lys Pro
                 230                 235                 240

 agc atc atg aag agg aat ggg agc ttt cca aag tac tat gcc tgc cac      886
 Ser Ile Met Lys Arg Asn Gly Ser Phe Pro Lys Tyr Tyr Ala Cys His
             245                 250                 255

 ctg tgt gga cgg cgc ttc act ctc cgg agc agc tta cgt gaa cac ctc      934
 Leu Cys Gly Arg Arg Phe Thr Leu Arg Ser Ser Leu Arg Glu His Leu
         260                 265                 270

 cag atc cac aca gga gta cct ttc aca tct agc caa cag gga gaa agt      982
 Gln Ile His Thr Gly Val Pro Phe Thr Ser Ser Gln Gln Gly Glu Ser
     275                 280                 285

 cgc gtc ccc ctg act ctc tgt agc aat gca gct gac ctc ggg aaa gat     1030
 Arg Val Pro Leu Thr Leu Cys Ser Asn Ala Ala Asp Leu Gly Lys Asp
 290                 295                 300                 305

 gcc atg gaa gtg cct gaa gcc ggg atg ata agt gac agt gag ctg cag     1078
 Ala Met Glu Val Pro Glu Ala Gly Met Ile Ser Asp Ser Glu Leu Gln
                 310                 315                 320

 cac atc tct gat tct ccc atc atc gat ggg cag cag cag tcg gaa acc     1126
 His Ile Ser Asp Ser Pro Ile Ile Asp Gly Gln Gln Gln Ser Glu Thr
             325                 330                 335

 cca ccc ccc tca gac att gct gac att gac aac ctg gag cag gcc gac     1174
 Pro Pro Pro Ser Asp Ile Ala Asp Ile Asp Asn Leu Glu Gln Ala Asp
         340                 345                 350

 cag gag agg gag gtg aag agg cgg aag tac gag tgc aca ata tgt gga     1222
 Gln Glu Arg Glu Val Lys Arg Arg Lys Tyr Glu Cys Thr Ile Cys Gly
     355                 360                 365

 cgc aaa ttt atc cag aaa agc cac tgg agg gaa cac atg tac ata cac     1270
 Arg Lys Phe Ile Gln Lys Ser His Trp Arg Glu His Met Tyr Ile His
 370                 375                 380                 385

 acc ggg aag cct ttc aag tgc agc act tgt gac aaa agc ttt tgc agg     1318
 Thr Gly Lys Pro Phe Lys Cys Ser Thr Cys Asp Lys Ser Phe Cys Arg
                 390                 395                 400

 gcc aac cag gct gcc cgc cac gtg tgc ctc aac cag agc atc gac act     1366
 Ala Asn Gln Ala Ala Arg His Val Cys Leu Asn Gln Ser Ile Asp Thr
             405                 410                 415

 tac acc atg gtg gac aaa cag act ctg gaa ctc tgc aca ttt gaa gaa     1414
 Tyr Thr Met Val Asp Lys Gln Thr Leu Glu Leu Cys Thr Phe Glu Glu
         420                 425                 430

 ggg agt cag atg gac aac atg ctg gtg caa aca aac aaa ccc tac aaa     1462
 Gly Ser Gln Met Asp Asn Met Leu Val Gln Thr Asn Lys Pro Tyr Lys
     435                 440                 445

 tgc aac ttg tgt gac aaa aca ttc tcc act ccc aat gag gtt gtt aaa     1510
 Cys Asn Leu Cys Asp Lys Thr Phe Ser Thr Pro Asn Glu Val Val Lys
 450                 455                 460                 465

 cat tca tgc caa aac cag aac tcg gat gtt ttt gcc cta gac gaa ggg     1558
 His Ser Cys Gln Asn Gln Asn Ser Asp Val Phe Ala Leu Asp Glu Gly
                 470                 475                 480

 cga tcc att ctc ctg ggc agt ggg gac tcg gaa gta acg gag cct gac     1606
 Arg Ser Ile Leu Leu Gly Ser Gly Asp Ser Glu Val Thr Glu Pro Asp
             485                 490                 495

 cac cca gtg tta gct tcc atc aaa aag gaa caa gaa acc gtc tta cta     1654
 His Pro Val Leu Ala Ser Ile Lys Lys Glu Gln Glu Thr Val Leu Leu
         500                 505                 510

 gac tga atgtcactta tctttttaaa aaactctcat ttttacaaag actatcttcc      1710
 Asp 


 ctcccttccc tgaattcaga actgtagttc tccatggcat gatacaaaca ggtccttgtt   1770

 ctcttctcct cttccccttt tccacatccc agccccacct ctgtaaaggc tttgtgcatt   1830

 ataaacctgg aatgtatcga ctttctttca ggggatattg gaaagataat ggtcattata   1890

 cttataaact caaattttga gaggttttag attattcaga agcatacttg gaactaatga   1950

 agggtatata ataaaacaac tggaatccaa tttggtaagc taaaattatg actttccctg   2010

 ggtaaaaagt cttctcagaa aaacaatgtc agaaaataac agcgtgctgc ttagaaatac   2070

 ggctgggctc tgtactatgc aaaatctaga aagtgtgggg aaactttaaa cccaagaaaa   2130

 cgttcttagt attcatcctc caggtgtctt acttcagaat gcatcctttg agattatgtc   2190

 cacttaagag aaatcatcag ttaagaaatc tactttaaca aaacaaaaag gagaaaaagt   2250

 aataatgtga tggcaatctt aatttttggg tacaacatga caagctgtga gtttgtgtgt   2310

 ttgtaagaga aaaatgtgtg ggtacttgct aataaacagg tgaattaatg cccaaaaaaa   2370

 aaaaa                                                               2375




      <210> 271
      <211> 4346
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1922)..(3298)

      <400> 271
 acgaaacgct gttcatttac ttgttgtcag gtttatattc tacaagcaga gcttgtatcg     60

 taacattatc attcaatcta ggtatatgta ttttgaagtg tagagataat gaggtagtga    120

 tactgtcttc tagaatagct actctgtctt catctctgaa attcacaggt ctggctagct    180

 gtccctaacg tcatttcctg gtctcaactc ttttaagacc ctgacatact ctgagattgg    240

 agtgaagatt tctgtgacat gctgggtggg tataggctgc tgtctcatgt cttggtcaca    300

 tcttattgtt tattttttca tatcatgtat cacaaattga aatattgctg atatacttgt    360

 ttgtcaccct gcatccttct cccattcccc aaagtaaagc ttcagcagaa tagggctttg    420

 ttgacctgtt cactgctgag tcctcagcac tgagtgcagt gcgtggtaaa tgcccagaag    480

 gtgattgtct aaatatgtta ttttttgaga atatatacga catgattatt atttgaaaca    540

 ggacaccaca aaaggtaatt tttcccttct tctacttgat ttctgtcttt tcagcctttt    600

 tcttataccc cacccctttt ttttggtggc atctcagttc aggatgttct ctgtggctgt    660

 gaatgctttc ccatcttgtt cacagttggt acctggaagg ttctctaacc ttgtttcttt    720

 ctgatgtagc ctattctgac tctgggatta ctatttaaag taattctttt aagagatatg    780

 tttggctaat tctgtaattt ttttgttatg tagactgttt gggagccaca tttcctattg    840

 atttgatcac accttatttt ttccttgtca taaatggtcc tttttggatg agttactgtg    900

 tgagttctga ccctgtcaga attgatattc ttaggaatcc tgactttaat atacacagaa    960

 caggaaaagt ttccttgtca taaatggtcc tttttggatg agttactgtg tgagttctga   1020

 ccctgtcaga attgatattc ttaggaatcc tgactttaat atacacagaa caggaaaagt   1080

 catgataggc acccttgggt atatatggta acatgttagt tctcttcaag actgtgcatg   1140

 gcttacaggg atcacaggac tgtgtgagtt aagcaacagt ttaaacctga tgtattgctc   1200

 tcccagaaag tagtattctt aaggtattta ccccagatct gcaagtgtct gtgtttctct   1260

 gggagggaac ccccaaacct ggaatgctca tccatatgca ttccaacctg cctctgagat   1320

 gttaggcaag cctcagcaga ggttcttgac agttttttgg actatagacc ttttggcaaa   1380

 tctgacaaac tattgacctt ctcccagaga tacttattta cataaaccca caaattttac   1440

 atatatcatt caggagtgca tagattcctg aaggccatcc agtgaccaag gttaaacacc   1500

 tctaatctga atagtaataa taataataat tattattatt actgagttac agatgatttg   1560

 gaaaatctct ggagagactg aaaatctctt attaattaag aataacctta gaagcactca   1620

 gaaaatttct gttcttgcac gttcttctcc catcttggaa tatccaagag ccagactaga   1680

 tcatccgaat cagctcttga ccagctcaag attgagaatt caggctgggt ttattttgaa   1740

 gttactaact atgtcttttg tgatcttaca ggtatctctg cattagccag attggacata   1800

 tgtaaaggga catcagtata tctggatcat cagattgtgc ttcaagaaga ccatagggaa   1860

 gaacgcattt tcatcttgct gcaaaagttg caatagaaga tctgaaggtt tgaatgggcc   1920

 a    atg agt atc ctc atc att gaa gca ttc tat gga ggc tcc cat aaa    1966
      Met Ser Ile Leu Ile Ile Glu Ala Phe Tyr Gly Gly Ser His Lys
        1               5                  10                  15

 cag ctg gtg gat ctt ctt caa gaa gag tta gga gac tgt gtc gtt tat     2014
 Gln Leu Val Asp Leu Leu Gln Glu Glu Leu Gly Asp Cys Val Val Tyr
                  20                  25                  30

 acc ctt cct gca aag aaa tgg cat tgg aga gcc cgg aca tct gct tta     2062
 Thr Leu Pro Ala Lys Lys Trp His Trp Arg Ala Arg Thr Ser Ala Leu
              35                  40                  45

 tat ttc tct cag acc att ccc atc agt gag cat tac agg acc ctc ttt     2110
 Tyr Phe Ser Gln Thr Ile Pro Ile Ser Glu His Tyr Arg Thr Leu Phe
          50                  55                  60

 gca agt tca gtg ctt aac ctg acc gaa ctg gct gcc ctt cgg cct gac     2158
 Ala Ser Ser Val Leu Asn Leu Thr Glu Leu Ala Ala Leu Arg Pro Asp
      65                  70                  75

 ctt ggg aaa ctg aaa aag att ctg tat ttt cac gag aac cag ttg ata     2206
 Leu Gly Lys Leu Lys Lys Ile Leu Tyr Phe His Glu Asn Gln Leu Ile
  80                  85                  90                  95

 tat cct gtc aag aaa tgt cag gag agg gat ttc caa tat gga tac aac     2254
 Tyr Pro Val Lys Lys Cys Gln Glu Arg Asp Phe Gln Tyr Gly Tyr Asn
                 100                 105                 110

 caa att ctt tca tgc ctg gtg gct gat gtg gtt gta ttc aac tca gtt     2302
 Gln Ile Leu Ser Cys Leu Val Ala Asp Val Val Val Phe Asn Ser Val
             115                 120                 125

 ttt aat atg gaa tca ttt ctc act tcc atg gga aaa ttt atg aag ctg     2350
 Phe Asn Met Glu Ser Phe Leu Thr Ser Met Gly Lys Phe Met Lys Leu
         130                 135                 140

 att cct gat cac aga ccc aag gat ctg gaa agc atc atc aga ccc aag     2398
 Ile Pro Asp His Arg Pro Lys Asp Leu Glu Ser Ile Ile Arg Pro Lys
     145                 150                 155

 tgc caa gtt att tac ttt ccc atc agg ttt cct gat gtg agc aga ttc     2446
 Cys Gln Val Ile Tyr Phe Pro Ile Arg Phe Pro Asp Val Ser Arg Phe
 160                 165                 170                 175

 atg ccc aag cac aaa aca acc cat tta aag aag atg ctc ggc ctt aaa     2494
 Met Pro Lys His Lys Thr Thr His Leu Lys Lys Met Leu Gly Leu Lys
                 180                 185                 190

 gga aat ggc ggt gcg gtt ctg tcc atg gcc ctt cct ttt cag cca gag     2542
 Gly Asn Gly Gly Ala Val Leu Ser Met Ala Leu Pro Phe Gln Pro Glu
             195                 200                 205

 cag aga gat tca gag gat tta ttg aag aat ttt aat tca gag cgt gat     2590
 Gln Arg Asp Ser Glu Asp Leu Leu Lys Asn Phe Asn Ser Glu Arg Asp
         210                 215                 220

 aca cac tgt ggc ctt gat act gca cga caa gaa tat ttg ggt aac tca     2638
 Thr His Cys Gly Leu Asp Thr Ala Arg Gln Glu Tyr Leu Gly Asn Ser
     225                 230                 235

 tta aga cag gaa tca gac ttg aaa aaa tcc acc tcg tca gat aat tca     2686
 Leu Arg Gln Glu Ser Asp Leu Lys Lys Ser Thr Ser Ser Asp Asn Ser
 240                 245                 250                 255

 agc tct cat cat ggt gaa aat aaa caa aac ctg act gtt gat ccc tgt     2734
 Ser Ser His His Gly Glu Asn Lys Gln Asn Leu Thr Val Asp Pro Cys
                 260                 265                 270

 gac att ttg ggt gga ggt gat aat cac cat aca ctg cta ccc atc tgc     2782
 Asp Ile Leu Gly Gly Gly Asp Asn His His Thr Leu Leu Pro Ile Cys
             275                 280                 285

 tgg cct ctc agg tgg gag cat gat aaa gat cca gaa agc ttt ttt aag     2830
 Trp Pro Leu Arg Trp Glu His Asp Lys Asp Pro Glu Ser Phe Phe Lys
         290                 295                 300

 gta tta atg cat ctt aaa gac tta gga ctc aat ttc cac gtg tct gta     2878
 Val Leu Met His Leu Lys Asp Leu Gly Leu Asn Phe His Val Ser Val
     305                 310                 315

 ctt gga gaa acc ttc aca gat gtc cca gat att ttt tca gag gcc aaa     2926
 Leu Gly Glu Thr Phe Thr Asp Val Pro Asp Ile Phe Ser Glu Ala Lys
 320                 325                 330                 335

 aag gca ttg gga tct tct gtc tta cac tgg ggc tac tta ccc agc aaa     2974
 Lys Ala Leu Gly Ser Ser Val Leu His Trp Gly Tyr Leu Pro Ser Lys
                 340                 345                 350

 gat gac tat ttc caa gta ctg tgc atg gct gat gtt gtc atc tca aca     3022
 Asp Asp Tyr Phe Gln Val Leu Cys Met Ala Asp Val Val Ile Ser Thr
             355                 360                 365

 gct aag cat gaa ttc ttt gga gtg gca atg ttg gaa gct gtg tac tgt     3070
 Ala Lys His Glu Phe Phe Gly Val Ala Met Leu Glu Ala Val Tyr Cys
         370                 375                 380

 ggg tgt tac cca ctt tgt cct aaa gat ttg gtt tat ccc gaa ata ttt     3118
 Gly Cys Tyr Pro Leu Cys Pro Lys Asp Leu Val Tyr Pro Glu Ile Phe
     385                 390                 395

 cca gct gaa tat ctg tat tct aca cct gaa cag ctt tca aaa agg ctc     3166
 Pro Ala Glu Tyr Leu Tyr Ser Thr Pro Glu Gln Leu Ser Lys Arg Leu
 400                 405                 410                 415

 cag aat ttc tgc aag aga cca gat att ata aga aaa cat ctc tat aag     3214
 Gln Asn Phe Cys Lys Arg Pro Asp Ile Ile Arg Lys His Leu Tyr Lys
                 420                 425                 430

 ggt gaa atc gct ccg ttt tct tgg gca gcc cta cat ggt aaa ttc agg     3262
 Gly Glu Ile Ala Pro Phe Ser Trp Ala Ala Leu His Gly Lys Phe Arg
             435                 440                 445

 tct ctg ctt aca aca gaa cct agg gaa gat ttg tga caga tggggctaag     3312
 Ser Leu Leu Thr Thr Glu Pro Arg Glu Asp Leu 
         450                 455

 tcacaaactt gcagcctaag gcagaatctg aagaactttc cagagtgtgc ccatatttac   3372

 ctgatcagag agaaaagaaa atctgcagag gaagctgagc ctggctgctt gtcatagctg   3432

 acacagagcc atctgccaca aacctgtggc ggcttcagat ctccaatccc tgccaccacc   3492

 ccaactcaaa ttaaatacag attcctagag acgttatgat ggttacacat gtcctcggca   3552

 tcacatgtag gagactgttc aaaaaaaata tgtggcctgt tgtataaccg cactcatgta   3612

 tcccatatgt ggtgccacat tgaatttccg gttgaatccg tttttatcct ttgtactgga   3672

 tgacatggtg cctgaattct ttcttttcgc cgacacgatg gcagccaaac tgcagcttca   3732

 aacgctcaca cttggctggg tttctaccta ggttgccagg ttatcatcgg agccttcttg   3792

 tgtcctcaaa gggccacgag gcctgaaagg aggatcagaa tgctttggga ttaattgggc   3852

 agccatcgca gaattgtttg tgggcaaagg gctgctttag cacttttctt ttagcaaatt   3912

 aatgactctc aggcacaggg ggttttaagt gaaggtatta ataagaggtc tggcaggtat   3972

 tcccatgatt cacagagtta catttgcatt taattaatct taaagttgca agataaacag   4032

 ctgtaattcg gacaaacatg acaaacacag tgaagccaac tatcccataa aatgaacact   4092

 gacatacttg ttttaatttt tttcccagcg taaaaataga aaaatcaaaa tactcctaac   4152

 aaaaccagtg attttgatag aaatatttct ccaatatact tgcatccacc tacaaatata   4212

 accttttcaa gataaatcgc ttatgatttc aatagtcaaa ctgctgtgtt tgttgatgta   4272

 aagatgtttt gaatggctag atggtaaaat aaattcttaa taaagtaccc actgcaattt   4332

 ttaaaaaaaa aaaa                                                     4346




      <210> 272
      <211> 4682
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (399)..(3083)

      <400> 272
 catcaataac cttttcagat gaaagcttat agttattctt caataaaaat tcattgacta     60

 agaagtttag agctctcttt tcaagaggtt tgattggctc ctgaatttca ggacttgatt    120

 tgtaattttt attgaagaat aactataagc ttacatcaat aaccttttca gatgaaaacg    180

 atgatcagga ttttgaatta tgggatgatg taggattaaa cattccaaaa cctccagact    240

 tattgcaact ctaccgggat tttggaaatc atcaagtaac tggaaaagat cttgtagatg    300

 tggccagtgg agtagaagaa gatgaattag aggcccttac accaattata agcaaccttc    360

 ctccaactct tgaaactccc cagcctgcag agaactcc    atg tta gta cag aaa     413
                                              Met Leu Val Gln Lys
                                                1               5

 tta gaa gat aaa att agt ttg tta aat agt gag aaa tgg tca ttg atg      461
 Leu Glu Asp Lys Ile Ser Leu Leu Asn Ser Glu Lys Trp Ser Leu Met
                  10                  15                  20

 gag caa atc aga aga ctt aaa agt gaa atg gac ttc ctc aaa aat gaa      509
 Glu Gln Ile Arg Arg Leu Lys Ser Glu Met Asp Phe Leu Lys Asn Glu
              25                  30                  35

 cac ttt gcc atc cca gca gtt tgt gac tct gtt cag cct cct ttg gat      557
 His Phe Ala Ile Pro Ala Val Cys Asp Ser Val Gln Pro Pro Leu Asp
          40                  45                  50

 cag ttg ccc cac aaa gac tct gag gac agt gga cag cat cca gat gta      605
 Gln Leu Pro His Lys Asp Ser Glu Asp Ser Gly Gln His Pro Asp Val
      55                  60                  65

 aat agt tca gac aag gga aaa aac aca gac atc cat ctt tca ata tca      653
 Asn Ser Ser Asp Lys Gly Lys Asn Thr Asp Ile His Leu Ser Ile Ser
  70                  75                  80                  85

 gat gaa gct gat tcc act att cct aaa gag aat tcc cca aat tca ttc      701
 Asp Glu Ala Asp Ser Thr Ile Pro Lys Glu Asn Ser Pro Asn Ser Phe
                  90                  95                 100

 ccc agg aga gaa aga gaa gga atg cca cct tct tct cta tca agt aaa      749
 Pro Arg Arg Glu Arg Glu Gly Met Pro Pro Ser Ser Leu Ser Ser Lys
             105                 110                 115

 aag aca gtt cat ttt gat aaa cct aat agg aaa ttg tct cct gca ttc      797
 Lys Thr Val His Phe Asp Lys Pro Asn Arg Lys Leu Ser Pro Ala Phe
         120                 125                 130

 cat caa gca cta ctc tct ttt tgt cga atg tca gca gat agt cgt tta      845
 His Gln Ala Leu Leu Ser Phe Cys Arg Met Ser Ala Asp Ser Arg Leu
     135                 140                 145

 gga tac gag gtg tct cgt att gca gac agt gaa aaa agc gtt atg tta      893
 Gly Tyr Glu Val Ser Arg Ile Ala Asp Ser Glu Lys Ser Val Met Leu
 150                 155                 160                 165

 atg ctg gga cgc tgc ctg cca cac att gtt ccc aat gtg cta ttg gca      941
 Met Leu Gly Arg Cys Leu Pro His Ile Val Pro Asn Val Leu Leu Ala
                 170                 175                 180

 aag aga gag gag ttg atc ccc ctc ata ttg tgt aca gca tgt cta cat      989
 Lys Arg Glu Glu Leu Ile Pro Leu Ile Leu Cys Thr Ala Cys Leu His
             185                 190                 195

 cct gag cct aaa gag cga gat cag ctt ctc cac ata ctt ttc aat ttg     1037
 Pro Glu Pro Lys Glu Arg Asp Gln Leu Leu His Ile Leu Phe Asn Leu
         200                 205                 210

 atc aag agg cca gat gat gag caa agg caa atg ata ctg aca ggt tgt     1085
 Ile Lys Arg Pro Asp Asp Glu Gln Arg Gln Met Ile Leu Thr Gly Cys
     215                 220                 225

 gtg gca ttt gcg cgt cat gtt gga cca aca cgt gta gaa gct gaa ctt     1133
 Val Ala Phe Ala Arg His Val Gly Pro Thr Arg Val Glu Ala Glu Leu
 230                 235                 240                 245

 tta cca cag tgt tgg gaa cag att aat cac aaa tac cca gaa aga cga     1181
 Leu Pro Gln Cys Trp Glu Gln Ile Asn His Lys Tyr Pro Glu Arg Arg
                 250                 255                 260

 ctg ctt gtg gca gaa tcc tgt gga gca ctg gca cct tac ctt cct aaa     1229
 Leu Leu Val Ala Glu Ser Cys Gly Ala Leu Ala Pro Tyr Leu Pro Lys
             265                 270                 275

 gaa atc cgt agc tcc ttg gtt ctt tca atg ttg caa caa atg tta atg     1277
 Glu Ile Arg Ser Ser Leu Val Leu Ser Met Leu Gln Gln Met Leu Met
         280                 285                 290

 gaa gat aag gca gat ttg gta aga gaa gct gtt atc aaa agc ctt ggt     1325
 Glu Asp Lys Ala Asp Leu Val Arg Glu Ala Val Ile Lys Ser Leu Gly
     295                 300                 305

 atc att atg gga tac att gat gat cca gac aaa tat cat cag ggt ttt     1373
 Ile Ile Met Gly Tyr Ile Asp Asp Pro Asp Lys Tyr His Gln Gly Phe
 310                 315                 320                 325

 gaa ttg ttg ctg tca gcc ttg ggt gat ccc tca gaa aga gta gtt agt     1421
 Glu Leu Leu Leu Ser Ala Leu Gly Asp Pro Ser Glu Arg Val Val Ser
                 330                 335                 340

 gct aca cat caa gta ttt tta cca gct tac gct gcg tgg act aca gaa     1469
 Ala Thr His Gln Val Phe Leu Pro Ala Tyr Ala Ala Trp Thr Thr Glu
             345                 350                 355

 ctt gga aat tta cag tct cat ctt ata ctt aca cta ctg aac aag att     1517
 Leu Gly Asn Leu Gln Ser His Leu Ile Leu Thr Leu Leu Asn Lys Ile
         360                 365                 370

 gaa aaa ctt ctc agg gaa gga gaa cat gga ctg gat gaa cac aaa ctc     1565
 Glu Lys Leu Leu Arg Glu Gly Glu His Gly Leu Asp Glu His Lys Leu
     375                 380                 385

 cac atg tat ctt tct gcc ttg cag tcc ttg atc cca tct ctc ttt gca     1613
 His Met Tyr Leu Ser Ala Leu Gln Ser Leu Ile Pro Ser Leu Phe Ala
 390                 395                 400                 405

 tta gtg cta cag aat gca cct ttc tcc agc aaa gcc aag ctt cat ggt     1661
 Leu Val Leu Gln Asn Ala Pro Phe Ser Ser Lys Ala Lys Leu His Gly
                 410                 415                 420

 gaa gtg cca cag ata gaa gtg act agg ttt cct cgg cct atg tcg cct     1709
 Glu Val Pro Gln Ile Glu Val Thr Arg Phe Pro Arg Pro Met Ser Pro
             425                 430                 435

 ctt caa gat gtg tcc act att atc gga agt cgt gag caa ttg gca gtg     1757
 Leu Gln Asp Val Ser Thr Ile Ile Gly Ser Arg Glu Gln Leu Ala Val
         440                 445                 450

 ctg ctg caa ctt tat gac tac cag cta gaa caa gag ggt aca aca ggc     1805
 Leu Leu Gln Leu Tyr Asp Tyr Gln Leu Glu Gln Glu Gly Thr Thr Gly
     455                 460                 465

 tgg gag agt tta ctg tgg gtt gtc aat caa ttg ttg cca caa ctt ata     1853
 Trp Glu Ser Leu Leu Trp Val Val Asn Gln Leu Leu Pro Gln Leu Ile
 470                 475                 480                 485

 gaa ata gtt ggc aaa att aat gtt act tca act gcc tgt gtc cat gaa     1901
 Glu Ile Val Gly Lys Ile Asn Val Thr Ser Thr Ala Cys Val His Glu
                 490                 495                 500

 ttc tcc aga ttt ttc tgg cgc ctt tgc cgg aca ttt ggc aaa att ttt     1949
 Phe Ser Arg Phe Phe Trp Arg Leu Cys Arg Thr Phe Gly Lys Ile Phe
             505                 510                 515

 aca aac act aag gta aaa cct cag ttc cag gag att tta aga cta tct     1997
 Thr Asn Thr Lys Val Lys Pro Gln Phe Gln Glu Ile Leu Arg Leu Ser
         520                 525                 530

 gaa gaa aac att gat tcc tca gca gga aat ggg gtc ctc act aaa gct     2045
 Glu Glu Asn Ile Asp Ser Ser Ala Gly Asn Gly Val Leu Thr Lys Ala
     535                 540                 545

 aca gtt ccc att tat gca aca gga gtc ctt acg tgt tat att cag ata     2093
 Thr Val Pro Ile Tyr Ala Thr Gly Val Leu Thr Cys Tyr Ile Gln Ile
 550                 555                 560                 565

 aag gag tat ttg cat ata cat aat gag ata tct tgg gaa tgg gac cca     2141
 Lys Glu Tyr Leu His Ile His Asn Glu Ile Ser Trp Glu Trp Asp Pro
                 570                 575                 580

 agt cta aac aca aaa tgt gtt tca tat aca cat tat aca cat agc ctg     2189
 Ser Leu Asn Thr Lys Cys Val Ser Tyr Thr His Tyr Thr His Ser Leu
             585                 590                 595

 aag gaa gaa gac cga aaa ctg tta gtt gga ttc tta gaa gat gta atg     2237
 Lys Glu Glu Asp Arg Lys Leu Leu Val Gly Phe Leu Glu Asp Val Met
         600                 605                 610

 acg ctg ctt tca tta tct cat gct cct ctt gat agc ctg aag gct tct     2285
 Thr Leu Leu Ser Leu Ser His Ala Pro Leu Asp Ser Leu Lys Ala Ser
     615                 620                 625

 ttt gtg gaa ttg ggt gca aac cca gcc tac cat gag tta cta tta act     2333
 Phe Val Glu Leu Gly Ala Asn Pro Ala Tyr His Glu Leu Leu Leu Thr
 630                 635                 640                 645

 gtt ttg tgg tat ggt gtt gtc cat act tca gca ctc gtg agg tgt act     2381
 Val Leu Trp Tyr Gly Val Val His Thr Ser Ala Leu Val Arg Cys Thr
                 650                 655                 660

 gct gct aga atg ttt gag ctg ttg gtg aag ggg gtg aat gaa act ctg     2429
 Ala Ala Arg Met Phe Glu Leu Leu Val Lys Gly Val Asn Glu Thr Leu
             665                 670                 675

 gta gct cag agg gtt gtt cct gct ctc att act ctc tcc agt gac cct     2477
 Val Ala Gln Arg Val Val Pro Ala Leu Ile Thr Leu Ser Ser Asp Pro
         680                 685                 690

 gaa atc tct gtc agg att gcc aca att cca gcc ttt ggc act att atg     2525
 Glu Ile Ser Val Arg Ile Ala Thr Ile Pro Ala Phe Gly Thr Ile Met
     695                 700                 705

 gaa aca gta att caa aga gag ttg ctg gaa aga gtg aaa atg cag ttg     2573
 Glu Thr Val Ile Gln Arg Glu Leu Leu Glu Arg Val Lys Met Gln Leu
 710                 715                 720                 725

 gct tct ttc ctg gaa gat cct cag tat caa gac caa cat tct ttg cat     2621
 Ala Ser Phe Leu Glu Asp Pro Gln Tyr Gln Asp Gln His Ser Leu His
                 730                 735                 740

 aca gag atc ata aaa aca ttt ggt aga gtt ggc cct aac gca gaa ccc     2669
 Thr Glu Ile Ile Lys Thr Phe Gly Arg Val Gly Pro Asn Ala Glu Pro
             745                 750                 755

 agg ttc cga gat gag ttt gtt ata cca cat ttg cat aag tta gcc ttg     2717
 Arg Phe Arg Asp Glu Phe Val Ile Pro His Leu His Lys Leu Ala Leu
         760                 765                 770

 gtg aac aac tta cag att gtg gat tct aaa aga ctg gac att gct acg     2765
 Val Asn Asn Leu Gln Ile Val Asp Ser Lys Arg Leu Asp Ile Ala Thr
     775                 780                 785

 cat ctt ttt gaa gcc tac agt gca ctt tcc tgt tgt ttc att tca gag     2813
 His Leu Phe Glu Ala Tyr Ser Ala Leu Ser Cys Cys Phe Ile Ser Glu
 790                 795                 800                 805

 gat tta atg gtt aat cac ttt tta cct ggt ctc aga tgt tta cgg act     2861
 Asp Leu Met Val Asn His Phe Leu Pro Gly Leu Arg Cys Leu Arg Thr
                 810                 815                 820

 gac atg gaa cat ctc tct cca gag cat gag gtt att tta agt tcc atg     2909
 Asp Met Glu His Leu Ser Pro Glu His Glu Val Ile Leu Ser Ser Met
             825                 830                 835

 ata aaa gaa tgt gaa caa aaa gtt gaa aac aag acc gtc caa gag cct     2957
 Ile Lys Glu Cys Glu Gln Lys Val Glu Asn Lys Thr Val Gln Glu Pro
         840                 845                 850

 caa ggc tca atg tca att gct gca agc tta gtg agt gaa gat aca aag     3005
 Gln Gly Ser Met Ser Ile Ala Ala Ser Leu Val Ser Glu Asp Thr Lys
     855                 860                 865

 acc aag ttt ttg aac aaa atg ggc cag ttg aca aca tca ggt gcc atg     3053
 Thr Lys Phe Leu Asn Lys Met Gly Gln Leu Thr Thr Ser Gly Ala Met
 870                 875                 880                 885

 ttg gcc aat gta ttt cag aga aag aag tag a agcaggaaag aagcccccag     3104
 Leu Ala Asn Val Phe Gln Arg Lys Lys 
                 890

 taaacactaa gatggacctc aagccgactg gttccttgta cttgaagtac ttgccttttt   3164

 tgtttcctca gttttatgtt cttgcattat aattttatcc taacctccaa agatatttgc   3224

 actgctttta attactgctg tatatttgtt gattttggag ttacaactgt ggtgatagaa   3284

 aattgagttg atggtctgta ccaagtccct tgtctatgtt cttgtctttc agaataattt   3344

 ttatataaat atatatatag tgaagaagtt ttttttaatt tttggatggg atattcgcaa   3404

 atatctgtat tatacactaa gctattacaa tggtacttaa aataatgtaa atttgaagtc   3464

 attgttataa aataataaag tggagattac ttaagtattt aaattatgaa agaataatgc   3524

 agacttttta ttgtttctta actgactaga aagagccacc agcattactc tgtgcctttt   3584

 ggacatcagt ttgtgtgttc tgtaggaatt gtgtgcattc cattcacaca gtatttcttt   3644

 aggatgctgt gatgatttga attacaaatc ctacagtcaa tagctaaaga cgaaaccttc   3704

 atttcagaac tctcatgaat attctttaag tgctatttaa acctccccag cacttagatg   3764

 catataatgg acttacctga ggaaagacag cacataggca tggggagagg taaccaaggt   3824

 gaattttaca aactggtgta tagtagattt aaatgctcaa aaataaatgt aactgagaag   3884

 agttaataat tgtgagattt ttcccaaatt gagatacaga agaaaatata gtttgaatct   3944

 gaaatttaac acttatttat gtaaaacatt ttatttaaga tattttctaa tgattttaat   4004

 tttagagagt accttttcat tctgtgtgtt acagagaagt actgaaaagt taaggacact   4064

 tgggggctac ttttttccct ctaaactaaa aaagacattg gctgaattat aactagttag   4124

 ttatcacctc gtcccttaaa gtcagtgacc tcctgtgttt gatgtatatt acatagagtc   4184

 ttaagtcagt gtacagttcc actggaattt gacagttgtc tctacagtca tgcaactcga   4244

 agtagaaaag agtgctggac ataggaaggg ggtgcttggt ttgaggggtt aatgtgaggc   4304

 ctttttgaaa aatgaatatt ttgataaaaa gaattcttgt tttagcacag ttgatgcaca   4364

 taagtgattc tcatatttgt tgtataaact ggtttaatac atttggaaca tagttggatt   4424

 acattcattt cctgggaaag ctagcttacc atacattcaa gtttataaaa caatttgcca   4484

 taggcaaagc catttaaaaa gttcattctg aaattatttc atttacctac agtgaaataa   4544

 ttgtgaacta agtagtcttt ctgaaaactg ttgggttcta ggcattcctg agaaattgaa   4604

 agtggctacc tttcatgtca aaaatgttga tctattataa ataaaatgtt tttgcatatg   4664

 tttttgaaaa aaaaaaaa                                                 4682




      <210> 273
      <211> 4580
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (399)..(2981)

      <400> 273
 catcaataac cttttcagat gaaagcttat agttattctt caataaaaat tcattgacta     60

 agaagtttag agctctcttt tcaagaggtt tgattggctc ctgaatttca ggacttgatt    120

 tgtaattttt attgaagaat aactataagc ttacatcaat aaccttttca gatgaaaacg    180

 atgatcagga ttttgaatta tgggatgatg taggattaaa cattccaaaa cctccagact    240

 tattgcaact ctaccgggat tttggaaatc atcaagtaac tggaaaagat cttgtagatg    300

 tggccagtgg agtagaagaa gatgaattag aggcccttac accaattata agcaaccttc    360

 ctccaactct tgaaactccc cagcctgcag agaactcc    atg tta gta cag aaa     413
                                              Met Leu Val Gln Lys
                                                1               5

 tta gaa gat aaa att agt ttg tta aat agt gag aaa tgg tca ttg atg      461
 Leu Glu Asp Lys Ile Ser Leu Leu Asn Ser Glu Lys Trp Ser Leu Met
                  10                  15                  20

 gag caa atc aga aga ctt aaa agt gaa atg gac ttc ctc aaa aat gaa      509
 Glu Gln Ile Arg Arg Leu Lys Ser Glu Met Asp Phe Leu Lys Asn Glu
              25                  30                  35

 cac ttt gcc atc cca gca gtt tgt gac tct gtt cag cct cct ttg gat      557
 His Phe Ala Ile Pro Ala Val Cys Asp Ser Val Gln Pro Pro Leu Asp
          40                  45                  50

 cag ttg ccc cac aaa gac tct gag gac agt gga cag cat cca gat gta      605
 Gln Leu Pro His Lys Asp Ser Glu Asp Ser Gly Gln His Pro Asp Val
      55                  60                  65

 aat agt tca gac aag gga aaa aac aca gac atc cat ctt tca ata tca      653
 Asn Ser Ser Asp Lys Gly Lys Asn Thr Asp Ile His Leu Ser Ile Ser
  70                  75                  80                  85

 gat gaa gct gat tcc act att cct aaa gag aat tcc cca aat tca ttc      701
 Asp Glu Ala Asp Ser Thr Ile Pro Lys Glu Asn Ser Pro Asn Ser Phe
                  90                  95                 100

 ccc agg aga gaa aga gaa gga atg cca cct tct tct cta tca agt aaa      749
 Pro Arg Arg Glu Arg Glu Gly Met Pro Pro Ser Ser Leu Ser Ser Lys
             105                 110                 115

 aag aca gtt cat ttt gat aaa cct aat agg aaa ttg tct cct gca ttc      797
 Lys Thr Val His Phe Asp Lys Pro Asn Arg Lys Leu Ser Pro Ala Phe
         120                 125                 130

 cat caa gca cta ctc tct ttt tgt cga atg tca gca gat agt cgt tta      845
 His Gln Ala Leu Leu Ser Phe Cys Arg Met Ser Ala Asp Ser Arg Leu
     135                 140                 145

 gga tac gag gtg tct cgt att gca gac agt gaa aaa agc gtt atg tta      893
 Gly Tyr Glu Val Ser Arg Ile Ala Asp Ser Glu Lys Ser Val Met Leu
 150                 155                 160                 165

 atg ctg gga cgc tgc ctg cca cac att gtt ccc aat gtg cta ttg gca      941
 Met Leu Gly Arg Cys Leu Pro His Ile Val Pro Asn Val Leu Leu Ala
                 170                 175                 180

 aag aga gag gag ttg atc ccc ctc ata ttg tgt aca gca tgt cta cat      989
 Lys Arg Glu Glu Leu Ile Pro Leu Ile Leu Cys Thr Ala Cys Leu His
             185                 190                 195

 cct gag cct aaa gag cga gat cag ctt ctc cac ata ctt ttc aat ttg     1037
 Pro Glu Pro Lys Glu Arg Asp Gln Leu Leu His Ile Leu Phe Asn Leu
         200                 205                 210

 atc aag agg cca gat gat gag caa agg caa atg ata ctg aca ggt tgt     1085
 Ile Lys Arg Pro Asp Asp Glu Gln Arg Gln Met Ile Leu Thr Gly Cys
     215                 220                 225

 gtg gca ttt gcg cgt cat gtt gga cca aca cgt gta gaa gct gaa ctt     1133
 Val Ala Phe Ala Arg His Val Gly Pro Thr Arg Val Glu Ala Glu Leu
 230                 235                 240                 245

 tta cca cag tgt tgg gaa cag att aat cac aaa tac cca gaa aga cga     1181
 Leu Pro Gln Cys Trp Glu Gln Ile Asn His Lys Tyr Pro Glu Arg Arg
                 250                 255                 260

 ctg ctt gtg gca gaa tcc tgt gga gca ctg gca cct tac ctt cct aaa     1229
 Leu Leu Val Ala Glu Ser Cys Gly Ala Leu Ala Pro Tyr Leu Pro Lys
             265                 270                 275

 gaa atc cgt agc tcc ttg gtt ctt tca atg ttg caa caa atg tta atg     1277
 Glu Ile Arg Ser Ser Leu Val Leu Ser Met Leu Gln Gln Met Leu Met
         280                 285                 290

 gaa gat aag gca gat ttg gta aga gaa gct gtt atc aaa agc ctt ggt     1325
 Glu Asp Lys Ala Asp Leu Val Arg Glu Ala Val Ile Lys Ser Leu Gly
     295                 300                 305

 atc att atg gga tac att gat gat cca gac aaa tat cat cag ggt ttt     1373
 Ile Ile Met Gly Tyr Ile Asp Asp Pro Asp Lys Tyr His Gln Gly Phe
 310                 315                 320                 325

 gaa ttg ttg ctg tca gcc ttg ggt gat ccc tca gaa aga gta gtt agt     1421
 Glu Leu Leu Leu Ser Ala Leu Gly Asp Pro Ser Glu Arg Val Val Ser
                 330                 335                 340

 gct aca cat caa gta ttt tta cca gct tac gct gcg tgg act aca gaa     1469
 Ala Thr His Gln Val Phe Leu Pro Ala Tyr Ala Ala Trp Thr Thr Glu
             345                 350                 355

 ctt gga aat tta cag tct cat ctt ata ctt aca cta ctg aac aag att     1517
 Leu Gly Asn Leu Gln Ser His Leu Ile Leu Thr Leu Leu Asn Lys Ile
         360                 365                 370

 gaa aaa ctt ctc agg gaa gga gaa cat gga ctg gat gaa cac aaa ctc     1565
 Glu Lys Leu Leu Arg Glu Gly Glu His Gly Leu Asp Glu His Lys Leu
     375                 380                 385

 cac atg tat ctt tct gcc ttg cag tcc ttg atc cca tct ctc ttt gca     1613
 His Met Tyr Leu Ser Ala Leu Gln Ser Leu Ile Pro Ser Leu Phe Ala
 390                 395                 400                 405

 tta gtg cta cag aat gca cct ttc tcc agc aaa gcc aag ctt cat ggt     1661
 Leu Val Leu Gln Asn Ala Pro Phe Ser Ser Lys Ala Lys Leu His Gly
                 410                 415                 420

 gaa gtg cca cag ata gaa gtg act agg ttt cct cgg cct atg tcg cct     1709
 Glu Val Pro Gln Ile Glu Val Thr Arg Phe Pro Arg Pro Met Ser Pro
             425                 430                 435

 ctt caa gat gtg tcc act att atc gga agt cgt gag caa ttg gca gtg     1757
 Leu Gln Asp Val Ser Thr Ile Ile Gly Ser Arg Glu Gln Leu Ala Val
         440                 445                 450

 ctg ctg caa ctt tat gac tac cag cta gaa caa gag ggt aca aca ggc     1805
 Leu Leu Gln Leu Tyr Asp Tyr Gln Leu Glu Gln Glu Gly Thr Thr Gly
     455                 460                 465

 tgg gag agt tta ctg tgg gtt gtc aat caa ttg ttg cca caa ctt ata     1853
 Trp Glu Ser Leu Leu Trp Val Val Asn Gln Leu Leu Pro Gln Leu Ile
 470                 475                 480                 485

 gaa ata gtt ggc aaa att aat gtt act tca act gcc tgt gtc cat gaa     1901
 Glu Ile Val Gly Lys Ile Asn Val Thr Ser Thr Ala Cys Val His Glu
                 490                 495                 500

 ttc tcc aga ttt ttc tgg cgc ctt tgc cgg aca ttt ggc aaa att ttt     1949
 Phe Ser Arg Phe Phe Trp Arg Leu Cys Arg Thr Phe Gly Lys Ile Phe
             505                 510                 515

 aca aac act aag gta aaa cct cag ttc cag gag att tta aga cta tct     1997
 Thr Asn Thr Lys Val Lys Pro Gln Phe Gln Glu Ile Leu Arg Leu Ser
         520                 525                 530

 gaa gaa aac att gat tcc tca gca gga aat ggg gtc ctc act aaa gct     2045
 Glu Glu Asn Ile Asp Ser Ser Ala Gly Asn Gly Val Leu Thr Lys Ala
     535                 540                 545

 aca gtt ccc att tat gca aca gga gtc ctt acg tgt tat att cag gaa     2093
 Thr Val Pro Ile Tyr Ala Thr Gly Val Leu Thr Cys Tyr Ile Gln Glu
 550                 555                 560                 565

 gaa gac cga aaa ctg tta gtt gga ttc tta gaa gat gta atg acg ctg     2141
 Glu Asp Arg Lys Leu Leu Val Gly Phe Leu Glu Asp Val Met Thr Leu
                 570                 575                 580

 ctt tca tta tct cat gct cct ctt gat agc ctg aag gct tct ttt gtg     2189
 Leu Ser Leu Ser His Ala Pro Leu Asp Ser Leu Lys Ala Ser Phe Val
             585                 590                 595

 gaa ttg ggt gca aac cca gcc tac cat gag tta cta tta act gtt ttg     2237
 Glu Leu Gly Ala Asn Pro Ala Tyr His Glu Leu Leu Leu Thr Val Leu
         600                 605                 610

 tgg tat ggt gtt gtc cat act tca gca ctc gtg agg tgt act gct gct     2285
 Trp Tyr Gly Val Val His Thr Ser Ala Leu Val Arg Cys Thr Ala Ala
     615                 620                 625

 aga atg ttt gag ctg ttg gtg aag ggg gtg aat gaa act ctg gta gct     2333
 Arg Met Phe Glu Leu Leu Val Lys Gly Val Asn Glu Thr Leu Val Ala
 630                 635                 640                 645

 cag agg gtt gtt cct gct ctc att act ctc tcc agt gac cct gaa atc     2381
 Gln Arg Val Val Pro Ala Leu Ile Thr Leu Ser Ser Asp Pro Glu Ile
                 650                 655                 660

 tct gtc agg att gcc aca att cca gcc ttt ggc act att atg gaa aca     2429
 Ser Val Arg Ile Ala Thr Ile Pro Ala Phe Gly Thr Ile Met Glu Thr
             665                 670                 675

 gta att caa aga gag ttg ctg gaa aga gtg aaa atg cag ttg gct tct     2477
 Val Ile Gln Arg Glu Leu Leu Glu Arg Val Lys Met Gln Leu Ala Ser
         680                 685                 690

 ttc ctg gaa gat cct cag tat caa gac caa cat tct ttg cat aca gag     2525
 Phe Leu Glu Asp Pro Gln Tyr Gln Asp Gln His Ser Leu His Thr Glu
     695                 700                 705

 atc ata aaa aca ttt ggt aga gtt ggc cct aac gca gaa ccc agg ttc     2573
 Ile Ile Lys Thr Phe Gly Arg Val Gly Pro Asn Ala Glu Pro Arg Phe
 710                 715                 720                 725

 cga gat gag ttt gtt ata cca cat ttg cat aag tta gcc ttg gtg aac     2621
 Arg Asp Glu Phe Val Ile Pro His Leu His Lys Leu Ala Leu Val Asn
                 730                 735                 740

 aac tta cag att gtg gat tct aaa aga ctg gac att gct acg cat ctt     2669
 Asn Leu Gln Ile Val Asp Ser Lys Arg Leu Asp Ile Ala Thr His Leu
             745                 750                 755

 ttt gaa gcc tac agt gca ctt tcc tgt tgt ttc att tca gag gat tta     2717
 Phe Glu Ala Tyr Ser Ala Leu Ser Cys Cys Phe Ile Ser Glu Asp Leu
         760                 765                 770

 atg gtt aat cac ttt tta cct ggt ctc aga tgt tta cgg act gac atg     2765
 Met Val Asn His Phe Leu Pro Gly Leu Arg Cys Leu Arg Thr Asp Met
     775                 780                 785

 gaa cat ctc tct cca gag cat gag gtt att tta agt tcc atg ata aaa     2813
 Glu His Leu Ser Pro Glu His Glu Val Ile Leu Ser Ser Met Ile Lys
 790                 795                 800                 805

 gaa tgt gaa caa aaa gtt gaa aac aag acc gtc caa gag cct caa ggc     2861
 Glu Cys Glu Gln Lys Val Glu Asn Lys Thr Val Gln Glu Pro Gln Gly
                 810                 815                 820

 tca atg tca att gct gca agc tta gtg agt gaa gat aca aag acc aag     2909
 Ser Met Ser Ile Ala Ala Ser Leu Val Ser Glu Asp Thr Lys Thr Lys
             825                 830                 835

 ttt ttg aac aaa atg ggc cag ttg aca aca tca ggt gcc atg ttg gcc     2957
 Phe Leu Asn Lys Met Gly Gln Leu Thr Thr Ser Gly Ala Met Leu Ala
         840                 845                 850

 aat gta ttt cag aga aag aag tag aagcaggaaa gaagccccca gtaaacacta    3011
 Asn Val Phe Gln Arg Lys Lys 
     855                 860

 agatggacct caagccgact ggttccttgt acttgaagta cttgcctttt ttgtttcctc   3071

 agttttatgt tcttgcatta taattttatc ctaacctcca aagatatttg cactgctttt   3131

 aattactgct gtatatttgt tgattttgga gttacaactg tggtgataga aaattgagtt   3191

 gatggtctgt accaagtccc ttgtctatgt tcttgtcttt cagaataatt tttatataaa   3251

 tatatatata gtgaagaagt tttttttaat ttttggatgg gatattcgca aatatctgta   3311

 ttatacacta agctattaca atggtactta aaataatgta aatttgaagt cattgttata   3371

 aaataataaa gtggagatta cttaagtatt taaattatga aagaataatg cagacttttt   3431

 attgtttctt aactgactag aaagagccac cagcattact ctgtgccttt tggacatcag   3491

 tttgtgtgtt ctgtaggaat tgtgtgcatt ccattcacac agtatttctt taggatgctg   3551

 tgatgatttg aattacaaat cctacagtca atagctaaag acgaaacctt catttcagaa   3611

 ctctcatgaa tattctttaa gtgctattta aacctcccca gcacttagat gcatataatg   3671

 gacttacctg aggaaagaca gcacataggc atggggagag gtaaccaagg tgaattttac   3731

 aaactggtgt atagtagatt taaatgctca aaaataaatg taactgagaa gagttaataa   3791

 ttgtgagatt tttcccaaat tgagatacag aagaaaatat agtttgaatc tgaaatttaa   3851

 cacttattta tgtaaaacat tttatttaag atattttcta atgattttaa ttttagagag   3911

 taccttttca ttctgtgtgt tacagagaag tactgaaaag ttaaggacac ttgggggcta   3971

 cttttttccc tctaaactaa aaaagacatt ggctgaatta taactagtta gttatcacct   4031

 cgtcccttaa agtcagtgac ctcctgtgtt tgatgtatat tacatagagt cttaagtcag   4091

 tgtacagttc cactggaatt tgacagttgt ctctacagtc atgcaactcg aagtagaaaa   4151

 gagtgctgga cataggaagg gggtgcttgg tttgaggggt taatgtgagg cctttttgaa   4211

 aaatgaatat tttgataaaa agaattcttg ttttagcaca gttgatgcac ataagtgatt   4271

 ctcatatttg ttgtataaac tggtttaata catttggaac atagttggat tacattcatt   4331

 tcctgggaaa gctagcttac catacattca agtttataaa acaatttgcc ataggcaaag   4391

 ccatttaaaa agttcattct gaaattattt catttaccta cagtgaaata attgtgaact   4451

 aagtagtctt tctgaaaact gttgggttct aggcattcct gagaaattga aagtggctac   4511

 ctttcatgtc aaaaatgttg atctattata aataaaatgt ttttgcatat gtttttgaaa   4571

 aaaaaaaaa                                                           4580




      <210> 274
      <211> 1890
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (78)..(1757)

      <400> 274
 cggacgcgtg ggcggacgcg tgggcgagtc cggccgggca gtagaggaaa ttgcggtagt     60

 gaccctcggg cctcgcc   atg aag agc cgc ttt agc acc att gac ctc cgc     110
                      Met Lys Ser Arg Phe Ser Thr Ile Asp Leu Arg
                        1               5                  10

 gcc gta ctc gcg gag ctg aat gct agc ttg cta gga atg aga gta aac      158
 Ala Val Leu Ala Glu Leu Asn Ala Ser Leu Leu Gly Met Arg Val Asn
              15                  20                  25

 aat gtt tat gat gtg gat aat aag aca tac ctt att cgt ctt caa aaa      206
 Asn Val Tyr Asp Val Asp Asn Lys Thr Tyr Leu Ile Arg Leu Gln Lys
          30                  35                  40

 ccg gac ttt aaa gct aca ctt tta ctt gaa tct ggc ata cga att cat      254
 Pro Asp Phe Lys Ala Thr Leu Leu Leu Glu Ser Gly Ile Arg Ile His
      45                  50                  55

 aca aca gaa ttt gag tgg cct aag aat atg atg ccg tct agt ttt gcc      302
 Thr Thr Glu Phe Glu Trp Pro Lys Asn Met Met Pro Ser Ser Phe Ala
  60                  65                  70                  75

 atg aag tgc cga aaa cat ttg aag agt cgg aga tta gtc agt gca aaa      350
 Met Lys Cys Arg Lys His Leu Lys Ser Arg Arg Leu Val Ser Ala Lys
                  80                  85                  90

 cag ctt ggt gtg gat aga att gta gat ttt caa ttt gga agt gat gaa      398
 Gln Leu Gly Val Asp Arg Ile Val Asp Phe Gln Phe Gly Ser Asp Glu
              95                 100                 105

 gct gct tac cat tta atc att gag ctc tat gat agg ggg aac att gtt      446
 Ala Ala Tyr His Leu Ile Ile Glu Leu Tyr Asp Arg Gly Asn Ile Val
         110                 115                 120

 ctt aca gat tat gag tac gta att tta aat att cta agg ttt cga act      494
 Leu Thr Asp Tyr Glu Tyr Val Ile Leu Asn Ile Leu Arg Phe Arg Thr
     125                 130                 135

 gat gag gca gat gat gtt aaa ttt gct gtt cgt gaa cgc tat cca ctt      542
 Asp Glu Ala Asp Asp Val Lys Phe Ala Val Arg Glu Arg Tyr Pro Leu
 140                 145                 150                 155

 gat cat gct aga gct gct gaa cct ttg ctt act ttg gaa agg ttg act      590
 Asp His Ala Arg Ala Ala Glu Pro Leu Leu Thr Leu Glu Arg Leu Thr
                 160                 165                 170

 gaa ata gta gcc agc gca cct aag ggt gaa cta ctg aag agg gtg ctt      638
 Glu Ile Val Ala Ser Ala Pro Lys Gly Glu Leu Leu Lys Arg Val Leu
             175                 180                 185

 aac cca tta ctt ccc tat gga cca gct ctc att gaa cac tgt ctt tta      686
 Asn Pro Leu Leu Pro Tyr Gly Pro Ala Leu Ile Glu His Cys Leu Leu
         190                 195                 200

 gaa aat gga ttc tcg ggt aat gtc aaa gtg gat gaa aaa ctt gaa act      734
 Glu Asn Gly Phe Ser Gly Asn Val Lys Val Asp Glu Lys Leu Glu Thr
     205                 210                 215

 aaa gat att gaa aaa gta ctt gtt tct ctg cag aaa gca gaa gac tat      782
 Lys Asp Ile Glu Lys Val Leu Val Ser Leu Gln Lys Ala Glu Asp Tyr
 220                 225                 230                 235

 atg aaa aca aca tcc aac ttc agt ggg aag gga tat atc att cag aaa      830
 Met Lys Thr Thr Ser Asn Phe Ser Gly Lys Gly Tyr Ile Ile Gln Lys
                 240                 245                 250

 aga gaa ata aaa cca tgc ttg gaa gca gat aaa cca gtt gaa gac ata      878
 Arg Glu Ile Lys Pro Cys Leu Glu Ala Asp Lys Pro Val Glu Asp Ile
             255                 260                 265

 ctg acg tat gag gaa ttt cat cct ttc ttg ttt tct caa cat tca caa      926
 Leu Thr Tyr Glu Glu Phe His Pro Phe Leu Phe Ser Gln His Ser Gln
         270                 275                 280

 tgt cca tat ata gaa ttt gaa tca ttt gac aag gcg gtg gat gaa ttt      974
 Cys Pro Tyr Ile Glu Phe Glu Ser Phe Asp Lys Ala Val Asp Glu Phe
     285                 290                 295

 tat tcc aag ata gaa ggc cag aaa att gac tta aaa gct tta caa cag     1022
 Tyr Ser Lys Ile Glu Gly Gln Lys Ile Asp Leu Lys Ala Leu Gln Gln
 300                 305                 310                 315

 gaa aag caa gca ttg aag aaa tta gat aat gtt cga aag gat cac gaa     1070
 Glu Lys Gln Ala Leu Lys Lys Leu Asp Asn Val Arg Lys Asp His Glu
                 320                 325                 330

 aac aga ttg gaa gct ctt cag cag gct cag gaa ata gac aaa ctg aaa     1118
 Asn Arg Leu Glu Ala Leu Gln Gln Ala Gln Glu Ile Asp Lys Leu Lys
             335                 340                 345

 gga gag ctc ata gaa atg aac cta caa ata gtt gac aga gcc att cag     1166
 Gly Glu Leu Ile Glu Met Asn Leu Gln Ile Val Asp Arg Ala Ile Gln
         350                 355                 360

 gta gtt cga agt gct tta gct aac cag ata gat tgg aca gaa att ggg     1214
 Val Val Arg Ser Ala Leu Ala Asn Gln Ile Asp Trp Thr Glu Ile Gly
     365                 370                 375

 tta att gtg aaa gaa gcc cag gct caa gga gac cct gtt gca agt gca     1262
 Leu Ile Val Lys Glu Ala Gln Ala Gln Gly Asp Pro Val Ala Ser Ala
 380                 385                 390                 395

 atc aaa gaa tta aaa cta caa aca aac cat gtt aca atg ctg cta aga     1310
 Ile Lys Glu Leu Lys Leu Gln Thr Asn His Val Thr Met Leu Leu Arg
                 400                 405                 410

 aat cca tac ttg tta tca gag gag gaa gat gat gat gtt gat ggt gac     1358
 Asn Pro Tyr Leu Leu Ser Glu Glu Glu Asp Asp Asp Val Asp Gly Asp
             415                 420                 425

 gtc aat gtt gag aaa aat gaa act gaa cca cca aaa gga aaa aag aaa     1406
 Val Asn Val Glu Lys Asn Glu Thr Glu Pro Pro Lys Gly Lys Lys Lys
         430                 435                 440

 aaa caa aag aat aaa cag ctg cag aag cct cag aaa aat aag ccc tta     1454
 Lys Gln Lys Asn Lys Gln Leu Gln Lys Pro Gln Lys Asn Lys Pro Leu
     445                 450                 455

 ctt gta gat gtt gat ctc agc ttg tca gca tat gcc aat gcc aaa aag     1502
 Leu Val Asp Val Asp Leu Ser Leu Ser Ala Tyr Ala Asn Ala Lys Lys
 460                 465                 470                 475

 tat tat gat cac aag aga tat gct gct aag aaa aca caa aag act gtt     1550
 Tyr Tyr Asp His Lys Arg Tyr Ala Ala Lys Lys Thr Gln Lys Thr Val
                 480                 485                 490

 gaa gct gct gag aag gca ttc aag tca gca gaa aag aaa aca aag caa     1598
 Glu Ala Ala Glu Lys Ala Phe Lys Ser Ala Glu Lys Lys Thr Lys Gln
             495                 500                 505

 aca tta aaa gaa gtt cag act gtt acc tct att caa aaa gca aga aaa     1646
 Thr Leu Lys Glu Val Gln Thr Val Thr Ser Ile Gln Lys Ala Arg Lys
         510                 515                 520

 gta tat tgg ttg act gaa ata gta gcc agc gca cct aag ggt gaa cta     1694
 Val Tyr Trp Leu Thr Glu Ile Val Ala Ser Ala Pro Lys Gly Glu Leu
     525                 530                 535

 ctg aag agg gtg ctt acc cat tac ttc cct atg gac cag ctc tca ttg     1742
 Leu Lys Arg Val Leu Thr His Tyr Phe Pro Met Asp Gln Leu Ser Leu
 540                 545                 550                 555

 aac act gtc ttt tag aaaatggatt ctcgggtaat gtcaaagtgg atgaaaaact     1797
 Asn Thr Val Phe 


 tgaaactaaa gatattgaaa gagtacttgt ttctctgcag aaagcagaag actatatgaa   1857

 aacacatcca cttcagtgga agggattatc atg                                1890




      <210> 275
      <211> 3038
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1557)

      <400> 275
  atg gca gag aca agt ctg tta gag gct ggg gcc tct gca gcc tct aca      48
  Met Ala Glu Thr Ser Leu Leu Glu Ala Gly Ala Ser Ala Ala Ser Thr
    1               5                  10                  15

 gct gcg gct ttg gag aac tta cag gtg gag gcg agc tgc tct gtg tgc       96
 Ala Ala Ala Leu Glu Asn Leu Gln Val Glu Ala Ser Cys Ser Val Cys
              20                  25                  30

 ctg gag tat ctg aag gaa cct gtc atc att gag tgt ggg cac aac ttc      144
 Leu Glu Tyr Leu Lys Glu Pro Val Ile Ile Glu Cys Gly His Asn Phe
          35                  40                  45

 tgc aaa gct tgc atc acc cgc tgg tgg gag gac cta gag agg gac ttc      192
 Cys Lys Ala Cys Ile Thr Arg Trp Trp Glu Asp Leu Glu Arg Asp Phe
      50                  55                  60

 cct tgt cct gtc tgt cga aag aca tcc cgc tac cgc agt ctc cga cct      240
 Pro Cys Pro Val Cys Arg Lys Thr Ser Arg Tyr Arg Ser Leu Arg Pro
  65                  70                  75                  80

 aat cgg caa cta ggc agt atg gtg gaa att gcc aag cag ctc cag gcc      288
 Asn Arg Gln Leu Gly Ser Met Val Glu Ile Ala Lys Gln Leu Gln Ala
                  85                  90                  95

 gtc aag cgg aag atc cgg gat gag agc ctc tgc ccc caa cac cat gag      336
 Val Lys Arg Lys Ile Arg Asp Glu Ser Leu Cys Pro Gln His His Glu
             100                 105                 110

 gcc ctc agc ctt ttc tgt tat gag gac cag gag gct gta tgc ttg ata      384
 Ala Leu Ser Leu Phe Cys Tyr Glu Asp Gln Glu Ala Val Cys Leu Ile
         115                 120                 125

 tgt gca att tcc cac acc cac cgg ccc cac acc gtt gtg cca ctg gac      432
 Cys Ala Ile Ser His Thr His Arg Pro His Thr Val Val Pro Leu Asp
     130                 135                 140

 gat gct aca cag gag tac aag gaa aaa ctg cag aag tgt ctg gag ccc      480
 Asp Ala Thr Gln Glu Tyr Lys Glu Lys Leu Gln Lys Cys Leu Glu Pro
 145                 150                 155                 160

 ctg gaa cag aag ctg cag gag atc act cgc tgc aag tcc tct gag gag      528
 Leu Glu Gln Lys Leu Gln Glu Ile Thr Arg Cys Lys Ser Ser Glu Glu
                 165                 170                 175

 aag aag cct ggt gag ctc aag aga cta gtg gaa agt cgc cga cag cag      576
 Lys Lys Pro Gly Glu Leu Lys Arg Leu Val Glu Ser Arg Arg Gln Gln
             180                 185                 190

 atc ttg agg gag ttt gaa gag ctt cat agg cgg ctg gat gaa gag cag      624
 Ile Leu Arg Glu Phe Glu Glu Leu His Arg Arg Leu Asp Glu Glu Gln
         195                 200                 205

 cag gtg ttg ctt tca cga ctg gaa gaa gag gaa cag gac att ctg cag      672
 Gln Val Leu Leu Ser Arg Leu Glu Glu Glu Glu Gln Asp Ile Leu Gln
     210                 215                 220

 cga ctc cga gaa aat gct gct cac ctt ggg gac aag cgc cgg gac ctg      720
 Arg Leu Arg Glu Asn Ala Ala His Leu Gly Asp Lys Arg Arg Asp Leu
 225                 230                 235                 240

 gcc cac ttg gct gcc gag gtg gag ggc aag tgc tta cag tca ggc ttc      768
 Ala His Leu Ala Ala Glu Val Glu Gly Lys Cys Leu Gln Ser Gly Phe
                 245                 250                 255

 gag atg ctt aag gat gtc aaa agt acc ctg gaa aag aat att cct aga      816
 Glu Met Leu Lys Asp Val Lys Ser Thr Leu Glu Lys Asn Ile Pro Arg
             260                 265                 270

 aag ttc gga ggc tca ctc tca acg atc tgt cca cgg gat cat aag gct      864
 Lys Phe Gly Gly Ser Leu Ser Thr Ile Cys Pro Arg Asp His Lys Ala
         275                 280                 285

 ctc ctt gga tta gta aaa gaa atc aac aga tgt gaa aag gtg aag acc      912
 Leu Leu Gly Leu Val Lys Glu Ile Asn Arg Cys Glu Lys Val Lys Thr
     290                 295                 300

 atg gag gtg act tca gta tcc ata gag ctg gaa aag aac ttc agc aat      960
 Met Glu Val Thr Ser Val Ser Ile Glu Leu Glu Lys Asn Phe Ser Asn
 305                 310                 315                 320

 ttt ccc cga cag tac ttt gcc cta agg aaa atc ctt aaa cag cta att     1008
 Phe Pro Arg Gln Tyr Phe Ala Leu Arg Lys Ile Leu Lys Gln Leu Ile
                 325                 330                 335

 gcg gat gtg acc ctg gac cct gag aca gct cat cct aac cta gtc ctg     1056
 Ala Asp Val Thr Leu Asp Pro Glu Thr Ala His Pro Asn Leu Val Leu
             340                 345                 350

 tca gag gat cgt aag agc gtc aag ttc gtg gag aca aga ctc cgg gat     1104
 Ser Glu Asp Arg Lys Ser Val Lys Phe Val Glu Thr Arg Leu Arg Asp
         355                 360                 365

 ctc cct gac aca cca agg cgt ttc acc ttc tac cct tgc gtc ctg gct     1152
 Leu Pro Asp Thr Pro Arg Arg Phe Thr Phe Tyr Pro Cys Val Leu Ala
     370                 375                 380

 act gag ggt ttc acc tca ggt cga cac tac tgg gag gtg gag gtg ggc     1200
 Thr Glu Gly Phe Thr Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly
 385                 390                 395                 400

 gac aag acc cac tgg gca gtg ggt gta tgc cgg gac tcc gtg agc cga     1248
 Asp Lys Thr His Trp Ala Val Gly Val Cys Arg Asp Ser Val Ser Arg
                 405                 410                 415

 aag ggc gag ttg act cca ctc cct gag act ggc tac tgg cgg gtg cgg     1296
 Lys Gly Glu Leu Thr Pro Leu Pro Glu Thr Gly Tyr Trp Arg Val Arg
             420                 425                 430

 cta tgg aat ggg gac aaa tat gca gcc acc acc aca cct ttt acc cct     1344
 Leu Trp Asn Gly Asp Lys Tyr Ala Ala Thr Thr Thr Pro Phe Thr Pro
         435                 440                 445

 ttg cac atc aag gtg aaa ccc aag cgg gta ggc ata ttc cta gac tat     1392
 Leu His Ile Lys Val Lys Pro Lys Arg Val Gly Ile Phe Leu Asp Tyr
     450                 455                 460

 gag gcc ggc aca ctg tct ttc tac aat gtc aca gac cgc tct cat atc     1440
 Glu Ala Gly Thr Leu Ser Phe Tyr Asn Val Thr Asp Arg Ser His Ile
 465                 470                 475                 480

 tac acc ttc act gat act ttt act gag aaa ctt tgg ccc ctc ttc tac     1488
 Tyr Thr Phe Thr Asp Thr Phe Thr Glu Lys Leu Trp Pro Leu Phe Tyr
                 485                 490                 495

 cca ggc atc cgg gct gga cgg aag aat gct gca cca ctt acc atc agg     1536
 Pro Gly Ile Arg Ala Gly Arg Lys Asn Ala Ala Pro Leu Thr Ile Arg
             500                 505                 510

 ccc cca aca gat tgg gag tga ca ggttgggatg tgggaatgac tggggtgagg     1589
 Pro Pro Thr Asp Trp Glu 
         515

 cagggtcaag cgctacgggc ctccttcccg tgtcctgctg gaacgtcttc gtgtccacct   1649

 gggtccagtc ctgaatcatc ttggagaaac accttggttt ctaggatggt tttgtgtgga   1709

 gggggaggta ggactgggct ggatgagaga gcacagctgt gacttcctcc taactgtcag   1769

 ggtggggagc tggttcccag aggattgtct accctgaagt ccatcaggtt ttctgttgca   1829

 caaggacggg tcaggaagga aggagaggct tttccagaaa caaaaaatct gtgagggtct   1889

 gacttgctca aaccagagga ggaaacagaa acccctgcac atctttttag ggggttcttt   1949

 gacccaggat agtcttgctt cttgaggtag atcatagggg tctgtgtacc tctgaattca   2009

 tgagagatga atgacagatg ctctcatggg tctagatatt gaggagtttt tctgagggca   2069

 gagattggac atcaacaagg ctagaagggt cagggaagtg ggctaaagga acagattcct   2129

 agagattaat gaagaggagg gaggtttctt tggtcttcta ttccaagggt aaggttgcga   2189

 ttatgggtaa gattggccag aggtaggaat gtggggagaa ggagaggctg aaaagaaagc   2249

 agaggagaac ccaggtccct gcctcagcct tcagcagagt tggcttattg cctgcctcta   2309

 taccaataag tcagtcacct tgctcctctc cagaggcaaa gtggaagaga tcctgcaaga   2369

 cacatctatc ctttcacagt gttcccaagg gaacttggaa aggagagtca ggtattagag   2429

 gaaagagaag ggtatttgta tacaaagccc tggccttaaa gaatgttact tagtagctac   2489

 tcccaaattg tcagccttct tacctggcca aggtgtccaa gccagaaagg aaaaaaggtt   2549

 atggagtctt tctcacccta aggacagggt ggaagagggt ggtatatagg gaagggccag   2609

 ataggcaact tcatttggct tgtgtgcatc tggcctggaa ctggtgttaa gccaggcttt   2669

 tgcttgtttg ttgccatccc tcaccctttg ccatttccct tttcagagaa tgtaaatgat   2729

 tttcatgtta ggccaaaata aacaacttat agggtacata tgttgtcata aaaggtaaaa   2789

 gtgatgcatg ccaaaccaaa ctaaaccaat ttggattatc tgctattcgg gtaatcttca   2849

 cagaaatgac tgagagaaga atctgcagtt tactgagggc atttcagttc ctcctaccac   2909

 ctcaacagga ctttgtccag actctcctcc tcttaccttt gtgccttgac tgtggttctt   2969

 tgtggcaaga tactttggtt ggttaaaata atatggaaca aaggatccac tgaagtgaaa   3029

 aaaaaaaaa                                                           3038




      <210> 276
      <211> 4173
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1106)..(2617)

      <220>
      <221> misc_feature
      <222> (1)...(4173)
      <223> n = a,t,c or g

      <400> 276
 attcaagtct gagatacaga taagtattgc tttggaaacc gatacaaagc caccagtgga     60

 tagctttaaa gcaaaggggg ctccccctcg agatggaaaa gtacctgcca tcctggctgg    120

 acttgacccc agggacattg tggctgtgct gaatgaagag ggaggctacc atcagattgg    180

 accagcagaa tactgtactg actcctttat tatgtcagtg accatagcat ttgctaccca    240

 gttggaacag ttaattccat gtaccatgaa acttccagaa agacagcctg agtttttctt    300

 ttactactct ttactgggaa atgatgttac aaatgaaccc ttcaatgatt taatcaaccc    360

 aaactttgag ccagagagag catcagttcg catccgtagc agtgtagaaa ttcttcgtgt    420

 ttacctggct cttcagtcta aactgcagat tcacctctgc tgtggagacc agtcacttgg    480

 aagtacagaa atacctttaa ctggattact taaaaagggc agtacagaaa tcaaccagca    540

 cccagtcaca gtcgaaggtg cttttaccct tgaccctcca aacagagcca aacagaagct    600

 tgcacctatt cctgtggagc tagccccaac tgtgggagtg tctgtgnctc tgcagagaga    660

 aggcatagac tcccagtctt taattgaatt aaagacccag aatgaacatg agccagagca    720

 ttcaaagaag aaagttttaa cccccataaa ggagaagaca cttactgggc caaaatcacc    780

 aacagtgtcc cctgttccat ctcacaacca gtcacctcca acaaaagatg atgcaacaga    840

 aagtgaagtg gaaagtttac agtatgataa ggacaccaaa ccaaatccaa aagccagttc    900

 ttctgtacct gcttcactgg cccagctagt gactacatcc aatgcttcag aagtagcttc    960

 aggacagaag attgctgtac cagcaacatc acatcatttt tgcttttcaa tagacttaag   1020

 gagtatacat gccttggaga ttggttttcc aatcaactgt atattaaggt actcatatcc   1080

 attctttgga agtgcagctc ctatt  atg act aat cct cct gta gaa gtt cgg    1132
                              Met Thr Asn Pro Pro Val Glu Val Arg
                                1               5

 aaa aac atg gaa gtt ttt ctt ccc cag tct tac tgt gca ttt gat ttt     1180
 Lys Asn Met Glu Val Phe Leu Pro Gln Ser Tyr Cys Ala Phe Asp Phe
  10                  15                  20                  25

 gca act atg cct cat cag ctg caa gac acc ttc tta agg att cca tta     1228
 Ala Thr Met Pro His Gln Leu Gln Asp Thr Phe Leu Arg Ile Pro Leu
                  30                  35                  40

 ctg gtt gaa cta tgg cac aag gat aaa atg agt aaa gat tta ctt ctg     1276
 Leu Val Glu Leu Trp His Lys Asp Lys Met Ser Lys Asp Leu Leu Leu
              45                  50                  55

 gga att gcg aga atc cag ctt tct aac atc ttg tct tca gaa aaa act     1324
 Gly Ile Ala Arg Ile Gln Leu Ser Asn Ile Leu Ser Ser Glu Lys Thr
          60                  65                  70

 cgt ttt tta ggt tct aat ggt gaa cag tgt tgg cgt caa act tac agt     1372
 Arg Phe Leu Gly Ser Asn Gly Glu Gln Cys Trp Arg Gln Thr Tyr Ser
      75                  80                  85

 gaa agt gtg cct gtt ata gca gca caa gga tca aat aac agg ata gca     1420
 Glu Ser Val Pro Val Ile Ala Ala Gln Gly Ser Asn Asn Arg Ile Ala
  90                  95                 100                 105

 gat ctt tct tac aca gtg act cta gaa gat tat gga cta gta aaa atg     1468
 Asp Leu Ser Tyr Thr Val Thr Leu Glu Asp Tyr Gly Leu Val Lys Met
                 110                 115                 120

 cgt gag att ttt atc tct gat tca tct cag ggt gta tct gcc gta cag     1516
 Arg Glu Ile Phe Ile Ser Asp Ser Ser Gln Gly Val Ser Ala Val Gln
             125                 130                 135

 caa aag ccg tct tct ctt cct cca gca cct tgt cct tca gag atc cag     1564
 Gln Lys Pro Ser Ser Leu Pro Pro Ala Pro Cys Pro Ser Glu Ile Gln
         140                 145                 150

 aca gag cct cgt gaa acg tta gaa tac aaa gca gca ctt gag cta gaa     1612
 Thr Glu Pro Arg Glu Thr Leu Glu Tyr Lys Ala Ala Leu Glu Leu Glu
     155                 160                 165

 atg tgg aag gag atg caa gaa gat ata ttt gaa aat cag ctg aag cag     1660
 Met Trp Lys Glu Met Gln Glu Asp Ile Phe Glu Asn Gln Leu Lys Gln
 170                 175                 180                 185

 aaa gaa ctg gct cat atg cag gct ctt gca gag gaa tgg aag aaa agg     1708
 Lys Glu Leu Ala His Met Gln Ala Leu Ala Glu Glu Trp Lys Lys Arg
                 190                 195                 200

 gac cga gaa aga gaa tca cta gta aag aaa aag gta ata act tgt gta     1756
 Asp Arg Glu Arg Glu Ser Leu Val Lys Lys Lys Val Ile Thr Cys Val
             205                 210                 215

 aaa gtg gct gaa tat act att cta gaa gga aaa ctt caa aaa act cta     1804
 Lys Val Ala Glu Tyr Thr Ile Leu Glu Gly Lys Leu Gln Lys Thr Leu
         220                 225                 230

 att gac ttg gag aag cga gag cag cag ctt gct agt gtg gaa tca gag     1852
 Ile Asp Leu Glu Lys Arg Glu Gln Gln Leu Ala Ser Val Glu Ser Glu
     235                 240                 245

 ctt caa aga gaa aaa aag gaa ctg caa tca gaa cgt cag cgg aac ctg     1900
 Leu Gln Arg Glu Lys Lys Glu Leu Gln Ser Glu Arg Gln Arg Asn Leu
 250                 255                 260                 265

 caa gaa ctg cag gac tct atc cgt agg gcc aaa gag gac tgt att cac     1948
 Gln Glu Leu Gln Asp Ser Ile Arg Arg Ala Lys Glu Asp Cys Ile His
                 270                 275                 280

 caa gta gaa cta gaa agg tta aaa atc aaa cag ctc gaa gag gat aaa     1996
 Gln Val Glu Leu Glu Arg Leu Lys Ile Lys Gln Leu Glu Glu Asp Lys
             285                 290                 295

 cac cgc ctt cag caa cag ctt aat gat gct gaa aat aag tat aag att     2044
 His Arg Leu Gln Gln Gln Leu Asn Asp Ala Glu Asn Lys Tyr Lys Ile
         300                 305                 310

 ttg gaa aaa gag ttc caa cag ttc aag gac cag caa aac aac aaa cca     2092
 Leu Glu Lys Glu Phe Gln Gln Phe Lys Asp Gln Gln Asn Asn Lys Pro
     315                 320                 325

 gaa atc cgt cta cag tct gaa ata aat ctt ctc acc ttg gaa aag gtt     2140
 Glu Ile Arg Leu Gln Ser Glu Ile Asn Leu Leu Thr Leu Glu Lys Val
 330                 335                 340                 345

 gaa ctt gaa aga aag ttg gaa tct gca act aag tct aaa ctg cat tac     2188
 Glu Leu Glu Arg Lys Leu Glu Ser Ala Thr Lys Ser Lys Leu His Tyr
                 350                 355                 360

 aag cag cag tgg gga cga gct ttg aaa gaa ctt gcc aga ctt aaa cag     2236
 Lys Gln Gln Trp Gly Arg Ala Leu Lys Glu Leu Ala Arg Leu Lys Gln
             365                 370                 375

 agg gag caa gaa agt caa atg gct cgt ctt aaa aaa cag cag gaa gaa     2284
 Arg Glu Gln Glu Ser Gln Met Ala Arg Leu Lys Lys Gln Gln Glu Glu
         380                 385                 390

 ttg gaa cag atg aga cta cgt tac ctt gcc gct gag gaa aaa gat aca     2332
 Leu Glu Gln Met Arg Leu Arg Tyr Leu Ala Ala Glu Glu Lys Asp Thr
     395                 400                 405

 gta aaa acc gag cga caa gaa ttg ttg gat ata aga aat gaa ttg aac     2380
 Val Lys Thr Glu Arg Gln Glu Leu Leu Asp Ile Arg Asn Glu Leu Asn
 410                 415                 420                 425

 agg tta agg caa caa gag caa aaa caa tac cag gat tcc aca gag att     2428
 Arg Leu Arg Gln Gln Glu Gln Lys Gln Tyr Gln Asp Ser Thr Glu Ile
                 430                 435                 440

 gca agt gga aaa aag gat ggc ccc cat ggc agt gta ttg gaa gaa ggt     2476
 Ala Ser Gly Lys Lys Asp Gly Pro His Gly Ser Val Leu Glu Glu Gly
             445                 450                 455

 ttg gat gat tat ttg act cgc ctg ata gaa gaa agg gat act ttg atg     2524
 Leu Asp Asp Tyr Leu Thr Arg Leu Ile Glu Glu Arg Asp Thr Leu Met
         460                 465                 470

 aga acg ggt gtg tat aat cac gag gat cga ata ata agt gaa ctc gac     2572
 Arg Thr Gly Val Tyr Asn His Glu Asp Arg Ile Ile Ser Glu Leu Asp
     475                 480                 485

 cga cag atc aga gag att ttg gca aaa agc aat gcc agt aat taa taa     2620
 Arg Gln Ile Arg Glu Ile Leu Ala Lys Ser Asn Ala Ser Asn 
 490                 495                 500

 catttggaaa agctttatag agactctaag tctaaatttt aatttctttg taaaaccctc   2680

 aaaagtgagg aaaatggatg ttttaaaatg gtattttcaa ttttttataa gcaaaatttt   2740

 gtatgttatt gtatagtatt tatttgatct tatttacttt atgctacctc tcccacactg   2800

 gttttatttg taatttgcat ttatatactc attttaaatg acttttcagt gtttttcata   2860

 gtttataatc tgatggctaa ctaactttca aaacagcttt taactaagtt tgttgtagga   2920

 gaaatgactg cggtaatttc cagttctata atgtttcatg ttgagccaaa agagtatatc   2980

 ttgcacttta aaaacactgc gtcctattcc atttgaatgt aaattcttaa aagttgagac   3040

 caattgtaac cagtttaact cattttagat gacctttttt tcttataata tttgcaagtg   3100

 acaagtttga aaacaaagca agatcagtgc agagaagcca catgacatgt tgggtgacag   3160

 attggtcatt tatttaaata aagttaatac agattaaatt tgtttcaaga gctattgaat   3220

 tttcaaattt tcagtgtatt tataactttt aagaacatga agtattagct taatatagtt   3280

 ttctctgttg gtttcttcct caagtttgca ttgttttctt ttgttaaaat tagagatttc   3340

 tttttatttt ccagttatag taatactagc tgtcagctta aaccctctgt aatagaacat   3400

 ggaaacagac acataaagac attagctgaa aaaatagagt gaaaatcaac tattttttac   3460

 tcccgctaat ttcaatcaat cgttttcaaa agcgcacgag attcactcat tggatttatg   3520

 cagtgccctg tctgtataaa aactcttaag agttccttta tatcatattc ttcagagcca   3580

 acatttgtcc tcaaagcaac gtttcccacc tccttttact gagtactgaa aaagttttag   3640

 caaagtcaca gattaggttg aatttcaaaa tatatgtact ttaaaaagtt ctgatttcca   3700

 aatataataa agttaaaatt aagtatatac tttaggaagt taccaataac ttccatcaaa   3760

 gcagagtagg atatatggta acattaattt tcggtcattt caaatgaggt atatttctta   3820

 ttagggaaat taaagtccct atatttatta tatatttttt ccttattaac agagtattaa   3880

 tctagtaaaa aataacccag cagtaaataa taaagaaatt actgaatgag aggataatga   3940

 atctgaatca tagcaggaat ttgcaatatt aattatggtt agctattttt ctctcattga   4000

 tttttgtgcc acttgaatgg aacagaagca agccttatgt tttggaaggt ctgcggtaaa   4060

 atgctgtgac tgtttacttt caattgcatt gtgtgttgcc tgtgactgct ttcaaacgct   4120

 agagggggcc tctgatttaa agaaataaaa aggacttttc taaaaaaaaa aaa          4173




      <210> 277
      <211> 2296
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (404)..(2242)

      <400> 277
 atgaatatag tgacaaccag tcttcaggta ggcttcggag gcgagcgaag ggcgggacca     60

 aggccagagc ccgacagtta cgccactcac acttgcggaa gagttaacgg gacagtggtg    120

 caggccaatc gcaaccagtc ctctggaggc agggagactg gggtggagac ttcggagact    180

 gcagttgcag ttgttccgtg taggctgttg ttgactctcg tatgaaagcc cacgcgatcc    240

 aagtgccctg caggttttgg tccagggaaa agttggtctc tgcagatgac tgtaaatgac    300

 tacctggagg tcgattaaag tgcggtactg cgggattcag ccgatttcct tcttcctctg    360

 actgcccgga aatatcagcc aaaggccagc gttctaagga cat  atg gaa ttg gct     415
                                                  Met Glu Leu Ala
                                                    1

 atg gat aat tca tat gct ttc aat caa cga agc aca tgt aat gga att      463
 Met Asp Asn Ser Tyr Ala Phe Asn Gln Arg Ser Thr Cys Asn Gly Ile
   5                  10                  15                  20

 cca tct gag aag aaa aac aac ttc ctt gta tca gaa gat cat gga caa      511
 Pro Ser Glu Lys Lys Asn Asn Phe Leu Val Ser Glu Asp His Gly Gln
                  25                  30                  35

 aaa atc tta agt gta cta cag aat ttt aga gaa caa aat gtc ttt tat      559
 Lys Ile Leu Ser Val Leu Gln Asn Phe Arg Glu Gln Asn Val Phe Tyr
              40                  45                  50

 gat ttc aaa ata att atg aaa gat gaa ata atc ccg tgt cat cgt tgt      607
 Asp Phe Lys Ile Ile Met Lys Asp Glu Ile Ile Pro Cys His Arg Cys
          55                  60                  65

 gtg tta gca gca tgc agt gac ttt ttc agg gct atg ttt gaa gta aac      655
 Val Leu Ala Ala Cys Ser Asp Phe Phe Arg Ala Met Phe Glu Val Asn
      70                  75                  80

 atg aaa gaa aga gat gat gga agt gtt acc att act aat ttg tcc tcc      703
 Met Lys Glu Arg Asp Asp Gly Ser Val Thr Ile Thr Asn Leu Ser Ser
  85                  90                  95                 100

 aag gca gta aaa gca ttt ctc gat tat gcc tat act gga aaa aca aaa      751
 Lys Ala Val Lys Ala Phe Leu Asp Tyr Ala Tyr Thr Gly Lys Thr Lys
                 105                 110                 115

 ata aca gat gat aat gtg gaa atg ttc ttc cag ttg tca tca ttt ctt      799
 Ile Thr Asp Asp Asn Val Glu Met Phe Phe Gln Leu Ser Ser Phe Leu
             120                 125                 130

 caa gtt tcc ttc cta tcc aaa gct tgc agt gac ttt tta ata aaa agt      847
 Gln Val Ser Phe Leu Ser Lys Ala Cys Ser Asp Phe Leu Ile Lys Ser
         135                 140                 145

 att aat ctt gtc aat tgt tta cag tta tta tct ata tca gat agc tat      895
 Ile Asn Leu Val Asn Cys Leu Gln Leu Leu Ser Ile Ser Asp Ser Tyr
     150                 155                 160

 ggc tcc acc agt ttg ttt gat cat gca tta cac ttt gta caa cat cac      943
 Gly Ser Thr Ser Leu Phe Asp His Ala Leu His Phe Val Gln His His
 165                 170                 175                 180

 ttt tct tta tta ttt aaa tcc agt gat ttc tta gag atg aat ttt gga      991
 Phe Ser Leu Leu Phe Lys Ser Ser Asp Phe Leu Glu Met Asn Phe Gly
                 185                 190                 195

 gta cta cag aaa tgt ctg gaa tca gat gaa tta aat gtt cct gaa gaa     1039
 Val Leu Gln Lys Cys Leu Glu Ser Asp Glu Leu Asn Val Pro Glu Glu
             200                 205                 210

 gaa atg gta ctg aaa gtt gtc ctt agt tgg act aaa cat aac tta gaa     1087
 Glu Met Val Leu Lys Val Val Leu Ser Trp Thr Lys His Asn Leu Glu
         215                 220                 225

 tca agg caa aag tat ctg cct cat ttg att gaa aaa gtg aga tta cat     1135
 Ser Arg Gln Lys Tyr Leu Pro His Leu Ile Glu Lys Val Arg Leu His
     230                 235                 240

 cag tta tct gag gag aca ctt cag gac tgt ctg ttc aat gaa gag agt     1183
 Gln Leu Ser Glu Glu Thr Leu Gln Asp Cys Leu Phe Asn Glu Glu Ser
 245                 250                 255                 260

 tta ctc aaa agc aca aac tgt ttt gac ata atc atg gat gca att aag     1231
 Leu Leu Lys Ser Thr Asn Cys Phe Asp Ile Ile Met Asp Ala Ile Lys
                 265                 270                 275

 tgt gtg caa ggt tct ggt gga ctc ttc cct gat gct cga cca tcc aca     1279
 Cys Val Gln Gly Ser Gly Gly Leu Phe Pro Asp Ala Arg Pro Ser Thr
             280                 285                 290

 act gag aaa tac ata ttc att cac aaa act gag gaa aat gga gaa aat     1327
 Thr Glu Lys Tyr Ile Phe Ile His Lys Thr Glu Glu Asn Gly Glu Asn
         295                 300                 305

 caa tat aca ttt tgc tat aac att aaa tct gat tca tgg aaa ata ctg     1375
 Gln Tyr Thr Phe Cys Tyr Asn Ile Lys Ser Asp Ser Trp Lys Ile Leu
     310                 315                 320

 ccg caa tca cac ctg att gat ttg cca gga tct agt ctt tcg agt tac     1423
 Pro Gln Ser His Leu Ile Asp Leu Pro Gly Ser Ser Leu Ser Ser Tyr
 325                 330                 335                 340

 gga gag aaa ata ttc ttg aca ggt ggt tgc aaa ggg aaa tgt tgt cga     1471
 Gly Glu Lys Ile Phe Leu Thr Gly Gly Cys Lys Gly Lys Cys Cys Arg
                 345                 350                 355

 acg gtt cga ctg cat att gcc gag tca tat cat gat gcc act gat caa     1519
 Thr Val Arg Leu His Ile Ala Glu Ser Tyr His Asp Ala Thr Asp Gln
             360                 365                 370

 acc tgg tgc tac tgt cca gtg aaa aat gat ttc ttc ttg gta tca act     1567
 Thr Trp Cys Tyr Cys Pro Val Lys Asn Asp Phe Phe Leu Val Ser Thr
         375                 380                 385

 atg aaa aca cca aga acc atg cat aca tca gtt atg gct ctc gat aga     1615
 Met Lys Thr Pro Arg Thr Met His Thr Ser Val Met Ala Leu Asp Arg
     390                 395                 400

 tta ttt gtc ata ggt gga aaa act aga gga tcc cgg gac att aaa agt     1663
 Leu Phe Val Ile Gly Gly Lys Thr Arg Gly Ser Arg Asp Ile Lys Ser
 405                 410                 415                 420

 ctc tta gat gtt gaa tct tac aat cct ctt tcc aaa gaa tgg ata tct     1711
 Leu Leu Asp Val Glu Ser Tyr Asn Pro Leu Ser Lys Glu Trp Ile Ser
                 425                 430                 435

 gtt agc cca tta ccc aga ggc ata tac tat cca gaa gca agc aca tgc     1759
 Val Ser Pro Leu Pro Arg Gly Ile Tyr Tyr Pro Glu Ala Ser Thr Cys
             440                 445                 450

 caa aat gta att tat gtt ctt gga tca gag gta gag att aca gat gct     1807
 Gln Asn Val Ile Tyr Val Leu Gly Ser Glu Val Glu Ile Thr Asp Ala
         455                 460                 465

 ttt aac cca tca ctt gat tgc ttt ttt aaa tac aat gct aca act gat     1855
 Phe Asn Pro Ser Leu Asp Cys Phe Phe Lys Tyr Asn Ala Thr Thr Asp
     470                 475                 480

 cag tgg tct gaa cta gta gca gag ttt ggg caa ttt ttt cat gca aca     1903
 Gln Trp Ser Glu Leu Val Ala Glu Phe Gly Gln Phe Phe His Ala Thr
 485                 490                 495                 500

 tta att aaa gct gta cca gta aac tgt aca ctg tat ata tgt gac ctt     1951
 Leu Ile Lys Ala Val Pro Val Asn Cys Thr Leu Tyr Ile Cys Asp Leu
                 505                 510                 515

 tcc acc tat aag gtt tat agt ttt tgt cca gac act tgt gtt tgg aaa     1999
 Ser Thr Tyr Lys Val Tyr Ser Phe Cys Pro Asp Thr Cys Val Trp Lys
             520                 525                 530

 ggc gaa gga tct ttt gag tgt gca ggc ttt aat gca ggt gca att gga     2047
 Gly Glu Gly Ser Phe Glu Cys Ala Gly Phe Asn Ala Gly Ala Ile Gly
         535                 540                 545

 att gaa gat aaa att tat ata tta ggt ggt gat tat gca cca gat gaa     2095
 Ile Glu Asp Lys Ile Tyr Ile Leu Gly Gly Asp Tyr Ala Pro Asp Glu
     550                 555                 560

 atc aca gat gaa gtg cag gtc tac cac agc aac agg tct gaa tgg gaa     2143
 Ile Thr Asp Glu Val Gln Val Tyr His Ser Asn Arg Ser Glu Trp Glu
 565                 570                 575                 580

 gaa gtt tca cca atg cct aga gcc tta aca gaa ttt tac tgc cag gtg     2191
 Glu Val Ser Pro Met Pro Arg Ala Leu Thr Glu Phe Tyr Cys Gln Val
                 585                 590                 595

 att cag ttt aat aaa tac aga gac cca tgg ttt tct aat cta tgt gct     2239
 Ile Gln Phe Asn Lys Tyr Arg Asp Pro Trp Phe Ser Asn Leu Cys Ala
             600                 605                 610

 tga acat tctaaaacga gtccagttct agtaacctaa agtaaatttg ttaaccaaaa     2296
 






      <210> 278
      <211> 2489
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (516)..(2279)

      <400> 278
 cttttgctat cattaaactc ctcctttaaa gacagtggag aggctgagag aggagcatgt     60

 atttttaaga gactgttatt tttagaacag tgtttttcca gggggaaaaa cgtgagtgat    120

 tctccctttt ttacaacaca caaggggtcc ctcagaccct gaggccacca ggaaccaaag    180

 tggtgagaga attcttggca aaaattttac atatttctaa gatttgggag ggcaaagtga    240

 ctgaggtggc taattctcac cttagcacta ggtgaagacc ccatgggtgg aggctgtctg    300

 ggttgtcttg ggtcctatca aagaggaatg actggacaaa cccacccacc agagtcggtg    360

 ggccactgaa tgcccagagg aagcactggg gcagcagctg gagaagaggc tatgcccatg    420

 agaagggaag tgtatctgga ggttccaagc agcaggttct cttggaagga gttggtgatg    480

 ttcagagatg tggctataga tgtctctcag gagga   atg gga atg cct gaa ccc     533
                                          Met Gly Met Pro Glu Pro
                                            1               5

 agc gca gag gaa ttt gta caa gga gaa gaa aac tgg aaa gct gaa gac      581
 Ser Ala Glu Glu Phe Val Gln Gly Glu Glu Asn Trp Lys Ala Glu Asp
              10                  15                  20

 ttt tta gtg aaa ttc aag gaa cac caa gag aag tat tct aga tca gtt      629
 Phe Leu Val Lys Phe Lys Glu His Gln Glu Lys Tyr Ser Arg Ser Val
          25                  30                  35

 gta agc atc aac cac aaa aaa ctg gtg aag gag aag agt aaa ata tat      677
 Val Ser Ile Asn His Lys Lys Leu Val Lys Glu Lys Ser Lys Ile Tyr
      40                  45                  50

 gaa aag aca ttt act cta ggc aaa aac cct gtg aat tca aaa aat cta      725
 Glu Lys Thr Phe Thr Leu Gly Lys Asn Pro Val Asn Ser Lys Asn Leu
  55                  60                  65                  70

 cct cct gaa tat gat act cat gga agg att ttg aaa aat gtt tca gaa      773
 Pro Pro Glu Tyr Asp Thr His Gly Arg Ile Leu Lys Asn Val Ser Glu
                  75                  80                  85

 tta atc atc agt aat cta aat cct gca aga aag aga ctt agt gag tat      821
 Leu Ile Ile Ser Asn Leu Asn Pro Ala Arg Lys Arg Leu Ser Glu Tyr
              90                  95                 100

 aat gga tat ggg aaa tca ctc ctg agt act aaa caa gag act act cat      869
 Asn Gly Tyr Gly Lys Ser Leu Leu Ser Thr Lys Gln Glu Thr Thr His
         105                 110                 115

 cct gaa gtc aaa tcc cat aat caa agt gcc aga gct ttc agt cat aat      917
 Pro Glu Val Lys Ser His Asn Gln Ser Ala Arg Ala Phe Ser His Asn
     120                 125                 130

 gaa gtt ctt atg cag tat cag aaa acg gaa act cca gca cag tca ttt      965
 Glu Val Leu Met Gln Tyr Gln Lys Thr Glu Thr Pro Ala Gln Ser Phe
 135                 140                 145                 150

 gga tat aat gac tgt gag aaa tca ttc ctt caa agg gga ggc ctg att     1013
 Gly Tyr Asn Asp Cys Glu Lys Ser Phe Leu Gln Arg Gly Gly Leu Ile
                 155                 160                 165

 aca cat agt aga cct tac aaa gga gaa aac cca tct gta tat aat aaa     1061
 Thr His Ser Arg Pro Tyr Lys Gly Glu Asn Pro Ser Val Tyr Asn Lys
             170                 175                 180

 aaa aga aga gca acc aat att gaa aaa aaa cat aca tgc aat gaa tgt     1109
 Lys Arg Arg Ala Thr Asn Ile Glu Lys Lys His Thr Cys Asn Glu Cys
         185                 190                 195

 ggg aaa tct ttc tgc agg aaa tca gta ttg att ctg cat cag gga att     1157
 Gly Lys Ser Phe Cys Arg Lys Ser Val Leu Ile Leu His Gln Gly Ile
     200                 205                 210

 cac tca gaa gaa aaa ccc tat caa tgt cat caa tgt gga aat gca ttt     1205
 His Ser Glu Glu Lys Pro Tyr Gln Cys His Gln Cys Gly Asn Ala Phe
 215                 220                 225                 230

 aga agg aaa tca tat ctc att gat cat cag agg act cac aca gga gag     1253
 Arg Arg Lys Ser Tyr Leu Ile Asp His Gln Arg Thr His Thr Gly Glu
                 235                 240                 245

 aaa ccc ttt gtt tgc aat gaa tgt ggt aag tcc ttc cgc ctc aag aca     1301
 Lys Pro Phe Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Leu Lys Thr
             250                 255                 260

 gcc ctc act gat cat cag aga aca cac aca ggg gag aaa tcg tat gaa     1349
 Ala Leu Thr Asp His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu
         265                 270                 275

 tgt ctg caa tgt agg aat gcc ttc aga ttg aag tca cac ctc att cgt     1397
 Cys Leu Gln Cys Arg Asn Ala Phe Arg Leu Lys Ser His Leu Ile Arg
     280                 285                 290

 cat cag aga act cac acg gga gag aaa cca tat gag tgt aat gac tgt     1445
 His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Asp Cys
 295                 300                 305                 310

 ggg aag tcc ttc cgc cag aag aca aca ctc tct cta cat cag aga atc     1493
 Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Ser Leu His Gln Arg Ile
                 315                 320                 325

 cat aca ggt gag aaa ccc tat att tgt aaa gaa tgt ggg aag tcc ttt     1541
 His Thr Gly Glu Lys Pro Tyr Ile Cys Lys Glu Cys Gly Lys Ser Phe
             330                 335                 340

 cac cag aag gca aat ctt act gta cat cag aga act cat aca ggg gaa     1589
 His Gln Lys Ala Asn Leu Thr Val His Gln Arg Thr His Thr Gly Glu
         345                 350                 355

 aag ccc tat att tgt aat gaa tgt ggg aaa tcc ttc tcc cag aag aca     1637
 Lys Pro Tyr Ile Cys Asn Glu Cys Gly Lys Ser Phe Ser Gln Lys Thr
     360                 365                 370

 acc ctt gct ctt cat gag aaa act cat aat gag gag aaa ccc tat att     1685
 Thr Leu Ala Leu His Glu Lys Thr His Asn Glu Glu Lys Pro Tyr Ile
 375                 380                 385                 390

 tgt agt gaa tgt gga aag tcc ttc cgc cag aag aca acc ctt gta gca     1733
 Cys Ser Glu Cys Gly Lys Ser Phe Arg Gln Lys Thr Thr Leu Val Ala
                 395                 400                 405

 cat cag aga aca cat aca ggg gag aaa tct tat gaa tgt cct cac tgt     1781
 His Gln Arg Thr His Thr Gly Glu Lys Ser Tyr Glu Cys Pro His Cys
             410                 415                 420

 ggg aag gcc ttt aga atg aag tca tac ctc att gat cat cac cga act     1829
 Gly Lys Ala Phe Arg Met Lys Ser Tyr Leu Ile Asp His His Arg Thr
         425                 430                 435

 cac aca gga gag aaa cca tat gaa tgt aat gaa tgt ggt aaa tca ttc     1877
 His Thr Gly Glu Lys Pro Tyr Glu Cys Asn Glu Cys Gly Lys Ser Phe
     440                 445                 450

 agt caa aag aca aat ctc aat cta cat cag aga att cat aca ggg gag     1925
 Ser Gln Lys Thr Asn Leu Asn Leu His Gln Arg Ile His Thr Gly Glu
 455                 460                 465                 470

 aaa ccc tat gtt tgt aat gaa tgt ggg aag tcc ttt cgc cag aaa gca     1973
 Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe Arg Gln Lys Ala
                 475                 480                 485

 acc ctc act gta cat cag aaa ata cat acc ggc cag aaa tcc tat gaa     2021
 Thr Leu Thr Val His Gln Lys Ile His Thr Gly Gln Lys Ser Tyr Glu
             490                 495                 500

 tgt cct cag tgt ggg aaa gcc ttt agc agg aag tca tat ctc att cat     2069
 Cys Pro Gln Cys Gly Lys Ala Phe Ser Arg Lys Ser Tyr Leu Ile His
         505                 510                 515

 cat caa aga act cat acg gga gag aaa cca tat aaa tgt agt gaa tgt     2117
 His Gln Arg Thr His Thr Gly Glu Lys Pro Tyr Lys Cys Ser Glu Cys
     520                 525                 530

 gga aag tgc ttc cgc cag aag aca aat ctt att gta cat cag aga act     2165
 Gly Lys Cys Phe Arg Gln Lys Thr Asn Leu Ile Val His Gln Arg Thr
 535                 540                 545                 550

 cac aca ggt gag aaa ccc tat gtt tgt aat gag tgt ggt aag tct ttc     2213
 His Thr Gly Glu Lys Pro Tyr Val Cys Asn Glu Cys Gly Lys Ser Phe
                 555                 560                 565

 agt tat aag aga aac ctc att gtc cat caa aga act cac aag gga gaa     2261
 Ser Tyr Lys Arg Asn Leu Ile Val His Gln Arg Thr His Lys Gly Glu
             570                 575                 580

 aac att gaa atg caa taa atgatg tggtttctta tatgaattct ttacaagctg     2315
 Asn Ile Glu Met Gln 
         585

 ttgtaaacat ttagttttaa aaagaaaagc atgctgaaac atgttaatgt aattttaaat   2375

 cacaagtcta ataattatta aagtaccata cggaataact gtctactgtt tactagcata   2435

 taaaataagt atgatcatta ttattgaact ctatcagcta tgaagctaaa tttt         2489




      <210> 279
      <211> 3956
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (311)..(1945)

      <400> 279
 tttcgtgcac tggcgaccct agcgggtgag aggcccttca gggccgcggc gggttgagcg     60

 caccatcaca tctaagccat cagcaagttt gttggtttta atctccaaaa tacgtcttga    120

 ttttgtctga ctctttgcca ccaccctgat ctaagccctt atcatctgct tgaatcacta    180

 acttgtctcc acttgcagtt tttaaaagag ttgcttccat ttgacttttt ctgtctgctg    240

 taccagcata tgagtttcag gaggggtcat tgatgcagtc attctcagtc tcctcggagg    300

 gagtctgaag   atg ctt aaa gag cat cca gag atg gcg gaa gct cct cag     349
              Met Leu Lys Glu His Pro Glu Met Ala Glu Ala Pro Gln
                1               5                  10

 cag cag ttg ggt att cct gtg gtg aaa ctg gag aaa gag ttg cca tgg      397
 Gln Gln Leu Gly Ile Pro Val Val Lys Leu Glu Lys Glu Leu Pro Trp
      15                  20                  25

 ggc aga gga agg gag gac cct agt cca gag act ttt cgg ctg agg ttt      445
 Gly Arg Gly Arg Glu Asp Pro Ser Pro Glu Thr Phe Arg Leu Arg Phe
  30                  35                  40                  45

 cgg cag ttc cgc tac cag gag gca gct gga ccc cag gaa gct ctt agg      493
 Arg Gln Phe Arg Tyr Gln Glu Ala Ala Gly Pro Gln Glu Ala Leu Arg
                  50                  55                  60

 gag ctc cag gag ctc tgt cgt cgg tgg ctg agg ccc gag ttg cac acc      541
 Glu Leu Gln Glu Leu Cys Arg Arg Trp Leu Arg Pro Glu Leu His Thr
              65                  70                  75

 aag gag cag atc ctg gag ctg ctg gtg ctg gag cag ttc ctc act atc      589
 Lys Glu Gln Ile Leu Glu Leu Leu Val Leu Glu Gln Phe Leu Thr Ile
          80                  85                  90

 ctg ccc cgc gag ttc tac gcc tgg atc cgg gag cat ggc cca gag agt      637
 Leu Pro Arg Glu Phe Tyr Ala Trp Ile Arg Glu His Gly Pro Glu Ser
      95                 100                 105

 ggc aag gcc ctg gcc gcc atg gtg gag gac ctg aca gaa aga gca ctg      685
 Gly Lys Ala Leu Ala Ala Met Val Glu Asp Leu Thr Glu Arg Ala Leu
 110                 115                 120                 125

 gag gcc aag gcg gtt cca tgc cac agg cag gga gag cag gag gaa aca      733
 Glu Ala Lys Ala Val Pro Cys His Arg Gln Gly Glu Gln Glu Glu Thr
                 130                 135                 140

 gca ctt tgc aga ggc gct tgg gag cca ggc atc cag ctg ggg cca gtg      781
 Ala Leu Cys Arg Gly Ala Trp Glu Pro Gly Ile Gln Leu Gly Pro Val
             145                 150                 155

 gag gtc aag cct gaa tgg ggg atg ccc cct ggg gaa gga gtt caa ggt      829
 Glu Val Lys Pro Glu Trp Gly Met Pro Pro Gly Glu Gly Val Gln Gly
         160                 165                 170

 cca gac cca ggt acc gag gag cag ctc agt cag gac cct gga gat gag      877
 Pro Asp Pro Gly Thr Glu Glu Gln Leu Ser Gln Asp Pro Gly Asp Glu
     175                 180                 185

 aca cgg gcc ttc cag gag caa gca cta cct gtt ctg cag gcg ggt cct      925
 Thr Arg Ala Phe Gln Glu Gln Ala Leu Pro Val Leu Gln Ala Gly Pro
 190                 195                 200                 205

 ggc ctc ccc gca gtg aat ccc aga gac caa gag atg gca gct ggg ttc      973
 Gly Leu Pro Ala Val Asn Pro Arg Asp Gln Glu Met Ala Ala Gly Phe
                 210                 215                 220

 ttt act gct gga tcg cag ggg ttg ggg cca ttt aaa gat atg gcc ctg     1021
 Phe Thr Ala Gly Ser Gln Gly Leu Gly Pro Phe Lys Asp Met Ala Leu
             225                 230                 235

 gcc ttc cct gag gag gag tgg agg cat gtg acc cca gcc cag ata gac     1069
 Ala Phe Pro Glu Glu Glu Trp Arg His Val Thr Pro Ala Gln Ile Asp
         240                 245                 250

 tgc ttt ggg gag tat gtg gaa ccg cag gac tgc agg gtc tct cca ggc     1117
 Cys Phe Gly Glu Tyr Val Glu Pro Gln Asp Cys Arg Val Ser Pro Gly
     255                 260                 265

 ggt ggg agc aag gaa aag gag gca aaa ccc cca cag gaa gac ctg aaa     1165
 Gly Gly Ser Lys Glu Lys Glu Ala Lys Pro Pro Gln Glu Asp Leu Lys
 270                 275                 280                 285

 ggg gcg ctg gtg gca ctg aca tca gag agg ttt ggg gaa gcc tct ctc     1213
 Gly Ala Leu Val Ala Leu Thr Ser Glu Arg Phe Gly Glu Ala Ser Leu
                 290                 295                 300

 cag ggc cct ggg ctc gga agg gtc tgt gag cag gag cct ggt ggc cct     1261
 Gln Gly Pro Gly Leu Gly Arg Val Cys Glu Gln Glu Pro Gly Gly Pro
             305                 310                 315

 gca ggc agt gcg cct ggg ctt cct cct ccc cag cac ggt gcc atc ccc     1309
 Ala Gly Ser Ala Pro Gly Leu Pro Pro Pro Gln His Gly Ala Ile Pro
         320                 325                 330

 ctg cct gac gaa gtc aaa acc cac agc tcc ttc tgg aag cct ttc cag     1357
 Leu Pro Asp Glu Val Lys Thr His Ser Ser Phe Trp Lys Pro Phe Gln
     335                 340                 345

 tgc cct gag tgt ggg aaa gga ttc agt cgg agc tcc aat ctc gtc agg     1405
 Cys Pro Glu Cys Gly Lys Gly Phe Ser Arg Ser Ser Asn Leu Val Arg
 350                 355                 360                 365

 cac cag cga acc cac gaa gag aag tct tat ggc tgt gtg gag tgt ggg     1453
 His Gln Arg Thr His Glu Glu Lys Ser Tyr Gly Cys Val Glu Cys Gly
                 370                 375                 380

 aag ggc ttt acc ctg aga gaa tac ctg atg aag cac cag aga acc cac     1501
 Lys Gly Phe Thr Leu Arg Glu Tyr Leu Met Lys His Gln Arg Thr His
             385                 390                 395

 ctg gga aag agg ccc tac gtg tgc agc gag tgc tgg aaa acc ttc agc     1549
 Leu Gly Lys Arg Pro Tyr Val Cys Ser Glu Cys Trp Lys Thr Phe Ser
         400                 405                 410

 cag aga cac cac ctg gag gtg cac cag cgc agc cac act ggg gag aag     1597
 Gln Arg His His Leu Glu Val His Gln Arg Ser His Thr Gly Glu Lys
     415                 420                 425

 ccc tac aag tgc ggg gac tgc tgg aag agc ttc agc cgc agg cag cac     1645
 Pro Tyr Lys Cys Gly Asp Cys Trp Lys Ser Phe Ser Arg Arg Gln His
 430                 435                 440                 445

 ctg cag gtg cac cgg agg acg cac acc ggg gag aag ccc tac acc tgc     1693
 Leu Gln Val His Arg Arg Thr His Thr Gly Glu Lys Pro Tyr Thr Cys
                 450                 455                 460

 gag tgt ggc aag agc ttc agc agg aat gcc aat ctg gcg gtg cac cgg     1741
 Glu Cys Gly Lys Ser Phe Ser Arg Asn Ala Asn Leu Ala Val His Arg
             465                 470                 475

 cgt gcc cac act ggc gag aag cca tat ggg tgc cag gtg tgc ggg aag     1789
 Arg Ala His Thr Gly Glu Lys Pro Tyr Gly Cys Gln Val Cys Gly Lys
         480                 485                 490

 cgg ttc agc aaa ggg gag cgg ctg gtc cga cac cag aga atc cat aca     1837
 Arg Phe Ser Lys Gly Glu Arg Leu Val Arg His Gln Arg Ile His Thr
     495                 500                 505

 ggg gag aag ccc tac cac tgt cct gcc tgc ggg cga agc ttc aac cag     1885
 Gly Glu Lys Pro Tyr His Cys Pro Ala Cys Gly Arg Ser Phe Asn Gln
 510                 515                 520                 525

 agg tcc atc ctc aac cgg cac cag aag acc cag cac cgc cag gag ccg     1933
 Arg Ser Ile Leu Asn Arg His Gln Lys Thr Gln His Arg Gln Glu Pro
                 530                 535                 540

 ctg gtg cag tga gca tagcaggtgg caggcagcac catcattcat ctttctcact     1988
 Leu Val Gln 


 gcagggcctt gcggggtgca aggtgatggc tgcaggaaag cactggtccc atcgccttcc   2048

 cacccattcg ccaacgcggg aaaggcaagg cctggcttac ttagagcttc cagagagcat   2108

 agctgcttcc atctcttacc caagtggtgc taaacaattt ttcttccaat gtttgaggga   2168

 agcagtctcc tgcggttcag ttcaggctga gattttctcc ttcagtggac tgtctgtgtc   2228

 cccctgccga acaaagctgg gagtaaaggc aaaaccttga cacgtgttgg tagctgggac   2288

 ctcatcttcc tgagggctct gtcttgcctg cagggtcata gctcagactc ttcccccacc   2348

 ccctctcttt tccattgaac aaacatttat tgaacatcct ctgagcacct ggccgtggga   2408

 atgccgtggt gaatgagaga ctagacgtga tgcctctggg ggttgtgcgt tggggatgca   2468

 tgcgacagcc catgacccga ggcattctca gggtatctgt gctgtgtgcc cgtgagaaca   2528

 tcttcccatg accactcctg ccctcctgcc ccgtgctgga tcttccctcc ccagctggga   2588

 tctgctccca ggcaactgtg tgaattttac attatttgga gcctcatctg tgtcaggcta   2648

 taacattcta tcctcatctg taaaacttcc ccgtccatta ttccttgcac tataacaact   2708

 gtcaacacac caactattag gaagttagta ttttgctatt gatcactgaa taaacatcag   2768

 agtattttaa aaaacagttc tctagaaaga actgttataa ttaaaatgag tctgaaagat   2828

 gaactctagt attaatgccc tatatttgat ggcactttat agttcataaa attaatttca   2888

 ccccattctc attggaccca tttcccaagt atttattgag gccctgtaac aaacatgtca   2948

 ggaactcttc tgggtgcttg agacacatcc atgaataaaa tagggggaga agctgttgac   3008

 ctcgtagagc ttatgtctcg tggatgtacc tgatcttcag aacccgtgga tattcctgca   3068

 aatcctctgg gcctgtattc attgctttgt cagcatcttg ccctgaaatg catttgtcac   3128

 ctacctcttg ttactaaatg gtctctgccc tccagaccct tgtcatccaa ggcactaggg   3188

 gtcctggaca cccactgggg atgatgagct ggtagcgacc tgttttgcat gagtgccaag   3248

 tcaggaaaaa taaagatatt tgtaggcatt aaaaaaaaat acatttcttt aaaaatgaga   3308

 agatgcaata tttgtaaact gttgaagctt ccttattgtg ccatcactta agggtttcat   3368

 ttctgtttaa cagttctgga agctgcataa ctagcgtgga ctgactgctg tgtcattgtg   3428

 ctgtgccttt gaaccctggc tgagtgagtg agtttgtcct ttgttgatag tgtcctatac   3488

 attgcaaaat gtggttagtc ttctgagtgc ctcttaatac cagattcttt tactgagcat   3548

 tttctttact tcgcattatc tccattgtac cactaacggt aacactggct acctgactaa   3608

 ccacccacag ctgtaattac tcaggcccac tttgaaacgt ggcttaaatt caccgtgccc   3668

 tatagttacg ggcagcatgg ctgtctactc ttgggcttca gcacaatgcc cgcttccggt   3728

 gagtctttcc gtggcgtcac ttaagcttgt gcccagcgga ggcctgccct gactggggtc   3788

 gctaattcgt gtctggagat gttccccacg ggggctgcgg ttgtcccttt gcaagccctg   3848

 gcgtccacat tgcaacatcc agccttttac ccccccgtag tatcaacccc gcttatccgc   3908

 ggctacccac agtcgcccag ggcgcctcct gcctccagtc cttcccgg                3956




      <210> 280
      <211> 1972
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1458)

      <400> 280
  atg cgg gag aga ata ttt gac ctt aga ttt gtc cgc ctg cat ctt tct      48
  Met Arg Glu Arg Ile Phe Asp Leu Arg Phe Val Arg Leu His Leu Ser
    1               5                  10                  15

 cct gac gcc aac ctc agt tcc tcc tct gac tgc ctc tct cca tct gta       96
 Pro Asp Ala Asn Leu Ser Ser Ser Ser Asp Cys Leu Ser Pro Ser Val
              20                  25                  30

 ttg caa aac acc aaa ctc tct gcc aaa gaa cac atc cta aag gtc ccg      144
 Leu Gln Asn Thr Lys Leu Ser Ala Lys Glu His Ile Leu Lys Val Pro
          35                  40                  45

 ctt cta atc cca tca tct ctc cat acc gcc ctc tgc cgg cct ttc ctc      192
 Leu Leu Ile Pro Ser Ser Leu His Thr Ala Leu Cys Arg Pro Phe Leu
      50                  55                  60

 tgg tcg ccc gga ttg cga gcc gct tcc gga cgc tcc gga agc gaa cct      240
 Trp Ser Pro Gly Leu Arg Ala Ala Ser Gly Arg Ser Gly Ser Glu Pro
  65                  70                  75                  80

 ttc ttt tcc gga ttg ggc atc ccg gca tct gca cgt ggt tat gct gcc      288
 Phe Phe Ser Gly Leu Gly Ile Pro Ala Ser Ala Arg Gly Tyr Ala Ala
                  85                  90                  95

 gga gtt tgg gcc gcc act gta gga aaa gta act tca gct gca gcc cca      336
 Gly Val Trp Ala Ala Thr Val Gly Lys Val Thr Ser Ala Ala Ala Pro
             100                 105                 110

 aag cga gtg agc cga gcc gga gcc atg gag ggc cag agc gtg gag gag      384
 Lys Arg Val Ser Arg Ala Gly Ala Met Glu Gly Gln Ser Val Glu Glu
         115                 120                 125

 ctg ctc gca aag gca gag cag gac gag gca gag aag ttg caa cgc atc      432
 Leu Leu Ala Lys Ala Glu Gln Asp Glu Ala Glu Lys Leu Gln Arg Ile
     130                 135                 140

 acg gtg cac aag gag ctg gag ctg cag ttt gac ctg ggc aac ctg ctg      480
 Thr Val His Lys Glu Leu Glu Leu Gln Phe Asp Leu Gly Asn Leu Leu
 145                 150                 155                 160

 gcg tcg gac cgg aac ccc ccg acc ggg ctg cgg tgc gcc gga ccc acg      528
 Ala Ser Asp Arg Asn Pro Pro Thr Gly Leu Arg Cys Ala Gly Pro Thr
                 165                 170                 175

 ccg gag gcc gag cta cag gcc ctg gcg cgg gac aac acg caa ctg ctc      576
 Pro Glu Ala Glu Leu Gln Ala Leu Ala Arg Asp Asn Thr Gln Leu Leu
             180                 185                 190

 atc aac cag ctg tgg cag ctg ccc acg gag cgc gtg gaa gag gcg ata      624
 Ile Asn Gln Leu Trp Gln Leu Pro Thr Glu Arg Val Glu Glu Ala Ile
         195                 200                 205

 gtg gcg cgg ctg ccg gag ccc acc aca cgc ctg ccg cga gag aag cct      672
 Val Ala Arg Leu Pro Glu Pro Thr Thr Arg Leu Pro Arg Glu Lys Pro
     210                 215                 220

 ctg ccc cga ccg cgg cca ctt aca cgc tgg cag cag ttc gcg cgc ctc      720
 Leu Pro Arg Pro Arg Pro Leu Thr Arg Trp Gln Gln Phe Ala Arg Leu
 225                 230                 235                 240

 aag ggc atc cgt ccc aag aag aag acc aac ctg gtg tgg gac gag gtg      768
 Lys Gly Ile Arg Pro Lys Lys Lys Thr Asn Leu Val Trp Asp Glu Val
                 245                 250                 255

 agt ggc cag tgg cgg cgg cgc tgg ggc tac cag cgc gcc cgg gac gac      816
 Ser Gly Gln Trp Arg Arg Arg Trp Gly Tyr Gln Arg Ala Arg Asp Asp
             260                 265                 270

 acc aaa gaa tgg ctg att gag gtg ccc ggc aat gcc gac ccc ttg gag      864
 Thr Lys Glu Trp Leu Ile Glu Val Pro Gly Asn Ala Asp Pro Leu Glu
         275                 280                 285

 gac cag ttc gcc aag cgg att cag gcc aag aag gaa agg gtg gcc aag      912
 Asp Gln Phe Ala Lys Arg Ile Gln Ala Lys Lys Glu Arg Val Ala Lys
     290                 295                 300

 aac gag ctg aac cgg ctg cgt aac ctg gcc cgc gcg cac aag atg cag      960
 Asn Glu Leu Asn Arg Leu Arg Asn Leu Ala Arg Ala His Lys Met Gln
 305                 310                 315                 320

 ctg ccc agc gcg gcc ggc ttg cac cct acc gga cac cag agt aag gag     1008
 Leu Pro Ser Ala Ala Gly Leu His Pro Thr Gly His Gln Ser Lys Glu
                 325                 330                 335

 gag ctg ggc cgc gcc atg caa gtg gcc aag gtc tcc acc gcc tct gtg     1056
 Glu Leu Gly Arg Ala Met Gln Val Ala Lys Val Ser Thr Ala Ser Val
             340                 345                 350

 ggg cgc ttt cag gag cgc ctc ccc aag gag aag gtg ccc cgg ggc tcc     1104
 Gly Arg Phe Gln Glu Arg Leu Pro Lys Glu Lys Val Pro Arg Gly Ser
         355                 360                 365

 ggc aag aaa agg aag ttt caa ccc ctt ttc ggg gac ttt gca gcc gag     1152
 Gly Lys Lys Arg Lys Phe Gln Pro Leu Phe Gly Asp Phe Ala Ala Glu
     370                 375                 380

 aaa aag aac cag ttg gag ctg ctt cgt gtc atg aac agc aag aag cct     1200
 Lys Lys Asn Gln Leu Glu Leu Leu Arg Val Met Asn Ser Lys Lys Pro
 385                 390                 395                 400

 cag ctg gat gtg act agg gcc acc aat aag cag atg agg gag gag gac     1248
 Gln Leu Asp Val Thr Arg Ala Thr Asn Lys Gln Met Arg Glu Glu Asp
                 405                 410                 415

 cag gag gag gcc gcc aag agg agg aaa atg agc cag aag ggc aag aga     1296
 Gln Glu Glu Ala Ala Lys Arg Arg Lys Met Ser Gln Lys Gly Lys Arg
             420                 425                 430

 aag gga ggc cgg cag ggg cct ggg ggc aag agg aaa ggg ggc ccg ccc     1344
 Lys Gly Gly Arg Gln Gly Pro Gly Gly Lys Arg Lys Gly Gly Pro Pro
         435                 440                 445

 agc cag gga ggg aag agg aaa ggg ggc ttg gga ggc aag atg aat tct     1392
 Ser Gln Gly Gly Lys Arg Lys Gly Gly Leu Gly Gly Lys Met Asn Ser
     450                 455                 460

 ggg ccg cct ggc ttg ggt ggc aag aga aaa gga gga cag cgc cca gga     1440
 Gly Pro Pro Gly Leu Gly Gly Lys Arg Lys Gly Gly Gln Arg Pro Gly
 465                 470                 475                 480

 gga aag agg agg aag taa tagttt ctaactgtcg gacccgtctg taaaccaagg     1494
 Gly Lys Arg Arg Lys 
                 485

 actatgaata ctaaatgtta agttctaggc aattatacgg ggactcagaa ggacctggcc   1554

 gctgccttca ttgagtttaa agggacagga ttgcccttcc gtcaagaaag tatgtaagtg   1614

 ttggactgca caaattaatg tttttcccac aaccgagact ttggagatta agaacttatt   1674

 tgaggattta agaattaggg aaataatttg gtggaaaccg ggaatgagtt ctattcttaa   1734

 acagcctttt tttttctttt taatgttgga tatacggcga ggtagagttg gccatatttc   1794

 agagacttag attgacgtat atgtttctgc attattttta caacaagttt gtgtatcaga   1854

 gcgggagtgc gggggaggga aagaaaacaa acagtttcag aattgaatag gcaagtgact   1914

 gttttaaaga ttaagtaata aagatgtctt atctagtgtg acttttaaaa aaaaaaaa     1972




      <210> 281
      <211> 2229
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (374)..(841)

      <400> 281
 ctacatttta gaaaggcagt aggaagaagt ttatacaagt caaaagaatt gttttaaagg     60

 gaaagtaaag gaaaatatct gttagtggct tattcgaggt gtgtcagttg attaatttcc    120

 tttctctcaa ccataagttt tctttgctct gttatatatt attagggttt cctagttact    180

 ctaaaagacc ttctgttgga acaatttgtt tttctcaagc acaacccatc tccaacttgt    240

 ctgtatttct gagactttca agaaatgttg gttatcattt taattgattt tctgctagga    300

 tggaaaaaaa gagccaagtt catgtacctg tttgaagggg cccaaactgt cagaaatagg    360

 gacgattgcc tgg   atg ata acg ctc tgc gat gcc ctc cac aat ttc atc     409
                  Met Ile Thr Leu Cys Asp Ala Leu His Asn Phe Ile
                    1               5                  10

 gat ggc ctg gcg att ggg gct tcc tgc acc ttg tct ctc ctt cag gga      457
 Asp Gly Leu Ala Ile Gly Ala Ser Cys Thr Leu Ser Leu Leu Gln Gly
          15                  20                  25

 ctc agt act tcc ata gca atc cta tgt gag gag ttt ccc cac gag tta      505
 Leu Ser Thr Ser Ile Ala Ile Leu Cys Glu Glu Phe Pro His Glu Leu
      30                  35                  40

 gga gac ttt gtg atc cta ctc aat gca ggg atg agc act cga caa gcc      553
 Gly Asp Phe Val Ile Leu Leu Asn Ala Gly Met Ser Thr Arg Gln Ala
  45                  50                  55                  60

 ttg cta ttc aac ttc ctt tct gca tgt tcc tgc tat gtt ggg cta gct      601
 Leu Leu Phe Asn Phe Leu Ser Ala Cys Ser Cys Tyr Val Gly Leu Ala
                  65                  70                  75

 ttt ggc att ttg gtg ggc aac aat ttc gct cca aat att ata ttt gca      649
 Phe Gly Ile Leu Val Gly Asn Asn Phe Ala Pro Asn Ile Ile Phe Ala
              80                  85                  90

 ctt gct gga ggc atg ttc ctc tat att tct ctg gca gat atg ttt cca      697
 Leu Ala Gly Gly Met Phe Leu Tyr Ile Ser Leu Ala Asp Met Phe Pro
          95                 100                 105

 gag atg aat gat atg ctg aga gaa aag gta act gga aga aaa acc gat      745
 Glu Met Asn Asp Met Leu Arg Glu Lys Val Thr Gly Arg Lys Thr Asp
     110                 115                 120

 ttc acc ttc ttc atg att cag aat gct gga atg tta act gga ttc aca      793
 Phe Thr Phe Phe Met Ile Gln Asn Ala Gly Met Leu Thr Gly Phe Thr
 125                 130                 135                 140

 gcc att cta ctc att acc ttg tat gca gga gaa atc gaa ttg gag taa      841
 Ala Ile Leu Leu Ile Thr Leu Tyr Ala Gly Glu Ile Glu Leu Glu 
                 145                 150                 155

 tagaaaatgg aagatggtgt tgttaataaa ggcatttaat agataaaaac atctccaaaa    901

 aggattttga agctgatcct atttagttaa aaagataatt ttgctttcaa ctgtaggtcc    961

 agaaaactaa ttattggcat cagtctgtga aatagtccat tatttgttgt taaaaatgct   1021

 tcaaaaggtt ttcagtgtca gtctgagatg cctggtatat aggagccttt gggaaatacc   1081

 tatttttcag tattccatgc atattggata tcaccatgaa gcaagagaca tgcattctat   1141

 aatcatgtag acactcagac tcaggggaaa atacaagtta tatcctgaaa gcctttaaaa   1201

 ctctatggta ggatcaaaga ttcaaatggt ttcagagagg ttttatttca attaatttgt   1261

 tctagtgctt tcaagagcaa gtacatcaaa atgtagaagg taaaatgtat gcaacactaa   1321

 tataaattat tccaagtctt taaggagcca aagaaaaaaa agatttctca cagctttttg   1381

 ttctgttttg tatttcaatt aggaacttgc agtattattt tgaaaaccat tctaaaataa   1441

 taggagttag gaaataaata aagttttgct agccctgcta agttcaggct tagaggctta   1501

 tcgctaagtg taaacttcac cagattccac gaaaagctgg atagcttttt ttctgactta   1561

 tgttgtggtt gcacccctca caaatggcag aacagtatgt aaagctggta acacctcggt   1621

 ttcagtgcac catgtgtttg ctttgtgaag gtgaagaata tgttggttta gagaaagaaa   1681

 ttggatgtaa ttttatgcaa tttactttta aagacaaaca taactattta gcagagaata   1741

 ttttaataaa tgcaaaacaa cagctggact gctgtacatc aaggacagat taactggaaa   1801

 acatatgttc cttatgtgtg attgagagcc attcagaaaa gacttccttt gtgttcagcc   1861

 tatacttttc catatggtat accttgaaaa aaattagcac accatggtta tttttctacc   1921

 ttttataaaa gacagagcct gtttactcat ttagaagata gagaaaattg gtctaaaatt   1981

 gaacatccta gattcacact cccaagtcac ttaaggtgat ttgatggtga ggaaaatgat   2041

 tgacaaagcc caacaatgat ctcaggaatt acattttcca acagaccaaa aaatgttttc   2101

 atgtagcagc aatgcagatt tggtgaatat ttaatatata ttttagtatg tatttcactt   2161

 tatgactgac aattaaaaaa tattgtttgg ccaaatagta aacacccttt tgaaaccaaa   2221

 aaaaaaaa                                                            2229




      <210> 282
      <211> 2654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (167)..(2377)

      <400> 282
 tggtgttttc aggactcggt tggatgcctc agccatagta agtgggaaag tgagcgagca     60

 agcgagctac tagcgaccgg aggaaagtga acagggggag aagggaacag caagaacagg    120

 actccagagc gataaacact cgctggagag ggagacgcag gaagcg   atg aaa gag     175
                                                      Met Lys Glu
                                                        1

 atg tct gca aac acc gtg ctg gac agc cag cgt caa caa aag cat tat      223
 Met Ser Ala Asn Thr Val Leu Asp Ser Gln Arg Gln Gln Lys His Tyr
       5                  10                  15

 gga att acc tcc cca att agt ttg gca tct cct aaa gaa att gat cat      271
 Gly Ile Thr Ser Pro Ile Ser Leu Ala Ser Pro Lys Glu Ile Asp His
  20                  25                  30                  35

 att tac aca cag aaa tta att gac gcc atg aaa cca ttt gga gtg ttt      319
 Ile Tyr Thr Gln Lys Leu Ile Asp Ala Met Lys Pro Phe Gly Val Phe
                  40                  45                  50

 gaa gat gag gaa gaa ttg aac cac agg ctg gtg gtt ctt ggt aaa ttg      367
 Glu Asp Glu Glu Glu Leu Asn His Arg Leu Val Val Leu Gly Lys Leu
              55                  60                  65

 aac aat tta gta aaa gaa tgg att tct gat gtc agc gag agt aag aac      415
 Asn Asn Leu Val Lys Glu Trp Ile Ser Asp Val Ser Glu Ser Lys Asn
          70                  75                  80

 ctc cca cct tct gtt gtg gct act gtt ggt ggt aaa att ttc aca ttt      463
 Leu Pro Pro Ser Val Val Ala Thr Val Gly Gly Lys Ile Phe Thr Phe
      85                  90                  95

 gga tcc tat agg ctt gga gta cac acc aaa gga gct gac att gat gca      511
 Gly Ser Tyr Arg Leu Gly Val His Thr Lys Gly Ala Asp Ile Asp Ala
 100                 105                 110                 115

 ctt tgt gta gct cca aga cat gtg gaa aga tct gat ttt ttt cag tct      559
 Leu Cys Val Ala Pro Arg His Val Glu Arg Ser Asp Phe Phe Gln Ser
                 120                 125                 130

 ttt ttt gaa aaa ttg aaa cat caa gat ggc att aga aac tta aga gct      607
 Phe Phe Glu Lys Leu Lys His Gln Asp Gly Ile Arg Asn Leu Arg Ala
             135                 140                 145

 gta gaa gat gcc ttt gta cct gtt ata aaa ttt gaa ttt gat ggt att      655
 Val Glu Asp Ala Phe Val Pro Val Ile Lys Phe Glu Phe Asp Gly Ile
         150                 155                 160

 gaa att gat cta gtc ttt gca aga ctg gca ata caa acc ata tca gat      703
 Glu Ile Asp Leu Val Phe Ala Arg Leu Ala Ile Gln Thr Ile Ser Asp
     165                 170                 175

 aat tta gat cta aga gac gac tct cgc ctg aga agc ctt gat ata agg      751
 Asn Leu Asp Leu Arg Asp Asp Ser Arg Leu Arg Ser Leu Asp Ile Arg
 180                 185                 190                 195

 tgt att cgc agc tta aat ggt tgt aga gtt act gat gaa att ttg cat      799
 Cys Ile Arg Ser Leu Asn Gly Cys Arg Val Thr Asp Glu Ile Leu His
                 200                 205                 210

 tta gtg cca aat aaa gaa act ttt aga ctc acc cta aga gct gtc aaa      847
 Leu Val Pro Asn Lys Glu Thr Phe Arg Leu Thr Leu Arg Ala Val Lys
             215                 220                 225

 tta tgg gca aaa cga cgt ggt att tat tcc aac atg cta gga ttc ctt      895
 Leu Trp Ala Lys Arg Arg Gly Ile Tyr Ser Asn Met Leu Gly Phe Leu
         230                 235                 240

 ggt ggt gtc tcc tgg gca atg cta gtt gca aga act tgc caa ttg tat      943
 Gly Gly Val Ser Trp Ala Met Leu Val Ala Arg Thr Cys Gln Leu Tyr
     245                 250                 255

 cca aat gca gca gca tct act tta gtt cat aag ttc ttt tta gtt ttt      991
 Pro Asn Ala Ala Ala Ser Thr Leu Val His Lys Phe Phe Leu Val Phe
 260                 265                 270                 275

 tcc aag tgg gaa tgg cca aat cct gtg ctg ctg aag caa cca gaa gaa     1039
 Ser Lys Trp Glu Trp Pro Asn Pro Val Leu Leu Lys Gln Pro Glu Glu
                 280                 285                 290

 agc aat ttg aat ttg cct gtc tgg gat cct cgg gta aat cca tca gat     1087
 Ser Asn Leu Asn Leu Pro Val Trp Asp Pro Arg Val Asn Pro Ser Asp
             295                 300                 305

 agg tat cat ctc atg ccc ata atc acc cct gcc tac cca caa cag aat     1135
 Arg Tyr His Leu Met Pro Ile Ile Thr Pro Ala Tyr Pro Gln Gln Asn
         310                 315                 320

 tct acg tat aat gtg tcc aca tca act cga aca gta atg gta gaa gaa     1183
 Ser Thr Tyr Asn Val Ser Thr Ser Thr Arg Thr Val Met Val Glu Glu
     325                 330                 335

 ttt aaa caa ggt ctt gca gtc aca gat gaa att ctt caa gga aag tca     1231
 Phe Lys Gln Gly Leu Ala Val Thr Asp Glu Ile Leu Gln Gly Lys Ser
 340                 345                 350                 355

 gat tgg tcc aaa cta ctt gag cca ccg aat ttc ttt caa aag tat aga     1279
 Asp Trp Ser Lys Leu Leu Glu Pro Pro Asn Phe Phe Gln Lys Tyr Arg
                 360                 365                 370

 cat tat ata gta ttg act gcc agc gca tca aca gaa gaa aac cat cta     1327
 His Tyr Ile Val Leu Thr Ala Ser Ala Ser Thr Glu Glu Asn His Leu
             375                 380                 385

 gag tgg gtt gga tta gta gaa tct aaa atc cgt gta ctt gtt gga aac     1375
 Glu Trp Val Gly Leu Val Glu Ser Lys Ile Arg Val Leu Val Gly Asn
         390                 395                 400

 ttg gaa cgg aat gaa ttt att act ctt gcc cat gtg aat ccc cag tca     1423
 Leu Glu Arg Asn Glu Phe Ile Thr Leu Ala His Val Asn Pro Gln Ser
     405                 410                 415

 ttc cca ggg aat aag gaa cat cat aaa gac aac aat tac gta tca atg     1471
 Phe Pro Gly Asn Lys Glu His His Lys Asp Asn Asn Tyr Val Ser Met
 420                 425                 430                 435

 tgg ttc ctt ggg ata att ttt cgg aga gta gaa aat gca gaa agt gtc     1519
 Trp Phe Leu Gly Ile Ile Phe Arg Arg Val Glu Asn Ala Glu Ser Val
                 440                 445                 450

 aac ata gac ttg aca tat gat ata cag tca ttt act gat aca gtg tac     1567
 Asn Ile Asp Leu Thr Tyr Asp Ile Gln Ser Phe Thr Asp Thr Val Tyr
             455                 460                 465

 aga cag gca aac aat ata aat atg cta aag gag gga atg aaa att gaa     1615
 Arg Gln Ala Asn Asn Ile Asn Met Leu Lys Glu Gly Met Lys Ile Glu
         470                 475                 480

 gca act cat gta aag aaa aaa caa ctt cac cac tac ctt cct gca gaa     1663
 Ala Thr His Val Lys Lys Lys Gln Leu His His Tyr Leu Pro Ala Glu
     485                 490                 495

 att ctt caa aag aag aaa aag caa agt ctc tct gat gtc aat cga agc     1711
 Ile Leu Gln Lys Lys Lys Lys Gln Ser Leu Ser Asp Val Asn Arg Ser
 500                 505                 510                 515

 tcg ggc gga ctt caa tcc aaa aga ttg tct ctg gat agc agt tgt ctg     1759
 Ser Gly Gly Leu Gln Ser Lys Arg Leu Ser Leu Asp Ser Ser Cys Leu
                 520                 525                 530

 gat agc tcc aga gac act gat aat gga aca cct ttt aat tct cca gcg     1807
 Asp Ser Ser Arg Asp Thr Asp Asn Gly Thr Pro Phe Asn Ser Pro Ala
             535                 540                 545

 tcc aag tct gat agc cct tct gta gga gaa aca gaa agg aat agt gct     1855
 Ser Lys Ser Asp Ser Pro Ser Val Gly Glu Thr Glu Arg Asn Ser Ala
         550                 555                 560

 gag cct gct gct gta att gtg gag aag cca ctg agt gta cca cca gcc     1903
 Glu Pro Ala Ala Val Ile Val Glu Lys Pro Leu Ser Val Pro Pro Ala
     565                 570                 575

 caa gga ctt tcc att cca gtg att ggc gca aaa gtt gac tct aca gta     1951
 Gln Gly Leu Ser Ile Pro Val Ile Gly Ala Lys Val Asp Ser Thr Val
 580                 585                 590                 595

 aaa act gta tca ccc ccc act gtg tgt acc att cct acc gta gta gga     1999
 Lys Thr Val Ser Pro Pro Thr Val Cys Thr Ile Pro Thr Val Val Gly
                 600                 605                 610

 cga aat gtc att cct aga atc aca aca cct cac aac cct gcc cag gga     2047
 Arg Asn Val Ile Pro Arg Ile Thr Thr Pro His Asn Pro Ala Gln Gly
             615                 620                 625

 caa ccg cat ctg aat gga atg tca aat ata act aag act gtt aca cct     2095
 Gln Pro His Leu Asn Gly Met Ser Asn Ile Thr Lys Thr Val Thr Pro
         630                 635                 640

 aag aga tcc cat tcc cca tcc ata gat ggg act cct aag agg ttg aaa     2143
 Lys Arg Ser His Ser Pro Ser Ile Asp Gly Thr Pro Lys Arg Leu Lys
     645                 650                 655

 gac gta gaa aag ttt att cga ctt gaa tca aca ttt aag gac ccc cgc     2191
 Asp Val Glu Lys Phe Ile Arg Leu Glu Ser Thr Phe Lys Asp Pro Arg
 660                 665                 670                 675

 act gct gaa gaa aaa aaa aga gaa tca cag gat gcc att gga gga gaa     2239
 Thr Ala Glu Glu Lys Lys Arg Glu Ser Gln Asp Ala Ile Gly Gly Glu
                 680                 685                 690

 tct atg cct att cca act att gat aca tca cgc aaa aag aga cta ccc     2287
 Ser Met Pro Ile Pro Thr Ile Asp Thr Ser Arg Lys Lys Arg Leu Pro
             695                 700                 705

 agt aaa gaa cta cca gat tca tca tct cca gtt cca gca aac aac atc     2335
 Ser Lys Glu Leu Pro Asp Ser Ser Ser Pro Val Pro Ala Asn Asn Ile
         710                 715                 720

 cgt gtc atc aaa aat tcc att cga ctg acc ctt aat cgg taa aagcagt     2384
 Arg Val Ile Lys Asn Ser Ile Arg Leu Thr Leu Asn Arg 
     725                 730                 735

 gcctcctcac ttaagtgaac aagcaatcat ttagtggcat agatgcagcc acttgttttt   2444

 taaatagaag tggctgtcat acgtgaaata aggtgaaagt gacagccttc agtctaataa   2504

 ccttgaagtg gtttttgaac tgtcaaactt tgacctgtag atgctgtagc attctctcac   2564

 tgattgctac atacacttct ctgaggatca cctgctgtca aattgccatc tacagtatta   2624

 cagctttgca tttgggggtt ttactgcctt                                    2654




      <210> 283
      <211> 1421
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1367)

      <400> 283
 aacaacaatc tttaggtcat gcagacctcc ctgatggcat ccagaagttt caccgagggg     60

 tgcagacagt gttgatcatt ggggatgtca cctcccggat acccacctca ctc   atg     116
                                                              Met
                                                                1

 aaa gcc ccc agt tat gtg aga gtt caa gtc agt cgg ttt gtc cag aag      164
 Lys Ala Pro Ser Tyr Val Arg Val Gln Val Ser Arg Phe Val Gln Lys
               5                  10                  15

 aag gcc atg gac aga acg gag act agg ttc cgt aag agg gga cag att      212
 Lys Ala Met Asp Arg Thr Glu Thr Arg Phe Arg Lys Arg Gly Gln Ile
          20                  25                  30

 acg gga aag atc acg acc agc cgt caa ccg cac ccc cag aat gag cag      260
 Thr Gly Lys Ile Thr Thr Ser Arg Gln Pro His Pro Gln Asn Glu Gln
      35                  40                  45

 agt ccc cag cgg agc acc tcg ggg tac ccc ctc cag gag gtg gtg gat      308
 Ser Pro Gln Arg Ser Thr Ser Gly Tyr Pro Leu Gln Glu Val Val Asp
  50                  55                  60                  65

 gat gaa atg ttg gga cca tca gcc cct ggg gta gat ccc agc ccc cca      356
 Asp Glu Met Leu Gly Pro Ser Ala Pro Gly Val Asp Pro Ser Pro Pro
                  70                  75                  80

 tgt agg tcc ctt ggc tgg aaa agg aag agg gag tgg tca gat gaa tct      404
 Cys Arg Ser Leu Gly Trp Lys Arg Lys Arg Glu Trp Ser Asp Glu Ser
              85                  90                  95

 gag gag gag ccg gag aag gag ctc gcc cct gag cct gag gag acc tgg      452
 Glu Glu Glu Pro Glu Lys Glu Leu Ala Pro Glu Pro Glu Glu Thr Trp
         100                 105                 110

 gta gtg gag atg ctg tgt ggg ctc aag atg aag ctg aag caa cag cga      500
 Val Val Glu Met Leu Cys Gly Leu Lys Met Lys Leu Lys Gln Gln Arg
     115                 120                 125

 gtg tca ccc atc ctc cct gag cac cac aag gac ttc aac agt cag ctt      548
 Val Ser Pro Ile Leu Pro Glu His His Lys Asp Phe Asn Ser Gln Leu
 130                 135                 140                 145

 gcc cct ggg gta gat ccc agc ccc ccg cat agg tcc ttt tgc tgg aaa      596
 Ala Pro Gly Val Asp Pro Ser Pro Pro His Arg Ser Phe Cys Trp Lys
                 150                 155                 160

 agg aag atg gag tgg tgg gac gaa tct gag gag tcg ttg gag gag gag      644
 Arg Lys Met Glu Trp Trp Asp Glu Ser Glu Glu Ser Leu Glu Glu Glu
             165                 170                 175

 cca cgg aag gtg ctc gcc cct gag cct gag gag atc tgg gtg gcg gag      692
 Pro Arg Lys Val Leu Ala Pro Glu Pro Glu Glu Ile Trp Val Ala Glu
         180                 185                 190

 atg ctg tgt ggc ctc aag atg aag ctg aag cga cgg cga gtg tcg ctc      740
 Met Leu Cys Gly Leu Lys Met Lys Leu Lys Arg Arg Arg Val Ser Leu
     195                 200                 205

 gtg ctc cct gag cac cac gag gcc ttc aac agg ctg ctt gag gat cct      788
 Val Leu Pro Glu His His Glu Ala Phe Asn Arg Leu Leu Glu Asp Pro
 210                 215                 220                 225

 gtc att aaa aga ttc ttg gcc tgg gac aaa gat ctg agg gtg tcg gac      836
 Val Ile Lys Arg Phe Leu Ala Trp Asp Lys Asp Leu Arg Val Ser Asp
                 230                 235                 240

 aag agc cct cct gag gaa ggc atg gct ctc tgc agg gtg ggt gcc agt      884
 Lys Ser Pro Pro Glu Glu Gly Met Ala Leu Cys Arg Val Gly Ala Ser
             245                 250                 255

 cct gag cta gga acg gtc cct tac ctt cct ctc tgg gaa gct gac ctc      932
 Pro Glu Leu Gly Thr Val Pro Tyr Leu Pro Leu Trp Glu Ala Asp Leu
         260                 265                 270

 agc cgg agg tct ctc ctg gtg gtg ccc ctg agc agc aac ctg att cct      980
 Ser Arg Arg Ser Leu Leu Val Val Pro Leu Ser Ser Asn Leu Ile Pro
     275                 280                 285

 gtc ctc agc tac ctg gcc aat gac atg gag gag gac gac gag gac tcc     1028
 Val Leu Ser Tyr Leu Ala Asn Asp Met Glu Glu Asp Asp Glu Asp Ser
 290                 295                 300                 305

 aaa caa aac atc ttc cac ttc ctg tat ggg aag aac cgc tct cgc ata     1076
 Lys Gln Asn Ile Phe His Phe Leu Tyr Gly Lys Asn Arg Ser Arg Ile
                 310                 315                 320

 ccc ttg ctc cgt aag cgt cgg ttc cag tta tac cgt tcc atg aac ccg     1124
 Pro Leu Leu Arg Lys Arg Arg Phe Gln Leu Tyr Arg Ser Met Asn Pro
             325                 330                 335

 agg gcc agg aag aac cgc tct cac ata ccc ttg gtc cgt aag cgt cgg     1172
 Arg Ala Arg Lys Asn Arg Ser His Ile Pro Leu Val Arg Lys Arg Arg
         340                 345                 350

 ttc cag tta cgc cgt tgc atg aac ccg agg gcc agg aag aac cgc tct     1220
 Phe Gln Leu Arg Arg Cys Met Asn Pro Arg Ala Arg Lys Asn Arg Ser
     355                 360                 365

 cag ata gtc ctg ttc cag aaa cgt cgg ttc cac ttc ttc tgt tcc atg     1268
 Gln Ile Val Leu Phe Gln Lys Arg Arg Phe His Phe Phe Cys Ser Met
 370                 375                 380                 385

 agc tgc agg gct tgg gtt tcc cca gag gag ttg gag gag atc cag gct     1316
 Ser Cys Arg Ala Trp Val Ser Pro Glu Glu Leu Glu Glu Ile Gln Ala
                 390                 395                 400

 tat gac cca gag cac tgg gtg tgg gcg cga gat cgc gct cgc ctt tcc     1364
 Tyr Asp Pro Glu His Trp Val Trp Ala Arg Asp Arg Ala Arg Leu Ser
             405                 410                 415

 tag agct ccagggacca tggaggcctg aggtcatcgg cctgagagaa gaacaccgga     1421
 






      <210> 284
      <211> 6201
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(6147)

      <400> 284
  atg tcc aag caa gag cct ttt cca aac cct gaa gcc cca aga gac tca      48
  Met Ser Lys Gln Glu Pro Phe Pro Asn Pro Glu Ala Pro Arg Asp Ser
    1               5                  10                  15

 cca tct ggg gaa agt gtg gcc ttt tgt tct cct act tta gaa agg cga       96
 Pro Ser Gly Glu Ser Val Ala Phe Cys Ser Pro Thr Leu Glu Arg Arg
              20                  25                  30

 tac ttc cag cta cac agg cct tat ttc tgt tcc ttg ctt ctt ccc ttg      144
 Tyr Phe Gln Leu His Arg Pro Tyr Phe Cys Ser Leu Leu Leu Pro Leu
          35                  40                  45

 ggg cac ttg ttg ctc tac aga ggc tac ccc tct gcc tgg aaa gct ctc      192
 Gly His Leu Leu Leu Tyr Arg Gly Tyr Pro Ser Ala Trp Lys Ala Leu
      50                  55                  60

 tct cag acc ctt ctg cca cga ccc ttt ggc ctc atc ctt cat cct tca      240
 Ser Gln Thr Leu Leu Pro Arg Pro Phe Gly Leu Ile Leu His Pro Ser
  65                  70                  75                  80

 ttc ttc cag ccc tat gtc atc tca gag aaa tct tca ctg gtg gtg cct      288
 Phe Phe Gln Pro Tyr Val Ile Ser Glu Lys Ser Ser Leu Val Val Pro
                  85                  90                  95

 cag ccc agc aaa ctt cag aag aca aag agg gat atc aga tgg ctt cag      336
 Gln Pro Ser Lys Leu Gln Lys Thr Lys Arg Asp Ile Arg Trp Leu Gln
             100                 105                 110

 gga gtg act ggt gaa tgg ttt gaa gaa att caa aga aaa aag ttt tgc      384
 Gly Val Thr Gly Glu Trp Phe Glu Glu Ile Gln Arg Lys Lys Phe Cys
         115                 120                 125

 aat gaa aca gat gtt agc caa atg tta aaa caa cca ctt aca tac agg      432
 Asn Glu Thr Asp Val Ser Gln Met Leu Lys Gln Pro Leu Thr Tyr Arg
     130                 135                 140

 cta agt aag gag atg gca aaa aat gat ccg ata gaa tta cct aca tca      480
 Leu Ser Lys Glu Met Ala Lys Asn Asp Pro Ile Glu Leu Pro Thr Ser
 145                 150                 155                 160

 aga tct aaa aat gta act aat caa aaa aag ccg aca cct ttt tct tcc      528
 Arg Ser Lys Asn Val Thr Asn Gln Lys Lys Pro Thr Pro Phe Ser Ser
                 165                 170                 175

 cgg atg agc ttc aga tcg tca ttt gct tcc ctg ttc tca ttc agg aaa      576
 Arg Met Ser Phe Arg Ser Ser Phe Ala Ser Leu Phe Ser Phe Arg Lys
             180                 185                 190

 tct gga aag gag act tca aag ctt cca tca ctg gga cag aaa gga tgt      624
 Ser Gly Lys Glu Thr Ser Lys Leu Pro Ser Leu Gly Gln Lys Gly Cys
         195                 200                 205

 gat ggc cat gca gga cct cct atg cct gtg agg gga gct gct gtg cag      672
 Asp Gly His Ala Gly Pro Pro Met Pro Val Arg Gly Ala Ala Val Gln
     210                 215                 220

 gca aaa ata tac aat tca cct ctg gaa aat cat cta gtt gac agt aca      720
 Ala Lys Ile Tyr Asn Ser Pro Leu Glu Asn His Leu Val Asp Ser Thr
 225                 230                 235                 240

 ttt gtc cca aag cca gca gtc atg agg gag gag agt ggc atg cct cca      768
 Phe Val Pro Lys Pro Ala Val Met Arg Glu Glu Ser Gly Met Pro Pro
                 245                 250                 255

 ccg tgg gat gct tca ctg ctg gag aat gag ttt ttc caa gtt tta gat      816
 Pro Trp Asp Ala Ser Leu Leu Glu Asn Glu Phe Phe Gln Val Leu Asp
             260                 265                 270

 gac ttg gat agc aaa ttg gct cag gaa cag tct gca agc tca gtg aat      864
 Asp Leu Asp Ser Lys Leu Ala Gln Glu Gln Ser Ala Ser Ser Val Asn
         275                 280                 285

 acc aga aca ccc ctc aac tat gga tca aga aca cag ttc ggt cac ttt      912
 Thr Arg Thr Pro Leu Asn Tyr Gly Ser Arg Thr Gln Phe Gly His Phe
     290                 295                 300

 tat tcc agt ggt aac aga cat ggt aat atc aca gaa agg cac aaa aaa      960
 Tyr Ser Ser Gly Asn Arg His Gly Asn Ile Thr Glu Arg His Lys Lys
 305                 310                 315                 320

 cac tat aat gaa act tcc aat atg tct atc tat gac atc cta aga cca     1008
 His Tyr Asn Glu Thr Ser Asn Met Ser Ile Tyr Asp Ile Leu Arg Pro
                 325                 330                 335

 gga act cct agg gaa ggt ttt aaa acc ttt tct cct agg aca agc aca     1056
 Gly Thr Pro Arg Glu Gly Phe Lys Thr Phe Ser Pro Arg Thr Ser Thr
             340                 345                 350

 att tat gat atg tat agg aca agg gag ccc aga gtc ttt aaa gaa gat     1104
 Ile Tyr Asp Met Tyr Arg Thr Arg Glu Pro Arg Val Phe Lys Glu Asp
         355                 360                 365

 tat gtg caa aag aat act ttt ggc agt act tcg ctg tgt ttt gac agc     1152
 Tyr Val Gln Lys Asn Thr Phe Gly Ser Thr Ser Leu Cys Phe Asp Ser
     370                 375                 380

 agg caa cgg tcg gcc tta cca gcc aca ggg cat ttc aca gca aga agc     1200
 Arg Gln Arg Ser Ala Leu Pro Ala Thr Gly His Phe Thr Ala Arg Ser
 385                 390                 395                 400

 tta cat ttt cca gcc aca act cag agc aag agt ggg ttt ata cca cca     1248
 Leu His Phe Pro Ala Thr Thr Gln Ser Lys Ser Gly Phe Ile Pro Pro
                 405                 410                 415

 agg cac cag cag agt cca aag aga act cct tta tca tcc atc ata tgg     1296
 Arg His Gln Gln Ser Pro Lys Arg Thr Pro Leu Ser Ser Ile Ile Trp
             420                 425                 430

 aac aga tca gat tcc tct aga gac agg gag aac cag gaa gag ttc ctg     1344
 Asn Arg Ser Asp Ser Ser Arg Asp Arg Glu Asn Gln Glu Glu Phe Leu
         435                 440                 445

 agg gca cca tca cca atg gaa att gat ccc gct gac aag tat gtg tat     1392
 Arg Ala Pro Ser Pro Met Glu Ile Asp Pro Ala Asp Lys Tyr Val Tyr
     450                 455                 460

 ccc agg ggt ttt cag gag aat aag aga tat gaa tcg tac cat tca cag     1440
 Pro Arg Gly Phe Gln Glu Asn Lys Arg Tyr Glu Ser Tyr His Ser Gln
 465                 470                 475                 480

 aat gtt tac caa cgt gtt agt tta aat gct ccc atg gag aat gca atg     1488
 Asn Val Tyr Gln Arg Val Ser Leu Asn Ala Pro Met Glu Asn Ala Met
                 485                 490                 495

 agt ccc gac act ttt gag aac tca gag aac atg cca ttc tac cat caa     1536
 Ser Pro Asp Thr Phe Glu Asn Ser Glu Asn Met Pro Phe Tyr His Gln
             500                 505                 510

 agc aac aca ttt acc aga tct ttc ttc agc aat acc ttt gga cga agc     1584
 Ser Asn Thr Phe Thr Arg Ser Phe Phe Ser Asn Thr Phe Gly Arg Ser
         515                 520                 525

 gga gaa cag agg aga ttt gga caa ggt cct ttt tgg ggc caa gag aaa     1632
 Gly Glu Gln Arg Arg Phe Gly Gln Gly Pro Phe Trp Gly Gln Glu Lys
     530                 535                 540

 gga cat tct ttc tgg tct gac ttt cat cga agc agg aaa tca ttc agt     1680
 Gly His Ser Phe Trp Ser Asp Phe His Arg Ser Arg Lys Ser Phe Ser
 545                 550                 555                 560

 tct tct gac aga gac ttt gaa atg att tcc atg gaa gca aat agt gta     1728
 Ser Ser Asp Arg Asp Phe Glu Met Ile Ser Met Glu Ala Asn Ser Val
                 565                 570                 575

 tca gcc att cat ggc cat aat gtt tct tct gaa cac tgg gaa tca ttt     1776
 Ser Ala Ile His Gly His Asn Val Ser Ser Glu His Trp Glu Ser Phe
             580                 585                 590

 tct tct ggt tat gga aca gat gtt tcc aga ggc caa gaa gag cca cat     1824
 Ser Ser Gly Tyr Gly Thr Asp Val Ser Arg Gly Gln Glu Glu Pro His
         595                 600                 605

 cct tgg cag ttt gat ttt cag aga tcc aca ctg gat agc atg gtg gta     1872
 Pro Trp Gln Phe Asp Phe Gln Arg Ser Thr Leu Asp Ser Met Val Val
     610                 615                 620

 tca cat ggt aat gag acc cag ttg act cct cat ttt ggc aca cca aat     1920
 Ser His Gly Asn Glu Thr Gln Leu Thr Pro His Phe Gly Thr Pro Asn
 625                 630                 635                 640

 gtt tgc tcc atg act ggt tca agc tat cac gtc aaa tct agt gag ttg     1968
 Val Cys Ser Met Thr Gly Ser Ser Tyr His Val Lys Ser Ser Glu Leu
                 645                 650                 655

 gta agt caa cag gac agt tct cct gta gaa gta cat ata aac aaa gaa     2016
 Val Ser Gln Gln Asp Ser Ser Pro Val Glu Val His Ile Asn Lys Glu
             660                 665                 670

 gct tcc tca ttt gga att gct cag act cta gca tcc tca ttc aaa act     2064
 Ala Ser Ser Phe Gly Ile Ala Gln Thr Leu Ala Ser Ser Phe Lys Thr
         675                 680                 685

 tcc ttt tcc cag att tct gat gac aga agg aat cct cag agt ccc aac     2112
 Ser Phe Ser Gln Ile Ser Asp Asp Arg Arg Asn Pro Gln Ser Pro Asn
     690                 695                 700

 ttg cag aat ccc aca gtc act ttg cag aaa att ttt cca aat aag cct     2160
 Leu Gln Asn Pro Thr Val Thr Leu Gln Lys Ile Phe Pro Asn Lys Pro
 705                 710                 715                 720

 gcc tct cat cca atg aga agc cat aca gaa gtc act gtg acc aac agc     2208
 Ala Ser His Pro Met Arg Ser His Thr Glu Val Thr Val Thr Asn Ser
                 725                 730                 735

 aat tca gtt gac tct ctg cct ctt gcc aaa agc cag ccc aat atc ttg     2256
 Asn Ser Val Asp Ser Leu Pro Leu Ala Lys Ser Gln Pro Asn Ile Leu
             740                 745                 750

 gtc aca gaa gta aat aat gag aaa gac tta aat gaa tct att tca gaa     2304
 Val Thr Glu Val Asn Asn Glu Lys Asp Leu Asn Glu Ser Ile Ser Glu
         755                 760                 765

 gaa gac aaa cag cta agc aag atg gac cag aca aac aag gca ggt gaa     2352
 Glu Asp Lys Gln Leu Ser Lys Met Asp Gln Thr Asn Lys Ala Gly Glu
     770                 775                 780

 ata ccc caa cct gtt tca cag aca ggg atc tca aac tct tta cct gat     2400
 Ile Pro Gln Pro Val Ser Gln Thr Gly Ile Ser Asn Ser Leu Pro Asp
 785                 790                 795                 800

 ttt caa aat ccc tta tcc cag gac tca gcc aag agc aac ggg ttt ggt     2448
 Phe Gln Asn Pro Leu Ser Gln Asp Ser Ala Lys Ser Asn Gly Phe Gly
                 805                 810                 815

 ttt aat gca tct acc ata ata agt tca aaa aag tca ccc aga gtc ttt     2496
 Phe Asn Ala Ser Thr Ile Ile Ser Ser Lys Lys Ser Pro Arg Val Phe
             820                 825                 830

 tcc agg aaa gat acc tcc aaa atg tat ata ccg cac aca gat aaa tcc     2544
 Ser Arg Lys Asp Thr Ser Lys Met Tyr Ile Pro His Thr Asp Lys Ser
         835                 840                 845

 aat gac att aaa caa gat aag agg ttt act gaa aac aga aaa ctt ggc     2592
 Asn Asp Ile Lys Gln Asp Lys Arg Phe Thr Glu Asn Arg Lys Leu Gly
     850                 855                 860

 tca aca gct tcc ctt cct ttc att cag gaa cac aga aca cca cca tct     2640
 Ser Thr Ala Ser Leu Pro Phe Ile Gln Glu His Arg Thr Pro Pro Ser
 865                 870                 875                 880

 ttc ccc agg aca gac caa ggt tgt cac cag gaa tta act gta aat aat     2688
 Phe Pro Arg Thr Asp Gln Gly Cys His Gln Glu Leu Thr Val Asn Asn
                 885                 890                 895

 gaa gat att tca aga att att aca aat aac cac tgg agc tct gca ctg     2736
 Glu Asp Ile Ser Arg Ile Ile Thr Asn Asn His Trp Ser Ser Ala Leu
             900                 905                 910

 act gat act caa aat gca caa tac tca aaa tgc aag tta act cct ggc     2784
 Thr Asp Thr Gln Asn Ala Gln Tyr Ser Lys Cys Lys Leu Thr Pro Gly
         915                 920                 925

 cac aag acc tcg tgt gat tct tta gat ctg tca tca gct gca cta cca     2832
 His Lys Thr Ser Cys Asp Ser Leu Asp Leu Ser Ser Ala Ala Leu Pro
     930                 935                 940

 gat tcc tca cca tca aag aat tct tcc ctt gat gct cct gtg gtt cca     2880
 Asp Ser Ser Pro Ser Lys Asn Ser Ser Leu Asp Ala Pro Val Val Pro
 945                 950                 955                 960

 tct act aca gtg ttc tcc agg aga agt cct tca gac aaa gat cca tcg     2928
 Ser Thr Thr Val Phe Ser Arg Arg Ser Pro Ser Asp Lys Asp Pro Ser
                 965                 970                 975

 cta gga gaa aga gaa gaa aaa gac aat gct ggg aag aac caa aag aat     2976
 Leu Gly Glu Arg Glu Glu Lys Asp Asn Ala Gly Lys Asn Gln Lys Asn
             980                 985                 990

 cag ttt att gta agc cac tca gaa aac caa gag aga aat gat agt cct     3024
 Gln Phe Ile Val Ser His Ser Glu Asn Gln Glu Arg Asn Asp Ser Pro
         995                1000                1005

 gtg cct aca cat gat gaa gtg gtt gat gtc aaa tgc cat tca cac tct     3072
 Val Pro Thr His Asp Glu Val Val Asp Val Lys Cys His Ser His Ser
    1010                1015                1020

 cct ttt agg aat gaa aga gga aaa gga aaa ata agg cat cat ata tcc     3120
 Pro Phe Arg Asn Glu Arg Gly Lys Gly Lys Ile Arg His His Ile Ser
1025                1030                1035                1040

 tgt att gaa aag tta agc aaa aca gaa agt ata tca gta ccc acc agt     3168
 Cys Ile Glu Lys Leu Ser Lys Thr Glu Ser Ile Ser Val Pro Thr Ser
                1045                1050                1055

 gat cac agg agc ctc att gaa gca aat caa agc aat tcc aaa gtt tct     3216
 Asp His Arg Ser Leu Ile Glu Ala Asn Gln Ser Asn Ser Lys Val Ser
            1060                1065                1070

 gaa ctt gac aca att tat tgt acc ttg cca aga aaa tca agc agt ttt     3264
 Glu Leu Asp Thr Ile Tyr Cys Thr Leu Pro Arg Lys Ser Ser Ser Phe
        1075                1080                1085

 ctc ata cat ggc agg cag tca gga agt aaa ata atg gct gct tca ttg     3312
 Leu Ile His Gly Arg Gln Ser Gly Ser Lys Ile Met Ala Ala Ser Leu
    1090                1095                1100

 agg aat ggg cca cct ccc ttc caa atc aaa aat aat gtg gaa gat gca     3360
 Arg Asn Gly Pro Pro Pro Phe Gln Ile Lys Asn Asn Val Glu Asp Ala
1105                1110                1115                1120

 atg ggg aac tat atg tta aac aaa ttt agt ccc agt tct cct gag tca     3408
 Met Gly Asn Tyr Met Leu Asn Lys Phe Ser Pro Ser Ser Pro Glu Ser
                1125                1130                1135

 gcg aat gaa tgt tcc aaa gtc ctt tca gac tca gcc ctg gaa gca cct     3456
 Ala Asn Glu Cys Ser Lys Val Leu Ser Asp Ser Ala Leu Glu Ala Pro
            1140                1145                1150

 gaa gcc aca gag aga atg aca aat gta aaa agc agt gga tct act tcc     3504
 Glu Ala Thr Glu Arg Met Thr Asn Val Lys Ser Ser Gly Ser Thr Ser
        1155                1160                1165

 gtt aga aaa gga cca ctt cca ttc ctc atc aac agg gct atg tca tgt     3552
 Val Arg Lys Gly Pro Leu Pro Phe Leu Ile Asn Arg Ala Met Ser Cys
    1170                1175                1180

 ccc tca ggg gag cca cat gcc tca act gga aga gaa gga aga aaa aag     3600
 Pro Ser Gly Glu Pro His Ala Ser Thr Gly Arg Glu Gly Arg Lys Lys
1185                1190                1195                1200

 cca ttg acc tca ggc atg gat gct tct gag cta aca cca agg gct tgg     3648
 Pro Leu Thr Ser Gly Met Asp Ala Ser Glu Leu Thr Pro Arg Ala Trp
                1205                1210                1215

 gag aga atc att agc cct gtg gaa agt gac tca tct gtt aga gat tgt     3696
 Glu Arg Ile Ile Ser Pro Val Glu Ser Asp Ser Ser Val Arg Asp Cys
            1220                1225                1230

 tct tta acc aaa aga caa cac caa aag gaa aac ttc caa gaa tac act     3744
 Ser Leu Thr Lys Arg Gln His Gln Lys Glu Asn Phe Gln Glu Tyr Thr
        1235                1240                1245

 gag aaa gag ggt aaa atg gct gcc tcc agg aga agt gta ttt gct ctt     3792
 Glu Lys Glu Gly Lys Met Ala Ala Ser Arg Arg Ser Val Phe Ala Leu
    1250                1255                1260

 tca aat gaa gac cct tta cct ttt tgc tca gac ttg tca gga aaa gaa     3840
 Ser Asn Glu Asp Pro Leu Pro Phe Cys Ser Asp Leu Ser Gly Lys Glu
1265                1270                1275                1280

 cgt ggg aaa aca tta cat aaa gtt aag acg act agt acg ttt tct gtt     3888
 Arg Gly Lys Thr Leu His Lys Val Lys Thr Thr Ser Thr Phe Ser Val
                1285                1290                1295

 tct ggt gat gaa gat aat gta aaa tgt ctg gag gtg gtc tca ata tat     3936
 Ser Gly Asp Glu Asp Asn Val Lys Cys Leu Glu Val Val Ser Ile Tyr
            1300                1305                1310

 tac act cta ccg agg aaa ccc agc aaa aaa ttc tgt aac ctc ctt caa     3984
 Tyr Thr Leu Pro Arg Lys Pro Ser Lys Lys Phe Cys Asn Leu Leu Gln
        1315                1320                1325

 cag tat aca caa aat act aat tta ctt ata gaa tca cct caa gtg gag     4032
 Gln Tyr Thr Gln Asn Thr Asn Leu Leu Ile Glu Ser Pro Gln Val Glu
    1330                1335                1340

 act gaa aca ttt cct aac gct tta gaa aaa gac aaa cag aat tat tct     4080
 Thr Glu Thr Phe Pro Asn Ala Leu Glu Lys Asp Lys Gln Asn Tyr Ser
1345                1350                1355                1360

 aca cga gag cag tca gga aca cct tca tgt gaa aat cta aag atg tcc     4128
 Thr Arg Glu Gln Ser Gly Thr Pro Ser Cys Glu Asn Leu Lys Met Ser
                1365                1370                1375

 gtc aac tct gat cag acg ctc acc act gaa aat atg act gcc ttc cga     4176
 Val Asn Ser Asp Gln Thr Leu Thr Thr Glu Asn Met Thr Ala Phe Arg
            1380                1385                1390

 tta tca aat agg ggg ccc cta gct cct aca tta cag gaa atg gct tct     4224
 Leu Ser Asn Arg Gly Pro Leu Ala Pro Thr Leu Gln Glu Met Ala Ser
        1395                1400                1405

 gtt gag gca gct gtt tct ctt cct gaa gag gaa tct aaa gct aga gag     4272
 Val Glu Ala Ala Val Ser Leu Pro Glu Glu Glu Ser Lys Ala Arg Glu
    1410                1415                1420

 att ttt tca gat aat tta gct aaa aca cct cta ggt gat tca gaa aac     4320
 Ile Phe Ser Asp Asn Leu Ala Lys Thr Pro Leu Gly Asp Ser Glu Asn
1425                1430                1435                1440

 aag aag gaa aga ggc aaa aag ttg caa agt gaa acc ctg cat act tca     4368
 Lys Lys Glu Arg Gly Lys Lys Leu Gln Ser Glu Thr Leu His Thr Ser
                1445                1450                1455

 ttg atg ctt cag aga aaa aat gta tcc gaa gaa aaa tct gaa aat tgt     4416
 Leu Met Leu Gln Arg Lys Asn Val Ser Glu Glu Lys Ser Glu Asn Cys
            1460                1465                1470

 caa caa tcc att aat tca agt aac agt ggt ccc tct agt ctt cca gct     4464
 Gln Gln Ser Ile Asn Ser Ser Asn Ser Gly Pro Ser Ser Leu Pro Ala
        1475                1480                1485

 ctt tca gaa gtt aat att gga aat tcc caa act aga aga agt tct tgg     4512
 Leu Ser Glu Val Asn Ile Gly Asn Ser Gln Thr Arg Arg Ser Ser Trp
    1490                1495                1500

 gag tgt aca ggg agt ggt aga gcc att cca ttt act gga agt ggc aag     4560
 Glu Cys Thr Gly Ser Gly Arg Ala Ile Pro Phe Thr Gly Ser Gly Lys
1505                1510                1515                1520

 tgt ccc cag aaa gat cac aca tcc aca gct gta ggt gat ggc tcc agt     4608
 Cys Pro Gln Lys Asp His Thr Ser Thr Ala Val Gly Asp Gly Ser Ser
                1525                1530                1535

 gga tca cag cct agg gaa ggc aga ggg gac att gga acc aac tgc caa     4656
 Gly Ser Gln Pro Arg Glu Gly Arg Gly Asp Ile Gly Thr Asn Cys Gln
            1540                1545                1550

 aaa atg act aat aaa aca ctt tct cac tca gag agt caa gtc ttt gcc     4704
 Lys Met Thr Asn Lys Thr Leu Ser His Ser Glu Ser Gln Val Phe Ala
        1555                1560                1565

 ctt act cca gca ttg cat aaa cta cag ctt ggt gag gag act cag tca     4752
 Leu Thr Pro Ala Leu His Lys Leu Gln Leu Gly Glu Glu Thr Gln Ser
    1570                1575                1580

 gat gaa cca aac tta gag agt ctg cag tct gaa cca aga gaa tta cct     4800
 Asp Glu Pro Asn Leu Glu Ser Leu Gln Ser Glu Pro Arg Glu Leu Pro
1585                1590                1595                1600

 caa aga agt cag gag gca aat atg aca gag agc agg aag gct gaa gat     4848
 Gln Arg Ser Gln Glu Ala Asn Met Thr Glu Ser Arg Lys Ala Glu Asp
                1605                1610                1615

 gaa atg cag aag tca gct tgg gat caa cct tca ctt cct gaa gga aac     4896
 Glu Met Gln Lys Ser Ala Trp Asp Gln Pro Ser Leu Pro Glu Gly Asn
            1620                1625                1630

 aaa aat aaa acc aac ttg gat gac cta gta aag ggg gaa aat aga tct     4944
 Lys Asn Lys Thr Asn Leu Asp Asp Leu Val Lys Gly Glu Asn Arg Ser
        1635                1640                1645

 tca gtt aaa cac aga ttg gca gcc atg tct aaa gcc agc aga aaa ttc     4992
 Ser Val Lys His Arg Leu Ala Ala Met Ser Lys Ala Ser Arg Lys Phe
    1650                1655                1660

 cca gct aaa gat gta agc ccc aga aga cat gta gct act atc ttc ccc     5040
 Pro Ala Lys Asp Val Ser Pro Arg Arg His Val Ala Thr Ile Phe Pro
1665                1670                1675                1680

 caa agt gga agc aga tct ggc ttt gac cat tta tct ctt ggc aca gtg     5088
 Gln Ser Gly Ser Arg Ser Gly Phe Asp His Leu Ser Leu Gly Thr Val
                1685                1690                1695

 gag tgc aac cca ctg ttc cct gag cct act cca aaa tct gca gag tcc     5136
 Glu Cys Asn Pro Leu Phe Pro Glu Pro Thr Pro Lys Ser Ala Glu Ser
            1700                1705                1710

 att ggc gaa agc agg ttg agt gag aac gga aag cat gtg aag aaa tcc     5184
 Ile Gly Glu Ser Arg Leu Ser Glu Asn Gly Lys His Val Lys Lys Ser
        1715                1720                1725

 gag aac ctt ctc ccc att act gta cta ccc aac aga gaa cct tct aca     5232
 Glu Asn Leu Leu Pro Ile Thr Val Leu Pro Asn Arg Glu Pro Ser Thr
    1730                1735                1740

 cac gtc agc aac cag aag tct aac agc att tca caa cga cat cag aat     5280
 His Val Ser Asn Gln Lys Ser Asn Ser Ile Ser Gln Arg His Gln Asn
1745                1750                1755                1760

 gag ttt aaa aac gtc tca gaa tca cca tca aag cat gag aat tct aaa     5328
 Glu Phe Lys Asn Val Ser Glu Ser Pro Ser Lys His Glu Asn Ser Lys
                1765                1770                1775

 gac gtc aca gca gct cag aat tta gta aga gaa tca gga gcc cca tca     5376
 Asp Val Thr Ala Ala Gln Asn Leu Val Arg Glu Ser Gly Ala Pro Ser
            1780                1785                1790

 ccc atc aca ttc acc agc ctc agg gaa gca gaa ttc tct gac aat cag     5424
 Pro Ile Thr Phe Thr Ser Leu Arg Glu Ala Glu Phe Ser Asp Asn Gln
        1795                1800                1805

 agg agg ctg agc cct cct ttt cca ctg gag cct gca cag aaa tct aga     5472
 Arg Arg Leu Ser Pro Pro Phe Pro Leu Glu Pro Ala Gln Lys Ser Arg
    1810                1815                1820

 gta agc agt cca ctg gcc agt ttt ctg cag caa caa agg agt gct tca     5520
 Val Ser Ser Pro Leu Ala Ser Phe Leu Gln Gln Gln Arg Ser Ala Ser
1825                1830                1835                1840

 tct ctg gag tgg gaa cct gag cca cac ctc tat cgt tca aag agt tta     5568
 Ser Leu Glu Trp Glu Pro Glu Pro His Leu Tyr Arg Ser Lys Ser Leu
                1845                1850                1855

 aaa agc att aat gtt cat ggc gat cta cta cga aaa agc cat cct cca     5616
 Lys Ser Ile Asn Val His Gly Asp Leu Leu Arg Lys Ser His Pro Pro
            1860                1865                1870

 aaa gtc agg gag cgc cat ttt tct gaa agc act tct att gac aat gcc     5664
 Lys Val Arg Glu Arg His Phe Ser Glu Ser Thr Ser Ile Asp Asn Ala
        1875                1880                1885

 ctg agt cga ctg acc ctt ggg aat gaa ttc tct gtc aac aat ggg tac     5712
 Leu Ser Arg Leu Thr Leu Gly Asn Glu Phe Ser Val Asn Asn Gly Tyr
    1890                1895                1900

 agt cga aga ttc aga tct ttt tct gaa ctc ccc tcc tgt gat gga aat     5760
 Ser Arg Arg Phe Arg Ser Phe Ser Glu Leu Pro Ser Cys Asp Gly Asn
1905                1910                1915                1920

 gaa agt tgg gct tat cgc agc ggg aca aaa aca ggt ccc agg tct gca     5808
 Glu Ser Trp Ala Tyr Arg Ser Gly Thr Lys Thr Gly Pro Arg Ser Ala
                1925                1930                1935

 ata tct ata tac aga cct atc gac tat ggg atc ttt ggg aaa gaa caa     5856
 Ile Ser Ile Tyr Arg Pro Ile Asp Tyr Gly Ile Phe Gly Lys Glu Gln
            1940                1945                1950

 cag tta gct ttc tta gaa aat gta aag agg tca ctt aca caa gga aga     5904
 Gln Leu Ala Phe Leu Glu Asn Val Lys Arg Ser Leu Thr Gln Gly Arg
        1955                1960                1965

 tta tgg aaa cca agt ttt ctt aag aac cct ggc ttc cta aaa gat gat     5952
 Leu Trp Lys Pro Ser Phe Leu Lys Asn Pro Gly Phe Leu Lys Asp Asp
    1970                1975                1980

 ttg agg aac cct ccc aac ccc tca gag tca tta agc tca aat tct ccc     6000
 Leu Arg Asn Pro Pro Asn Pro Ser Glu Ser Leu Ser Ser Asn Ser Pro
1985                1990                1995                2000

 agt agt cag gtg cca gaa gat ggc tta tct cca agt gaa ccg ctt aat     6048
 Ser Ser Gln Val Pro Glu Asp Gly Leu Ser Pro Ser Glu Pro Leu Asn
                2005                2010                2015

 atc tat gag gat gac cca gtg gac tca gat tgt gac aca gac aca acc     6096
 Ile Tyr Glu Asp Asp Pro Val Asp Ser Asp Cys Asp Thr Asp Thr Thr
            2020                2025                2030

 aca gat gat gaa tac tac ctg gat gaa aat gac aaa gag tca gaa ctg     6144
 Thr Asp Asp Glu Tyr Tyr Leu Asp Glu Asn Asp Lys Glu Ser Glu Leu
        2035                2040                2045

 tga ggct ttttcaataa aatgctttac ttttttcacc aaaagcttat aatggaacta     6201
 






      <210> 285
      <211> 3206
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(3075)

      <400> 285
 tttcgtggct ccggg atg tcc gcg ctg tgc gac cct ccc ggg gcc cca ggg      51
                  Met Ser Ala Leu Cys Asp Pro Pro Gly Ala Pro Gly
                    1               5                  10

 cca cct ggg cct gcc ccg gcc acc cac ggt ccc gcg cct ctc agt gct       99
 Pro Pro Gly Pro Ala Pro Ala Thr His Gly Pro Ala Pro Leu Ser Ala
          15                  20                  25

 cag gag ctg tcc cag gaa atc aag gct ttt ctg act ggc gta gac ccc      147
 Gln Glu Leu Ser Gln Glu Ile Lys Ala Phe Leu Thr Gly Val Asp Pro
      30                  35                  40

 att ctg ggc cac caa ctc tca gcc cgg gaa cat gct cgc tgt ggt ctt      195
 Ile Leu Gly His Gln Leu Ser Ala Arg Glu His Ala Arg Cys Gly Leu
  45                  50                  55                  60

 ctc ctg ctc cgt tct ttg cca cct gct cgg gct gct gtg ctt gac cac      243
 Leu Leu Leu Arg Ser Leu Pro Pro Ala Arg Ala Ala Val Leu Asp His
                  65                  70                  75

 ttg aga ggt gtc ttt gat gag agt gtc cgg gcc cac ctg gct gcc ctg      291
 Leu Arg Gly Val Phe Asp Glu Ser Val Arg Ala His Leu Ala Ala Leu
              80                  85                  90

 gat gaa acc cct gtg gct ggt cca cct cac ctc cgt cca cct cca ccc      339
 Asp Glu Thr Pro Val Ala Gly Pro Pro His Leu Arg Pro Pro Pro Pro
          95                 100                 105

 tct cat gtc cct gct ggt gga cct ggt cta gag gat gtg gtt cag gaa      387
 Ser His Val Pro Ala Gly Gly Pro Gly Leu Glu Asp Val Val Gln Glu
     110                 115                 120

 gtg cag cag gtg ctg tct gag ttt atc cgg gcc aac cca aag gcc tgg      435
 Val Gln Gln Val Leu Ser Glu Phe Ile Arg Ala Asn Pro Lys Ala Trp
 125                 130                 135                 140

 gca cct gtg att agt gca tgg tcc att gac ctc atg ggg caa ctg agc      483
 Ala Pro Val Ile Ser Ala Trp Ser Ile Asp Leu Met Gly Gln Leu Ser
                 145                 150                 155

 agc acg tac tca ggc cag cac cag cgt gtt ccc cac gct act ggc gct      531
 Ser Thr Tyr Ser Gly Gln His Gln Arg Val Pro His Ala Thr Gly Ala
             160                 165                 170

 ctt aat gaa ctg cta cag ctg tgg atg ggt tgt agg gcc acg cgt aca      579
 Leu Asn Glu Leu Leu Gln Leu Trp Met Gly Cys Arg Ala Thr Arg Thr
         175                 180                 185

 tta atg gac atc tat gtg cag tgc ctc tcg gct ctc att ggt agc tgc      627
 Leu Met Asp Ile Tyr Val Gln Cys Leu Ser Ala Leu Ile Gly Ser Cys
     190                 195                 200

 cca gat gcg tgt gtg gat gcc ttg ctg gat acc tct gtt cag cat tct      675
 Pro Asp Ala Cys Val Asp Ala Leu Leu Asp Thr Ser Val Gln His Ser
 205                 210                 215                 220

 cca cac ttt gac tgg gtt gtg gca cat att ggc tcc tct ttt cct ggc      723
 Pro His Phe Asp Trp Val Val Ala His Ile Gly Ser Ser Phe Pro Gly
                 225                 230                 235

 acc atc att tcc cgg gtt ctc tcc tgt ggc ctt aag gac ttt tgt gtc      771
 Thr Ile Ile Ser Arg Val Leu Ser Cys Gly Leu Lys Asp Phe Cys Val
             240                 245                 250

 cat ggt ggg gct gga ggt gga gct ggc agt agt ggt gga agc tct tct      819
 His Gly Gly Ala Gly Gly Gly Ala Gly Ser Ser Gly Gly Ser Ser Ser
         255                 260                 265

 cag acc ccc tct aca gac ccc ttc cct gga tct cct gcc att cct gcg      867
 Gln Thr Pro Ser Thr Asp Pro Phe Pro Gly Ser Pro Ala Ile Pro Ala
     270                 275                 280

 gag aaa cgg gtg ccc aag att gcc tca gtt gta ggc atc cta ggt cac      915
 Glu Lys Arg Val Pro Lys Ile Ala Ser Val Val Gly Ile Leu Gly His
 285                 290                 295                 300

 ctg gcc tcc cgc cac gga gat agc atc cga cgg gag ctc ctg cga atg      963
 Leu Ala Ser Arg His Gly Asp Ser Ile Arg Arg Glu Leu Leu Arg Met
                 305                 310                 315

 ttc cat gat agc ctg gca ggg gga tct gga ggc cgc agt ggg gac ccc     1011
 Phe His Asp Ser Leu Ala Gly Gly Ser Gly Gly Arg Ser Gly Asp Pro
             320                 325                 330

 tcc ctt cag gcc acg gtt ccg ttc cta ctg cag ctg gca gtc atg tca     1059
 Ser Leu Gln Ala Thr Val Pro Phe Leu Leu Gln Leu Ala Val Met Ser
         335                 340                 345

 cca gct ttg ctg ggc act gtc tct gga gag ctt gtg gat tgc ctc aag     1107
 Pro Ala Leu Leu Gly Thr Val Ser Gly Glu Leu Val Asp Cys Leu Lys
     350                 355                 360

 ccc cca gct gtg ctg agc cag ctg cag caa cac ctt caa gga ttc ccc     1155
 Pro Pro Ala Val Leu Ser Gln Leu Gln Gln His Leu Gln Gly Phe Pro
 365                 370                 375                 380

 cga gag gag ctg gac aac atg ttg aac ctg gct gtg cac ctg gtg agc     1203
 Arg Glu Glu Leu Asp Asn Met Leu Asn Leu Ala Val His Leu Val Ser
                 385                 390                 395

 cag gcc tct ggg gca ggt gcc tac cgc ttg ctg cag ttc ctg gtg gac     1251
 Gln Ala Ser Gly Ala Gly Ala Tyr Arg Leu Leu Gln Phe Leu Val Asp
             400                 405                 410

 aca gct atg cct gct tcg gtc att acc acc cag ggc ctg gct gtg cca     1299
 Thr Ala Met Pro Ala Ser Val Ile Thr Thr Gln Gly Leu Ala Val Pro
         415                 420                 425

 gac acc gtg cgt gag gct tgt gac cgg cta atc cag ctg ctg ctg ctg     1347
 Asp Thr Val Arg Glu Ala Cys Asp Arg Leu Ile Gln Leu Leu Leu Leu
     430                 435                 440

 cac ctg caa aaa ctg gtt cat cac cgg gga ggg tct cct ggg gaa ggg     1395
 His Leu Gln Lys Leu Val His His Arg Gly Gly Ser Pro Gly Glu Gly
 445                 450                 455                 460

 gtg cta ggc ccg ccc cca cct ccc cgc ttg gtg ccc ttt tta gat gcg     1443
 Val Leu Gly Pro Pro Pro Pro Pro Arg Leu Val Pro Phe Leu Asp Ala
                 465                 470                 475

 ctc aaa aac cat gtt gga gag ctg tgt gga gag acg tta cga ttg gaa     1491
 Leu Lys Asn His Val Gly Glu Leu Cys Gly Glu Thr Leu Arg Leu Glu
             480                 485                 490

 cgg aag cgc ttc ctc tgg cag cac cag ctc ttg ggc ctg ctg tct gtc     1539
 Arg Lys Arg Phe Leu Trp Gln His Gln Leu Leu Gly Leu Leu Ser Val
         495                 500                 505

 tat acc cgg cct agc tgt gga cct gag gcc ttg ggc cat ctg ctg agc     1587
 Tyr Thr Arg Pro Ser Cys Gly Pro Glu Ala Leu Gly His Leu Leu Ser
     510                 515                 520

 cga gcc cga agc cct gaa gag ttg agt ttg gcc acc cag tta tat gca     1635
 Arg Ala Arg Ser Pro Glu Glu Leu Ser Leu Ala Thr Gln Leu Tyr Ala
 525                 530                 535                 540

 ggg cta gtg gtc agc ctc tct ggc ctc ctg ccc ctg gct ttc cga agc     1683
 Gly Leu Val Val Ser Leu Ser Gly Leu Leu Pro Leu Ala Phe Arg Ser
                 545                 550                 555

 tgt ctg gct cgg gtg cat gca ggg aca tta cag cct ccc ttc acg gcc     1731
 Cys Leu Ala Arg Val His Ala Gly Thr Leu Gln Pro Pro Phe Thr Ala
             560                 565                 570

 cgg ttc ctg cgc aac ttg gca ctg cta gta ggg tgg gaa cag cag ggt     1779
 Arg Phe Leu Arg Asn Leu Ala Leu Leu Val Gly Trp Glu Gln Gln Gly
         575                 580                 585

 ggc gag ggc cct gca gcc cta ggg gcg cac ttt ggg gaa tct gcc tca     1827
 Gly Glu Gly Pro Ala Ala Leu Gly Ala His Phe Gly Glu Ser Ala Ser
     590                 595                 600

 gcc cat ctg tct gac ctg gct cct ctc ctg cta cat cct gag gag gaa     1875
 Ala His Leu Ser Asp Leu Ala Pro Leu Leu Leu His Pro Glu Glu Glu
 605                 610                 615                 620

 gta gct gaa gct gct gcc tct ctc ctg gcc att tgt ccc ttt cct tct     1923
 Val Ala Glu Ala Ala Ala Ser Leu Leu Ala Ile Cys Pro Phe Pro Ser
                 625                 630                 635

 gaa gcc tta tcc ccc tcc cag ctc ctg gga ctg gta agg gct ggg gtg     1971
 Glu Ala Leu Ser Pro Ser Gln Leu Leu Gly Leu Val Arg Ala Gly Val
             640                 645                 650

 cac cgc ttc ttt gcc tct ctg agg ctg cat gga ccc cca ggt gtg gcc     2019
 His Arg Phe Phe Ala Ser Leu Arg Leu His Gly Pro Pro Gly Val Ala
         655                 660                 665

 tca gcc tgt cag ctt ctc acc cgc ctg tct cag aca tcc cca gct ggg     2067
 Ser Ala Cys Gln Leu Leu Thr Arg Leu Ser Gln Thr Ser Pro Ala Gly
     670                 675                 680

 ctc aag gct gtc ctg cag ctg ctg gtt gaa gga gcc tta cat cga ggc     2115
 Leu Lys Ala Val Leu Gln Leu Leu Val Glu Gly Ala Leu His Arg Gly
 685                 690                 695                 700

 aac aca gaa ctg ttt ggt ggg caa gta gat ggg gac aat gag act ctc     2163
 Asn Thr Glu Leu Phe Gly Gly Gln Val Asp Gly Asp Asn Glu Thr Leu
                 705                 710                 715

 tca gtt gtt tca gct tct ttg gct tct gcc tcc ctg ttg gac act aac     2211
 Ser Val Val Ser Ala Ser Leu Ala Ser Ala Ser Leu Leu Asp Thr Asn
             720                 725                 730

 cgg agg cac act gca gct gtg cca ggt cct gga ggg att tgg tca gtt     2259
 Arg Arg His Thr Ala Ala Val Pro Gly Pro Gly Gly Ile Trp Ser Val
         735                 740                 745

 ttc cat gct gga gtc atc ggc cgt ggc tta aag cca ccc aag ttt gtc     2307
 Phe His Ala Gly Val Ile Gly Arg Gly Leu Lys Pro Pro Lys Phe Val
     750                 755                 760

 cag tca cga aat cag cag gaa gtg atc tat aac acc cag agc ctc ctc     2355
 Gln Ser Arg Asn Gln Gln Glu Val Ile Tyr Asn Thr Gln Ser Leu Leu
 765                 770                 775                 780

 agc ctc ctg gtt cac tgc tgc agt gcc cca ggg ggc act gaa tgt ggg     2403
 Ser Leu Leu Val His Cys Cys Ser Ala Pro Gly Gly Thr Glu Cys Gly
                 785                 790                 795

 gaa tgc tgg ggg gca ccc atc ttg agt cca gag gca gcc aaa gca gtg     2451
 Glu Cys Trp Gly Ala Pro Ile Leu Ser Pro Glu Ala Ala Lys Ala Val
             800                 805                 810

 gca gtg acc ttg gtg gag agt gtg tgt ccc gat gca gct ggt gca gag     2499
 Ala Val Thr Leu Val Glu Ser Val Cys Pro Asp Ala Ala Gly Ala Glu
         815                 820                 825

 ctg gcc tgg ccc ccc gag gaa cac gcc cgg gcc acc gtg gag cgg gat     2547
 Leu Ala Trp Pro Pro Glu Glu His Ala Arg Ala Thr Val Glu Arg Asp
     830                 835                 840

 ctc cgc att ggc cgg cgc ttc cgc gaa cag ccc ctg ctc ttt gag ctg     2595
 Leu Arg Ile Gly Arg Arg Phe Arg Glu Gln Pro Leu Leu Phe Glu Leu
 845                 850                 855                 860

 tta aag ctg gta gca gct gca ccc cca gcc ctg tgc tac tgt tcc gtg     2643
 Leu Lys Leu Val Ala Ala Ala Pro Pro Ala Leu Cys Tyr Cys Ser Val
                 865                 870                 875

 ctg ctt cgg ggg ctg ctg gcc gcc ctc ttg ggc cat tgg gaa gcc tct     2691
 Leu Leu Arg Gly Leu Leu Ala Ala Leu Leu Gly His Trp Glu Ala Ser
             880                 885                 890

 cgc cac cct gac acg acc cac tcc ccc tgg cac ctg gag gca tcc tgc     2739
 Arg His Pro Asp Thr Thr His Ser Pro Trp His Leu Glu Ala Ser Cys
         895                 900                 905

 acc tta gtg gct gtc atg gct gag gga agc ctc ctg cct ccg gcc ctg     2787
 Thr Leu Val Ala Val Met Ala Glu Gly Ser Leu Leu Pro Pro Ala Leu
     910                 915                 920

 ggt aat atg cat gaa gta ttt agc caa ctg gca cct ttc gag gtg cgt     2835
 Gly Asn Met His Glu Val Phe Ser Gln Leu Ala Pro Phe Glu Val Arg
 925                 930                 935                 940

 ctg ctg ctg ctc agt gtc tgg ggt ttt ctc cgg gag cat ggg ccc ttg     2883
 Leu Leu Leu Leu Ser Val Trp Gly Phe Leu Arg Glu His Gly Pro Leu
                 945                 950                 955

 cct cag aag ttc atc ttc caa tca gag cgg ggt cgc ttc att cgg gac     2931
 Pro Gln Lys Phe Ile Phe Gln Ser Glu Arg Gly Arg Phe Ile Arg Asp
             960                 965                 970

 ttc tcc agg gag ggt gga ggt gag ggt gga ccc cat ctg gct gtg ctg     2979
 Phe Ser Arg Glu Gly Gly Gly Glu Gly Gly Pro His Leu Ala Val Leu
         975                 980                 985

 cac agt gtc ctc cac cgc aac atc gac cgc cta ggt ctt ttc tct ggc     3027
 His Ser Val Leu His Arg Asn Ile Asp Arg Leu Gly Leu Phe Ser Gly
     990                 995                1000

 cgt ttc cag gca cct tca ccg tcc act ctc ctt cga cag ggg acg tag     3075
 Arg Phe Gln Ala Pro Ser Pro Ser Thr Leu Leu Arg Gln Gly Thr 
1005                1010                1015

 ccttttcttg ctctggaagc ccagggaggt tgagcagtga gagagggaag ggactaacgt   3135

 gctccggaag ggtggaggtt tctcttctaa gtccttggtc taaagagcgc tgtcactttt   3195

 ttctctccca c                                                        3206




      <210> 286
      <211> 2011
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (456)..(1826)

      <400> 286
 ctgtatatgg aatctgtgac tgttcttcca agcggggact tgaggagtct gagcttgata     60

 aagagagcca gctggtcacc ccgggccatt ttcttccatc tggtttaggt gcatatggcc    120

 tcctgctggc cattctgatc gacgtcatcc aagatggagt cgcagccggg ccttctggga    180

 agcgtagttc tggagtaggg ctagggaaac gttctgcgca tgtgcagtgt cttctttctg    240

 gcattggcgt ttttttggtc ttacgcccta gggtggggag aggactccgg tgcctccggg    300

 tctgggctgg gccgcaaagg gcggggcctg ggcccggcgc gggccgggag cagaggccga    360

 gaccctgcag gtgattcctg gggctgccag ctaaggtccc ttatgatttc tgctctggct    420

 ttgcagtttt cagcctttcc caagagcagc agaaa   atg aac aag ttc cag gga     473
                                          Met Asn Lys Phe Gln Gly
                                            1               5

 ccc atg aca tta aag gat gtt att gtg gaa ttc acc aag gaa gaa tgg      521
 Pro Met Thr Leu Lys Asp Val Ile Val Glu Phe Thr Lys Glu Glu Trp
              10                  15                  20

 aag tta ctg acc cct gct cag agg act ctg tat aag gat gtg atg ctg      569
 Lys Leu Leu Thr Pro Ala Gln Arg Thr Leu Tyr Lys Asp Val Met Leu
          25                  30                  35

 gaa aac tat agt cac ctt gtc tca gtg ggt tac cat gtg aat aag cca      617
 Glu Asn Tyr Ser His Leu Val Ser Val Gly Tyr His Val Asn Lys Pro
      40                  45                  50

 aat gca gtc ttc aag ttg aag caa gga aaa gag cca tgg ata tta gaa      665
 Asn Ala Val Phe Lys Leu Lys Gln Gly Lys Glu Pro Trp Ile Leu Glu
  55                  60                  65                  70

 gta gaa ttt cca cat cgg ggc ttc cct gaa gac cta tgg agc att cat      713
 Val Glu Phe Pro His Arg Gly Phe Pro Glu Asp Leu Trp Ser Ile His
                  75                  80                  85

 gat cta gaa gca aga tac cag gaa agc caa gct gga aat tca agg aat      761
 Asp Leu Glu Ala Arg Tyr Gln Glu Ser Gln Ala Gly Asn Ser Arg Asn
              90                  95                 100

 gga gaa ctc aca aaa cat cag aaa act cat acc aca gag aaa gcc tgt      809
 Gly Glu Leu Thr Lys His Gln Lys Thr His Thr Thr Glu Lys Ala Cys
         105                 110                 115

 gaa tgt aag gaa tgt ggg aag ttc ttc tgc cag aag tct gcc ctc ata      857
 Glu Cys Lys Glu Cys Gly Lys Phe Phe Cys Gln Lys Ser Ala Leu Ile
     120                 125                 130

 gta cat cag cat act cac tca aag ggc aaa tcc tat gac tgt gat aaa      905
 Val His Gln His Thr His Ser Lys Gly Lys Ser Tyr Asp Cys Asp Lys
 135                 140                 145                 150

 tgt ggg aaa tct ttc tct aaa aat gaa gac ctc ata aga cat cag aaa      953
 Cys Gly Lys Ser Phe Ser Lys Asn Glu Asp Leu Ile Arg His Gln Lys
                 155                 160                 165

 att cac acg aga gat aaa acc tat gag tgt aaa gaa tgt aag aaa ata     1001
 Ile His Thr Arg Asp Lys Thr Tyr Glu Cys Lys Glu Cys Lys Lys Ile
             170                 175                 180

 ttt tac cac cta tca tct ctc agt aga cat ctg aga acc cat gca gga     1049
 Phe Tyr His Leu Ser Ser Leu Ser Arg His Leu Arg Thr His Ala Gly
         185                 190                 195

 gag aaa ccc tat gaa tgt aat cag tgt gaa aaa tcc ttc tac cag aaa     1097
 Glu Lys Pro Tyr Glu Cys Asn Gln Cys Glu Lys Ser Phe Tyr Gln Lys
     200                 205                 210

 cca cat ctc aca gaa cat cag aaa aca cac aca ggg gag aaa cct ttt     1145
 Pro His Leu Thr Glu His Gln Lys Thr His Thr Gly Glu Lys Pro Phe
 215                 220                 225                 230

 gaa tgt act gaa tgt ggg aag ttc ttc tat gtg aag gca tac ctc atg     1193
 Glu Cys Thr Glu Cys Gly Lys Phe Phe Tyr Val Lys Ala Tyr Leu Met
                 235                 240                 245

 gta cat cag aaa aca cac aca ggg gag aaa ccc tat gag tgt aag gag     1241
 Val His Gln Lys Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu
             250                 255                 260

 tgt ggg aaa gcc ttt tcc cag aag tca cac ctc aca gta cat cag aga     1289
 Cys Gly Lys Ala Phe Ser Gln Lys Ser His Leu Thr Val His Gln Arg
         265                 270                 275

 atg cac aca ggg gag aaa ccc tat aaa tgt aag gaa tgt ggg aaa ttc     1337
 Met His Thr Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys Phe
     280                 285                 290

 ttc tct agg aat tca cac ctc aaa act cat cag aga agt cac aca gga     1385
 Phe Ser Arg Asn Ser His Leu Lys Thr His Gln Arg Ser His Thr Gly
 295                 300                 305                 310

 gag aaa ccc tat gaa tgt aag gaa tgt agg aaa tgc ttc tac cag aag     1433
 Glu Lys Pro Tyr Glu Cys Lys Glu Cys Arg Lys Cys Phe Tyr Gln Lys
                 315                 320                 325

 tca gcc ctc aca gta cat cag cga act cac aca ggg gag aaa ccc ttt     1481
 Ser Ala Leu Thr Val His Gln Arg Thr His Thr Gly Glu Lys Pro Phe
             330                 335                 340

 gaa tgt aat aaa tgt ggg aaa aca ttt tac tat aaa tca gac ctc act     1529
 Glu Cys Asn Lys Cys Gly Lys Thr Phe Tyr Tyr Lys Ser Asp Leu Thr
         345                 350                 355

 aaa cat cag aga aaa cac aca ggg gag aag ccc tat gaa tgc aca gaa     1577
 Lys His Gln Arg Lys His Thr Gly Glu Lys Pro Tyr Glu Cys Thr Glu
     360                 365                 370

 tgt ggc aaa tct ttt gct gtg aat tca gtc ctc aga tta cat caa agg     1625
 Cys Gly Lys Ser Phe Ala Val Asn Ser Val Leu Arg Leu His Gln Arg
 375                 380                 385                 390

 act cac aca gga gag aag ccc tat gca tgc aag gaa tgt ggg aag tcc     1673
 Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Lys Glu Cys Gly Lys Ser
                 395                 400                 405

 ttt tct cag aag tca cat ttt att ata cat cag aga aaa cac aca ggg     1721
 Phe Ser Gln Lys Ser His Phe Ile Ile His Gln Arg Lys His Thr Gly
             410                 415                 420

 gag aag ccc tat gag tgt cag gag tgt ggg gaa acc ttt atc cag aag     1769
 Glu Lys Pro Tyr Glu Cys Gln Glu Cys Gly Glu Thr Phe Ile Gln Lys
         425                 430                 435

 tca caa ctc act gca cat cag aag aca cac aca aag aag agg aat gct     1817
 Ser Gln Leu Thr Ala His Gln Lys Thr His Thr Lys Lys Arg Asn Ala
     440                 445                 450

 gag aag taa gatgagt tgggaaattc tcttgactga attaatcctt caaaacaatc     1873
 Glu Lys 
 455

 agataattca cacaagaggt acaccttatg aatcgcatca atagagggaa attttcagct   1933

 acaatctttg ctctctctgt gtatcagcaa atacatagag agattctgta catttatttg   1993

 ggagaaaatt ttatcata                                                 2011




      <210> 287
      <211> 2309
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(2039)

      <400> 287
 gcgtgctgtg aatttaatat ggctgcgctg ggatctgttc accttcaggc tgagtcgaga     60

 ctgaggatta t atg gtt ttt gag gac gtg gcc ata cat ttc tcc cag gag     110
              Met Val Phe Glu Asp Val Ala Ile His Phe Ser Gln Glu
                1               5                  10

 gag tgg gga att ctt aat gac gtt cag aga cac ctg cac agc gat gtg      158
 Glu Trp Gly Ile Leu Asn Asp Val Gln Arg His Leu His Ser Asp Val
      15                  20                  25

 atg ctg gag aac ttt gca ctt ttg tcc tca gta ggt tgt tgg cat gga      206
 Met Leu Glu Asn Phe Ala Leu Leu Ser Ser Val Gly Cys Trp His Gly
  30                  35                  40                  45

 gcc aag gat gag gag gca cct tcc aag caa tgt gtt tct gta gga gtg      254
 Ala Lys Asp Glu Glu Ala Pro Ser Lys Gln Cys Val Ser Val Gly Val
                  50                  55                  60

 tca cag gtc aca act tta aag cca gct ttg tcc acc cag aag gcc cag      302
 Ser Gln Val Thr Thr Leu Lys Pro Ala Leu Ser Thr Gln Lys Ala Gln
              65                  70                  75

 ccc tgt gag aca tgt agc tca ctt ctg aag gac att cta cac ctg gct      350
 Pro Cys Glu Thr Cys Ser Ser Leu Leu Lys Asp Ile Leu His Leu Ala
          80                  85                  90

 gag cat gac gga aca cac ccc aag cgt aca gcc aag ctt tac ctg cac      398
 Glu His Asp Gly Thr His Pro Lys Arg Thr Ala Lys Leu Tyr Leu His
      95                 100                 105

 caa aag gag cat ctt aga gag aag ctc acc aga agt gat gaa ggg agg      446
 Gln Lys Glu His Leu Arg Glu Lys Leu Thr Arg Ser Asp Glu Gly Arg
 110                 115                 120                 125

 cct tcg ttt gtg aat gac agt gtt cac ctg gca aag agg aac ctc aaa      494
 Pro Ser Phe Val Asn Asp Ser Val His Leu Ala Lys Arg Asn Leu Lys
                 130                 135                 140

 tgc atg cag ggt ggc aag gat ttt act ggt gat tca gat ctt caa caa      542
 Cys Met Gln Gly Gly Lys Asp Phe Thr Gly Asp Ser Asp Leu Gln Gln
             145                 150                 155

 cag gct ctt cac agt ggg tgg aag cca cac agg gac act cat ggt gtg      590
 Gln Ala Leu His Ser Gly Trp Lys Pro His Arg Asp Thr His Gly Val
         160                 165                 170

 gag gcc ttt caa agt gga cag aat aat tac agc tgc acc caa tgt ggg      638
 Glu Ala Phe Gln Ser Gly Gln Asn Asn Tyr Ser Cys Thr Gln Cys Gly
     175                 180                 185

 aaa gac ttt tgc cac caa cat aca ctg ttt gag cac cag aaa atc cac      686
 Lys Asp Phe Cys His Gln His Thr Leu Phe Glu His Gln Lys Ile His
 190                 195                 200                 205

 aca gag gaa agg cct tat gag tgc agt gaa tgt ggc aaa ttg ttt agg      734
 Thr Glu Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Leu Phe Arg
                 210                 215                 220

 tac aac tcc gac ctt att aaa cat cag cga aat cat act gga gaa agg      782
 Tyr Asn Ser Asp Leu Ile Lys His Gln Arg Asn His Thr Gly Glu Arg
             225                 230                 235

 cct tat aag tgt agt gaa tgt gga aaa gcc ttc agc ctc aaa tac aat      830
 Pro Tyr Lys Cys Ser Glu Cys Gly Lys Ala Phe Ser Leu Lys Tyr Asn
         240                 245                 250

 gtt gtt caa cac cag aaa att cac act gga gaa agg cct tat gag tgc      878
 Val Val Gln His Gln Lys Ile His Thr Gly Glu Arg Pro Tyr Glu Cys
     255                 260                 265

 agt gaa tgt ggg aaa gct ttt ctt aga aag tct cac cta ctt cag cac      926
 Ser Glu Cys Gly Lys Ala Phe Leu Arg Lys Ser His Leu Leu Gln His
 270                 275                 280                 285

 cag agg att cac acc agg cca agg cct tat gtg tgt agt gaa tgt ggg      974
 Gln Arg Ile His Thr Arg Pro Arg Pro Tyr Val Cys Ser Glu Cys Gly
                 290                 295                 300

 aag gcc ttc ctt aca cag gct cac ctt gtt ggt cac cag aaa att cat     1022
 Lys Ala Phe Leu Thr Gln Ala His Leu Val Gly His Gln Lys Ile His
             305                 310                 315

 act gga gaa cgg cct tat gga tgc aat gaa tgt ggg aaa tac ttt atg     1070
 Thr Gly Glu Arg Pro Tyr Gly Cys Asn Glu Cys Gly Lys Tyr Phe Met
         320                 325                 330

 tac agt tca gca ctc att aga cat cag aaa gtt cac act gga gaa agg     1118
 Tyr Ser Ser Ala Leu Ile Arg His Gln Lys Val His Thr Gly Glu Arg
     335                 340                 345

 cct ttt tat tgc tgt gaa tgt ggg aaa ttc ttt atg gac agc tgc aca     1166
 Pro Phe Tyr Cys Cys Glu Cys Gly Lys Phe Phe Met Asp Ser Cys Thr
 350                 355                 360                 365

 ctc att att cac cag aga gtt cat act gga gaa aaa cct tat gaa tgc     1214
 Leu Ile Ile His Gln Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys
                 370                 375                 380

 aac gaa tgt ggg aaa ttc ttt aga tac cgt tcc aca ctc att aga cat     1262
 Asn Glu Cys Gly Lys Phe Phe Arg Tyr Arg Ser Thr Leu Ile Arg His
             385                 390                 395

 cag aaa gtt cac act gga gaa aag cct tat gag tgt agt gaa tgt ggg     1310
 Gln Lys Val His Thr Gly Glu Lys Pro Tyr Glu Cys Ser Glu Cys Gly
         400                 405                 410

 aag ttc ttt atg gac act tcc aca ctc att att cat cag aga gtt cat     1358
 Lys Phe Phe Met Asp Thr Ser Thr Leu Ile Ile His Gln Arg Val His
     415                 420                 425

 act gga gaa aag cct tat gaa tgc aac aaa tgt ggg aaa ttc ttt agg     1406
 Thr Gly Glu Lys Pro Tyr Glu Cys Asn Lys Cys Gly Lys Phe Phe Arg
 430                 435                 440                 445

 tat tgc ttc aca ctg aat aga cat cag aga gtt cac tct gga gag agg     1454
 Tyr Cys Phe Thr Leu Asn Arg His Gln Arg Val His Ser Gly Glu Arg
                 450                 455                 460

 cct tat gaa tgc agt gaa tgt ggc aaa ttc ttt gtg gac agc tgt aca     1502
 Pro Tyr Glu Cys Ser Glu Cys Gly Lys Phe Phe Val Asp Ser Cys Thr
             465                 470                 475

 ctg aag agt cat cag aga gtt cac act gga gaa aga cct ttt gaa tgc     1550
 Leu Lys Ser His Gln Arg Val His Thr Gly Glu Arg Pro Phe Glu Cys
         480                 485                 490

 agc att tgt ggg aaa tcc ttt aga tgt cgc tcc aca ctt gat aca cat     1598
 Ser Ile Cys Gly Lys Ser Phe Arg Cys Arg Ser Thr Leu Asp Thr His
     495                 500                 505

 cag aga att cac act ggt gaa agg cct tat gag tgt agt gaa tgt ggg     1646
 Gln Arg Ile His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly
 510                 515                 520                 525

 aaa ttc ttt agg cac aac tca aat cat att aga cat cgg aga aat cac     1694
 Lys Phe Phe Arg His Asn Ser Asn His Ile Arg His Arg Arg Asn His
                 530                 535                 540

 ttt gga gaa agg tct ttt gag tgc act gag tgt ggg aga gtt ttt agc     1742
 Phe Gly Glu Arg Ser Phe Glu Cys Thr Glu Cys Gly Arg Val Phe Ser
             545                 550                 555

 caa aat tcc cac ctc att cgg cac caa aaa gtt cac act agg gaa aga     1790
 Gln Asn Ser His Leu Ile Arg His Gln Lys Val His Thr Arg Glu Arg
         560                 565                 570

 act tac aaa tgc agc aaa tgt ggg aaa ttt ttt atg gac agc tcc aca     1838
 Thr Tyr Lys Cys Ser Lys Cys Gly Lys Phe Phe Met Asp Ser Ser Thr
     575                 580                 585

 ctc att agt cat gag aga gtt cat act gga gaa aag cct tat gag tgc     1886
 Leu Ile Ser His Glu Arg Val His Thr Gly Glu Lys Pro Tyr Glu Cys
 590                 595                 600                 605

 agt gaa tgt ggg aaa gtc ttt aga tac aac tcc agc ctc att aaa cat     1934
 Ser Glu Cys Gly Lys Val Phe Arg Tyr Asn Ser Ser Leu Ile Lys His
                 610                 615                 620

 cgg aga att cac act gga gag aga cct tat cag tgc agt gaa tgt gga     1982
 Arg Arg Ile His Thr Gly Glu Arg Pro Tyr Gln Cys Ser Glu Cys Gly
             625                 630                 635

 aga gtc ttt aac caa aat tct cat ctc att cag cac cag aaa gtt cac     2030
 Arg Val Phe Asn Gln Asn Ser His Leu Ile Gln His Gln Lys Val His
         640                 645                 650

 acc aga taa agaatgt atatataaag cagatgggga aagacttcac acagaaatct     2086
 Thr Arg 
     655

 actctgattt agcactggga cctacgtttt aaaaaaagta ttcttgtaga atacagataa   2146

 cataaaatct aacatcttaa ccatgttaaa gtgtatagtt cagtaccgtt aagtcattca   2206

 cattgtgcaa tgaatatcta gaagtctttt caacttatga aactaagtct atacctttta   2266

 aaaccttatt cctcactcca tccagcctct tgacaagcac cgc                     2309




      <210> 288
      <211> 459
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (8)..(319)

      <400> 288
 aaggatc  atg ggt ttt gtt ttc ttt att ttc ttc ttt tgc aag gat tgc      49
          Met Gly Phe Val Phe Phe Ile Phe Phe Phe Cys Lys Asp Cys
            1               5                  10

 cat act aag gaa ttc ctc att ata ttt tgt gtt gtt ccc att gca gcc       97
 His Thr Lys Glu Phe Leu Ile Ile Phe Cys Val Val Pro Ile Ala Ala
  15                  20                  25                  30

 agt cag aaa tct tcc aac ttg gaa ggg aga acg aag tca gtc atc agg      145
 Ser Gln Lys Ser Ser Asn Leu Glu Gly Arg Thr Lys Ser Val Ile Arg
                  35                  40                  45

 cag act ggg tca tct gct gaa atc act tgt gat ctt gct gaa gga agt      193
 Gln Thr Gly Ser Ser Ala Glu Ile Thr Cys Asp Leu Ala Glu Gly Ser
              50                  55                  60

 acc ggc tac atc cac tgg tac cta cac cag gag ggg aag gcc cca cag      241
 Thr Gly Tyr Ile His Trp Tyr Leu His Gln Glu Gly Lys Ala Pro Gln
          65                  70                  75

 cgt ctt ctg tac tat gac tcc tac acc tcc agc gtt gtg ttg gaa tca      289
 Arg Leu Leu Tyr Tyr Asp Ser Tyr Thr Ser Ser Val Val Leu Glu Ser
      80                  85                  90

 gga atc agc cca ggg aag tat gat act tag a gcagactccg ggacacacca      340
 Gly Ile Ser Pro Gly Lys Tyr Asp Thr 
  95                 100

 acacacatga tcctcagtcc ttttaataaa gcacgttcaa cccttctcag agtgaccttg    400

 agtggttgcc tccatgagtc caacatctgc agtccctcag ctggaggctt gagacgaaa     459




      <210> 289
      <211> 1256
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (610)..(1173)

      <400> 289
 atctccgaag gggacgaaca aaggtgatgt tcccccatcc cagcaccctc cctcgccacc     60

 tcggccgcgt ccagaagcgt ctcattcaga tagaggtacc cagccgggcc ccaggtctca    120

 cctgggtcag cattgtcccg ctgagagctt tcaaacaaca ggtgtacgcg aatcagtatc    180

 aaaaagcctc cagggaactg aaaaaaacag tctgacttcc gggattcgcg ggcatccact    240

 ttcattctca cgtttcctct tcaatttctc gcgagatact gatttgctcg cgctatagaa    300

 ttcttgtcga agaggcttag ctcccgcggg agatttcgtg cgcagttact tccggtagct    360

 ggtaaaggct gatacttccc aggacgcgga ggtaacgggc cagggccaaa gcgactttcg    420

 ctacttggat tggtcggcgt agctttgggc ggccggacct taaaaagtca cacatctgcg    480

 cgcctgtgcg gcccctgctt ctgcggatgc tgaggcacgt aaaaaaattt gaagaaggga    540

 atttcgcggc attcttggcc tggcttcctg gcgtagccag caagttcgga ggtgttaacc    600

 gctgctgtc    atg ttt ctt ttg cta aac tgc atc gtc gct gtg tcc caa     648
              Met Phe Leu Leu Leu Asn Cys Ile Val Ala Val Ser Gln
                1               5                  10

 aac atg ggc atc ggc aag aac ggg gac ctg ccc agg ccg ccg ctc agg      696
 Asn Met Gly Ile Gly Lys Asn Gly Asp Leu Pro Arg Pro Pro Leu Arg
      15                  20                  25

 aat gaa ttc agg tat ttc cag aga atg acc aca act tct tca gta gag      744
 Asn Glu Phe Arg Tyr Phe Gln Arg Met Thr Thr Thr Ser Ser Val Glu
  30                  35                  40                  45

 ggt aaa cag aat ctg gtg att atg ggt agg aag acc tgg ttc tcc att      792
 Gly Lys Gln Asn Leu Val Ile Met Gly Arg Lys Thr Trp Phe Ser Ile
                  50                  55                  60

 cct gag aag aat cga cct tta aag gat aga att aat tta gtt ctc agc      840
 Pro Glu Lys Asn Arg Pro Leu Lys Asp Arg Ile Asn Leu Val Leu Ser
              65                  70                  75

 aga gaa ctc aag gaa cct cca caa gga gct cat ttt ctt gcc aga agt      888
 Arg Glu Leu Lys Glu Pro Pro Gln Gly Ala His Phe Leu Ala Arg Ser
          80                  85                  90

 ttg gat gat gcc tta aaa ctt act gaa cga cca gaa tta gca aat aaa      936
 Leu Asp Asp Ala Leu Lys Leu Thr Glu Arg Pro Glu Leu Ala Asn Lys
      95                 100                 105

 gta gac atg att tgg ata gtt ggt ggc agt tct gtt tat aag gaa gcc      984
 Val Asp Met Ile Trp Ile Val Gly Gly Ser Ser Val Tyr Lys Glu Ala
 110                 115                 120                 125

 atg aat cac cta ggc cat ctt aaa cta ttt gtg aca agg atc atg cag     1032
 Met Asn His Leu Gly His Leu Lys Leu Phe Val Thr Arg Ile Met Gln
                 130                 135                 140

 gac ttt gaa agt gac acg ttt ttt tca gaa att gac ttg gag aaa tat     1080
 Asp Phe Glu Ser Asp Thr Phe Phe Ser Glu Ile Asp Leu Glu Lys Tyr
             145                 150                 155

 aaa ctt ctg cct gaa tac cca ggt gtt ctc tct gat gtc cag gag ggg     1128
 Lys Leu Leu Pro Glu Tyr Pro Gly Val Leu Ser Asp Val Gln Glu Gly
         160                 165                 170

 aaa cac atc aag tac aaa ttt gaa gta tgt gag aag gat gat taa tat     1176
 Lys His Ile Lys Tyr Lys Phe Glu Val Cys Glu Lys Asp Asp 
     175                 180                 185

 gaaggtgttt tctggtttaa gttgttcccc ctccctctga gaaaagatat gcatttttac   1236

 attagaaaag ggactgtatt                                               1256




      <210> 290
      <211> 2658
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(2454)

      <400> 290
 gggtcgacga tttcgtagcg gccgggccca cggccccgag cagcc    atg ctg ggc      54
                                                      Met Leu Gly
                                                        1

 gcg cgg gcc tgg ttg ggc cgc gtc ctt ctg ctg ccc cgc gcc ggt gca      102
 Ala Arg Ala Trp Leu Gly Arg Val Leu Leu Leu Pro Arg Ala Gly Ala
       5                  10                  15

 ggc ctc gcc gcg agc cgc agg tgt cct gga gtc tgg ccc agg acc tgg      150
 Gly Leu Ala Ala Ser Arg Arg Cys Pro Gly Val Trp Pro Arg Thr Trp
  20                  25                  30                  35

 ccc cac agg agt ccc agc agg ggt agc tcc tcc cgg gac aag gac cga      198
 Pro His Arg Ser Pro Ser Arg Gly Ser Ser Ser Arg Asp Lys Asp Arg
                  40                  45                  50

 agt gcg acg gtc agt agt tca gtg ccc atg cct gct gga ggg aaa gga      246
 Ser Ala Thr Val Ser Ser Ser Val Pro Met Pro Ala Gly Gly Lys Gly
              55                  60                  65

 agc cat cct tca tct aca ccc cag agg gtc ccc aac cgc ctg atc cac      294
 Ser His Pro Ser Ser Thr Pro Gln Arg Val Pro Asn Arg Leu Ile His
          70                  75                  80

 gag aag tca cca tac ctc cta caa cat gcc tac aat cct gtg gac tgg      342
 Glu Lys Ser Pro Tyr Leu Leu Gln His Ala Tyr Asn Pro Val Asp Trp
      85                  90                  95

 tac ccc tgg gga cag gaa gcc ttc gac aag gcc agg aag gaa aac aag      390
 Tyr Pro Trp Gly Gln Glu Ala Phe Asp Lys Ala Arg Lys Glu Asn Lys
 100                 105                 110                 115

 ccg att ttc ctc tca gtc ggg tac tcc acc tgc cac tgg tgc cac atg      438
 Pro Ile Phe Leu Ser Val Gly Tyr Ser Thr Cys His Trp Cys His Met
                 120                 125                 130

 atg gaa gag gag tcc ttc cag aat gag gag att ggc cgc ctg ctc agt      486
 Met Glu Glu Glu Ser Phe Gln Asn Glu Glu Ile Gly Arg Leu Leu Ser
             135                 140                 145

 gag gac ttt gtg agt gtg aag gta gac cgt gag gag cgg cct gac gtg      534
 Glu Asp Phe Val Ser Val Lys Val Asp Arg Glu Glu Arg Pro Asp Val
         150                 155                 160

 gac aag gtg tac atg acg ttc gtg cag gcc acc agc agc ggc ggg ggc      582
 Asp Lys Val Tyr Met Thr Phe Val Gln Ala Thr Ser Ser Gly Gly Gly
     165                 170                 175

 tgg ccc atg aat gtg tgg ctg act ccc aac ctc cag ccc ttt gtc ggg      630
 Trp Pro Met Asn Val Trp Leu Thr Pro Asn Leu Gln Pro Phe Val Gly
 180                 185                 190                 195

 ggc acc tat ttc cct cct gag gat ggc ttg acc cga gtc ggc ttc cgc      678
 Gly Thr Tyr Phe Pro Pro Glu Asp Gly Leu Thr Arg Val Gly Phe Arg
                 200                 205                 210

 aca gtg ttg ctg aga ata cga gaa cag tgg aaa cag aac aag aac acc      726
 Thr Val Leu Leu Arg Ile Arg Glu Gln Trp Lys Gln Asn Lys Asn Thr
             215                 220                 225

 ctg cta gaa aat agc cag cgt gtc acc act gcc ctg ctg gcc cga tca      774
 Leu Leu Glu Asn Ser Gln Arg Val Thr Thr Ala Leu Leu Ala Arg Ser
         230                 235                 240

 gag atc agc gtg ggt gac cgc cag ctg ccg ccc tct gcc gcc acc gtg      822
 Glu Ile Ser Val Gly Asp Arg Gln Leu Pro Pro Ser Ala Ala Thr Val
     245                 250                 255

 aac aat cgc tgc ttc cag cag ctg gat gag ggc tat gat gag gaa tac      870
 Asn Asn Arg Cys Phe Gln Gln Leu Asp Glu Gly Tyr Asp Glu Glu Tyr
 260                 265                 270                 275

 ggt ggc ttc gct gag gcc ccc aag ttt ccc acg ccg gtg atc ctg agc      918
 Gly Gly Phe Ala Glu Ala Pro Lys Phe Pro Thr Pro Val Ile Leu Ser
                 280                 285                 290

 ttc ctg ttc tcc tac tgg ctc agc cat cga ctg act cag gat ggc tct      966
 Phe Leu Phe Ser Tyr Trp Leu Ser His Arg Leu Thr Gln Asp Gly Ser
             295                 300                 305

 cgg gcc cag cag atg gcc ttg cat acc ctg aaa atg atg gct aac ggg     1014
 Arg Ala Gln Gln Met Ala Leu His Thr Leu Lys Met Met Ala Asn Gly
         310                 315                 320

 ggc atc cgg gac cat gtg ggg cag ggc ttt cac cgc tac tcc aca gac     1062
 Gly Ile Arg Asp His Val Gly Gln Gly Phe His Arg Tyr Ser Thr Asp
     325                 330                 335

 cgc cag tgg cac gtc cct cac ttt gag aag atg ctc tat gac cag gca     1110
 Arg Gln Trp His Val Pro His Phe Glu Lys Met Leu Tyr Asp Gln Ala
 340                 345                 350                 355

 cag ctc gct gtg gcc tat tcg cag gcc ttc cag ctc tct ggt gat gaa     1158
 Gln Leu Ala Val Ala Tyr Ser Gln Ala Phe Gln Leu Ser Gly Asp Glu
                 360                 365                 370

 ttc tac tct gac gtg gcc aaa ggc atc ctg cag tac gtg gct cgg agc     1206
 Phe Tyr Ser Asp Val Ala Lys Gly Ile Leu Gln Tyr Val Ala Arg Ser
             375                 380                 385

 ctg agc cac cgg tcc gga ggc ttc tat agc gca gag gat gca gac tcg     1254
 Leu Ser His Arg Ser Gly Gly Phe Tyr Ser Ala Glu Asp Ala Asp Ser
         390                 395                 400

 ccc cca gag cgg ggc cag cgg ccc aaa gag ggc gcc tac tat gtg tgg     1302
 Pro Pro Glu Arg Gly Gln Arg Pro Lys Glu Gly Ala Tyr Tyr Val Trp
     405                 410                 415

 acg gtc aaa gag gtt cag cag ctc ctc ccg gag cct gtg ttg ggt gcc     1350
 Thr Val Lys Glu Val Gln Gln Leu Leu Pro Glu Pro Val Leu Gly Ala
 420                 425                 430                 435

 acc gag ccg ctg acc tca ggc cag ctc ctc atg aag cac tac ggc ctc     1398
 Thr Glu Pro Leu Thr Ser Gly Gln Leu Leu Met Lys His Tyr Gly Leu
                 440                 445                 450

 aca gag gct ggt aac atc agc ccc agt cag gac ccc aag ggg gag ctg     1446
 Thr Glu Ala Gly Asn Ile Ser Pro Ser Gln Asp Pro Lys Gly Glu Leu
             455                 460                 465

 cag ggc cag aat gtg ctg acc gtc cgg tac tcg ctg gag ctg act gct     1494
 Gln Gly Gln Asn Val Leu Thr Val Arg Tyr Ser Leu Glu Leu Thr Ala
         470                 475                 480

 gcc cgc ttt ggc ttg gat gtg gag gcc gtg cgg acc ttg ctc aat aca     1542
 Ala Arg Phe Gly Leu Asp Val Glu Ala Val Arg Thr Leu Leu Asn Thr
     485                 490                 495

 ggg ctg gag aag ctc ttc cag gcc cgg aag cat cgg ccc aag ccg cac     1590
 Gly Leu Glu Lys Leu Phe Gln Ala Arg Lys His Arg Pro Lys Pro His
 500                 505                 510                 515

 ctg gac agc aag atg ctg gct gcc tgg aat ggc ttg atg gtg tca ggc     1638
 Leu Asp Ser Lys Met Leu Ala Ala Trp Asn Gly Leu Met Val Ser Gly
                 520                 525                 530

 tat gct gtg act ggg gct gtc ctg ggc caa gac agg ctg atc aac tat     1686
 Tyr Ala Val Thr Gly Ala Val Leu Gly Gln Asp Arg Leu Ile Asn Tyr
             535                 540                 545

 gcc acc aat ggt gcc aag ttc ctg aag cgg cac atg ttt gat gtg gcc     1734
 Ala Thr Asn Gly Ala Lys Phe Leu Lys Arg His Met Phe Asp Val Ala
         550                 555                 560

 agt ggc cgc ctg atg cgg acc tgc tac acc ggc cct ggg ggg act gtg     1782
 Ser Gly Arg Leu Met Arg Thr Cys Tyr Thr Gly Pro Gly Gly Thr Val
     565                 570                 575

 gag cac agc aac cca ccc tgc tgg ggc ttc ctg gag gac tac gcc ttc     1830
 Glu His Ser Asn Pro Pro Cys Trp Gly Phe Leu Glu Asp Tyr Ala Phe
 580                 585                 590                 595

 gtg gtg cgg ggc ctg ctg gac ctg tat gag gcc tca cag gag agt gcg     1878
 Val Val Arg Gly Leu Leu Asp Leu Tyr Glu Ala Ser Gln Glu Ser Ala
                 600                 605                 610

 tgg ctc gag tgg gct ctg cgg ctg cag gac aca cag gac agg ctc ttt     1926
 Trp Leu Glu Trp Ala Leu Arg Leu Gln Asp Thr Gln Asp Arg Leu Phe
             615                 620                 625

 tgg gac tcc cag ggt ggc ggc tac ttc tgc agt gag gct gag ctg ggg     1974
 Trp Asp Ser Gln Gly Gly Gly Tyr Phe Cys Ser Glu Ala Glu Leu Gly
         630                 635                 640

 gct ggc ctg ccc ctg cgt ctg aag gac gac cag gat gga gca gag ccc     2022
 Ala Gly Leu Pro Leu Arg Leu Lys Asp Asp Gln Asp Gly Ala Glu Pro
     645                 650                 655

 agc gcc aat tcc gtg tca gcc cac aac ctg ctc cgg ctg cat ggc ttc     2070
 Ser Ala Asn Ser Val Ser Ala His Asn Leu Leu Arg Leu His Gly Phe
 660                 665                 670                 675

 acg ggc cac aag gac tgg atg gac aag tgt gtg tgc cta ttg acc gcc     2118
 Thr Gly His Lys Asp Trp Met Asp Lys Cys Val Cys Leu Leu Thr Ala
                 680                 685                 690

 ttt tcc gag cgc atg cgt cgt gtc ccg gtg gcg ttg ccc gag atg gtc     2166
 Phe Ser Glu Arg Met Arg Arg Val Pro Val Ala Leu Pro Glu Met Val
             695                 700                 705

 cgc gcc ctc tca gcc cag cag cag acc ctc aag cag atc gtg atc tgt     2214
 Arg Ala Leu Ser Ala Gln Gln Gln Thr Leu Lys Gln Ile Val Ile Cys
         710                 715                 720

 gga gac cgt cag gcc aag gac acc aag gcc ctg gtg cag tgc gtc cac     2262
 Gly Asp Arg Gln Ala Lys Asp Thr Lys Ala Leu Val Gln Cys Val His
     725                 730                 735

 tct gtc tac att cct aac aag gtg ctg att ctg gct gat ggg gac ccc     2310
 Ser Val Tyr Ile Pro Asn Lys Val Leu Ile Leu Ala Asp Gly Asp Pro
 740                 745                 750                 755

 tcg agc ttc ctg tcc cgc cag ctg cct ttc ctg agt acc ctc cga cgg     2358
 Ser Ser Phe Leu Ser Arg Gln Leu Pro Phe Leu Ser Thr Leu Arg Arg
                 760                 765                 770

 ttg gaa gac cag gcc act gca tat gtg tgt gag aat caa gcc tgc tca     2406
 Leu Glu Asp Gln Ala Thr Ala Tyr Val Cys Glu Asn Gln Ala Cys Ser
             775                 780                 785

 gtg ccc atc act gat ccc tgc gaa tta cga aaa cta cta cat cca tga     2454
 Val Pro Ile Thr Asp Pro Cys Glu Leu Arg Lys Leu Leu His Pro 
         790                 795                 800

 ctgccccaac ccccttgggg tggggcagaa ggtgaagcat cccaactgac tagagactca   2514

 ggccctgcag ggccctatag aacctgtggc catccctgag caccctgcca ccaggtgacc   2574

 tcggccatac tcactgcccc ccttgggcac ccactcaccc tagaataaac ttaacagtgt   2634

 cccgtggtaa aaaaaaaaaa aaaa                                          2658




      <210> 291
      <211> 974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(782)

      <400> 291
 aaggatcctt aattaaatta atcccccccc cccagttccc gcgggcggtg gggacggcgc     60

 cctcaccgcg agtcacttgt cagcccttgt ctgaggcgga ggcagccccg cgccgcgccg    120

 gacccgagca tatttcattt tctgtcattg gactttgagc cattagaacc   atg agc     176
                                                          Met Ser
                                                            1

 aac tac agt gtg tca ctg gtt ggc cca gct cct tgg ggt ttc cgg ctg      224
 Asn Tyr Ser Val Ser Leu Val Gly Pro Ala Pro Trp Gly Phe Arg Leu
           5                  10                  15

 cag ggc ggt aag gat ttc aac atg cct ctg aca atc tct agt cta aaa      272
 Gln Gly Gly Lys Asp Phe Asn Met Pro Leu Thr Ile Ser Ser Leu Lys
      20                  25                  30

 gat ggc ggc aag gca gcc cag gca aat gta aga ata ggc gat gtg gtt      320
 Asp Gly Gly Lys Ala Ala Gln Ala Asn Val Arg Ile Gly Asp Val Val
  35                  40                  45                  50

 ctc agc att gat gga ata aat gca caa gga atg act cat ctt gaa gcc      368
 Leu Ser Ile Asp Gly Ile Asn Ala Gln Gly Met Thr His Leu Glu Ala
                  55                  60                  65

 cag aat aag att aag ggt tgt aca ggc tct ttg aat atg act ctg caa      416
 Gln Asn Lys Ile Lys Gly Cys Thr Gly Ser Leu Asn Met Thr Leu Gln
              70                  75                  80

 aga gca tct gct gca ccc aag cct gag ccg gtt cct gtt caa aag ccc      464
 Arg Ala Ser Ala Ala Pro Lys Pro Glu Pro Val Pro Val Gln Lys Pro
          85                  90                  95

 aca gtc acc agc gtg tgt tcc gag act tct cag gag cta gca gag gga      512
 Thr Val Thr Ser Val Cys Ser Glu Thr Ser Gln Glu Leu Ala Glu Gly
     100                 105                 110

 cag aga aga gga tcc cag ggt gac agt aaa cag caa aat ggg aaa atc      560
 Gln Arg Arg Gly Ser Gln Gly Asp Ser Lys Gln Gln Asn Gly Lys Ile
 115                 120                 125                 130

 cca cct aaa cgc cca cca aga aaa cac att gtg gag cgc tat aca gag      608
 Pro Pro Lys Arg Pro Pro Arg Lys His Ile Val Glu Arg Tyr Thr Glu
                 135                 140                 145

 ttt tat cat gta ccc act cac agt gat gcc agc aag aag aga ctg att      656
 Phe Tyr His Val Pro Thr His Ser Asp Ala Ser Lys Lys Arg Leu Ile
             150                 155                 160

 gag gat act gaa gac tgg cgt cca agg act gga aca act cag tct cgc      704
 Glu Asp Thr Glu Asp Trp Arg Pro Arg Thr Gly Thr Thr Gln Ser Arg
         165                 170                 175

 tct ttc cga atc ctt gcc cag atc act ggg act gaa cat ttg aaa gaa      752
 Ser Phe Arg Ile Leu Ala Gln Ile Thr Gly Thr Glu His Leu Lys Glu
     180                 185                 190

 tct gaa gcc gat aat aca aag aag gca tag t ttgacagtgc tctggaagac      803
 Ser Glu Ala Asp Asn Thr Lys Lys Ala 
 195                 200

 ctacctaaga gtggacctca ccctcctgca acttctcagg tgttaactat tggtagccaa    863

 gtgggcacac tttttaaagg agccacttac tatttttatt ttaaccgctt cccagggaaa    923

 tggggaaaaa ttctttcgaa gttttcgaaa cttttctacc ttcttttttt g             974




      <210> 292
      <211> 1803
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (7)..(1776)

      <400> 292
 acggcg   atg acg cca ccg aca gga cga cga ctg tgt ctc gcg ccc tgc      48
          Met Thr Pro Pro Thr Gly Arg Arg Leu Cys Leu Ala Pro Cys
            1               5                  10

 ggc ggc att tat gtg ccg gac tct agg ggt aca ttt tct gag acg gga       96
 Gly Gly Ile Tyr Val Pro Asp Ser Arg Gly Thr Phe Ser Glu Thr Gly
  15                  20                  25                  30

 aaa cct gca ttg ata aaa gtg gga cag agc ggg gtc aga ccg ctc cta      144
 Lys Pro Ala Leu Ile Lys Val Gly Gln Ser Gly Val Arg Pro Leu Leu
                  35                  40                  45

 act gtc ccc ctg acc ccg cga tgg gtt aga ctt cgt gct cgc ctg gga      192
 Thr Val Pro Leu Thr Pro Arg Trp Val Arg Leu Arg Ala Arg Leu Gly
              50                  55                  60

 gga gaa gct gcg acc ccc gcg gcg gcg gga gag agg cga ctc cgg cag      240
 Gly Glu Ala Ala Thr Pro Ala Ala Ala Gly Glu Arg Arg Leu Arg Gln
          65                  70                  75

 cgg cgc tgg cgc gag aat ttt cag cgg aac ctg gag gag ggc ctc ttt      288
 Arg Arg Trp Arg Glu Asn Phe Gln Arg Asn Leu Glu Glu Gly Leu Phe
      80                  85                  90

 gaa ctg cct ggg tac cag gta ccc ggt tca gat ctc aac tct tgc caa      336
 Glu Leu Pro Gly Tyr Gln Val Pro Gly Ser Asp Leu Asn Ser Cys Gln
  95                 100                 105                 110

 ttg ctg tac cca tac tgg gct tgc tgg gga tac tgg cac aag tac cag      384
 Leu Leu Tyr Pro Tyr Trp Ala Cys Trp Gly Tyr Trp His Lys Tyr Gln
                 115                 120                 125

 ccc ctg gac cag cct ttg gac aaa ctg agc tgc ctc ttt gac cac cca      432
 Pro Leu Asp Gln Pro Leu Asp Lys Leu Ser Cys Leu Phe Asp His Pro
             130                 135                 140

 gga acc gtg ttc ttc agc atc ttc atg tcc ttc tgg ggc cat ggc ctt      480
 Gly Thr Val Phe Phe Ser Ile Phe Met Ser Phe Trp Gly His Gly Leu
         145                 150                 155

 cct gga gca ctg gaa gca ggg agt gcc acc ttg gcc cac cac tgg gac      528
 Pro Gly Ala Leu Glu Ala Gly Ser Ala Thr Leu Ala His His Trp Asp
     160                 165                 170

 tgc agt gac ttc cag gac cag gag gca atg ccc agt tca gcc ccc cac      576
 Cys Ser Asp Phe Gln Asp Gln Glu Ala Met Pro Ser Ser Ala Pro His
 175                 180                 185                 190

 cac tgg gac tgc agc gac ttc cag gac cag gag gtg atg ccc agt tca      624
 His Trp Asp Cys Ser Asp Phe Gln Asp Gln Glu Val Met Pro Ser Ser
                 195                 200                 205

 gcc ctc cac cac tgg gac tgc agc gac ttc cag gac cag gag gag tgc      672
 Ala Leu His His Trp Asp Cys Ser Asp Phe Gln Asp Gln Glu Glu Cys
             210                 215                 220

 cca cat cta cag ttt gct gcc ctg gcc ctg cag atg acc cag aac cca      720
 Pro His Leu Gln Phe Ala Ala Leu Ala Leu Gln Met Thr Gln Asn Pro
         225                 230                 235

 gtg aca ggc ttg aag gag ccc tac ttc caa ccg cac agc tgc ctt tcc      768
 Val Thr Gly Leu Lys Glu Pro Tyr Phe Gln Pro His Ser Cys Leu Ser
     240                 245                 250

 cac cta ctc acc agc tct gca gcc atc ctc act gtg ctc tgt gtg gtg      816
 His Leu Leu Thr Ser Ser Ala Ala Ile Leu Thr Val Leu Cys Val Val
 255                 260                 265                 270

 atg att ttc ctg gta tct gtc ata att tac cat ggc atc atc agc att      864
 Met Ile Phe Leu Val Ser Val Ile Ile Tyr His Gly Ile Ile Ser Ile
                 275                 280                 285

 gca atg ttc cac act ggc aac tct gtg ctc atg acc caa gcg aat gtc      912
 Ala Met Phe His Thr Gly Asn Ser Val Leu Met Thr Gln Ala Asn Val
             290                 295                 300

 ctt tgg ggc aat gga ggc ccc aaa gcc ctg agt aag gtg ctc tgt gtc      960
 Leu Trp Gly Asn Gly Gly Pro Lys Ala Leu Ser Lys Val Leu Cys Val
         305                 310                 315

 tgc caa caa cag tgc ggt cct ggt ggc tgc cac att cag gtc acc cag     1008
 Cys Gln Gln Gln Cys Gly Pro Gly Gly Cys His Ile Gln Val Thr Gln
     320                 325                 330

 cag ctc atc atc atc atg gtg ggc aaa cag ctg ctc aac cac atg gaa     1056
 Gln Leu Ile Ile Ile Met Val Gly Lys Gln Leu Leu Asn His Met Glu
 335                 340                 345                 350

 gaa ttt gtt ggg ctg gga ggt ggc ccc ggg cct gac act ccc tgc ctg     1104
 Glu Phe Val Gly Leu Gly Gly Gly Pro Gly Pro Asp Thr Pro Cys Leu
                 355                 360                 365

 cca gag ctg cag ttt ggg ttc atc acc atc ttt gtg gga gcc ttc ctg     1152
 Pro Glu Leu Gln Phe Gly Phe Ile Thr Ile Phe Val Gly Ala Phe Leu
             370                 375                 380

 ctg gca ccc ctg ttc act ctg ctc aac aac cgg gta gag att gga ctg     1200
 Leu Ala Pro Leu Phe Thr Leu Leu Asn Asn Arg Val Glu Ile Gly Leu
         385                 390                 395

 gac gcc cac aag ttc ctg tgc aag tac cag cga cca atg gct ggg cgc     1248
 Asp Ala His Lys Phe Leu Cys Lys Tyr Gln Arg Pro Met Ala Gly Arg
     400                 405                 410

 ggc tgg aca tct gga tct gac tgc tcc tgc tgg agg cca tgt gag ctg     1296
 Gly Trp Thr Ser Gly Ser Asp Cys Ser Cys Trp Arg Pro Cys Glu Leu
 415                 420                 425                 430

 att ctg ccc cgg aca aat gcg cgg agc cgg cta ggg tac tgg ctg aac     1344
 Ile Leu Pro Arg Thr Asn Ala Arg Ser Arg Leu Gly Tyr Trp Leu Asn
                 435                 440                 445

 ggg cag ggc cag att cta ggg aga agg agg gga gga aat gcg ggg ttc     1392
 Gly Gln Gly Gln Ile Leu Gly Arg Arg Arg Gly Gly Asn Ala Gly Phe
             450                 455                 460

 gga gtc gag atc cga gag cct ctc cag acc ccg caa ccc aga tac aag     1440
 Gly Val Glu Ile Arg Glu Pro Leu Gln Thr Pro Gln Pro Arg Tyr Lys
         465                 470                 475

 gcc tct cgc gac gtg ggg gtg aac ctc gcc ctc ttc tac tgg aag ctg     1488
 Ala Ser Arg Asp Val Gly Val Asn Leu Ala Leu Phe Tyr Trp Lys Leu
     480                 485                 490

 ctg gct gtg cat gtg cat ctg ggt ttc att atc gcc ttc gag aat gta     1536
 Leu Ala Val His Val His Leu Gly Phe Ile Ile Ala Phe Glu Asn Val
 495                 500                 505                 510

 gtg ttc ttc ttc ctg tgc ccc aac gac cgg ctc gtg ccc gat gtg cca     1584
 Val Phe Phe Phe Leu Cys Pro Asn Asp Arg Leu Val Pro Asp Val Pro
                 515                 520                 525

 gcc ctg gct acc aag ata act gcg cga gcg cta cct ggc caa gca ggc     1632
 Ala Leu Ala Thr Lys Ile Thr Ala Arg Ala Leu Pro Gly Gln Ala Gly
             530                 535                 540

 ggt ggc aga caa ccg gga gac gct gtt tca gtc agc aag gca ggc gga     1680
 Gly Gly Arg Gln Pro Gly Asp Ala Val Ser Val Ser Lys Ala Gly Gly
         545                 550                 555

 ccc cgg ccc cac ccg cag cat aat gac cat aat gac cac gcc cct tgg     1728
 Pro Arg Pro His Pro Gln His Asn Asp His Asn Asp His Ala Pro Trp
     560                 565                 570

 cct gcc ctc aag ctt cag ctc agc cct ctc aag ttc agc act ctc tag     1776
 Pro Ala Leu Lys Leu Gln Leu Ser Pro Leu Lys Phe Ser Thr Leu 
 575                 580                 585

 ccccgcgtac tctgcgttgt taccact                                       1803




      <210> 293
      <211> 3943
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (575)..(3943)

      <400> 293
 atggttcatg gagctgaaat gaatgcattc aatgaacatt gtcgaggact aaccctgcca     60

 gagccccttc cagggcctcc catccgccta catctctctc cggtggggat cccaggttca    120

 gccagaccct caaggctgga gcgtgtggcc cgggagatcg tggagacaga acgggcctat    180

 gtcagggacc tccgcagcat cgtggaggac tacctgggcc ctctgctgga cggcggggtc    240

 ctggggctga gcgtggagca ggtgggcacg ctgtttgcca acattgagga catctacgag    300

 ttcagcagcg agctcctgga ggacttggag aacagcagca gcgccggggg tattgccgag    360

 tgcttcgtgc agaggctccc tggccctgct ccgggagctg tcgttgtctc cgccagcagc    420

 cctgtggctg caggagcgcc aggcccagct tcgccactcg ctgcccctgc agagcttcct    480

 gctgaaacct gtccagcgca ttctcaagta ccatctgctg ctgcaggaac tagggaagca    540

 ctgggcggag ggcccaggca ctgggggtcg cgag    atg gtg gag gaa gct att     592
                                          Met Val Glu Glu Ala Ile
                                            1               5

 gtg tcc atg aca gcg gtt gcc tgg tac atc aac gac atg aag cgc aag      640
 Val Ser Met Thr Ala Val Ala Trp Tyr Ile Asn Asp Met Lys Arg Lys
              10                  15                  20

 cag gag cat gca gcg cgc ctc cag gaa gtg cag cgg cgg ctg ggt ggc      688
 Gln Glu His Ala Ala Arg Leu Gln Glu Val Gln Arg Arg Leu Gly Gly
          25                  30                  35

 tgg acc gga cca gag ctc agt gct ttt ggg gaa ctg gtg ttg gag ggc      736
 Trp Thr Gly Pro Glu Leu Ser Ala Phe Gly Glu Leu Val Leu Glu Gly
      40                  45                  50

 gcg ttc cga gga ggc gga ggg ggt ggc ccc cgg cta cga ggg ggt gag      784
 Ala Phe Arg Gly Gly Gly Gly Gly Gly Pro Arg Leu Arg Gly Gly Glu
  55                  60                  65                  70

 cgg ctg ctc ttc ctg ttc tct cgg atg ctg ctg gtg gcc aag cgc agg      832
 Arg Leu Leu Phe Leu Phe Ser Arg Met Leu Leu Val Ala Lys Arg Arg
                  75                  80                  85

 ggg ctg gag tac acc tac aaa ggc cac atc ttc tgc tgc aac ctg agc      880
 Gly Leu Glu Tyr Thr Tyr Lys Gly His Ile Phe Cys Cys Asn Leu Ser
              90                  95                 100

 gtg agc gag agt ccc cga gac cct cta ggg ttc aag gtg tct gat ctg      928
 Val Ser Glu Ser Pro Arg Asp Pro Leu Gly Phe Lys Val Ser Asp Leu
         105                 110                 115

 acc att ccc aag cac aga cac ctg ctc cag gcc aag aac caa gaa gag      976
 Thr Ile Pro Lys His Arg His Leu Leu Gln Ala Lys Asn Gln Glu Glu
     120                 125                 130

 aag agg ctg tgg att cac tgt ctc cag cgc ctc ttc ttt gag aac cac     1024
 Lys Arg Leu Trp Ile His Cys Leu Gln Arg Leu Phe Phe Glu Asn His
 135                 140                 145                 150

 cct gcc tcc atc cct gcc aag gca aag caa gtt ctc ctt gaa aac agc     1072
 Pro Ala Ser Ile Pro Ala Lys Ala Lys Gln Val Leu Leu Glu Asn Ser
                 155                 160                 165

 ctg cat tgt gcc ccc aaa agt aag cct gtc cta gag ccc ctg aca ccc     1120
 Leu His Cys Ala Pro Lys Ser Lys Pro Val Leu Glu Pro Leu Thr Pro
             170                 175                 180

 cca ctt ggg tct cct cga cct cga gat gct aga agt ttt acc cct ggg     1168
 Pro Leu Gly Ser Pro Arg Pro Arg Asp Ala Arg Ser Phe Thr Pro Gly
         185                 190                 195

 cga agg aac aca gct cca tct cct ggg ccc tct gtg att cgc cga ggc     1216
 Arg Arg Asn Thr Ala Pro Ser Pro Gly Pro Ser Val Ile Arg Arg Gly
     200                 205                 210

 cgc agg cag tct gag ccg gtg aag gac cct tat gtc atg ttc cca cag     1264
 Arg Arg Gln Ser Glu Pro Val Lys Asp Pro Tyr Val Met Phe Pro Gln
 215                 220                 225                 230

 aac gct aag cct gga ttc aag cac gct ggc agc gaa ggg gaa ctc tac     1312
 Asn Ala Lys Pro Gly Phe Lys His Ala Gly Ser Glu Gly Glu Leu Tyr
                 235                 240                 245

 cct cca gaa tct cag cca cca gtt tca ggc tct gca ccc cct gag gac     1360
 Pro Pro Glu Ser Gln Pro Pro Val Ser Gly Ser Ala Pro Pro Glu Asp
             250                 255                 260

 ctg gag gat gct gga ccc cca aca ctg gac ccc tct ggg acc tca atc     1408
 Leu Glu Asp Ala Gly Pro Pro Thr Leu Asp Pro Ser Gly Thr Ser Ile
         265                 270                 275

 act gaa gaa atc ctg gaa ctg ctg aat cag cga ggc ctt cga gat cca     1456
 Thr Glu Glu Ile Leu Glu Leu Leu Asn Gln Arg Gly Leu Arg Asp Pro
     280                 285                 290

 ggg ccg tcc acc cat gac att ccc aag ttc ccc gga gac tcc cag gtg     1504
 Gly Pro Ser Thr His Asp Ile Pro Lys Phe Pro Gly Asp Ser Gln Val
 295                 300                 305                 310

 cct ggc gac agc gaa acc ctc aca ttc caa gcc ctg ccc agc cgg gac     1552
 Pro Gly Asp Ser Glu Thr Leu Thr Phe Gln Ala Leu Pro Ser Arg Asp
                 315                 320                 325

 tct tca gaa gag gag gag gag gaa gag gaa ggg ctg gag atg gat gaa     1600
 Ser Ser Glu Glu Glu Glu Glu Glu Glu Glu Gly Leu Glu Met Asp Glu
             330                 335                 340

 cgg ggg cct tcc cca ctc cac gtc ctg gaa ggg ctc gaa agt tcc att     1648
 Arg Gly Pro Ser Pro Leu His Val Leu Glu Gly Leu Glu Ser Ser Ile
         345                 350                 355

 gca gct gaa atg ccc agc att ccc tgc ctt acc aaa att cct gac gtg     1696
 Ala Ala Glu Met Pro Ser Ile Pro Cys Leu Thr Lys Ile Pro Asp Val
     360                 365                 370

 ccc aac ctt cct gaa att ccc agc cgc tgt gaa att ccc gaa ggt tct     1744
 Pro Asn Leu Pro Glu Ile Pro Ser Arg Cys Glu Ile Pro Glu Gly Ser
 375                 380                 385                 390

 cgc ctt cct agt ctc tct gac att tcc gat gtt ttt gag atg ccc tgc     1792
 Arg Leu Pro Ser Leu Ser Asp Ile Ser Asp Val Phe Glu Met Pro Cys
                 395                 400                 405

 ctt cca gcc ata cct agt gtc ccc aac acc ccc agt ctg tct agc act     1840
 Leu Pro Ala Ile Pro Ser Val Pro Asn Thr Pro Ser Leu Ser Ser Thr
             410                 415                 420

 ccc acc ctc tcc tgt gac tcc tgg ctc caa ggg cct ctg cag gaa cca     1888
 Pro Thr Leu Ser Cys Asp Ser Trp Leu Gln Gly Pro Leu Gln Glu Pro
         425                 430                 435

 gct gag gct cca gcc acc agg aga gaa ctg ttt tct ggg agc aat cct     1936
 Ala Glu Ala Pro Ala Thr Arg Arg Glu Leu Phe Ser Gly Ser Asn Pro
     440                 445                 450

 ggg aaa ctg gga gag ccg cct tca gga ggc aag gca ggg cca gag gag     1984
 Gly Lys Leu Gly Glu Pro Pro Ser Gly Gly Lys Ala Gly Pro Glu Glu
 455                 460                 465                 470

 gat gaa gaa ggg gta tca ttc aca gac ttc cag ccc cag gat gtc acc     2032
 Asp Glu Glu Gly Val Ser Phe Thr Asp Phe Gln Pro Gln Asp Val Thr
                 475                 480                 485

 caa cat cag gga ttc cca gat gag ctg gca ttc cgc tct tgc tca gaa     2080
 Gln His Gln Gly Phe Pro Asp Glu Leu Ala Phe Arg Ser Cys Ser Glu
             490                 495                 500

 atc cgg agc gcc tgg cag gca ttg gaa cag gga cag ctg gcc cgg cca     2128
 Ile Arg Ser Ala Trp Gln Ala Leu Glu Gln Gly Gln Leu Ala Arg Pro
         505                 510                 515

 ggc ttc cca gag cca ctg ctg atc ctg gag gat tcg gat ctg ggt gga     2176
 Gly Phe Pro Glu Pro Leu Leu Ile Leu Glu Asp Ser Asp Leu Gly Gly
     520                 525                 530

 gac agc ggg agc ggg aag gca gga gcc ccg agt tca gaa agg acg gcg     2224
 Asp Ser Gly Ser Gly Lys Ala Gly Ala Pro Ser Ser Glu Arg Thr Ala
 535                 540                 545                 550

 tcc cga gtg cga gag ctg gcc cgg ctt tac agc gag cgg atc cag cag     2272
 Ser Arg Val Arg Glu Leu Ala Arg Leu Tyr Ser Glu Arg Ile Gln Gln
                 555                 560                 565

 atg cag cgg gcg gag act cgg gca tca gcc aat gcc ccg cgc cgc cgg     2320
 Met Gln Arg Ala Glu Thr Arg Ala Ser Ala Asn Ala Pro Arg Arg Arg
             570                 575                 580

 cct cgg gtt ctg gcc caa ccc cag cca tcc ccc tgt ctg ccc cag gag     2368
 Pro Arg Val Leu Ala Gln Pro Gln Pro Ser Pro Cys Leu Pro Gln Glu
         585                 590                 595

 cag gca gag cca ggg ctc ctg cct gcc ttt gga cac gtg ctg gta tgt     2416
 Gln Ala Glu Pro Gly Leu Leu Pro Ala Phe Gly His Val Leu Val Cys
     600                 605                 610

 gag ctg gcc ttc cca ctg aca tgt gcc cag gag tct gtc ccc ctg ggt     2464
 Glu Leu Ala Phe Pro Leu Thr Cys Ala Gln Glu Ser Val Pro Leu Gly
 615                 620                 625                 630

 cct gct gtc tgg gtt caa gct gcc ata cct ttg tca aag cag gga ggc     2512
 Pro Ala Val Trp Val Gln Ala Ala Ile Pro Leu Ser Lys Gln Gly Gly
                 635                 640                 645

 agc ccg gat ggc cag ggt cta cat gtt tcc aat ttg cct aag caa gac     2560
 Ser Pro Asp Gly Gln Gly Leu His Val Ser Asn Leu Pro Lys Gln Asp
             650                 655                 660

 ctt ccg ggc atc cac gtt tca gct gct acc ctt ttg cct gag caa gga     2608
 Leu Pro Gly Ile His Val Ser Ala Ala Thr Leu Leu Pro Glu Gln Gly
         665                 670                 675

 ggt tcc cgg cat gtc cag gct cca gcc gcc aca cct ttg ccc aag caa     2656
 Gly Ser Arg His Val Gln Ala Pro Ala Ala Thr Pro Leu Pro Lys Gln
     680                 685                 690

 gaa ggc ccc ctg cac ctc cag gtg ccg gct ctt aca act ttc tct gat     2704
 Glu Gly Pro Leu His Leu Gln Val Pro Ala Leu Thr Thr Phe Ser Asp
 695                 700                 705                 710

 caa ggc cac cca gaa atc caa gtt cca gcc acc act cct ttg cct gag     2752
 Gln Gly His Pro Glu Ile Gln Val Pro Ala Thr Thr Pro Leu Pro Glu
                 715                 720                 725

 cat aaa agt cac atg gtt ata cca gct cca tcc acc gcc ttt tgt cct     2800
 His Lys Ser His Met Val Ile Pro Ala Pro Ser Thr Ala Phe Cys Pro
             730                 735                 740

 gag cag gga cac tgt gcg gac atc cac gtt ccc acc act cca gct ttg     2848
 Glu Gln Gly His Cys Ala Asp Ile His Val Pro Thr Thr Pro Ala Leu
         745                 750                 755

 ccc aag gag att tgt tct gat ttc aca gtt tca gtc acc acc cct gtg     2896
 Pro Lys Glu Ile Cys Ser Asp Phe Thr Val Ser Val Thr Thr Pro Val
     760                 765                 770

 ccc aag caa gaa ggt cac cta gac agc gag agc cca acc aat atc cca     2944
 Pro Lys Gln Glu Gly His Leu Asp Ser Glu Ser Pro Thr Asn Ile Pro
 775                 780                 785                 790

 ctg aca aag caa gga ggt tcc agg gat gtt cag ggc cca gac cct gtc     2992
 Leu Thr Lys Gln Gly Gly Ser Arg Asp Val Gln Gly Pro Asp Pro Val
                 795                 800                 805

 tgc agt caa ccc atc cag cct ttg tct tgg cat gga agc agc ctg gat     3040
 Cys Ser Gln Pro Ile Gln Pro Leu Ser Trp His Gly Ser Ser Leu Asp
             810                 815                 820

 ccc cag ggc cca ggc gac acc cta cca ccc ttg cca tgt cac ctc cca     3088
 Pro Gln Gly Pro Gly Asp Thr Leu Pro Pro Leu Pro Cys His Leu Pro
         825                 830                 835

 gac ctt cag att cca ggt acc tca cct ttg cct gca cat gga agc cac     3136
 Asp Leu Gln Ile Pro Gly Thr Ser Pro Leu Pro Ala His Gly Ser His
     840                 845                 850

 ctg gac cat cgg atc cca gcc aac gcc cca ctg tct ttg tcc cag gag     3184
 Leu Asp His Arg Ile Pro Ala Asn Ala Pro Leu Ser Leu Ser Gln Glu
 855                 860                 865                 870

 ctc cca gac act cag gtt cca gct acc aca cct ttg ccc ctg cca caa     3232
 Leu Pro Asp Thr Gln Val Pro Ala Thr Thr Pro Leu Pro Leu Pro Gln
                 875                 880                 885

 gtc ctc aca gac atc tgg gtc caa gcc ctc cca act tca ccc aag cag     3280
 Val Leu Thr Asp Ile Trp Val Gln Ala Leu Pro Thr Ser Pro Lys Gln
             890                 895                 900

 gga agc ctc cca gac atc cag ggt cca gcg gct gca cct cca ctt ccg     3328
 Gly Ser Leu Pro Asp Ile Gln Gly Pro Ala Ala Ala Pro Pro Leu Pro
         905                 910                 915

 gag cca agc ctt aca gat aca cag gtc caa aaa ctc aca cct tcg ttg     3376
 Glu Pro Ser Leu Thr Asp Thr Gln Val Gln Lys Leu Thr Pro Ser Leu
     920                 925                 930

 gag cag aag agc ctc ata gat gcc cat gtt cca gct gcc aca cct tta     3424
 Glu Gln Lys Ser Leu Ile Asp Ala His Val Pro Ala Ala Thr Pro Leu
 935                 940                 945                 950

 cct gag aga gga ggc tct cta gac att cag ggc ctc tca ccc acc cca     3472
 Pro Glu Arg Gly Gly Ser Leu Asp Ile Gln Gly Leu Ser Pro Thr Pro
                 955                 960                 965

 gtt cag acc acc atg gtt ttg tcc aaa cca gga ggc tcc tta gcc tct     3520
 Val Gln Thr Thr Met Val Leu Ser Lys Pro Gly Gly Ser Leu Ala Ser
             970                 975                 980

 cac gtt gcc agg ttg gag tct tca gac ttg acg cca cct cat agt ccc     3568
 His Val Ala Arg Leu Glu Ser Ser Asp Leu Thr Pro Pro His Ser Pro
         985                 990                 995

 cca cct tcc agc cgt cag ctc ctg ggc ccc aat gca gct gcc ctc tcc     3616
 Pro Pro Ser Ser Arg Gln Leu Leu Gly Pro Asn Ala Ala Ala Leu Ser
    1000                1005                1010

 aga tac ctg gca gcc tca tat atc agc caa agc ctg gct cgg cgg cag     3664
 Arg Tyr Leu Ala Ala Ser Tyr Ile Ser Gln Ser Leu Ala Arg Arg Gln
1015                1020                1025                1030

 ggg cct ggg gga ggg gcc ccc gca gcc tcc cgg ggc tcc tgg tcc tct     3712
 Gly Pro Gly Gly Gly Ala Pro Ala Ala Ser Arg Gly Ser Trp Ser Ser
                1035                1040                1045

 gct ccc acg tca cgg gca tct tcg ccg ccc ccc cag ccc cag cca cca     3760
 Ala Pro Thr Ser Arg Ala Ser Ser Pro Pro Pro Gln Pro Gln Pro Pro
            1050                1055                1060

 cct ccc gca gcc agg cgg ctc agc tat gcc acg acg gtt aac atc cac     3808
 Pro Pro Ala Ala Arg Arg Leu Ser Tyr Ala Thr Thr Val Asn Ile His
        1065                1070                1075

 gtg ggc ggg ggt ggg cgg ctg cgg cca gcc aag gcc cag gtc cgg ttg     3856
 Val Gly Gly Gly Gly Arg Leu Arg Pro Ala Lys Ala Gln Val Arg Leu
    1080                1085                1090

 aac cac cct gct ctc ttg gcc tcc aca cag gaa tct atg ggc ctt cac     3904
 Asn His Pro Ala Leu Leu Ala Ser Thr Gln Glu Ser Met Gly Leu His
1095                1100                1105                1110

 agg gcc cag ggg gct cct gat gcc ccc ttc cac atg tga                 3943
 Arg Ala Gln Gly Ala Pro Asp Ala Pro Phe His Met 
                1115                1120





      <210> 294
      <211> 1114
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1052)

      <400> 294
 cccacgcgtc cgggattttc ttccaaaaat gcagacccat tttaattaag tttgtaatta     60

 accactgggg agggcaggcc ccctggattc ggtctgcttt cggagacact aacaag        116                                                                 
 atg gga gtc atg gcc atg ctg atg ctc ccc ctg ctg ctg ctg gga atc      164
 Met Gly Val Met Ala Met Leu Met Leu Pro Leu Leu Leu Leu Gly Ile
   1               5                  10                  15

 agc ggc ctc ctc ttc att tac caa gag gtg tcc agg ctg tgg tca aag      212
 Ser Gly Leu Leu Phe Ile Tyr Gln Glu Val Ser Arg Leu Trp Ser Lys
              20                  25                  30

 tca gct gtg cag aac aaa gtg gtg gtg atc acc gat gcc atc tca gga      260
 Ser Ala Val Gln Asn Lys Val Val Val Ile Thr Asp Ala Ile Ser Gly
          35                  40                  45

 ctg ggc aag gag tgt gct cgg gtg ttc cac aca ggt ggg gca agg ctg      308
 Leu Gly Lys Glu Cys Ala Arg Val Phe His Thr Gly Gly Ala Arg Leu
      50                  55                  60

 gtg ctg tgt gga aag aac tgg gag agg cta gag aac cta tat gat gcc      356
 Val Leu Cys Gly Lys Asn Trp Glu Arg Leu Glu Asn Leu Tyr Asp Ala
  65                  70                  75                  80

 ttg atc agc gtg gct gac ccc agc aag aca ttc acc cca aag ctg gtc      404
 Leu Ile Ser Val Ala Asp Pro Ser Lys Thr Phe Thr Pro Lys Leu Val
                  85                  90                  95

 ctg ttg gac ctc tca gac atc agc tgt gtc cca gat gtg gca aaa gaa      452
 Leu Leu Asp Leu Ser Asp Ile Ser Cys Val Pro Asp Val Ala Lys Glu
             100                 105                 110

 gtc ctg gat tgc tat ggc tgt gtg gac atc ctc atc aac aat gcc agt      500
 Val Leu Asp Cys Tyr Gly Cys Val Asp Ile Leu Ile Asn Asn Ala Ser
         115                 120                 125

 gtg aag gtg aag ggg cct gcc cat aag att tct ctg gag ctc gac aaa      548
 Val Lys Val Lys Gly Pro Ala His Lys Ile Ser Leu Glu Leu Asp Lys
     130                 135                 140

 aag atc atg gat gcc aat tac ttt ggc ccc atc aca ttg acg aaa gcc      596
 Lys Ile Met Asp Ala Asn Tyr Phe Gly Pro Ile Thr Leu Thr Lys Ala
 145                 150                 155                 160

 ctg ctt ccc aac atg atc tcc cgg aga aca ggc caa atc gtg tta gtg      644
 Leu Leu Pro Asn Met Ile Ser Arg Arg Thr Gly Gln Ile Val Leu Val
                 165                 170                 175

 aat aat atc caa ggg aag ttt gga atc ccg ttc cgt acg act tac gct      692
 Asn Asn Ile Gln Gly Lys Phe Gly Ile Pro Phe Arg Thr Thr Tyr Ala
             180                 185                 190

 gcc tcc aag cac gca gcc ctg ggc ttc ttt gac tgc ctc cga gcc gaa      740
 Ala Ser Lys His Ala Ala Leu Gly Phe Phe Asp Cys Leu Arg Ala Glu
         195                 200                 205

 gtg gag gaa tac gat gtt gtc atc agc acc gtg agc ccg act ttc atc      788
 Val Glu Glu Tyr Asp Val Val Ile Ser Thr Val Ser Pro Thr Phe Ile
     210                 215                 220

 cgg tcg tac cac gtg tat cca gag caa gga aac tgg gaa gct tcc att      836
 Arg Ser Tyr His Val Tyr Pro Glu Gln Gly Asn Trp Glu Ala Ser Ile
 225                 230                 235                 240

 tgg aaa ttc ttt ttc agg aag ctg acc tac ggc gtg cac cca gta gag      884
 Trp Lys Phe Phe Phe Arg Lys Leu Thr Tyr Gly Val His Pro Val Glu
                 245                 250                 255

 gtg gcg gag gag gtg atg cgc acc gtg cgg agg aag aag caa gag gtg      932
 Val Ala Glu Glu Val Met Arg Thr Val Arg Arg Lys Lys Gln Glu Val
             260                 265                 270

 ttt atg gcc aac ccc atc ccc aag gcc gcc gtg tac gtc cgc acc ttc      980
 Phe Met Ala Asn Pro Ile Pro Lys Ala Ala Val Tyr Val Arg Thr Phe
         275                 280                 285

 ttc ccg gag ttc ttt ttc gcc gtg gtg gcc tgt ggg gtg aag gag aag     1028
 Phe Pro Glu Phe Phe Phe Ala Val Val Ala Cys Gly Val Lys Glu Lys
     290                 295                 300

 ctc aat gtc ccg gag gag ggg taa ctgcaggagg ccaaatgggc caccccttgg    1082
 Leu Asn Val Pro Glu Glu Gly 
 305                 310

 aaataaaggt ttttctggca aaaaaaaaaa aa                                 1114




      <210> 295
      <211> 1492
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (79)..(1434)

      <400> 295
 ccacgccgcc gggcgaataa ctggattgaa atttataatt tcgtacagca acttgcggag     60

 agatttgtga gccctgaa  atg aga tta tct ttc att gtg ttt tct tct caa     111
                      Met Arg Leu Ser Phe Ile Val Phe Ser Ser Gln
                        1               5                  10

 gca act att att ttg cca tta act gga gac aga ggc aaa atc agt aaa      159
 Ala Thr Ile Ile Leu Pro Leu Thr Gly Asp Arg Gly Lys Ile Ser Lys
              15                  20                  25

 ggc ttg gag gat tta aaa cgt gtt agt cca gta gga gag aca tat atc      207
 Gly Leu Glu Asp Leu Lys Arg Val Ser Pro Val Gly Glu Thr Tyr Ile
          30                  35                  40

 cat gaa gga cta aag cta gcg aat gaa caa att cag aaa gca gga ggc      255
 His Glu Gly Leu Lys Leu Ala Asn Glu Gln Ile Gln Lys Ala Gly Gly
      45                  50                  55

 ttg aaa acc tcc agt atc ata att gct ctg aca gat ggc aag ttg gac      303
 Leu Lys Thr Ser Ser Ile Ile Ile Ala Leu Thr Asp Gly Lys Leu Asp
  60                  65                  70                  75

 ggt ctg gtg cca tca tat gca gag aaa gag gca aag ata tcc agg tca      351
 Gly Leu Val Pro Ser Tyr Ala Glu Lys Glu Ala Lys Ile Ser Arg Ser
                  80                  85                  90

 ctt ggg gct agt gtt tat tgt gtt ggg gtc ctt gat ttt gaa caa gca      399
 Leu Gly Ala Ser Val Tyr Cys Val Gly Val Leu Asp Phe Glu Gln Ala
              95                 100                 105

 cag ctt gaa aga att gct gat tcc aag gag caa gtt ttc cct gtc aaa      447
 Gln Leu Glu Arg Ile Ala Asp Ser Lys Glu Gln Val Phe Pro Val Lys
         110                 115                 120

 ggt gga ttt cag gct ctt aaa gga ata att aat tct ata cta gct cag      495
 Gly Gly Phe Gln Ala Leu Lys Gly Ile Ile Asn Ser Ile Leu Ala Gln
     125                 130                 135

 tca tgt act gaa atc cta gaa ttg cag ccc tca agt gtc tgt gtg ggg      543
 Ser Cys Thr Glu Ile Leu Glu Leu Gln Pro Ser Ser Val Cys Val Gly
 140                 145                 150                 155

 gag gaa ttt cag att gtc tta agt gga aga gga ttc atg ctg ggc agt      591
 Glu Glu Phe Gln Ile Val Leu Ser Gly Arg Gly Phe Met Leu Gly Ser
                 160                 165                 170

 cgg aat ggc agt gtt ctc tgc act tac act gta aat gaa aca tat aca      639
 Arg Asn Gly Ser Val Leu Cys Thr Tyr Thr Val Asn Glu Thr Tyr Thr
             175                 180                 185

 acg agt gta aaa cca gta agt gta cag ctt aat tct atg ctt tgt cct      687
 Thr Ser Val Lys Pro Val Ser Val Gln Leu Asn Ser Met Leu Cys Pro
         190                 195                 200

 gca cct atc ctg aat aaa gct gga gaa act ctt gat gtt tca gtg agc      735
 Ala Pro Ile Leu Asn Lys Ala Gly Glu Thr Leu Asp Val Ser Val Ser
     205                 210                 215

 ttt aat gga gga aaa tct gtc att tca gga tca tta att gtc aca gcc      783
 Phe Asn Gly Gly Lys Ser Val Ile Ser Gly Ser Leu Ile Val Thr Ala
 220                 225                 230                 235

 aca gaa tgt tct aac ggg atc gca gcc atc att gtt att ttg gtg tta      831
 Thr Glu Cys Ser Asn Gly Ile Ala Ala Ile Ile Val Ile Leu Val Leu
                 240                 245                 250

 ctg cta ctc ctg ggg atc ggt ttg atg tgg tgg ttt tgg ccc ctt tgc      879
 Leu Leu Leu Leu Gly Ile Gly Leu Met Trp Trp Phe Trp Pro Leu Cys
             255                 260                 265

 tgc aaa gtg gtt att aag gat cct cca cca cca ccc ccc cct gca cca      927
 Cys Lys Val Val Ile Lys Asp Pro Pro Pro Pro Pro Pro Pro Ala Pro
         270                 275                 280

 aaa gag gag gaa gaa gaa cct ttg cct act aaa aag tgg cca act gtg      975
 Lys Glu Glu Glu Glu Glu Pro Leu Pro Thr Lys Lys Trp Pro Thr Val
     285                 290                 295

 gat gct tcc tat tat ggg ggt cga ggg gtt gga gga att aaa aga atg     1023
 Asp Ala Ser Tyr Tyr Gly Gly Arg Gly Val Gly Gly Ile Lys Arg Met
 300                 305                 310                 315

 gag gtt cgt tgg ggt gat aaa gga tct act gag gaa ggt gca agg cta     1071
 Glu Val Arg Trp Gly Asp Lys Gly Ser Thr Glu Glu Gly Ala Arg Leu
                 320                 325                 330

 gag aaa gcc aaa aat gct gtg gtg aag att cct gaa gaa aca gag gaa     1119
 Glu Lys Ala Lys Asn Ala Val Val Lys Ile Pro Glu Glu Thr Glu Glu
             335                 340                 345

 ccc atc aag cct aga cca cct cga ccc aga ccc aca cac cag tct cct     1167
 Pro Ile Lys Pro Arg Pro Pro Arg Pro Arg Pro Thr His Gln Ser Pro
         350                 355                 360

 cag aca aaa tgg tac acc cca att aaa ggt cgt ctt gat gct ctc tgg     1215
 Gln Thr Lys Trp Tyr Thr Pro Ile Lys Gly Arg Leu Asp Ala Leu Trp
     365                 370                 375

 gct ttg ttg acg cgg cag tat gac cgg gtt tct ttg atg cga cct cag     1263
 Ala Leu Leu Thr Arg Gln Tyr Asp Arg Val Ser Leu Met Arg Pro Gln
 380                 385                 390                 395

 gaa gga gat gag ggc cgg tgc ata aac tta tcc cga gtt cca tct cag     1311
 Glu Gly Asp Glu Gly Arg Cys Ile Asn Leu Ser Arg Val Pro Ser Gln
                 400                 405                 410

 ttg atg ttc atc caa atg aac gac atc aag tgc att tca gaa gct ttt     1359
 Leu Met Phe Ile Gln Met Asn Asp Ile Lys Cys Ile Ser Glu Ala Phe
             415                 420                 425

 gga gag cag ctt aat tgc tct cac tcg gga aat gtt ttc tct gcc tta     1407
 Gly Glu Gln Leu Asn Cys Ser His Ser Gly Asn Val Phe Ser Ala Leu
         430                 435                 440

 tgc tat gct tgc acc aaa cat ttc taa acact tgtgtctgca tctccatggg     1459
 Cys Tyr Ala Cys Thr Lys His Phe 
     445                 450

 aggtgatgaa actcagtggt aactcatgat taa                                1492




      <210> 296
      <211> 3656
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(2628)

      <400> 296
 ctggtagaca ccaaacttaa gcaagaatta tcaagtgagg aagaaggtga tgctaaaaag     60

 ggtgtgtcaa gtgtcactat tatgccggaa gccaatggcc atttgaaata tgacaaggtt    120

 gatgatttat gtggctattt ggaggaagaa gaggaaagta ccacataaat catcaaactt    180

 gtcactatt    atg ccg gaa gcc aat ggc cat ttg aaa tat gac aag gtt     228
              Met Pro Glu Ala Asn Gly His Leu Lys Tyr Asp Lys Val
                1               5                  10

 gat gat tta tgt ggc tat ttg gag gaa gaa gag gaa agt acc acc gtt      276
 Asp Asp Leu Cys Gly Tyr Leu Glu Glu Glu Glu Glu Ser Thr Thr Val
      15                  20                  25

 caa aaa ttt ata gac cat ctg ctc cat aaa aat gtg gta gat tct gca      324
 Gln Lys Phe Ile Asp His Leu Leu His Lys Asn Val Val Asp Ser Ala
  30                  35                  40                  45

 atg atg gaa gat ctt gga agg aag gaa aac caa gac aag aag cag cag      372
 Met Met Glu Asp Leu Gly Arg Lys Glu Asn Gln Asp Lys Lys Gln Gln
                  50                  55                  60

 aag gat cct cgt ctt acc atg gag atg aga cat aag cag gta aaa gaa      420
 Lys Asp Pro Arg Leu Thr Met Glu Met Arg His Lys Gln Val Lys Glu
              65                  70                  75

 aat cgc tta aga cgt gag aaa gaa ctg gag tac cag aga ata gaa aag      468
 Asn Arg Leu Arg Arg Glu Lys Glu Leu Glu Tyr Gln Arg Ile Glu Lys
          80                  85                  90

 acc ctg aaa aaa tcg gcc ttc ttg gag gct cag tgt ctg gtg caa gaa      516
 Thr Leu Lys Lys Ser Ala Phe Leu Glu Ala Gln Cys Leu Val Gln Glu
      95                 100                 105

 gag aag aaa agg aag gct ctg gag gcc aag aaa gag gaa gag gag att      564
 Glu Lys Lys Arg Lys Ala Leu Glu Ala Lys Lys Glu Glu Glu Glu Ile
 110                 115                 120                 125

 caa agg gag atg gtg aag ctg cgg agg gag ata att gag agg aga cgc      612
 Gln Arg Glu Met Val Lys Leu Arg Arg Glu Ile Ile Glu Arg Arg Arg
                 130                 135                 140

 act gtg aaa gca gca tgg aaa ata gag aag aaa agg caa gaa gag aat      660
 Thr Val Lys Ala Ala Trp Lys Ile Glu Lys Lys Arg Gln Glu Glu Asn
             145                 150                 155

 tct caa aat agt tca gaa aaa gtc atg ttt caa agt act cac att ctt      708
 Ser Gln Asn Ser Ser Glu Lys Val Met Phe Gln Ser Thr His Ile Leu
         160                 165                 170

 cca gat gag gaa aaa atg gtg aag gaa aga aaa agg aaa ttg aaa gaa      756
 Pro Asp Glu Glu Lys Met Val Lys Glu Arg Lys Arg Lys Leu Lys Glu
     175                 180                 185

 gta tta atc caa act ttc aaa gaa aat caa cag tgt caa aaa cgg tat      804
 Val Leu Ile Gln Thr Phe Lys Glu Asn Gln Gln Cys Gln Lys Arg Tyr
 190                 195                 200                 205

 ttc gct gcc tgg cac aag ctg att ctt gat cat agg att aag ctg ggg      852
 Phe Ala Ala Trp His Lys Leu Ile Leu Asp His Arg Ile Lys Leu Gly
                 210                 215                 220

 aaa gct ggg acc ctg tct gac tgg aag att cag ctg aag gtc ctg cgg      900
 Lys Ala Gly Thr Leu Ser Asp Trp Lys Ile Gln Leu Lys Val Leu Arg
             225                 230                 235

 gcc tgg aga gac tac aca aga ttc cag aag ttg gag cgg gag act caa      948
 Ala Trp Arg Asp Tyr Thr Arg Phe Gln Lys Leu Glu Arg Glu Thr Gln
         240                 245                 250

 gcc ttg gaa aat gat ctt agg gaa gaa aac aga aaa caa caa ctg gcc      996
 Ala Leu Glu Asn Asp Leu Arg Glu Glu Asn Arg Lys Gln Gln Leu Ala
     255                 260                 265

 act gag tat aac cgg aaa caa gtt ctc cga cac tgc ttt aca gaa tgg     1044
 Thr Glu Tyr Asn Arg Lys Gln Val Leu Arg His Cys Phe Thr Glu Trp
 270                 275                 280                 285

 cag cat tgg cat ggc gcc gag ctc ctg aag aga gag ctg gct ctc aca     1092
 Gln His Trp His Gly Ala Glu Leu Leu Lys Arg Glu Leu Ala Leu Thr
                 290                 295                 300

 aaa gag gaa act agg aag aag atg gat gca ctg ctg cag gca gca tca     1140
 Lys Glu Glu Thr Arg Lys Lys Met Asp Ala Leu Leu Gln Ala Ala Ser
             305                 310                 315

 ctg ggg aaa ctc agt gcc aat ggg tta tca ggc atc agt cta cct gag     1188
 Leu Gly Lys Leu Ser Ala Asn Gly Leu Ser Gly Ile Ser Leu Pro Glu
         320                 325                 330

 gag gca aca gcc atg gtg ggt cca cca gta aaa aat gga cag gag act     1236
 Glu Ala Thr Ala Met Val Gly Pro Pro Val Lys Asn Gly Gln Glu Thr
     335                 340                 345

 gct gtg ccc cct ttg tgg gaa aag cct ccc ttg gga agc agt ggt tgt     1284
 Ala Val Pro Pro Leu Trp Glu Lys Pro Pro Leu Gly Ser Ser Gly Cys
 350                 355                 360                 365

 atg ctc agt cct ccc ctg gga aga aca aca aca ggc aac ttg cag ggt     1332
 Met Leu Ser Pro Pro Leu Gly Arg Thr Thr Thr Gly Asn Leu Gln Gly
                 370                 375                 380

 tcc ctt cag aat gtc tct ctg agt gca cct ggc aat aag cag cac aag     1380
 Ser Leu Gln Asn Val Ser Leu Ser Ala Pro Gly Asn Lys Gln His Lys
             385                 390                 395

 acc ctg ggt gct gaa ccc tct caa cag cct ggc agc aac gag aca ctc     1428
 Thr Leu Gly Ala Glu Pro Ser Gln Gln Pro Gly Ser Asn Glu Thr Leu
         400                 405                 410

 aga act acc agc cag aaa gca gaa ccg ctt tgc ttg ggt cat ttc cac     1476
 Arg Thr Thr Ser Gln Lys Ala Glu Pro Leu Cys Leu Gly His Phe His
     415                 420                 425

 aac cgc cat gtc ttc cag caa cag ctg att gag aag caa aag aag aaa     1524
 Asn Arg His Val Phe Gln Gln Gln Leu Ile Glu Lys Gln Lys Lys Lys
 430                 435                 440                 445

 ctt cag gaa cag cag aaa aca att ctc gag ctg aag aaa aac ctg cag     1572
 Leu Gln Glu Gln Gln Lys Thr Ile Leu Glu Leu Lys Lys Asn Leu Gln
                 450                 455                 460

 ctg gca gag gct cag tgg gca gca gag cat gcc tta gca gtc aca gaa     1620
 Leu Ala Glu Ala Gln Trp Ala Ala Glu His Ala Leu Ala Val Thr Glu
             465                 470                 475

 gca cag agc cac ctg ctg tca aag ccc aga gaa gag gaa cca aga acc     1668
 Ala Gln Ser His Leu Leu Ser Lys Pro Arg Glu Glu Glu Pro Arg Thr
         480                 485                 490

 tgc cag atg ctt gtg aat tca cct gtt gct tcc cct ggg act gaa ggc     1716
 Cys Gln Met Leu Val Asn Ser Pro Val Ala Ser Pro Gly Thr Glu Gly
     495                 500                 505

 aga agt gac tcc cga aat tct ctt tct gga ctc aga agg aaa cca aag     1764
 Arg Ser Asp Ser Arg Asn Ser Leu Ser Gly Leu Arg Arg Lys Pro Lys
 510                 515                 520                 525

 caa ttg atg aca ccg cat ccc ata cta aaa gct atg gaa gag aga gca     1812
 Gln Leu Met Thr Pro His Pro Ile Leu Lys Ala Met Glu Glu Arg Ala
                 530                 535                 540

 att caa cga gct gaa tgt agg cgg atc ttg gca gag aag aag aaa aaa     1860
 Ile Gln Arg Ala Glu Cys Arg Arg Ile Leu Ala Glu Lys Lys Lys Lys
             545                 550                 555

 caa gaa gaa gaa aaa ttg gcc cag tta aag gcc caa gag gag gaa cgt     1908
 Gln Glu Glu Glu Lys Leu Ala Gln Leu Lys Ala Gln Glu Glu Glu Arg
         560                 565                 570

 cag aaa agg gag gca gaa gaa aag gag gca cag ctt gaa aga aaa cga     1956
 Gln Lys Arg Glu Ala Glu Glu Lys Glu Ala Gln Leu Glu Arg Lys Arg
     575                 580                 585

 gaa gag aag aga ctg aag aaa atg aaa gaa ctt gag aag cag aag aga     2004
 Glu Glu Lys Arg Leu Lys Lys Met Lys Glu Leu Glu Lys Gln Lys Arg
 590                 595                 600                 605

 att aag agg aac cag cag ctg gaa gca ata gcc aaa gaa cat tat gaa     2052
 Ile Lys Arg Asn Gln Gln Leu Glu Ala Ile Ala Lys Glu His Tyr Glu
                 610                 615                 620

 agg gtc ttg cta agg aaa aaa ggt cta gag cct tgg aag aga ttg aga     2100
 Arg Val Leu Leu Arg Lys Lys Gly Leu Glu Pro Trp Lys Arg Leu Arg
             625                 630                 635

 atg caa agc aaa caa aac atc cag gtg gca gaa gaa cat tac tct ttg     2148
 Met Gln Ser Lys Gln Asn Ile Gln Val Ala Glu Glu His Tyr Ser Leu
         640                 645                 650

 ttc ctg cag agg aaa tac atg ctg acg tgg ttc cag cgt agt cag gaa     2196
 Phe Leu Gln Arg Lys Tyr Met Leu Thr Trp Phe Gln Arg Ser Gln Glu
     655                 660                 665

 agt ctg gct aga aag atg gcc cag gct gat caa ttt tat tcc caa ata     2244
 Ser Leu Ala Arg Lys Met Ala Gln Ala Asp Gln Phe Tyr Ser Gln Ile
 670                 675                 680                 685

 ctg ctt aag aga gtc atc cag agc tgg cta cag tac gtg att gat ctg     2292
 Leu Leu Lys Arg Val Ile Gln Ser Trp Leu Gln Tyr Val Ile Asp Leu
                 690                 695                 700

 cag gaa gaa gta aga aaa ttt tgt gta cat ttt ctt caa aag aag att     2340
 Gln Glu Glu Val Arg Lys Phe Cys Val His Phe Leu Gln Lys Lys Ile
             705                 710                 715

 ttc agg gcc tgg ttt aac atg gtc agg gag gtg aag atc gat tct cag     2388
 Phe Arg Ala Trp Phe Asn Met Val Arg Glu Val Lys Ile Asp Ser Gln
         720                 725                 730

 ggc aag cat gag att gca gcg gag cac agt gac agg agg atc ctc tgg     2436
 Gly Lys His Glu Ile Ala Ala Glu His Ser Asp Arg Arg Ile Leu Trp
     735                 740                 745

 atc acc ctt cgg aca tgg aag aag ttt gta aaa ttt atg aaa gag gaa     2484
 Ile Thr Leu Arg Thr Trp Lys Lys Phe Val Lys Phe Met Lys Glu Glu
 750                 755                 760                 765

 aga gta aaa gaa gaa agg cga cag caa ctt cgt agg aag gta gtt gaa     2532
 Arg Val Lys Glu Glu Arg Arg Gln Gln Leu Arg Arg Lys Val Val Glu
                 770                 775                 780

 att ctt cca gac ttc cag gta cct gga agg tac cac gag cta tat cag     2580
 Ile Leu Pro Asp Phe Gln Val Pro Gly Arg Tyr His Glu Leu Tyr Gln
             785                 790                 795

 caa tca gat act tgg tcc ttg agt aag aca agt ctg gtg aac gaa tga     2628
 Gln Ser Asp Thr Trp Ser Leu Ser Lys Thr Ser Leu Val Asn Glu 
         800                 805                 810

 gccagattag tgtaatattt aggacaggaa gctcgactag tctgtatgtg tgttatctcc   2688

 acccacccac acacatacat acatacacct ggtttattct ctacgagcta cttcttagat   2748

 caaaggaatt attttgagaa tttttattcc cttctttgac ttttcctgga ttgctagtca   2808

 ttcactatag catttatcac agtgggatca tccaaaggaa cattctagag atcgtctgtt   2868

 caaatatatc ctatatattt ttagcatagt aaactttaaa aaggacaagt gtttgcctga   2928

 ctgagcctgt gaagaaaatg tgtccgtata gcacgacagg agttgctgat gtgaccttaa   2988

 tgaaacagaa ataaacaggg gtgagtgctc ggaaaggaag ggcgggccaa ggcactcagc   3048

 cttctagtgc agtagcatca gtgacacgca ccccaccaga cctcgtccac tttcaccacc   3108

 cctgaaggca gaccatgtat gaaaaggttc tctacacagc tgctgcagag gacagcagct   3168

 tatcctgatt tcagagaaac tgaggcacca gagatgcttc tcttccgtgc accttgataa   3228

 gcatgaagga cattccaaaa ggtaataact ctatcatgac agtccagcaa ttcattaaat   3288

 tatctgttca tgctcccacc tgcaactgct gaataataca ctcagtttgt cttctagtac   3348

 tcagctcagt ttgatctaga tattgagata cctatcttga attcaaagaa tgttttcatc   3408

 tttaagatgc tataaagact gataaaatgc tctcttctat gaattgtgtt agagaattac   3468

 ctgctagaaa aataattttt cattataaaa tacacattta ttatataaca aattcaagta   3528

 gtccataaat gcatatggta aaatgagaaa gtcctgtgca gtcctgagat gattactctt   3588

 atttggtgtg ctgaaaattt gagttgacaa aataaaattc tgtggttttt taagtgaaaa   3648

 aaaaaaaa                                                            3656




      <210> 297
      <211> 3176
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(3129)

      <400> 297
  atg tac tgt ggt gtc ctg gtg gga tcc tgg gac agg aag agg aaa tac      48
  Met Tyr Cys Gly Val Leu Val Gly Ser Trp Asp Arg Lys Arg Lys Tyr
    1               5                  10                  15

 tgg tgg aag ctg aac aaa gcg tgg cat ttg gag aac act aag gtg ctg       96
 Trp Trp Lys Leu Asn Lys Ala Trp His Leu Glu Asn Thr Lys Val Leu
              20                  25                  30

 atg ctg gca tcc tcc tcg tgg atg cca gtc att gaa ttt acg gtc tac      144
 Met Leu Ala Ser Ser Ser Trp Met Pro Val Ile Glu Phe Thr Val Tyr
          35                  40                  45

 cct aaa tcc aga tgg ctt cat cct gag atg ctt agc cac gtc tcc aat      192
 Pro Lys Ser Arg Trp Leu His Pro Glu Met Leu Ser His Val Ser Asn
      50                  55                  60

 gac cct att tcc aaa att tta gac agg gtc ttt gag cgc tca cct gtc      240
 Asp Pro Ile Ser Lys Ile Leu Asp Arg Val Phe Glu Arg Ser Pro Val
  65                  70                  75                  80

 ttg gct ctc tgg aat gga ttc acg ttc atg gca gag gct gtg aac cct      288
 Leu Ala Leu Trp Asn Gly Phe Thr Phe Met Ala Glu Ala Val Asn Pro
                  85                  90                  95

 gag ttt acg gtc atc ctt gtc agc tcc tca ctc agt gac cgg gac cag      336
 Glu Phe Thr Val Ile Leu Val Ser Ser Ser Leu Ser Asp Arg Asp Gln
             100                 105                 110

 agc cta ttc ctc agc gca gac gaa ggc gcc acc ttt cag aag cag ccc      384
 Ser Leu Phe Leu Ser Ala Asp Glu Gly Ala Thr Phe Gln Lys Gln Pro
         115                 120                 125

 att ccc ttc ttc gtg gaa act ctg att ttc cac cct aag gag gag gac      432
 Ile Pro Phe Phe Val Glu Thr Leu Ile Phe His Pro Lys Glu Glu Asp
     130                 135                 140

 aag gtc ctc gcc tac aca aag gag agc aag ctc tac gtg tca tct gac      480
 Lys Val Leu Ala Tyr Thr Lys Glu Ser Lys Leu Tyr Val Ser Ser Asp
 145                 150                 155                 160

 ttg ggg aaa aag tgg aca ctt ctg caa gag cga gtg acc aaa gac cac      528
 Leu Gly Lys Lys Trp Thr Leu Leu Gln Glu Arg Val Thr Lys Asp His
                 165                 170                 175

 gtg ttc tgg tct gtg tct ggg gtg gac gct gac cct gac ttg gtc cac      576
 Val Phe Trp Ser Val Ser Gly Val Asp Ala Asp Pro Asp Leu Val His
             180                 185                 190

 gtg gaa gcc caa gac ctc ggt gga gat ttt cgg tac gtc acc tgc gca      624
 Val Glu Ala Gln Asp Leu Gly Gly Asp Phe Arg Tyr Val Thr Cys Ala
         195                 200                 205

 atc cac aat tgc tcc gag aag atg ctg aca gcc cca ttc gca ggc ccc      672
 Ile His Asn Cys Ser Glu Lys Met Leu Thr Ala Pro Phe Ala Gly Pro
     210                 215                 220

 att gac cac ggg tct ctg acc gtg cag gac gat tac atc ttc ttt aag      720
 Ile Asp His Gly Ser Leu Thr Val Gln Asp Asp Tyr Ile Phe Phe Lys
 225                 230                 235                 240

 gca aca tca gca aac cag aca aaa tac tac gtc tct tat cgt cga aat      768
 Ala Thr Ser Ala Asn Gln Thr Lys Tyr Tyr Val Ser Tyr Arg Arg Asn
                 245                 250                 255

 gaa ttt gtc ctg atg aag ctg ccg aag tat gca ttg cca aag gat ctg      816
 Glu Phe Val Leu Met Lys Leu Pro Lys Tyr Ala Leu Pro Lys Asp Leu
             260                 265                 270

 cag atc atc agc acg gac gag agt cag gtg ttc gtg gcg gtg cag gag      864
 Gln Ile Ile Ser Thr Asp Glu Ser Gln Val Phe Val Ala Val Gln Glu
         275                 280                 285

 tgg tac cag atg gac acc tac aac ctg tac cag tcg gac cca cgg ggc      912
 Trp Tyr Gln Met Asp Thr Tyr Asn Leu Tyr Gln Ser Asp Pro Arg Gly
     290                 295                 300

 gtg cgc tac gcg ctg gtg ctg cag gac gtg cgc agc tca cgg cag gcg      960
 Val Arg Tyr Ala Leu Val Leu Gln Asp Val Arg Ser Ser Arg Gln Ala
 305                 310                 315                 320

 gag gag agc gtg ctc atc gac atc ctg gag gtc aga ggg gtg aaa gga     1008
 Glu Glu Ser Val Leu Ile Asp Ile Leu Glu Val Arg Gly Val Lys Gly
                 325                 330                 335

 gtc ttc ctg gca aac caa aaa att gat ggg aaa gtg atg acg ctt ata     1056
 Val Phe Leu Ala Asn Gln Lys Ile Asp Gly Lys Val Met Thr Leu Ile
             340                 345                 350

 acc tac aac aag ggc cgc gac tgg gat tac ctg agg cca ccc agc atg     1104
 Thr Tyr Asn Lys Gly Arg Asp Trp Asp Tyr Leu Arg Pro Pro Ser Met
         355                 360                 365

 gac atg aat gga aaa cca acc aac tgc aag cct cca gac tgc cac ctg     1152
 Asp Met Asn Gly Lys Pro Thr Asn Cys Lys Pro Pro Asp Cys His Leu
     370                 375                 380

 cac ctg cac ctg cgc tgg gca gac aac ccc tac gta tca ggc acc gtg     1200
 His Leu His Leu Arg Trp Ala Asp Asn Pro Tyr Val Ser Gly Thr Val
 385                 390                 395                 400

 cac acc aag gac acc gcc cca ggc ctc atc atg ggt gca ggt aac ctg     1248
 His Thr Lys Asp Thr Ala Pro Gly Leu Ile Met Gly Ala Gly Asn Leu
                 405                 410                 415

 ggc tca cag ctg gtg gaa tat aaa gaa gaa atg tac atc acg tca gac     1296
 Gly Ser Gln Leu Val Glu Tyr Lys Glu Glu Met Tyr Ile Thr Ser Asp
             420                 425                 430

 tgt ggt cac acc tgg cgg cag gtg ttt gag gaa gag cat cac atc ctg     1344
 Cys Gly His Thr Trp Arg Gln Val Phe Glu Glu Glu His His Ile Leu
         435                 440                 445

 tac ctg gac cac ggc ggc gtg atc gtg gcc atc aaa gac acc tcc atc     1392
 Tyr Leu Asp His Gly Gly Val Ile Val Ala Ile Lys Asp Thr Ser Ile
     450                 455                 460

 cct ttg aag atc ctc aag ttc agt gtg gac gag ggc ctc acc tgg agc     1440
 Pro Leu Lys Ile Leu Lys Phe Ser Val Asp Glu Gly Leu Thr Trp Ser
 465                 470                 475                 480

 acg cac aac ttc acc agc acc tcg gtg ttt gtg gac ggg ctg ctg agt     1488
 Thr His Asn Phe Thr Ser Thr Ser Val Phe Val Asp Gly Leu Leu Ser
                 485                 490                 495

 gag cca ggg gac gag acg ctg gtc atg acg gtc ttt ggc cac atc agc     1536
 Glu Pro Gly Asp Glu Thr Leu Val Met Thr Val Phe Gly His Ile Ser
             500                 505                 510

 ttc cgc tcc gac tgg gag ctg gtc aag gtg gac ttc cgg ccc tca ttc     1584
 Phe Arg Ser Asp Trp Glu Leu Val Lys Val Asp Phe Arg Pro Ser Phe
         515                 520                 525

 tcc agg cag tgc ggc gag gag gac tac agc tcc tgg gag ctc tcc aac     1632
 Ser Arg Gln Cys Gly Glu Glu Asp Tyr Ser Ser Trp Glu Leu Ser Asn
     530                 535                 540

 ctg cag ggc gac cgc tgt atc atg ggc cag cag aga agt ttc cgg aaa     1680
 Leu Gln Gly Asp Arg Cys Ile Met Gly Gln Gln Arg Ser Phe Arg Lys
 545                 550                 555                 560

 aga aag tcc acg tcc tgg tgc atc aag ggg agg agc ttc acg tcg gcg     1728
 Arg Lys Ser Thr Ser Trp Cys Ile Lys Gly Arg Ser Phe Thr Ser Ala
                 565                 570                 575

 ctc acg tcc cgc gtg tgc gag tgc cgg gac tcg gac ttc ctg tgc gac     1776
 Leu Thr Ser Arg Val Cys Glu Cys Arg Asp Ser Asp Phe Leu Cys Asp
             580                 585                 590

 tac gga ttt gag cgc tcc ccc tcc tca gag tcc agc acc aac aag tgc     1824
 Tyr Gly Phe Glu Arg Ser Pro Ser Ser Glu Ser Ser Thr Asn Lys Cys
         595                 600                 605

 tct gcc aac ttc tgg ttt aac cca ttg tcc ccg cct gac gac tgt gcc     1872
 Ser Ala Asn Phe Trp Phe Asn Pro Leu Ser Pro Pro Asp Asp Cys Ala
     610                 615                 620

 cta ggc cag acc tac acc agc agc ctt ggg tac cgg aaa gtg gtg tcc     1920
 Leu Gly Gln Thr Tyr Thr Ser Ser Leu Gly Tyr Arg Lys Val Val Ser
 625                 630                 635                 640

 aac gtg tgt gag ggt ggg gtg gac atg cag cag agt cag gtg cag ctg     1968
 Asn Val Cys Glu Gly Gly Val Asp Met Gln Gln Ser Gln Val Gln Leu
                 645                 650                 655

 cag tgc ccc ctc acg ccg ccc cgg ggc ctg cag gtc agc att caa ggc     2016
 Gln Cys Pro Leu Thr Pro Pro Arg Gly Leu Gln Val Ser Ile Gln Gly
             660                 665                 670

 gag gcg gtg gcc gtg cgg cct gga gag gac gtc ctg ttt gtg gtg cgg     2064
 Glu Ala Val Ala Val Arg Pro Gly Glu Asp Val Leu Phe Val Val Arg
         675                 680                 685

 cag gag cag ggt gat gtc ctg act acc aag tac cag gta gac ctt ggg     2112
 Gln Glu Gln Gly Asp Val Leu Thr Thr Lys Tyr Gln Val Asp Leu Gly
     690                 695                 700

 gac ggc ttc aag gcc atg tac gtg aac ctt aca ctg acc ggg gag ccc     2160
 Asp Gly Phe Lys Ala Met Tyr Val Asn Leu Thr Leu Thr Gly Glu Pro
 705                 710                 715                 720

 atc cgg cac cgc tac gag agc ccc ggc atc tac cgc gtg tcc gtc agg     2208
 Ile Arg His Arg Tyr Glu Ser Pro Gly Ile Tyr Arg Val Ser Val Arg
                 725                 730                 735

 gca gag aac acg gca ggc cac gat gag gcg gtg ctc ttt gtc cag gtc     2256
 Ala Glu Asn Thr Ala Gly His Asp Glu Ala Val Leu Phe Val Gln Val
             740                 745                 750

 aac tcc ccc ctg cag gcc ctc tac ctg gag gtg gtt cct gtc att ggc     2304
 Asn Ser Pro Leu Gln Ala Leu Tyr Leu Glu Val Val Pro Val Ile Gly
         755                 760                 765

 ctc aac cag gag gtg aac ctc aca gct gtg ctg ctt ccc ttg aac cct     2352
 Leu Asn Gln Glu Val Asn Leu Thr Ala Val Leu Leu Pro Leu Asn Pro
     770                 775                 780

 aac ctc acc gtc ttc tac tgg tgg atc ggc cac agc ctg cag ccc ctc     2400
 Asn Leu Thr Val Phe Tyr Trp Trp Ile Gly His Ser Leu Gln Pro Leu
 785                 790                 795                 800

 ctt tcc ctg gat aat tct gtg aca acg cgg ttt tcg gac acg ggc gac     2448
 Leu Ser Leu Asp Asn Ser Val Thr Thr Arg Phe Ser Asp Thr Gly Asp
                 805                 810                 815

 gtg cgt gtg acg gtg cag gcc gcc tgt ggg aac tcg gtg ctg cag gac     2496
 Val Arg Val Thr Val Gln Ala Ala Cys Gly Asn Ser Val Leu Gln Asp
             820                 825                 830

 tcc agg gtc ctc cgt gtg ctg gat caa ttt caa gtc atg cct ctg cag     2544
 Ser Arg Val Leu Arg Val Leu Asp Gln Phe Gln Val Met Pro Leu Gln
         835                 840                 845

 ttt tcc aag gag ctg gat gcc tac aac ccc aac acc cct gag tgg agg     2592
 Phe Ser Lys Glu Leu Asp Ala Tyr Asn Pro Asn Thr Pro Glu Trp Arg
     850                 855                 860

 gaa gac gtg ggc ctg gtg gtc acc cgg ctg ctc tcc aag gag acc agc     2640
 Glu Asp Val Gly Leu Val Val Thr Arg Leu Leu Ser Lys Glu Thr Ser
 865                 870                 875                 880

 gtc cct cag gag ctt ctg gtg act gtg gtg aag ccg ggg ctg ccc act     2688
 Val Pro Gln Glu Leu Leu Val Thr Val Val Lys Pro Gly Leu Pro Thr
                 885                 890                 895

 ttg gcc gat ctg tac gtg ctc ctg ccc cct ccc agg ccc aca agg aag     2736
 Leu Ala Asp Leu Tyr Val Leu Leu Pro Pro Pro Arg Pro Thr Arg Lys
             900                 905                 910

 agg agc ctc tcg agt gat aag agg ctc gcc gcc atc cag cag gtg ctg     2784
 Arg Ser Leu Ser Ser Asp Lys Arg Leu Ala Ala Ile Gln Gln Val Leu
         915                 920                 925

 aac gca cag aag atc agc ttc ctc ctg cga ggc gga gtc cgg gtc ctg     2832
 Asn Ala Gln Lys Ile Ser Phe Leu Leu Arg Gly Gly Val Arg Val Leu
     930                 935                 940

 gtg gcc ctg cgg gac aca ggc aca ggt gct gag cag ctg ggc ggc ggt     2880
 Val Ala Leu Arg Asp Thr Gly Thr Gly Ala Glu Gln Leu Gly Gly Gly
 945                 950                 955                 960

 ggc ggc tac tgg gcg gta gtg gtg ctg ttt gtc atc ggg ctc ttc gca     2928
 Gly Gly Tyr Trp Ala Val Val Val Leu Phe Val Ile Gly Leu Phe Ala
                 965                 970                 975

 gcg gga gcc ttc atc ctc tac aag ttc aaa agg aaa cgg cca ggc agg     2976
 Ala Gly Ala Phe Ile Leu Tyr Lys Phe Lys Arg Lys Arg Pro Gly Arg
             980                 985                 990

 acc gtg tac gcc caa atg cac aac gag aag gag cag gag atg acc agc     3024
 Thr Val Tyr Ala Gln Met His Asn Glu Lys Glu Gln Glu Met Thr Ser
         995                1000                1005

 cct gtg agt cac agt gag gac gtc cag ggc gct gtc cag ggc aac cac     3072
 Pro Val Ser His Ser Glu Asp Val Gln Gly Ala Val Gln Gly Asn His
    1010                1015                1020

 tca ggc gtg gtc ctg agc atc aac tcc cga gag atg cac agc tac ctg     3120
 Ser Gly Val Val Leu Ser Ile Asn Ser Arg Glu Met His Ser Tyr Leu
1025                1030                1035                1040

 gtg agc tga tgccacc ccagcatctg tcttttcacc cacggagggc acagaaccac     3176
 Val Ser 






      <210> 298
      <211> 1820
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (431)..(1777)

      <400> 298
 tttcgacgat ttcgtagcgc ccccggaggc gctaagcttg cgctctgagg cggtttccgt     60

 tcccggacgt ttggactctg tcctggagaa ggggaaggaa aaagtaagac gtagaagtac    120

 actgagactt cgtcacacat aaaacaagca cgacaaagaa agagggcgcg aagggactcc    180

 tggaagaaat tgagtctaca tttaagatca ccctaaaagt agtgacggcc tcttcattac    240

 tccaaacccc agatttaagt cggtaggacg tcttcgcgtt gacttgtggg gaatgtagtt    300

 tcgatgctgc cggcgcgttt tgtttgcgac agaaactaca acccccaggg gccaccgcga    360

 cgttgcctgt gggtgcccgc gaaccaacgg ttagcggtgg caggggctga ctgagagcgt    420

 ctgcttgata   atg gat tct gaa tta atg cat agt ata gta gga agc tat     469
              Met Asp Ser Glu Leu Met His Ser Ile Val Gly Ser Tyr
                1               5                  10

 cat aaa cct cca gaa aga gta ttt gtt ccc tca ttc acc cag aat gaa      517
 His Lys Pro Pro Glu Arg Val Phe Val Pro Ser Phe Thr Gln Asn Glu
      15                  20                  25

 cca tct cag aat tgc cat cct gca aac tta gaa gtt acc tct cct aag      565
 Pro Ser Gln Asn Cys His Pro Ala Asn Leu Glu Val Thr Ser Pro Lys
  30                  35                  40                  45

 ata ctt cat agc cca aat agc caa gct ctt att tta gcc tta aaa act      613
 Ile Leu His Ser Pro Asn Ser Gln Ala Leu Ile Leu Ala Leu Lys Thr
                  50                  55                  60

 ctt cag gaa aaa att cat cgt tta gag ctg gag aga aca caa gct gaa      661
 Leu Gln Glu Lys Ile His Arg Leu Glu Leu Glu Arg Thr Gln Ala Glu
              65                  70                  75

 gat aac ctg aac att ctt tcc aga gaa gca gca cag tat aag aag gcc      709
 Asp Asn Leu Asn Ile Leu Ser Arg Glu Ala Ala Gln Tyr Lys Lys Ala
          80                  85                  90

 tta gag aat gaa aca aat gag aga aat ctg gca cac cag gag ctg ata      757
 Leu Glu Asn Glu Thr Asn Glu Arg Asn Leu Ala His Gln Glu Leu Ile
      95                 100                 105

 aag cag aaa aaa gat ata agt ata cag tta agc tca gcc cag tct cgt      805
 Lys Gln Lys Lys Asp Ile Ser Ile Gln Leu Ser Ser Ala Gln Ser Arg
 110                 115                 120                 125

 tgt act ctt cta gag aag caa cta gaa tat aca aag aga atg gtt ctc      853
 Cys Thr Leu Leu Glu Lys Gln Leu Glu Tyr Thr Lys Arg Met Val Leu
                 130                 135                 140

 aac gta gag cga gaa aag aac atg atc cta gaa caa cag gcc cag ctt      901
 Asn Val Glu Arg Glu Lys Asn Met Ile Leu Glu Gln Gln Ala Gln Leu
             145                 150                 155

 cag agg gaa aaa gaa caa gat cag atg aag ctg tat gca aaa ctt gaa      949
 Gln Arg Glu Lys Glu Gln Asp Gln Met Lys Leu Tyr Ala Lys Leu Glu
         160                 165                 170

 aag ctt gat gtc tta gaa aaa gag tgt ttc aga ctt aca aca act cag      997
 Lys Leu Asp Val Leu Glu Lys Glu Cys Phe Arg Leu Thr Thr Thr Gln
     175                 180                 185

 aaa act gct gag gac aag att aaa cat tta gaa gaa aaa ctt aag gaa     1045
 Lys Thr Ala Glu Asp Lys Ile Lys His Leu Glu Glu Lys Leu Lys Glu
 190                 195                 200                 205

 gaa gaa cat cag cgt aag cta ttt caa gac aaa gct tct gag aaa act     1093
 Glu Glu His Gln Arg Lys Leu Phe Gln Asp Lys Ala Ser Glu Lys Thr
                 210                 215                 220

 aaa tgt ata aag aga cga cca cct tgg caa att tgt tca aag ttt gga     1141
 Lys Cys Ile Lys Arg Arg Pro Pro Trp Gln Ile Cys Ser Lys Phe Gly
             225                 230                 235

 gca ctg cct ttt gtg gct gaa aag tct acc agt gca agc tgt tct gtg     1189
 Ala Leu Pro Phe Val Ala Glu Lys Ser Thr Ser Ala Ser Cys Ser Val
         240                 245                 250

 aat gca agt atg caa aac ttt ttg cag atg agg caa cat cgt gac cca     1237
 Asn Ala Ser Met Gln Asn Phe Leu Gln Met Arg Gln His Arg Asp Pro
     255                 260                 265

 cat atc ctt cag aaa cct ttt aac gtg act gag act aga tgt ctc ccc     1285
 His Ile Leu Gln Lys Pro Phe Asn Val Thr Glu Thr Arg Cys Leu Pro
 270                 275                 280                 285

 aag cct tct aga aca act tcc tgg tgt aaa gct att cct cct gac tca     1333
 Lys Pro Ser Arg Thr Thr Ser Trp Cys Lys Ala Ile Pro Pro Asp Ser
                 290                 295                 300

 gaa aag tcc att tcc att tgt gac aat tta tct gaa ctt ttg atg gca     1381
 Glu Lys Ser Ile Ser Ile Cys Asp Asn Leu Ser Glu Leu Leu Met Ala
             305                 310                 315

 atg caa gat gag ctg gac caa atg agc atg gag cac caa gaa cta ctg     1429
 Met Gln Asp Glu Leu Asp Gln Met Ser Met Glu His Gln Glu Leu Leu
         320                 325                 330

 aaa caa atg aag gaa act gaa agt cat tca gtc tgt gac gac ata gaa     1477
 Lys Gln Met Lys Glu Thr Glu Ser His Ser Val Cys Asp Asp Ile Glu
     335                 340                 345

 tgt gaa cta gag tgt tta ctc aag aaa atg gaa att aaa gga gaa caa     1525
 Cys Glu Leu Glu Cys Leu Leu Lys Lys Met Glu Ile Lys Gly Glu Gln
 350                 355                 360                 365

 atc tcc aaa ctg aag aag cat caa gac agt gtc tgt aaa ctg cag caa     1573
 Ile Ser Lys Leu Lys Lys His Gln Asp Ser Val Cys Lys Leu Gln Gln
                 370                 375                 380

 aaa gtt caa aac tca aag atg agt gaa gct tca ggt att cag caa gaa     1621
 Lys Val Gln Asn Ser Lys Met Ser Glu Ala Ser Gly Ile Gln Gln Glu
             385                 390                 395

 gac agc tac cct aaa gga tca aag aac ata aaa aat agc ccc aga aaa     1669
 Asp Ser Tyr Pro Lys Gly Ser Lys Asn Ile Lys Asn Ser Pro Arg Lys
         400                 405                 410

 tgt ttg act gac act aac ctt ttt cag aaa aac agc agc ttt cat cca     1717
 Cys Leu Thr Asp Thr Asn Leu Phe Gln Lys Asn Ser Ser Phe His Pro
     415                 420                 425

 ata cga gtt cat aat ctt caa atg aaa ttg aga aga gat gat atc atg     1765
 Ile Arg Val His Asn Leu Gln Met Lys Leu Arg Arg Asp Asp Ile Met
 430                 435                 440                 445

 tgg gaa cag taa caa aacagcaaaa ctgtcacctt aatgaacttt gtcagtgaga     1820
 Trp Glu Gln 






      <210> 299
      <211> 1506
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (293)..(1174)

      <400> 299
 ggtgcaaacc attctgttac tctttcaagc cattgaatag tttgagtcca ttgtttgaat     60

 tttagttttg aaaaagtgat aaattggcca tttgatcatc aattaatagc ggtatatatt    120

 acacctgcca ttgtttttaa atgcctaatt aaactgtcaa aacagacaca atgaaatgat    180

 agatacataa tttgagattt gatcagttgt ataaactaat tttttaaatt ttaaaattca    240

 gtttaaggtc attaagcttg tcttgtatgt ttccctcctc caggaaaaaa aa    atg     295
                                                              Met
                                                                1

 ttt att tct ttg tgg gag ttc ttc tat ggg cac ttt ttt cga ttt tgg      343
 Phe Ile Ser Leu Trp Glu Phe Phe Tyr Gly His Phe Phe Arg Phe Trp
               5                  10                  15

 atg aaa tgg cta tta cga cag atg act ggg aag tgt gaa ttg cag cga      391
 Met Lys Trp Leu Leu Arg Gln Met Thr Gly Lys Cys Glu Leu Gln Arg
          20                  25                  30

 ata ttt gat acc tat gta ggt gca caa agg aca cac agg ata gaa aat      439
 Ile Phe Asp Thr Tyr Val Gly Ala Gln Arg Thr His Arg Ile Glu Asn
      35                  40                  45

 tcc ttg aca tac tcc aag aat aag gtt tta cag aag gcg aca cat gtt      487
 Ser Leu Thr Tyr Ser Lys Asn Lys Val Leu Gln Lys Ala Thr His Val
  50                  55                  60                  65

 gtt cag agt gaa gtg gac aaa tat gta gat gat att atg aag gaa aag      535
 Val Gln Ser Glu Val Asp Lys Tyr Val Asp Asp Ile Met Lys Glu Lys
                  70                  75                  80

 aat att aac cct gag aag gat gcc agt ttt aaa ata tgc atg aag atg      583
 Asn Ile Asn Pro Glu Lys Asp Ala Ser Phe Lys Ile Cys Met Lys Met
              85                  90                  95

 tgc tta ctg cag ata act ggt tat aaa cag ctg tat ttg gat gta gaa      631
 Cys Leu Leu Gln Ile Thr Gly Tyr Lys Gln Leu Tyr Leu Asp Val Glu
         100                 105                 110

 agt gtg agg aaa agg cca tat gat tct gat aac cta cag cat gaa gag      679
 Ser Val Arg Lys Arg Pro Tyr Asp Ser Asp Asn Leu Gln His Glu Glu
     115                 120                 125

 cta ctc atg aag ctt tgg aat ctt cta atg ccc acg aag aag tta aac      727
 Leu Leu Met Lys Leu Trp Asn Leu Leu Met Pro Thr Lys Lys Leu Asn
 130                 135                 140                 145

 gct aga atc tcc aag cag tgg gct gaa att ggt ttt cag ggt gat gat      775
 Ala Arg Ile Ser Lys Gln Trp Ala Glu Ile Gly Phe Gln Gly Asp Asp
                 150                 155                 160

 ccc aag aca gac ttc aga ggc atg ggc ata ctt ggg tta atc aat ctt      823
 Pro Lys Thr Asp Phe Arg Gly Met Gly Ile Leu Gly Leu Ile Asn Leu
             165                 170                 175

 gtg tat ttc agt gaa aat tac act agt gaa gct cat cag att ctt tcc      871
 Val Tyr Phe Ser Glu Asn Tyr Thr Ser Glu Ala His Gln Ile Leu Ser
         180                 185                 190

 cgt tca aat cat cca aaa tta ggg tat tct tat gca ata gtt gga atc      919
 Arg Ser Asn His Pro Lys Leu Gly Tyr Ser Tyr Ala Ile Val Gly Ile
     195                 200                 205

 aat ctt aca gag atg gct tat agc tta ctg aag agt gaa gct ttg aag      967
 Asn Leu Thr Glu Met Ala Tyr Ser Leu Leu Lys Ser Glu Ala Leu Lys
 210                 215                 220                 225

 ttt cat ctc tat aac ctt gtt cct ggt ata cca aca atg gaa cac ttt     1015
 Phe His Leu Tyr Asn Leu Val Pro Gly Ile Pro Thr Met Glu His Phe
                 230                 235                 240

 cat cag ttt tac tgt tat ctt gtc tat gaa ttt gac aag ttt tgg ttt     1063
 His Gln Phe Tyr Cys Tyr Leu Val Tyr Glu Phe Asp Lys Phe Trp Phe
             245                 250                 255

 gaa gaa gaa cca gaa agc att atg tat ttc aat ttg tat aga gag aag     1111
 Glu Glu Glu Pro Glu Ser Ile Met Tyr Phe Asn Leu Tyr Arg Glu Lys
         260                 265                 270

 ttt cat gaa aag att aaa gga ctt tta ctg gat tgt aat gta gca ctt     1159
 Phe His Glu Lys Ile Lys Gly Leu Leu Leu Asp Cys Asn Val Ala Leu
     275                 280                 285

 act tta aaa gta taa atcatccact gtatcttcta tttctaccac attttgcaca     1214
 Thr Leu Lys Val 
 290

 ttcaacagaa tttatatgtt gtaataggaa ttatctgatc aattacactc ttatatataa   1274

 tttcctacaa aaatatttca gaaattctat ttaagaaagc tagtggacaa tcagtgtatg   1334

 tttacaattg tttatacact gttctccaaa ggtaccttat ccttccaaag atcccctctg   1394

 tagagtcatg cgaactacag tttggaactt gggacttagc ccgttggtgt aaaagtataa   1454

 atcaggtatt tgtattaaat tgattaaaat gtgtaaaatc aaaaaaaaaa aa           1506




      <210> 300
      <211> 2095
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (119)..(1159)

      <400> 300
 tttcgtggcg atgcgggggt tgacagtcat tttatttact tggattcaaa cctacaggat     60

 gatttttcag catgggttgg gagcaacagt aaaaacatat gggagttttt aaggacca      118                                                                 
 atg aaa cat tca gac tca caa gat gaa cgc agg gga cac ttg gca cca      166
 Met Lys His Ser Asp Ser Gln Asp Glu Arg Arg Gly His Leu Ala Pro
   1               5                  10                  15

 gtc tcc tcg aaa gat ttg gga cac agc ctg aca cag cct gcc agc aag      214
 Val Ser Ser Lys Asp Leu Gly His Ser Leu Thr Gln Pro Ala Ser Lys
              20                  25                  30

 ttt gat ggt gac agt gcc tac gtg ggg atg agt gac gga aac cca gag      262
 Phe Asp Gly Asp Ser Ala Tyr Val Gly Met Ser Asp Gly Asn Pro Glu
          35                  40                  45

 ctc ctg tca acc agc cag acc tac aac ggc cag agc gag aac aac gaa      310
 Leu Leu Ser Thr Ser Gln Thr Tyr Asn Gly Gln Ser Glu Asn Asn Glu
      50                  55                  60

 gac tat gag atc ccc ccg ata aca cct ccc aac ctc ccg gag cca tcc      358
 Asp Tyr Glu Ile Pro Pro Ile Thr Pro Pro Asn Leu Pro Glu Pro Ser
  65                  70                  75                  80

 ctc ctg cac ctg ggg gac cac gaa gcc agc tac cac tcg ctg tgc cac      406
 Leu Leu His Leu Gly Asp His Glu Ala Ser Tyr His Ser Leu Cys His
                  85                  90                  95

 ggc ctc acc ccc aac ggt ctg ctc cct gcc tac tcc tat cag gcc atg      454
 Gly Leu Thr Pro Asn Gly Leu Leu Pro Ala Tyr Ser Tyr Gln Ala Met
             100                 105                 110

 gac ctc cca gcc atc atg gtg tcc aac atg cta gca cag gac agc cac      502
 Asp Leu Pro Ala Ile Met Val Ser Asn Met Leu Ala Gln Asp Ser His
         115                 120                 125

 ctg ctg tcg ggc cag ctg ccc acg atc cag gag atg gtc cac tcg gaa      550
 Leu Leu Ser Gly Gln Leu Pro Thr Ile Gln Glu Met Val His Ser Glu
     130                 135                 140

 gtg gct gcc tat gac tcg ggc cgg ccc ggg ccc ctg ctg ggt cgc ccg      598
 Val Ala Ala Tyr Asp Ser Gly Arg Pro Gly Pro Leu Leu Gly Arg Pro
 145                 150                 155                 160

 gca atg ctg gcc agc cac atg agt gcc ctc agc cag tcc cag ctc atc      646
 Ala Met Leu Ala Ser His Met Ser Ala Leu Ser Gln Ser Gln Leu Ile
                 165                 170                 175

 tcg cag atg ggc atc cgg agc agc atc gcc cac agc tcc cca tca ccg      694
 Ser Gln Met Gly Ile Arg Ser Ser Ile Ala His Ser Ser Pro Ser Pro
             180                 185                 190

 ccg ggg agc aag tca gcg acc ccc tct ccc tcc agc tcc act cag gaa      742
 Pro Gly Ser Lys Ser Ala Thr Pro Ser Pro Ser Ser Ser Thr Gln Glu
         195                 200                 205

 gag gag tcg gaa gtg cat ttc aag atc tcg gga gaa aag aga cct tca      790
 Glu Glu Ser Glu Val His Phe Lys Ile Ser Gly Glu Lys Arg Pro Ser
     210                 215                 220

 gcc gac cca gga aaa aag gcc aag aac ccg aag aag aag aaa aag aag      838
 Ala Asp Pro Gly Lys Lys Ala Lys Asn Pro Lys Lys Lys Lys Lys Lys
 225                 230                 235                 240

 gac ccc aat gag ccg cag aag cct gtg tcg gcc tac gca ctc ttc ttc      886
 Asp Pro Asn Glu Pro Gln Lys Pro Val Ser Ala Tyr Ala Leu Phe Phe
                 245                 250                 255

 aga gac act cag gcc gcc atc aag ggt cag aac ccc agt gcc act ttc      934
 Arg Asp Thr Gln Ala Ala Ile Lys Gly Gln Asn Pro Ser Ala Thr Phe
             260                 265                 270

 ggt gac gtg tcc aaa atc gtg gcc tcc atg tgg gac agc ctg gga gag      982
 Gly Asp Val Ser Lys Ile Val Ala Ser Met Trp Asp Ser Leu Gly Glu
         275                 280                 285

 gaa cag aag cag gac ttc ccg cac atc tct gag ttc ccc agc agc tcg     1030
 Glu Gln Lys Gln Asp Phe Pro His Ile Ser Glu Phe Pro Ser Ser Ser
     290                 295                 300

 gga tcc tgc tca cct ggc cca tcc aac ccc acc agc agc ggg gac tgg     1078
 Gly Ser Cys Ser Pro Gly Pro Ser Asn Pro Thr Ser Ser Gly Asp Trp
 305                 310                 315                 320

 gac agc agc tac ccc agt ggg gag tgt ggc atc agc acc tgc agc ctg     1126
 Asp Ser Ser Tyr Pro Ser Gly Glu Cys Gly Ile Ser Thr Cys Ser Leu
                 325                 330                 335

 ctc ccc agg gac aaa tcg ctc tac ctc acc taa tcccgcct ccctaccatc     1177
 Leu Pro Arg Asp Lys Ser Leu Tyr Leu Thr 
             340                 345

 cctgaggctc gctggaaggc actgctcaga gcctgaaggg ctgacagcag aaaagaggcc   1237

 ctggccagag gcagggtggc ccatcggaga gagcagtgac acacccattg cccgggggct   1297

 gagtctcttc ctcaacctcc caccagactc tgcagaggca gcccactgcc caccaccagc   1357

 ccaaagaacc tgcaggaacc ttccgcccgc tgacctgctt gctccagggt aactgtggac   1417

 cctgtcctcg ccctgcgcac ggtaccctat gtctggacac ccggccccag ctccagcccc   1477

 agcccaggtg ggccgcccct ggcggggtcg cttaccaacg gacacccacc ccagatgcat   1537

 gggccagagg gccggccccc ggcatagatg tgcacatcgg ttttccagtg tgaacaaaag   1597

 attacgaaac ctagaaactg ttggttccgt gtaagtagtt gactacgtgt tttagaactg   1657

 tgctgaagac atctgtaaga ctattttgtg ggggaaaaaa gtagtttcct ttaaggtaaa   1717

 aagcatttta tatgatcctt agcacatttt taagttttat cttaagggag acgcgcacaa   1777

 aagcggctgc caaaccgttt cgtcatcctc acagcaagga ccggacgctt gctagccacc   1837

 ccggagcact gctctccttt taatcatgta ttcatctatt ttaaattgcc ggcgacgact   1897

 tttgtctatt tatgaagaaa ccttgagaac gaagttacag cttatcctac cgtgtgtgtg   1957

 gttttggggt ttcgtttggg tttgggttct tgacgtcgtt tgcagctgtt tcctggccct   2017

 ggcgagtgtc tgtcttggtg cccagtgctt ctctcaaatc tctttataat aaaacttctg   2077

 aaaagctgaa aaaaaaaa                                                 2095




      <210> 301
      <211> 5900
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (26)..(3163)

      <400> 301
 cttcccgggt cgacgatttc gtggc  atg atg aca cag gga agg gca gag aca      52
                              Met Met Thr Gln Gly Arg Ala Glu Thr
                                1               5

 cag cta gaa aca aca cag gca ggt gag aag ata cag gaa gac agg aag      100
 Gln Leu Glu Thr Thr Gln Ala Gly Glu Lys Ile Gln Glu Asp Arg Lys
  10                  15                  20                  25

 gcc cag gca gat aag ggc aca cag gaa gac aga agg atg cag gga gag      148
 Ala Gln Ala Asp Lys Gly Thr Gln Glu Asp Arg Arg Met Gln Gly Glu
                  30                  35                  40

 aag ggg atg cag gga gag aag ggg acg cag tca gag ggg agc gcg ccc      196
 Lys Gly Met Gln Gly Glu Lys Gly Thr Gln Ser Glu Gly Ser Ala Pro
              45                  50                  55

 aca gcc atg gaa ggt cag tct gag caa gag gtg gta acc agc ctc ggc      244
 Thr Ala Met Glu Gly Gln Ser Glu Gln Glu Val Val Thr Ser Leu Gly
          60                  65                  70

 cca cca tcc aga acc ccc aaa ctc cca cct aca gcg ggt cct aga gct      292
 Pro Pro Ser Arg Thr Pro Lys Leu Pro Pro Thr Ala Gly Pro Arg Ala
      75                  80                  85

 cct ctg aat att gaa tgt ttt gta cag acc cca gaa ggg tct tgt ttc      340
 Pro Leu Asn Ile Glu Cys Phe Val Gln Thr Pro Glu Gly Ser Cys Phe
  90                  95                 100                 105

 cca aaa aaa cct ggt tgc ctg ccc aga tct gag gag gca gta gta aca      388
 Pro Lys Lys Pro Gly Cys Leu Pro Arg Ser Glu Glu Ala Val Val Thr
                 110                 115                 120

 gcc tcc agg aac cat gag caa act gtg ctg ggt ccc ctg tca ggg aac      436
 Ala Ser Arg Asn His Glu Gln Thr Val Leu Gly Pro Leu Ser Gly Asn
             125                 130                 135

 ctc atg ctc cca gca cag ccg ccc cat gag ggg agt gtg gag cag gtg      484
 Leu Met Leu Pro Ala Gln Pro Pro His Glu Gly Ser Val Glu Gln Val
         140                 145                 150

 gga gga gag aga tgc cga ggg cca cag tca tca ggc cca gtc gag gcc      532
 Gly Gly Glu Arg Cys Arg Gly Pro Gln Ser Ser Gly Pro Val Glu Ala
     155                 160                 165

 aag cag gag gac agc ccg ttc cag tgc ccc aag gag gag cgg cca ggg      580
 Lys Gln Glu Asp Ser Pro Phe Gln Cys Pro Lys Glu Glu Arg Pro Gly
 170                 175                 180                 185

 gga gtg ccg tgt atg gat cag ggt ggc tgt cct cta gct ggc ctg agc      628
 Gly Val Pro Cys Met Asp Gln Gly Gly Cys Pro Leu Ala Gly Leu Ser
                 190                 195                 200

 cag gag gta ccc acg atg cct tct ctt cct gga act ggg ctg aca gct      676
 Gln Glu Val Pro Thr Met Pro Ser Leu Pro Gly Thr Gly Leu Thr Ala
             205                 210                 215

 agc cca aag gcg ggg ccg tgt agc acc ccg act tct cag cac ggg agc      724
 Ser Pro Lys Ala Gly Pro Cys Ser Thr Pro Thr Ser Gln His Gly Ser
         220                 225                 230

 aca gcc acc ttc ctg ccc tct gag gat cag gtc ctg atg agt tct gcc      772
 Thr Ala Thr Phe Leu Pro Ser Glu Asp Gln Val Leu Met Ser Ser Ala
     235                 240                 245

 cca aca ctg cac ctg ggg ctg ggg acc ccc act cag agt cac cca cca      820
 Pro Thr Leu His Leu Gly Leu Gly Thr Pro Thr Gln Ser His Pro Pro
 250                 255                 260                 265

 gaa acc atg gcc acc agc agt gag ggg gcc tgc gcc cag gta cca gat      868
 Glu Thr Met Ala Thr Ser Ser Glu Gly Ala Cys Ala Gln Val Pro Asp
                 270                 275                 280

 gtg gag ggg cgg acc cca ggt ccc cgg agc tgt gac cct ggc ctc ata      916
 Val Glu Gly Arg Thr Pro Gly Pro Arg Ser Cys Asp Pro Gly Leu Ile
             285                 290                 295

 gat tcc ctg aag aac tac ctg ctt ctg ctg ctg aag ctg tcc agc aca      964
 Asp Ser Leu Lys Asn Tyr Leu Leu Leu Leu Leu Lys Leu Ser Ser Thr
         300                 305                 310

 gag aca agt gga gca ggg gga gag tcc cag gtg ggg gca gcc acc gga     1012
 Glu Thr Ser Gly Ala Gly Gly Glu Ser Gln Val Gly Ala Ala Thr Gly
     315                 320                 325

 ggt ctg gtg ccc tca gcc act ctg aca ccc act gtg gaa gtg gct ggg     1060
 Gly Leu Val Pro Ser Ala Thr Leu Thr Pro Thr Val Glu Val Ala Gly
 330                 335                 340                 345

 ctt agt ccc cgg aca tcg agg cgc atc ctg gag cgt gtg gag aac aac     1108
 Leu Ser Pro Arg Thr Ser Arg Arg Ile Leu Glu Arg Val Glu Asn Asn
                 350                 355                 360

 cac ctg gtg cag agt gca cag acc ctg ctg ctg agc ccc tgt acc tcc     1156
 His Leu Val Gln Ser Ala Gln Thr Leu Leu Leu Ser Pro Cys Thr Ser
             365                 370                 375

 cgc cgc ctc acc ggc ctc ctg gac cgt gag gtg cag gct ggc cgc cag     1204
 Arg Arg Leu Thr Gly Leu Leu Asp Arg Glu Val Gln Ala Gly Arg Gln
         380                 385                 390

 gcc ctt gct gct gcc cga ggc tcc tgg ggt cct ggt ccc agc tcc ctc     1252
 Ala Leu Ala Ala Ala Arg Gly Ser Trp Gly Pro Gly Pro Ser Ser Leu
     395                 400                 405

 act gtc cct gcc att gtg gta gac gag gag gac cct ggg ctg gcc tca     1300
 Thr Val Pro Ala Ile Val Val Asp Glu Glu Asp Pro Gly Leu Ala Ser
 410                 415                 420                 425

 gaa gga gcc agt gag ggt gaa gga gag gtt tcc ctt gag ggg cct ggc     1348
 Glu Gly Ala Ser Glu Gly Glu Gly Glu Val Ser Leu Glu Gly Pro Gly
                 430                 435                 440

 ctc ctg ggg gcc tct cag gag agc agc atg gct ggt cga ctg ggg gag     1396
 Leu Leu Gly Ala Ser Gln Glu Ser Ser Met Ala Gly Arg Leu Gly Glu
             445                 450                 455

 gcg ggt ggg cag gca gcc cct gga cag ggg ccc tca gca gag agc ata     1444
 Ala Gly Gly Gln Ala Ala Pro Gly Gln Gly Pro Ser Ala Glu Ser Ile
         460                 465                 470

 gcc cag gag ccc tcc caa gag gag aag ttc cca ggg gag gct ctg aca     1492
 Ala Gln Glu Pro Ser Gln Glu Glu Lys Phe Pro Gly Glu Ala Leu Thr
     475                 480                 485

 ggc ctc ccg gca gct aca cct gag gaa ctg gct cta ggg gcc cgg agg     1540
 Gly Leu Pro Ala Ala Thr Pro Glu Glu Leu Ala Leu Gly Ala Arg Arg
 490                 495                 500                 505

 aag aga ttt ctc cct aag gtc aga gca gca gga gac ggg gag gca acc     1588
 Lys Arg Phe Leu Pro Lys Val Arg Ala Ala Gly Asp Gly Glu Ala Thr
                 510                 515                 520

 aca cct gaa gaa agg gag agc ccc acg gtt tcc ccc cgg ggg ccc agg     1636
 Thr Pro Glu Glu Arg Glu Ser Pro Thr Val Ser Pro Arg Gly Pro Arg
             525                 530                 535

 aaa agc ctg gtg cct ggg tcc cca ggg act cca ggg cgg gag aga cgc     1684
 Lys Ser Leu Val Pro Gly Ser Pro Gly Thr Pro Gly Arg Glu Arg Arg
         540                 545                 550

 tcc cct acg cag ggc aga aag gcg agc atg ctg gag gtg cct cgg gca     1732
 Ser Pro Thr Gln Gly Arg Lys Ala Ser Met Leu Glu Val Pro Arg Ala
     555                 560                 565

 gag gag gag ctg gcg gca gga gac ctg ggc ccc agc ccc aag gcc ggc     1780
 Glu Glu Glu Leu Ala Ala Gly Asp Leu Gly Pro Ser Pro Lys Ala Gly
 570                 575                 580                 585

 ggt ctg gac aca gag gtg gcc ctg gat gaa ggc aag cag gag aca ctg     1828
 Gly Leu Asp Thr Glu Val Ala Leu Asp Glu Gly Lys Gln Glu Thr Leu
                 590                 595                 600

 gcc aag ccc agg aaa gcc aaa gac ctg ctg aaa gcc cca cag gtg atc     1876
 Ala Lys Pro Arg Lys Ala Lys Asp Leu Leu Lys Ala Pro Gln Val Ile
             605                 610                 615

 cgg aag att cgg gtg gag cag ttt cct gat gcc tcc ggt agc ctg aag     1924
 Arg Lys Ile Arg Val Glu Gln Phe Pro Asp Ala Ser Gly Ser Leu Lys
         620                 625                 630

 ctg tgg tgc cag ttt ttc aac att ctt agt gac tca gtc ttg aca tgg     1972
 Leu Trp Cys Gln Phe Phe Asn Ile Leu Ser Asp Ser Val Leu Thr Trp
     635                 640                 645

 gcc aag gat cag cgc cca gtg ggc gag gtg ggc agg agc gca ggg gat     2020
 Ala Lys Asp Gln Arg Pro Val Gly Glu Val Gly Arg Ser Ala Gly Asp
 650                 655                 660                 665

 gag ggg ccg gcg gcc ttg gcc atc gtg cag gcc tcc ccc gta gac tgc     2068
 Glu Gly Pro Ala Ala Leu Ala Ile Val Gln Ala Ser Pro Val Asp Cys
                 670                 675                 680

 ggt gtg tat cgg tgc acc atc cac aat gag cac ggc tcg gcc tcc acc     2116
 Gly Val Tyr Arg Cys Thr Ile His Asn Glu His Gly Ser Ala Ser Thr
             685                 690                 695

 gac ttc tgc ctc agc cct gag gtg ttg tca gga ttc atc tcc aga gaa     2164
 Asp Phe Cys Leu Ser Pro Glu Val Leu Ser Gly Phe Ile Ser Arg Glu
         700                 705                 710

 gaa ggt gaa gtt gga gaa gag att gag atg acc cct atg gtg ttt gct     2212
 Glu Gly Glu Val Gly Glu Glu Ile Glu Met Thr Pro Met Val Phe Ala
     715                 720                 725

 aag ggt ctg gct gac tct ggc tgc tgg ggg gac aag ctc ttt ggg cga     2260
 Lys Gly Leu Ala Asp Ser Gly Cys Trp Gly Asp Lys Leu Phe Gly Arg
 730                 735                 740                 745

 ctg gta agc gag gag ctc cga ggg ggt gga tat ggg tgt ggc ctt cgg     2308
 Leu Val Ser Glu Glu Leu Arg Gly Gly Gly Tyr Gly Cys Gly Leu Arg
                 750                 755                 760

 aag gcc tcc cag gcc aag gtc atc tac ggg ctg gaa ccc atc ttc gag     2356
 Lys Ala Ser Gln Ala Lys Val Ile Tyr Gly Leu Glu Pro Ile Phe Glu
             765                 770                 775

 tcg ggc cgc acg tgc atc atc aag gtg tcc agc ctg ctt gtg ttt ggg     2404
 Ser Gly Arg Thr Cys Ile Ile Lys Val Ser Ser Leu Leu Val Phe Gly
         780                 785                 790

 ccc agc agt gag act tct ctt gtg ggc aga aac tac gac gtc acc atc     2452
 Pro Ser Ser Glu Thr Ser Leu Val Gly Arg Asn Tyr Asp Val Thr Ile
     795                 800                 805

 cag ggg tgc aag atc cag aac atg agt cgg gag tac tgc aaa atc ttc     2500
 Gln Gly Cys Lys Ile Gln Asn Met Ser Arg Glu Tyr Cys Lys Ile Phe
 810                 815                 820                 825

 gca gca gaa gcc cgg gcc gcg cct ggc ttt ggg gag gtg cct gag atc     2548
 Ala Ala Glu Ala Arg Ala Ala Pro Gly Phe Gly Glu Val Pro Glu Ile
                 830                 835                 840

 atc cca ctg tat ctg atc tac cgg cct gca aac aat atc cca tat gct     2596
 Ile Pro Leu Tyr Leu Ile Tyr Arg Pro Ala Asn Asn Ile Pro Tyr Ala
             845                 850                 855

 acc ctg gag gaa gac ctg ggc aag ccc ctg gag tct tac tgt tct cgg     2644
 Thr Leu Glu Glu Asp Leu Gly Lys Pro Leu Glu Ser Tyr Cys Ser Arg
         860                 865                 870

 gaa tgg ggc tgt gct gag gct ccg aca gca tct ggc agc tct gag gcc     2692
 Glu Trp Gly Cys Ala Glu Ala Pro Thr Ala Ser Gly Ser Ser Glu Ala
     875                 880                 885

 atg cag aaa tgc cag acc ttc caa cac tgg ctg tat cag tgg aca aat     2740
 Met Gln Lys Cys Gln Thr Phe Gln His Trp Leu Tyr Gln Trp Thr Asn
 890                 895                 900                 905

 ggc agc ttc ctt gtc aca gac ttg gca ggg gtt gac tgg aag atg act     2788
 Gly Ser Phe Leu Val Thr Asp Leu Ala Gly Val Asp Trp Lys Met Thr
                 910                 915                 920

 gat gtg cag att gct acc aaa ctc cga gga tac cag ggc ctc aag gaa     2836
 Asp Val Gln Ile Ala Thr Lys Leu Arg Gly Tyr Gln Gly Leu Lys Glu
             925                 930                 935

 agc tgc ttc cct gcc ctg ctg gac cgg ttc gcc tcc tcc cac cag tgc     2884
 Ser Cys Phe Pro Ala Leu Leu Asp Arg Phe Ala Ser Ser His Gln Cys
         940                 945                 950

 aat gcc tac tgt gag ctg ctg ggg ctg aca cct ctc aag ggc ccg gag     2932
 Asn Ala Tyr Cys Glu Leu Leu Gly Leu Thr Pro Leu Lys Gly Pro Glu
     955                 960                 965

 gcg gcc cac ccc caa gcc aaa gcc aaa ggc tct aag agt cca tct gct     2980
 Ala Ala His Pro Gln Ala Lys Ala Lys Gly Ser Lys Ser Pro Ser Ala
 970                 975                 980                 985

 ggc agg aaa ggc tcc cag ctg agt cct cag ccc cag aag aaa ggc ctc     3028
 Gly Arg Lys Gly Ser Gln Leu Ser Pro Gln Pro Gln Lys Lys Gly Leu
                 990                 995                1000

 cct agt cct cag ggc acc cgg aag agt gct cca agt tcc aag gcc acc     3076
 Pro Ser Pro Gln Gly Thr Arg Lys Ser Ala Pro Ser Ser Lys Ala Thr
            1005                1010                1015

 cct cag gcc tca gag cca gtc acc act cag ttg ttg gga cag cct ccc     3124
 Pro Gln Ala Ser Glu Pro Val Thr Thr Gln Leu Leu Gly Gln Pro Pro
        1020                1025                1030

 acc caa gag gag ggc tcc aag gcc cag ggc atg cgg tag cctccgcaga      3173
 Thr Gln Glu Glu Gly Ser Lys Ala Gln Gly Met Arg 
    1035                1040                1045

 ggctgggggc ctccacccag cagcagacca accaggaagc agcttgaact ggatggagac   3233

 tttccaaata tggaactaac tggagaaggt gcacgaagga gacaccactt ggggacctct   3293

 ctgagcaggc tctcgtgaat caactcgtca tcagatggct ttggtgcatg gcacatagcc   3353

 cactggcctc ttctggtgcc actgtcaccc agggctcccg ggcctcaagc agtccccacc   3413

 tccgagtgcc tggcaaccta ggccctcctt gaagtttaca ctttgccact gctggaggct   3473

 cccctgagtc ctctgcatga gttctgcacc ccaagccctt gccccagccc agtccagcag   3533

 cagatgttac aatctgagtg aggacatgca ggccaacttt taccctcctg catttgcctg   3593

 gccctgatct cgcctgtact cagggatcca gacttcctct gctggtctgg cctggtgact   3653

 ctcagggtat cttctccttc cagctacttt cgctcactga tctcagctta tcctgcaact   3713

 aaccatcctt gagcccagat ggggctcagg gcccttccag agcctgtcat gtccttgtgc   3773

 agtggccttt gatgtgtgtt cacgctcttc ccccttcact cactcgcctg cttcccatgc   3833

 tcccttgtac cccctcgcca catccctgtc ttggggccca gctgcagcct gctgcctgcc   3893

 cttcatggct ctgcacatgg ccctttgctt gagggctccc cactccctgc ccaccaatac   3953

 ccaggtgagg aacagaccct ctggcctctc accccacttc agtgctctct tccccaactt   4013

 ctctcgggct ctttgctcat gaggtgagag ctggtgtgag ggttgtgtca gcagctgtag   4073

 ccagagagag gtgttgactc tgagagacct tgcactccat actgaaagga ggtggggtca   4133

 cagtgaattt cacatcccct ctcaaccagg agtggagggc taggtccctt ccccatgggg   4193

 agtacacttg ggtgttctag gagggatgca gtctatccat gcacttgggt ggaggggagt   4253

 ctctgtgcct gggaattagg acccctgctc caaccatcgc tcttgatcct ggggccccag   4313

 ctctgggtcc tcatgtatgg gctcccaagg acccagcagc ctggatcctt ccagagcatc   4373

 cctcctggag gcctgggatg gggtaggtct gcagctagcc tactcccttt ggaatgcaat   4433

 aaaggcagca ttgtgtgccc tgcttgccct catctggtgt ggttggaggt ctgtggagtc   4493

 aaggtccccc tctcccaggc aggctctctg agggcattct gtagtcccag gcccactgga   4553

 aaaatgaatc tatattttgg ttcctggacc gaagttcagt cgcagccttc tgtggccaca   4613

 gaaagacagc ttgtgctgct tgcacaactg agctgctggt gtgtacccct tagcagggtg   4673

 tctggggact tacgcctttg gaattgctct tcattcagaa gaggaacaca aaggaagcca   4733

 cccaggaagg aagcacagag ctgggggctc tggaaacgcc ctgtgtctct ggctacagca   4793

 agaccagccc aggagcccac cagcacctgc ctctcagcta cttgctgacc atttcctgct   4853

 tctcaagctg cagagaagct tttcattccc acccccaccc ggaacctccc cttgcctaac   4913

 atttcccctc tatggtaaca tctctgactt ctctacctcc tctgtgctca ggtgactcca   4973

 catcttctgc cccagtgtgt ccccacctct cccagcctgt atacccagat tactttggtg   5033

 aactgagagc tggagtactg ttcattcatt tattcattca cccactcatt cagcagacct   5093

 tggcattttc acatgattta tctcccactc tgattcacat atgtttgacc aaggcactgg   5153

 gcagctgcca atttcccgtc ccttctgtag tcccagatga atggatacag acctctttgg   5213

 ggaaggctgc aaggaaggtt cacaacatgc atctaagtgt taaaataagt ttttccttca   5273

 aaaatacatt tgacttcctc tccatttaag gtctggaaat caagtgggag atcttgactt   5333

 taccttggca cttgagacag aactgttggc ccagaagtct ttagttaagg tcattactag   5393

 gccatatctt aggggcgtct ggcctttttc attcctggga cccacagctc gaggtctggt   5453

 ttccatgccc tatcccttac gatgagcgcc ctattttgtt ccttctgtct atctctgttg   5513

 ctgagatcag ggagcccacg ttcacagcag ctctttcaag cagcctccca ggcctagaga   5573

 ggaaaatcag cagagcctcg tgaatgtatt tctcgtggca agaagggagc tcatcttctg   5633

 ggtcctgcca gagggcagtg agggggttga tgggctgggt gcatgccagg gacccaatca   5693

 agcattttta tcttctgaaa tctttgaatt cctgcctttc ttggatgttt ggtcttttga   5753

 tataatttag catgggccaa catttggtcc agatttgtat tagccaagcc ctcctaaaat   5813

 agtaataaca gtatctggcg atttgagctt ttacgtagaa tgtagaatct ctggtgagtg   5873

 aacatatcaa taaagacaac ctgaacc                                       5900




      <210> 302
      <211> 872
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (162)..(521)

      <400> 302
 tttcgtgcgt aggaggggtc ggaggtctta cccaacagat tgacgcggcg ttagtattgg     60

 ccgtgtaccc gaaaaactga ttgactgggc tggcgttaac tgtgcggagg caggatttcc    120

 ctggggaaag tcttcactca gagcttcgct gacagccaag g    atg gca agc aag     173
                                                  Met Ala Ser Lys
                                                    1

 ggg ccc tcg gcc tct gca tct cct gag aac tcc agt gca ggg ggg ccc      221
 Gly Pro Ser Ala Ser Ala Ser Pro Glu Asn Ser Ser Ala Gly Gly Pro
   5                  10                  15                  20

 agt ggg agc agc aat ggc gct ggc gag agc gga ggg cag gac agc act      269
 Ser Gly Ser Ser Asn Gly Ala Gly Glu Ser Gly Gly Gln Asp Ser Thr
                  25                  30                  35

 ttc gag tgc aac atc tgc ttg gac aca gcc aag gat gcc gtc atc agc      317
 Phe Glu Cys Asn Ile Cys Leu Asp Thr Ala Lys Asp Ala Val Ile Ser
              40                  45                  50

 ctg tgt ggc cac ctc ttc tgt tgg ccg tgt tta cat cag tgg ttg gag      365
 Leu Cys Gly His Leu Phe Cys Trp Pro Cys Leu His Gln Trp Leu Glu
          55                  60                  65

 acc aga cct aac aga cag gtg tgt cct gtt tgc aaa gct ggc atc agc      413
 Thr Arg Pro Asn Arg Gln Val Cys Pro Val Cys Lys Ala Gly Ile Ser
      70                  75                  80

 cga gac aag gtc atc ccc ctc tat gga agg ggc agc act ggg caa cag      461
 Arg Asp Lys Val Ile Pro Leu Tyr Gly Arg Gly Ser Thr Gly Gln Gln
  85                  90                  95                 100

 gac ccc aga gag aag acc ccg tcc tcg tcc tca agg aca gag gcc aga      509
 Asp Pro Arg Glu Lys Thr Pro Ser Ser Ser Ser Arg Thr Glu Ala Arg
                 105                 110                 115

 gcc gga gaa tag agg gggatttcaa ggatgtggct ttggagatgg tggcttccag      564
 Ala Gly Glu 


 atgtcttgtg aagtcggggc atttccctgt ggatattgtg ccacagcatt tactctccct    624

 tgactgggcg gtcgtcctcc agtctgtccc ctgggaccac ccccagtatt gtgggaccga    684

 ggcagtccct gtcacggcct cgttcctaat tttggtggcc tgggcggagt ccattggtac    744

 tgggtccctg gttgccttaa gggtggcgcc ctggctacat tcgtgggcag ggtcttggca    804

 ggggcgtgca cccccaactc ccggtggttg ggcgcctggg acacttggtc cgggcacccg    864

 ggtttgcc                                                             872




      <210> 303
      <211> 7861
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (458)..(6442)

      <400> 303
 atcagacagg caaaggccca gagaaagcag cttcatgact ttgtggccag gggcacagtc     60

 ctttcttact gtgaaacttt actagaaccc gaatgttctt caagggttgc tggcaggcct    120

 cagtgtaaac aaatagacca gtcatcatca gaccagacca ggaatgaggg tgaagcaccg    180

 ggatttcatg tggcatctct atctgctgaa gcagggcaga tagatctgtt acctgatgag    240

 aggaaagtcc aggccacatc tctgtctgca gacagctttg aatctctgcc caatacggaa    300

 actgacagag agccatggga tcctgtgcag gctttctccc atgctgctcc tgctcaagac    360

 aggaaacgtc gtactggaga actgaggcag ttcgcgggag caagtgaacc atttatatgt    420

 cactctagtt cttctgaaat catagagaaa aaaaaag atg caa cca gaa cac ctt     475
                                          Met Gln Pro Glu His Leu
                                            1               5

 cct cag ctg atc ctt tgg ccc cag aca gtc ctc gtt ctt cag cac ctg      523
 Pro Gln Leu Ile Leu Trp Pro Gln Thr Val Leu Val Leu Gln His Leu
              10                  15                  20

 tgg agg gag gtc agg agg gta gta tca aag aag gta gtg gct gcc tta      571
 Trp Arg Glu Val Arg Arg Val Val Ser Lys Lys Val Val Ala Ala Leu
          25                  30                  35

 cct tct cag gcc cct tat gat gat cct aga gtg act ctg cat gag cta      619
 Pro Ser Gln Ala Pro Tyr Asp Asp Pro Arg Val Thr Leu His Glu Leu
      40                  45                  50

 agt cag tca gtt ccg cag gag act gca gag ggc ata ccc cct ggc agt      667
 Ser Gln Ser Val Pro Gln Glu Thr Ala Glu Gly Ile Pro Pro Gly Ser
  55                  60                  65                  70

 cag gac agc agc cca gag cat cag gaa ccc aga act cta gac acc aca      715
 Gln Asp Ser Ser Pro Glu His Gln Glu Pro Arg Thr Leu Asp Thr Thr
                  75                  80                  85

 tat gga gaa gtt tca gat aat ttg tta gtg act gca cag gga gaa aaa      763
 Tyr Gly Glu Val Ser Asp Asn Leu Leu Val Thr Ala Gln Gly Glu Lys
              90                  95                 100

 aca gcc cat ttt gaa agt cag tct gtg acc tgt gat gtt cag aat tct      811
 Thr Ala His Phe Glu Ser Gln Ser Val Thr Cys Asp Val Gln Asn Ser
         105                 110                 115

 aca agt gcc tca ggg cct aag caa gac cat gtc caa tgc cct gag gct      859
 Thr Ser Ala Ser Gly Pro Lys Gln Asp His Val Gln Cys Pro Glu Ala
     120                 125                 130

 tct act ggc ttt gaa gaa ggt agg gca agt ccc aaa caa gat acc att      907
 Ser Thr Gly Phe Glu Glu Gly Arg Ala Ser Pro Lys Gln Asp Thr Ile
 135                 140                 145                 150

 ctg cct gga gct ctg aca agg gtt gca ctg gaa gct ccc aca cag cag      955
 Leu Pro Gly Ala Leu Thr Arg Val Ala Leu Glu Ala Pro Thr Gln Gln
                 155                 160                 165

 tgt gtg cag tgt aag gag agt gtt ggg tct ggg ttg aca gaa gtc tgc     1003
 Cys Val Gln Cys Lys Glu Ser Val Gly Ser Gly Leu Thr Glu Val Cys
             170                 175                 180

 agg gct ggc agc aaa cat tcc agg cca att cca ctg cca gat caa aga     1051
 Arg Ala Gly Ser Lys His Ser Arg Pro Ile Pro Leu Pro Asp Gln Arg
         185                 190                 195

 cca agc gca aat cct ggg gga att ggg gag gaa gcc cca tgt aga cac     1099
 Pro Ser Ala Asn Pro Gly Gly Ile Gly Glu Glu Ala Pro Cys Arg His
     200                 205                 210

 cca agg gaa gct tta gat ggc cct gtc ttc tca agg aac cct gaa ggc     1147
 Pro Arg Glu Ala Leu Asp Gly Pro Val Phe Ser Arg Asn Pro Glu Gly
 215                 220                 225                 230

 agc agg act ctc agc ccg tct aga ggg aaa gag agc aga act ctt cct     1195
 Ser Arg Thr Leu Ser Pro Ser Arg Gly Lys Glu Ser Arg Thr Leu Pro
                 235                 240                 245

 tgc cga cag cca tgc agt tct caa cct gtt gct act cat gct tat tcc     1243
 Cys Arg Gln Pro Cys Ser Ser Gln Pro Val Ala Thr His Ala Tyr Ser
             250                 255                 260

 tcc cat tcc tct act tta ctg tgt ttt aga gat ggt gac cta ggg aag     1291
 Ser His Ser Ser Thr Leu Leu Cys Phe Arg Asp Gly Asp Leu Gly Lys
         265                 270                 275

 gag cct ttc aag gct gcc cca cat act atc cac cca ccc tgt gta gta     1339
 Glu Pro Phe Lys Ala Ala Pro His Thr Ile His Pro Pro Cys Val Val
     280                 285                 290

 cct tcc agg gcc tat gaa atg gat gag aca gga gag atc tct agg gga     1387
 Pro Ser Arg Ala Tyr Glu Met Asp Glu Thr Gly Glu Ile Ser Arg Gly
 295                 300                 305                 310

 cct gat gtg cac ttg aca cat ggc ctt gag ccc aaa gat gtt aac agg     1435
 Pro Asp Val His Leu Thr His Gly Leu Glu Pro Lys Asp Val Asn Arg
                 315                 320                 325

 gaa ttt agg cta aca gag agc agc act tgt gag cct tct act gtg gct     1483
 Glu Phe Arg Leu Thr Glu Ser Ser Thr Cys Glu Pro Ser Thr Val Ala
             330                 335                 340

 gct gtc cta tct cga gct caa ggc tgc aga tcc cct tct gct cct gac     1531
 Ala Val Leu Ser Arg Ala Gln Gly Cys Arg Ser Pro Ser Ala Pro Asp
         345                 350                 355

 gtg agg aca ggt tcc ttc agc cac tca gct act gat gga agc gtg ggg     1579
 Val Arg Thr Gly Ser Phe Ser His Ser Ala Thr Asp Gly Ser Val Gly
     360                 365                 370

 tta ata ggg gtt cct gag aaa aag gtt gct gag aag caa gca agc aca     1627
 Leu Ile Gly Val Pro Glu Lys Lys Val Ala Glu Lys Gln Ala Ser Thr
 375                 380                 385                 390

 gaa ctt gag gct gcc tct ttc cct gca ggc atg tac tct gag ccc ctg     1675
 Glu Leu Glu Ala Ala Ser Phe Pro Ala Gly Met Tyr Ser Glu Pro Leu
                 395                 400                 405

 agg cag ttt agg gac agc tct gta ggt gac cag aat gca cag gtg tgt     1723
 Arg Gln Phe Arg Asp Ser Ser Val Gly Asp Gln Asn Ala Gln Val Cys
             410                 415                 420

 caa acc aat cca gaa cca cct gca aca act cag gga cca cac acc ctg     1771
 Gln Thr Asn Pro Glu Pro Pro Ala Thr Thr Gln Gly Pro His Thr Leu
         425                 430                 435

 gat tta agt gaa ggg tct gct ggg agc aag ttg gtg gta gag cca cag     1819
 Asp Leu Ser Glu Gly Ser Ala Gly Ser Lys Leu Val Val Glu Pro Gln
     440                 445                 450

 cat gaa tgt tta gaa aat acc act aga tgt ttt ttg gaa aag cca caa     1867
 His Glu Cys Leu Glu Asn Thr Thr Arg Cys Phe Leu Glu Lys Pro Gln
 455                 460                 465                 470

 ttt tcc act gag ttg agg gat cac aat cgc ttg gat tcc caa gcc aag     1915
 Phe Ser Thr Glu Leu Arg Asp His Asn Arg Leu Asp Ser Gln Ala Lys
                 475                 480                 485

 ttt gta gca agg tta aaa cat acc tgc agc ccc cag gaa gac agt ccc     1963
 Phe Val Ala Arg Leu Lys His Thr Cys Ser Pro Gln Glu Asp Ser Pro
             490                 495                 500

 tgg cag gaa gaa gag cag cac aga gac cag gct tca ggt ggt gga gaa     2011
 Trp Gln Glu Glu Glu Gln His Arg Asp Gln Ala Ser Gly Gly Gly Glu
         505                 510                 515

 ggc ttc gcc cag ggt gtg aat ccc ctt cct gat gaa gat ggc tta gat     2059
 Gly Phe Ala Gln Gly Val Asn Pro Leu Pro Asp Glu Asp Gly Leu Asp
     520                 525                 530

 ggc tgt cag att tta gat gct ggg aga gag gag gtg gct gtg gcc aag     2107
 Gly Cys Gln Ile Leu Asp Ala Gly Arg Glu Glu Val Ala Val Ala Lys
 535                 540                 545                 550

 cct cct gtg tcc aag att tta tca cag ggc ttc aaa gac cca gcc act     2155
 Pro Pro Val Ser Lys Ile Leu Ser Gln Gly Phe Lys Asp Pro Ala Thr
                 555                 560                 565

 gtg tcc ttg agg caa aat gaa aca ccg cag cct gct gct cag agg agt     2203
 Val Ser Leu Arg Gln Asn Glu Thr Pro Gln Pro Ala Ala Gln Arg Ser
             570                 575                 580

 ggc cac ctc tac act ggc aga gag cag cca gca ccc aac cac agg ggc     2251
 Gly His Leu Tyr Thr Gly Arg Glu Gln Pro Ala Pro Asn His Arg Gly
         585                 590                 595

 tca ctt cct gtg act aca atc ttc tct ggc ccc aaa cac tcc agg tcc     2299
 Ser Leu Pro Val Thr Thr Ile Phe Ser Gly Pro Lys His Ser Arg Ser
     600                 605                 610

 tcc ccc aca cca cag ttc tca gtt gtc ggc tct tct cgt tct ctt cag     2347
 Ser Pro Thr Pro Gln Phe Ser Val Val Gly Ser Ser Arg Ser Leu Gln
 615                 620                 625                 630

 gag ctg aac ttg agt gtg gag cct cct tcc cct aca gac gaa gat aca     2395
 Glu Leu Asn Leu Ser Val Glu Pro Pro Ser Pro Thr Asp Glu Asp Thr
                 635                 640                 645

 cag ggg cct aac aga ttg tgg aac cca cat ctc agg ggc tat tcc tca     2443
 Gln Gly Pro Asn Arg Leu Trp Asn Pro His Leu Arg Gly Tyr Ser Ser
             650                 655                 660

 gga aag tca gtg gca aga aca tct ctg cag gct gag gac agc aat cag     2491
 Gly Lys Ser Val Ala Arg Thr Ser Leu Gln Ala Glu Asp Ser Asn Gln
         665                 670                 675

 aaa gcc tca tct cgc ttg gat gat ggg act acc gat cac agg cac ctg     2539
 Lys Ala Ser Ser Arg Leu Asp Asp Gly Thr Thr Asp His Arg His Leu
     680                 685                 690

 aag cct gcc acc cct cct tat cca atg cct tcc act ctc tca cac atg     2587
 Lys Pro Ala Thr Pro Pro Tyr Pro Met Pro Ser Thr Leu Ser His Met
 695                 700                 705                 710

 cca acc cct gat ttc acg acc agc tgg atg tct ggt act ttg gaa caa     2635
 Pro Thr Pro Asp Phe Thr Thr Ser Trp Met Ser Gly Thr Leu Glu Gln
                 715                 720                 725

 gcc caa cag gga aag cga gag aaa ctg ggt gtc cag gtt agg cca gaa     2683
 Ala Gln Gln Gly Lys Arg Glu Lys Leu Gly Val Gln Val Arg Pro Glu
             730                 735                 740

 aat tgg tgc tct cag atg gac aaa gga atg ctg cac ttt ggc tcc agt     2731
 Asn Trp Cys Ser Gln Met Asp Lys Gly Met Leu His Phe Gly Ser Ser
         745                 750                 755

 gac atc agt ccc tat gcg ctg ccg tgg cgt ccg gag gag cct gca cgt     2779
 Asp Ile Ser Pro Tyr Ala Leu Pro Trp Arg Pro Glu Glu Pro Ala Arg
     760                 765                 770

 atc agc tgg aag cag tat atg tct ggc agt gca gtc gat gtt tcc tgc     2827
 Ile Ser Trp Lys Gln Tyr Met Ser Gly Ser Ala Val Asp Val Ser Cys
 775                 780                 785                 790

 agc cag aag ccc cag ggg ctg aca cta tca aat gtg gcc cgg tgc tcc     2875
 Ser Gln Lys Pro Gln Gly Leu Thr Leu Ser Asn Val Ala Arg Cys Ser
                 795                 800                 805

 agc atg gac aat ggc cta gaa gac cag aac tcc cct ttc cac tcc cac     2923
 Ser Met Asp Asn Gly Leu Glu Asp Gln Asn Ser Pro Phe His Ser His
             810                 815                 820

 ctc agc act tac gcc aat att tgt gat ctg tca acc aca cac agc agc     2971
 Leu Ser Thr Tyr Ala Asn Ile Cys Asp Leu Ser Thr Thr His Ser Ser
         825                 830                 835

 act gag aat gcc cag ggt tca aat gag gcc tgg gaa gta ttc cga ggg     3019
 Thr Glu Asn Ala Gln Gly Ser Asn Glu Ala Trp Glu Val Phe Arg Gly
     840                 845                 850

 agt tct tca att gcc tta gga gac ccc cac atc ccg acg agc cct gaa     3067
 Ser Ser Ser Ile Ala Leu Gly Asp Pro His Ile Pro Thr Ser Pro Glu
 855                 860                 865                 870

 gga gta gcc ccc act tcg ggt cat gac aga agg cct cag ttc agg ggc     3115
 Gly Val Ala Pro Thr Ser Gly His Asp Arg Arg Pro Gln Phe Arg Gly
                 875                 880                 885

 cct tct ggt gaa gca gac tgt ctg agg agt aag ccc ccc ttg gcc aaa     3163
 Pro Ser Gly Glu Ala Asp Cys Leu Arg Ser Lys Pro Pro Leu Ala Lys
             890                 895                 900

 gga agt gct gca ggt cca gtg gat gag att atg ctg ctg tat cca tca     3211
 Gly Ser Ala Ala Gly Pro Val Asp Glu Ile Met Leu Leu Tyr Pro Ser
         905                 910                 915

 gag gca ggc tgc cct gtg gga cag acc agg acg aac aca ttc gaa cag     3259
 Glu Ala Gly Cys Pro Val Gly Gln Thr Arg Thr Asn Thr Phe Glu Gln
     920                 925                 930

 ggc aca cag acc ctc ggc agc agg cgc cac tgg agc agc act gac atc     3307
 Gly Thr Gln Thr Leu Gly Ser Arg Arg His Trp Ser Ser Thr Asp Ile
 935                 940                 945                 950

 tcc ttt gct cag cct gaa gcc agt gca gta tca gcc ttt gat ctg gcc     3355
 Ser Phe Ala Gln Pro Glu Ala Ser Ala Val Ser Ala Phe Asp Leu Ala
                 955                 960                 965

 tca tgg acc agc atg cac aat ctg tct ctc cac ctc tca cag ctc ctg     3403
 Ser Trp Thr Ser Met His Asn Leu Ser Leu His Leu Ser Gln Leu Leu
             970                 975                 980

 cac agt acc tca gag ctg ctt ggg agt ctc tcc cag cca gat gtg gcc     3451
 His Ser Thr Ser Glu Leu Leu Gly Ser Leu Ser Gln Pro Asp Val Ala
         985                 990                 995

 aga agg gag cag aac acc aag agg gac atc cca gat aaa gcc cca cag     3499
 Arg Arg Glu Gln Asn Thr Lys Arg Asp Ile Pro Asp Lys Ala Pro Gln
    1000                1005                1010

 gcc ctg atg atg gat ggc tct act cag acc act gtg gat gag ggc agc     3547
 Ala Leu Met Met Asp Gly Ser Thr Gln Thr Thr Val Asp Glu Gly Ser
1015                1020                1025                1030

 cag act gac ctc acc tta ccc acc ctg tgc ctc cag act tca gag gct     3595
 Gln Thr Asp Leu Thr Leu Pro Thr Leu Cys Leu Gln Thr Ser Glu Ala
                1035                1040                1045

 gaa cct cag gga gcc aat gtg atc ctt gaa ggg cta ggc tca gat acc     3643
 Glu Pro Gln Gly Ala Asn Val Ile Leu Glu Gly Leu Gly Ser Asp Thr
            1050                1055                1060

 tcg act gtg tct caa gaa gag gga gat gtg cca ggg gta cct cag aag     3691
 Ser Thr Val Ser Gln Glu Glu Gly Asp Val Pro Gly Val Pro Gln Lys
        1065                1070                1075

 aga gag gca gag gaa aca gca cag aaa atg gct cag ctc ctc tat ctt     3739
 Arg Glu Ala Glu Glu Thr Ala Gln Lys Met Ala Gln Leu Leu Tyr Leu
    1080                1085                1090

 cag gaa gaa agc act ccc tac aag ccc cag agc cct tca ata ccc tca     3787
 Gln Glu Glu Ser Thr Pro Tyr Lys Pro Gln Ser Pro Ser Ile Pro Ser
1095                1100                1105                1110

 tcc cac ttg agg ttt cag aaa gcc ccc gtt ggg cag cat ctt cct tct     3835
 Ser His Leu Arg Phe Gln Lys Ala Pro Val Gly Gln His Leu Pro Ser
                1115                1120                1125

 gtg agc ccc tca gtt tct gat gct ttc ctg cct ccc agc tcc cag cca     3883
 Val Ser Pro Ser Val Ser Asp Ala Phe Leu Pro Pro Ser Ser Gln Pro
            1130                1135                1140

 gag gag tca tat tgc tta gtt gtc agc agt ccc agt ccc agc tcc cct     3931
 Glu Glu Ser Tyr Cys Leu Val Val Ser Ser Pro Ser Pro Ser Ser Pro
        1145                1150                1155

 cat tcc cca ggg ctc ttt ccc agt act tcc gag tat cct ggg gac tcc     3979
 His Ser Pro Gly Leu Phe Pro Ser Thr Ser Glu Tyr Pro Gly Asp Ser
    1160                1165                1170

 agg gtc cag aag aag ctg ggc ccc aca agt gct ttg ttc gtg gac agg     4027
 Arg Val Gln Lys Lys Leu Gly Pro Thr Ser Ala Leu Phe Val Asp Arg
1175                1180                1185                1190

 gcc tcc tcc cca atc ctc act ctt agt gcc agc acc caa gag ccg ggt     4075
 Ala Ser Ser Pro Ile Leu Thr Leu Ser Ala Ser Thr Gln Glu Pro Gly
                1195                1200                1205

 ctt tcc cca ggc tct ttg acc ctc tca gcc cct tca act cac cct gtt     4123
 Leu Ser Pro Gly Ser Leu Thr Leu Ser Ala Pro Ser Thr His Pro Val
            1210                1215                1220

 gaa ggc cac cag aag ctt gac tcc agc cca gac cct gtt gat gcc cca     4171
 Glu Gly His Gln Lys Leu Asp Ser Ser Pro Asp Pro Val Asp Ala Pro
        1225                1230                1235

 agg act cca atg gat aat tat tcc caa acc act gac gag tta ggt ggc     4219
 Arg Thr Pro Met Asp Asn Tyr Ser Gln Thr Thr Asp Glu Leu Gly Gly
    1240                1245                1250

 tcc cag aga ggt aga agt tcc tta caa agg agt aat ggg aga tcc ttc     4267
 Ser Gln Arg Gly Arg Ser Ser Leu Gln Arg Ser Asn Gly Arg Ser Phe
1255                1260                1265                1270

 ctt gag ttg cac tcc cca cac agc cca cag cag agt cca aaa ctc caa     4315
 Leu Glu Leu His Ser Pro His Ser Pro Gln Gln Ser Pro Lys Leu Gln
                1275                1280                1285

 ttt agt ttc tta ggg cag cac cct cag cag ctt cag ccc agg aca act     4363
 Phe Ser Phe Leu Gly Gln His Pro Gln Gln Leu Gln Pro Arg Thr Thr
            1290                1295                1300

 atc ggg gtc caa agc aga ctg ctg cca cca cca ctg agg cac agg agc     4411
 Ile Gly Val Gln Ser Arg Leu Leu Pro Pro Pro Leu Arg His Arg Ser
        1305                1310                1315

 caa agg ctg ggc aac agc ttt gtg cct gag aag gtg gct tcc ccg gag     4459
 Gln Arg Leu Gly Asn Ser Phe Val Pro Glu Lys Val Ala Ser Pro Glu
    1320                1325                1330

 cat tgc cca ctg agc ggt agg gag cca agt cag tgg cag agc agg aca     4507
 His Cys Pro Leu Ser Gly Arg Glu Pro Ser Gln Trp Gln Ser Arg Thr
1335                1340                1345                1350

 gaa aat gga ggt gag agt tca gca tct cca ggg gaa cca caa cgc act     4555
 Glu Asn Gly Gly Glu Ser Ser Ala Ser Pro Gly Glu Pro Gln Arg Thr
                1355                1360                1365

 ctg gac cga cct tct tca tgg gga ggc ctc cag cac ctc agc ccc tgc     4603
 Leu Asp Arg Pro Ser Ser Trp Gly Gly Leu Gln His Leu Ser Pro Cys
            1370                1375                1380

 cct gtc tct gag ttg act gat act gca ggg ctc cga ggt tct gcc ttg     4651
 Pro Val Ser Glu Leu Thr Asp Thr Ala Gly Leu Arg Gly Ser Ala Leu
        1385                1390                1395

 ggc ctc cct cag gcc tgc caa cct gag gag tta ctg tgc ttc agt tgc     4699
 Gly Leu Pro Gln Ala Cys Gln Pro Glu Glu Leu Leu Cys Phe Ser Cys
    1400                1405                1410

 cag atg tgc atg gcc cct gag cac cag cac cac agt ctg agg gac ctc     4747
 Gln Met Cys Met Ala Pro Glu His Gln His His Ser Leu Arg Asp Leu
1415                1420                1425                1430

 ccg gtg cat aac aaa ttt agt aac tgg tgt ggg gtt cag aag ggc tca     4795
 Pro Val His Asn Lys Phe Ser Asn Trp Cys Gly Val Gln Lys Gly Ser
                1435                1440                1445

 cct ggg ggg ttg gac atg act gag gag gag ctg ggg gcc agc ggt gat     4843
 Pro Gly Gly Leu Asp Met Thr Glu Glu Glu Leu Gly Ala Ser Gly Asp
            1450                1455                1460

 ctc agc tct gaa aag cag gaa cag agt ccc cca caa cct cct aat gac     4891
 Leu Ser Ser Glu Lys Gln Glu Gln Ser Pro Pro Gln Pro Pro Asn Asp
        1465                1470                1475

 cac agc cag gat tct gag tgg tcc aag agg gag cag atc ccc ctg caa     4939
 His Ser Gln Asp Ser Glu Trp Ser Lys Arg Glu Gln Ile Pro Leu Gln
    1480                1485                1490

 gtt ggg gcc cag aac ctc tca ctc agc gtg gaa ctc aca gaa gcg aaa     4987
 Val Gly Ala Gln Asn Leu Ser Leu Ser Val Glu Leu Thr Glu Ala Lys
1495                1500                1505                1510

 ctg cac cat ggc ttt ggg gag gcc gat gcc ctg ctc cag gtg ctg cag     5035
 Leu His His Gly Phe Gly Glu Ala Asp Ala Leu Leu Gln Val Leu Gln
                1515                1520                1525

 agt ggg aca ggg gag gcg ctt gct gct gat gaa cct gtg aca tcc acc     5083
 Ser Gly Thr Gly Glu Ala Leu Ala Ala Asp Glu Pro Val Thr Ser Thr
            1530                1535                1540

 tgg aag gag ctc tat gca cgg caa aaa aag gcc att gag acc ctc agg     5131
 Trp Lys Glu Leu Tyr Ala Arg Gln Lys Lys Ala Ile Glu Thr Leu Arg
        1545                1550                1555

 aga gag cgg gct gag cga ctt ggg aac ttc tgc cgg acg cga agc ctt     5179
 Arg Glu Arg Ala Glu Arg Leu Gly Asn Phe Cys Arg Thr Arg Ser Leu
    1560                1565                1570

 agc cct cag aaa caa ctg agc ctc ctg ccc aac aaa gat ctc ttc atc     5227
 Ser Pro Gln Lys Gln Leu Ser Leu Leu Pro Asn Lys Asp Leu Phe Ile
1575                1580                1585                1590

 tgg gat ctt gac ttg ccc agc aga cgc cga gaa tac ctg cag caa ctg     5275
 Trp Asp Leu Asp Leu Pro Ser Arg Arg Arg Glu Tyr Leu Gln Gln Leu
                1595                1600                1605

 agg aag gat gtt gtg gag acc acc agg agc cca gag tca gtg tca agg     5323
 Arg Lys Asp Val Val Glu Thr Thr Arg Ser Pro Glu Ser Val Ser Arg
            1610                1615                1620

 tca gct cac aca ccc tct gac ata gag ttg atg ctg caa gac tac cag     5371
 Ser Ala His Thr Pro Ser Asp Ile Glu Leu Met Leu Gln Asp Tyr Gln
        1625                1630                1635

 cag gcc cat gag gag gcc aag gtg gag att gcc cgg gcc cga gac caa     5419
 Gln Ala His Glu Glu Ala Lys Val Glu Ile Ala Arg Ala Arg Asp Gln
    1640                1645                1650

 ctg cgg gag cgg act gaa caa gag aag ctg aga atc cac cag aag atc     5467
 Leu Arg Glu Arg Thr Glu Gln Glu Lys Leu Arg Ile His Gln Lys Ile
1655                1660                1665                1670

 att tcc cag cta ttg aag gaa gag gat aaa cta cat acc ttg gcc aat     5515
 Ile Ser Gln Leu Leu Lys Glu Glu Asp Lys Leu His Thr Leu Ala Asn
                1675                1680                1685

 tcc agc tcc ctg tgc acc agc tct aat gga agc ctc tcg tct ggc atg     5563
 Ser Ser Ser Leu Cys Thr Ser Ser Asn Gly Ser Leu Ser Ser Gly Met
            1690                1695                1700

 acc tct ggc tat aat agc agc cca gcc ttg tca ggc cag ctc cag ttc     5611
 Thr Ser Gly Tyr Asn Ser Ser Pro Ala Leu Ser Gly Gln Leu Gln Phe
        1705                1710                1715

 cca gag aat atg ggg cat aca aac ttg cct gat tcc agg gat gta tgg     5659
 Pro Glu Asn Met Gly His Thr Asn Leu Pro Asp Ser Arg Asp Val Trp
    1720                1725                1730

 ata ggg gat gag cga gga ggc cat tct gca gtg agg aag aac tct gcc     5707
 Ile Gly Asp Glu Arg Gly Gly His Ser Ala Val Arg Lys Asn Ser Ala
1735                1740                1745                1750

 tac agc cac aga gcc tcc ctg ggc agt tgc tgc tgt tca cca tcc agt     5755
 Tyr Ser His Arg Ala Ser Leu Gly Ser Cys Cys Cys Ser Pro Ser Ser
                1755                1760                1765

 ctg tcc agc ttg ggg acc tgc ttt tcc tcc tcc tac cag gat ttg gcc     5803
 Leu Ser Ser Leu Gly Thr Cys Phe Ser Ser Ser Tyr Gln Asp Leu Ala
            1770                1775                1780

 aag cat gtc gtg gac act tct atg gct gat gta atg gct gct tgt tcg     5851
 Lys His Val Val Asp Thr Ser Met Ala Asp Val Met Ala Ala Cys Ser
        1785                1790                1795

 gat aat ttg cac aac ctc ttc agc tgc cag gca act gct ggc tgg aac     5899
 Asp Asn Leu His Asn Leu Phe Ser Cys Gln Ala Thr Ala Gly Trp Asn
    1800                1805                1810

 tat cag ggt gag gag cag gcg gtg cag ctt tac tac aag gtg ttt tct     5947
 Tyr Gln Gly Glu Glu Gln Ala Val Gln Leu Tyr Tyr Lys Val Phe Ser
1815                1820                1825                1830

 ccc act cgg cat ggc ttc ctg ggg gca ggt gtg gtg tcc cag ccg ctg     5995
 Pro Thr Arg His Gly Phe Leu Gly Ala Gly Val Val Ser Gln Pro Leu
                1835                1840                1845

 tct cgt gtg tgg gcg gct gtc agt gac ccc act gtg tgg ccc ctg tat     6043
 Ser Arg Val Trp Ala Ala Val Ser Asp Pro Thr Val Trp Pro Leu Tyr
            1850                1855                1860

 tac aag ccc atc cag aca gca agg ctg cat cag cga gtg acc aac agc     6091
 Tyr Lys Pro Ile Gln Thr Ala Arg Leu His Gln Arg Val Thr Asn Ser
        1865                1870                1875

 atc agc ctg gtg tac ttg gtg tgc aac acc acc ctg tgc gca ctg aag     6139
 Ile Ser Leu Val Tyr Leu Val Cys Asn Thr Thr Leu Cys Ala Leu Lys
    1880                1885                1890

 cag cca cgg gat ttc tgt tgt gtc tgc gtg gaa gcc aaa gag ggt cac     6187
 Gln Pro Arg Asp Phe Cys Cys Val Cys Val Glu Ala Lys Glu Gly His
1895                1900                1905                1910

 ctg tct gtc atg gca gcc cag tct gtg tat gat aca tcc atg cca aga     6235
 Leu Ser Val Met Ala Ala Gln Ser Val Tyr Asp Thr Ser Met Pro Arg
                1915                1920                1925

 ccc agc aga aaa atg gtt cgc ggg gag atc ctg ccc agt gcc tgg atc     6283
 Pro Ser Arg Lys Met Val Arg Gly Glu Ile Leu Pro Ser Ala Trp Ile
            1930                1935                1940

 ttg cag ccc atc act gtg gaa ggg aag gaa gtc acc aga gtc atc tac     6331
 Leu Gln Pro Ile Thr Val Glu Gly Lys Glu Val Thr Arg Val Ile Tyr
        1945                1950                1955

 ttg gcc cag gtg gaa ctt ggt gct cca ggc ttc cca cct cag ctc ctg     6379
 Leu Ala Gln Val Glu Leu Gly Ala Pro Gly Phe Pro Pro Gln Leu Leu
    1960                1965                1970

 agc tct ttc atc aaa cgg cag cca ctg gtt ata gcc aga ctg gct tcc     6427
 Ser Ser Phe Ile Lys Arg Gln Pro Leu Val Ile Ala Arg Leu Ala Ser
1975                1980                1985                1990

 ttc ctt ggt agg tag catctcaccg tcaagatggt gctgctgaga tgcaggccca     6482
 Phe Leu Gly Arg 


 ggctgctcaa gagagacact gtggcagctc cttgttactt tccataccac agtgcaggaa   6542

 aagctgatgc tacctgctgt ggccgattgg ggcagacagc actggcccag ggatgctagc   6602

 aaagcccagt cagtacttgg tcacagctgg caccagtgca gagcaaacgg cctgagctcc   6662

 tggcccagac tatccagagt gaatgcagct ccgctcacct tttggatttc tcacctttct   6722

 ttcctgtttc tgggactctg cggcagacag gacacttaag gaccaggact gggcacagcc   6782

 agcagagccg gggactgcag tgctttggca aggtgcttcc gcaggctggt agggaagcag   6842

 gcagccactg gccaagactc tgctctgaat ctacctcctc tagcattcag ctctactgtg   6902

 tgatgggacg ttaaaaatac caaaacagaa agagggttta agaaacagct gcacaaacca   6962

 gaacaccgat tcagaatctt ttctccctct tgagtttttg caaaatactt tattattgat   7022

 ttttgctttt tttctccctt tccctcccag gagaagacat ttgggtcttg gcctgaggca   7082

 ggggtgttga gcgatgatgc tctgatatgg agctgtcact ctagagctcg gtcagatgga   7142

 agacactata gaaccaggtt ggacagattt ggggtcaggg ttggaggctg agttcttttg   7202

 aggactggtt ggagtggcag ccagatggtg gctgctgaca aggcaagagg aatttcagag   7262

 attaaacatt gtcctttgag gaagggagag gaggtgaatg aactcccaga ggaggtgagt   7322

 ggcttgttgg gaggaagctc agttccagaa cttacctcag tgcacttggg aggggtggag   7382

 tcctgagcat tccatgattt ctgccctggc cccacctatc ctaggatggg gtgggatgga   7442

 gagtgggttc agttttcttg tactttagcc tggctgaaca tgaactttgt gtttacctgg   7502

 aagtggtagg ggtgggagag attctcatct ttagttctgg tgcccaaaat ctttggtaga   7562

 tggagggaac tggggattca gaagatgtgg taaaggtcta tttctgtagt gtggcagaga   7622

 tgtgtttttc taaagtgttt gcagggcatt tttccctctt acctcagatt aagttattta   7682

 tatattgttg attgaaggtt ttttaaaatt gcttttaaac ttctatttct cgggtaaatt   7742

 ttttggtgac atgatatatt taacacccta tttatatact cctacctctt ttcatataaa   7802

 tctcttacta agactactga ccaaaaaaga acattttaaa attaaaaaaa aaaaaaaaa    7861




      <210> 304
      <211> 940
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (593)..(886)

      <400> 304
 cccttttcat atttctcata tccgatctca cacacaactt cctggggcca ctatctctag     60

 gtaatgatag agcagataaa ttcatcagtt ctatatttca acaagcccaa gcttcccatg    120

 ctttactgca tcagaacaac ttgcccttac tcgtatgttt catctgcctc gcagccaggc    180

 ttgagttatt gtgcaagcct gccccacttg ccagcatgtc cctggtgttg cacctgtgga    240

 aggatgcaac ccacgaggct tggctccaaa tgaaatctgg cagatggatg ttacatatat    300

 atagcagcct ttggctaact ccgctatgtt catgtaatat agacacttac tcccatatgt    360

 tacatgccac atgccaaact ggggaaacag ctggtcatgt ctgacgatac tgtctgtcgt    420

 catttgccca tatgggggtc cctaaacaat ttaaaactga cagtggactc gcttatgtta    480

 gtcatgcttt cccaattttt tacaattgtg ggcaatcaat cataaaacag gaattccata    540

 caatccctga gggccaggca ttattgagcg ggtacatcaa acactacaac gc    atg     595
                                                              Met
                                                                1

 ctg aaa aaa aaa aaa ggg aga ata ggg gac caa tta cca ctt caa aca      643
 Leu Lys Lys Lys Lys Gly Arg Ile Gly Asp Gln Leu Pro Leu Gln Thr
               5                  10                  15

 aaa tta cat tta gcc ttg ttt act tta aat tgt ttg act cct ggt acg      691
 Lys Leu His Leu Ala Leu Phe Thr Leu Asn Cys Leu Thr Pro Gly Thr
          20                  25                  30

 gat ggc aag acc cca gca gaa cga cac tgg caa ctg cta gag gaa aag      739
 Asp Gly Lys Thr Pro Ala Glu Arg His Trp Gln Leu Leu Glu Glu Lys
      35                  40                  45

 agg caa gtt tat cca aaa gtg tta tgg aaa tcc cca gaa gaa gga caa      787
 Arg Gln Val Tyr Pro Lys Val Leu Trp Lys Ser Pro Glu Glu Gly Gln
  50                  55                  60                  65

 tgg aaa ggt ccg gtg gat ttg ctg acg tgg gga cga ggg tat gct tgt      835
 Trp Lys Gly Pro Val Asp Leu Leu Thr Trp Gly Arg Gly Tyr Ala Cys
                  70                  75                  80

 gtt ttt aca gga gat gga caa acc gtg tgg gtg ccc tcc agg tgt gtg      883
 Val Phe Thr Gly Asp Gly Gln Thr Val Trp Val Pro Ser Arg Cys Val
              85                  90                  95

 tga ccat ggaacgggag accggaggga tccatggtat tcaaccgtgg gcctgttacc      940
 






      <210> 305
      <211> 3644
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (424)..(3597)

      <400> 305
 gataccgctc cggaatttcc gggtcgacga ttctcgagcc gacccacgga gtcttgtctc     60

 ctgcttgtgg gtggagggga gcttccgaag gaggccagcg aagaaccctg caaagcggtg    120

 aggacccagc atccggcccc tcgcccctgg cgagcaaacg ggtcagaccg ttaggcacag    180

 cctccttgtg gagcgcacgg acaggaagca gggtttatag cacctagagg gggaaggagt    240

 ggcaagtgcg gagggcagcc cctcccagga ctagaaccca cttcctactt tacaccagca    300

 ctggaggagg ctggtggggc agggcggggg cggtggggcc tcccctagcc ttccctcccc    360

 ctctccttca ctgtccttcc agcaggcaca ggaaggtgag gcaaggtgtt tccagccggc    420

 agg  atg gag gac gag gaa ggc cct gag tat ggc aaa cct gac ttt gtg     468
      Met Glu Asp Glu Glu Gly Pro Glu Tyr Gly Lys Pro Asp Phe Val
        1               5                  10                  15

 ctt ttg gac caa gtg acc atg gag gac ttc atg agg aac ctg cag ctc      516
 Leu Leu Asp Gln Val Thr Met Glu Asp Phe Met Arg Asn Leu Gln Leu
                  20                  25                  30

 agg ttc gag aag ggc cgc atc tac acc tac atc ggt gag gtg ctg gtg      564
 Arg Phe Glu Lys Gly Arg Ile Tyr Thr Tyr Ile Gly Glu Val Leu Val
              35                  40                  45

 tcc gtg aac ccc tac cag gag ctg ccc ctg tat ggg cct gag gcc atc      612
 Ser Val Asn Pro Tyr Gln Glu Leu Pro Leu Tyr Gly Pro Glu Ala Ile
          50                  55                  60

 gcc agg tac cag ggc cgt gag ctc tat gag cgg cca ccc cat ctc tat      660
 Ala Arg Tyr Gln Gly Arg Glu Leu Tyr Glu Arg Pro Pro His Leu Tyr
      65                  70                  75

 gct gtg gcc aac gcc gcc tac aag gca atg aag cac cgg tcc agg gac      708
 Ala Val Ala Asn Ala Ala Tyr Lys Ala Met Lys His Arg Ser Arg Asp
  80                  85                  90                  95

 acc tgc atc gtc atc tca ggg gag agt ggg gca ggg aag aca gaa gcc      756
 Thr Cys Ile Val Ile Ser Gly Glu Ser Gly Ala Gly Lys Thr Glu Ala
                 100                 105                 110

 agt aag cac atc atg cag tac atc gct gct gtc acc aat cca agc cag      804
 Ser Lys His Ile Met Gln Tyr Ile Ala Ala Val Thr Asn Pro Ser Gln
             115                 120                 125

 agg gct gag gtg gag agg gtc aag gac gtg ctg ctc aag tcc acc tgt      852
 Arg Ala Glu Val Glu Arg Val Lys Asp Val Leu Leu Lys Ser Thr Cys
         130                 135                 140

 gtg ctg gag gcc ttt ggc aat gcc cgc acc aac cgc aat cac aac tcc      900
 Val Leu Glu Ala Phe Gly Asn Ala Arg Thr Asn Arg Asn His Asn Ser
     145                 150                 155

 agc cgc ttt ggc aag tac atg gac atc aac ttt gac ttc aag ggg gac      948
 Ser Arg Phe Gly Lys Tyr Met Asp Ile Asn Phe Asp Phe Lys Gly Asp
 160                 165                 170                 175

 ccg atc gga gga cac atc cac agc tac cta ctg gag aag tct cgg gtc      996
 Pro Ile Gly Gly His Ile His Ser Tyr Leu Leu Glu Lys Ser Arg Val
                 180                 185                 190

 ctc aag cag cac gtg ggt gaa aga aac ttc cac gcc ttc tac caa ttg     1044
 Leu Lys Gln His Val Gly Glu Arg Asn Phe His Ala Phe Tyr Gln Leu
             195                 200                 205

 ctg aga ggc agt gag gac aag cag ctg cat gaa ctg cac ttg gag aga     1092
 Leu Arg Gly Ser Glu Asp Lys Gln Leu His Glu Leu His Leu Glu Arg
         210                 215                 220

 aac cct gct gta tac aat ttc aca cac cag gga gca gga ctc aac atg     1140
 Asn Pro Ala Val Tyr Asn Phe Thr His Gln Gly Ala Gly Leu Asn Met
     225                 230                 235

 act gtg cac agt gcc ttg gac agt gat gag cag agc cac cag gca gtg     1188
 Thr Val His Ser Ala Leu Asp Ser Asp Glu Gln Ser His Gln Ala Val
 240                 245                 250                 255

 acc gag gcc atg agg gtc atc ggc ttc agt cct gaa gag gtg gag tct     1236
 Thr Glu Ala Met Arg Val Ile Gly Phe Ser Pro Glu Glu Val Glu Ser
                 260                 265                 270

 gtg cat cgc atc ctg gct gcc ata ttg cac ctg gga aac atc gag ttt     1284
 Val His Arg Ile Leu Ala Ala Ile Leu His Leu Gly Asn Ile Glu Phe
             275                 280                 285

 gtg gag acg gag gag ggt ggg ctg cag aag gag ggc ctg gca gtg gcc     1332
 Val Glu Thr Glu Glu Gly Gly Leu Gln Lys Glu Gly Leu Ala Val Ala
         290                 295                 300

 gag gag gca ctg gtg gac cat gtg gct gag ctg acg gcc aca ccc cgg     1380
 Glu Glu Ala Leu Val Asp His Val Ala Glu Leu Thr Ala Thr Pro Arg
     305                 310                 315

 gac ctc gtg ctc cgc tcc ctg ctg gct cgc aca gtt gcc tcg gga ggc     1428
 Asp Leu Val Leu Arg Ser Leu Leu Ala Arg Thr Val Ala Ser Gly Gly
 320                 325                 330                 335

 agg gaa ctc ata gag aag ggc cac act gca gct gag gcc agc tat gcc     1476
 Arg Glu Leu Ile Glu Lys Gly His Thr Ala Ala Glu Ala Ser Tyr Ala
                 340                 345                 350

 cgg gat gcc tgt gcc aag gca gtg tac cag cgg ctg ttt gag tgg gtg     1524
 Arg Asp Ala Cys Ala Lys Ala Val Tyr Gln Arg Leu Phe Glu Trp Val
             355                 360                 365

 gtg aac agg atc aac agt gtc atg gaa ccc cgg ggc cgg gat cct cgg     1572
 Val Asn Arg Ile Asn Ser Val Met Glu Pro Arg Gly Arg Asp Pro Arg
         370                 375                 380

 cgt gat ggc aag gac aca gtc att ggc gtg ctg gac atc tat ggc ttc     1620
 Arg Asp Gly Lys Asp Thr Val Ile Gly Val Leu Asp Ile Tyr Gly Phe
     385                 390                 395

 gag gtg ttt ccc gtc aac agt ttc gag cag ttc tgc atc aac tac tgc     1668
 Glu Val Phe Pro Val Asn Ser Phe Glu Gln Phe Cys Ile Asn Tyr Cys
 400                 405                 410                 415

 aat gag aag ctg cag cag cta ttc atc cag ctc atc ctg aag cag gaa     1716
 Asn Glu Lys Leu Gln Gln Leu Phe Ile Gln Leu Ile Leu Lys Gln Glu
                 420                 425                 430

 cag gaa gag tac gag cgc gag ggc atc acc tgg cag agc gtt gag tat     1764
 Gln Glu Glu Tyr Glu Arg Glu Gly Ile Thr Trp Gln Ser Val Glu Tyr
             435                 440                 445

 ttc aac aac gcc acc att gtg gat ctg gtg gag cgg ccc cac cgt ggc     1812
 Phe Asn Asn Ala Thr Ile Val Asp Leu Val Glu Arg Pro His Arg Gly
         450                 455                 460

 atc ctg gcc gtg ctg gac gag gcc tgc agc tct gct ggc acc atc act     1860
 Ile Leu Ala Val Leu Asp Glu Ala Cys Ser Ser Ala Gly Thr Ile Thr
     465                 470                 475

 gac cga atc ttc ctg cag acc ctg gac acg cac cac cgc cat cac cta     1908
 Asp Arg Ile Phe Leu Gln Thr Leu Asp Thr His His Arg His His Leu
 480                 485                 490                 495

 cac tac acc agc cgc cag gtg ccc ccg gct gtc cca gtg cca cca cag     1956
 His Tyr Thr Ser Arg Gln Val Pro Pro Ala Val Pro Val Pro Pro Gln
                 500                 505                 510

 tgg gct gac aag acc atg gag ttt ggc cga gac ttc cgg atc aag cac     2004
 Trp Ala Asp Lys Thr Met Glu Phe Gly Arg Asp Phe Arg Ile Lys His
             515                 520                 525

 tat gca ggg gac gtc acg tac tcc gtg gaa ggc ttc atc gac aag aac     2052
 Tyr Ala Gly Asp Val Thr Tyr Ser Val Glu Gly Phe Ile Asp Lys Asn
         530                 535                 540

 aga gat ttc ctc ttc cag gac ttc aag cgg ctg ctg tac aac agc acg     2100
 Arg Asp Phe Leu Phe Gln Asp Phe Lys Arg Leu Leu Tyr Asn Ser Thr
     545                 550                 555

 gac ccc act cta cgg gcc atg tgg ccg gac ggg cag cag gac atc aca     2148
 Asp Pro Thr Leu Arg Ala Met Trp Pro Asp Gly Gln Gln Asp Ile Thr
 560                 565                 570                 575

 gag gtg acc aag cgc ccc ctg acg gct ggc aca ctc ttc aag aac tcc     2196
 Glu Val Thr Lys Arg Pro Leu Thr Ala Gly Thr Leu Phe Lys Asn Ser
                 580                 585                 590

 atg gtg gcc ctg gtg gag aac ctt gcc tcc aag gag ccc ttc tac gtc     2244
 Met Val Ala Leu Val Glu Asn Leu Ala Ser Lys Glu Pro Phe Tyr Val
             595                 600                 605

 cgc tgc atc aag ccc aat gag gac aag gta gct ggg aag ctg gat gag     2292
 Arg Cys Ile Lys Pro Asn Glu Asp Lys Val Ala Gly Lys Leu Asp Glu
         610                 615                 620

 aac cac tgt cgc cac cag gtc gca tac ctg ggg ctg ctg gag aat gtg     2340
 Asn His Cys Arg His Gln Val Ala Tyr Leu Gly Leu Leu Glu Asn Val
     625                 630                 635

 agg gtc cgc agg gct ggc ttc gct tcc cgc cag ccc tac tct cga ttc     2388
 Arg Val Arg Arg Ala Gly Phe Ala Ser Arg Gln Pro Tyr Ser Arg Phe
 640                 645                 650                 655

 ctg ctc agg tac tgg cac ctg aca ccc atc act cca tgg gcc ata gtc     2436
 Leu Leu Arg Tyr Trp His Leu Thr Pro Ile Thr Pro Trp Ala Ile Val
                 660                 665                 670

 cct gtg tgg agt cca agg ggc ctg ggc cac act gcc ctg tcc tgt ggt     2484
 Pro Val Trp Ser Pro Arg Gly Leu Gly His Thr Ala Leu Ser Cys Gly
             675                 680                 685

 gac agg tac aag atg acc tgt gaa tac aca tgg ccc aac cac ctg ctg     2532
 Asp Arg Tyr Lys Met Thr Cys Glu Tyr Thr Trp Pro Asn His Leu Leu
         690                 695                 700

 ggc tcc gac aag gca gcc gtg agc gct ctc ctg gag cag cac ggg ctg     2580
 Gly Ser Asp Lys Ala Ala Val Ser Ala Leu Leu Glu Gln His Gly Leu
     705                 710                 715

 cag ggg gac gtg gcc ttt ggc cac agc aag ctg ttc atc cgc tca ccc     2628
 Gln Gly Asp Val Ala Phe Gly His Ser Lys Leu Phe Ile Arg Ser Pro
 720                 725                 730                 735

 cgg aca ctg gtc aca ctg gag cag agc cga gcc cgc ctc atc ccc atc     2676
 Arg Thr Leu Val Thr Leu Glu Gln Ser Arg Ala Arg Leu Ile Pro Ile
                 740                 745                 750

 att gtg ctg cta ttg cag aag gca tgg cgg ggc acc ttg gcg agg tgg     2724
 Ile Val Leu Leu Leu Gln Lys Ala Trp Arg Gly Thr Leu Ala Arg Trp
             755                 760                 765

 cgc tgc cgg agg ctg agg gct atc tac acc atc atg cgc tgg ttc cgg     2772
 Arg Cys Arg Arg Leu Arg Ala Ile Tyr Thr Ile Met Arg Trp Phe Arg
         770                 775                 780

 aga cac aag gtg cgg gct cac ctg gct gag ctg cag cgg cga ttc cag     2820
 Arg His Lys Val Arg Ala His Leu Ala Glu Leu Gln Arg Arg Phe Gln
     785                 790                 795

 gct gca agg cag ccg cca ctc tac ggg cgt gac ctt gtg tgg ccg ctg     2868
 Ala Ala Arg Gln Pro Pro Leu Tyr Gly Arg Asp Leu Val Trp Pro Leu
 800                 805                 810                 815

 ccc cct gct gtg ctg cag ccc ttc cag gac acc tgc cac gca ctc ttc     2916
 Pro Pro Ala Val Leu Gln Pro Phe Gln Asp Thr Cys His Ala Leu Phe
                 820                 825                 830

 tgc agg tgg cgg gcc cgg cag ctg gtg aag aac atc ccc cct tca gac     2964
 Cys Arg Trp Arg Ala Arg Gln Leu Val Lys Asn Ile Pro Pro Ser Asp
             835                 840                 845

 atg ccc cag atc aag gcc aag gtg gcc gcc atg ggg gcc ctg caa ggg     3012
 Met Pro Gln Ile Lys Ala Lys Val Ala Ala Met Gly Ala Leu Gln Gly
         850                 855                 860

 ctt cgt cag gac tgg ggc tgc cga cgg gcc tgg gcc cga gac tac ctg     3060
 Leu Arg Gln Asp Trp Gly Cys Arg Arg Ala Trp Ala Arg Asp Tyr Leu
     865                 870                 875

 tcc tct gcc act gac aat ccc aca gca tca agc ctg ttt gct cag cga     3108
 Ser Ser Ala Thr Asp Asn Pro Thr Ala Ser Ser Leu Phe Ala Gln Arg
 880                 885                 890                 895

 cta aag aca ctt cgg gac aaa gat ggc ttc ggg gct gtg ctc ttt tca     3156
 Leu Lys Thr Leu Arg Asp Lys Asp Gly Phe Gly Ala Val Leu Phe Ser
                 900                 905                 910

 agc cat gtc cgc aag gtg aac cgc ttc cac aag atc cgg aac cgg gcc     3204
 Ser His Val Arg Lys Val Asn Arg Phe His Lys Ile Arg Asn Arg Ala
             915                 920                 925

 ctc ctg ctc aca gac cag cac ctc tac aag ctg gac cct gac cgg cag     3252
 Leu Leu Leu Thr Asp Gln His Leu Tyr Lys Leu Asp Pro Asp Arg Gln
         930                 935                 940

 tac cgg gtg atg cgg gcc gtg ccc ctt gag gcg gtg acg ggg ctg agc     3300
 Tyr Arg Val Met Arg Ala Val Pro Leu Glu Ala Val Thr Gly Leu Ser
     945                 950                 955

 gtg acc agc gga gga gac cag ctg gtg gtg ctg cac gcc cgc ggc cag     3348
 Val Thr Ser Gly Gly Asp Gln Leu Val Val Leu His Ala Arg Gly Gln
 960                 965                 970                 975

 gac gac ctc gtg gtg tgc ctg cac cgc tcc cgg ccg cca ttg gac aac     3396
 Asp Asp Leu Val Val Cys Leu His Arg Ser Arg Pro Pro Leu Asp Asn
                 980                 985                 990

 cgc gtt ggg gag ctg gtg ggc gtg ctg gcc gca cac tgc cag ggg gag     3444
 Arg Val Gly Glu Leu Val Gly Val Leu Ala Ala His Cys Gln Gly Glu
             995                1000                1005

 ggc cgc acc ctg gag gtt cgc gtc tcc gac tgc atc cca cta agc cat     3492
 Gly Arg Thr Leu Glu Val Arg Val Ser Asp Cys Ile Pro Leu Ser His
        1010                1015                1020

 cgc ggg gtc cgg cgc ctc atc tcc gtg gag ccc agg ccg gag cag cca     3540
 Arg Gly Val Arg Arg Leu Ile Ser Val Glu Pro Arg Pro Glu Gln Pro
    1025                1030                1035

 gag ccc gat ttc cgc tgc gct cgc ggc tcc ttc acc ctg ctc tgg ccc     3588
 Glu Pro Asp Phe Arg Cys Ala Arg Gly Ser Phe Thr Leu Leu Trp Pro
1040                1045                1050                1055

 agc cgc tga gcgcccg cacccgccgc accccgaggc cgccaattgt ccgccccgcc     3644
 Ser Arg 






      <210> 306
      <211> 1964
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(1295)

      <400> 306
 gccgggaagg tcacttccgg cctgggcgcc cgtccccctg accccagggt ctgagtcgcc     60

 gctgccgccg ctgccaccat ccgcgaggca ggagagagga ggaggagtgc ggcgcggcgg    120

 ccccgggacc aaggagggac ccagac atg gag ctg cgg gaa gaa gcc tgg tct     173
                              Met Glu Leu Arg Glu Glu Ala Trp Ser
                                1               5

 ccg ggg ccg ctg gat tct gag gac cag cag atg gcc agt cac gag aac      221
 Pro Gly Pro Leu Asp Ser Glu Asp Gln Gln Met Ala Ser His Glu Asn
  10                  15                  20                  25

 cca gtg gac atc ctc atc atg gat gat gac gac gtc ccc agc tgg cct      269
 Pro Val Asp Ile Leu Ile Met Asp Asp Asp Asp Val Pro Ser Trp Pro
                  30                  35                  40

 ccc acc aag ctg tcc ccg ccc cag tct gcg ccc cca gcc ggc ccg cct      317
 Pro Thr Lys Leu Ser Pro Pro Gln Ser Ala Pro Pro Ala Gly Pro Pro
              45                  50                  55

 ccc cgg ccg cgg cgc ccc gcc ccc tac atc tgc aac gag tgt ggc aag      365
 Pro Arg Pro Arg Arg Pro Ala Pro Tyr Ile Cys Asn Glu Cys Gly Lys
          60                  65                  70

 agc ttt agc cac tgg tcc aag ctg acg cgg cac cag cgc acg cac acc      413
 Ser Phe Ser His Trp Ser Lys Leu Thr Arg His Gln Arg Thr His Thr
      75                  80                  85

 ggc gag cgg ccc aac gcc tgc gcc gac tgc ggc aag acc ttc tcg cag      461
 Gly Glu Arg Pro Asn Ala Cys Ala Asp Cys Gly Lys Thr Phe Ser Gln
  90                  95                 100                 105

 agc tcg cac ctg gtg cag cac cgg cgc atc cac acg ggc gag aag ccc      509
 Ser Ser His Leu Val Gln His Arg Arg Ile His Thr Gly Glu Lys Pro
                 110                 115                 120

 tac gcc tgc ttg gag tgc ggc aag cgc ttc agc tgg agc tcc aac ctc      557
 Tyr Ala Cys Leu Glu Cys Gly Lys Arg Phe Ser Trp Ser Ser Asn Leu
             125                 130                 135

 atg cag cac cag cgc atc cac acg ggc gag aag ccc tac acc tgc ccc      605
 Met Gln His Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Thr Cys Pro
         140                 145                 150

 gac tgc ggc cgc agc ttc act cag agc aag agc ctg gcc aag cac cgg      653
 Asp Cys Gly Arg Ser Phe Thr Gln Ser Lys Ser Leu Ala Lys His Arg
     155                 160                 165

 cgc tcg cac agc ggc ctc aag ccc ttc gtg tgc acg cgc tgc ggc cgc      701
 Arg Ser His Ser Gly Leu Lys Pro Phe Val Cys Thr Arg Cys Gly Arg
 170                 175                 180                 185

 ggc ttc agc cag ccc aag agc ctc gcg cgt cac ctg cgg ctg cac ccg      749
 Gly Phe Ser Gln Pro Lys Ser Leu Ala Arg His Leu Arg Leu His Pro
                 190                 195                 200

 gag ctg tcg ggg cct ggc gtg gcg gcc aag gtg ctg gcg gct agc gtc      797
 Glu Leu Ser Gly Pro Gly Val Ala Ala Lys Val Leu Ala Ala Ser Val
             205                 210                 215

 cgg cgg gcc aag ggg ccc gaa gag gcg gtg gcg gcg gac ggc gag atc      845
 Arg Arg Ala Lys Gly Pro Glu Glu Ala Val Ala Ala Asp Gly Glu Ile
         220                 225                 230

 gcc atc ccc gtg ggc gat ggc gag ggc atc atc gtg gtg ggc gcg ccg      893
 Ala Ile Pro Val Gly Asp Gly Glu Gly Ile Ile Val Val Gly Ala Pro
     235                 240                 245

 ggc gag ggg gcc gcg gcc gcg gca gcc atg gcg ggc gcg ggg gca aag      941
 Gly Glu Gly Ala Ala Ala Ala Ala Ala Met Ala Gly Ala Gly Ala Lys
 250                 255                 260                 265

 gcc gcg ggg ccc cgg tcg cgg cgc gcc ccg gcc ccc aag ccg tac gtg      989
 Ala Ala Gly Pro Arg Ser Arg Arg Ala Pro Ala Pro Lys Pro Tyr Val
                 270                 275                 280

 tgt ctg gag tgc ggg aag ggc ttc ggg cac ggg gcc ggg ctc ctg gcg     1037
 Cys Leu Glu Cys Gly Lys Gly Phe Gly His Gly Ala Gly Leu Leu Ala
             285                 290                 295

 cac cag cgg gcc cag cac ggg gac ggg ctc ggg gcg gcg ggg ggc gag     1085
 His Gln Arg Ala Gln His Gly Asp Gly Leu Gly Ala Ala Gly Gly Glu
         300                 305                 310

 gag ccg gcc cac atc tgc gtg gag tgc ggg gag ggc ttc gtg cag ggc     1133
 Glu Pro Ala His Ile Cys Val Glu Cys Gly Glu Gly Phe Val Gln Gly
     315                 320                 325

 gcc gcg ctc cgg aga cac aag aag atc cac gcg gtg ggc gcg ccc tcg     1181
 Ala Ala Leu Arg Arg His Lys Lys Ile His Ala Val Gly Ala Pro Ser
 330                 335                 340                 345

 gtc tgc agc agc tgc gga cag agc tac tac cgc gcg ggc ggg gag gag     1229
 Val Cys Ser Ser Cys Gly Gln Ser Tyr Tyr Arg Ala Gly Gly Glu Glu
                 350                 355                 360

 gag gac gac gac gac gag gcc gcg ggc ggg cgg tgc ccc gag tgc cgc     1277
 Glu Asp Asp Asp Asp Glu Ala Ala Gly Gly Arg Cys Pro Glu Cys Arg
             365                 370                 375

 gct ggg gag ggc cgg tag gggagg ggcccggggg ggggcgggca gggcccctcg     1331
 Ala Gly Glu Gly Arg 
         380

 ggcttggcgg gagcgacgac gtgcaagacc aagagaccca gggagaagcg gacggggtgc   1391

 gatggacccc gcggcatccc cggctccccg ccctcctctg tccctgcgcc gtccgtgggg   1451

 gggcactggg gcgtattagg gcccgttcac ttctccgcct cgagactctg ccccctcagc   1511

 ctggcccgcc cttcctaagt tatcggcctg cgagccggag agacaatgga gagaactgca   1571

 gaggccgagt ggcgaccagg ccccaagcgg aaggccattt tccctgccct tcctcagttg   1631

 tccggggcgg gggtgggggg tgctgcgagg aatggagaaa ccaggccctt tagaggatcc   1691

 cagagaggga agagaaccag gggccctttt ctcttttaga attttctttt aatcagccca   1751

 ccttttgact ccccgcccgc cccaatccat tatttttttc tgccttccgg gtcccatcct   1811

 tagagctcga gtcgttcctt cccctcctgg attccgggta ggagaggcag cgccgcagga   1871

 ggcgggtgcc cgtttgtccc aggcctgggc gtggtggagg aaggggtgct ggaacaataa   1931

 acggcactat ccaaatgtca aaaaaaaaaa aaa                                1964




      <210> 307
      <211> 2200
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (74)..(895)

      <400> 307
 aattcccggg tcgacgatct cgttgcatct ttacttgtgg agctgtggca agtcctcata     60

 tcaaatacag aac   atg atc ttc ctc ctg cta atg gtg agc ctg gaa ttg     109
                  Met Ile Phe Leu Leu Leu Met Val Ser Leu Glu Leu
                    1               5                  10

 cag ctt cac cag ata gca gct tta ttc aca gtg aca gtc cct aag gaa      157
 Gln Leu His Gln Ile Ala Ala Leu Phe Thr Val Thr Val Pro Lys Glu
          15                  20                  25

 ctg tac ata ata gag cat ggc agc aat gtg acc ctg gaa tgc aac ttt      205
 Leu Tyr Ile Ile Glu His Gly Ser Asn Val Thr Leu Glu Cys Asn Phe
      30                  35                  40

 gac act gga agt cat gtg aac ctt gga gca ata aca gcc agt ttg caa      253
 Asp Thr Gly Ser His Val Asn Leu Gly Ala Ile Thr Ala Ser Leu Gln
  45                  50                  55                  60

 aag gtg gaa aat gat aca tcc cca cac cgt gaa aga gcc act ttg ctg      301
 Lys Val Glu Asn Asp Thr Ser Pro His Arg Glu Arg Ala Thr Leu Leu
                  65                  70                  75

 gag gag cag ctg ccc cta ggg aag gcc tcg ttc cac ata cct caa gtc      349
 Glu Glu Gln Leu Pro Leu Gly Lys Ala Ser Phe His Ile Pro Gln Val
              80                  85                  90

 caa gtg agg gac gaa gga cag tac caa tgc ata atc atc tat ggg gtc      397
 Gln Val Arg Asp Glu Gly Gln Tyr Gln Cys Ile Ile Ile Tyr Gly Val
          95                 100                 105

 gcc tgg gac tac aag tac ctg act ctg aaa gtc aaa gct tcc tac agg      445
 Ala Trp Asp Tyr Lys Tyr Leu Thr Leu Lys Val Lys Ala Ser Tyr Arg
     110                 115                 120

 aaa ata aac act cac atc cta aag gtt cca gaa aca gat gag gta gag      493
 Lys Ile Asn Thr His Ile Leu Lys Val Pro Glu Thr Asp Glu Val Glu
 125                 130                 135                 140

 ctc acc tgc cag gct aca ggt tat cct ctg gca gaa gta tcc tgg cca      541
 Leu Thr Cys Gln Ala Thr Gly Tyr Pro Leu Ala Glu Val Ser Trp Pro
                 145                 150                 155

 aac gtc agc gtt cct gcc aac acc agc cac tcc agg acc cct gaa ggc      589
 Asn Val Ser Val Pro Ala Asn Thr Ser His Ser Arg Thr Pro Glu Gly
             160                 165                 170

 ctc tac cag gtc acc agt gtt ctg cgc cta aag cca ccc cct ggc aga      637
 Leu Tyr Gln Val Thr Ser Val Leu Arg Leu Lys Pro Pro Pro Gly Arg
         175                 180                 185

 aac ttc agc tgt gtg ttc tgg aat act cac gtg agg gaa ctt act ttg      685
 Asn Phe Ser Cys Val Phe Trp Asn Thr His Val Arg Glu Leu Thr Leu
     190                 195                 200

 gcc agc att gac ctt caa agt cag atg gaa ccc agg acc cat cca act      733
 Ala Ser Ile Asp Leu Gln Ser Gln Met Glu Pro Arg Thr His Pro Thr
 205                 210                 215                 220

 tgg ctg ctt cac att ttc atc ccc tcc tgc atc att gct ttc att ttc      781
 Trp Leu Leu His Ile Phe Ile Pro Ser Cys Ile Ile Ala Phe Ile Phe
                 225                 230                 235

 ata gcc aca gtg ata gcc cta aga aaa caa ctc tgt caa aag ctg tat      829
 Ile Ala Thr Val Ile Ala Leu Arg Lys Gln Leu Cys Gln Lys Leu Tyr
             240                 245                 250

 tct tca aaa gac aca aca aaa aga cct gtc acc aca aca aag agg gaa      877
 Ser Ser Lys Asp Thr Thr Lys Arg Pro Val Thr Thr Thr Lys Arg Glu
         255                 260                 265

 gtg aac agt gct atc tga acctgt ggtcttggga gccagggtga cctgatatga      931
 Val Asn Ser Ala Ile 
     270

 catctaaaga agcttctgga ctctgaacaa gaattcggtg gcctgcagag cttgccattt    991

 gcacttttca aatgcctttg gatgacccag cactttaatc tgaaacctgc aacaagacta   1051

 gccaacacct ggccatgaaa cttgcccctt cactgatctg gactcacctc tggagcctat   1111

 ggctttaagc aagcactact gcactttaca gaattacccc actggatcct ggacccacag   1171

 aattccttca ggatccttct tgctgccaga ctgaaagcaa aaggaattat ttcccctcaa   1231

 gttttctaag tgatttccaa aagcagaggt gtgtggaaat ttccagtaac agaaacagat   1291

 gggttgccaa tagagttatt ttttatctat agcttcctct gggtactaga agaggctatt   1351

 gagactatga gctcacagac agggcttcgc acaaactcaa atcataattg acatgtttta   1411

 tggattactg gaatcttgat agcataatga agttgttcta attaacagag agcatttaaa   1471

 tatacactaa gtgcacaaat tgtggagtaa agtcatcaag ctctgttttt gaggtctaag   1531

 tcacaaagca tttgttttaa cctgtaatgg caccatgttt aatggtggtt ttttttttga   1591

 actacatctt tcctttaaaa attattggtt tctttttatt tgtttttacc ttagaaatca   1651

 attatataca gtcaaaaata tttgatatgc tcatacgttg tatctgcagc aatttcagat   1711

 aagtagctaa aatggccaaa gccccaaact aagcctcctt ttctggccct caatatgact   1771

 ttaaatttga cttttcagtg cctcagtttg cacatctgta atacagcaat gctaagtagt   1831

 caaggccttt gataattggc actatggaaa tcctgcaaga tcccactaca tatgtgtgga   1891

 gcagaagggt aactcggcta cagtaacagc ttaattttgt taaatttgtt ctttatactg   1951

 gagccatgaa gctcagagca ttagctgacc cttgaactat tcaaatgggc acattagcta   2011

 gtataacaga cttacatagg tgggcctaaa gcaagctcct taactgagca aaatttgggg   2071

 cttatgagaa tgaaagggtg tgaaattgac taacagacaa atcatacatc tcagtttctc   2131

 aattctcatg taaatcagag aatgccttta aagaataaaa ctcaattgtt attcttcaaa   2191

 aaaaaaaaa                                                           2200




      <210> 308
      <211> 1310
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (413)..(673)

      <400> 308
 ttaaatatcc cacattgtga cacattttga gagaattaag cttctgtagt ttcaaacctt     60

 ttatcagata gattaaaata ttataatatt aaagttattc attggtaaat ataattgtta    120

 taaatgataa tgtatatgtt taacaattat caagacagta gctaatagta aatataattc    180

 gtagtaaaat aaatctttct ttttcctctt tattttagtt aagtatgaga gagaagctag    240

 taaatactgg gacacatttt acaagattca taagaataag tttttcaagg atcgtaattg    300

 gctgttgagg gaatttcctg aaattcttcc agttgatcaa aaacctgaag agaaggcgag    360

 agaatcatca tgggatcatg taaaaactag tgctacaaat cgtttctcaa ga    atg     415
                                                              Met
                                                                1

 cac tgt cct act gtg cct gat gaa aaa aat cat tat gag aaa agt tct      463
 His Cys Pro Thr Val Pro Asp Glu Lys Asn His Tyr Glu Lys Ser Ser
               5                  10                  15

 ggt tct tca gaa ggt caa agc aaa aca gaa tct gat ttt tcc aac cta      511
 Gly Ser Ser Glu Gly Gln Ser Lys Thr Glu Ser Asp Phe Ser Asn Leu
          20                  25                  30

 gac tct gaa aaa cac aaa aaa gga cct atg gag act gga ttg ttt cct      559
 Asp Ser Glu Lys His Lys Lys Gly Pro Met Glu Thr Gly Leu Phe Pro
      35                  40                  45

 ggt agc aat gcc act ttc agg ata cta gag gtt ggt tgt gga gct gga      607
 Gly Ser Asn Ala Thr Phe Arg Ile Leu Glu Val Gly Cys Gly Ala Gly
  50                  55                  60                  65

 aat agt gtg ttt cca att ttt gaa cac ttt gga gaa ctc tcc gga gtc      655
 Asn Ser Val Phe Pro Ile Phe Glu His Phe Gly Glu Leu Ser Gly Val
                  70                  75                  80

 ctt tct gta ttg ttg tga ttttgc ttctggagct gtggagctcg taaagtcaca      709
 Leu Ser Val Leu Leu 
              85

 ctcgtcctac agagcaaccc agtgttttgc ctttgttcat gatgtatgtg atgatggctt    769

 accttaccct tttccagatg ggatcctgga tgtcattctc cttgtctttg tgctctcttc    829

 tattcatcct gacaggatgc aaggtgttgt aaaccgactg tccaagttac tgaaacctgg    889

 gggaatgctg ttatttcgag actatggaag atatgataag actcagcttc gttttaaaaa    949

 gggacattgt ttatctgaaa atttttatgt tcgaggagat ggtaccagag catatttctt   1009

 tacaaaaggg gaagtccaca gtatgttctg caaagccagt ttagatgaaa agcaaaatct   1069

 ggttgatcgc cgcttacaag ttaataggaa aaaacaagtg aaaatgcacc gagtgtggat   1129

 tcaaggcaaa ttccagaaac cattgcacca gactcagaat agctccaata tggtatctac   1189

 actcctttca caagactgaa ctttgtaaca tgttaaggta caaagccaga ggactgtgct   1249

 attcaaggac tactgtaagt ctattgtttc tcaaaagaca atgagaaaaa aaaaaaaaaa   1309

 a                                                                   1310




      <210> 309
      <211> 905
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (33)..(632)

      <400> 309
 gaagctcacg ttctgacctg cagttccctg tg  atg aac ttc aag agg gaa ctt      53
                                      Met Asn Phe Lys Arg Glu Leu
                                        1               5

 act ggg gga act cac cac caa tat ttc aac gac cac gct gga cac gca      101
 Thr Gly Gly Thr His His Gln Tyr Phe Asn Asp His Ala Gly His Ala
          10                  15                  20

 gtt cgc gtg cgg ccg ctc ccc gag cag tgc gcg gcg tgg gcg gag gag      149
 Val Arg Val Arg Pro Leu Pro Glu Gln Cys Ala Ala Trp Ala Glu Glu
      25                  30                  35

 cgg ctc cgc gag gag atc gag gca aac gcg gcg ccc gcg ctg ctg gaa      197
 Arg Leu Arg Glu Glu Ile Glu Ala Asn Ala Ala Pro Ala Leu Leu Glu
  40                  45                  50                  55

 atc gtg gac gcg gcg gac gcc gag cac ctg gtc acg ctc cag gac ctg      245
 Ile Val Asp Ala Ala Asp Ala Glu His Leu Val Thr Leu Gln Asp Leu
                  60                  65                  70

 gac atc cgc cac ggc gac ggc ttc gcg gtg ctc cgg ggc gtg tgc agc      293
 Asp Ile Arg His Gly Asp Gly Phe Ala Val Leu Arg Gly Val Cys Ser
              75                  80                  85

 gag gcc tcg ttc ccg gcc gtg agg ccg ctg cgc gag cgc ctg cgc ggg      341
 Glu Ala Ser Phe Pro Ala Val Arg Pro Leu Arg Glu Arg Leu Arg Gly
          90                  95                 100

 ctg tgg gaa ccc ggg gcc gtc ctg ctg gtg ctg gtg ggc acc cag gcc      389
 Leu Trp Glu Pro Gly Ala Val Leu Leu Val Leu Val Gly Thr Gln Ala
     105                 110                 115

 gac cgg gac tcc gag cgc cag gtg ctg atg gcg cgg gcc cgc gag ggg      437
 Asp Arg Asp Ser Glu Arg Gln Val Leu Met Ala Arg Ala Arg Glu Gly
 120                 125                 130                 135

 ccc tgc ccg ttc ccg ggg gtc acg gcc aag atc cag cgg agg atg gac      485
 Pro Cys Pro Phe Pro Gly Val Thr Ala Lys Ile Gln Arg Arg Met Asp
                 140                 145                 150

 cag gtg ttc acg ctg gcg gtg cgc gag acg gag gcc ctg atc ccg ccc      533
 Gln Val Phe Thr Leu Ala Val Arg Glu Thr Glu Ala Leu Ile Pro Pro
             155                 160                 165

 gag ggt gtc cct gac cga gct ggt ctc ggc aag tgg cgc cca aca tgg      581
 Glu Gly Val Pro Asp Arg Ala Gly Leu Gly Lys Trp Arg Pro Thr Trp
         170                 175                 180

 ggg ctc gaa tcc ggg tca aag ggt cgc cgg agc gat ggt tgg aga acg      629
 Gly Leu Glu Ser Gly Ser Lys Gly Arg Arg Ser Asp Gly Trp Arg Thr
     185                 190                 195

 tga aact aaactggagg acacccgagt actcttaaag caatccccgt gagccaggag      686
 


 agcgtatagc acagctcctg attgtgccgt gagagcggac agggcgatgg caggttcgcc    746

 gggtgtgagg cttcacagcg gtccagggac caagtcgaga tggtgaaaac aagaccaaga    806

 ttggaaagcc agcttcagaa gagggaatta cagcaaaaat tgaaccattg acagaagagt    866

 ctagcagtct cagagagaat gttctccagg attctgaag                           905




      <210> 310
      <211> 608
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (83)..(439)

      <400> 310
 ccttcccggg tcgacgattt cgtgaagtag ctcttatggc tggagattgc aggtttatga     60

 ctgatcctat ttgggaagaa ca atg atg gca ggc att cga gct tta ttt atg     112
                          Met Met Ala Gly Ile Arg Ala Leu Phe Met
                            1               5                  10

 tac ttg tgg ctg cag ctg gac tgg gtg agc aga gga gag agt gtg ggg      160
 Tyr Leu Trp Leu Gln Leu Asp Trp Val Ser Arg Gly Glu Ser Val Gly
                  15                  20                  25

 ctg cat ctt cct acc ctg agt gtc cag gag ggt gac aac tct att atc      208
 Leu His Leu Pro Thr Leu Ser Val Gln Glu Gly Asp Asn Ser Ile Ile
              30                  35                  40

 aac tgt gct tat tca aac agc gcc tca gac tac ttc att tgg tac aag      256
 Asn Cys Ala Tyr Ser Asn Ser Ala Ser Asp Tyr Phe Ile Trp Tyr Lys
          45                  50                  55

 caa gaa tct gga aaa ggt cct caa ttc att ata gac att cgt tca aat      304
 Gln Glu Ser Gly Lys Gly Pro Gln Phe Ile Ile Asp Ile Arg Ser Asn
      60                  65                  70

 atg gac aaa agg caa ggc caa aga gtc acc gtt tta ttg aat aag aca      352
 Met Asp Lys Arg Gln Gly Gln Arg Val Thr Val Leu Leu Asn Lys Thr
  75                  80                  85                  90

 gtg aag cat ctc tct ctg caa att gca gct act caa cct gga gac tca      400
 Val Lys His Leu Ser Leu Gln Ile Ala Ala Thr Gln Pro Gly Asp Ser
                  95                 100                 105

 gct gtc tac ttt tgt gca gag atc cct gaa cag aga tga caagatcatc       449
 Ala Val Tyr Phe Cys Ala Glu Ile Pro Glu Gln Arg 
             110                 115

 tttggaaaag ggacacgact tcatattctc cccagcctga gtcaaggtta ttgcaatagc    509

 actaaagact gtgtaacacc aatgcaggca aatcaacctt tggggatggg actacgctca    569

 ctgtgaagcc aaatatccag aagcctgacc ctgccgtgt                           608




      <210> 311
      <211> 801
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (88)..(765)

      <400> 311
 cgaccacgcg tccgctcacg cggtcggcga ccacaatatg cgcgctctct ttttgctgct     60

 ccctaactct cggatacaga cgatacc    atg ggt ttt gga cac ctg aaa agc     111
                                  Met Gly Phe Gly His Leu Lys Ser
                                    1               5

 cct gcc ggc ctc cat gag ctt agc gat tac ctg ggg gac tgg agc tac      159
 Pro Ala Gly Leu His Glu Leu Ser Asp Tyr Leu Gly Asp Trp Ser Tyr
      10                  15                  20

 aaa cag ggg gat gag cca tca cat gct gat gag gca gta ttt gaa gcc      207
 Lys Gln Gly Asp Glu Pro Ser His Ala Asp Glu Ala Val Phe Glu Ala
  25                  30                  35                  40

 gtg tcc agc cca ccg cct gcc gac ttg tgt cat gcc cta cgt tgg tat      255
 Val Ser Ser Pro Pro Pro Ala Asp Leu Cys His Ala Leu Arg Trp Tyr
                  45                  50                  55

 aat cac atc aag tct tac gaa aag gaa aag gcc agc ctg cca gga gtg      303
 Asn His Ile Lys Ser Tyr Glu Lys Glu Lys Ala Ser Leu Pro Gly Val
              60                  65                  70

 aag aaa gct ttg ggc aaa tat ggt cct gcc gat gag gaa gac act aca      351
 Lys Lys Ala Leu Gly Lys Tyr Gly Pro Ala Asp Glu Glu Asp Thr Thr
          75                  80                  85

 aga agt gga gct aca gat agt aag gat gat gat gac att gac ctc ttt      399
 Arg Ser Gly Ala Thr Asp Ser Lys Asp Asp Asp Asp Ile Asp Leu Phe
      90                  95                 100

 gga tct gat gat gag gag gaa agt gag gaa gca aag aag cta cga gaa      447
 Gly Ser Asp Asp Glu Glu Glu Ser Glu Glu Ala Lys Lys Leu Arg Glu
 105                 110                 115                 120

 gaa cgc ctt gca cag tat gag tcc aag aaa gct aaa aag cct gca gtt      495
 Glu Arg Leu Ala Gln Tyr Glu Ser Lys Lys Ala Lys Lys Pro Ala Val
                 125                 130                 135

 gtt gcg aag tct tcc atc cta cta gac gtg aag cct tgg gat gat gag      543
 Val Ala Lys Ser Ser Ile Leu Leu Asp Val Lys Pro Trp Asp Asp Glu
             140                 145                 150

 acg gac atg aca aaa cta gag gag tgt gtc cga agc att caa gca gat      591
 Thr Asp Met Thr Lys Leu Glu Glu Cys Val Arg Ser Ile Gln Ala Asp
         155                 160                 165

 ggc ctg gtg tgg ggc tcc tct aaa ttg gtt cca gtg gga tat gga att      639
 Gly Leu Val Trp Gly Ser Ser Lys Leu Val Pro Val Gly Tyr Gly Ile
     170                 175                 180

 aaa aag ctt caa ata cag tgt gta gtt gaa gat gat aag gtt gga acg      687
 Lys Lys Leu Gln Ile Gln Cys Val Val Glu Asp Asp Lys Val Gly Thr
 185                 190                 195                 200

 gat atg ctg gaa gag caa att act gct ttt gag gac tac gta cag tcc      735
 Asp Met Leu Glu Glu Gln Ile Thr Ala Phe Glu Asp Tyr Val Gln Ser
                 205                 210                 215

 atg gat gtg gct gct ttt aac aag att taa a tcattcttaa gtcagtgcac      786
 Met Asp Val Ala Ala Phe Asn Lys Ile 
             220                 225

 ttaaatgaga gctca                                                     801




      <210> 312
      <211> 2307
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(2180)

      <400> 312
 ggggaaaagg catcaacagc accagcaaat aaagaacaga tgctcaatta gtgatggtga     60

 tggacaagat tcctttattt ttgaagcaaa tgaagcttgg aaagattttc atggttctct    120

 tcttcgattt tatgaaaatg gagaactctg tgatgtcaca ctcaagtcac agcaaactgt    180

 acaatggcag ttgagtgggt tttgaaaaac gtctgaattg tagtgtctac atctaccttc    240

 tgccttctct ctaccctttg aaaaaaaata aatggcatgt ttgagaagag agctctatta    300

 aaagaggaat atcgcat   atg gct tca gat tct atg aat agt aaa caa gct     350
                      Met Ala Ser Asp Ser Met Asn Ser Lys Gln Ala
                        1               5                  10

 ggg aat cac att aca aag ggg aaa agg caa caa cag cac cag caa ata      398
 Gly Asn His Ile Thr Lys Gly Lys Arg Gln Gln Gln His Gln Gln Ile
              15                  20                  25

 aag aac aga tcc tca att agt gat ggt gat gga gaa gat tcc ttt att      446
 Lys Asn Arg Ser Ser Ile Ser Asp Gly Asp Gly Glu Asp Ser Phe Ile
          30                  35                  40

 ttt gaa gca aat gaa gct tgg aaa gat ttt cat ggt tct ctt ctt cga      494
 Phe Glu Ala Asn Glu Ala Trp Lys Asp Phe His Gly Ser Leu Leu Arg
      45                  50                  55

 ttt tat gaa aat gga gaa ctc tgt gat gtc aca ctc aag gtt ggc tca      542
 Phe Tyr Glu Asn Gly Glu Leu Cys Asp Val Thr Leu Lys Val Gly Ser
  60                  65                  70                  75

 aag cta atc tct tgt cac aag ctg gta ttg gct tgt gtt att ccc tac      590
 Lys Leu Ile Ser Cys His Lys Leu Val Leu Ala Cys Val Ile Pro Tyr
                  80                  85                  90

 ttt aga gcc atg ttt ctt tct gaa atg gct gaa gcc aag caa acg ctg      638
 Phe Arg Ala Met Phe Leu Ser Glu Met Ala Glu Ala Lys Gln Thr Leu
              95                 100                 105

 att gag att aga gat ttt gat ggt gat gca ata gaa gac ttg gta aag      686
 Ile Glu Ile Arg Asp Phe Asp Gly Asp Ala Ile Glu Asp Leu Val Lys
         110                 115                 120

 ttt gtc tat tct tca cgg ctc act ttg act gtt gac aat gtc cag cct      734
 Phe Val Tyr Ser Ser Arg Leu Thr Leu Thr Val Asp Asn Val Gln Pro
     125                 130                 135

 ctc tta tat gca gcc tgt att ctg cag gtt gaa ctg gtg gct aga gct      782
 Leu Leu Tyr Ala Ala Cys Ile Leu Gln Val Glu Leu Val Ala Arg Ala
 140                 145                 150                 155

 tgt tgt gaa tac atg aag tta cat ttt cat ccc tcc aat tgc ctg gca      830
 Cys Cys Glu Tyr Met Lys Leu His Phe His Pro Ser Asn Cys Leu Ala
                 160                 165                 170

 gta aga gcc ttt gca gaa agt cac aat cga ata gac tta atg gac atg      878
 Val Arg Ala Phe Ala Glu Ser His Asn Arg Ile Asp Leu Met Asp Met
             175                 180                 185

 gcg gat cag tat gcc tgt gac cat ttt act gaa gta gtg gag ggt gaa      926
 Ala Asp Gln Tyr Ala Cys Asp His Phe Thr Glu Val Val Glu Gly Glu
         190                 195                 200

 gac ttt gta agt gta tca ccg cag cac ctc cat aag ctt ttg tcc tcc      974
 Asp Phe Val Ser Val Ser Pro Gln His Leu His Lys Leu Leu Ser Ser
     205                 210                 215

 agt gat cta aat att gaa aat gaa aag cag gtc tat aat gct gcc atc     1022
 Ser Asp Leu Asn Ile Glu Asn Glu Lys Gln Val Tyr Asn Ala Ala Ile
 220                 225                 230                 235

 aag tgg ctt ctt gcc aat cct cag cat cat tcc aaa tgg ttg gat gaa     1070
 Lys Trp Leu Leu Ala Asn Pro Gln His His Ser Lys Trp Leu Asp Glu
                 240                 245                 250

 aca ctt gca cag gtt cgc ctg cca ttg ttg ccg gtt gat ttt ctt atg     1118
 Thr Leu Ala Gln Val Arg Leu Pro Leu Leu Pro Val Asp Phe Leu Met
             255                 260                 265

 ggt gtt gtg gca aaa gaa cag att gtc aag caa aat cta aaa tgt aga     1166
 Gly Val Val Ala Lys Glu Gln Ile Val Lys Gln Asn Leu Lys Cys Arg
         270                 275                 280

 gat tta ctg gat gaa gca aga aat tac cac ctt cac ttg agt agc aga     1214
 Asp Leu Leu Asp Glu Ala Arg Asn Tyr His Leu His Leu Ser Ser Arg
     285                 290                 295

 gca gta cct gac ttt gaa tac tcc att cgg act acc cca agg aag cat     1262
 Ala Val Pro Asp Phe Glu Tyr Ser Ile Arg Thr Thr Pro Arg Lys His
 300                 305                 310                 315

 act gct ggt gtg ctg ttt tgt gta ggt ggt cga ggt gga tct ggt gac     1310
 Thr Ala Gly Val Leu Phe Cys Val Gly Gly Arg Gly Gly Ser Gly Asp
                 320                 325                 330

 ccc ttt cgc agt att gaa tgc tat tct atc aac aaa aac agt tgg ttc     1358
 Pro Phe Arg Ser Ile Glu Cys Tyr Ser Ile Asn Lys Asn Ser Trp Phe
             335                 340                 345

 ttt gga cca gaa atg aat agt cga agg cga cat gtg ggt gta atc tct     1406
 Phe Gly Pro Glu Met Asn Ser Arg Arg Arg His Val Gly Val Ile Ser
         350                 355                 360

 gtg gaa ggt aaa gtg tat gca gta ggt gga cat gat gga aat gaa cat     1454
 Val Glu Gly Lys Val Tyr Ala Val Gly Gly His Asp Gly Asn Glu His
     365                 370                 375

 tta ggg agt atg gag atg ttt gat cct ctc act aat aaa tgg atg atg     1502
 Leu Gly Ser Met Glu Met Phe Asp Pro Leu Thr Asn Lys Trp Met Met
 380                 385                 390                 395

 aag gca tca atg aac aca aag agg cga gga att gcc ttg gct tcc tta     1550
 Lys Ala Ser Met Asn Thr Lys Arg Arg Gly Ile Ala Leu Ala Ser Leu
                 400                 405                 410

 gga ggc cca att tat gca att gga ggg tta gat gac aat act tgc ttc     1598
 Gly Gly Pro Ile Tyr Ala Ile Gly Gly Leu Asp Asp Asn Thr Cys Phe
             415                 420                 425

 aat gat gtg gag aga tat gac ata gaa tct gat cag tgg agt aca gtg     1646
 Asn Asp Val Glu Arg Tyr Asp Ile Glu Ser Asp Gln Trp Ser Thr Val
         430                 435                 440

 gca cca atg aat act ccc cgt gga gga gtt ggc tct gtt gct cta gta     1694
 Ala Pro Met Asn Thr Pro Arg Gly Gly Val Gly Ser Val Ala Leu Val
     445                 450                 455

 aac cat gtt tat gca gta ggt ggc aat gat gga atg gct tct tta tct     1742
 Asn His Val Tyr Ala Val Gly Gly Asn Asp Gly Met Ala Ser Leu Ser
 460                 465                 470                 475

 agc gtg gag aga tat gat cca cat ctg gat aag tgg ata gaa gtt aaa     1790
 Ser Val Glu Arg Tyr Asp Pro His Leu Asp Lys Trp Ile Glu Val Lys
                 480                 485                 490

 gaa atg ggt cag cga aga gca ggc aat gga gtt agc aag ctt cat ggt     1838
 Glu Met Gly Gln Arg Arg Ala Gly Asn Gly Val Ser Lys Leu His Gly
             495                 500                 505

 tgc tta tac gta gtt ggt ggt ttt gat gat aat tct cct ctg agt tca     1886
 Cys Leu Tyr Val Val Gly Gly Phe Asp Asp Asn Ser Pro Leu Ser Ser
         510                 515                 520

 gtt gag cgg tat gac ccc cga agc aac aag tgg gat tat gtg gca gca     1934
 Val Glu Arg Tyr Asp Pro Arg Ser Asn Lys Trp Asp Tyr Val Ala Ala
     525                 530                 535

 ctt act act ccc aga ggt gga gtg gga atc gca aca gtg atg ggc aaa     1982
 Leu Thr Thr Pro Arg Gly Gly Val Gly Ile Ala Thr Val Met Gly Lys
 540                 545                 550                 555

 atc ttt gca gtt ggt ggt cat aat ggc aat gca tac tta aat aca gta     2030
 Ile Phe Ala Val Gly Gly His Asn Gly Asn Ala Tyr Leu Asn Thr Val
                 560                 565                 570

 gaa gcg ttt gat cca gtg ctg aat agg tgg gag ctt gtt gga tct gtg     2078
 Glu Ala Phe Asp Pro Val Leu Asn Arg Trp Glu Leu Val Gly Ser Val
             575                 580                 585

 tct cac tgc aga gct gga gca gga gta gct gtg tgt tcc tgt tta act     2126
 Ser His Cys Arg Ala Gly Ala Gly Val Ala Val Cys Ser Cys Leu Thr
         590                 595                 600

 agc caa att cga gat gta ggt cat gga tcc aat aat gtg gtt gac tgt     2174
 Ser Gln Ile Arg Asp Val Gly His Gly Ser Asn Asn Val Val Asp Cys
     605                 610                 615

 atg tga tttgagttct ggccaccaac aatttagtca tatctgatag gtacaaaaga      2230
 Met 
 620

 aaaccaagat tttgatatga ccacctttca acacttttta ctgcaactag agtcttattt   2290

 aaatgttaac tgtgtat                                                  2307




      <210> 313
      <211> 1811
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (192)..(1652)

      <400> 313
 cggacgcgtg ggctctccgt cagtgcggtt tcgtctttat ggtggtggag tccgcccagg     60

 ctgtggaccg caaataaccc tgtacaaaga ggaatggaga ttgcctctat ccacctagat    120

 tcataagctg gcctgaggtg atcttggcat caaggaaggg atgcacatca tcacaccatc    180

 agcttcagag a atg gca gcc att tat ttg tcc cgt ggg ttt ttt tcc agg     230
              Met Ala Ala Ile Tyr Leu Ser Arg Gly Phe Phe Ser Arg
                1               5                  10

 gaa cca atc tgc cct ttt gaa gaa aag aca aag gta gaa agg atg gtg      278
 Glu Pro Ile Cys Pro Phe Glu Glu Lys Thr Lys Val Glu Arg Met Val
      15                  20                  25

 gag gac tac ctg gca agt ggt tat cag gat tca gtg acg ttt gat gat      326
 Glu Asp Tyr Leu Ala Ser Gly Tyr Gln Asp Ser Val Thr Phe Asp Asp
  30                  35                  40                  45

 gtg gct gtg gac ttc acc cca gag gag tgg gct tta ctg gac aca act      374
 Val Ala Val Asp Phe Thr Pro Glu Glu Trp Ala Leu Leu Asp Thr Thr
                  50                  55                  60

 gag aaa tac ctc tac aga gat gtg atg ctg gag aac tac atg aac ctg      422
 Glu Lys Tyr Leu Tyr Arg Asp Val Met Leu Glu Asn Tyr Met Asn Leu
              65                  70                  75

 gcc tct gtg gaa tgg gaa ata caa cct aga acc aaa cgg tca tca ctt      470
 Ala Ser Val Glu Trp Glu Ile Gln Pro Arg Thr Lys Arg Ser Ser Leu
          80                  85                  90

 cag cag ggt ttt ttg aag aat caa ata ttc agt ggg ata caa atg aca      518
 Gln Gln Gly Phe Leu Lys Asn Gln Ile Phe Ser Gly Ile Gln Met Thr
      95                 100                 105

 aga gac tac agt gga tgg aaa ctc tgt gac tgt aag aat tgt gga gag      566
 Arg Asp Tyr Ser Gly Trp Lys Leu Cys Asp Cys Lys Asn Cys Gly Glu
 110                 115                 120                 125

 gtc ttc agg gaa cag ttt tgc ctt aag aca cac atg aga gtt cag aat      614
 Val Phe Arg Glu Gln Phe Cys Leu Lys Thr His Met Arg Val Gln Asn
                 130                 135                 140

 gga ggg aat act tct gag ggt aat tgt tat gga aaa gac acc ctc agt      662
 Gly Gly Asn Thr Ser Glu Gly Asn Cys Tyr Gly Lys Asp Thr Leu Ser
             145                 150                 155

 gtg cac aag gaa gcc tct act gga cag gaa ctt tcc aaa ttt aat cca      710
 Val His Lys Glu Ala Ser Thr Gly Gln Glu Leu Ser Lys Phe Asn Pro
         160                 165                 170

 tgt gga aaa gtc ttt act cta act cca ggt ctt gct gta cat ctt gaa      758
 Cys Gly Lys Val Phe Thr Leu Thr Pro Gly Leu Ala Val His Leu Glu
     175                 180                 185

 gtt ctc aat gca aga caa ccc tac aaa tgt aag gaa tgt gga aaa ggc      806
 Val Leu Asn Ala Arg Gln Pro Tyr Lys Cys Lys Glu Cys Gly Lys Gly
 190                 195                 200                 205

 ttt aag tat ttt gca agc ctt gat aat cat atg gga atc cac act gat      854
 Phe Lys Tyr Phe Ala Ser Leu Asp Asn His Met Gly Ile His Thr Asp
                 210                 215                 220

 gag aaa ctc tgt gaa ttt cag gaa tat ggg aga gct gtc aca gct tct      902
 Glu Lys Leu Cys Glu Phe Gln Glu Tyr Gly Arg Ala Val Thr Ala Ser
             225                 230                 235

 tca cac cta aag cag tgt gta gca gtt cat aca gga aag aaa tcc aaa      950
 Ser His Leu Lys Gln Cys Val Ala Val His Thr Gly Lys Lys Ser Lys
         240                 245                 250

 aag act aag aaa tgt ggg aaa tcc ttc act aat ttt tct caa ctt tat      998
 Lys Thr Lys Lys Cys Gly Lys Ser Phe Thr Asn Phe Ser Gln Leu Tyr
     255                 260                 265

 gca cct gtg aaa act cat aaa gga gag aag tcc ttt gaa tgt aaa gaa     1046
 Ala Pro Val Lys Thr His Lys Gly Glu Lys Ser Phe Glu Cys Lys Glu
 270                 275                 280                 285

 tgt gga aga tcc ttt aga aat tcc tca tgc ctt aat gat cac att caa     1094
 Cys Gly Arg Ser Phe Arg Asn Ser Ser Cys Leu Asn Asp His Ile Gln
                 290                 295                 300

 att cac act gga ata aaa cca cac aag tgt act tac tgt ggg aaa gcc     1142
 Ile His Thr Gly Ile Lys Pro His Lys Cys Thr Tyr Cys Gly Lys Ala
             305                 310                 315

 ttc act aga tca act caa ctt act gaa cat gta aga act cac act gga     1190
 Phe Thr Arg Ser Thr Gln Leu Thr Glu His Val Arg Thr His Thr Gly
         320                 325                 330

 ata aaa ccc tat gaa tgt aag gaa tgt ggc caa gcc ttt gct cag tac     1238
 Ile Lys Pro Tyr Glu Cys Lys Glu Cys Gly Gln Ala Phe Ala Gln Tyr
     335                 340                 345

 tcg ggc ctt tct ata cac ata cga agt cac agt gga aag aaa ccc tat     1286
 Ser Gly Leu Ser Ile His Ile Arg Ser His Ser Gly Lys Lys Pro Tyr
 350                 355                 360                 365

 cag tgt aag gaa tgt ggg aaa gcc ttc act aca tcc aca agt ctt att     1334
 Gln Cys Lys Glu Cys Gly Lys Ala Phe Thr Thr Ser Thr Ser Leu Ile
                 370                 375                 380

 cag cat aca aga att cac aca gga gag aag cct tat gaa tgt gtt gaa     1382
 Gln His Thr Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Val Glu
             385                 390                 395

 tgt ggg aag acc ttc att act tct tcc cgt cgt agt aaa cat ttg aaa     1430
 Cys Gly Lys Thr Phe Ile Thr Ser Ser Arg Arg Ser Lys His Leu Lys
         400                 405                 410

 act cat agt gga gaa aag ccc ttt gta tgc aag ata tgt ggg aaa gca     1478
 Thr His Ser Gly Glu Lys Pro Phe Val Cys Lys Ile Cys Gly Lys Ala
     415                 420                 425

 ttt cta tat tcc tca cgc ctt aat gtt cac ctg cga act cat acc gga     1526
 Phe Leu Tyr Ser Ser Arg Leu Asn Val His Leu Arg Thr His Thr Gly
 430                 435                 440                 445

 gag aaa ccc ttc gta tgt aaa gaa tgt ggg aaa gca ttt gct gtt tcc     1574
 Glu Lys Pro Phe Val Cys Lys Glu Cys Gly Lys Ala Phe Ala Val Ser
                 450                 455                 460

 tca cgc cta agt aga cat gaa aga att cac act ggg gag aaa ccc tat     1622
 Ser Arg Leu Ser Arg His Glu Arg Ile His Thr Gly Glu Lys Pro Tyr
             465                 470                 475

 gaa tgc aag gat atg agt gtt acc att tag c ccatcggttg ccatctttaa     1673
 Glu Cys Lys Asp Met Ser Val Thr Ile 
         480                 485

 ttattggcaa tgacaccaaa gattatcaga tttgtcctaa atgccttttg gaggttgtaa   1733

 tgactcatgg attggcctta gataccatcc tgagggtctg aaattaaacc tacaggttct   1793

 gaatacaaaa aaaaaaaa                                                 1811




      <210> 314
      <211> 3185
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(3131)

      <400> 314
 cccatgggct gtgttacata gagacagcag aacttgatgg cgagaccaac   atg aaa      56
                                                          Met Lys
                                                            1

 gta cgt cag gcg att cca gtc acc tca gaa ttg gga gac atc agt aag      104
 Val Arg Gln Ala Ile Pro Val Thr Ser Glu Leu Gly Asp Ile Ser Lys
           5                  10                  15

 ctt gcc aag ttt gac ggt gaa gtg atc tgt gaa cct ccc aac aac aaa      152
 Leu Ala Lys Phe Asp Gly Glu Val Ile Cys Glu Pro Pro Asn Asn Lys
      20                  25                  30

 ctg gac aaa ttc agc gga acc ctc tac tgg aag gaa aat aag ttc cct      200
 Leu Asp Lys Phe Ser Gly Thr Leu Tyr Trp Lys Glu Asn Lys Phe Pro
  35                  40                  45                  50

 ctg agc aac cag aac atg ctg ctg cgg ggc tgt gtg ctg cga aac acc      248
 Leu Ser Asn Gln Asn Met Leu Leu Arg Gly Cys Val Leu Arg Asn Thr
                  55                  60                  65

 gag tgg tgc ttc ggg ctg gtc atc ttt gca ggt ccc gac act aag ctg      296
 Glu Trp Cys Phe Gly Leu Val Ile Phe Ala Gly Pro Asp Thr Lys Leu
              70                  75                  80

 atg caa aac agc ggc aga aca aag ttc aaa aga acg agt atc gat cgc      344
 Met Gln Asn Ser Gly Arg Thr Lys Phe Lys Arg Thr Ser Ile Asp Arg
          85                  90                  95

 cta atg aat acc ctg gtg ctc tgg att ttt gga ttc ctg gtt tgc atg      392
 Leu Met Asn Thr Leu Val Leu Trp Ile Phe Gly Phe Leu Val Cys Met
     100                 105                 110

 ggg gtg atc ctg gcc att ggc aat gcc atc tgg gag cac gag gtg ggg      440
 Gly Val Ile Leu Ala Ile Gly Asn Ala Ile Trp Glu His Glu Val Gly
 115                 120                 125                 130

 atg cgt ttc cag gtc tac ctg ccg tgg gat gag gca gtg gac agt gcc      488
 Met Arg Phe Gln Val Tyr Leu Pro Trp Asp Glu Ala Val Asp Ser Ala
                 135                 140                 145

 ttc ttc tct ggc ttc ctc tcc ttc tgg tcc tac atc atc atc ctc aac      536
 Phe Phe Ser Gly Phe Leu Ser Phe Trp Ser Tyr Ile Ile Ile Leu Asn
             150                 155                 160

 acc gtt gtg ccc att tca ctc tat gtc agt gtg gag gtc atc cgt ctg      584
 Thr Val Val Pro Ile Ser Leu Tyr Val Ser Val Glu Val Ile Arg Leu
         165                 170                 175

 ggc cac agc tac ttc atc aac tgg gat aag aag atg ttc tgc atg aag      632
 Gly His Ser Tyr Phe Ile Asn Trp Asp Lys Lys Met Phe Cys Met Lys
     180                 185                 190

 aag cgg acg cct gca gaa gcc cgc acc acc acc cta aac gag gag ctg      680
 Lys Arg Thr Pro Ala Glu Ala Arg Thr Thr Thr Leu Asn Glu Glu Leu
 195                 200                 205                 210

 ggc cag gtg gag tac atc ttc tcc gac aag acg ggc acc ctc acc cag      728
 Gly Gln Val Glu Tyr Ile Phe Ser Asp Lys Thr Gly Thr Leu Thr Gln
                 215                 220                 225

 aac atc atg gtt ttc aac aag tgc tcc atc aat ggc cac agc tat ggt      776
 Asn Ile Met Val Phe Asn Lys Cys Ser Ile Asn Gly His Ser Tyr Gly
             230                 235                 240

 gat gtg ttt gac gtc ctg gga cac aaa gct gaa ttg gga gag agg cct      824
 Asp Val Phe Asp Val Leu Gly His Lys Ala Glu Leu Gly Glu Arg Pro
         245                 250                 255

 gaa cct gtt gac ttc tcc ttc aat cct ctg gct gac aag aag ttc tta      872
 Glu Pro Val Asp Phe Ser Phe Asn Pro Leu Ala Asp Lys Lys Phe Leu
     260                 265                 270

 ttt tgg gac ccc agc ctg ctg gag gct gtc aag atc ggg gac ccc cac      920
 Phe Trp Asp Pro Ser Leu Leu Glu Ala Val Lys Ile Gly Asp Pro His
 275                 280                 285                 290

 acg cat gag ttc ttc cgc ctc ctt tcc ctg tgt cat act gtc atg tca      968
 Thr His Glu Phe Phe Arg Leu Leu Ser Leu Cys His Thr Val Met Ser
                 295                 300                 305

 gaa gaa aag aac gaa gga gag ctg tac tac aaa gct cag tcc cca gat     1016
 Glu Glu Lys Asn Glu Gly Glu Leu Tyr Tyr Lys Ala Gln Ser Pro Asp
             310                 315                 320

 gag ggg gcc ctg gtc acc gca gcc agg aac ttt ggt ttt gtt ttc cgc     1064
 Glu Gly Ala Leu Val Thr Ala Ala Arg Asn Phe Gly Phe Val Phe Arg
         325                 330                 335

 tct cgc acc ccc aaa aca atc acc gtc cat gag atg ggc aca gcc atc     1112
 Ser Arg Thr Pro Lys Thr Ile Thr Val His Glu Met Gly Thr Ala Ile
     340                 345                 350

 acc tac cag ctg ctg gcc atc ctg gac ttc aac aac atc cgc aag cgg     1160
 Thr Tyr Gln Leu Leu Ala Ile Leu Asp Phe Asn Asn Ile Arg Lys Arg
 355                 360                 365                 370

 atg tcg gtc ata gtg cgg aat cca gag ggg aag atc cga ctc tac tgc     1208
 Met Ser Val Ile Val Arg Asn Pro Glu Gly Lys Ile Arg Leu Tyr Cys
                 375                 380                 385

 aaa ggg gct gac act atc cta ctg gac aga ctg cac cac tcc act caa     1256
 Lys Gly Ala Asp Thr Ile Leu Leu Asp Arg Leu His His Ser Thr Gln
             390                 395                 400

 gag ctg ctc aac acc acc atg gac cac ctt aat gtg ggt gag tac gca     1304
 Glu Leu Leu Asn Thr Thr Met Asp His Leu Asn Val Gly Glu Tyr Ala
         405                 410                 415

 ggg gaa ggg ctg agg acc ctg gtg ctg gcc tac aag gat ctg gat gaa     1352
 Gly Glu Gly Leu Arg Thr Leu Val Leu Ala Tyr Lys Asp Leu Asp Glu
     420                 425                 430

 gag tac tac gag gag tgg gct gag cga cgc ctc cag gcc agc ctg gcc     1400
 Glu Tyr Tyr Glu Glu Trp Ala Glu Arg Arg Leu Gln Ala Ser Leu Ala
 435                 440                 445                 450

 cag gac agc cgg gag gac agg ctg gct agc atc tat gag gag gtt gag     1448
 Gln Asp Ser Arg Glu Asp Arg Leu Ala Ser Ile Tyr Glu Glu Val Glu
                 455                 460                 465

 aac aac atg atg gaa tcc ttg tgg tat ttt cag ctg ctg ggt gca acg     1496
 Asn Asn Met Met Glu Ser Leu Trp Tyr Phe Gln Leu Leu Gly Ala Thr
             470                 475                 480

 gcc att gag gac aaa ctt cag caa ggg gtt cca gag acc att gcc ctc     1544
 Ala Ile Glu Asp Lys Leu Gln Gln Gly Val Pro Glu Thr Ile Ala Leu
         485                 490                 495

 ctg aca ctg gcc aac atc aag att tgg gtg cta acc gga gac aag caa     1592
 Leu Thr Leu Ala Asn Ile Lys Ile Trp Val Leu Thr Gly Asp Lys Gln
     500                 505                 510

 gag acg gct gtg aac atc ggc tat tcc tgc aag atg ctg acg gat gac     1640
 Glu Thr Ala Val Asn Ile Gly Tyr Ser Cys Lys Met Leu Thr Asp Asp
 515                 520                 525                 530

 atg act gag gtt ttc ata gtc act ggc cat act gtc ctg gag gtg cgg     1688
 Met Thr Glu Val Phe Ile Val Thr Gly His Thr Val Leu Glu Val Arg
                 535                 540                 545

 gag gag ctc agg aaa gcc cgg gag aag atg atg gac tca tcc cgc tct     1736
 Glu Glu Leu Arg Lys Ala Arg Glu Lys Met Met Asp Ser Ser Arg Ser
             550                 555                 560

 gta ggc aac ggc ttc acc tat cag gac aag ctt tct tct tcc aag cta     1784
 Val Gly Asn Gly Phe Thr Tyr Gln Asp Lys Leu Ser Ser Ser Lys Leu
         565                 570                 575

 act tct gtc ctg gag gcc gtt gct ggg gag tac gcc ctg gtc ata aat     1832
 Thr Ser Val Leu Glu Ala Val Ala Gly Glu Tyr Ala Leu Val Ile Asn
     580                 585                 590

 ggt cac agc ctg gcc cac gca ctg gag gca gac atg gag ctg gag ttt     1880
 Gly His Ser Leu Ala His Ala Leu Glu Ala Asp Met Glu Leu Glu Phe
 595                 600                 605                 610

 ctg gag aca gcg tgt gcc tgc aaa gct gtc atc tgc tgc cgg gtg acc     1928
 Leu Glu Thr Ala Cys Ala Cys Lys Ala Val Ile Cys Cys Arg Val Thr
                 615                 620                 625

 ccc ttg cag aag gca cag gtg gta gaa ctg gtc aag aag tac aag aag     1976
 Pro Leu Gln Lys Ala Gln Val Val Glu Leu Val Lys Lys Tyr Lys Lys
             630                 635                 640

 gct gtg acg ctt gcc att gga gac gga gcc aat gat gtc agc atg atc     2024
 Ala Val Thr Leu Ala Ile Gly Asp Gly Ala Asn Asp Val Ser Met Ile
         645                 650                 655

 aaa acg gct cac att ggt gtg ggg atc agt ggg cag gaa ggg atc cag     2072
 Lys Thr Ala His Ile Gly Val Gly Ile Ser Gly Gln Glu Gly Ile Gln
     660                 665                 670

 gct gtc ttg gcc tcc gat tac tcc ttc tcc cag ttc aag ttc ctg cag     2120
 Ala Val Leu Ala Ser Asp Tyr Ser Phe Ser Gln Phe Lys Phe Leu Gln
 675                 680                 685                 690

 cgc ctc ctg ctg gtg cat ggg cgc tgg tcc tac ctg cga atg tgc aag     2168
 Arg Leu Leu Leu Val His Gly Arg Trp Ser Tyr Leu Arg Met Cys Lys
                 695                 700                 705

 ttt ctt tgc tat ttc ttc tac aaa aac ttt gct ttc acc atg gtc cac     2216
 Phe Leu Cys Tyr Phe Phe Tyr Lys Asn Phe Ala Phe Thr Met Val His
             710                 715                 720

 ttc tgg ttt ggc ttc ttc tgt ggc ttc tca gcc cag acc gtc tat gac     2264
 Phe Trp Phe Gly Phe Phe Cys Gly Phe Ser Ala Gln Thr Val Tyr Asp
         725                 730                 735

 cag tat ttc atc acc ctg tat aac atc gtg tac acc tcc ctg cca gtc     2312
 Gln Tyr Phe Ile Thr Leu Tyr Asn Ile Val Tyr Thr Ser Leu Pro Val
     740                 745                 750

 ctg gct atg ggg gtc ttt gat cag gat gtc ccc gag cag cgg agc atg     2360
 Leu Ala Met Gly Val Phe Asp Gln Asp Val Pro Glu Gln Arg Ser Met
 755                 760                 765                 770

 gag tac cct aag ctg tat gag ccg ggc cag ctg aac ctt ctc ttc aac     2408
 Glu Tyr Pro Lys Leu Tyr Glu Pro Gly Gln Leu Asn Leu Leu Phe Asn
                 775                 780                 785

 aag cgg gag ttc ttc atc tgc atc gcc cag ggc atc tac acc tcc gtg     2456
 Lys Arg Glu Phe Phe Ile Cys Ile Ala Gln Gly Ile Tyr Thr Ser Val
             790                 795                 800

 ctc atg ttc ttc att ccc tat ggg ggg ttt gct gat gcc acc cgg gat     2504
 Leu Met Phe Phe Ile Pro Tyr Gly Gly Phe Ala Asp Ala Thr Arg Asp
         805                 810                 815

 gat ggc act cag ctg gct gac tac cag tcc ttt gca gtc act gtg gcc     2552
 Asp Gly Thr Gln Leu Ala Asp Tyr Gln Ser Phe Ala Val Thr Val Ala
     820                 825                 830

 aca tcc ttg gtc att gtg gtt agc gtg cag att ggg ctc gac aca ggc     2600
 Thr Ser Leu Val Ile Val Val Ser Val Gln Ile Gly Leu Asp Thr Gly
 835                 840                 845                 850

 tac tgg acg gcc atc aac cac ttc ttc atc tgg gga agc ctt gct gtt     2648
 Tyr Trp Thr Ala Ile Asn His Phe Phe Ile Trp Gly Ser Leu Ala Val
                 855                 860                 865

 tac ttt gcc atc ctc ttt gcc atg cac agc aat ggg ctc ttc gac atg     2696
 Tyr Phe Ala Ile Leu Phe Ala Met His Ser Asn Gly Leu Phe Asp Met
             870                 875                 880

 ttt ccc aac cag ttc cgg ttt gtg ggg aat gcc cag aac acc ttg gcc     2744
 Phe Pro Asn Gln Phe Arg Phe Val Gly Asn Ala Gln Asn Thr Leu Ala
         885                 890                 895

 cag ccc acg gtg tgg ctg acc att gtg ctc acc aca gtc gtc tgc atc     2792
 Gln Pro Thr Val Trp Leu Thr Ile Val Leu Thr Thr Val Val Cys Ile
     900                 905                 910

 atg ccc gtg gtt gcc ttc cga ttc ctc agg ctc aac ctg aag ccg gat     2840
 Met Pro Val Val Ala Phe Arg Phe Leu Arg Leu Asn Leu Lys Pro Asp
 915                 920                 925                 930

 ctc tcc gac acg gtc cgc tac aca cag ctc gtg agg aag aag cag aag     2888
 Leu Ser Asp Thr Val Arg Tyr Thr Gln Leu Val Arg Lys Lys Gln Lys
                 935                 940                 945

 gcc cag cac cgc tgc atg cgg cgg gtt ggc cgc act ggc tcc cgg cgc     2936
 Ala Gln His Arg Cys Met Arg Arg Val Gly Arg Thr Gly Ser Arg Arg
             950                 955                 960

 tcc ggc tat gcc ttc tcc cat cag gag ggc ttc ggg gag ctc atc atg     2984
 Ser Gly Tyr Ala Phe Ser His Gln Glu Gly Phe Gly Glu Leu Ile Met
         965                 970                 975

 tct ggc aag aac atg cgg ctg agc tct ctc gcg ctc tcc agc ttc acc     3032
 Ser Gly Lys Asn Met Arg Leu Ser Ser Leu Ala Leu Ser Ser Phe Thr
     980                 985                 990

 acc cgc tcc agc tcc agc tgg att gag agc ctg cgc agg aag aag agt     3080
 Thr Arg Ser Ser Ser Ser Trp Ile Glu Ser Leu Arg Arg Lys Lys Ser
 995                1000                1005                1010

 gac agt gcc agt agc ccc agt ggc ggt gcc gac aag ccc ctc aag ggc     3128
 Asp Ser Ala Ser Ser Pro Ser Gly Gly Ala Asp Lys Pro Leu Lys Gly
                1015                1020                1025

 tga aggc cgaggatgga tgccctgtgc cagtgaccag agcacccagg gctggccagt     3185
 






      <210> 315
      <211> 2217
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (18)..(2174)

      <400> 315
 tttcgtgcgg gtacctg   atg gcc aca gat ggc tct agg agg ccg agc gtc      50
                      Met Ala Thr Asp Gly Ser Arg Arg Pro Ser Val
                        1               5                  10

 cac aaa gca gtg gaa atc gag cag gag cgg gtg aag tca gcg ggg gcc       98
 His Lys Ala Val Glu Ile Glu Gln Glu Arg Val Lys Ser Ala Gly Ala
              15                  20                  25

 tgg atc atc cac ccc tac agc gac ttc cgg ttt tac tgg gac ctg atc      146
 Trp Ile Ile His Pro Tyr Ser Asp Phe Arg Phe Tyr Trp Asp Leu Ile
          30                  35                  40

 atg ctg ctg ctg atg gtg ggg aac ctc atc gtc ctg cct gtg ggc atc      194
 Met Leu Leu Leu Met Val Gly Asn Leu Ile Val Leu Pro Val Gly Ile
      45                  50                  55

 acc ttc ttc aag gag gag aac tcc ccg cct tgg atc gtc ttc aac gta      242
 Thr Phe Phe Lys Glu Glu Asn Ser Pro Pro Trp Ile Val Phe Asn Val
  60                  65                  70                  75

 ttg tct gat act ttc ttc cta ctg gat ctg gtg ctc aac ttc cga acg      290
 Leu Ser Asp Thr Phe Phe Leu Leu Asp Leu Val Leu Asn Phe Arg Thr
                  80                  85                  90

 ggc atc gtg gtg gag gag ggt gct gag atc ctg ctg gca ccg cgg gcc      338
 Gly Ile Val Val Glu Glu Gly Ala Glu Ile Leu Leu Ala Pro Arg Ala
              95                 100                 105

 atc cgc acg cgc tac ctg cgc acc tgg ttc ctg gtt gac ctc atc tct      386
 Ile Arg Thr Arg Tyr Leu Arg Thr Trp Phe Leu Val Asp Leu Ile Ser
         110                 115                 120

 tct atc cct gtg gat tac acc ttc cta gtg gtg gag ctg gag cca cgg      434
 Ser Ile Pro Val Asp Tyr Thr Phe Leu Val Val Glu Leu Glu Pro Arg
     125                 130                 135

 ttg gac gct gag gtc tac aaa acg gca cgg gcc cta cgc atc gtt cgc      482
 Leu Asp Ala Glu Val Tyr Lys Thr Ala Arg Ala Leu Arg Ile Val Arg
 140                 145                 150                 155

 ttc acc aag atc cta agc ctg ctg agg ctg ctc cgc ctc tcc cgc ctc      530
 Phe Thr Lys Ile Leu Ser Leu Leu Arg Leu Leu Arg Leu Ser Arg Leu
                 160                 165                 170

 atc cgc tac ata cac cag tgg gag gag atc ttt cac atg acc tat gac      578
 Ile Arg Tyr Ile His Gln Trp Glu Glu Ile Phe His Met Thr Tyr Asp
             175                 180                 185

 ctg gcc agt gct gtg gtt cgc atc ttc aac ctc att ggg atg atg ctg      626
 Leu Ala Ser Ala Val Val Arg Ile Phe Asn Leu Ile Gly Met Met Leu
         190                 195                 200

 ctg cta tgt cac tgg gat ggc tgt ctg cag ttc ctg gtg ccc atg ctg      674
 Leu Leu Cys His Trp Asp Gly Cys Leu Gln Phe Leu Val Pro Met Leu
     205                 210                 215

 cag gac ttc cct ccc gac tgc tgg gtc tcc atc aac cac atg gtg aac      722
 Gln Asp Phe Pro Pro Asp Cys Trp Val Ser Ile Asn His Met Val Asn
 220                 225                 230                 235

 cac tcg tgg ggc cgc cag tat tcc cat gcc ctg ttc aag gcc atg agc      770
 His Ser Trp Gly Arg Gln Tyr Ser His Ala Leu Phe Lys Ala Met Ser
                 240                 245                 250

 cac atg ctg tgc att ggc tat ggg cag cag gca cct gta ggc atg ccc      818
 His Met Leu Cys Ile Gly Tyr Gly Gln Gln Ala Pro Val Gly Met Pro
             255                 260                 265

 gac gtc tgg ctc acc atg ctc agc atg atc gta ggt gcc aca tgc tac      866
 Asp Val Trp Leu Thr Met Leu Ser Met Ile Val Gly Ala Thr Cys Tyr
         270                 275                 280

 gcc atg ttc atc ggc cat gcc acg gca ctc atc cag tcc ctg gac tct      914
 Ala Met Phe Ile Gly His Ala Thr Ala Leu Ile Gln Ser Leu Asp Ser
     285                 290                 295

 tcc cgg cgt cag tac cag gag aag tac aag cag gtg gag cag tac atg      962
 Ser Arg Arg Gln Tyr Gln Glu Lys Tyr Lys Gln Val Glu Gln Tyr Met
 300                 305                 310                 315

 tcc ttc cac aag ctg cca gca gac acg cgg cag cgc atc cac gag tac     1010
 Ser Phe His Lys Leu Pro Ala Asp Thr Arg Gln Arg Ile His Glu Tyr
                 320                 325                 330

 tat gag cac cgc tac cag ggc aag atg ttc gat gag gaa agc atc ctg     1058
 Tyr Glu His Arg Tyr Gln Gly Lys Met Phe Asp Glu Glu Ser Ile Leu
             335                 340                 345

 ggc gag ctg agc gag ccg ctt cgc gag gag atc att aac ttc acc tgt     1106
 Gly Glu Leu Ser Glu Pro Leu Arg Glu Glu Ile Ile Asn Phe Thr Cys
         350                 355                 360

 cgg ggc ctg gtg gcc cac atg ccg ctg ttt gcc cat gcc gac ccc agc     1154
 Arg Gly Leu Val Ala His Met Pro Leu Phe Ala His Ala Asp Pro Ser
     365                 370                 375

 ttc gtc act gca gtt ctc acc aag ctg cgc ttt gag gtc ttc cag ccg     1202
 Phe Val Thr Ala Val Leu Thr Lys Leu Arg Phe Glu Val Phe Gln Pro
 380                 385                 390                 395

 ggg gat ctc gtg gtg cgt gag ggc tcc gtg ggg agg aag atg tac ttc     1250
 Gly Asp Leu Val Val Arg Glu Gly Ser Val Gly Arg Lys Met Tyr Phe
                 400                 405                 410

 atc cag cat ggg ctg ctc agt gtg ctg gcc cgc ggc gcc cgg gac aca     1298
 Ile Gln His Gly Leu Leu Ser Val Leu Ala Arg Gly Ala Arg Asp Thr
             415                 420                 425

 cgc ctc acc gat gga tcc tac ttt ggg gag atc tgc ctg cta act agg     1346
 Arg Leu Thr Asp Gly Ser Tyr Phe Gly Glu Ile Cys Leu Leu Thr Arg
         430                 435                 440

 ggc cgg cgc aca gcc agt gtt cgg gct gac acc tac tgc cgc ctt tac     1394
 Gly Arg Arg Thr Ala Ser Val Arg Ala Asp Thr Tyr Cys Arg Leu Tyr
     445                 450                 455

 tca ctc agc gtg gac cat ttc aat gct gtg ctt gag gag ttc ccc atg     1442
 Ser Leu Ser Val Asp His Phe Asn Ala Val Leu Glu Glu Phe Pro Met
 460                 465                 470                 475

 atg cgc cgg gcc ttt gag act gtg gcc atg gat cgg ctg ctc cgc atc     1490
 Met Arg Arg Ala Phe Glu Thr Val Ala Met Asp Arg Leu Leu Arg Ile
                 480                 485                 490

 ggc aag aag aat tcc ata ctg cag cgg aag cgc tcc gag cca agt cca     1538
 Gly Lys Lys Asn Ser Ile Leu Gln Arg Lys Arg Ser Glu Pro Ser Pro
             495                 500                 505

 ggc agc agt ggt ggc atc atg gag cag cac ttg gtg caa cat gac aga     1586
 Gly Ser Ser Gly Gly Ile Met Glu Gln His Leu Val Gln His Asp Arg
         510                 515                 520

 gac atg gct cgg ggt gtt cgg ggt cgg gcc ccg agc aca gga gct cag     1634
 Asp Met Ala Arg Gly Val Arg Gly Arg Ala Pro Ser Thr Gly Ala Gln
     525                 530                 535

 ctt agt gga aag cca gta ctg tgg gag cca ctg gta cat gcg ccc ctt     1682
 Leu Ser Gly Lys Pro Val Leu Trp Glu Pro Leu Val His Ala Pro Leu
 540                 545                 550                 555

 cag gca gct gct gtg acc tcc aat gtg gcc att gcc ctg act cat cag     1730
 Gln Ala Ala Ala Val Thr Ser Asn Val Ala Ile Ala Leu Thr His Gln
                 560                 565                 570

 cgg ggc cct ctg ccc ctc tcc cct gac tct cca gcc acc ctc ctt gct     1778
 Arg Gly Pro Leu Pro Leu Ser Pro Asp Ser Pro Ala Thr Leu Leu Ala
             575                 580                 585

 cgc tct gct tgg cgc tca gca ggc tct cca gct tcc ccg ctg gtg ccc     1826
 Arg Ser Ala Trp Arg Ser Ala Gly Ser Pro Ala Ser Pro Leu Val Pro
         590                 595                 600

 gtc cga gct ggc cca tgg gca tcc acc tcc cgc ctg ccc gcc cca cct     1874
 Val Arg Ala Gly Pro Trp Ala Ser Thr Ser Arg Leu Pro Ala Pro Pro
     605                 610                 615

 gcc cga acc ctg cac gcc agc cta tcc cgg gca ggg cgc tcc cag gtc     1922
 Ala Arg Thr Leu His Ala Ser Leu Ser Arg Ala Gly Arg Ser Gln Val
 620                 625                 630                 635

 tcc ctg ctg ggt ccc cct cca gga gga ggt gga cgg cgg cta gga cct     1970
 Ser Leu Leu Gly Pro Pro Pro Gly Gly Gly Gly Arg Arg Leu Gly Pro
                 640                 645                 650

 cgg ggc cgc cca ctc tca gcc tcc caa ccc tct ctg cct cag cgg gca     2018
 Arg Gly Arg Pro Leu Ser Ala Ser Gln Pro Ser Leu Pro Gln Arg Ala
             655                 660                 665

 aca ggc gat ggc tct cct ggg cgt aag gga tca gga agt gag cgg ctg     2066
 Thr Gly Asp Gly Ser Pro Gly Arg Lys Gly Ser Gly Ser Glu Arg Leu
         670                 675                 680

 cct ccc tca ggg ctc ctg gcc aaa cct cca agg aca gcc cag ccc ccc     2114
 Pro Pro Ser Gly Leu Leu Ala Lys Pro Pro Arg Thr Ala Gln Pro Pro
     685                 690                 695

 agg cca cca gtg cct gag cca gcc aca ccc cgg ggt ctc cag ctt tct     2162
 Arg Pro Pro Val Pro Glu Pro Ala Thr Pro Arg Gly Leu Gln Leu Ser
 700                 705                 710                 715

 gcc aac atg taa aac ctttgagtac atccagcctt agttcttggg gtgcagtagt     2217
 Ala Asn Met 






      <210> 316
      <211> 744
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (131)..(631)

      <400> 316
 cagatgcaat tcggcacgag ggtcgacttc ggcgggagcc caggtgagaa aggcccacct     60

 gtgtcctggt tgagggtctc cagggttctt tggggcccga ggccaatggt ggcagagtct    120

 acatagaact   atg ctt cgt ggt gtt ctg ggg aaa acc ttt cga ctt gtt     169
              Met Leu Arg Gly Val Leu Gly Lys Thr Phe Arg Leu Val
                1               5                  10

 ggc tat act att caa tat ggc tgt ata gct cat tgt gct ttt gaa tac      217
 Gly Tyr Thr Ile Gln Tyr Gly Cys Ile Ala His Cys Ala Phe Glu Tyr
      15                  20                  25

 gtt ggt ggt gtt gtc atg tgt tct gga cca tca atg gag cct aca att      265
 Val Gly Gly Val Val Met Cys Ser Gly Pro Ser Met Glu Pro Thr Ile
  30                  35                  40                  45

 caa aat tca gat att gtc ttt gca gaa aat ctt agt cga cat ttt tat      313
 Gln Asn Ser Asp Ile Val Phe Ala Glu Asn Leu Ser Arg His Phe Tyr
                  50                  55                  60

 ggt atc caa aga ggt gac att gtg att gca aaa agc cca agt gat cca      361
 Gly Ile Gln Arg Gly Asp Ile Val Ile Ala Lys Ser Pro Ser Asp Pro
              65                  70                  75

 aaa tca aat att tgt aaa aga gta att ggt ttg gaa gga gac aaa atc      409
 Lys Ser Asn Ile Cys Lys Arg Val Ile Gly Leu Glu Gly Asp Lys Ile
          80                  85                  90

 ctc acc act agt cca tca gat ttc ttt aaa agc cat agt tat gtg cca      457
 Leu Thr Thr Ser Pro Ser Asp Phe Phe Lys Ser His Ser Tyr Val Pro
      95                 100                 105

 atg ggt cat gtt tgg tta gaa ggt gac aat cta cag aat tct aca gat      505
 Met Gly His Val Trp Leu Glu Gly Asp Asn Leu Gln Asn Ser Thr Asp
 110                 115                 120                 125

 tcc agg tgc tat gga cct att cca tat gga cta ata aga gga cga atc      553
 Ser Arg Cys Tyr Gly Pro Ile Pro Tyr Gly Leu Ile Arg Gly Arg Ile
                 130                 135                 140

 ttc ttt aag att tgg cct ctg agt gat ttt gga ttt tta cgt gcc agc      601
 Phe Phe Lys Ile Trp Pro Leu Ser Asp Phe Gly Phe Leu Arg Ala Ser
             145                 150                 155

 cct aat ggc cac aga ttt tct gat gat tag t aagcatttat tcttttgact      652
 Pro Asn Gly His Arg Phe Ser Asp Asp 
         160                 165

 tgattattgt ctccttttca tgtgaattta ttactcccgt tgaaaccgtg tacttaccaa    712

 taaactattt gctattcaaa aaaaaaaaaa aa                                  744




      <210> 317
      <211> 2035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (147)..(1355)

      <400> 317
 tttcgtgcac aactgagagt ggcagaagct cagctgacaa ggactgggga cggcggtgtc     60

 cttgtcttgc ctttgtcgcc cccgcccctc tcttccctgg ctggacttgc ggagtccccg    120

 ccgaagaacc cgagggtccc ctggcg atg gca gaa atg aac cct gca cag ggt     173
                              Met Ala Glu Met Asn Pro Ala Gln Gly
                                1               5

 cat gtg gtt ttt gaa gac gtg gcc ata tat ttc tcc cag gag gag tgg      221
 His Val Val Phe Glu Asp Val Ala Ile Tyr Phe Ser Gln Glu Glu Trp
  10                  15                  20                  25

 ggg cat ctc gat gag gct cag aga ttg ctg tac cgt gat gtg atg ctg      269
 Gly His Leu Asp Glu Ala Gln Arg Leu Leu Tyr Arg Asp Val Met Leu
                  30                  35                  40

 gag aat ttg gcc ctt ttg tcc tca cta ggt tgt tgc cat gga gct gag      317
 Glu Asn Leu Ala Leu Leu Ser Ser Leu Gly Cys Cys His Gly Ala Glu
              45                  50                  55

 gat gag gag gca cct tta gag cca ggt gtt tct gta gga gtg tca cag      365
 Asp Glu Glu Ala Pro Leu Glu Pro Gly Val Ser Val Gly Val Ser Gln
          60                  65                  70

 gtc atg gct cca aag ccc tgt cta tct acc cag aat acc cag ccc tgt      413
 Val Met Ala Pro Lys Pro Cys Leu Ser Thr Gln Asn Thr Gln Pro Cys
      75                  80                  85

 gag aca tgt agc tca ctt ctg aag gac att ctg cgt ctg gct gag cat      461
 Glu Thr Cys Ser Ser Leu Leu Lys Asp Ile Leu Arg Leu Ala Glu His
  90                  95                 100                 105

 gac gga aca cac ccc gag cag gga ctg tac acg tgt cca gca cat ctt      509
 Asp Gly Thr His Pro Glu Gln Gly Leu Tyr Thr Cys Pro Ala His Leu
                 110                 115                 120

 cac cag cac caa aag gag cag att aga gag aaa ctt tct aga ggg gat      557
 His Gln His Gln Lys Glu Gln Ile Arg Glu Lys Leu Ser Arg Gly Asp
             125                 130                 135

 gga gga aga ccg aca ttt gtg aag aac cac aga gtt cac atg gca ggg      605
 Gly Gly Arg Pro Thr Phe Val Lys Asn His Arg Val His Met Ala Gly
         140                 145                 150

 aag acc ttc ttg tgc agt gaa tgt ggg aaa gcc ttt agc cac aaa cat      653
 Lys Thr Phe Leu Cys Ser Glu Cys Gly Lys Ala Phe Ser His Lys His
     155                 160                 165

 aaa ctt tct gac cat cag aaa atc cac act gga gaa aga act tat aag      701
 Lys Leu Ser Asp His Gln Lys Ile His Thr Gly Glu Arg Thr Tyr Lys
 170                 175                 180                 185

 tgc agc aaa tgt ggg ata ttg ttt atg gaa agg tcc aca ctc aat aga      749
 Cys Ser Lys Cys Gly Ile Leu Phe Met Glu Arg Ser Thr Leu Asn Arg
                 190                 195                 200

 cat cag aga act cac act gga gaa agg cct tat gag tgc aat gaa tgt      797
 His Gln Arg Thr His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Glu Cys
             205                 210                 215

 ggg aaa gcc ttt ctt tgt aag tct cac ctt gtt cgt cac cag aca atc      845
 Gly Lys Ala Phe Leu Cys Lys Ser His Leu Val Arg His Gln Thr Ile
         220                 225                 230

 cac tct gga gaa agg cct tat gag tgc agt gaa tgt ggg aaa ttg ttt      893
 His Ser Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Leu Phe
     235                 240                 245

 atg tgg agt tcc aca ctc att aca cat cag agg gtt cac act gga aag      941
 Met Trp Ser Ser Thr Leu Ile Thr His Gln Arg Val His Thr Gly Lys
 250                 255                 260                 265

 agg cct tat ggt tgc agt gaa tgt ggg aag ttc ttt aag tgc aac tca      989
 Arg Pro Tyr Gly Cys Ser Glu Cys Gly Lys Phe Phe Lys Cys Asn Ser
                 270                 275                 280

 aac ctc ttt agg cat tac aga att cat aca gga aaa agg tct tat ggt     1037
 Asn Leu Phe Arg His Tyr Arg Ile His Thr Gly Lys Arg Ser Tyr Gly
             285                 290                 295

 tgc agt gaa tgt ggg aaa ttc ttt atg gaa agg tct aca ctc agt aga     1085
 Cys Ser Glu Cys Gly Lys Phe Phe Met Glu Arg Ser Thr Leu Ser Arg
         300                 305                 310

 cat cag aga gtt cac act gga gaa agg cct tat gag tgc aat gaa tgt     1133
 His Gln Arg Val His Thr Gly Glu Arg Pro Tyr Glu Cys Asn Glu Cys
     315                 320                 325

 ggg aaa ttc ttc agc ttg aaa tcc gtc ctc att caa cac caa aga gtt     1181
 Gly Lys Phe Phe Ser Leu Lys Ser Val Leu Ile Gln His Gln Arg Val
 330                 335                 340                 345

 cac act gga gaa cgg cct tat gaa tgc agt gag tgt ggg aag gcc ttc     1229
 His Thr Gly Glu Arg Pro Tyr Glu Cys Ser Glu Cys Gly Lys Ala Phe
                 350                 355                 360

 ctt aca aag tcc cac ctc att tgt cat cag aca gtt cac act gca gca     1277
 Leu Thr Lys Ser His Leu Ile Cys His Gln Thr Val His Thr Ala Ala
             365                 370                 375

 aag cag tgc agt gaa tgt ggg aaa ttc ttt agg tat aac tct aca ctt     1325
 Lys Gln Cys Ser Glu Cys Gly Lys Phe Phe Arg Tyr Asn Ser Thr Leu
         380                 385                 390

 ctc aga cat cag aaa gtc cac act gga taa g gcccttatga atgcagtgga     1376
 Leu Arg His Gln Lys Val His Thr Gly 
     395                 400

 tatgggaaag ccttcagtca ccaacatatt gtggctggac agcaggcagt acacactgga   1436

 gaaagactga atgccgtgaa cgtgggtaat tatgtaggta cagctctcca gtcgctatgt   1496

 atcagagaat tcacactgca gaaatgtgtg ttcagcaaac tcgggacatt attttggttt   1556

 gactctcatc tcattagaca ttggagagtt tacactgaag aagagtcttt tcaataaagt   1616

 agaaagtggt aaagattcaa catgcaagat tgtacttatt gggcttcaga atatccacac   1676

 tagtgaaagt cttctgagta cagcaaatgt gtgacattat tttgctacta ctccacacta   1736

 cttagacatc atgtagttca cactggaaaa aggccacgta tgtgccttga atgtagccaa   1796

 aatgatgaac aacacccaga aatctgtgat ttagcactga gaactagtat tatatggttt   1856

 ttaaaaaaca atggtgaagt acatgccaca taaaatttgc catcttaact attgtaatgt   1916

 cttgtttaat acttgaagta cattaacatt gttgagcaaa gaatatcctg aactctttat   1976

 cttgtaaaat gaaactctat aaccaccatt aaaaaaacaa ctcattccca aaaaaaaaa    2035




      <210> 318
      <211> 2119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (6)..(2072)

      <400> 318
 cgttt    atg cta ctt ttt ctg aaa cat ttg ata cta aag gat cga ggg      47
          Met Leu Leu Phe Leu Lys His Leu Ile Leu Lys Asp Arg Gly
            1               5                  10

 gtc aag gaa gat gaa ctt cag agt ata tta aat tac cta ctt acg atg       95
 Val Lys Glu Asp Glu Leu Gln Ser Ile Leu Asn Tyr Leu Leu Thr Met
  15                  20                  25                  30

 cat gag gat gaa aat att cat gat gtg cta cag tta ctg gtg gct tta      143
 His Glu Asp Glu Asn Ile His Asp Val Leu Gln Leu Leu Val Ala Leu
                  35                  40                  45

 atg tcg gaa cac cca gcc tca atg ata cca gca ttt gat caa aga aat      191
 Met Ser Glu His Pro Ala Ser Met Ile Pro Ala Phe Asp Gln Arg Asn
              50                  55                  60

 gga ata agg gtg atc tac aaa tta ttg gct tct aaa agt gaa agt att      239
 Gly Ile Arg Val Ile Tyr Lys Leu Leu Ala Ser Lys Ser Glu Ser Ile
          65                  70                  75

 tgg gtt caa gct ttg aac gtt ctg gga tac ttt ctg aag cat tta ggt      287
 Trp Val Gln Ala Leu Asn Val Leu Gly Tyr Phe Leu Lys His Leu Gly
      80                  85                  90

 cac aag aga aaa gtt gaa att atg cac acc cat agt ctt ttc act ctt      335
 His Lys Arg Lys Val Glu Ile Met His Thr His Ser Leu Phe Thr Leu
  95                 100                 105                 110

 ctt gga gaa agg ctg atg ttg cat aca aac act gtg act gtc acc aca      383
 Leu Gly Glu Arg Leu Met Leu His Thr Asn Thr Val Thr Val Thr Thr
                 115                 120                 125

 tac aac aca ctt tat gag atc ttg aca gaa caa gta tgt act cag gtc      431
 Tyr Asn Thr Leu Tyr Glu Ile Leu Thr Glu Gln Val Cys Thr Gln Val
             130                 135                 140

 gta cac aaa cca cat cca gag cca gat tct aca gtg aaa att cag aat      479
 Val His Lys Pro His Pro Glu Pro Asp Ser Thr Val Lys Ile Gln Asn
         145                 150                 155

 cca atg att ctt aaa gtg gtg gca act ttg tta aaa aac tct aca cca      527
 Pro Met Ile Leu Lys Val Val Ala Thr Leu Leu Lys Asn Ser Thr Pro
     160                 165                 170

 agt gca gag ctg atg gaa gtt cgt cgt tta ttt tta tct gat atg ata      575
 Ser Ala Glu Leu Met Glu Val Arg Arg Leu Phe Leu Ser Asp Met Ile
 175                 180                 185                 190

 aaa ctt ttc agt aac agc cgt gaa aat aga aga tgc tta ttg cag tgt      623
 Lys Leu Phe Ser Asn Ser Arg Glu Asn Arg Arg Cys Leu Leu Gln Cys
                 195                 200                 205

 tca gtg tgg cag gat tgg atg ttt tct ctt ggc tat atc aat cct aaa      671
 Ser Val Trp Gln Asp Trp Met Phe Ser Leu Gly Tyr Ile Asn Pro Lys
             210                 215                 220

 aat tct gag gaa cag aag att acc gaa atg gtc tac aat atc ttc cgg      719
 Asn Ser Glu Glu Gln Lys Ile Thr Glu Met Val Tyr Asn Ile Phe Arg
         225                 230                 235

 att ctt ttg tat cat gca ata aaa tat gaa tgg gga ggc tgg aga gtc      767
 Ile Leu Leu Tyr His Ala Ile Lys Tyr Glu Trp Gly Gly Trp Arg Val
     240                 245                 250

 tgg gtg gat acc ctc tca ata gcc cat tcc aag gtc act tat gaa gct      815
 Trp Val Asp Thr Leu Ser Ile Ala His Ser Lys Val Thr Tyr Glu Ala
 255                 260                 265                 270

 cat aag gaa tac cta gcc aaa atg tat gag gaa tat caa aga caa gag      863
 His Lys Glu Tyr Leu Ala Lys Met Tyr Glu Glu Tyr Gln Arg Gln Glu
                 275                 280                 285

 gag gaa aac att aaa aag gga aag aaa ggg aat gtg agc acc atc tct      911
 Glu Glu Asn Ile Lys Lys Gly Lys Lys Gly Asn Val Ser Thr Ile Ser
             290                 295                 300

 ggt ctt tca tca cag aca aca gga gca aaa ggt gga atg gaa att cga      959
 Gly Leu Ser Ser Gln Thr Thr Gly Ala Lys Gly Gly Met Glu Ile Arg
         305                 310                 315

 gag ata gaa gat ctt tca caa agc cag agc cca gaa agt gag acc gat     1007
 Glu Ile Glu Asp Leu Ser Gln Ser Gln Ser Pro Glu Ser Glu Thr Asp
     320                 325                 330

 tac cct gtc agc aca gat act cga gac tta ctc atg tca aca aaa gtg     1055
 Tyr Pro Val Ser Thr Asp Thr Arg Asp Leu Leu Met Ser Thr Lys Val
 335                 340                 345                 350

 tca gat gat att ctt gga aat tca gat aga cca gga agt ggt gta cat     1103
 Ser Asp Asp Ile Leu Gly Asn Ser Asp Arg Pro Gly Ser Gly Val His
                 355                 360                 365

 gtg gaa gta cat gat ctt tta gta gat ata aaa gca gag aaa gtg gaa     1151
 Val Glu Val His Asp Leu Leu Val Asp Ile Lys Ala Glu Lys Val Glu
             370                 375                 380

 gca aca gaa gta aag ctc gat gat atg gat tta tca ccg gag act tta     1199
 Ala Thr Glu Val Lys Leu Asp Asp Met Asp Leu Ser Pro Glu Thr Leu
         385                 390                 395

 gta ggt gga gag aat ggt gcc ctt gtg gag gtt gaa tct ctg ttg gat     1247
 Val Gly Gly Glu Asn Gly Ala Leu Val Glu Val Glu Ser Leu Leu Asp
     400                 405                 410

 aat gta tat agt gct gct gtt gag aaa ctc cag aac aat gta cat gga     1295
 Asn Val Tyr Ser Ala Ala Val Glu Lys Leu Gln Asn Asn Val His Gly
 415                 420                 425                 430

 agt gtt ggt atc att aaa aaa aat gaa gaa aag gat aat ggt cca ttg     1343
 Ser Val Gly Ile Ile Lys Lys Asn Glu Glu Lys Asp Asn Gly Pro Leu
                 435                 440                 445

 ata aca tta gca gat gag aaa gaa gac ctt ccc aat agt agt aca tca     1391
 Ile Thr Leu Ala Asp Glu Lys Glu Asp Leu Pro Asn Ser Ser Thr Ser
             450                 455                 460

 ttt ctc ttt gat aaa ata ccc aaa cag gag gaa aaa cta ctt cct gaa     1439
 Phe Leu Phe Asp Lys Ile Pro Lys Gln Glu Glu Lys Leu Leu Pro Glu
         465                 470                 475

 ctt tct agc aat cac att att cca aat att cag gac aca caa gta cat     1487
 Leu Ser Ser Asn His Ile Ile Pro Asn Ile Gln Asp Thr Gln Val His
     480                 485                 490

 ctt ggt gtt agt gat gat ctt gga ttg ctt gct cac atg acc ggt agc     1535
 Leu Gly Val Ser Asp Asp Leu Gly Leu Leu Ala His Met Thr Gly Ser
 495                 500                 505                 510

 gta gac tta act tgt aca tcc agt ata ata gaa gaa aaa gaa ttc aaa     1583
 Val Asp Leu Thr Cys Thr Ser Ser Ile Ile Glu Glu Lys Glu Phe Lys
                 515                 520                 525

 atc cat aca act tca gat gga atg agc agt att tct gaa aga gac tta     1631
 Ile His Thr Thr Ser Asp Gly Met Ser Ser Ile Ser Glu Arg Asp Leu
             530                 535                 540

 gcg tca tca act aag ggg ctg gag tat gct gaa atg act gct aca act     1679
 Ala Ser Ser Thr Lys Gly Leu Glu Tyr Ala Glu Met Thr Ala Thr Thr
         545                 550                 555

 ctg gaa act gag tct tct agt agc aaa att gta cca aat att gat gca     1727
 Leu Glu Thr Glu Ser Ser Ser Ser Lys Ile Val Pro Asn Ile Asp Ala
     560                 565                 570

 gga agt ata att tca gat act gaa agg tct gac gat ggc aaa gaa tca     1775
 Gly Ser Ile Ile Ser Asp Thr Glu Arg Ser Asp Asp Gly Lys Glu Ser
 575                 580                 585                 590

 gga aaa gaa atc cga aaa atc caa aca act act acg aca caa gct gtg     1823
 Gly Lys Glu Ile Arg Lys Ile Gln Thr Thr Thr Thr Thr Gln Ala Val
                 595                 600                 605

 cag ggt cgg tct atc acc caa caa gac cga gat ctc cga gtt gat tta     1871
 Gln Gly Arg Ser Ile Thr Gln Gln Asp Arg Asp Leu Arg Val Asp Leu
             610                 615                 620

 gga ttt cga gga atg cca atg act gag gaa cag cga cgc cag ttt agc     1919
 Gly Phe Arg Gly Met Pro Met Thr Glu Glu Gln Arg Arg Gln Phe Ser
         625                 630                 635

 cca ggt cca cgg act aca atg ttt cgt att cct gag ttt aaa tgg tct     1967
 Pro Gly Pro Arg Thr Thr Met Phe Arg Ile Pro Glu Phe Lys Trp Ser
     640                 645                 650

 cca atg cac cag cgg ctt ctc act gat tta cta ttt gca tta gaa act     2015
 Pro Met His Gln Arg Leu Leu Thr Asp Leu Leu Phe Ala Leu Glu Thr
 655                 660                 665                 670

 gat gta cat gtt tgg agg agc cca ttc tac aaa gtc tgt aat gga ttt     2063
 Asp Val His Val Trp Arg Ser Pro Phe Tyr Lys Val Cys Asn Gly Phe
                 675                 680                 685

 tgt caa tag caatgaa aatattattt ttgtacataa cacaattcac ctcatttccc     2119
 Cys Gln 






      <210> 319
      <211> 1873
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (114)..(1148)

      <400> 319
 tttcgttggc tggcagcagc cttggactcc gcccgtggag ccctgggcct gttgacccac     60

 cagcttagga gcacccacca agctctgggt caacgtggag gtaccaggcc acc   atg     116
                                                              Met
                                                                1

 ctc agt ctc aag ctg ccc caa ctt ctt caa gtc cac cag gtc ccc cgg      164
 Leu Ser Leu Lys Leu Pro Gln Leu Leu Gln Val His Gln Val Pro Arg
               5                  10                  15

 gtg ttc tgg gaa gat ggc atc atg tct ggc tac cgc cgc ccc acc agc      212
 Val Phe Trp Glu Asp Gly Ile Met Ser Gly Tyr Arg Arg Pro Thr Ser
          20                  25                  30

 tcg gct ttg gac tgt gtc ctc agc tcc ttc cag atg acc aac gag acg      260
 Ser Ala Leu Asp Cys Val Leu Ser Ser Phe Gln Met Thr Asn Glu Thr
      35                  40                  45

 gtc aac atc tgg act cac ttc ctg ccc acc tgg tac ttc ctg tgg cgg      308
 Val Asn Ile Trp Thr His Phe Leu Pro Thr Trp Tyr Phe Leu Trp Arg
  50                  55                  60                  65

 ctc ctg gcg ctg gcg ggc ggc ccc ggc ttc cgt gcg gag ccg tac cac      356
 Leu Leu Ala Leu Ala Gly Gly Pro Gly Phe Arg Ala Glu Pro Tyr His
                  70                  75                  80

 tgg ccg ctg ctg gtc ttc ctg ctg ccc gcc tgc ctc tac ccc ttc gcg      404
 Trp Pro Leu Leu Val Phe Leu Leu Pro Ala Cys Leu Tyr Pro Phe Ala
              85                  90                  95

 tcg tgc tgc gcg cac acc ttc agc tcc atg tcg ccc cgc atg cgc cac      452
 Ser Cys Cys Ala His Thr Phe Ser Ser Met Ser Pro Arg Met Arg His
         100                 105                 110

 atc tgc tac ttc ctc gac tac ggc gcg ctc agc ctc tac agt ctg ggc      500
 Ile Cys Tyr Phe Leu Asp Tyr Gly Ala Leu Ser Leu Tyr Ser Leu Gly
     115                 120                 125

 tgc gcc ttc ccc tat gcc gcc tac tcc atg ccg gcc tcc tgg ctg cac      548
 Cys Ala Phe Pro Tyr Ala Ala Tyr Ser Met Pro Ala Ser Trp Leu His
 130                 135                 140                 145

 ggc cac ctg cac cag ttc ttt gtg cct gcc gcc gca ctc aac tcc ttc      596
 Gly His Leu His Gln Phe Phe Val Pro Ala Ala Ala Leu Asn Ser Phe
                 150                 155                 160

 ctg tgc acc ggc ccc tcc tgc tac tcc cgt ttc ctg gag ctg gaa agc      644
 Leu Cys Thr Gly Pro Ser Cys Tyr Ser Arg Phe Leu Glu Leu Glu Ser
             165                 170                 175

 cct ggg ctc agt aag gtc ctc cgc aca gga gcc ttc gcc tat cca ttc      692
 Pro Gly Leu Ser Lys Val Leu Arg Thr Gly Ala Phe Ala Tyr Pro Phe
         180                 185                 190

 ctg ttc gac aac ctc cca ctc ttt tat cgg ctc ggg ctg tgc tgg ggc      740
 Leu Phe Asp Asn Leu Pro Leu Phe Tyr Arg Leu Gly Leu Cys Trp Gly
     195                 200                 205

 agg ggc cac ggc tgt ggg cag gag gcc ctg agc acc agc cat ggc tac      788
 Arg Gly His Gly Cys Gly Gln Glu Ala Leu Ser Thr Ser His Gly Tyr
 210                 215                 220                 225

 cat ctc ttc tgc gcg ctg ctc act ggc ttc ctc ttc gcc tcc cac ctg      836
 His Leu Phe Cys Ala Leu Leu Thr Gly Phe Leu Phe Ala Ser His Leu
                 230                 235                 240

 cct gaa agg ctg gca cca gga cgc ttt gat tac atc ggc cac agc cac      884
 Pro Glu Arg Leu Ala Pro Gly Arg Phe Asp Tyr Ile Gly His Ser His
             245                 250                 255

 cag tta ttc cac atc tgt gca gtg ctg ggc acc cac ttc cag ctg gag      932
 Gln Leu Phe His Ile Cys Ala Val Leu Gly Thr His Phe Gln Leu Glu
         260                 265                 270

 gca gtg ctg gct gat atg gga tca cgc aga gcc tgg ctg gcc aca cag      980
 Ala Val Leu Ala Asp Met Gly Ser Arg Arg Ala Trp Leu Ala Thr Gln
     275                 280                 285

 gaa cct gcc ctg ggc ctg gca ggc aca gtg gcc aca ctg gtc ttg gct     1028
 Glu Pro Ala Leu Gly Leu Ala Gly Thr Val Ala Thr Leu Val Leu Ala
 290                 295                 300                 305

 gca gct ggg aac cta ctc att att gct gct ttc aca gcc acc ctg ctt     1076
 Ala Ala Gly Asn Leu Leu Ile Ile Ala Ala Phe Thr Ala Thr Leu Leu
                 310                 315                 320

 cgg gcc ccc agt aca tgc cct ctg ctg cag ggt ggc cca ctg gag ggg     1124
 Arg Ala Pro Ser Thr Cys Pro Leu Leu Gln Gly Gly Pro Leu Glu Gly
             325                 330                 335

 ggt acc cag gcc aaa caa cag taa ggccccatcc ctgaccctgt cctggagggg    1178
 Gly Thr Gln Ala Lys Gln Gln 
         340

 gcagaggcca ggccccagtg ctgacgagga gcccagattt gggcctaatc aggtggggac   1238

 gcatctcagc ctggaaccaa caggggctga ggagagaggg cacaggagag agggcagaga   1298

 agaggagggg tgtctagggg gactggcaga gtgtgagagg gaccgtgagg gggctcttga   1358

 tgggagtgga agaagtgctg agggtctgag aggggagatg catgcgtgtc caggctgaag   1418

 atgcccctat attctgtcaa aggttggcgg ggggaggtgt tggggtcctt tcatctggct   1478

 ccgtttctgg tgcttctgga agtctctgct cagcacaggg aagaactaac acgactaacc   1538

 taggcctacc ctgaatgctt cttgctaacc aggccgagag gccacacact tgccccccca   1598

 tccccacaaa ccaggtaatg ccagtttgcc agcagctatt tgcctataga gatgagtctg   1658

 tcctggtcat aactgtgtgc tcaaggtgtc caggcttttg ggggtgggcc tatctgggtg   1718

 cattatggat ggtttggtgg attgaggtgt ggggaggagg gtcctaggct agagggggta   1778

 tccctagtta gactttggga agccaccttc aatgttttct ggaacaaggc aggtacaaat   1838

 aaaaaaataa aactttggaa agcaaaaaaa aaaaa                              1873




      <210> 320
      <211> 1552
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (316)..(630)

      <400> 320
 gggagcccgc gccccgcccg ccgcgcctct gccgggaccc acccgcagcg gagggctgag     60

 cccgccggcg gctccccgga gctcacccac ctccgcgcgc cggagcgcag gcaaaagggg    120

 aggaaaggct cctctcttta gtcaccactc tcgccctctc caagaatttg tttaacaaag    180

 cgctgaggaa agagaacgtc ttcttgaatt ctttagtagg ggcggagtct gctgctgccc    240

 tgcgctgcca cctcggctac actgccctcc gcgacgaccc ctgaccagcc ggggtcacgt    300

 ccgggagacg ggatc atg aag cgc tcg gta gcc gtc tgg ctc ttg gtc ggg     351
                  Met Lys Arg Ser Val Ala Val Trp Leu Leu Val Gly
                    1               5                  10

 ctc agc ctc ggt gtc ccc cag ttc ggc aaa ggt gat att tgt gat ccc      399
 Leu Ser Leu Gly Val Pro Gln Phe Gly Lys Gly Asp Ile Cys Asp Pro
          15                  20                  25

 aat cca tgt gaa aat gga ggt atc tgt ttg cca gga ttg gct gat ggt      447
 Asn Pro Cys Glu Asn Gly Gly Ile Cys Leu Pro Gly Leu Ala Asp Gly
      30                  35                  40

 tcc ttt tcc tgt gag tgt cca gat ggc ttc aca gac ccc aac tgt tct      495
 Ser Phe Ser Cys Glu Cys Pro Asp Gly Phe Thr Asp Pro Asn Cys Ser
  45                  50                  55                  60

 agt gtt gtg gag gtt gca tca gat gaa gaa gaa cca act tca gca ggt      543
 Ser Val Val Glu Val Ala Ser Asp Glu Glu Glu Pro Thr Ser Ala Gly
                  65                  70                  75

 ccc tgc act cct cta ctc acc gag ctc ttt ttg gac tcc aaa aat ggt      591
 Pro Cys Thr Pro Leu Leu Thr Glu Leu Phe Leu Asp Ser Lys Asn Gly
              80                  85                  90

 atc cct act atg cac gtc tta ata aga agg ggc tta taa atgcgtggac       640
 Ile Pro Thr Met His Val Leu Ile Arg Arg Gly Leu 
          95                 100

 agctgcagaa aatgacagat ggccgtggat tcagataaat ttgcaaagga aaatgagagt    700

 tactggtgtg attacccaag gagccaagag gattggaagc ccagagtata taaaatccta    760

 caaaattgcc tacagtaatg atggaaagac ttgggcaatg tacaaagtga aaggcaccaa    820

 tgaagacatg gtgtttcgtg gaaacattga taacaacact ccatatgcta actctttcac    880

 accccccata aaagctcagt atgtaagact ctatccccaa gtttgtcgaa gacattgcac    940

 tttgcgaatg gaacttcttg gctgtgaact gtcgggttgt tctgagcctc tgggtatgaa   1000

 atcaggacat atacaagact atcagatcac tgcctccagc atcttcagaa cgctcaacat   1060

 ggacatgttc acttgggaac caaggaaagc tcggctggac aagcaaggca aagtgaatgc   1120

 ctggacctct ggccacaatg accagtcaca atggttacag gtggatcttc ttgttccaac   1180

 caaagtgact ggcatcatta cacaaggagc taaagatttt ggtcatgtac agtttgttgg   1240

 ctcctacaaa ctggcttaca gcaatgatgg agaacactgg actgtatacc aggatgaaaa   1300

 gcaaagaaaa gataaggttt tccagggaaa ttttgacaat gacactcaca gaaaaaatgt   1360

 catcgaccct cccatctatg cacgacacat aagaatcctt ccttggtcct ggtacgggag   1420

 gatcacattg cggtcagagc tgctgggctg cacagaggag gaatgagggg aggctacatt   1480

 tcacaaccct cttccctatt tccctaaaag tatctccatg gaatgaactg tgcaaaatct   1540

 gtaggaaact ga                                                       1552




      <210> 321
      <211> 1867
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (300)..(1430)

      <400> 321
 aaaataatta agtcttggat ctcatctaat aaccattttt tttttatccc ttgcatactg     60

 cagcttactt ttttgttaca gggtttgcat ttaaacggaa acatcatcgt ccaggaacaa    120

 atgtggtctt ttcatattat ttgggagaac agcaggactt cagtgagttg gtagcagtac    180

 aatagctcac tcgggctact gcagtctagc tgtagacatg ttaattaata tatttctctg    240

 acacctaggt gattgaaata gcaattaaag agtaattaaa atgtttactt cttgtagga     299                                                                 
 atg tca act aag atg tgg aat ata gca att acc tat gac gga tta gag      347
 Met Ser Thr Lys Met Trp Asn Ile Ala Ile Thr Tyr Asp Gly Leu Glu
   1               5                  10                  15

 gaa gat gat gag gtc ttt gaa gta att ctg aac tcc cct gtg aat gca      395
 Glu Asp Asp Glu Val Phe Glu Val Ile Leu Asn Ser Pro Val Asn Ala
              20                  25                  30

 gtt ctt ggc aca aag aca aaa gct gca gtg aaa att ttg gac tca aaa      443
 Val Leu Gly Thr Lys Thr Lys Ala Ala Val Lys Ile Leu Asp Ser Lys
          35                  40                  45

 gga gga caa tgc cat cct tca tat tcc tcc aac caa agc aag cac agc      491
 Gly Gly Gln Cys His Pro Ser Tyr Ser Ser Asn Gln Ser Lys His Ser
      50                  55                  60

 aca tgg gag aag ggc att tgg cat ctg ctg ccc cca ggg tct tcc tca      539
 Thr Trp Glu Lys Gly Ile Trp His Leu Leu Pro Pro Gly Ser Ser Ser
  65                  70                  75                  80

 tcc acc act tct ggt tcc ttt cat ctg gaa aga aga cct ctt cca tct      587
 Ser Thr Thr Ser Gly Ser Phe His Leu Glu Arg Arg Pro Leu Pro Ser
                  85                  90                  95

 tcc atg cag cta gca gtc atc agg gga gac acc ctg cgg ggc ttt gat      635
 Ser Met Gln Leu Ala Val Ile Arg Gly Asp Thr Leu Arg Gly Phe Asp
             100                 105                 110

 tct aca gat ctt tct caa agg aag ctt agg acc cgt ggg aat ggc aaa      683
 Ser Thr Asp Leu Ser Gln Arg Lys Leu Arg Thr Arg Gly Asn Gly Lys
         115                 120                 125

 aca gtt cgt cca tcc tct gtt tat aga aat gga aca gac atc atc tat      731
 Thr Val Arg Pro Ser Ser Val Tyr Arg Asn Gly Thr Asp Ile Ile Tyr
     130                 135                 140

 aat tat cat ggg ata gtt tcc ttg aaa ctg gag gat gac agt ttc cca      779
 Asn Tyr His Gly Ile Val Ser Leu Lys Leu Glu Asp Asp Ser Phe Pro
 145                 150                 155                 160

 act cac aaa agg aag gcc aaa gta tcc atc att agt cag cca caa aag      827
 Thr His Lys Arg Lys Ala Lys Val Ser Ile Ile Ser Gln Pro Gln Lys
                 165                 170                 175

 aca atc aaa gtg gca gaa ctg cct caa gca gat aag gtg gaa tcc aca      875
 Thr Ile Lys Val Ala Glu Leu Pro Gln Ala Asp Lys Val Glu Ser Thr
             180                 185                 190

 act gac tca cac ttc ccc aga cag gac cag ttg ccc tca ttt cca aag      923
 Thr Asp Ser His Phe Pro Arg Gln Asp Gln Leu Pro Ser Phe Pro Lys
         195                 200                 205

 aac tgc act ctg gaa tta aag gga ctc ttc cat ttt gaa gaa ggc atc      971
 Asn Cys Thr Leu Glu Leu Lys Gly Leu Phe His Phe Glu Glu Gly Ile
     210                 215                 220

 cag aag ctg tat cag tgc aat ggg atc gcc tgg aaa gcc tgg agt ccc     1019
 Gln Lys Leu Tyr Gln Cys Asn Gly Ile Ala Trp Lys Ala Trp Ser Pro
 225                 230                 235                 240

 caa acc aag gat gtg gaa gac aaa tcc tgt cca gcc ggg tgg cac cag     1067
 Gln Thr Lys Asp Val Glu Asp Lys Ser Cys Pro Ala Gly Trp His Gln
                 245                 250                 255

 cac tca ggc tac tgt cac atc ttg atc aca gag cag aaa ggc acc tgg     1115
 His Ser Gly Tyr Cys His Ile Leu Ile Thr Glu Gln Lys Gly Thr Trp
             260                 265                 270

 aat gcg gct gcc caa gct tgc agg gaa caa tac ctg ggc aac ctt gta     1163
 Asn Ala Ala Ala Gln Ala Cys Arg Glu Gln Tyr Leu Gly Asn Leu Val
         275                 280                 285

 act gta ttc tcc agg cag cac atg cgg tgg ctc tgg gac att ggt ggg     1211
 Thr Val Phe Ser Arg Gln His Met Arg Trp Leu Trp Asp Ile Gly Gly
     290                 295                 300

 aga aag tcc ttt tgg ata ggt ttg aac gac caa gtg cat gct ggc cac     1259
 Arg Lys Ser Phe Trp Ile Gly Leu Asn Asp Gln Val His Ala Gly His
 305                 310                 315                 320

 tgg gag tgg atc ggt ggt gaa cct gtt gcc ttc acc aat ggg aga aga     1307
 Trp Glu Trp Ile Gly Gly Glu Pro Val Ala Phe Thr Asn Gly Arg Arg
                 325                 330                 335

 ggg ccc tct cca cgc tcc aag ctt gga aag agc tgt gtt ttg gtt caa     1355
 Gly Pro Ser Pro Arg Ser Lys Leu Gly Lys Ser Cys Val Leu Val Gln
             340                 345                 350

 aga caa ggg aaa tgg caa aca aaa gac tgt agg aga gcc aaa cct cat     1403
 Arg Gln Gly Lys Trp Gln Thr Lys Asp Cys Arg Arg Ala Lys Pro His
         355                 360                 365

 aat tat gtg tgt tcc aga aaa ctc taa atata acagacccta cagggggcca     1455
 Asn Tyr Val Cys Ser Arg Lys Leu 
     370                 375

 cctggagttt gtcacctatt tattcacagg atctgtgaat attgctccat agaaaacaaa   1515

 ttgttatgat tgagtgggta tacctttgtg attctgtcta gtgaaaatgg gacattttta   1575

 atagtgccag aaagattgat aaataaatat tttttacaag ataagataca atttttgtat   1635

 ctcaatacct tttaaaataa atgccagcag tattaaaaag tgtaaggttt gtttattcca   1695

 gaagaccctc acccttaccc cattccaaat ctcagggagc accagtctca tagtccttgg   1755

 atttttttta aaaaaaattt ttggtcccgt tacctctaat gaatttattc tgaaatatgt   1815

 atcgtaggtg ctcctaccac tttagtccga gtggaaagct aaaaaacccc tt           1867




      <210> 322
      <211> 3639
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (371)..(1903)

      <400> 322
 tttcgttgaa cgagcatgaa gatttgaaat tgctccgatt ggaaggaagc ccaggttagg     60

 tttgggcacc tccaaacgca cccgttttaa agccacctgg actgaggcgt cgagctttca    120

 gctccaccaa acgctcacct ggcctggcag cgagcggcgg aagagcccgg gagcccctca    180

 cagagcgcac cgagccgggc ggagagctga gccgcaggca cccgcgtctc caggatgata    240

 ggcgacattg caacaaatct ctacacccag cagctcaggg ggctccaagc agagcagcaa    300

 gttcgaggat ccgggcgtgg agccgagtga ggccgcagcc cagcgggcct cgggcgaaaa    360

 atcttggaaa   atg tat acc agt cat gaa gat att ggg tat gat ttt gaa     409
              Met Tyr Thr Ser His Glu Asp Ile Gly Tyr Asp Phe Glu
                1               5                  10

 gat ggc ccc aaa gac aaa aag aca ctg aag ccc cac cca aac att gat      457
 Asp Gly Pro Lys Asp Lys Lys Thr Leu Lys Pro His Pro Asn Ile Asp
      15                  20                  25

 ggc gga tgg gct tgg atg atg gtg ctc tcc tct ttc ttt gtg cac atc      505
 Gly Gly Trp Ala Trp Met Met Val Leu Ser Ser Phe Phe Val His Ile
  30                  35                  40                  45

 ctc atc atg ggc tcc cag atg gcc ctg ggt gtc ctc aac gtg gaa tgg      553
 Leu Ile Met Gly Ser Gln Met Ala Leu Gly Val Leu Asn Val Glu Trp
                  50                  55                  60

 ctg gaa gaa ttc cac cag agc cgc ggc ctg acc gcc tgg gtc agc tcc      601
 Leu Glu Glu Phe His Gln Ser Arg Gly Leu Thr Ala Trp Val Ser Ser
              65                  70                  75

 ctc agc atg ggc atc acc ttg ata gtg ggc cct ttc atc ggc ttg ttc      649
 Leu Ser Met Gly Ile Thr Leu Ile Val Gly Pro Phe Ile Gly Leu Phe
          80                  85                  90

 att aac acc tgt ggg tgc cgc cag act gcg atc att gga ggg ctc gtc      697
 Ile Asn Thr Cys Gly Cys Arg Gln Thr Ala Ile Ile Gly Gly Leu Val
      95                 100                 105

 aac tcc ctg ggc tgg gtg ttg agt gcc tat gct gca aac gtg cat tat      745
 Asn Ser Leu Gly Trp Val Leu Ser Ala Tyr Ala Ala Asn Val His Tyr
 110                 115                 120                 125

 ctc ttc att act ttt gga gtc gca gct ggc ctg ggc agc ggg atg gcc      793
 Leu Phe Ile Thr Phe Gly Val Ala Ala Gly Leu Gly Ser Gly Met Ala
                 130                 135                 140

 tac ctg cca gcg gtg gtc atg gtg ggc agg tat ttc cag aag aga cgc      841
 Tyr Leu Pro Ala Val Val Met Val Gly Arg Tyr Phe Gln Lys Arg Arg
             145                 150                 155

 gcc ctc gcc cag ggc ctc agc acc acg ggg acc gga ttc ggt acg ttc      889
 Ala Leu Ala Gln Gly Leu Ser Thr Thr Gly Thr Gly Phe Gly Thr Phe
         160                 165                 170

 cta atg act gtg ctg ctg aag tac ctg tgc gca cag tac ggc tgg agg      937
 Leu Met Thr Val Leu Leu Lys Tyr Leu Cys Ala Gln Tyr Gly Trp Arg
     175                 180                 185

 aat gcc atg ttg atc caa ggt gcc gtt tcc cta aac ctg cgt gtt tgt      985
 Asn Ala Met Leu Ile Gln Gly Ala Val Ser Leu Asn Leu Arg Val Cys
 190                 195                 200                 205

 ggg gcg ctc atg agg ccc ctc tct cct ggt aaa aac cca aac gac cca     1033
 Gly Ala Leu Met Arg Pro Leu Ser Pro Gly Lys Asn Pro Asn Asp Pro
                 210                 215                 220

 gga gag aaa gat gtg cgt ggc ctg cca gcg cac tcc aca gaa tct gtg     1081
 Gly Glu Lys Asp Val Arg Gly Leu Pro Ala His Ser Thr Glu Ser Val
             225                 230                 235

 aag tca act gga cag cag gga aga aca gaa gag aag gat ggt ggg ctc     1129
 Lys Ser Thr Gly Gln Gln Gly Arg Thr Glu Glu Lys Asp Gly Gly Leu
         240                 245                 250

 ggg aac gag gag acc ctc tgc gac ctg caa gcc cag gag tgc ccc gat     1177
 Gly Asn Glu Glu Thr Leu Cys Asp Leu Gln Ala Gln Glu Cys Pro Asp
     255                 260                 265

 cag gcc ggg cac agg aag aac atg tgt gcc ctc cgg att ctg aag act     1225
 Gln Ala Gly His Arg Lys Asn Met Cys Ala Leu Arg Ile Leu Lys Thr
 270                 275                 280                 285

 gtc agc tgg ctc acc atg aga gtc agg aag ggc ttc gag gac tgg tat     1273
 Val Ser Trp Leu Thr Met Arg Val Arg Lys Gly Phe Glu Asp Trp Tyr
                 290                 295                 300

 tcg ggc tac ttt ggg aca gcc tct cta ttt aca aat cga atg ttt gta     1321
 Ser Gly Tyr Phe Gly Thr Ala Ser Leu Phe Thr Asn Arg Met Phe Val
             305                 310                 315

 gcc ttt att ttc tgg gct ttg ttt gca tac agc agc ttt gtc atc ccc     1369
 Ala Phe Ile Phe Trp Ala Leu Phe Ala Tyr Ser Ser Phe Val Ile Pro
         320                 325                 330

 ttc att cac ctc cca gaa atc gtc aat ttg tat aac tta tcg gag caa     1417
 Phe Ile His Leu Pro Glu Ile Val Asn Leu Tyr Asn Leu Ser Glu Gln
     335                 340                 345

 aac gac gtt ttc cct ctg acg tca att ata gca ata gtt cac atc ttt     1465
 Asn Asp Val Phe Pro Leu Thr Ser Ile Ile Ala Ile Val His Ile Phe
 350                 355                 360                 365

 gga aaa gtg atc ctg ggc gtc ata gcc gac ttg cct tgc att agt gtt     1513
 Gly Lys Val Ile Leu Gly Val Ile Ala Asp Leu Pro Cys Ile Ser Val
                 370                 375                 380

 tgg aat gtc ttc ctg ttg gcc aac ttc acc ctt gtc ctc agt att ttt     1561
 Trp Asn Val Phe Leu Leu Ala Asn Phe Thr Leu Val Leu Ser Ile Phe
             385                 390                 395

 att ctg ccg ttg atg cac acg tac gct ggc ctg gcg gtc atc tgt gcg     1609
 Ile Leu Pro Leu Met His Thr Tyr Ala Gly Leu Ala Val Ile Cys Ala
         400                 405                 410

 ctg ata ggg ttt tcc agt ggt tat ttc tcc cta atg ccc gta gtg act     1657
 Leu Ile Gly Phe Ser Ser Gly Tyr Phe Ser Leu Met Pro Val Val Thr
     415                 420                 425

 gaa gac ttg gtt ggc att gaa cac ctg gcc aat gcc tac ggc atc atc     1705
 Glu Asp Leu Val Gly Ile Glu His Leu Ala Asn Ala Tyr Gly Ile Ile
 430                 435                 440                 445

 atc tgt gct aat ggc atc tct gca ttg ctg gga cca cct ttt gca ggg     1753
 Ile Cys Ala Asn Gly Ile Ser Ala Leu Leu Gly Pro Pro Phe Ala Gly
                 450                 455                 460

 tgg atc tat gac atc acg caa aaa tat gat ttt tcc ttc tac ata tgt     1801
 Trp Ile Tyr Asp Ile Thr Gln Lys Tyr Asp Phe Ser Phe Tyr Ile Cys
             465                 470                 475

 ggt ttg ctt tac atg ata gga ata ctc ttt tta ctt att cag ccg tgc     1849
 Gly Leu Leu Tyr Met Ile Gly Ile Leu Phe Leu Leu Ile Gln Pro Cys
         480                 485                 490

 att cga att ata gaa caa tcc aga aga aaa tac atg gat ggt gca cat     1897
 Ile Arg Ile Ile Glu Gln Ser Arg Arg Lys Tyr Met Asp Gly Ala His
     495                 500                 505

 gtt tag tatcatgtaa tgttccgtgt aggtttcatt gtaatactca tgcctacctc      1953
 Val 
 510

 gcatggttgc tgtgaggcac ctatgacagg acgtgggaaa gcattttgta cggtaactgg   2013

 cactgtcatt tgtaaatgcc attgtcacag cctcatttgt aagcagcact gcctctctgt   2073

 ttggggagat gtaatgctgg aagatcttaa ggactacata cattctagag atgacagtgt   2133

 tgttcaaaga cagcctagta agtaattggt agaaatgccc ttataaaaac cattctcttg   2193

 tcatctactg ggactagggt tttaaataca gcttttaaaa acaaaaacag ggaataaaag   2253

 cttttcaact caaccacttc tttgtaagac aaaactgaag tatctgtgtg cttccagaaa   2313

 gcttacagat aaatgggttt caagcacaag aatatgacca gatttcagaa attaattatt   2373

 acagggagct attgatctac tagcatcaaa caaaggcaag ctctaattcc acaggtaata   2433

 caatttagtg caattaaaga aacacggctt gtatttttat gagggaattc tgcagctagg   2493

 gattgtgact cctaaatcct cctctaaaag aaggcacttg ccattaatcc taattcagtg   2553

 ctatccagtt ataaatggaa tcttgagaca aaaccttaac aaagaaataa cagtaatgat   2613

 ttccttagca gaagccgtat ttgtacgcac aacattaaat caagggctac aattcaagca   2673

 cttttattcg tatcattggc ctcttagatg atataagcat gaggtggggc ctgtaatatt   2733

 tttttctgag tttcttctgc ccaaaaatat aatatagaac taattgctaa ctgacaaata   2793

 aagttaatag ttaaatcatc tccaaggaat gttgctaatc caaagtataa cactatcaat   2853

 ttgtgaggat aataaatgga atgccattag tgtagatgtc tgtgccacat ctgacactgg   2913

 agtagtgata acaaatagcc catctctaga ctctcgtgtt gttatataga ccattcattt   2973

 gcctgagcgt ggcacagttt taaaaatagt tctcttgatt gatttcatac agaagatgac   3033

 tgtgatccat gacatctaat aatgcccttt ctttatctga gatgtctatt tttctaagcc   3093

 aaacgttttt cagactgcag aatgttcttc ccagatcatt tgaaatttct ggctgcctta   3153

 cttgtttaca gatagtttaa gactatttaa atttctactc acaatttgat catcacacac   3213

 acacaaatcc ttgaatatca ttgccagtgt cttaggtcaa atttacctaa agtgaataca   3273

 gcccattctc aattatcctt cacaattaga cgcaggaatg ctactaggaa ttggaatcaa   3333

 acaatgccac cccaagcgta attttagcca gcagtttcag ttatactcaa ccatgccctt   3393

 ctgagctgtt aacaagtgat tcaatggaca agttctcttt ttgttccatc tccattattt   3453

 cctgctctaa tgtatagtgg gagtggttgt gtaatgaaag gaccaccaaa ataataaaag   3513

 gcagctaatg gaaaggagag acaaaagcat ggttaatata tatacttaat attacctcca   3573

 atgactcggg aattgcctgt aaattattat agacaataga ttgcatgtca tactccattt   3633

 ggctca                                                              3639




      <210> 323
      <211> 2270
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (263)..(2236)

      <400> 323
 agtatattgc taagaatggt ttccagtcat tgattcctgg gtgtcttgct tgattttcat     60

 aatagcacgg ttaatgttct atagtcaagt tttatattac aattacttgc aactagttgt    120

 gaagtctgaa atattcgatt caattgcaaa ctttgagtgt agtttttgaa aagatgttat    180

 ttagactgta tatttttttc ttcttttttg agttagtgcc aattataaca ttttaatcaa    240

 actggaacaa attgctatta aa atg gat cat ttc ttt att aaa aga aag agg     292
                          Met Asp His Phe Phe Ile Lys Arg Lys Arg
                            1               5                  10

 aat agt gaa gtg aaa tat aca gaa gca tgt tca agt tca tct gtt gaa      340
 Asn Ser Glu Val Lys Tyr Thr Glu Ala Cys Ser Ser Ser Ser Val Glu
                  15                  20                  25

 tcc gga att gtg aat agt gac aat att gag aaa aat act gac tcc aat      388
 Ser Gly Ile Val Asn Ser Asp Asn Ile Glu Lys Asn Thr Asp Ser Asn
              30                  35                  40

 ctg caa act tca act tca ttt gag cca cat ttc aaa aag aaa aaa gta      436
 Leu Gln Thr Ser Thr Ser Phe Glu Pro His Phe Lys Lys Lys Lys Val
          45                  50                  55

 agt gca aga cgt tat aat gaa gat tac tta aaa tat ggc ttt atc aaa      484
 Ser Ala Arg Arg Tyr Asn Glu Asp Tyr Leu Lys Tyr Gly Phe Ile Lys
      60                  65                  70

 tgt gaa aaa ccc ttt gaa aat gac aga cct cag tgt gtt att tgt aat      532
 Cys Glu Lys Pro Phe Glu Asn Asp Arg Pro Gln Cys Val Ile Cys Asn
  75                  80                  85                  90

 aat att ctt gcg aat gaa agc tta aaa cct tcg aaa tta aaa agg cac      580
 Asn Ile Leu Ala Asn Glu Ser Leu Lys Pro Ser Lys Leu Lys Arg His
                  95                 100                 105

 tta gaa act cag cat gct gaa ctt att gat aag cct ctt gaa tat ttt      628
 Leu Glu Thr Gln His Ala Glu Leu Ile Asp Lys Pro Leu Glu Tyr Phe
             110                 115                 120

 caa aga aag aaa aaa gac ata aag tta tca aca caa ttt ctt agt tgt      676
 Gln Arg Lys Lys Lys Asp Ile Lys Leu Ser Thr Gln Phe Leu Ser Cys
         125                 130                 135

 tct act gct gtt agt gag aaa gcc tta tta tca tca tat tta gtt gca      724
 Ser Thr Ala Val Ser Glu Lys Ala Leu Leu Ser Ser Tyr Leu Val Ala
     140                 145                 150

 tat cgt gtg gca aaa gag aaa ata gct aac aca gct gct gaa aaa att      772
 Tyr Arg Val Ala Lys Glu Lys Ile Ala Asn Thr Ala Ala Glu Lys Ile
 155                 160                 165                 170

 att ctt cca gca tgt ttg gat atg gtg cgt aca ata ttt gat gat aaa      820
 Ile Leu Pro Ala Cys Leu Asp Met Val Arg Thr Ile Phe Asp Asp Lys
                 175                 180                 185

 tca gct gat aaa tta aaa act ata cct aat gat aac aca gta tct ctt      868
 Ser Ala Asp Lys Leu Lys Thr Ile Pro Asn Asp Asn Thr Val Ser Leu
             190                 195                 200

 cga att tgt act att gca gaa cat tta gaa aca atg ctt att act cgt      916
 Arg Ile Cys Thr Ile Ala Glu His Leu Glu Thr Met Leu Ile Thr Arg
         205                 210                 215

 tta cag tct ggt ata gat ttt gca atc cag ctt gat gaa agc act gat      964
 Leu Gln Ser Gly Ile Asp Phe Ala Ile Gln Leu Asp Glu Ser Thr Asp
     220                 225                 230

 att gga agc tgc aca aca ctt tta gtt tat gtc aga tat gcg tgg caa     1012
 Ile Gly Ser Cys Thr Thr Leu Leu Val Tyr Val Arg Tyr Ala Trp Gln
 235                 240                 245                 250

 gat gat ttt ttg gag gat ttt ttg tgt ttt tta aat tta acc tca cac     1060
 Asp Asp Phe Leu Glu Asp Phe Leu Cys Phe Leu Asn Leu Thr Ser His
                 255                 260                 265

 cta agt gga tta gat att ttt aca gaa tta gaa agg cgc ata gtt ggc     1108
 Leu Ser Gly Leu Asp Ile Phe Thr Glu Leu Glu Arg Arg Ile Val Gly
             270                 275                 280

 caa tat aaa tta aac tgg aaa aac tgt aaa gga att aca agt gat ggc     1156
 Gln Tyr Lys Leu Asn Trp Lys Asn Cys Lys Gly Ile Thr Ser Asp Gly
         285                 290                 295

 aca gca acc atg act gga aaa cat agc aga gta att aaa aaa tta cta     1204
 Thr Ala Thr Met Thr Gly Lys His Ser Arg Val Ile Lys Lys Leu Leu
     300                 305                 310

 gaa gtt act aat aat ggt gct gtg tgg aat cat tgt ttt ata cat cgt     1252
 Glu Val Thr Asn Asn Gly Ala Val Trp Asn His Cys Phe Ile His Arg
 315                 320                 325                 330

 gaa ggt tta gca tcc aga gaa att cca cag aat ctc atg gag gta ttg     1300
 Glu Gly Leu Ala Ser Arg Glu Ile Pro Gln Asn Leu Met Glu Val Leu
                 335                 340                 345

 aaa aat gca gtg aaa gtt gtt aat ttt att aaa gga agc tca ttg aat     1348
 Lys Asn Ala Val Lys Val Val Asn Phe Ile Lys Gly Ser Ser Leu Asn
             350                 355                 360

 agc cgg ctt ctt gaa aca ttt tgt tca gag att gga act aat cat acc     1396
 Ser Arg Leu Leu Glu Thr Phe Cys Ser Glu Ile Gly Thr Asn His Thr
         365                 370                 375

 cac tta cta tat cat acc aaa att cgt tgg ttg tct caa ggg aaa ata     1444
 His Leu Leu Tyr His Thr Lys Ile Arg Trp Leu Ser Gln Gly Lys Ile
     380                 385                 390

 cta agc agg gtt tat gag ctc agg aat gag att cac ttt ttt ctc att     1492
 Leu Ser Arg Val Tyr Glu Leu Arg Asn Glu Ile His Phe Phe Leu Ile
 395                 400                 405                 410

 gaa aaa aaa tct cat ttg gca agt att ttt gaa gat gat act tgg gta     1540
 Glu Lys Lys Ser His Leu Ala Ser Ile Phe Glu Asp Asp Thr Trp Val
                 415                 420                 425

 aca aaa ttg gca tat tta act gat att ttt agc att ctt aat gaa ctg     1588
 Thr Lys Leu Ala Tyr Leu Thr Asp Ile Phe Ser Ile Leu Asn Glu Leu
             430                 435                 440

 agt tta aaa cta cag ggg aaa aac agt gat gta ttc caa cat gtt gaa     1636
 Ser Leu Lys Leu Gln Gly Lys Asn Ser Asp Val Phe Gln His Val Glu
         445                 450                 455

 cgt atc cag gga ttt cga aag aca tta ttg tta tgg caa gta aga ctt     1684
 Arg Ile Gln Gly Phe Arg Lys Thr Leu Leu Leu Trp Gln Val Arg Leu
     460                 465                 470

 aaa agt aat cgt cct agc tat tac atg ttt cca aga ttt ttg cag cat     1732
 Lys Ser Asn Arg Pro Ser Tyr Tyr Met Phe Pro Arg Phe Leu Gln His
 475                 480                 485                 490

 att gaa gag aat att att aat gaa aac att ttg aaa gaa ata aaa tta     1780
 Ile Glu Glu Asn Ile Ile Asn Glu Asn Ile Leu Lys Glu Ile Lys Leu
                 495                 500                 505

 gag ata ttg ttg cat ctc act tct ctg tct caa act ttt aac cat ttc     1828
 Glu Ile Leu Leu His Leu Thr Ser Leu Ser Gln Thr Phe Asn His Phe
             510                 515                 520

 ttt cca gaa gaa aaa ttt gaa aca tta agg gaa aac agt tgg gta aaa     1876
 Phe Pro Glu Glu Lys Phe Glu Thr Leu Arg Glu Asn Ser Trp Val Lys
         525                 530                 535

 gat cca ttt gct ttt cga aac cct gaa tca ata att gag cta aac ttg     1924
 Asp Pro Phe Ala Phe Arg Asn Pro Glu Ser Ile Ile Glu Leu Asn Leu
     540                 545                 550

 gtg cct gaa gaa gag aat gaa tta ttg cag ctt agt tct tca tat aca     1972
 Val Pro Glu Glu Glu Asn Glu Leu Leu Gln Leu Ser Ser Ser Tyr Thr
 555                 560                 565                 570

 ttg aag aat gat tat gaa acc tta agt tta tca gca ttt tgg atg aag     2020
 Leu Lys Asn Asp Tyr Glu Thr Leu Ser Leu Ser Ala Phe Trp Met Lys
                 575                 580                 585

 gta aag gaa gac ttt cca ttg tta agt aga aag agt gtc ctg cta ttg     2068
 Val Lys Glu Asp Phe Pro Leu Leu Ser Arg Lys Ser Val Leu Leu Leu
             590                 595                 600

 cta cca ttc aca aca act agt ttg tgt gaa cta ggg ttt tcc atc tta     2116
 Leu Pro Phe Thr Thr Thr Ser Leu Cys Glu Leu Gly Phe Ser Ile Leu
         605                 610                 615

 acg cag tta aaa aca aag gaa aga aat ggg ctg aat tgt gca gca gtt     2164
 Thr Gln Leu Lys Thr Lys Glu Arg Asn Gly Leu Asn Cys Ala Ala Val
     620                 625                 630

 atg cgg gta gca tta tct tcc tgt gtt cca gac tgg aat gaa ctt atg     2212
 Met Arg Val Ala Leu Ser Ser Cys Val Pro Asp Trp Asn Glu Leu Met
 635                 640                 645                 650

 aac agg caa gca cac cca tca tag taaataaaaa tcttacctag ctttaaaaaa    2266
 Asn Arg Gln Ala His Pro Ser 
                 655

 aaaa                                                                2270




      <210> 324
      <211> 3157
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (123)..(3068)

      <400> 324
 cgacccacgc gtgcgatcgg ctgcagggac gcgcgcaagg tgaacacggg ggcttttgcg     60

 cgcaggctca tccagtgagg actggaaggt gggggcttta ggcccaggca tcggagtaga    120

 cc   atg gcc tcc agc cca tgg ggc tgt gta tgt ggc ctt ctg ctg ttg     167
      Met Ala Ser Ser Pro Trp Gly Cys Val Cys Gly Leu Leu Leu Leu
        1               5                  10                  15

 ctg ctg cca ctc ctg ggg act ggc cct gcc ctg ggg agg ggc ttt ccc      215
 Leu Leu Pro Leu Leu Gly Thr Gly Pro Ala Leu Gly Arg Gly Phe Pro
                  20                  25                  30

 agg cca ctt gaa aac tcc gaa atc cct atg atc cct gga gcc cac ccc      263
 Arg Pro Leu Glu Asn Ser Glu Ile Pro Met Ile Pro Gly Ala His Pro
              35                  40                  45

 aag ggc tct gtg ggc tca gag ccc cag gcc ttt gac gtg ttc ccg gag      311
 Lys Gly Ser Val Gly Ser Glu Pro Gln Ala Phe Asp Val Phe Pro Glu
          50                  55                  60

 aac ccc aga gct gac agt cac agg aac tct gat gtc cgc cac gcc cct      359
 Asn Pro Arg Ala Asp Ser His Arg Asn Ser Asp Val Arg His Ala Pro
      65                  70                  75

 gct gaa gag atg cct gag aag cct gta gcc tct ccc ctt ggc cca gcc      407
 Ala Glu Glu Met Pro Glu Lys Pro Val Ala Ser Pro Leu Gly Pro Ala
  80                  85                  90                  95

 ctg tac ggg ccc aaa gca gca caa gga gct cag aga gaa cga ctc cca      455
 Leu Tyr Gly Pro Lys Ala Ala Gln Gly Ala Gln Arg Glu Arg Leu Pro
                 100                 105                 110

 gta act gat gac ctc cag atg gct caa gga cca agc tcc cac ggc tgg      503
 Val Thr Asp Asp Leu Gln Met Ala Gln Gly Pro Ser Ser His Gly Trp
             115                 120                 125

 aca gga cct ctg gac tca caa gag ctt ctg gag caa gaa gca gtg gct      551
 Thr Gly Pro Leu Asp Ser Gln Glu Leu Leu Glu Gln Glu Ala Val Ala
         130                 135                 140

 ccc cac cca gtg ggc cac cct cat ctc act ttc atc ccc aca act ccc      599
 Pro His Pro Val Gly His Pro His Leu Thr Phe Ile Pro Thr Thr Pro
     145                 150                 155

 aga cgt caa ctc agg gta gcc aca gtt cct ccc tcc ctg cag cat gaa      647
 Arg Arg Gln Leu Arg Val Ala Thr Val Pro Pro Ser Leu Gln His Glu
 160                 165                 170                 175

 ggc caa gag gga cag tgg cca cct aga gat gag ggt ctg aag gcc aaa      695
 Gly Gln Glu Gly Gln Trp Pro Pro Arg Asp Glu Gly Leu Lys Ala Lys
                 180                 185                 190

 act aag agc agg gtc cca ccc act tct ccc tca gac cac cag ggc cca      743
 Thr Lys Ser Arg Val Pro Pro Thr Ser Pro Ser Asp His Gln Gly Pro
             195                 200                 205

 ccc cac acc ctt gtt tcc cac tca ggt act gtc aag agg cca gtg ctg      791
 Pro His Thr Leu Val Ser His Ser Gly Thr Val Lys Arg Pro Val Leu
         210                 215                 220

 gaa gga cag ggt ggg ttt gag gaa cac ttg cag gag gca gct caa ggt      839
 Glu Gly Gln Gly Gly Phe Glu Glu His Leu Gln Glu Ala Ala Gln Gly
     225                 230                 235

 ccc cac ttc acc cag cag gat cca gca gcc cct gat gtt ggc tca gta      887
 Pro His Phe Thr Gln Gln Asp Pro Ala Ala Pro Asp Val Gly Ser Val
 240                 245                 250                 255

 ccc cca gtt gag gtg gtg tac tct cag gag cca ggg gcc cag cca gac      935
 Pro Pro Val Glu Val Val Tyr Ser Gln Glu Pro Gly Ala Gln Pro Asp
                 260                 265                 270

 ttg gca ttg gcc aga agc ctt cct cct gct gag gag ctg ccg gtt gag      983
 Leu Ala Leu Ala Arg Ser Leu Pro Pro Ala Glu Glu Leu Pro Val Glu
             275                 280                 285

 acc ccc aag agg gct ggc gct gag gtg tcc tgg gaa gtc agc tcc cca     1031
 Thr Pro Lys Arg Ala Gly Ala Glu Val Ser Trp Glu Val Ser Ser Pro
         290                 295                 300

 ggt ccc ccg ccc aag cag gct gac ctt cct gac gct aag gat tca cca     1079
 Gly Pro Pro Pro Lys Gln Ala Asp Leu Pro Asp Ala Lys Asp Ser Pro
     305                 310                 315

 gga ccc cag ccc acg gat cca ccc gcc tca gag gct cct gat cgg ccg     1127
 Gly Pro Gln Pro Thr Asp Pro Pro Ala Ser Glu Ala Pro Asp Arg Pro
 320                 325                 330                 335

 tct aag cca gag aga gca gca atg aat gga gca gac ccc atc tcc ccc     1175
 Ser Lys Pro Glu Arg Ala Ala Met Asn Gly Ala Asp Pro Ile Ser Pro
                 340                 345                 350

 cag cgg gtg aga gga gct gtg gag gcc cca ggc acc ccc aag tct ctc     1223
 Gln Arg Val Arg Gly Ala Val Glu Ala Pro Gly Thr Pro Lys Ser Leu
             355                 360                 365

 atc cct ggt ccc tca gac cct ggc cca gct gta aac cga aca gag agc     1271
 Ile Pro Gly Pro Ser Asp Pro Gly Pro Ala Val Asn Arg Thr Glu Ser
         370                 375                 380

 ccc atg ggg gcc ctg cag cca gat gaa gcc gag gag tgg ccg ggg cgc     1319
 Pro Met Gly Ala Leu Gln Pro Asp Glu Ala Glu Glu Trp Pro Gly Arg
     385                 390                 395

 ccc caa agc cat ccc cca gca ccc cca gtc cag gcc ccc tcg acg tca     1367
 Pro Gln Ser His Pro Pro Ala Pro Pro Val Gln Ala Pro Ser Thr Ser
 400                 405                 410                 415

 cgc cgg ggc ctc att cga gtc acc acg cag cga gcc ctg ggc cag cct     1415
 Arg Arg Gly Leu Ile Arg Val Thr Thr Gln Arg Ala Leu Gly Gln Pro
                 420                 425                 430

 ccc cct ccg gag ccc acc gcc agc tcc atg gct tca gcc cca gcc tcc     1463
 Pro Pro Pro Glu Pro Thr Ala Ser Ser Met Ala Ser Ala Pro Ala Ser
             435                 440                 445

 agc ccc cca gcc aac gcc act gca ccc ccg cta cgc tgg ggc ccc ctt     1511
 Ser Pro Pro Ala Asn Ala Thr Ala Pro Pro Leu Arg Trp Gly Pro Leu
         450                 455                 460

 cgg cgg gtc ctg agc ttc tcc tgg gag ctg cac gtc tac ggg gtg ggg     1559
 Arg Arg Val Leu Ser Phe Ser Trp Glu Leu His Val Tyr Gly Val Gly
     465                 470                 475

 gta ctc ttt ctg ctg ccc gcg ttg ttg gcg ctg gct gcg ctg gca gcc     1607
 Val Leu Phe Leu Leu Pro Ala Leu Leu Ala Leu Ala Ala Leu Ala Ala
 480                 485                 490                 495

 gcc cca gca ggg ccc cgg ctg gca ttg gtg gcc gcg gtg ctg gtg ctc     1655
 Ala Pro Ala Gly Pro Arg Leu Ala Leu Val Ala Ala Val Leu Val Leu
                 500                 505                 510

 gtg gct tcg gcg ctg cga tcc gcc tac atg ctt acc gac cct tac ggc     1703
 Val Ala Ser Ala Leu Arg Ser Ala Tyr Met Leu Thr Asp Pro Tyr Gly
             515                 520                 525

 tcg cag gcg cgg ctg ggc gtt cgc ggg ggc ctg gtg ctc tac aac ctg     1751
 Ser Gln Ala Arg Leu Gly Val Arg Gly Gly Leu Val Leu Tyr Asn Leu
         530                 535                 540

 ccc ttc ccc ttg ctg ctt acg gcg ctg gca gcc ctg act ctg ctc ggc     1799
 Pro Phe Pro Leu Leu Leu Thr Ala Leu Ala Ala Leu Thr Leu Leu Gly
     545                 550                 555

 ctg ggc gcg ggg ctg ccg cca ccg ctg caa aac cca ctc ctg ctg gga     1847
 Leu Gly Ala Gly Leu Pro Pro Pro Leu Gln Asn Pro Leu Leu Leu Gly
 560                 565                 570                 575

 gca gtg gcg ctg gtg cat ggt gta ggg ttg ctc gcg aca gac ctg ctg     1895
 Ala Val Ala Leu Val His Gly Val Gly Leu Leu Ala Thr Asp Leu Leu
                 580                 585                 590

 tcc aca tgg tct gtg ctc aac ctc ctg acg cag ggc ttg tcg tgc gcc     1943
 Ser Thr Trp Ser Val Leu Asn Leu Leu Thr Gln Gly Leu Ser Cys Ala
             595                 600                 605

 tgg ggc gcg gcc gtg gct ctg ggc acg ctc tgc ctg tgc cgt cgc cgc     1991
 Trp Gly Ala Ala Val Ala Leu Gly Thr Leu Cys Leu Cys Arg Arg Arg
         610                 615                 620

 ctg ctg gac ggc cca cgg ggc tgg gat gcc agc ccg ggc cct cgg ctg     2039
 Leu Leu Asp Gly Pro Arg Gly Trp Asp Ala Ser Pro Gly Pro Arg Leu
     625                 630                 635

 ttg gct gtg gcg ggc gcg ctg ggg ctg ctg gct agc ggc ttg cag ctg     2087
 Leu Ala Val Ala Gly Ala Leu Gly Leu Leu Ala Ser Gly Leu Gln Leu
 640                 645                 650                 655

 gcg gct gcg ctc tgg ctg tac ccg ggc cca ggc cgc gtg ggc cgc ttc     2135
 Ala Ala Ala Leu Trp Leu Tyr Pro Gly Pro Gly Arg Val Gly Arg Phe
                 660                 665                 670

 tcg tgg gcc tgg tgg ggt gtc cac ttc tgg ctg cgc ctc ctg gag ctg     2183
 Ser Trp Ala Trp Trp Gly Val His Phe Trp Leu Arg Leu Leu Glu Leu
             675                 680                 685

 aca tgg gcg ctc gcc ctg gcg ttg gcc gcg gtg gct gcc gcg aga ccc     2231
 Thr Trp Ala Leu Ala Leu Ala Leu Ala Ala Val Ala Ala Ala Arg Pro
         690                 695                 700

 agg ccg ccc acg gag cac gct tgc tgg gct aag ctg atg cgt ctg gcg     2279
 Arg Pro Pro Thr Glu His Ala Cys Trp Ala Lys Leu Met Arg Leu Ala
     705                 710                 715

 tgc ccg gcg ccg tca gga aag agc gag gtg ccg gag cga ccc aat aac     2327
 Cys Pro Ala Pro Ser Gly Lys Ser Glu Val Pro Glu Arg Pro Asn Asn
 720                 725                 730                 735

 tgc tat gca ggg ccc agc aac gtt ggt gca ggc agc ttg gac atc agc     2375
 Cys Tyr Ala Gly Pro Ser Asn Val Gly Ala Gly Ser Leu Asp Ile Ser
                 740                 745                 750

 aag agc ctc atc cgc aac ccg gcg gag agt ggg cag ctg gcc acg ccc     2423
 Lys Ser Leu Ile Arg Asn Pro Ala Glu Ser Gly Gln Leu Ala Thr Pro
             755                 760                 765

 agt tca ggc gcc tgg ggc tcg gct gcg tcg ttg ggt cgc gga ccc cag     2471
 Ser Ser Gly Ala Trp Gly Ser Ala Ala Ser Leu Gly Arg Gly Pro Gln
         770                 775                 780

 ggt ggc ccg gga ctg tcc cgc aac ggt gtg gga ccg gcg cca tcg ctg     2519
 Gly Gly Pro Gly Leu Ser Arg Asn Gly Val Gly Pro Ala Pro Ser Leu
     785                 790                 795

 agc gag ctg gat ctg cgg ccg cca tcg ccc atc aac ctg agc cgc agc     2567
 Ser Glu Leu Asp Leu Arg Pro Pro Ser Pro Ile Asn Leu Ser Arg Ser
 800                 805                 810                 815

 atc gac gcc gcg ctc ttc cgc gag cac cta gtg cga gac agt gtg ttc     2615
 Ile Asp Ala Ala Leu Phe Arg Glu His Leu Val Arg Asp Ser Val Phe
                 820                 825                 830

 cag cgc tgc ggc ctc cgc ggc ctg gcc tcc ccg ccg cct gga ggc gct     2663
 Gln Arg Cys Gly Leu Arg Gly Leu Ala Ser Pro Pro Pro Gly Gly Ala
             835                 840                 845

 ctg cgg ccg cgc cgg ggc agc cat ccc aaa gcc gag ctc gac gac gct     2711
 Leu Arg Pro Arg Arg Gly Ser His Pro Lys Ala Glu Leu Asp Asp Ala
         850                 855                 860

 ggc tcc tcg ctc ctc cgc ggc cgc tgc agg tcg ctc agc gac gtg cgc     2759
 Gly Ser Ser Leu Leu Arg Gly Arg Cys Arg Ser Leu Ser Asp Val Arg
     865                 870                 875

 gtg cgc ggg ccg gtc cca cag cac gta gtg gaa gca ccc gac ggg gca     2807
 Val Arg Gly Pro Val Pro Gln His Val Val Glu Ala Pro Asp Gly Ala
 880                 885                 890                 895

 gcc gct gcg gct tct ggc agc tcc ctc gac agc ttc tcc agg ggt tca     2855
 Ala Ala Ala Ala Ser Gly Ser Ser Leu Asp Ser Phe Ser Arg Gly Ser
                 900                 905                 910

 ctc aag atc agt tgg aac ccc tgg cgc cac ggg ctg tca tca gtg gac     2903
 Leu Lys Ile Ser Trp Asn Pro Trp Arg His Gly Leu Ser Ser Val Asp
             915                 920                 925

 agt ctg ccc cta gat gag ttg ccc agc acg gta cag cta ctg cct gcc     2951
 Ser Leu Pro Leu Asp Glu Leu Pro Ser Thr Val Gln Leu Leu Pro Ala
         930                 935                 940

 ccg acc cca gcc cct gat tct acc gcc gct cgg cag ggg gac ggc cag     2999
 Pro Thr Pro Ala Pro Asp Ser Thr Ala Ala Arg Gln Gly Asp Gly Gln
     945                 950                 955

 gga gag gtc cag ccg cgc ggc aag cct ggg gaa tcc cgc agc gcc tcc     3047
 Gly Glu Val Gln Pro Arg Gly Lys Pro Gly Glu Ser Arg Ser Ala Ser
 960                 965                 970                 975

 agt gat acc atc gag ctt tga ag agcggtcctg acgcagggcc aggaccctgc     3100
 Ser Asp Thr Ile Glu Leu 
                 980

 ccgatgccca catggcatgg cctactggga cagttgagcc tttaaaaaat gggcatc      3157




      <210> 325
      <211> 2580
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (681)..(2303)

      <400> 325
 gagagcctga cggggcggta cgccgttgtg ggtggcgatc ggcatggagc accgcccacg     60

 gcgcaggtta gcggggggaa gtgcaggagc tagctaagat agagtagggg gtgctccagt    120

 taggcagccg tgtaggaggc gagttcgcgt accgtgcacg gcggcgccgg cgatgtggag    180

 ttcgctccaa gccacctgcc cgcttcatgt ggaagcgggg ttccgatacc ctatcccaca    240

 gccaggacaa tggggttgac atctatgagc ccctctacac tcagggggag accaaggtcc    300

 tgaagctgaa gaacctgcgg ccccaggact atgccagcta cacctgccag gtgtctgtgc    360

 gtaacgtgtg cggcatccca gacaagggga ggaccttccg gctcaccaac accacggcca    420

 tgaagaacgc tacattccag atcactcctg acgtgatcaa agagagtgag aacatccagc    480

 tgggccagga cctgaagcta tcgtgccacg tggatgcagt gccccaggag aaggtgacct    540

 accagtggtt caagaatggc aagccggcac gcatgtccaa gcggctgctg gtgacccgca    600

 atgatcctga gctgcccgca gtcaccagca gcctagagct cattgacctg cacttcagtg    660

 actatggcac ctacctgtgc    atg gct tct ttc cca ggg gca ccc gtg ccc     710
                          Met Ala Ser Phe Pro Gly Ala Pro Val Pro
                            1               5                  10

 gac ctc agc gtc gag gtc aac atc tcc tct gag aca gtg ccg ccc acc      758
 Asp Leu Ser Val Glu Val Asn Ile Ser Ser Glu Thr Val Pro Pro Thr
                  15                  20                  25

 atc agt gtg ccc aag ggt agg gcc gtg gtg acc gtg cgc gag gga tcg      806
 Ile Ser Val Pro Lys Gly Arg Ala Val Val Thr Val Arg Glu Gly Ser
              30                  35                  40

 cct gcc gag ctg caa tgc gag gtg cgg ggc aag ccg cgg ccg cca gtg      854
 Pro Ala Glu Leu Gln Cys Glu Val Arg Gly Lys Pro Arg Pro Pro Val
          45                  50                  55

 ctc tgg tcc cgc gtg gac aag gag gct gca ctg ctg ccc tcg ggg ctg      902
 Leu Trp Ser Arg Val Asp Lys Glu Ala Ala Leu Leu Pro Ser Gly Leu
      60                  65                  70

 ccc ctg gag gag act ccg gac ggg aag ctg cgg ctg gag cga gtg agc      950
 Pro Leu Glu Glu Thr Pro Asp Gly Lys Leu Arg Leu Glu Arg Val Ser
  75                  80                  85                  90

 cga gac atg agc ggg acc tac cgc tgc cag acg gcc cgc tat aat ggc      998
 Arg Asp Met Ser Gly Thr Tyr Arg Cys Gln Thr Ala Arg Tyr Asn Gly
                  95                 100                 105

 ttc aac gtg cgc ccc cgt gag gcc cag gtg cag ctg aac gtg cag ttc     1046
 Phe Asn Val Arg Pro Arg Glu Ala Gln Val Gln Leu Asn Val Gln Phe
             110                 115                 120

 ccg ccg gag gtg gag ccc agt tcc cag gac gtg cgc cag gcg ctg ggc     1094
 Pro Pro Glu Val Glu Pro Ser Ser Gln Asp Val Arg Gln Ala Leu Gly
         125                 130                 135

 cgg ccc gtg ctc ctg cgc tgc tcg ctg ctg cga ggc agc ccc cag cgc     1142
 Arg Pro Val Leu Leu Arg Cys Ser Leu Leu Arg Gly Ser Pro Gln Arg
     140                 145                 150

 atc gcc tcg gct gtg tgg cgt ttc aaa ggg cag ctg ctg ccg ccg ccg     1190
 Ile Ala Ser Ala Val Trp Arg Phe Lys Gly Gln Leu Leu Pro Pro Pro
 155                 160                 165                 170

 cct gtt gtt ccc gcc gcc gcc gag gcg ccg gat cac gcg gag ctg cgc     1238
 Pro Val Val Pro Ala Ala Ala Glu Ala Pro Asp His Ala Glu Leu Arg
                 175                 180                 185

 ctc gac gcc gta act cgc gac agc agc ggc agc tac gag tgc agc gtc     1286
 Leu Asp Ala Val Thr Arg Asp Ser Ser Gly Ser Tyr Glu Cys Ser Val
             190                 195                 200

 tcc aac gat gtg ggc tcg gct gcc tgc ctc ttc cag gtc tcc gcc aaa     1334
 Ser Asn Asp Val Gly Ser Ala Ala Cys Leu Phe Gln Val Ser Ala Lys
         205                 210                 215

 gcc tac agc ccg gag ttt tac ttc gac acc ccc aac ccc acc cgc agc     1382
 Ala Tyr Ser Pro Glu Phe Tyr Phe Asp Thr Pro Asn Pro Thr Arg Ser
     220                 225                 230

 cac aag ctg tcc aag aac tac tcc tac gtg ctg cag tgg act cag agg     1430
 His Lys Leu Ser Lys Asn Tyr Ser Tyr Val Leu Gln Trp Thr Gln Arg
 235                 240                 245                 250

 gag ccc gac gct gtc gac cct gtg ctc aac tac aga ctc agc atc cgc     1478
 Glu Pro Asp Ala Val Asp Pro Val Leu Asn Tyr Arg Leu Ser Ile Arg
                 255                 260                 265

 cag ttg aac cag cac aat gcg gtg gtc aag gcc atc ccg gtc cgg cgt     1526
 Gln Leu Asn Gln His Asn Ala Val Val Lys Ala Ile Pro Val Arg Arg
             270                 275                 280

 gtg gag aag ggg cag ctg ctg gag tac atc ctg acc gat ctc cgt gtg     1574
 Val Glu Lys Gly Gln Leu Leu Glu Tyr Ile Leu Thr Asp Leu Arg Val
         285                 290                 295

 ccc cac agc tat gag gtc cgc ctc aca ccc tat acc acc ttc ggg gct     1622
 Pro His Ser Tyr Glu Val Arg Leu Thr Pro Tyr Thr Thr Phe Gly Ala
     300                 305                 310

 ggt gac atg gcc tcc cgc atc atc cac tac aca gag ccc atc aac tct     1670
 Gly Asp Met Ala Ser Arg Ile Ile His Tyr Thr Glu Pro Ile Asn Ser
 315                 320                 325                 330

 ccg aac ctt tca gac aac acc tgc cac ttt gag gat gag aag atc tgt     1718
 Pro Asn Leu Ser Asp Asn Thr Cys His Phe Glu Asp Glu Lys Ile Cys
                 335                 340                 345

 ggc tat acc cag gac ctg aca gac aac ttt gac tgg acg cgg cag aat     1766
 Gly Tyr Thr Gln Asp Leu Thr Asp Asn Phe Asp Trp Thr Arg Gln Asn
             350                 355                 360

 gcc ctc acc cag aac ccc aaa cgc tcc ccc aac act ggt ccc ccc acc     1814
 Ala Leu Thr Gln Asn Pro Lys Arg Ser Pro Asn Thr Gly Pro Pro Thr
         365                 370                 375

 gac ata agt ggc acc cct gag ggc tac tac atg ttc atc gag aca tcg     1862
 Asp Ile Ser Gly Thr Pro Glu Gly Tyr Tyr Met Phe Ile Glu Thr Ser
     380                 385                 390

 agg cct cgg gag ctg ggg gac cgt gca agg tta gtg agt ccc ctc tac     1910
 Arg Pro Arg Glu Leu Gly Asp Arg Ala Arg Leu Val Ser Pro Leu Tyr
 395                 400                 405                 410

 aat gcc agc gcc aag ttc tac tgt gtc tcc ttc ttc tac cac atg tac     1958
 Asn Ala Ser Ala Lys Phe Tyr Cys Val Ser Phe Phe Tyr His Met Tyr
                 415                 420                 425

 ggg aaa cac atc ggc tcc ctc aac ctc ctg gtg cgg tcc cgg aac aaa     2006
 Gly Lys His Ile Gly Ser Leu Asn Leu Leu Val Arg Ser Arg Asn Lys
             430                 435                 440

 ggg gct ctg gac acg cac gcc tgg tct ctc agt ggc aat aag ggc aat     2054
 Gly Ala Leu Asp Thr His Ala Trp Ser Leu Ser Gly Asn Lys Gly Asn
         445                 450                 455

 gtg tgg cag cag gcc cat gtg ccc atc agc ccc agt ggg ccc ttc cag     2102
 Val Trp Gln Gln Ala His Val Pro Ile Ser Pro Ser Gly Pro Phe Gln
     460                 465                 470

 att att ttt gag ggg gtt cga ggc ccg ggc tac ctg ggg gat att gcc     2150
 Ile Ile Phe Glu Gly Val Arg Gly Pro Gly Tyr Leu Gly Asp Ile Ala
 475                 480                 485                 490

 ata gat gac gtc aca ctg aag aag ggg gag tgt ccc cgg aag cag acg     2198
 Ile Asp Asp Val Thr Leu Lys Lys Gly Glu Cys Pro Arg Lys Gln Thr
                 495                 500                 505

 gat ccc aat aaa gtg gtg gtg atg ccg ggc agt gga gcc ccc tgc cag     2246
 Asp Pro Asn Lys Val Val Val Met Pro Gly Ser Gly Ala Pro Cys Gln
             510                 515                 520

 tcc agc cca cag ctg tgg ggg ccc atg gcc atc ttc ctc ttg gcg ttg     2294
 Ser Ser Pro Gln Leu Trp Gly Pro Met Ala Ile Phe Leu Leu Ala Leu
         525                 530                 535

 cag aga tga tgagagc tgtgtggcca cccccccaac cttgcccccg gcacaccaaa     2350
 Gln Arg 
     540

 gtgtccacat tgtaccaaag actgaccccc gccagctggg gtgcccaggg gcagggccgg   2410

 cccgccaggg agggggcctg cattggctgc aaggatgagc agagaacaag gacagaggcc   2470

 aggcactgag gccctggaga cagctgttcc acttgcacac acgcacacac tcatgctcac   2530

 acacacagag atatattaaa gcacaagttt ctatctgaaa aaaaaaaaaa              2580




      <210> 326
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (46)..(894)

      <400> 326
 attggtgatg aaattttaga gatcaatggt gagaccacca aaaac    atg aag cat      54
                                                      Met Lys His
                                                        1

 tct cga gct ata gaa ctg att aag aat ggt ggc cgc aga gtt cgt ctg      102
 Ser Arg Ala Ile Glu Leu Ile Lys Asn Gly Gly Arg Arg Val Arg Leu
       5                  10                  15

 ttt ctg aag cgg gga gac ggc tca gta cca gaa tat gac ccc agc agc      150
 Phe Leu Lys Arg Gly Asp Gly Ser Val Pro Glu Tyr Asp Pro Ser Ser
  20                  25                  30                  35

 gac cgc cac ggc ccc gcc acc ggt cca caa ggt gtt ccg gaa gtg agg      198
 Asp Arg His Gly Pro Ala Thr Gly Pro Gln Gly Val Pro Glu Val Arg
                  40                  45                  50

 gcc ggg ccc gac cgc cgg cag cat ccg tca ttg gag tcc agt tac cca      246
 Ala Gly Pro Asp Arg Arg Gln His Pro Ser Leu Glu Ser Ser Tyr Pro
              55                  60                  65

 ccc gat ctt cac aaa tca tca cca cat ggg gaa aag cgg gca cac gca      294
 Pro Asp Leu His Lys Ser Ser Pro His Gly Glu Lys Arg Ala His Ala
          70                  75                  80

 agg gat ccg aaa ggc agc aga gag tat agc aga caa ccc aat gaa cac      342
 Arg Asp Pro Lys Gly Ser Arg Glu Tyr Ser Arg Gln Pro Asn Glu His
      85                  90                  95

 cac acc tgg aat ggg act tcg agg aaa ccc gac agc ggg gca tgc cga      390
 His Thr Trp Asn Gly Thr Ser Arg Lys Pro Asp Ser Gly Ala Cys Arg
 100                 105                 110                 115

 ccc aag gac cgg gcg ccg gag gga cgg agg gac gcg cag gcc gag cgc      438
 Pro Lys Asp Arg Ala Pro Glu Gly Arg Arg Asp Ala Gln Ala Glu Arg
                 120                 125                 130

 gcg gca gcc gcc aac ggc ccc aag agg cgg tcc cca gag aag cgg agg      486
 Ala Ala Ala Ala Asn Gly Pro Lys Arg Arg Ser Pro Glu Lys Arg Arg
             135                 140                 145

 gag ggc acc cgc agc gcc gac aac act ttg gag agg agg gag aag cac      534
 Glu Gly Thr Arg Ser Ala Asp Asn Thr Leu Glu Arg Arg Glu Lys His
         150                 155                 160

 gag aag aga cga gac gtc tct ccg gag cgg agg cga gag cgg tca ccc      582
 Glu Lys Arg Arg Asp Val Ser Pro Glu Arg Arg Arg Glu Arg Ser Pro
     165                 170                 175

 acc cgc agg aga gac ggc tcc ccc agc cgg cgg aga cgg tct ctg gag      630
 Thr Arg Arg Arg Asp Gly Ser Pro Ser Arg Arg Arg Arg Ser Leu Glu
 180                 185                 190                 195

 aga ctc ctg gag cag agg agg tcc ccc gag cgc agg aga ggg ggc tcg      678
 Arg Leu Leu Glu Gln Arg Arg Ser Pro Glu Arg Arg Arg Gly Gly Ser
                 200                 205                 210

 ccc gag cgc agg gcc aag tcc acc gac cgg agg cgc gca cgc tcc ccc      726
 Pro Glu Arg Arg Ala Lys Ser Thr Asp Arg Arg Arg Ala Arg Ser Pro
             215                 220                 225

 gag cgc agg aga gag cgg tcc ctg gac aaa agg aac aga gag gac aga      774
 Glu Arg Arg Arg Glu Arg Ser Leu Asp Lys Arg Asn Arg Glu Asp Arg
         230                 235                 240

 gcc agc cac cga gaa agg gaa gag gcg aat ctg aaa cag gat gcc ggc      822
 Ala Ser His Arg Glu Arg Glu Glu Ala Asn Leu Lys Gln Asp Ala Gly
     245                 250                 255

 aga agt tcc aga cat ccc ccg gag cag aga agg cga cct tac aaa gaa      870
 Arg Ser Ser Arg His Pro Pro Glu Gln Arg Arg Arg Pro Tyr Lys Glu
 260                 265                 270                 275

 tgt agc acc gac ctc agt atc tga gacgctgagt cacattccaa cctttaccgt     924
 Cys Ser Thr Asp Leu Ser Ile 
                 280

 gtcaaaggtt ctaagaggaa agtcacaaac ctgaaattat ttagtttctt acctaatgaa    984

 gcatctgaca cctgatgatc ctatgaataa caacaaacat tttatgcatt tgaaatctta   1044

 taagaaaaaa tatatatgaa aagtattgtg cctgatgtat catattaaag aaagtatttt   1104

 taaatgc                                                             1111




      <210> 327
      <211> 3104
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(2149)

      <400> 327
 agtctaagag accagcgaat tttagcagcc agtcccagcg ggctggcaac ttgcacccct     60

 tcctaggcat cctccctgat tcgcgacc   atg ctg tta agg ggc gtc ctc ctg     112
                                  Met Leu Leu Arg Gly Val Leu Leu
                                    1               5

 gcg ttg caa gcc ctg cag ctc gcc ggt gcc ctc gac ctg ccc gct ggg      160
 Ala Leu Gln Ala Leu Gln Leu Ala Gly Ala Leu Asp Leu Pro Ala Gly
      10                  15                  20

 tcc tgt gcc ttt gaa gag agc act tgc ggc ttt gac tcc gtg ttg gcc      208
 Ser Cys Ala Phe Glu Glu Ser Thr Cys Gly Phe Asp Ser Val Leu Ala
  25                  30                  35                  40

 tct ctg ccg tgg att tta aat gag gaa ggc cat tac att tat gtg gat      256
 Ser Leu Pro Trp Ile Leu Asn Glu Glu Gly His Tyr Ile Tyr Val Asp
                  45                  50                  55

 acc tcc ttt ggc aag cag ggg gag aaa gct gtg ctg cta agt cct gac      304
 Thr Ser Phe Gly Lys Gln Gly Glu Lys Ala Val Leu Leu Ser Pro Asp
              60                  65                  70

 tta cag gct gag gaa tgg agc tgc ctc cgt ttg gtc tac cag ata acc      352
 Leu Gln Ala Glu Glu Trp Ser Cys Leu Arg Leu Val Tyr Gln Ile Thr
          75                  80                  85

 aca tct tcg gag tct ctg tca gat ccc agc cag ctg aac ctc tac atg      400
 Thr Ser Ser Glu Ser Leu Ser Asp Pro Ser Gln Leu Asn Leu Tyr Met
      90                  95                 100

 aga ttt gaa gat gaa agc ttt gat cgc ttg ctt tgg tca gct aag gaa      448
 Arg Phe Glu Asp Glu Ser Phe Asp Arg Leu Leu Trp Ser Ala Lys Glu
 105                 110                 115                 120

 cct tca gac agc tgg ctc ata gcc agc ttg gat ttg caa aac agt tcc      496
 Pro Ser Asp Ser Trp Leu Ile Ala Ser Leu Asp Leu Gln Asn Ser Ser
                 125                 130                 135

 aag aaa ttc aag att tta ata gaa ggt gta cta gga cag gga aac aca      544
 Lys Lys Phe Lys Ile Leu Ile Glu Gly Val Leu Gly Gln Gly Asn Thr
             140                 145                 150

 gcc agc atc gca cta ttt gaa atc aag atg aca acc ggc tac tgt att      592
 Ala Ser Ile Ala Leu Phe Glu Ile Lys Met Thr Thr Gly Tyr Cys Ile
         155                 160                 165

 gaa tgt gac ttt gaa gaa aat cat ctc tgt ggc ttt gtg aac cgc tgg      640
 Glu Cys Asp Phe Glu Glu Asn His Leu Cys Gly Phe Val Asn Arg Trp
     170                 175                 180

 aat ccc aat gtg aac tgg ttt gtt gga gga gga agt att cgg aat gtc      688
 Asn Pro Asn Val Asn Trp Phe Val Gly Gly Gly Ser Ile Arg Asn Val
 185                 190                 195                 200

 cac tcc att ctc cca cag gat cac acc ttc aag agt gaa ctg ggc cac      736
 His Ser Ile Leu Pro Gln Asp His Thr Phe Lys Ser Glu Leu Gly His
                 205                 210                 215

 tac atg tac gtg gac tca gtt tat gtg aag cac ttc cag gag gtg gca      784
 Tyr Met Tyr Val Asp Ser Val Tyr Val Lys His Phe Gln Glu Val Ala
             220                 225                 230

 cag ctc atc tcc ccg ttg acc acg gcc ccc atg gct ggc tgc ctg tca      832
 Gln Leu Ile Ser Pro Leu Thr Thr Ala Pro Met Ala Gly Cys Leu Ser
         235                 240                 245

 ttt tat tac cag atc cag cag ggg aat gac aat gtc ttt tcc ctt tac      880
 Phe Tyr Tyr Gln Ile Gln Gln Gly Asn Asp Asn Val Phe Ser Leu Tyr
     250                 255                 260

 act cgg gat gtg gct ggc ctt tac gag gaa atc tgg aaa gca gac agg      928
 Thr Arg Asp Val Ala Gly Leu Tyr Glu Glu Ile Trp Lys Ala Asp Arg
 265                 270                 275                 280

 cca ggg aat gct gcc tgg aac ctt gcg gag gtc gag ttc aat gct cct      976
 Pro Gly Asn Ala Ala Trp Asn Leu Ala Glu Val Glu Phe Asn Ala Pro
                 285                 290                 295

 tac ccc atg gag gtt att ttt gaa gtt gct ttc aat ggt ccc aag gga     1024
 Tyr Pro Met Glu Val Ile Phe Glu Val Ala Phe Asn Gly Pro Lys Gly
             300                 305                 310

 ggt tat gtt gcc ctg gat gat att tca ttc tct cct gtt cac tgc cag     1072
 Gly Tyr Val Ala Leu Asp Asp Ile Ser Phe Ser Pro Val His Cys Gln
         315                 320                 325

 aat cag aca gaa ctt ctg ttc agt gcc gtg gaa gcc agc tgc aat ttt     1120
 Asn Gln Thr Glu Leu Leu Phe Ser Ala Val Glu Ala Ser Cys Asn Phe
     330                 335                 340

 gag caa gat ctc tgc aac ttt tac caa gat aaa gaa ggt cca ggt tgg     1168
 Glu Gln Asp Leu Cys Asn Phe Tyr Gln Asp Lys Glu Gly Pro Gly Trp
 345                 350                 355                 360

 acc cga gtg aaa gta aaa cca aac atg tat cgg gct gga gac cac act     1216
 Thr Arg Val Lys Val Lys Pro Asn Met Tyr Arg Ala Gly Asp His Thr
                 365                 370                 375

 aca ggc tta ggg tat tac ctg cta gcc aac aca aag ttc aca tct cag     1264
 Thr Gly Leu Gly Tyr Tyr Leu Leu Ala Asn Thr Lys Phe Thr Ser Gln
             380                 385                 390

 cct ggc tac att gga agg ctc tat ggg ccc tcc cta cca gga aac ttg     1312
 Pro Gly Tyr Ile Gly Arg Leu Tyr Gly Pro Ser Leu Pro Gly Asn Leu
         395                 400                 405

 cag tat tgt ctg cgt ttt cat tat gcc atc tat gga ttt tta aaa atg     1360
 Gln Tyr Cys Leu Arg Phe His Tyr Ala Ile Tyr Gly Phe Leu Lys Met
     410                 415                 420

 agt gac acc cta gca gtt tac atc ttt gaa gag aac cat gtg gtt caa     1408
 Ser Asp Thr Leu Ala Val Tyr Ile Phe Glu Glu Asn His Val Val Gln
 425                 430                 435                 440

 gag aag atc tgg tct gtg ttg gag tcc cca agg ggt gtt tgg atg caa     1456
 Glu Lys Ile Trp Ser Val Leu Glu Ser Pro Arg Gly Val Trp Met Gln
                 445                 450                 455

 gct gaa atc acc ttt aag aag ccc atg cct acc aag gtg gtt ttc atg     1504
 Ala Glu Ile Thr Phe Lys Lys Pro Met Pro Thr Lys Val Val Phe Met
             460                 465                 470

 agc cta tgc aaa agt ttc tgg gac tgt ggg ctt gta gcc ctg gat gac     1552
 Ser Leu Cys Lys Ser Phe Trp Asp Cys Gly Leu Val Ala Leu Asp Asp
         475                 480                 485

 att aca ata caa ttg gga agc tgc tca tct tca gag aaa ctt cca cct     1600
 Ile Thr Ile Gln Leu Gly Ser Cys Ser Ser Ser Glu Lys Leu Pro Pro
     490                 495                 500

 cca cct gga gag tgt act ttc gag caa gat gaa tgt aca ttt act cag     1648
 Pro Pro Gly Glu Cys Thr Phe Glu Gln Asp Glu Cys Thr Phe Thr Gln
 505                 510                 515                 520

 gag aaa aga aac cgg agc agc tgg cac agg agg agg gga gaa act ccc     1696
 Glu Lys Arg Asn Arg Ser Ser Trp His Arg Arg Arg Gly Glu Thr Pro
                 525                 530                 535

 act tcc tac aca gga cca aag gga gat cac act act ggg gta ggc tac     1744
 Thr Ser Tyr Thr Gly Pro Lys Gly Asp His Thr Thr Gly Val Gly Tyr
             540                 545                 550

 tac atg tac att gag gcc tcc cat atg gtg tat gga caa aaa gca cgc     1792
 Tyr Met Tyr Ile Glu Ala Ser His Met Val Tyr Gly Gln Lys Ala Arg
         555                 560                 565

 ctc ttg tcc agg cct ctg cga gga gtc tct gga aaa cac tgc ttg acc     1840
 Leu Leu Ser Arg Pro Leu Arg Gly Val Ser Gly Lys His Cys Leu Thr
     570                 575                 580

 ttt ttc tac cac atg tat gga ggg ggc act ggc ctg ctg agt gtt tat     1888
 Phe Phe Tyr His Met Tyr Gly Gly Gly Thr Gly Leu Leu Ser Val Tyr
 585                 590                 595                 600

 ctg aaa aag gaa gaa gac agt gaa gag tcc ctc tta tgg agg aga aga     1936
 Leu Lys Lys Glu Glu Asp Ser Glu Glu Ser Leu Leu Trp Arg Arg Arg
                 605                 610                 615

 ggt gaa cag agc att tcc tgg cta cga gca ctg att gaa tac agc tgt     1984
 Gly Glu Gln Ser Ile Ser Trp Leu Arg Ala Leu Ile Glu Tyr Ser Cys
             620                 625                 630

 gag agg caa cac cag ata att ttt gaa gcc att cga gga gta tca ata     2032
 Glu Arg Gln His Gln Ile Ile Phe Glu Ala Ile Arg Gly Val Ser Ile
         635                 640                 645

 aga agt gat att gcc att gat gat gtt aaa ttt cag gca gga ccc tgt     2080
 Arg Ser Asp Ile Ala Ile Asp Asp Val Lys Phe Gln Ala Gly Pro Cys
     650                 655                 660

 gga gaa atg gaa gat aca act caa caa tca tca gga tat tct gag gac     2128
 Gly Glu Met Glu Asp Thr Thr Gln Gln Ser Ser Gly Tyr Ser Glu Asp
 665                 670                 675                 680

 tta aat gaa att gag tat taa ga aatgatctgc attggattta ctagacgaaa     2181
 Leu Asn Glu Ile Glu Tyr 
                 685

 accatacctc tcttcaatca aaatgaaaac aaagcaaatg aatactggac agtcttaaca   2241

 attttataag ttataaaatg actttagagc accctccttc attacttttg caaaaacata   2301

 ctgactcagg gctctttttt tctttttgca tatgacaact gttactagaa atacaggcta   2361

 ctggttttgc atagatcatt catcttaatt ttggtaccag ttaaaaatac aaatgtacta   2421

 tattgtagtc attttaaagt acacaaaggg cacaatcaaa atgagatgca ctcatttaaa   2481

 tctgcattca gtgaatgtat tgggagaaaa ataggtcttg caggtttcct tttgaatttt   2541

 aagtatcata aatatttttt aagtaaataa tacggggtgt cagtaatatc tgcagaatga   2601

 atgcagtctt tcatgctaat gagttagtct ggaaaaataa agtcttattt tctatgtttt   2661

 attcatagaa atggagtatt aatttttaat attttcacca tatgtgataa caaaggatct   2721

 ttcatgaatg tccaagggta agtcagtatt aattaatgct gtattacaag gcaatgctac   2781

 cttctttatt ccccctttga actacctttg aagtcactat gagcacatgg atagaaattt   2841

 aacttttttt tgtaaagcaa gcttaaaatg tttatgtata catacccagc aacttttata   2901

 aatgtgttaa acaattttac tgatttttat aataaatatt ttggtaagat tttgaataat   2961

 atgaattcag gcagatatac taaactgctt ttatttactt gtttagaaaa ttgtatatat   3021

 atgtttgtgt atcctaacag ctgctatgaa attataaaat tacctaataa aaataatttg   3081

 aaaatcttaa aaaaaaaaaa aaa                                           3104




      <210> 328
      <211> 4280
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (267)..(3410)

      <400> 328
 cgacgattcc gtgagatgaa cacatcgcgt ttgcatccca gaaagtagtc gccgcgacta     60

 tttcccccaa agagacaagc acacatgtag gaatgacaaa ggcttgcgaa ggagagagcg    120

 cagcccgcgg cccggagaga tcccctcgat aatggattac taaatgggat acacgctgta    180

 ccagttcgct ccgagccccg gccgcctgtc cgtcgatgca ccgaaaaggg tgaagtagag    240

 aaataaagtc tccccgctga actact atg agg tca gaa gcc ttg ctg cta tat     293
                              Met Arg Ser Glu Ala Leu Leu Leu Tyr
                                1               5

 ttc aca ctg cta cac ttt gct ggg gct ggt ttc cca gaa gat tct gag      341
 Phe Thr Leu Leu His Phe Ala Gly Ala Gly Phe Pro Glu Asp Ser Glu
  10                  15                  20                  25

 cca atc agt att tcg cat ggc aac tat aca aaa cag tat ccg gtg ttt      389
 Pro Ile Ser Ile Ser His Gly Asn Tyr Thr Lys Gln Tyr Pro Val Phe
                  30                  35                  40

 gtg ggc cac aag cca gga cgg aac acc aca cag agg cac agg ctg gac      437
 Val Gly His Lys Pro Gly Arg Asn Thr Thr Gln Arg His Arg Leu Asp
              45                  50                  55

 atc cag atg att atg atc atg aac gga acc ctc tac att gct gct agg      485
 Ile Gln Met Ile Met Ile Met Asn Gly Thr Leu Tyr Ile Ala Ala Arg
          60                  65                  70

 gac cat att tat act gtt gat ata gac aca tca cac acg gaa gaa att      533
 Asp His Ile Tyr Thr Val Asp Ile Asp Thr Ser His Thr Glu Glu Ile
      75                  80                  85

 tat tgt agc aaa aaa ctg aca tgg aaa tct aga cag gcc gat gta gac      581
 Tyr Cys Ser Lys Lys Leu Thr Trp Lys Ser Arg Gln Ala Asp Val Asp
  90                  95                 100                 105

 aca tgc aga atg aag gga aaa cat aag gat gag tgc cac aac ttt att      629
 Thr Cys Arg Met Lys Gly Lys His Lys Asp Glu Cys His Asn Phe Ile
                 110                 115                 120

 aaa gtt ctt cta aag aaa aac gat gat gca ttg ttt gtc tgt gga act      677
 Lys Val Leu Leu Lys Lys Asn Asp Asp Ala Leu Phe Val Cys Gly Thr
             125                 130                 135

 aat gcc ttc aac cct tcc tgc aga aac tat aag atg gat aca ttg gaa      725
 Asn Ala Phe Asn Pro Ser Cys Arg Asn Tyr Lys Met Asp Thr Leu Glu
         140                 145                 150

 cca ttc ggg gat gaa ttc agc gga atg gcc aga tgc cca tat gat gcc      773
 Pro Phe Gly Asp Glu Phe Ser Gly Met Ala Arg Cys Pro Tyr Asp Ala
     155                 160                 165

 aaa cat gcc aac gtt gca ctg ttt gca gat gga aaa cta tac tca gcc      821
 Lys His Ala Asn Val Ala Leu Phe Ala Asp Gly Lys Leu Tyr Ser Ala
 170                 175                 180                 185

 aca gtg act gac ttc ctt gcc att gac gca gtc att tac cgg agt ctt      869
 Thr Val Thr Asp Phe Leu Ala Ile Asp Ala Val Ile Tyr Arg Ser Leu
                 190                 195                 200

 gga gaa agc cct acc ctg cgg acc gtc aag cac gat tca aaa tgg ttg      917
 Gly Glu Ser Pro Thr Leu Arg Thr Val Lys His Asp Ser Lys Trp Leu
             205                 210                 215

 aaa gaa cca tac ttt gtt caa gcc gtg gat tac gga gat tat atc tac      965
 Lys Glu Pro Tyr Phe Val Gln Ala Val Asp Tyr Gly Asp Tyr Ile Tyr
         220                 225                 230

 ttc ttc ttc agg gaa ata gca gtg gag tat aac acc atg gga aag gta     1013
 Phe Phe Phe Arg Glu Ile Ala Val Glu Tyr Asn Thr Met Gly Lys Val
     235                 240                 245

 gtt ttc cca aga gtg gct cag gtt tgt aag aat gat atg gga gga tct     1061
 Val Phe Pro Arg Val Ala Gln Val Cys Lys Asn Asp Met Gly Gly Ser
 250                 255                 260                 265

 caa aga gtc ctg gag aaa cag tgg acg tcg ttc ctg aag gcg cgc ttg     1109
 Gln Arg Val Leu Glu Lys Gln Trp Thr Ser Phe Leu Lys Ala Arg Leu
                 270                 275                 280

 aac tgc tca gtt cct gga gac tct cat ttt tat ttc aac att ctc cag     1157
 Asn Cys Ser Val Pro Gly Asp Ser His Phe Tyr Phe Asn Ile Leu Gln
             285                 290                 295

 gca gtt aca gat gtg att cgt atc aac ggg cgt gat gtt gtc ctg gca     1205
 Ala Val Thr Asp Val Ile Arg Ile Asn Gly Arg Asp Val Val Leu Ala
         300                 305                 310

 acg ttt tct aca cct tat aac agc atc cct ggg tct gca gtc tgt gcc     1253
 Thr Phe Ser Thr Pro Tyr Asn Ser Ile Pro Gly Ser Ala Val Cys Ala
     315                 320                 325

 tat gac atg ctt gac att gcc agt gtt ttt act ggg aga ttc aag gaa     1301
 Tyr Asp Met Leu Asp Ile Ala Ser Val Phe Thr Gly Arg Phe Lys Glu
 330                 335                 340                 345

 cag aag tct cct gat tcc acc tgg aca cca gtt cct gat gaa cga gtt     1349
 Gln Lys Ser Pro Asp Ser Thr Trp Thr Pro Val Pro Asp Glu Arg Val
                 350                 355                 360

 cct aag ccc agg cca ggt tgc tgt gct ggc tca tcc tcc tta gaa aga     1397
 Pro Lys Pro Arg Pro Gly Cys Cys Ala Gly Ser Ser Ser Leu Glu Arg
             365                 370                 375

 tat gca acc tcc aat gag ttc cct gat gat acc ctg aac ttc atc aag     1445
 Tyr Ala Thr Ser Asn Glu Phe Pro Asp Asp Thr Leu Asn Phe Ile Lys
         380                 385                 390

 acg cac ccg ctc atg gat gag gca gtg ccc tcc atc ttc aac agg cca     1493
 Thr His Pro Leu Met Asp Glu Ala Val Pro Ser Ile Phe Asn Arg Pro
     395                 400                 405

 tgg ttc ctg aga aca atg gtc aga tac cgc ctt acc aaa att gca gtg     1541
 Trp Phe Leu Arg Thr Met Val Arg Tyr Arg Leu Thr Lys Ile Ala Val
 410                 415                 420                 425

 gac aca gct gct ggg cca tat cag aat cac act gtg gtt ttt ctg gga     1589
 Asp Thr Ala Ala Gly Pro Tyr Gln Asn His Thr Val Val Phe Leu Gly
                 430                 435                 440

 tca gag aag gga atc atc ttg aag ttt ttg gcc aga ata gga aat agt     1637
 Ser Glu Lys Gly Ile Ile Leu Lys Phe Leu Ala Arg Ile Gly Asn Ser
             445                 450                 455

 ggt ttt cta aat gac agc ctt ttc ctg gag gag atg agt gtt tac aac     1685
 Gly Phe Leu Asn Asp Ser Leu Phe Leu Glu Glu Met Ser Val Tyr Asn
         460                 465                 470

 tct gaa aaa tgc agc tat gat gga gtc gaa gac aaa agg atc atg ggc     1733
 Ser Glu Lys Cys Ser Tyr Asp Gly Val Glu Asp Lys Arg Ile Met Gly
     475                 480                 485

 atg cag ctg gac aga gca agc agc tct ctg tat gtt gcg ttc tct acc     1781
 Met Gln Leu Asp Arg Ala Ser Ser Ser Leu Tyr Val Ala Phe Ser Thr
 490                 495                 500                 505

 tgt gtg ata aag gtt ccc ctt ggc cgg tgt gaa cga cat ggg aag tgt     1829
 Cys Val Ile Lys Val Pro Leu Gly Arg Cys Glu Arg His Gly Lys Cys
                 510                 515                 520

 aaa aaa acc tgt att gcc tcc aga gac cca tat tgt gga tgg ata aag     1877
 Lys Lys Thr Cys Ile Ala Ser Arg Asp Pro Tyr Cys Gly Trp Ile Lys
             525                 530                 535

 gaa ggt ggt gcc tgc agc cat tta tca ccc aac agc aga ctg act ttt     1925
 Glu Gly Gly Ala Cys Ser His Leu Ser Pro Asn Ser Arg Leu Thr Phe
         540                 545                 550

 gag cag gac ata gag cgt ggc aat aca gat ggt ctg ggg gac tgt cac     1973
 Glu Gln Asp Ile Glu Arg Gly Asn Thr Asp Gly Leu Gly Asp Cys His
     555                 560                 565

 aat tcc ttt gtg gca ctg aat gac att tca act cct cta cca gat aat     2021
 Asn Ser Phe Val Ala Leu Asn Asp Ile Ser Thr Pro Leu Pro Asp Asn
 570                 575                 580                 585

 gaa atg tct tac aac aca gtg tat ggg cat tcc agt tcc ctc ttg ccc     2069
 Glu Met Ser Tyr Asn Thr Val Tyr Gly His Ser Ser Ser Leu Leu Pro
                 590                 595                 600

 agc aca acc aca tca gat tcg acg gct caa gag ggg tat gag tct agg     2117
 Ser Thr Thr Thr Ser Asp Ser Thr Ala Gln Glu Gly Tyr Glu Ser Arg
             605                 610                 615

 gga gga atg ctg gac tgg aag cat ctg ctt gac tca cct gac agc aca     2165
 Gly Gly Met Leu Asp Trp Lys His Leu Leu Asp Ser Pro Asp Ser Thr
         620                 625                 630

 gac cct ttg ggg gca gtg tct tcc cat aat cac caa gac aag aag gga     2213
 Asp Pro Leu Gly Ala Val Ser Ser His Asn His Gln Asp Lys Lys Gly
     635                 640                 645

 gtg att cgg gaa agt tac ctc aaa ggc cac gac cag ctg gtt ccc gtc     2261
 Val Ile Arg Glu Ser Tyr Leu Lys Gly His Asp Gln Leu Val Pro Val
 650                 655                 660                 665

 acc ctc ttg gcc att gca gtc atc ctg gct ttc gtc atg ggg gcc gtc     2309
 Thr Leu Leu Ala Ile Ala Val Ile Leu Ala Phe Val Met Gly Ala Val
                 670                 675                 680

 ttc tcg ggc atc acc gtc tac tgc gtc tgt gat cat cgg cgc aaa gac     2357
 Phe Ser Gly Ile Thr Val Tyr Cys Val Cys Asp His Arg Arg Lys Asp
             685                 690                 695

 gtg gct gtg gtg cag cgc aag gag aag gag ctc acc cac tcg cgc cgg     2405
 Val Ala Val Val Gln Arg Lys Glu Lys Glu Leu Thr His Ser Arg Arg
         700                 705                 710

 ggc tcc atg agc agc gtc acc aag ctc agc ggc ctc ttt ggg gac act     2453
 Gly Ser Met Ser Ser Val Thr Lys Leu Ser Gly Leu Phe Gly Asp Thr
     715                 720                 725

 caa tcc aaa gac cca aag ccg gag gcc atc ctc acg cca ctc atg cac     2501
 Gln Ser Lys Asp Pro Lys Pro Glu Ala Ile Leu Thr Pro Leu Met His
 730                 735                 740                 745

 aac ggc aag ctc gcc act ccc ggc aac acg gcc aag atg ctc att aaa     2549
 Asn Gly Lys Leu Ala Thr Pro Gly Asn Thr Ala Lys Met Leu Ile Lys
                 750                 755                 760

 gca gac cag cac cac ctg gac ctg acg gcc ctc ccc acc cca gag tca     2597
 Ala Asp Gln His His Leu Asp Leu Thr Ala Leu Pro Thr Pro Glu Ser
             765                 770                 775

 acc cca acg ctg cag cag aag cgg aag ccc agc cgc ggc agc cgc gag     2645
 Thr Pro Thr Leu Gln Gln Lys Arg Lys Pro Ser Arg Gly Ser Arg Glu
         780                 785                 790

 tgg gag agg aac cag aac ctc atc aat gcc tgc aca aag gac atg ccc     2693
 Trp Glu Arg Asn Gln Asn Leu Ile Asn Ala Cys Thr Lys Asp Met Pro
     795                 800                 805

 ccc atg ggc tcc cct gtg att ccc acg gac ctg ccc ctg cgg gcc tcc     2741
 Pro Met Gly Ser Pro Val Ile Pro Thr Asp Leu Pro Leu Arg Ala Ser
 810                 815                 820                 825

 ccc agc cac atc ccc agc gtg gtg gtc ctg ccc atc acg cag cag ggc     2789
 Pro Ser His Ile Pro Ser Val Val Val Leu Pro Ile Thr Gln Gln Gly
                 830                 835                 840

 tac cag cat gag tac gtg gac cag ccc aaa atg agc gag gtg gcc cag     2837
 Tyr Gln His Glu Tyr Val Asp Gln Pro Lys Met Ser Glu Val Ala Gln
             845                 850                 855

 atg gcg ctg gag gac cag gcc gcc aca ctg gag tat aag acc atc aag     2885
 Met Ala Leu Glu Asp Gln Ala Ala Thr Leu Glu Tyr Lys Thr Ile Lys
         860                 865                 870

 gaa cat ctc agc agc aag agt ccc aac cat ggg gtg aac ctt gtg gag     2933
 Glu His Leu Ser Ser Lys Ser Pro Asn His Gly Val Asn Leu Val Glu
     875                 880                 885

 aac ctg gac agc ctg ccc ccc aaa gtt cca cag cgg gag gcc tcc ctg     2981
 Asn Leu Asp Ser Leu Pro Pro Lys Val Pro Gln Arg Glu Ala Ser Leu
 890                 895                 900                 905

 ggt ccc ccg gga gcc tcc ctg tct cag acc ggt cta agc aag cgg ctg     3029
 Gly Pro Pro Gly Ala Ser Leu Ser Gln Thr Gly Leu Ser Lys Arg Leu
                 910                 915                 920

 gaa atg cac cac tcc tct tcc tac ggg gtt gac tat aag agg agc tac     3077
 Glu Met His His Ser Ser Ser Tyr Gly Val Asp Tyr Lys Arg Ser Tyr
             925                 930                 935

 ccc acg aac tcg ctc acg aga agc cac cag gcc acc act ctc aaa aga     3125
 Pro Thr Asn Ser Leu Thr Arg Ser His Gln Ala Thr Thr Leu Lys Arg
         940                 945                 950

 aac aac act aac tcc tcc aat tcc tct cac ctc tcc aga aac cag agc     3173
 Asn Asn Thr Asn Ser Ser Asn Ser Ser His Leu Ser Arg Asn Gln Ser
     955                 960                 965

 ttt ggc agg gga gac aac ccg ccg ccc gcc ccg cag agg gtg gac tcc     3221
 Phe Gly Arg Gly Asp Asn Pro Pro Pro Ala Pro Gln Arg Val Asp Ser
 970                 975                 980                 985

 atc cag gtg cac agc tcc cag cca tct ggc cag gcc gtg act gtc tcg     3269
 Ile Gln Val His Ser Ser Gln Pro Ser Gly Gln Ala Val Thr Val Ser
                 990                 995                1000

 agg cag ccc agc ctc aac gcc tac aac tca ctg aca agg tcg ggg ctg     3317
 Arg Gln Pro Ser Leu Asn Ala Tyr Asn Ser Leu Thr Arg Ser Gly Leu
            1005                1010                1015

 aag cgt acg ccc tcg cta aag ccg gac gta ccc ccc aaa cca tcc ttt     3365
 Lys Arg Thr Pro Ser Leu Lys Pro Asp Val Pro Pro Lys Pro Ser Phe
        1020                1025                1030

 gct ccc ctt tcc aca tcc atg aag ccc aat gat gcg tgt aca taa tcc     3413
 Ala Pro Leu Ser Thr Ser Met Lys Pro Asn Asp Ala Cys Thr 
    1035                1040                1045

 cagggggagg gggtcaggtg tcgaaccagc aggcaaggcg aggtgcccgc tcagctcagc   3473

 aaggttctca actgcctcga gtacccacca gaccaagaag gcctgcggca gagccgagga   3533

 cgctgggtcc tcctctctgg gacacagggg tactcacgaa aactgggccg cgtggtttgg   3593

 tgaaggtttg caacggcggg gactcacctt cattctcttc cttcactttc ccccacaccc   3653

 tacaacaggt cggacccaca aaagacttca gttatcatca caaacatgag ccaaaagcac   3713

 atacctaccc catcccccac ccccacacac acacacacat gcacacaaca catacacaca   3773

 cacgcacaga ggtgaacaga aactgaaaca ttttgtccac aacttcacgg gacgtggcca   3833

 gactgggttt gcgttccaac ctgcaaaaca caaatacatt ttttaaaatc aagaaaattt   3893

 aaaaagacaa aaaaaaaaga attcattgat aattctaact cagactttaa caatggcaga   3953

 agtttactat gcgcaaatac tgtgaaatgc ccgccagtgt tacagctttc tgttgcagca   4013

 gataaatgcc atgttgggca actatgtcat agatttctgc tcctcctctc ttttaatgaa   4073

 ataacgtgac cgttaacgca agtaactctt tatttattgt tcaccctttt tttccttaag   4133

 gaaaggactc ttccaaatat catcctatga acagctcttc agaaagccca ttgaaagtta   4193

 aactatttaa cgtgaaatcc attaactgga ataattgagt ttctttattt ttacaataaa   4253

 ttcactgagt aaataaaaaa aaaaaaa                                       4280




      <210> 329
      <211> 1874
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (222)..(1820)

      <400> 329
 gattgtggcg tgacccggca gcggcttcct ccgttcgggc atcgctgtgc ctcgggttcg     60

 cgccccgagt gagcagtcct ggcccggagc gtcggtcctg gtaatctgta ggaaaagcgc    120

 tgcggcccag ggggtaaaga gagatcagcc tctgtggact cggtgcttct cctggcaagt    180

 aaaccccaag gaggactgac cagttcttga atttctatac c    atg gcc ctt cga     233
                                                  Met Ala Leu Arg
                                                    1

 tca gtg atg ttc agt gat gta tcc ata gac ttc tct cca gaa gag tgg      281
 Ser Val Met Phe Ser Asp Val Ser Ile Asp Phe Ser Pro Glu Glu Trp
   5                  10                  15                  20

 gaa tac ctg gac ttg gaa caa aag gac ttg tac aga gat gtc atg ttg      329
 Glu Tyr Leu Asp Leu Glu Gln Lys Asp Leu Tyr Arg Asp Val Met Leu
                  25                  30                  35

 gag aac tac agc aac ttg gtc tca ctg gga tgc ttc att tct aaa cca      377
 Glu Asn Tyr Ser Asn Leu Val Ser Leu Gly Cys Phe Ile Ser Lys Pro
              40                  45                  50

 gat gtg att tcc tca ttg gag caa gga aaa gag cct tgg aaa gtt gtg      425
 Asp Val Ile Ser Ser Leu Glu Gln Gly Lys Glu Pro Trp Lys Val Val
          55                  60                  65

 agg aaa gga aga aga caa tat cca gat ttg gag acc aag tat gag acc      473
 Arg Lys Gly Arg Arg Gln Tyr Pro Asp Leu Glu Thr Lys Tyr Glu Thr
      70                  75                  80

 aag aag tta tct tta gaa aat gac att tat gaa ata aat tta tcc cag      521
 Lys Lys Leu Ser Leu Glu Asn Asp Ile Tyr Glu Ile Asn Leu Ser Gln
  85                  90                  95                 100

 tgg aag ata atg gaa aga att gaa aac cat ggc ctt aag ggt ctc att      569
 Trp Lys Ile Met Glu Arg Ile Glu Asn His Gly Leu Lys Gly Leu Ile
                 105                 110                 115

 tta aaa aat gat tgg gaa tcc aca gga aaa att gaa gga cag gag aga      617
 Leu Lys Asn Asp Trp Glu Ser Thr Gly Lys Ile Glu Gly Gln Glu Arg
             120                 125                 130

 cct caa gaa gga tac ttc agt agt gtg aaa atg cca tct gaa aag gtg      665
 Pro Gln Glu Gly Tyr Phe Ser Ser Val Lys Met Pro Ser Glu Lys Val
         135                 140                 145

 tcc tct tac cag aaa cgc aca tct gtt act cca cat cag aga ctt cat      713
 Ser Ser Tyr Gln Lys Arg Thr Ser Val Thr Pro His Gln Arg Leu His
     150                 155                 160

 ttt gtt gat aaa ccc tat gaa tgt aag gaa tgt ggg aag gcg ttc aga      761
 Phe Val Asp Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Arg
 165                 170                 175                 180

 gtg cgc caa cag ctt act ttt cat cac aga att cat act ggt gaa aaa      809
 Val Arg Gln Gln Leu Thr Phe His His Arg Ile His Thr Gly Glu Lys
                 185                 190                 195

 ccg tat gaa tgt aag gaa tgt ggg atg gcc ttc aga cag act gca cac      857
 Pro Tyr Glu Cys Lys Glu Cys Gly Met Ala Phe Arg Gln Thr Ala His
             200                 205                 210

 ctt act cga cat cag aga ctt cat tct ggt gaa aaa ctc tat gaa tgt      905
 Leu Thr Arg His Gln Arg Leu His Ser Gly Glu Lys Leu Tyr Glu Cys
         215                 220                 225

 aag gaa tgt ggg gaa gct ttc ata tgt ggt gca gat ctt aga gta cat      953
 Lys Glu Cys Gly Glu Ala Phe Ile Cys Gly Ala Asp Leu Arg Val His
     230                 235                 240

 cag aaa atg cat att ggt gag aag ccc tat gaa tgt aaa gaa tgt ggg     1001
 Gln Lys Met His Ile Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly
 245                 250                 255                 260

 aag gct ttt agg gta cga gga caa ctt act ctg cat cag agg att cat     1049
 Lys Ala Phe Arg Val Arg Gly Gln Leu Thr Leu His Gln Arg Ile His
                 265                 270                 275

 act ggt gag aaa ccc tat gtg tgt aaa gag tgt gga aaa gcc ttt aga     1097
 Thr Gly Glu Lys Pro Tyr Val Cys Lys Glu Cys Gly Lys Ala Phe Arg
             280                 285                 290

 cag tac gca cac ctg act cgg cat cag aag ctt aat agt gct gac agg     1145
 Gln Tyr Ala His Leu Thr Arg His Gln Lys Leu Asn Ser Ala Asp Arg
         295                 300                 305

 ctc tat gaa tgc aaa gaa tgt ggg aag gcc ttt ttg tgt ggc tct ggt     1193
 Leu Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Leu Cys Gly Ser Gly
     310                 315                 320

 ctt aga gta cat cac aaa ctt cat act ggt gag aaa ccc tat gaa tgt     1241
 Leu Arg Val His His Lys Leu His Thr Gly Glu Lys Pro Tyr Glu Cys
 325                 330                 335                 340

 aag gaa tgc ggg aag gcc ttt aga gtg cga caa caa cta aca ctc cat     1289
 Lys Glu Cys Gly Lys Ala Phe Arg Val Arg Gln Gln Leu Thr Leu His
                 345                 350                 355

 cag aga att cat act ggt gag aaa ccc tat gaa tgt aag gaa tgt gga     1337
 Gln Arg Ile His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly
             360                 365                 370

 aag acc ttt agc cgt ggt tat cat ctt att ctc cat cac aga att cat     1385
 Lys Thr Phe Ser Arg Gly Tyr His Leu Ile Leu His His Arg Ile His
         375                 380                 385

 act ggt gaa aaa cct tac gaa tgt aag gaa tgc tgg aaa gcc ttt agt     1433
 Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Trp Lys Ala Phe Ser
     390                 395                 400

 cgc tac tca caa ctt att tca cat cag agt att cat att ggt gtt aag     1481
 Arg Tyr Ser Gln Leu Ile Ser His Gln Ser Ile His Ile Gly Val Lys
 405                 410                 415                 420

 ccc tat gac tgt aag gaa tgc ggg aag gcc ttc aga cta ctt tca caa     1529
 Pro Tyr Asp Cys Lys Glu Cys Gly Lys Ala Phe Arg Leu Leu Ser Gln
                 425                 430                 435

 ctc aca cag cat cag agt att cat att ggt gag aaa cct tat aaa tgt     1577
 Leu Thr Gln His Gln Ser Ile His Ile Gly Glu Lys Pro Tyr Lys Cys
             440                 445                 450

 aag gaa tgt ggc aag gcc ttt aga ttg cgc caa aaa ctt act cta cat     1625
 Lys Glu Cys Gly Lys Ala Phe Arg Leu Arg Gln Lys Leu Thr Leu His
         455                 460                 465

 cag agc att cat act ggc gaa aaa ccc ttt gag tgt aag gaa tgt agg     1673
 Gln Ser Ile His Thr Gly Glu Lys Pro Phe Glu Cys Lys Glu Cys Arg
     470                 475                 480

 aag gcc ttt aga ctt aat tca tcc ctt att caa cat ctg aga att cat     1721
 Lys Ala Phe Arg Leu Asn Ser Ser Leu Ile Gln His Leu Arg Ile His
 485                 490                 495                 500

 tct ggt gag aaa ccc tat gaa tgt aag gaa tgt aag aag gcc ttt agg     1769
 Ser Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Lys Lys Ala Phe Arg
                 505                 510                 515

 caa cat tca cac ctt act cat cat ctg aaa att cat aat gta aaa atc     1817
 Gln His Ser His Leu Thr His His Leu Lys Ile His Asn Val Lys Ile
             520                 525                 530

 taa gaaa gtcttttcaa cttctgtgtt atagaacatt ctatgaatgt agtaattaat     1874
 






      <210> 330
      <211> 2107
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (16)..(1755)

      <400> 330
 aatttcgtcc ctgcg atg cag atc tgt gga tcc agc gta gca tct gta gca      51
                  Met Gln Ile Cys Gly Ser Ser Val Ala Ser Val Ala
                    1               5                  10

 gct ggg aca tca ttc cag gtt ttg ggc ccg gtg tgt tgg caa caa ctg       99
 Ala Gly Thr Ser Phe Gln Val Leu Gly Pro Val Cys Trp Gln Gln Leu
          15                  20                  25

 gat ctg aag atg gca gtc agg gtg ctt tgg ggt ggt ctc agc ctg ctc      147
 Asp Leu Lys Met Ala Val Arg Val Leu Trp Gly Gly Leu Ser Leu Leu
      30                  35                  40

 cga gtg ctg tgg tgt ctc ctt ccg cag acg ggc tat gtg cac cca gat      195
 Arg Val Leu Trp Cys Leu Leu Pro Gln Thr Gly Tyr Val His Pro Asp
  45                  50                  55                  60

 gag ttc ttc cag tcc cct gag gtg atg gca gag gac atc ctg ggc gtt      243
 Glu Phe Phe Gln Ser Pro Glu Val Met Ala Glu Asp Ile Leu Gly Val
                  65                  70                  75

 cag gcc gcg cgg ccc tgg gag ttt tac ccc agc agc tcc tgc cgc tcg      291
 Gln Ala Ala Arg Pro Trp Glu Phe Tyr Pro Ser Ser Ser Cys Arg Ser
              80                  85                  90

 gtg ctc ttc ccc ctg ctg atc tct ggt tcc acc ttc tgg ctg ctc agg      339
 Val Leu Phe Pro Leu Leu Ile Ser Gly Ser Thr Phe Trp Leu Leu Arg
          95                 100                 105

 ctc tgg gag gag ctg ggg ccg tgg cct ggc ctg gtg agc ggc tat gcg      387
 Leu Trp Glu Glu Leu Gly Pro Trp Pro Gly Leu Val Ser Gly Tyr Ala
     110                 115                 120

 ctg ctg gtg ggg cct cga ctc ctc ctc act gcc ctt tcc ttt gct ctg      435
 Leu Leu Val Gly Pro Arg Leu Leu Leu Thr Ala Leu Ser Phe Ala Leu
 125                 130                 135                 140

 gac ggg gcc gtg tac cac ctg gcc ccg ccg atg ggg gcg gat cgc tgg      483
 Asp Gly Ala Val Tyr His Leu Ala Pro Pro Met Gly Ala Asp Arg Trp
                 145                 150                 155

 aac gcc ctg gcc ctg ctg tct ggt tcc tac gtc acc ctg gtc ttc tac      531
 Asn Ala Leu Ala Leu Leu Ser Gly Ser Tyr Val Thr Leu Val Phe Tyr
             160                 165                 170

 aca agg acc ttc tcc aac acc att gag gga ctc ctc ttc acg tgg ctg      579
 Thr Arg Thr Phe Ser Asn Thr Ile Glu Gly Leu Leu Phe Thr Trp Leu
         175                 180                 185

 ctg gtg ctg gta tcc tcc cat gta acg tgg ggc cct aca cgc aag gag      627
 Leu Val Leu Val Ser Ser His Val Thr Trp Gly Pro Thr Arg Lys Glu
     190                 195                 200

 ccg gcg ccg ggt cca cgg tgg cgc agc tgg ctt ctt gga ggc att gtg      675
 Pro Ala Pro Gly Pro Arg Trp Arg Ser Trp Leu Leu Gly Gly Ile Val
 205                 210                 215                 220

 gct gct ggc ttc ttc aac cgg ccc acc ttt ctg gcc ttt gct gtg gtc      723
 Ala Ala Gly Phe Phe Asn Arg Pro Thr Phe Leu Ala Phe Ala Val Val
                 225                 230                 235

 ccc ctc tac ctc tgg ggc act cgt gga gcc aca aac cct ggt ttg aag      771
 Pro Leu Tyr Leu Trp Gly Thr Arg Gly Ala Thr Asn Pro Gly Leu Lys
             240                 245                 250

 tct ctg acc cgg gag gcc ctg gtg ctg ctc cct ggg gca gcc ctc aca      819
 Ser Leu Thr Arg Glu Ala Leu Val Leu Leu Pro Gly Ala Ala Leu Thr
         255                 260                 265

 gca gcg gtg ttt gtg gcc acg gac agc tgg tat ttc tcc agc ccc gct      867
 Ala Ala Val Phe Val Ala Thr Asp Ser Trp Tyr Phe Ser Ser Pro Ala
     270                 275                 280

 aca tcc agg aac ctt gtc ctg aca cct gtc aac ttc ctg cac tac aac      915
 Thr Ser Arg Asn Leu Val Leu Thr Pro Val Asn Phe Leu His Tyr Asn
 285                 290                 295                 300

 ctg aat ccc caa aac ctg gcg aga cat ggc acg cac gcg cgg ctc act      963
 Leu Asn Pro Gln Asn Leu Ala Arg His Gly Thr His Ala Arg Leu Thr
                 305                 310                 315

 cac ctg gca gtc aac ggc ttc ctg ctc ttc ggg gtg ctg cat gcc cag     1011
 His Leu Ala Val Asn Gly Phe Leu Leu Phe Gly Val Leu His Ala Gln
             320                 325                 330

 gcc ctg cag gct gcg tgg caa cag ctg caa gtc ggc ctc cag gcc tct     1059
 Ala Leu Gln Ala Ala Trp Gln Gln Leu Gln Val Gly Leu Gln Ala Ser
         335                 340                 345

 gca caa atg ggc ctc ctg agg gca ctg ggt gcc cgg agc ctg ctg tcc     1107
 Ala Gln Met Gly Leu Leu Arg Ala Leu Gly Ala Arg Ser Leu Leu Ser
     350                 355                 360

 agc ccc agg tcc tat ctc ctt ctc ctc tac ttc atg cct ctg gcc ctg     1155
 Ser Pro Arg Ser Tyr Leu Leu Leu Leu Tyr Phe Met Pro Leu Ala Leu
 365                 370                 375                 380

 cta tct gcc ttt agc cac cag gag gct cgg ttc ctg att ccc ctc ctg     1203
 Leu Ser Ala Phe Ser His Gln Glu Ala Arg Phe Leu Ile Pro Leu Leu
                 385                 390                 395

 gtc ccc ctg gtc ctg ctt tgt agt cca cag acg cag cct gtg cct tgg     1251
 Val Pro Leu Val Leu Leu Cys Ser Pro Gln Thr Gln Pro Val Pro Trp
             400                 405                 410

 aag ggc act gtg gtc ctc ttc aac gcc ctc ggt gcc ctc ctc ttc ggc     1299
 Lys Gly Thr Val Val Leu Phe Asn Ala Leu Gly Ala Leu Leu Phe Gly
         415                 420                 425

 tgc ctg cat cag ggg ggc ctg gtg cct ggc ctg gag tac ctg gag cag     1347
 Cys Leu His Gln Gly Gly Leu Val Pro Gly Leu Glu Tyr Leu Glu Gln
     430                 435                 440

 gtg gtc cat gcc cct gtg ctc cca agc aca ccc acc cac tac aca ctc     1395
 Val Val His Ala Pro Val Leu Pro Ser Thr Pro Thr His Tyr Thr Leu
 445                 450                 455                 460

 ctc ttc act cac acc tac atg ccc ccc cgg cac ctc cta cac ctc cca     1443
 Leu Phe Thr His Thr Tyr Met Pro Pro Arg His Leu Leu His Leu Pro
                 465                 470                 475

 ggc ctg ggg gca cca gtg gag gtg gtg gac atg ggg ggg act gag gac     1491
 Gly Leu Gly Ala Pro Val Glu Val Val Asp Met Gly Gly Thr Glu Asp
             480                 485                 490

 tgg gcc ctg tgc caa acc ctg aaa agc ttc acc aga caa cca gcc tgc     1539
 Trp Ala Leu Cys Gln Thr Leu Lys Ser Phe Thr Arg Gln Pro Ala Cys
         495                 500                 505

 caa gtg gct ggt ggg cca tgg ctc tgc cgc ctc ttt gtg gta acc cct     1587
 Gln Val Ala Gly Gly Pro Trp Leu Cys Arg Leu Phe Val Val Thr Pro
     510                 515                 520

 ggc acc acc agg cgt gcc gtg gag aag tgc agc ttc ccc ttc aag aat     1635
 Gly Thr Thr Arg Arg Ala Val Glu Lys Cys Ser Phe Pro Phe Lys Asn
 525                 530                 535                 540

 gaa aca ctt tta ttt ccc cat ctg acc ctg gag gat cca cca gcc ctg     1683
 Glu Thr Leu Leu Phe Pro His Leu Thr Leu Glu Asp Pro Pro Ala Leu
                 545                 550                 555

 tcc tcc ttg ctg agt ggg gct tgg agg gac cac ctc agt ctt cac att     1731
 Ser Ser Leu Leu Ser Gly Ala Trp Arg Asp His Leu Ser Leu His Ile
             560                 565                 570

 gtg gag ctg ggg gaa gaa acc tga caatatgaca gagcacccac tgcccaagac    1785
 Val Glu Leu Gly Glu Glu Thr 
         575

 tcagccatag aagatgccgc cccaccttct acttgggtag ctgggctggg acgctgggac   1845

 aggaccccgt cctccttcat gactcccact gctgcctctc ctgggcatgg ctgttagctg   1905

 ttctgccttc tgggtgagct ggcactcttc tccctgagac caaagatttg acctgtcggt   1965

 cttgatgtca aggtccccaa agaccaggtt aagtgacgac acctgtctgt tcctgccctg   2025

 ttgcttccag ccactgtgat gtttgaaata tgtgatagta cctggttgtg aaaaaagaca   2085

 atgaactgct aaaaaaaaaa aa                                            2107




      <210> 331
      <211> 1154
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1068)

      <400> 331
  atg ccc agg cct aca cta gcc cca gat cag ggc cat cag gac ctg aca      48
  Met Pro Arg Pro Thr Leu Ala Pro Asp Gln Gly His Gln Asp Leu Thr
    1               5                  10                  15

 aat cat tca tca ctt gag gca aaa gat ggc cct gac tcc cct gaa gat       96
 Asn His Ser Ser Leu Glu Ala Lys Asp Gly Pro Asp Ser Pro Glu Asp
              20                  25                  30

 cat agc cat tca gta agg cat ccc aga ctc ctt tac tcc ctt acc aaa      144
 His Ser His Ser Val Arg His Pro Arg Leu Leu Tyr Ser Leu Thr Lys
          35                  40                  45

 aac act aat cca tcg cag ata cga ctt aga aag agc ctt cag ggc tac      192
 Asn Thr Asn Pro Ser Gln Ile Arg Leu Arg Lys Ser Leu Gln Gly Tyr
      50                  55                  60

 cta ata atg act aaa att tac gta gtg ctt act ctg tgc cag ccc ctt      240
 Leu Ile Met Thr Lys Ile Tyr Val Val Leu Thr Leu Cys Gln Pro Leu
  65                  70                  75                  80

 tac tat gaa tgt tat aac aat aac ctc att tct atg aat gtt ata aca      288
 Tyr Tyr Glu Cys Tyr Asn Asn Asn Leu Ile Ser Met Asn Val Ile Thr
                  85                  90                  95

 ata acc tca caa cag ccc cat gat ggc att att tct att gtt tcc att      336
 Ile Thr Ser Gln Gln Pro His Asp Gly Ile Ile Ser Ile Val Ser Ile
             100                 105                 110

 ttg tat gat aac att gag ata ata gtt gga gaa act gct gtc ttt tgc      384
 Leu Tyr Asp Asn Ile Glu Ile Ile Val Gly Glu Thr Ala Val Phe Cys
         115                 120                 125

 cta caa cta gcc aca agg gat ttt gaa aac cag gaa aaa act att tta      432
 Leu Gln Leu Ala Thr Arg Asp Phe Glu Asn Gln Glu Lys Thr Ile Leu
     130                 135                 140

 act gga gac tgt tgc tat ata aac ccg ctg gtg cgc cga act gtc cga      480
 Thr Gly Asp Cys Cys Tyr Ile Asn Pro Leu Val Arg Arg Thr Val Arg
 145                 150                 155                 160

 ttt ctt gga att tat aca ttt gga ctg ttt gct aca gat atc ttt gta      528
 Phe Leu Gly Ile Tyr Thr Phe Gly Leu Phe Ala Thr Asp Ile Phe Val
                 165                 170                 175

 aat gct gga caa gta gtc aca gga aat ctg gcc cca cat ttc ctt gcc      576
 Asn Ala Gly Gln Val Val Thr Gly Asn Leu Ala Pro His Phe Leu Ala
             180                 185                 190

 ctg tgt aag ccc aat tat aca gca ctt gga tgt cag cag tat aca caa      624
 Leu Cys Lys Pro Asn Tyr Thr Ala Leu Gly Cys Gln Gln Tyr Thr Gln
         195                 200                 205

 ttc atc agt ggg gaa gag gcc tgt act ggc aac cca gat ctc atc atg      672
 Phe Ile Ser Gly Glu Glu Ala Cys Thr Gly Asn Pro Asp Leu Ile Met
     210                 215                 220

 aga gcc cga aaa acc ttt cca tcc aaa gaa gca gct ctc agt gtc tat      720
 Arg Ala Arg Lys Thr Phe Pro Ser Lys Glu Ala Ala Leu Ser Val Tyr
 225                 230                 235                 240

 gca gct atg tat ctg acc atg tac atc acc aac aca atc aaa gcc aag      768
 Ala Ala Met Tyr Leu Thr Met Tyr Ile Thr Asn Thr Ile Lys Ala Lys
                 245                 250                 255

 gga acc aga ctt gct aag cca gtt cta tgc ttg ggc tta atg tgt ttg      816
 Gly Thr Arg Leu Ala Lys Pro Val Leu Cys Leu Gly Leu Met Cys Leu
             260                 265                 270

 gca ttt ctt act gga ctc aac aga gta gca gaa tat cga aat cat tgg      864
 Ala Phe Leu Thr Gly Leu Asn Arg Val Ala Glu Tyr Arg Asn His Trp
         275                 280                 285

 tca gat gtt ata gca ggc ttt ctg gtt gga ata tct ata gca gta ttt      912
 Ser Asp Val Ile Ala Gly Phe Leu Val Gly Ile Ser Ile Ala Val Phe
     290                 295                 300

 ctg gtt gtg tgc gtg gtg aat aat ttc aaa ggg aga caa gca gaa aat      960
 Leu Val Val Cys Val Val Asn Asn Phe Lys Gly Arg Gln Ala Glu Asn
 305                 310                 315                 320

 gag cat ata cac atg gat aat ctg gca cag atg cca atg atc agc att     1008
 Glu His Ile His Met Asp Asn Leu Ala Gln Met Pro Met Ile Ser Ile
                 325                 330                 335

 cct cga gta gaa agt cct ttg gaa aag aac cac atc act gcc ttc gca     1056
 Pro Arg Val Glu Ser Pro Leu Glu Lys Asn His Ile Thr Ala Phe Ala
             340                 345                 350

 gaa gtc aca tga tat cgaagcagat ggtttttcac tgcattggac atcatccctt     1111
 Glu Val Thr 
         355

 tttaccatcc attcataaca cccaaagttt gtttgattgc aag                     1154




      <210> 332
      <211> 2390
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (244)..(2064)

      <400> 332
 gaccgcctcg attccggtcg accccgcgtc cgacagaaag cgctttaagg ttcgtttcat     60

 gcagttggct tgtgggactc tgagagatgc tgctgcccat gacatgcggg aattatcatg    120

 atcaactacc cagcttggat ttcacccagt ggccaagagc tttgtgtggg agacggcaag    180

 ggttggattt ttcaaaagag taaaccagac ccgtgaccaa ggtgtagact aagaagtgga    240

 gtc  atg ctt cac acg gcc ata tca tgc tgg cag cca ttc ctg ggt ctg     288
      Met Leu His Thr Ala Ile Ser Cys Trp Gln Pro Phe Leu Gly Leu
        1               5                  10                  15

 gct gtg gtg tta atc ttc atg gga tcc acc att ggc tgc ccc gct cgc      336
 Ala Val Val Leu Ile Phe Met Gly Ser Thr Ile Gly Cys Pro Ala Arg
                  20                  25                  30

 tgt gag tgc tct gcc cag aac aaa tct gtt agc tgt cac aga agg cga      384
 Cys Glu Cys Ser Ala Gln Asn Lys Ser Val Ser Cys His Arg Arg Arg
              35                  40                  45

 ttg atc gcc atc cca gag ggc att ccc atc gaa acc aaa atc ttg gac      432
 Leu Ile Ala Ile Pro Glu Gly Ile Pro Ile Glu Thr Lys Ile Leu Asp
          50                  55                  60

 ctc agt aaa aac agg cta aaa agc gtc aac cct gaa gaa ttc ata tca      480
 Leu Ser Lys Asn Arg Leu Lys Ser Val Asn Pro Glu Glu Phe Ile Ser
      65                  70                  75

 tat cct ctg ctg gaa gag ata gac ttg agt gac aac atc att gcc aat      528
 Tyr Pro Leu Leu Glu Glu Ile Asp Leu Ser Asp Asn Ile Ile Ala Asn
  80                  85                  90                  95

 gtg gaa cca gga gca ttc aac aat ctc ttt aac ctg cgt tcc ctc cgc      576
 Val Glu Pro Gly Ala Phe Asn Asn Leu Phe Asn Leu Arg Ser Leu Arg
                 100                 105                 110

 cta aaa ggc aat cgt cta aag ctg gtc cct ttg gga gta ttc acg ggg      624
 Leu Lys Gly Asn Arg Leu Lys Leu Val Pro Leu Gly Val Phe Thr Gly
             115                 120                 125

 ctg tcc aat ctc act aag ctt gac att agt gag aat aag att gtc att      672
 Leu Ser Asn Leu Thr Lys Leu Asp Ile Ser Glu Asn Lys Ile Val Ile
         130                 135                 140

 tta cta gac tac atg ttc caa gat cta cat aac ctg aag tct cta gaa      720
 Leu Leu Asp Tyr Met Phe Gln Asp Leu His Asn Leu Lys Ser Leu Glu
     145                 150                 155

 gtg ggg gac aat gat ttg gtt tat ata tca cac agg gca ttc agt ggg      768
 Val Gly Asp Asn Asp Leu Val Tyr Ile Ser His Arg Ala Phe Ser Gly
 160                 165                 170                 175

 ctt ctt agc ttg gag cag ctc acc ctg gag aaa tgc aac tta aca gca      816
 Leu Leu Ser Leu Glu Gln Leu Thr Leu Glu Lys Cys Asn Leu Thr Ala
                 180                 185                 190

 gta cca aca gaa gcc ctc tcc cac ctc cgc agc ctc atc agc ctg cat      864
 Val Pro Thr Glu Ala Leu Ser His Leu Arg Ser Leu Ile Ser Leu His
             195                 200                 205

 ctg aag cat ctc aat atc aac aat atg cct gtg tat gcc ttt aaa aga      912
 Leu Lys His Leu Asn Ile Asn Asn Met Pro Val Tyr Ala Phe Lys Arg
         210                 215                 220

 ttg ttc cac ctg aaa cac cta gag att gac tat tgg cct tta ctg gat      960
 Leu Phe His Leu Lys His Leu Glu Ile Asp Tyr Trp Pro Leu Leu Asp
     225                 230                 235

 atg atg cct gcc aat agc ctc tac ggt ctc aac ctc aca tcc ctt tca     1008
 Met Met Pro Ala Asn Ser Leu Tyr Gly Leu Asn Leu Thr Ser Leu Ser
 240                 245                 250                 255

 gtc acc aac acc aat ctg tct act gta ccc ttc ctt gcc ttt aaa cac     1056
 Val Thr Asn Thr Asn Leu Ser Thr Val Pro Phe Leu Ala Phe Lys His
                 260                 265                 270

 ctg gta tac ctg act cac ctt aac ctc tcc tac aat ccc atc agc act     1104
 Leu Val Tyr Leu Thr His Leu Asn Leu Ser Tyr Asn Pro Ile Ser Thr
             275                 280                 285

 att gaa gca ggc atg ttc tct gac ctg atc cgc ctt cag gag ctt cat     1152
 Ile Glu Ala Gly Met Phe Ser Asp Leu Ile Arg Leu Gln Glu Leu His
         290                 295                 300

 ata gtg ggg gcc cag ctt cgc acc att gag cct cac tcc ttc caa ggg     1200
 Ile Val Gly Ala Gln Leu Arg Thr Ile Glu Pro His Ser Phe Gln Gly
     305                 310                 315

 ctc cgc ttc cta cgc gtg ctc aat gtg tct cag aac ctg ctg gaa act     1248
 Leu Arg Phe Leu Arg Val Leu Asn Val Ser Gln Asn Leu Leu Glu Thr
 320                 325                 330                 335

 ttg gaa gag aat gtc ttc tcc tcc cct agg gct ctg gag gtc ttg agc     1296
 Leu Glu Glu Asn Val Phe Ser Ser Pro Arg Ala Leu Glu Val Leu Ser
                 340                 345                 350

 att aac aac aac cct ctg gcc tgt gac tgc cgc ctt ctc tgg atc ttg     1344
 Ile Asn Asn Asn Pro Leu Ala Cys Asp Cys Arg Leu Leu Trp Ile Leu
             355                 360                 365

 cag cga cag ccc acc ctg cag ttt ggt ggc cag caa cct atg tgt gct     1392
 Gln Arg Gln Pro Thr Leu Gln Phe Gly Gly Gln Gln Pro Met Cys Ala
         370                 375                 380

 ggc cca gac acc atc cgt gag agg tct ttc aag gat ttc cat agc act     1440
 Gly Pro Asp Thr Ile Arg Glu Arg Ser Phe Lys Asp Phe His Ser Thr
     385                 390                 395

 gcc ctt tct ttt tac ttt acc tgc aaa aaa ccc aaa atc cgt gaa aag     1488
 Ala Leu Ser Phe Tyr Phe Thr Cys Lys Lys Pro Lys Ile Arg Glu Lys
 400                 405                 410                 415

 aag ttg cag cat ctg cta gta gat gaa ggg cag aca gtc cag cta gaa     1536
 Lys Leu Gln His Leu Leu Val Asp Glu Gly Gln Thr Val Gln Leu Glu
                 420                 425                 430

 tgc agt gca gat gga gac ccg cag cct gtg att tcc tgg gtg aca ccc     1584
 Cys Ser Ala Asp Gly Asp Pro Gln Pro Val Ile Ser Trp Val Thr Pro
             435                 440                 445

 cga agg cgt ttc atc acc acc aag tcc aat gga aga gcc acc gtg ttg     1632
 Arg Arg Arg Phe Ile Thr Thr Lys Ser Asn Gly Arg Ala Thr Val Leu
         450                 455                 460

 ggt gat ggc acc ttg gaa atc cgc ttt gcc cag gat caa gac agc ggg     1680
 Gly Asp Gly Thr Leu Glu Ile Arg Phe Ala Gln Asp Gln Asp Ser Gly
     465                 470                 475

 atg tat gtt tgc atc gct agc aat gct gct ggg aat gat acc ttc aca     1728
 Met Tyr Val Cys Ile Ala Ser Asn Ala Ala Gly Asn Asp Thr Phe Thr
 480                 485                 490                 495

 gcc tcc tta act gtg aaa gga ttc gct tca gat cgt ttt ctt tat gcg     1776
 Ala Ser Leu Thr Val Lys Gly Phe Ala Ser Asp Arg Phe Leu Tyr Ala
                 500                 505                 510

 aac agg acc cct atg tac atg acc gac tcc aat gac acc att tcc aat     1824
 Asn Arg Thr Pro Met Tyr Met Thr Asp Ser Asn Asp Thr Ile Ser Asn
             515                 520                 525

 ggc acc aat gcc aat act ttt tcc ctg gac ctt aaa aca ata ctg gtg     1872
 Gly Thr Asn Ala Asn Thr Phe Ser Leu Asp Leu Lys Thr Ile Leu Val
         530                 535                 540

 tct aca gct atg ggc tgc ttc aca ttc ctg gga gtg gtt tta ttt tgt     1920
 Ser Thr Ala Met Gly Cys Phe Thr Phe Leu Gly Val Val Leu Phe Cys
     545                 550                 555

 ttt ctt ctc ctt ttt gtg tgg agc cga ggg aaa ggc aag cac aaa aac     1968
 Phe Leu Leu Leu Phe Val Trp Ser Arg Gly Lys Gly Lys His Lys Asn
 560                 565                 570                 575

 agc att gac ctt gag tat gtg ccc aga aaa aac aat ggt gct gtt gtg     2016
 Ser Ile Asp Leu Glu Tyr Val Pro Arg Lys Asn Asn Gly Ala Val Val
                 580                 585                 590

 gaa ggg gag gta gct gga ccc agg agg ttc aac atg aaa atg att tga     2064
 Glu Gly Glu Val Ala Gly Pro Arg Arg Phe Asn Met Lys Met Ile 
             595                 600                 605

 aggcccaccc ctcacattac tgtctctttg tcaatgtggg taatcagtaa gacagtatgg   2124

 cacagtaaat tactagatta agaggcagcc atgtgcagct gcccctgtat caaaagcagg   2184

 gtctatggaa gcaggaggac ttccaatgga gactctccat cgaaaggcag gcaggcaggc   2244

 atgtgtcaga gcccttcaca cagtgggata ctaagtgttt gcgttgcaaa tattggcgtt   2304

 ctggggatct cagtaatgaa cctgaatatt tggctcacac tcacggacaa ttattcagca   2364

 ttttctacca ctgcaaaaaa aaaaaa                                        2390




      <210> 333
      <211> 1976
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1926)

      <400> 333
  atg ggg gag gga aga gga agg gag gtg gga ggc ggg gcc gac caa gag      48
  Met Gly Glu Gly Arg Gly Arg Glu Val Gly Gly Gly Ala Asp Gln Glu
    1               5                  10                  15

 cag gag ctg gag tct gag ccg gtg gtt gca gcg gag gcg gtg atg tcg       96
 Gln Glu Leu Glu Ser Glu Pro Val Val Ala Ala Glu Ala Val Met Ser
              20                  25                  30

 gtg cag gtt gtg tca gcc gcg gct gcc gcc aag gtg cct gag gtg gag      144
 Val Gln Val Val Ser Ala Ala Ala Ala Ala Lys Val Pro Glu Val Glu
          35                  40                  45

 ctg aag gac ctg agc ccc tcc gag gcg gag tcg caa cta gga ctg agc      192
 Leu Lys Asp Leu Ser Pro Ser Glu Ala Glu Ser Gln Leu Gly Leu Ser
      50                  55                  60

 acg gcc gcc gtg ggc gcc atg gcc ccc ccg gcg ggc ggt gga gac cct      240
 Thr Ala Ala Val Gly Ala Met Ala Pro Pro Ala Gly Gly Gly Asp Pro
  65                  70                  75                  80

 gag gct cca gct ccc gcc gcg gag cgg ccc ccg gtc ccc ggc ccg ggc      288
 Glu Ala Pro Ala Pro Ala Ala Glu Arg Pro Pro Val Pro Gly Pro Gly
                  85                  90                  95

 tcg ggg ccc gcc gcc gct ctc agc ccc gcc gcc ggg aag gtg cct cag      336
 Ser Gly Pro Ala Ala Ala Leu Ser Pro Ala Ala Gly Lys Val Pro Gln
             100                 105                 110

 gcg tcg gcc atg aag cgg agc gac cca cat cac cag cac cag cgg cac      384
 Ala Ser Ala Met Lys Arg Ser Asp Pro His His Gln His Gln Arg His
         115                 120                 125

 cgc gac ggc ggc gag gcc ctg gtc agc ccc gac ggc acc gtc acc gag      432
 Arg Asp Gly Gly Glu Ala Leu Val Ser Pro Asp Gly Thr Val Thr Glu
     130                 135                 140

 gcg ccg cgc aca gtc aag aag cag atc cag ttt gct gac cag aag caa      480
 Ala Pro Arg Thr Val Lys Lys Gln Ile Gln Phe Ala Asp Gln Lys Gln
 145                 150                 155                 160

 gaa ttc aac aaa cgt ccc acc aaa att gga cgt cgc tct ttg tct cgt      528
 Glu Phe Asn Lys Arg Pro Thr Lys Ile Gly Arg Arg Ser Leu Ser Arg
                 165                 170                 175

 tcc att tct cag tca tct act gac agc tac agc tca gcg gct tca tat      576
 Ser Ile Ser Gln Ser Ser Thr Asp Ser Tyr Ser Ser Ala Ala Ser Tyr
             180                 185                 190

 aca gat agc tct gat gat gag aca tcg ccc agg gac aag cag caa aag      624
 Thr Asp Ser Ser Asp Asp Glu Thr Ser Pro Arg Asp Lys Gln Gln Lys
         195                 200                 205

 aac tct aag gga agc agt gac ttc tgt gtt aag aac atc aaa cag gca      672
 Asn Ser Lys Gly Ser Ser Asp Phe Cys Val Lys Asn Ile Lys Gln Ala
     210                 215                 220

 gag ttt gga cga aga gaa att gaa att gct gaa caa gaa atg cct gca      720
 Glu Phe Gly Arg Arg Glu Ile Glu Ile Ala Glu Gln Glu Met Pro Ala
 225                 230                 235                 240

 ttg atg gct ttg agg aag aga gct caa gga gaa aag cct ttg gct gga      768
 Leu Met Ala Leu Arg Lys Arg Ala Gln Gly Glu Lys Pro Leu Ala Gly
                 245                 250                 255

 gcc aaa atc gtg ggt tgc aca cac atc act gct cag act gct gtg ctt      816
 Ala Lys Ile Val Gly Cys Thr His Ile Thr Ala Gln Thr Ala Val Leu
             260                 265                 270

 atg gaa act ctg ggt gct ctg ggg gcc cag tgc cga tgg gct gcc tgc      864
 Met Glu Thr Leu Gly Ala Leu Gly Ala Gln Cys Arg Trp Ala Ala Cys
         275                 280                 285

 aac atc tat tcc act ctc aat gaa gtg gct gct gct cta gca gaa agt      912
 Asn Ile Tyr Ser Thr Leu Asn Glu Val Ala Ala Ala Leu Ala Glu Ser
     290                 295                 300

 gga ttt cct gtt ttt gcc tgg aag gga gag tca gaa gat gac ttt tgg      960
 Gly Phe Pro Val Phe Ala Trp Lys Gly Glu Ser Glu Asp Asp Phe Trp
 305                 310                 315                 320

 tgg tgt atc gat aga tgt gtg aat gtg gag ggc tgg cag cca aac atg     1008
 Trp Cys Ile Asp Arg Cys Val Asn Val Glu Gly Trp Gln Pro Asn Met
                 325                 330                 335

 atc ttg gat gat gga ggg gat ctt acc cac tgg att tat aaa aag tat     1056
 Ile Leu Asp Asp Gly Gly Asp Leu Thr His Trp Ile Tyr Lys Lys Tyr
             340                 345                 350

 ccc aac atg ttt aag aaa atc aag ggc ata gta gag gag agt gtt act     1104
 Pro Asn Met Phe Lys Lys Ile Lys Gly Ile Val Glu Glu Ser Val Thr
         355                 360                 365

 gga gtt cac agg ctg tac caa ctg tcc aaa gct ggg aag ctg tgt gtt     1152
 Gly Val His Arg Leu Tyr Gln Leu Ser Lys Ala Gly Lys Leu Cys Val
     370                 375                 380

 cca gcc atg aat gtc aat gac tca gtc acc aaa cag aaa ttt gac aac     1200
 Pro Ala Met Asn Val Asn Asp Ser Val Thr Lys Gln Lys Phe Asp Asn
 385                 390                 395                 400

 ctc tac tgt tgc cgt gaa tca att ctt gat gga ctt aaa agg aca aca     1248
 Leu Tyr Cys Cys Arg Glu Ser Ile Leu Asp Gly Leu Lys Arg Thr Thr
                 405                 410                 415

 gac atg atg ttt ggt gga aag caa gtg gta gtc tgt ggc tat gga gag     1296
 Asp Met Met Phe Gly Gly Lys Gln Val Val Val Cys Gly Tyr Gly Glu
             420                 425                 430

 gtg ggg aaa ggg tgc tgt gct gcc ctg aaa gcc atg ggc tcc att gtg     1344
 Val Gly Lys Gly Cys Cys Ala Ala Leu Lys Ala Met Gly Ser Ile Val
         435                 440                 445

 tat gta act gaa att gac ccc atc tgt gcc ctg caa gcc tgt atg gat     1392
 Tyr Val Thr Glu Ile Asp Pro Ile Cys Ala Leu Gln Ala Cys Met Asp
     450                 455                 460

 gga ttt cga ctg gtg aaa tta aat gag gtc atc cga caa gtg gac att     1440
 Gly Phe Arg Leu Val Lys Leu Asn Glu Val Ile Arg Gln Val Asp Ile
 465                 470                 475                 480

 gtt att acc tgt aca ggt aac aag aat gtg gta acc aga gag cac ttg     1488
 Val Ile Thr Cys Thr Gly Asn Lys Asn Val Val Thr Arg Glu His Leu
                 485                 490                 495

 gac cgt atg aag aat agc tgc atc gtt tgt aac atg gga cat tcc aac     1536
 Asp Arg Met Lys Asn Ser Cys Ile Val Cys Asn Met Gly His Ser Asn
             500                 505                 510

 aca gag att gac gtg gcg agt ctg cgg aca cca gaa ctg acc tgg gag     1584
 Thr Glu Ile Asp Val Ala Ser Leu Arg Thr Pro Glu Leu Thr Trp Glu
         515                 520                 525

 cga gtg aga tct caa gtt gac cat gtg ata tgg cct gat ggc aag agg     1632
 Arg Val Arg Ser Gln Val Asp His Val Ile Trp Pro Asp Gly Lys Arg
     530                 535                 540

 ata gta ctg ctg gca gag ggc cgc ctg ctg aac ctt agc tgc tcc aca     1680
 Ile Val Leu Leu Ala Glu Gly Arg Leu Leu Asn Leu Ser Cys Ser Thr
 545                 550                 555                 560

 gtg cct aca ttt gtg ctc tca atc act gct act act cag gct ctt gcc     1728
 Val Pro Thr Phe Val Leu Ser Ile Thr Ala Thr Thr Gln Ala Leu Ala
                 565                 570                 575

 ttg ata gag ctt tac aat gct cct gag ggt cgc tat aag cag gat gtc     1776
 Leu Ile Glu Leu Tyr Asn Ala Pro Glu Gly Arg Tyr Lys Gln Asp Val
             580                 585                 590

 tac ctg ttg ccc aag aag atg gat gag tat gtg gcc agc cta cac ctg     1824
 Tyr Leu Leu Pro Lys Lys Met Asp Glu Tyr Val Ala Ser Leu His Leu
         595                 600                 605

 cct acc ttt gat gcc cac ttg aca gag ctg aca gat gaa cag gcc aag     1872
 Pro Thr Phe Asp Ala His Leu Thr Glu Leu Thr Asp Glu Gln Ala Lys
     610                 615                 620

 tat ctg gga ctc aac aag aat ggg ccc ttc aag cct aat tac tac agg     1920
 Tyr Leu Gly Leu Asn Lys Asn Gly Pro Phe Lys Pro Asn Tyr Tyr Arg
 625                 630                 635                 640

 tat taa gttcctgtaa ctcaaaccag aatttttaag gaatagaact ccaagccttt      1976
 Tyr 






      <210> 334
      <211> 1823
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (136)..(1476)

      <400> 334
 cggacgcgtg ggcaaagctg tgtgaggagg aggaggaagt gagaggagga gccaggcccc     60

 aggctggccg ggagtggccc ctcacactgg ttctccccac tttctctgcc tgtggcatcg    120

 aaggccccgg gcacc atg gcc cag gcc ctg ggg gag gac ctg gtg cag cct     171
                  Met Ala Gln Ala Leu Gly Glu Asp Leu Val Gln Pro
                    1               5                  10

 ccc gag ctg cag gat gac tcc agc tcc ttg ggg tcc gac tca gag ctc      219
 Pro Glu Leu Gln Asp Asp Ser Ser Ser Leu Gly Ser Asp Ser Glu Leu
          15                  20                  25

 agc ggg cct ggc cca tat cgc cag gcc gac cgc tat gga ttc att ggg      267
 Ser Gly Pro Gly Pro Tyr Arg Gln Ala Asp Arg Tyr Gly Phe Ile Gly
      30                  35                  40

 ggc agc tca gca gag cca ggg ccg ggc cac cca cct gca gac ctc atc      315
 Gly Ser Ser Ala Glu Pro Gly Pro Gly His Pro Pro Ala Asp Leu Ile
  45                  50                  55                  60

 cgc caa cgg gag atg aag tgg gtg gag atg acc tcg cac tgg gag aaa      363
 Arg Gln Arg Glu Met Lys Trp Val Glu Met Thr Ser His Trp Glu Lys
                  65                  70                  75

 acc atg tcc cgg cgg tac aag aag gta aag atg cag tgc cgg aaa ggc      411
 Thr Met Ser Arg Arg Tyr Lys Lys Val Lys Met Gln Cys Arg Lys Gly
              80                  85                  90

 atc ccg tct gcc ctg cgc gcc cga tgc tgg ccc ctg ttg tgt ggg gcc      459
 Ile Pro Ser Ala Leu Arg Ala Arg Cys Trp Pro Leu Leu Cys Gly Ala
          95                 100                 105

 cat gtg tgc cag aag aac agc cct ggc acc tat cag gag ctg gca gag      507
 His Val Cys Gln Lys Asn Ser Pro Gly Thr Tyr Gln Glu Leu Ala Glu
     110                 115                 120

 gcc cct gga gac cca cag tgg atg gag acc att ggc agg gac ctg cac      555
 Ala Pro Gly Asp Pro Gln Trp Met Glu Thr Ile Gly Arg Asp Leu His
 125                 130                 135                 140

 cgt caa ttc cct ctg cac gag atg ttt gtg tcg cct cag ggc cac ggg      603
 Arg Gln Phe Pro Leu His Glu Met Phe Val Ser Pro Gln Gly His Gly
                 145                 150                 155

 cag cag ggg ctc ctg cag gtg ctc aag gcc tac acc ctg tat cga ccg      651
 Gln Gln Gly Leu Leu Gln Val Leu Lys Ala Tyr Thr Leu Tyr Arg Pro
             160                 165                 170

 gag cag ggc tac tgc cag gcc cag ggg ccc gtg gct gct gtg ctg ctc      699
 Glu Gln Gly Tyr Cys Gln Ala Gln Gly Pro Val Ala Ala Val Leu Leu
         175                 180                 185

 atg cac ctg ccc cca gag gag gcc ttc tgg tgc ctg gtg cag atc tgt      747
 Met His Leu Pro Pro Glu Glu Ala Phe Trp Cys Leu Val Gln Ile Cys
     190                 195                 200

 gag gtc tac ctc cct ggg tac tac ggg ccc cac atg gag gct gtg cgg      795
 Glu Val Tyr Leu Pro Gly Tyr Tyr Gly Pro His Met Glu Ala Val Arg
 205                 210                 215                 220

 ctg gac gcc gag gtg ttc atg gcc ctg ctg cgg cgg ctg ctt ccg cac      843
 Leu Asp Ala Glu Val Phe Met Ala Leu Leu Arg Arg Leu Leu Pro His
                 225                 230                 235

 gtg cac aag cac ctg cag cag gtg ggc gtc gga ccc ctg ctg tac ctg      891
 Val His Lys His Leu Gln Gln Val Gly Val Gly Pro Leu Leu Tyr Leu
             240                 245                 250

 ccc gag tgg ttc ctg tgc ctc ttc gcc cgc tcc ctg ccc ttc ccc aca      939
 Pro Glu Trp Phe Leu Cys Leu Phe Ala Arg Ser Leu Pro Phe Pro Thr
         255                 260                 265

 gtg ctg cgt gtc tgg gat gcc ttc ctc agt gag ggt gcc aga gta ctg      987
 Val Leu Arg Val Trp Asp Ala Phe Leu Ser Glu Gly Ala Arg Val Leu
     270                 275                 280

 ttc cgt gtg ggg ctg aca ctg gtg cgc ctg gcg ctg ggc act gca gag     1035
 Phe Arg Val Gly Leu Thr Leu Val Arg Leu Ala Leu Gly Thr Ala Glu
 285                 290                 295                 300

 cag cga ggg gcc tgc cct ggc ctc ctg gag aca ctg gga gcc ctt cga     1083
 Gln Arg Gly Ala Cys Pro Gly Leu Leu Glu Thr Leu Gly Ala Leu Arg
                 305                 310                 315

 gcc atc ccc ccc gcg cag ctg cag gag gag gcc ttc atg tca cag gtg     1131
 Ala Ile Pro Pro Ala Gln Leu Gln Glu Glu Ala Phe Met Ser Gln Val
             320                 325                 330

 cac agc gtg gtg ctg tca gag cgg gac ctg cag cgg gag atc aag gcc     1179
 His Ser Val Val Leu Ser Glu Arg Asp Leu Gln Arg Glu Ile Lys Ala
         335                 340                 345

 cag ctg gcc cag ctg ccc gat tcc gcg ccg gga ccc ccg ccc cgg cca     1227
 Gln Leu Ala Gln Leu Pro Asp Ser Ala Pro Gly Pro Pro Pro Arg Pro
     350                 355                 360

 cag gtc cgc ctc gcc ggg gcc caa gcc atc ttt gag gcc cag cag ctg     1275
 Gln Val Arg Leu Ala Gly Ala Gln Ala Ile Phe Glu Ala Gln Gln Leu
 365                 370                 375                 380

 gca gga gtg cga cga ggc gcc aag cct gag gtg cct cgg att gtg gtg     1323
 Ala Gly Val Arg Arg Gly Ala Lys Pro Glu Val Pro Arg Ile Val Val
                 385                 390                 395

 cag ccc ccg gag gag ccc aga cca ccg cgg cgg aaa ccc cag acc cgc     1371
 Gln Pro Pro Glu Glu Pro Arg Pro Pro Arg Arg Lys Pro Gln Thr Arg
             400                 405                 410

 ggc aag act ttc cat ggg ctc ctg act cgg gcc cgg ggc ccc ccc atc     1419
 Gly Lys Thr Phe His Gly Leu Leu Thr Arg Ala Arg Gly Pro Pro Ile
         415                 420                 425

 gag ggg ccc ccc agg ccc caa cga ggc tcc acc tcc ttc ctg gac acc     1467
 Glu Gly Pro Pro Arg Pro Gln Arg Gly Ser Thr Ser Phe Leu Asp Thr
     430                 435                 440

 cgc ttc tga gaggacc atggacttag tgtcccccag tctcaattgc ctgatggctg     1523
 Arg Phe 
 445

 atgccagccc ggcaaatagg caccgcactt tactcttggg actcggggac ttggcttcct   1583

 tcctggcaag gaccaggcag tggggaagga ggaggtcctc cgtggtacat actgggtcag   1643

 gcactagcat ggaggagggt cacagagtgg ggcacgtgag gacccatgga accgtcctgg   1703

 tgcccaggcc ctcacaagta ccaaagccag caccaaagga gtcagggaag gggttggctg   1763

 agtcaaggga ccccagaggg caccaggaat aaaatcttct tgaacagaaa aaaaaaaaaa   1823




      <210> 335
      <211> 1463
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1409)

      <400> 335
 ggccgggccg ggccggggct gaggccgagc gagccgcggg gcccgcgcag ccccggccgg     60

 agcccacc atg cgg cgg ctg cgg cgc ctg gcg cac ctg gtg ctc ttc tgc     110
          Met Arg Arg Leu Arg Arg Leu Ala His Leu Val Leu Phe Cys
            1               5                  10

 ccc ttc tcc aag cgc ctg cag ggc cgg ctc cca ggc ctc agg gtc cgc      158
 Pro Phe Ser Lys Arg Leu Gln Gly Arg Leu Pro Gly Leu Arg Val Arg
  15                  20                  25                  30

 tgc atc ttc ctg gcc tgg ctg ggc gtc ttt gca ggc agc tgg ctg gtg      206
 Cys Ile Phe Leu Ala Trp Leu Gly Val Phe Ala Gly Ser Trp Leu Val
                  35                  40                  45

 tac gtg cac tac tcg tcc tac tcg gag cgc tgt cgc ggc cat gtc tgc      254
 Tyr Val His Tyr Ser Ser Tyr Ser Glu Arg Cys Arg Gly His Val Cys
              50                  55                  60

 cag gtg gtc att tgt gac cag tac cgc aag ggg atc atc tcg ggc tcc      302
 Gln Val Val Ile Cys Asp Gln Tyr Arg Lys Gly Ile Ile Ser Gly Ser
          65                  70                  75

 gtc tgc cag gac ctg tgt gag ctg cat atg gtg gag tgg agg acc tgc      350
 Val Cys Gln Asp Leu Cys Glu Leu His Met Val Glu Trp Arg Thr Cys
      80                  85                  90

 ctc tcg gtg gcc ccg ggc cag cag tgg gag ggg gat gtc tgc acg gag      398
 Leu Ser Val Ala Pro Gly Gln Gln Trp Glu Gly Asp Val Cys Thr Glu
  95                 100                 105                 110

 gac ctc tgt ggc cct gtc cag gtg tac agc ggg ctc tgg cgg gac aag      446
 Asp Leu Cys Gly Pro Val Gln Val Tyr Ser Gly Leu Trp Arg Asp Lys
                 115                 120                 125

 gat gta acc atc aag tgt ggc att gag gac acc ctc gac tcc aag gcc      494
 Asp Val Thr Ile Lys Cys Gly Ile Glu Asp Thr Leu Asp Ser Lys Ala
             130                 135                 140

 cgg tcg gat gcg gcc ccc cgg cgg gag ctg gta ctg ttt gac aag ccc      542
 Arg Ser Asp Ala Ala Pro Arg Arg Glu Leu Val Leu Phe Asp Lys Pro
         145                 150                 155

 acc cgg ggc acc tcc atc aag gaa ttc cgg gag atg acc ctc agc ttc      590
 Thr Arg Gly Thr Ser Ile Lys Glu Phe Arg Glu Met Thr Leu Ser Phe
     160                 165                 170

 ctc aag gcg aac ctg gga gac ctg cct tcc ctg ccg gcg ctg gtt ggc      638
 Leu Lys Ala Asn Leu Gly Asp Leu Pro Ser Leu Pro Ala Leu Val Gly
 175                 180                 185                 190

 cag gtc ctg ctc atg gct gac ttc aac aag gac aac cgg gtg tcc ctg      686
 Gln Val Leu Leu Met Ala Asp Phe Asn Lys Asp Asn Arg Val Ser Leu
                 195                 200                 205

 gcg gaa gcc aag tcc gtg tgg gcc ctg ctg cag cgt aac gag ttc ctg      734
 Ala Glu Ala Lys Ser Val Trp Ala Leu Leu Gln Arg Asn Glu Phe Leu
             210                 215                 220

 ctg ctg ctg tcc ctg cag gag aag gag cac gcc tcc aga ctg ctg ggc      782
 Leu Leu Leu Ser Leu Gln Glu Lys Glu His Ala Ser Arg Leu Leu Gly
         225                 230                 235

 tac tgt ggg gac ctc tac ctc acc gag ggc gtg ccg cat ggc gcc tgg      830
 Tyr Cys Gly Asp Leu Tyr Leu Thr Glu Gly Val Pro His Gly Ala Trp
     240                 245                 250

 cac gcg gcc gcc ctt cca ccc ctg ttg cgc cca ctg ctg ccg cct gcc      878
 His Ala Ala Ala Leu Pro Pro Leu Leu Arg Pro Leu Leu Pro Pro Ala
 255                 260                 265                 270

 ctg cag ggt gct ctc cag cag tgg ctg ggg cct gcg tgg cct tgg cgg      926
 Leu Gln Gly Ala Leu Gln Gln Trp Leu Gly Pro Ala Trp Pro Trp Arg
                 275                 280                 285

 gcc aag atc gcc atc ggc ctg ctg gag ttc gtg gag gag ctc ttc cac      974
 Ala Lys Ile Ala Ile Gly Leu Leu Glu Phe Val Glu Glu Leu Phe His
             290                 295                 300

 ggc tct tac ggg act ttc tac atg tgt gag acc aca ctg gcc aac gtg     1022
 Gly Ser Tyr Gly Thr Phe Tyr Met Cys Glu Thr Thr Leu Ala Asn Val
         305                 310                 315

 ggc tac aca gcc acc tac gac ttc aag atg gcc gac ctg cag cag gtg     1070
 Gly Tyr Thr Ala Thr Tyr Asp Phe Lys Met Ala Asp Leu Gln Gln Val
     320                 325                 330

 gca ccc gag gcc acc gtg cgc cgc ttc ctg cag ggc cgc cgc tgc gag     1118
 Ala Pro Glu Ala Thr Val Arg Arg Phe Leu Gln Gly Arg Arg Cys Glu
 335                 340                 345                 350

 cac agc acc gac tgc acc tac ggg cgc gac tgc agg gcc ccg tgt gac     1166
 His Ser Thr Asp Cys Thr Tyr Gly Arg Asp Cys Arg Ala Pro Cys Asp
                 355                 360                 365

 agg ctc atg agg cag tgc aag ggc gac ctc atc cag ccc aac ctg gcc     1214
 Arg Leu Met Arg Gln Cys Lys Gly Asp Leu Ile Gln Pro Asn Leu Ala
             370                 375                 380

 aag gtg tgc gca ctg cta cgg ggc tac ctg ctg cct ggc gcg ccc gcc     1262
 Lys Val Cys Ala Leu Leu Arg Gly Tyr Leu Leu Pro Gly Ala Pro Ala
         385                 390                 395

 gac ctc cgc gag gag ctg ggc aca cag ctg cgc acc tgt acc acg ctg     1310
 Asp Leu Arg Glu Glu Leu Gly Thr Gln Leu Arg Thr Cys Thr Thr Leu
     400                 405                 410

 agc ggg ctg gcc agc cag gtg gag gcc cat cac tcg ctg gtg ctc agc     1358
 Ser Gly Leu Ala Ser Gln Val Glu Ala His His Ser Leu Val Leu Ser
 415                 420                 425                 430

 cac ctc aag act ctg ctc tgg aag aag atc tcc aac acc aag tac tct     1406
 His Leu Lys Thr Leu Leu Trp Lys Lys Ile Ser Asn Thr Lys Tyr Ser
                 435                 440                 445

 tga tggg gcagtgaggg gcctggccac ccttcctgga gctggccagg tgccagggtc     1463
 






      <210> 336
      <211> 1414
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (69)..(1364)

      <400> 336
 ggccgggccg ggccggggct gaggccgagc gagccgcggg gcccgcgcag ccccggccgg     60

 agcccacc atg cgg cgg ctg cgg cgc ctg gcg cac ctg gtg ctc ttc tgc     110
          Met Arg Arg Leu Arg Arg Leu Ala His Leu Val Leu Phe Cys
            1               5                  10

 ccc ttc tcc aag cgc ctg cag ggc cgg ctc cca ggc ctc agg gtc cgc      158
 Pro Phe Ser Lys Arg Leu Gln Gly Arg Leu Pro Gly Leu Arg Val Arg
  15                  20                  25                  30

 tgc atc ttc ctg gcc tgg ctg ggc gtc ttt gca ggc agc tgg ctg gtg      206
 Cys Ile Phe Leu Ala Trp Leu Gly Val Phe Ala Gly Ser Trp Leu Val
                  35                  40                  45

 tac gtg cac tac tcg tcc tac tcg gag cgc tgt cgc ggc cat gtc tgc      254
 Tyr Val His Tyr Ser Ser Tyr Ser Glu Arg Cys Arg Gly His Val Cys
              50                  55                  60

 cag gtg gtc att tgt gac cag tac cgc aag ggg atc atc tcg ggc tcc      302
 Gln Val Val Ile Cys Asp Gln Tyr Arg Lys Gly Ile Ile Ser Gly Ser
          65                  70                  75

 gtc tgc cag gac ctg tgt gag ctg cat atg gtg gag tgg agg acc tgc      350
 Val Cys Gln Asp Leu Cys Glu Leu His Met Val Glu Trp Arg Thr Cys
      80                  85                  90

 ctc tcg gtg gcc ccg ggc cag cag gtg tac agc ggg ctc tgg cgg gac      398
 Leu Ser Val Ala Pro Gly Gln Gln Val Tyr Ser Gly Leu Trp Arg Asp
  95                 100                 105                 110

 aag gat gta acc atc aag tgt ggc att gag gac acc ctc gac tcc aag      446
 Lys Asp Val Thr Ile Lys Cys Gly Ile Glu Asp Thr Leu Asp Ser Lys
                 115                 120                 125

 gcc cgg tcg gat gcg gcc ccc cgg cgg gag ctg gta ctg ttt gac aag      494
 Ala Arg Ser Asp Ala Ala Pro Arg Arg Glu Leu Val Leu Phe Asp Lys
             130                 135                 140

 ccc acc cgg ggc acc tcc atc aag gaa ttc cgg gag atg acc ctc agc      542
 Pro Thr Arg Gly Thr Ser Ile Lys Glu Phe Arg Glu Met Thr Leu Ser
         145                 150                 155

 ttc ctc aag gcg aac ctg gga gac ctg cct tcc ctg ccg gcg ctg gtt      590
 Phe Leu Lys Ala Asn Leu Gly Asp Leu Pro Ser Leu Pro Ala Leu Val
     160                 165                 170

 ggc cag gtc ctg ctc atg gct gac ttc aac aag gac aac cgg gtg tcc      638
 Gly Gln Val Leu Leu Met Ala Asp Phe Asn Lys Asp Asn Arg Val Ser
 175                 180                 185                 190

 ctg gcg gaa gcc aag tcc gtg tgg gcc ctg ctg cag cgt aac gag ttc      686
 Leu Ala Glu Ala Lys Ser Val Trp Ala Leu Leu Gln Arg Asn Glu Phe
                 195                 200                 205

 ctg ctg ctg ctg tcc ctg cag gag aag gag cac gcc tcc aga ctg ctg      734
 Leu Leu Leu Leu Ser Leu Gln Glu Lys Glu His Ala Ser Arg Leu Leu
             210                 215                 220

 ggc tac tgt ggg gac ctc tac ctc acc gag ggc gtg ccg cat ggc gcc      782
 Gly Tyr Cys Gly Asp Leu Tyr Leu Thr Glu Gly Val Pro His Gly Ala
         225                 230                 235

 tgg cac gcg gcc gcc ctt cca ccc ctg ttg cgc cca ctg ctg ccg cct      830
 Trp His Ala Ala Ala Leu Pro Pro Leu Leu Arg Pro Leu Leu Pro Pro
     240                 245                 250

 gcc ctg cag ggt gct ctc cag cag tgg ctg ggg cct gcg tgg cct tgg      878
 Ala Leu Gln Gly Ala Leu Gln Gln Trp Leu Gly Pro Ala Trp Pro Trp
 255                 260                 265                 270

 cgg gcc aag atc gcc atc ggc ctg ctg gag ttc gtg gag gag ctc ttc      926
 Arg Ala Lys Ile Ala Ile Gly Leu Leu Glu Phe Val Glu Glu Leu Phe
                 275                 280                 285

 cac ggc tct tac ggg act ttc tac atg tgt gag acc aca ctg gcc aac      974
 His Gly Ser Tyr Gly Thr Phe Tyr Met Cys Glu Thr Thr Leu Ala Asn
             290                 295                 300

 gtg ggc tac aca gcc acc tac gac ttc aag atg gcc gac ctg cag cag     1022
 Val Gly Tyr Thr Ala Thr Tyr Asp Phe Lys Met Ala Asp Leu Gln Gln
         305                 310                 315

 gtg gca ccc gag gcc acc gtg cgc cgc ttc ctg cag ggc cgc cgc tgc     1070
 Val Ala Pro Glu Ala Thr Val Arg Arg Phe Leu Gln Gly Arg Arg Cys
     320                 325                 330

 gag cac agc acc gac tgc acc tac ggg cgc gac tgc agg gcc ccg tgt     1118
 Glu His Ser Thr Asp Cys Thr Tyr Gly Arg Asp Cys Arg Ala Pro Cys
 335                 340                 345                 350

 gac agg ctc atg agg cag tgc aag ggc gac ctc atc cag ccc aac ctg     1166
 Asp Arg Leu Met Arg Gln Cys Lys Gly Asp Leu Ile Gln Pro Asn Leu
                 355                 360                 365

 gcc aag gtg tgc gca ctg cta cgg ggc tac ctg ctg cct ggc gcg ccc     1214
 Ala Lys Val Cys Ala Leu Leu Arg Gly Tyr Leu Leu Pro Gly Ala Pro
             370                 375                 380

 gcc gac ctc cgc gag gag ctg ggc aca cag ctg cgc acc tgt acc acg     1262
 Ala Asp Leu Arg Glu Glu Leu Gly Thr Gln Leu Arg Thr Cys Thr Thr
         385                 390                 395

 ctg agc ggg ctg gcc agc cag gtg gag gcc cat cac tcg ctg gtg ctc     1310
 Leu Ser Gly Leu Ala Ser Gln Val Glu Ala His His Ser Leu Val Leu
     400                 405                 410

 agc cac ctc aag act ctg ctc tgg aag aag atc tcc aac acc aag tac     1358
 Ser His Leu Lys Thr Leu Leu Trp Lys Lys Ile Ser Asn Thr Lys Tyr
 415                 420                 425                 430

 tct tga tggggcagtg aggggcctgg ccacccttcc tggagctggc caggtgccag      1414
 Ser 






      <210> 337
      <211> 2283
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (438)..(1904)

      <400> 337
 ttcctgctgc tgaccaccct cttgctgctg attggtgtgg tctgtgcctt tgtcaccaac     60

 cagcgcacgc atgaacagat gggccccagc atcgaggcca tgcctgagac cctgctcagc    120

 ctctggggcc tggtctctga tgtcccccaa gtgttggtgt gagcattggg agcgcgatcc    180

 acactcagct caggagctcc gtgtacccct tgcttggcgg ccgtgggcag tttgggccag    240

 gtcctgcagg tctccgtgca ccacctgcaa accttgaatg ctacagtggt agagctgcag    300

 gccgggcagc aggacctgga gccagccatc cgggaacacc gggaccgcct ccttgagctg    360

 ctgcaggagg ccaggtgccc tctgtggacc atgtcctgca ccagctaaaa ggtgtccccg    420

 aggccaactt ctccagc   atg gtc cag gag gag aac agc acc ttc aac gcc     470
                      Met Val Gln Glu Glu Asn Ser Thr Phe Asn Ala
                        1               5                  10

 ctt cca gcc ctg gct gcc atg cag aca tcc agc gtg gtg caa gag ctg      518
 Leu Pro Ala Leu Ala Ala Met Gln Thr Ser Ser Val Val Gln Glu Leu
              15                  20                  25

 aag aag gca gtg gcc cag cag ccg gaa ggg gtg agg aca ctg gct gaa      566
 Lys Lys Ala Val Ala Gln Gln Pro Glu Gly Val Arg Thr Leu Ala Glu
          30                  35                  40

 ggg ttc ccg ggc ttg gag gca gct tcc cgc tgg gcc cag gca ctg cag      614
 Gly Phe Pro Gly Leu Glu Ala Ala Ser Arg Trp Ala Gln Ala Leu Gln
      45                  50                  55

 gag gtg gag gag agc agc cgc ccc tac ctg cag gag gtg cag aga tac      662
 Glu Val Glu Glu Ser Ser Arg Pro Tyr Leu Gln Glu Val Gln Arg Tyr
  60                  65                  70                  75

 gag acc tac agg tgg atc gtg ggc tgc gtg ctg tgc tcc gtg gtc cta      710
 Glu Thr Tyr Arg Trp Ile Val Gly Cys Val Leu Cys Ser Val Val Leu
                  80                  85                  90

 ttc gtg gtg ctc tgc aac ctg ctg ggc ctc aat ctg ggc atc tgg ggc      758
 Phe Val Val Leu Cys Asn Leu Leu Gly Leu Asn Leu Gly Ile Trp Gly
              95                 100                 105

 ctg tct gcc agg gac gac ccc agc cac cca gaa gcc aag ggc gag gct      806
 Leu Ser Ala Arg Asp Asp Pro Ser His Pro Glu Ala Lys Gly Glu Ala
         110                 115                 120

 gga gcc cgc ttc ctc atg gca ggt gtg ggc ctc agc ttc ctc ttt gct      854
 Gly Ala Arg Phe Leu Met Ala Gly Val Gly Leu Ser Phe Leu Phe Ala
     125                 130                 135

 gca ccc ctc atc ctc ctg gtg ttc gcc acc ttc ctg gtg ggt ggc aac      902
 Ala Pro Leu Ile Leu Leu Val Phe Ala Thr Phe Leu Val Gly Gly Asn
 140                 145                 150                 155

 gtg cag acg ctg gtg tgc cag agc tgg gag aac agc gag ctc ttt gag      950
 Val Gln Thr Leu Val Cys Gln Ser Trp Glu Asn Ser Glu Leu Phe Glu
                 160                 165                 170

 ttt gca gac acc cca ggg aac ctg ccc ccg tcc atg aac ctg tcg caa      998
 Phe Ala Asp Thr Pro Gly Asn Leu Pro Pro Ser Met Asn Leu Ser Gln
             175                 180                 185

 ctt ctt ggc ctg agg aag aac atc agc atc cac caa gcc tat cag cag     1046
 Leu Leu Gly Leu Arg Lys Asn Ile Ser Ile His Gln Ala Tyr Gln Gln
         190                 195                 200

 tgc aag gaa ggg gca gcg ctc tgg aca gtc ctg cag ctc aac gac tcc     1094
 Cys Lys Glu Gly Ala Ala Leu Trp Thr Val Leu Gln Leu Asn Asp Ser
     205                 210                 215

 tac gac ctg gag gag cac ctg gat atc aac cag tat acc aac aag cta     1142
 Tyr Asp Leu Glu Glu His Leu Asp Ile Asn Gln Tyr Thr Asn Lys Leu
 220                 225                 230                 235

 cgg cag gag ttg cag agc ctg aaa gta gac aca cag agc ctg gac ctg     1190
 Arg Gln Glu Leu Gln Ser Leu Lys Val Asp Thr Gln Ser Leu Asp Leu
                 240                 245                 250

 ctg agc tca gcc gcc cgc cgg gac ctg gag gcc ctg cag agc agt ggg     1238
 Leu Ser Ser Ala Ala Arg Arg Asp Leu Glu Ala Leu Gln Ser Ser Gly
             255                 260                 265

 ctt cag cgc atc cac tac ccc gac ttc ctc gtt cag atc cag agg ccc     1286
 Leu Gln Arg Ile His Tyr Pro Asp Phe Leu Val Gln Ile Gln Arg Pro
         270                 275                 280

 gtg gtg aag acc agc atg gag cag ctg gcc cag gag ctg caa gga ctg     1334
 Val Val Lys Thr Ser Met Glu Gln Leu Ala Gln Glu Leu Gln Gly Leu
     285                 290                 295

 gcc cag gcc caa gac aat tct gtg ctg ggg cag cgg ctg cag gag gag     1382
 Ala Gln Ala Gln Asp Asn Ser Val Leu Gly Gln Arg Leu Gln Glu Glu
 300                 305                 310                 315

 gcc caa gga ctc aga aac ctt cac cag gag aag gtc gtc ccc cag cag     1430
 Ala Gln Gly Leu Arg Asn Leu His Gln Glu Lys Val Val Pro Gln Gln
                 320                 325                 330

 agc ctt gtg gca aag ctc aac ctc agc gtc agg gcc ctg gag tcc tct     1478
 Ser Leu Val Ala Lys Leu Asn Leu Ser Val Arg Ala Leu Glu Ser Ser
             335                 340                 345

 gcc ccg aat ctc cag ctg gag acc tca gat gtc cta gcc aat gtc acc     1526
 Ala Pro Asn Leu Gln Leu Glu Thr Ser Asp Val Leu Ala Asn Val Thr
         350                 355                 360

 tac ctg aaa gga gag ctg cct gcc tgg gca gcc agg atc ctg agg aat     1574
 Tyr Leu Lys Gly Glu Leu Pro Ala Trp Ala Ala Arg Ile Leu Arg Asn
     365                 370                 375

 gtg agt gag tgt ttc ctg gcc cgg gag atg ggc tac ttc tcc cag tac     1622
 Val Ser Glu Cys Phe Leu Ala Arg Glu Met Gly Tyr Phe Ser Gln Tyr
 380                 385                 390                 395

 gtg gcc tgg gtg aga gag gag gtg act cag cgc att gcc acc tgc cag     1670
 Val Ala Trp Val Arg Glu Glu Val Thr Gln Arg Ile Ala Thr Cys Gln
                 400                 405                 410

 ccc ctc tcc gga gcc ctg gac aac agc cgt gtg atc ctg tgt gac atg     1718
 Pro Leu Ser Gly Ala Leu Asp Asn Ser Arg Val Ile Leu Cys Asp Met
             415                 420                 425

 atg gct gac ccc tgg aat gcc ttc tgg ttc tgc ctg gca tgg tgc acc     1766
 Met Ala Asp Pro Trp Asn Ala Phe Trp Phe Cys Leu Ala Trp Cys Thr
         430                 435                 440

 ttc ttc ctg atc ccc agc atc atc ttt gcc gtc aag acc tcc aaa tac     1814
 Phe Phe Leu Ile Pro Ser Ile Ile Phe Ala Val Lys Thr Ser Lys Tyr
     445                 450                 455

 ttc cgt cct atc cgg aaa cgc ctc agc tcc acc agc tct gag gag act     1862
 Phe Arg Pro Ile Arg Lys Arg Leu Ser Ser Thr Ser Ser Glu Glu Thr
 460                 465                 470                 475

 cag ctc ttc cac atc ccc cgg gtt acc tcc ctg aag ctg tag ggccttg     1911
 Gln Leu Phe His Ile Pro Arg Val Thr Ser Leu Lys Leu 
                 480                 485

 tgggtgggtt ttccccaact cgcttaattg ctccctgcca gggattaagg gagtggggtg   1971

 gggaggggct ggggtctggg gtttccaggg cctaggaggg caggaaggct tggggacatg   2031

 gtggagtctg ggtattgggt gtggcccatc cagcagtggg gctgacagcc ctgttctccc   2091

 ctccctcccc ttcacccgtt tccttcttaa tccctgacag ggtgaggtga ccctgaggct   2151

 gcctgtcctc ccctttgatt tagcctgggc cacaggactt cggtagctct tgccccagag   2211

 cccaggctgg catccaggcc tggactgtcc ccagttccgg cttacctggc cccaccttgc   2271

 ctgctccttt cc                                                       2283




      <210> 338
      <211> 1756
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (575)..(1354)

      <400> 338
 cgaaatcatt cttttattcc tgatcctgtt tcctgtttat ttcatgaact tgtctgtagg     60

 cagcatggtg ctgggcgctg caggtgctca tgaatgcatg agacacagat tccactcagg    120

 agagagaaga cgaacacaga cacagtacac ggtgggaagg ggcacttcca tgtctgcagc    180

 cagagagccc tttcagaatc tgacccaaaa gatggccagt attctaagaa aaagcacata    240

 tgcttacgat gtgcaaacag ctgaaggtgt tctttcaact atagtaaaag gggtgtctcg    300

 gtggccacag gcggcccaga tgaaggtgct gctggggaaa atgtcaccac gctggtcttg    360

 ggaggctcca tgagagggag gtgggacttg agaggggctt acagcctggg tgagaggcaa    420

 agaggaggcc agagaccttc tgggtagaga ggaccctcgg gccaaggctc agaggtggat    480

 gaacggggga gccttaggtg gaacagcaca gggtggaacc cggcagagga caatgggagc    540

 tgatggaggc taggccagag tggggccttc agtg    atg ctt gaa ccc cag gct     592
                                          Met Leu Glu Pro Gln Ala
                                            1               5

 tca gac tcc aga aga gcc aag ggc agg tgg ccc ggc tgc aga gcc tgt      640
 Ser Asp Ser Arg Arg Ala Lys Gly Arg Trp Pro Gly Cys Arg Ala Cys
              10                  15                  20

 ggc agg cag gcc tca ctc act ata ccc ttc tgt gtc ctt tgc ctg cag      688
 Gly Arg Gln Ala Ser Leu Thr Ile Pro Phe Cys Val Leu Cys Leu Gln
          25                  30                  35

 aga cct gtc tgg gcc gca gag agg agt ctg gag gta ggg tcc aag ggc      736
 Arg Pro Val Trp Ala Ala Glu Arg Ser Leu Glu Val Gly Ser Lys Gly
      40                  45                  50

 cac gag cca gtt tgg gct gct gga ggg ggg cct ggc aag gag ggc tct      784
 His Glu Pro Val Trp Ala Ala Gly Gly Gly Pro Gly Lys Glu Gly Ser
  55                  60                  65                  70

 cgg gga agc acc tgt ggg ggt ctg ctt cct gac ccc agg gag cta gag      832
 Arg Gly Ser Thr Cys Gly Gly Leu Leu Pro Asp Pro Arg Glu Leu Glu
                  75                  80                  85

 gcc tcc ctc cct cca ggc ccc ccg agc cag gct gag cca gcc gct agg      880
 Ala Ser Leu Pro Pro Gly Pro Pro Ser Gln Ala Glu Pro Ala Ala Arg
              90                  95                 100

 ggc acg gag cag tgc cca cct tgc gcc cag tgt ggc cag agc ttc ggc      928
 Gly Thr Glu Gln Cys Pro Pro Cys Ala Gln Cys Gly Gln Ser Phe Gly
         105                 110                 115

 cag aag gag ctc agt gcg ccg cac cag cgc gtg cat cgt ggc ccc cgg      976
 Gln Lys Glu Leu Ser Ala Pro His Gln Arg Val His Arg Gly Pro Arg
     120                 125                 130

 cct ttc gct ggt gct cag tgt ccc aag agc ttc acg cag cgg acc acc     1024
 Pro Phe Ala Gly Ala Gln Cys Pro Lys Ser Phe Thr Gln Arg Thr Thr
 135                 140                 145                 150

 ccc gcc agc cac cgt cgg gcg cac gtg gcc gag tgc acc tac acc cgc     1072
 Pro Ala Ser His Arg Arg Ala His Val Ala Glu Cys Thr Tyr Thr Arg
                 155                 160                 165

 gcc caa tgc ggc aag acc ttc ctc cag cag tcg acg ctc aca ccc act     1120
 Ala Gln Cys Gly Lys Thr Phe Leu Gln Gln Ser Thr Leu Thr Pro Thr
             170                 175                 180

 act gcg cgc aca tca ggg aga agc cct acg agt gcg cca agc tct ttg     1168
 Thr Ala Arg Thr Ser Gly Arg Ser Pro Thr Ser Ala Pro Ser Ser Leu
         185                 190                 195

 gcc gcc tgt cca cgc tgc tgg agc acc ggc aca tgc aca cgg gtg agc     1216
 Ala Ala Cys Pro Arg Cys Trp Ser Thr Gly Thr Cys Thr Arg Val Ser
     200                 205                 210

 ggc cct tcc agt gca cgc aat gtg gct gct gct tca gcc gcc tgt cca     1264
 Gly Pro Ser Ser Ala Arg Asn Val Ala Ala Ala Ser Ala Ala Cys Pro
 215                 220                 225                 230

 cgc tgc tgg agc acc ggc aca cac aca tca gcg aga agc cct tcc agt     1312
 Arg Cys Trp Ser Thr Gly Thr His Thr Ser Ala Arg Ser Pro Ser Ser
                 235                 240                 245

 gtg cgc agt gcg aca agc gtt tca cgc gtc tgg cca acc tga ccgtgca     1361
 Val Arg Ser Ala Thr Ser Val Ser Arg Val Trp Pro Thr 
             250                 255

 ccagagagtg cacttgggcg agcgctcctt ccagtgcgcc cagtacagca ggagattcat   1421

 gcagaagccc ggcttcctgc gtcatctgtg tggccactcg caggagaagc actatccttg   1481

 cagcccttgt ggttcccatg atcagtggtg aaatatagtg attttcacct gtgcttccat   1541

 tctgaagttc tggaaagaag tactggatgg actgaagtcc aggacaacgt cccaaagaaa   1601

 ggcagagtcc aggtaggctt ggaggaccaa gccctggatg agcactggag ggcagaggcc   1661

 tcagtgtcca gcactgtgcc ctgcacatgg aaagccccta cgtttgtgga atgaatgaat   1721

 aataaaaatg ttttcataag tgaaaaaaaa aaaaa                              1756




      <210> 339
      <211> 4184
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(4137)

      <400> 339
  atg gca agc agc ccc acc aaa ggg ttg aca atg agc gtc cca gtg gct      48
  Met Ala Ser Ser Pro Thr Lys Gly Leu Thr Met Ser Val Pro Val Ala
    1               5                  10                  15

 cct aag aaa tca tgt tac act cag ttg cgg gac aac aga aat gca gca       96
 Pro Lys Lys Ser Cys Tyr Thr Gln Leu Arg Asp Asn Arg Asn Ala Ala
              20                  25                  30

 aga aat aat aat gaa agc atc tta agt ctg gga gat acg aat gcc aat      144
 Arg Asn Asn Asn Glu Ser Ile Leu Ser Leu Gly Asp Thr Asn Ala Asn
          35                  40                  45

 caa atc atg ttg gag gtc agc tcc tct cat gac gag tcc aag aca tgt      192
 Gln Ile Met Leu Glu Val Ser Ser Ser His Asp Glu Ser Lys Thr Cys
      50                  55                  60

 gac ctg gga gat gaa att gga aat aca aat tca agt gag cca gaa aac      240
 Asp Leu Gly Asp Glu Ile Gly Asn Thr Asn Ser Ser Glu Pro Glu Asn
  65                  70                  75                  80

 cgt acc cat ttc cat aag gaa ttt cac caa ctt cag ggc ttt ggg aaa      288
 Arg Thr His Phe His Lys Glu Phe His Gln Leu Gln Gly Phe Gly Lys
                  85                  90                  95

 ggc tct cag gct ggc tct gcc agc ctg aaa gat ttt aga ctt tct tca      336
 Gly Ser Gln Ala Gly Ser Ala Ser Leu Lys Asp Phe Arg Leu Ser Ser
             100                 105                 110

 acc att cag agg gaa ctc aat gaa gag cac aca gtg gag aga ggc aca      384
 Thr Ile Gln Arg Glu Leu Asn Glu Glu His Thr Val Glu Arg Gly Thr
         115                 120                 125

 gat agc ctg cag acc acg cgg agt att cag gga cca agt ctg tcg agt      432
 Asp Ser Leu Gln Thr Thr Arg Ser Ile Gln Gly Pro Ser Leu Ser Ser
     130                 135                 140

 tgg agg aat gtg atg agt gag gcc agt cta gac gtt ttg gct aaa agg      480
 Trp Arg Asn Val Met Ser Glu Ala Ser Leu Asp Val Leu Ala Lys Arg
 145                 150                 155                 160

 gat gct gaa att ccc cgg cat gtt ccc aag gat aaa ctg gca aag acc      528
 Asp Ala Glu Ile Pro Arg His Val Pro Lys Asp Lys Leu Ala Lys Thr
                 165                 170                 175

 ctt gac aat gag gaa ctg agg agg cat tct ttg gaa aga gca agc agc      576
 Leu Asp Asn Glu Glu Leu Arg Arg His Ser Leu Glu Arg Ala Ser Ser
             180                 185                 190

 tct gta gct gca gtc ggg agc ctg act ccg cag cat cca cag cct cta      624
 Ser Val Ala Ala Val Gly Ser Leu Thr Pro Gln His Pro Gln Pro Leu
         195                 200                 205

 tcc ctc gac tcc cgg gaa gca cgg ggt cag ata cct ggg ggt ggg gag      672
 Ser Leu Asp Ser Arg Glu Ala Arg Gly Gln Ile Pro Gly Gly Gly Glu
     210                 215                 220

 ggg cca cag aag aca ttg cca gac cac gct gtc ccg gca gct ttc cct      720
 Gly Pro Gln Lys Thr Leu Pro Asp His Ala Val Pro Ala Ala Phe Pro
 225                 230                 235                 240

 gca act gac agt acc tca gag gga aag agt gtg cgt cat cct aaa cca      768
 Ala Thr Asp Ser Thr Ser Glu Gly Lys Ser Val Arg His Pro Lys Pro
                 245                 250                 255

 tct acc tca gaa agc aag cag agc act ccc tca gag acc caa aca gtg      816
 Ser Thr Ser Glu Ser Lys Gln Ser Thr Pro Ser Glu Thr Gln Thr Val
             260                 265                 270

 ggg gca cat gta ctg cag gtg tgc agt gag cac aca tca cat tcc gcc      864
 Gly Ala His Val Leu Gln Val Cys Ser Glu His Thr Ser His Ser Ala
         275                 280                 285

 cat cca gag cct gct ctg aat ttg act ttg gca tcg aag gaa atc cca      912
 His Pro Glu Pro Ala Leu Asn Leu Thr Leu Ala Ser Lys Glu Ile Pro
     290                 295                 300

 agt aaa ctg gaa gca caa tta ggt cag gga aag gga gag gcc aag ctg      960
 Ser Lys Leu Glu Ala Gln Leu Gly Gln Gly Lys Gly Glu Ala Lys Leu
 305                 310                 315                 320

 gat ctg aaa tat gtt cct ccc agg aga gtt gaa cag gag gga aag gca     1008
 Asp Leu Lys Tyr Val Pro Pro Arg Arg Val Glu Gln Glu Gly Lys Ala
                 325                 330                 335

 gcc cag gaa ggg tat ctg gga tgc cac aag gaa gag aat ctg tca gcc     1056
 Ala Gln Glu Gly Tyr Leu Gly Cys His Lys Glu Glu Asn Leu Ser Ala
             340                 345                 350

 ttg gag gga agg gat cca tgt ggg gaa gca cac ccg gaa gcc acc gat     1104
 Leu Glu Gly Arg Asp Pro Cys Gly Glu Ala His Pro Glu Ala Thr Asp
         355                 360                 365

 gca ctt ggc cat ctg ctg aac agt gac ctc cac cac ctt ggg gtg gga     1152
 Ala Leu Gly His Leu Leu Asn Ser Asp Leu His His Leu Gly Val Gly
     370                 375                 380

 aga ggc aac tgt gaa gag aag aga gga gtc aac cca ggg gag cag gat     1200
 Arg Gly Asn Cys Glu Glu Lys Arg Gly Val Asn Pro Gly Glu Gln Asp
 385                 390                 395                 400

 tct ctc cac acc acc ccc aaa cag ggc tct gct tcc tta gga ggg gct     1248
 Ser Leu His Thr Thr Pro Lys Gln Gly Ser Ala Ser Leu Gly Gly Ala
                 405                 410                 415

 gat aat cag ccc act ggc aaa att tca cca tgt gca ggt gag aag ttg     1296
 Asp Asn Gln Pro Thr Gly Lys Ile Ser Pro Cys Ala Gly Glu Lys Leu
             420                 425                 430

 ggt gaa agg aca tcc agc agc ttt tca cca ggt gac agt cat gtg gct     1344
 Gly Glu Arg Thr Ser Ser Ser Phe Ser Pro Gly Asp Ser His Val Ala
         435                 440                 445

 ttt att cct aat aat ctg act gac agc aag ccc ttg gat gtc att gag     1392
 Phe Ile Pro Asn Asn Leu Thr Asp Ser Lys Pro Leu Asp Val Ile Glu
     450                 455                 460

 gag gaa agg cgg ttg ggc agt ggg aat aag gac agt gtt atg gtt ttg     1440
 Glu Glu Arg Arg Leu Gly Ser Gly Asn Lys Asp Ser Val Met Val Leu
 465                 470                 475                 480

 gtg ttc aat cct tct gtt gga gag aac aag acg gag gtg cct gag tcc     1488
 Val Phe Asn Pro Ser Val Gly Glu Asn Lys Thr Glu Val Pro Glu Ser
                 485                 490                 495

 ctg gac cct caa agt ggc cgc tca gaa gca cgg gaa agc aaa gag gtc     1536
 Leu Asp Pro Gln Ser Gly Arg Ser Glu Ala Arg Glu Ser Lys Glu Val
             500                 505                 510

 acc aca tct gtt gct gaa aac agg aac ctt cta gag aat gca gat aag     1584
 Thr Thr Ser Val Ala Glu Asn Arg Asn Leu Leu Glu Asn Ala Asp Lys
         515                 520                 525

 att gaa agc acc tca gca aga gca gat tca gtt ctc aat att cca gca     1632
 Ile Glu Ser Thr Ser Ala Arg Ala Asp Ser Val Leu Asn Ile Pro Ala
     530                 535                 540

 ccc ctc cac cca gag aca act gtg aac atg acc tac cag cct aca aca     1680
 Pro Leu His Pro Glu Thr Thr Val Asn Met Thr Tyr Gln Pro Thr Thr
 545                 550                 555                 560

 ccc agt agc agt ttt cag gat gtt agc gtg ttc ggt atg gat gcg ggg     1728
 Pro Ser Ser Ser Phe Gln Asp Val Ser Val Phe Gly Met Asp Ala Gly
                 565                 570                 575

 tcc ccc ttg gta gtt cca ccc cct act gat agt gca cgc ttg ttg aac     1776
 Ser Pro Leu Val Val Pro Pro Pro Thr Asp Ser Ala Arg Leu Leu Asn
             580                 585                 590

 acg tcc ccc aaa gtg cct gac aag aac act tgc ccc agt ggg atc ccc     1824
 Thr Ser Pro Lys Val Pro Asp Lys Asn Thr Cys Pro Ser Gly Ile Pro
         595                 600                 605

 aag cct gtc ttc aca cat tcc aag gac aca cct tcc tcg cag gag gga     1872
 Lys Pro Val Phe Thr His Ser Lys Asp Thr Pro Ser Ser Gln Glu Gly
     610                 615                 620

 atg gag aac tat cag gtt gaa aaa aca gag gag agg aca gaa act aag     1920
 Met Glu Asn Tyr Gln Val Glu Lys Thr Glu Glu Arg Thr Glu Thr Lys
 625                 630                 635                 640

 ccc atc att atg ccc aag ccc aag cat gtg agg ccc aag atc atc acc     1968
 Pro Ile Ile Met Pro Lys Pro Lys His Val Arg Pro Lys Ile Ile Thr
                 645                 650                 655

 tac atc agg agg aat ccc cag gcc ctg ggc cag gtg gac gcc tcg ctg     2016
 Tyr Ile Arg Arg Asn Pro Gln Ala Leu Gly Gln Val Asp Ala Ser Leu
             660                 665                 670

 gtt cca gtg ggg ctt cca tat gcc ccg ccc aca tgt acc atg cct ctt     2064
 Val Pro Val Gly Leu Pro Tyr Ala Pro Pro Thr Cys Thr Met Pro Leu
         675                 680                 685

 ccc cac gaa gag aag gca gca ggt ggt gac ctg aag cca tct gcc aac     2112
 Pro His Glu Glu Lys Ala Ala Gly Gly Asp Leu Lys Pro Ser Ala Asn
     690                 695                 700

 ctc tat gag aaa ttc aag cca gac ctg cag aag cca agg gtc ttc agt     2160
 Leu Tyr Glu Lys Phe Lys Pro Asp Leu Gln Lys Pro Arg Val Phe Ser
 705                 710                 715                 720

 tcc gga ttg atg gtg tct gga atc aag ccc ccg gga cat cct ttc agt     2208
 Ser Gly Leu Met Val Ser Gly Ile Lys Pro Pro Gly His Pro Phe Ser
                 725                 730                 735

 caa atg agt gaa aag ttt ttg cag gag gtt aca gac cac cct gga aaa     2256
 Gln Met Ser Glu Lys Phe Leu Gln Glu Val Thr Asp His Pro Gly Lys
             740                 745                 750

 gaa gag ttt tgt tct cct ccc tat gct cat tat gaa gtc cct cca act     2304
 Glu Glu Phe Cys Ser Pro Pro Tyr Ala His Tyr Glu Val Pro Pro Thr
         755                 760                 765

 ttc tat cgg tca gcc atg ctc ctt aag ccc cag cta gga ttg ggt gca     2352
 Phe Tyr Arg Ser Ala Met Leu Leu Lys Pro Gln Leu Gly Leu Gly Ala
     770                 775                 780

 atg tcc cgt tta cca tct gca aag agc agg att ctg att gca agt cag     2400
 Met Ser Arg Leu Pro Ser Ala Lys Ser Arg Ile Leu Ile Ala Ser Gln
 785                 790                 795                 800

 agg tct tca gcg agc gcc atc cac cca cca gga ccc ata aca aca gcc     2448
 Arg Ser Ser Ala Ser Ala Ile His Pro Pro Gly Pro Ile Thr Thr Ala
                 805                 810                 815

 acc agt ctc tac agt tcc gat cct tca gat tta aag aaa gct tcc agt     2496
 Thr Ser Leu Tyr Ser Ser Asp Pro Ser Asp Leu Lys Lys Ala Ser Ser
             820                 825                 830

 tca aat gct gca aaa tcc aat ctc ccg aaa tct ggt ctc cgt cct ccc     2544
 Ser Asn Ala Ala Lys Ser Asn Leu Pro Lys Ser Gly Leu Arg Pro Pro
         835                 840                 845

 gga tac tca cgt ctc ccg gca gcc aaa ctg gcg gca ttt ggc ttt gtc     2592
 Gly Tyr Ser Arg Leu Pro Ala Ala Lys Leu Ala Ala Phe Gly Phe Val
     850                 855                 860

 cgg agc tcc agc gtc tcc tca gtc tcc agc acc cag tcc ggg gac agt     2640
 Arg Ser Ser Ser Val Ser Ser Val Ser Ser Thr Gln Ser Gly Asp Ser
 865                 870                 875                 880

 gca cag cca gag cag ggc cgg cca gcc acc cgt tca acc ttt ggg aat     2688
 Ala Gln Pro Glu Gln Gly Arg Pro Ala Thr Arg Ser Thr Phe Gly Asn
                 885                 890                 895

 gaa gaa cag cca gtt ctg aag gca tct ctg cct tct aag gac aca ccc     2736
 Glu Glu Gln Pro Val Leu Lys Ala Ser Leu Pro Ser Lys Asp Thr Pro
             900                 905                 910

 aag ggg gcc ggc cgg gtg gcc cct cca gca tcc tcc agt gtg aca gca     2784
 Lys Gly Ala Gly Arg Val Ala Pro Pro Ala Ser Ser Ser Val Thr Ala
         915                 920                 925

 ccc cgc agg agt tta ctt cca gcg cca aaa tcc act tcc aca ccc gct     2832
 Pro Arg Arg Ser Leu Leu Pro Ala Pro Lys Ser Thr Ser Thr Pro Ala
     930                 935                 940

 gga aca aag aaa gat gct ccg aaa gat caa gat acg aat aaa cct gct     2880
 Gly Thr Lys Lys Asp Ala Pro Lys Asp Gln Asp Thr Asn Lys Pro Ala
 945                 950                 955                 960

 gtt tca tct cct aag aga gta gca gct tca acc acc aag ctt cat tca     2928
 Val Ser Ser Pro Lys Arg Val Ala Ala Ser Thr Thr Lys Leu His Ser
                 965                 970                 975

 cca gga tac cca aag cag agg act gcg gca gct cga aat ggg ttt ccg     2976
 Pro Gly Tyr Pro Lys Gln Arg Thr Ala Ala Ala Arg Asn Gly Phe Pro
             980                 985                 990

 ccc aag ccg gac ccg cag gcc cgt gag gct gag cgg cag ctg gtg ctg     3024
 Pro Lys Pro Asp Pro Gln Ala Arg Glu Ala Glu Arg Gln Leu Val Leu
         995                1000                1005

 cgg ctg aag gag cgg tgt gag cag cag acc aga cag ctg ggc gtt gcg     3072
 Arg Leu Lys Glu Arg Cys Glu Gln Gln Thr Arg Gln Leu Gly Val Ala
    1010                1015                1020

 caa ggg gag ctg aag agg gcc atc tgc ggc ttt gat gcc ctc gcc gtg     3120
 Gln Gly Glu Leu Lys Arg Ala Ile Cys Gly Phe Asp Ala Leu Ala Val
1025                1030                1035                1040

 gcc acg cag cat ttc ttt aga aag aat gaa agt gcc ctt gtg aaa gaa     3168
 Ala Thr Gln His Phe Phe Arg Lys Asn Glu Ser Ala Leu Val Lys Glu
                1045                1050                1055

 aaa gag ctg tca atc gaa ctt gca aac atc agg gat gaa gtt gcc ttc     3216
 Lys Glu Leu Ser Ile Glu Leu Ala Asn Ile Arg Asp Glu Val Ala Phe
            1060                1065                1070

 cat aca gca aag tgc gag aaa cta caa aag gag aag gag gag ctg gag     3264
 His Thr Ala Lys Cys Glu Lys Leu Gln Lys Glu Lys Glu Glu Leu Glu
        1075                1080                1085

 agg cgg ttc gag gac gag gtg aag agg ctg ggc tgg cag cag cag gcc     3312
 Arg Arg Phe Glu Asp Glu Val Lys Arg Leu Gly Trp Gln Gln Gln Ala
    1090                1095                1100

 gag ctc cag gag ctg gag gag cgg ctg cag ctg caa ttc gag gcg gaa     3360
 Glu Leu Gln Glu Leu Glu Glu Arg Leu Gln Leu Gln Phe Glu Ala Glu
1105                1110                1115                1120

 atg gcg cgc ctg cag gag gag cac ggt gac cag ctg ctg agc atc cgg     3408
 Met Ala Arg Leu Gln Glu Glu His Gly Asp Gln Leu Leu Ser Ile Arg
                1125                1130                1135

 tgt caa cac cag gag cag gtg gaa gat ctc acc gcc agc cat gat gct     3456
 Cys Gln His Gln Glu Gln Val Glu Asp Leu Thr Ala Ser His Asp Ala
            1140                1145                1150

 gct ctc cta gag atg gaa aat aac cac aca gtt gcc atc aca atc ctg     3504
 Ala Leu Leu Glu Met Glu Asn Asn His Thr Val Ala Ile Thr Ile Leu
        1155                1160                1165

 cag gat gac cac gac cac aaa gtc caa gaa ttg atg tcc act cat gag     3552
 Gln Asp Asp His Asp His Lys Val Gln Glu Leu Met Ser Thr His Glu
    1170                1175                1180

 ctt gaa aag aaa gaa ttg gaa gaa aat ttt gaa aaa ctg cgg ctg tca     3600
 Leu Glu Lys Lys Glu Leu Glu Glu Asn Phe Glu Lys Leu Arg Leu Ser
1185                1190                1195                1200

 ttg cag gac cag gtg gac acg ctg acc ttc cag agc cag tct ctg cgg     3648
 Leu Gln Asp Gln Val Asp Thr Leu Thr Phe Gln Ser Gln Ser Leu Arg
                1205                1210                1215

 gac aga gcc cgc cgc ttc gaa gag gcc ttg agg aag aac aca gag gag     3696
 Asp Arg Ala Arg Arg Phe Glu Glu Ala Leu Arg Lys Asn Thr Glu Glu
            1220                1225                1230

 cag ctg gag att gca ttg gct cct tat cag cac ttg gaa gaa gac atg     3744
 Gln Leu Glu Ile Ala Leu Ala Pro Tyr Gln His Leu Glu Glu Asp Met
        1235                1240                1245

 aag agt ctg aag cag gta tta gaa atg aag aat cag caa ata cac gag     3792
 Lys Ser Leu Lys Gln Val Leu Glu Met Lys Asn Gln Gln Ile His Glu
    1250                1255                1260

 caa gaa aag aag att ctt gag ctg gaa aag ctg gca gaa aag aac att     3840
 Gln Glu Lys Lys Ile Leu Glu Leu Glu Lys Leu Ala Glu Lys Asn Ile
1265                1270                1275                1280

 atc cta gaa gaa aag atc cag gtt ctc caa cag cag aac gaa gac ctc     3888
 Ile Leu Glu Glu Lys Ile Gln Val Leu Gln Gln Gln Asn Glu Asp Leu
                1285                1290                1295

 aaa gca agg att gac caa aac aca gtt gtc acc aga cag ctg tcg gag     3936
 Lys Ala Arg Ile Asp Gln Asn Thr Val Val Thr Arg Gln Leu Ser Glu
            1300                1305                1310

 gaa aat gct aac ctc cag gaa tat gtt gag aag gaa acc cag gag aag     3984
 Glu Asn Ala Asn Leu Gln Glu Tyr Val Glu Lys Glu Thr Gln Glu Lys
        1315                1320                1325

 aag aga ttg agc cga acc aat gaa gag ctg ctt tgg aag ctc caa act     4032
 Lys Arg Leu Ser Arg Thr Asn Glu Glu Leu Leu Trp Lys Leu Gln Thr
    1330                1335                1340

 ggg gac ccg acc agt ccg att aaa ctc tcg ccc aca tct ccc gtt tac     4080
 Gly Asp Pro Thr Ser Pro Ile Lys Leu Ser Pro Thr Ser Pro Val Tyr
1345                1350                1355                1360

 cgc ggc tcc tcc tcg ggg ccc tcc tct ccg gcc aga gtc agc aca aca     4128
 Arg Gly Ser Ser Ser Gly Pro Ser Ser Pro Ala Arg Val Ser Thr Thr
                1365                1370                1375

 ccc aga tga cgccact acacggcctg cgggagctcc ggcttctcgt cctccggtct     4184
 Pro Arg 






      <210> 340
      <211> 1293
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (488)..(805)

      <400> 340
 gtaccggccc ggaataccag ggtcgctaga tactgagaaa gcagttgcat ctgactgcgc     60

 ctacgcccct ctgtggtgtg aaagcagact acacagaaaa cttgtccctc attagagaga    120

 gagccacact tctcactgct cacaatgaga ggccaaagat tacccttgga catccagatt    180

 ttctattgtg ccagacctga cgaagagcct tttgcgaaga tcatctactg ttgaagaagc    240

 gaagcgcaag acgagcacat gcctctacta tgaatacggc gacgaatagg tgctggctgt    300

 cctacgggcc cacagcgcgc tcctggagaa tatacacatc gagcagatgg cccgacgcct    360

 tcctgcaagg gtgcaagggt atccatggag actggcctat agcacgttag agcacgggac    420

 cagcttaaag acgctctacc ggaaatcggc atcactagac agtcctgtcc tattggtcat    480

 caaagat  atg gat aat cag att ttt gga gca tat gca act cat cct ttc     529
          Met Asp Asn Gln Ile Phe Gly Ala Tyr Ala Thr His Pro Phe
            1               5                  10

 aag ttc agt gac cac tat tat ggc aca ggc gaa act ttt ctc tac aca      577
 Lys Phe Ser Asp His Tyr Tyr Gly Thr Gly Glu Thr Phe Leu Tyr Thr
  15                  20                  25                  30

 ttc agc cct cat ttt aag gtc ttt aag tgg agt gga gaa aat tca tac      625
 Phe Ser Pro His Phe Lys Val Phe Lys Trp Ser Gly Glu Asn Ser Tyr
                  35                  40                  45

 ttt atc aat gga gac ata agt tct tta gaa ctt ggt ggt gga ggg gga      673
 Phe Ile Asn Gly Asp Ile Ser Ser Leu Glu Leu Gly Gly Gly Gly Gly
              50                  55                  60

 cga ttt ggt tta tgg cta gat gct gat tta tac cac gga cga agc aac      721
 Arg Phe Gly Leu Trp Leu Asp Ala Asp Leu Tyr His Gly Arg Ser Asn
          65                  70                  75

 tct tgc agc act ttc aat aat gat att ctt tcc aaa aag gaa gac ttc      769
 Ser Cys Ser Thr Phe Asn Asn Asp Ile Leu Ser Lys Lys Glu Asp Phe
      80                  85                  90

 ata gtt cag gat ctg gag gtg tgg gca ttt gat tga aatt cagactgcct      819
 Ile Val Gln Asp Leu Glu Val Trp Ala Phe Asp 
  95                 100                 105

 taaaatataa cattaaaaag actgggttcg atcagccctc ctaaagctgg ctggaaaaag    879

 aagccccagc ccagcctgcc tcatcccacc ccaatgcttc ctttctgcca tcatctcaga    939

 gcatgatcac attgcagaaa gattctggaa ggtccatgta gagggcagac attgaagaaa    999

 gaaacttaaa atccaggttg ttgaaaagac tttgtactcc cacttcctcc aaatccatac   1059

 agtgaggaat cagagtgttt atagatatat gagttgaatg caatttttat ttttggtaac   1119

 tgaaaaataa gatactgtgg atatatacat gccttgtgta tttatcagca taattttcat   1179

 taccaaaatg tacagctatt atttgccatg gaaaaggtta gtctcattta gaaaaatcga   1239

 aagtgcacag cacttaaagg gaatatatga ggtttttttt ttaaaaaaaa aaaa         1293




      <210> 341
      <211> 1675
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (882)..(1406)

      <400> 341
 ctgcgacttt taatctttgc ccttcccttt gacctctact gtctgctctc ccctcccact     60

 agaaatacaa gaaacccaag tttatccctt gctttgtgtt ccttccggat ggagacattc    120

 tcactggaga ctcagagggg aacattctca cctgggggcg gagcccttca gattccaaga    180

 ccccaggcag gggtggcgcc aaagagacct atgggattgt ggcccaggct cacgctcatg    240

 aaggttctat cttcgccttg tgtctccgga gggacgggac agtgctgagt ggtggcgggc    300

 gggaccgccg gctggtacag tgggggcccg ggttggtggc cctccaggag gctgagattc    360

 ccgagcactt cggggccgtg cgagccattg ctgaagggct tggctctgag ctgctggtgg    420

 gaaccacgaa gaatgcattg ctgaggggag acctggccca gggcttctcc cctgtaatcc    480

 agggccacac tgatgagctc tgggggctct gcacacaccc ctcccagaac cgcttcctca    540

 cctgcggcca cgaccggcag ctctgcctgt gggatgggga gagccatgca ctggcctgga    600

 gcatcgacct caaggagact ggtctctgtg ctgacttcca cccgagtggg gcagttgtgg    660

 ccgtaggact gaacacgggg aggtggttgg ttttggacac agagaccaga gagatcgtgt    720

 ctgatgtcat tgatggcaat gagcagctct cagtggtccg gtacagccca gtgactgtat    780

 ttgcagatgg gttgtacctg gccattggtt cccatgacaa cgtgatctac atctatagtg    840

 tttccagtga tggtgccaaa tccagccgct ttggccgctg t    atg ggt cac tcc     893
                                                  Met Gly His Ser
                                                    1

 agc ttc atc act cat ctt gac tgg tcc aag gat ggg aat ttc atc atg      941
 Ser Phe Ile Thr His Leu Asp Trp Ser Lys Asp Gly Asn Phe Ile Met
   5                  10                  15                  20

 tcc aat tct ggg gac tat gag att ctt tac tgg gac gtg gct gga ggc      989
 Ser Asn Ser Gly Asp Tyr Glu Ile Leu Tyr Trp Asp Val Ala Gly Gly
                  25                  30                  35

 tgc aag cag ctg aag aat cgc tat gag agc cga gac cgg gaa tgg gct     1037
 Cys Lys Gln Leu Lys Asn Arg Tyr Glu Ser Arg Asp Arg Glu Trp Ala
              40                  45                  50

 acc tac acc tgt gtg ctg ggc ttt cac gtc tac ggc gtc tgg ccg gac     1085
 Thr Tyr Thr Cys Val Leu Gly Phe His Val Tyr Gly Val Trp Pro Asp
          55                  60                  65

 ggc tcc gat ggg acc gac atc aac tcc ctg tgc cgc tcc cac aac gag     1133
 Gly Ser Asp Gly Thr Asp Ile Asn Ser Leu Cys Arg Ser His Asn Glu
      70                  75                  80

 cgc gtg gtg gcg gtg gcc gac gac ttc tgc aaa gtg cat ctc ttc cag     1181
 Arg Val Val Ala Val Ala Asp Asp Phe Cys Lys Val His Leu Phe Gln
  85                  90                  95                 100

 tac ccg tgc gct cgt gcc aag gcg ccg agc cgc atg tac ggg ggc cac     1229
 Tyr Pro Cys Ala Arg Ala Lys Ala Pro Ser Arg Met Tyr Gly Gly His
                 105                 110                 115

 ggc agc cac gtg acc agc gtc cga ttc acg cac gac gac tcg cac ctc     1277
 Gly Ser His Val Thr Ser Val Arg Phe Thr His Asp Asp Ser His Leu
             120                 125                 130

 gtc tcg ctg ggc ggc aag gac gcc agc atc ttc cag tgg cga gtg ctg     1325
 Val Ser Leu Gly Gly Lys Asp Ala Ser Ile Phe Gln Trp Arg Val Leu
         135                 140                 145

 ggc gct ggg ggc gcg ggg ccg gcg ccc gcc acg ccc tct cga acc ccc     1373
 Gly Ala Gly Gly Ala Gly Pro Ala Pro Ala Thr Pro Ser Arg Thr Pro
     150                 155                 160

 tcc ctg tcc ccc gcc tcc tcc ctc gac gtt tga tcgctgcc tggcgggacc     1424
 Ser Leu Ser Pro Ala Ser Ser Leu Asp Val 
 165                 170

 gactggcccg gcggcgtggc cccgccccgc cctgcccttc cctgccctaa tcccccacga   1484

 ctaggggccg actctttcct ggactgactt cgagacattc ccgatcgcgc attttcctgg   1544

 agggcgcgaa cggcgcccct gcacacactg tttagacccg ctggctgagc cgggcagccc   1604

 cagcctaggc cttgactccc gctgcctgct gaggggcaat aaaccagaac caaagtcgca   1664

 aaaaaaaaaa a                                                        1675




      <210> 342
      <211> 2083
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (872)..(1909)

      <400> 342
 aaacaacaaa aaaaaaagcc cacgttcaat ggcagcacta ttcaaaagat ggaagcaact     60

 caagtatcca aacgcgcatg agtgaacaca tcgtggttca tccacagtgg aacacgattc    120

 agccagaaaa aggaaggaaa ccggcctgca ccgtgacttg gatgcacctg gaggagactg    180

 tgatgaacga aagcagccag acgcaaaagg gcaaggacgg cctacgcggc tgtaggctgg    240

 accctggctt ggcctcaccc ttgggacatg aagggctggc cggggtgagg ctagaccatg    300

 agggctctga caagaggacc aagcaccggg gccccgagcc tgccccgctg gagactgagg    360

 ccacctctgc ccgcaggtct ctgaaggtcg gcctgcagat ctccctggac tactggtggt    420

 gcaccaatgt tgtccttcga ggggtggaag agaacagccc aggctacttg gaggtgatgt    480

 ctgcgtctgc aagcgggcgg ctgatgccct ggtggcaggg gccatcagca acgggggcct    540

 ctacgtgaag ctgggccagg ggctgtgctc cttcaaccac ctgcttcccc ccgagtatac    600

 ccggaccctg cgcgtgctag aggacagggc cctcaagcgg ggcttccagg aggtggatga    660

 gttgttcctt gaggacttcc aggccctccc ccacgagctc ttccaggagt ttgactacca    720

 gccaattgct gccgccagcc tggcacaggt gcacagagcc aagctgcacg atggcaccag    780

 cgtggctgtg aaggtgcagt acatcgacct gcgggaccgc tttgatgggg acatccacac    840

 cctggagctc ctgctgcggc tcgttgaggt c   atg cac ccc agc ttt ggc ttc     892
                                      Met His Pro Ser Phe Gly Phe
                                        1               5

 agc tgg gtc ctc cag gac ctg aag ggg acc ctg gcc cag gag ctg gac      940
 Ser Trp Val Leu Gln Asp Leu Lys Gly Thr Leu Ala Gln Glu Leu Asp
          10                  15                  20

 ttc gag aat gag ggc cgc aac gca gag cgc tgt gcg cgg gag ctg gcg      988
 Phe Glu Asn Glu Gly Arg Asn Ala Glu Arg Cys Ala Arg Glu Leu Ala
      25                  30                  35

 cac ttc ccc tac gtc gtg gtg ccc cgc gtg cac tgg gac aag tcc agc     1036
 His Phe Pro Tyr Val Val Val Pro Arg Val His Trp Asp Lys Ser Ser
  40                  45                  50                  55

 aag cgc gtg ctc act gcc gac ttc tgc gcc ggc tgc aag gtc aac gat     1084
 Lys Arg Val Leu Thr Ala Asp Phe Cys Ala Gly Cys Lys Val Asn Asp
                  60                  65                  70

 gtg gag gcc atc agg agc cag ggg ctg gca gtg cat tac ttg agt gcg     1132
 Val Glu Ala Ile Arg Ser Gln Gly Leu Ala Val His Tyr Leu Ser Ala
              75                  80                  85

 ggg ggg cgg ggg cgg ata gca aaa aag ctc atc aag gcc ttt gct gag     1180
 Gly Gly Arg Gly Arg Ile Ala Lys Lys Leu Ile Lys Ala Phe Ala Glu
          90                  95                 100

 cag ata ttt tac acc ggc ttc atc cac tcg gac cca cat cct ggc aac     1228
 Gln Ile Phe Tyr Thr Gly Phe Ile His Ser Asp Pro His Pro Gly Asn
     105                 110                 115

 gtt ctg gtg cgg aaa ggc ccg gac ggg aaa gcg gag ctg gtg ctg ctg     1276
 Val Leu Val Arg Lys Gly Pro Asp Gly Lys Ala Glu Leu Val Leu Leu
 120                 125                 130                 135

 gac cac ggg ctc tac cag ttc ctg gag gaa aag gag ctc atg gct gcg     1324
 Asp His Gly Leu Tyr Gln Phe Leu Glu Glu Lys Glu Leu Met Ala Ala
                 140                 145                 150

 ggc cca tcc aca ccc agg gac cgc gca gcc ctc tgc cag ctg tgg cgg     1372
 Gly Pro Ser Thr Pro Arg Asp Arg Ala Ala Leu Cys Gln Leu Trp Arg
             155                 160                 165

 gcc atc atc ctg cgg gac gac gcc gcc atg agg gcg cac gca gcc gca     1420
 Ala Ile Ile Leu Arg Asp Asp Ala Ala Met Arg Ala His Ala Ala Ala
         170                 175                 180

 ctg ggg gtg caa gat tac ctc ctg ttc gcc gag atg ctc atg cag cgc     1468
 Leu Gly Val Gln Asp Tyr Leu Leu Phe Ala Glu Met Leu Met Gln Arg
     185                 190                 195

 ccc gtg cgc ctg ggg cag ctg tgg ggc tcg cac cta ctg agc cgc gaa     1516
 Pro Val Arg Leu Gly Gln Leu Trp Gly Ser His Leu Leu Ser Arg Glu
 200                 205                 210                 215

 gag gcg gcc tac atg gtg gac atg gcc cgc gag cgc ttc gag gcc gtc     1564
 Glu Ala Ala Tyr Met Val Asp Met Ala Arg Glu Arg Phe Glu Ala Val
                 220                 225                 230

 atg gcg gtg ctc agg gag ctg ccg cgg ccc atg ctg gtg gtg ctg cgc     1612
 Met Ala Val Leu Arg Glu Leu Pro Arg Pro Met Leu Val Val Leu Arg
             235                 240                 245

 aac atc aac acc gtg cgc gct atc aac gtg gcc ctc ggc gcc ccc gtg     1660
 Asn Ile Asn Thr Val Arg Ala Ile Asn Val Ala Leu Gly Ala Pro Val
         250                 255                 260

 gac cgc tac ttc ctt atg gct aaa agg gtt gtc cgg ggc tgg agc cgc     1708
 Asp Arg Tyr Phe Leu Met Ala Lys Arg Val Val Arg Gly Trp Ser Arg
     265                 270                 275

 ctg gcg ggc gcc acg tat cgg ggt gtt tac ggc act agc ctc ctg cgc     1756
 Leu Ala Gly Ala Thr Tyr Arg Gly Val Tyr Gly Thr Ser Leu Leu Arg
 280                 285                 290                 295

 cac gcc aag gtc gtc tgg gag atg ctc aag ttt gaa gtg gcg ctc agg     1804
 His Ala Lys Val Val Trp Glu Met Leu Lys Phe Glu Val Ala Leu Arg
                 300                 305                 310

 ctg gag acc ttg gcc atg cgg ctg acc gcc ctc ctg gct cgt gct ttg     1852
 Leu Glu Thr Leu Ala Met Arg Leu Thr Ala Leu Leu Ala Arg Ala Leu
             315                 320                 325

 gtc cac ctg agc ctc gtg ccc cca gcg gag gag ctc tac cag tac ctg     1900
 Val His Leu Ser Leu Val Pro Pro Ala Glu Glu Leu Tyr Gln Tyr Leu
         330                 335                 340

 gag acc tag ggtgcaa cccgcccagg gccggcgggg cccttttcac cttgggctga     1956
 Glu Thr 
     345

 cggaggtggc ggggctaaag gtgtagacac ccccgagccc cgtgggcact cgcactgggg   2016

 ggctgtgaca gcagctgggc caggaggccg tgtaatgacc acacactcct ttcaagcaaa   2076

 aaaaaaa                                                             2083




      <210> 343
      <211> 2572
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(2282)

      <400> 343
 ccaacaccgc ctttctcagc    atg gag acc ttt gag ccc atc agc caa gag      50
                          Met Glu Thr Phe Glu Pro Ile Ser Gln Glu
                            1               5                  10

 ccc ctc agc caa gcc agc tat gac aaa gcc cca gac cca gtt cct gag       98
 Pro Leu Ser Gln Ala Ser Tyr Asp Lys Ala Pro Asp Pro Val Pro Glu
                  15                  20                  25

 ctc caa gac tcg ttc tat gca gaa ctg caa cgt gca gag agc ctc caa      146
 Leu Gln Asp Ser Phe Tyr Ala Glu Leu Gln Arg Ala Glu Ser Leu Gln
              30                  35                  40

 gag aag agc ata aaa gag gcc aag acc aaa tgc agg aca att gca tcc      194
 Glu Lys Ser Ile Lys Glu Ala Lys Thr Lys Cys Arg Thr Ile Ala Ser
          45                  50                  55

 ctg ctc act gca gcc ccc aac ccc cac tcc aaa ggg gta ctt atg ttt      242
 Leu Leu Thr Ala Ala Pro Asn Pro His Ser Lys Gly Val Leu Met Phe
      60                  65                  70

 aag aaa cgg cgg cag aga gcc aag aag tac acc ctg gtg agc ttc ggg      290
 Lys Lys Arg Arg Gln Arg Ala Lys Lys Tyr Thr Leu Val Ser Phe Gly
  75                  80                  85                  90

 gct gct gct ggg aca ggc gct gag gag gag gac ggc gtt ccc ccc acg      338
 Ala Ala Ala Gly Thr Gly Ala Glu Glu Glu Asp Gly Val Pro Pro Thr
                  95                 100                 105

 agt gag tcc gag ctg gac gaa gaa gcc ttc tct gac gcc cgc agc ctc      386
 Ser Glu Ser Glu Leu Asp Glu Glu Ala Phe Ser Asp Ala Arg Ser Leu
             110                 115                 120

 acc aat caa tct gac tgg gac agt ccc tat ctg gac atg gag ctt gcc      434
 Thr Asn Gln Ser Asp Trp Asp Ser Pro Tyr Leu Asp Met Glu Leu Ala
         125                 130                 135

 agg gcg ggc tca aga gca tca gag ggc cag ggc tct ggg ctg gga ggg      482
 Arg Ala Gly Ser Arg Ala Ser Glu Gly Gln Gly Ser Gly Leu Gly Gly
     140                 145                 150

 cag ctg agt gag gtc tct ggg cga ggg gtg cag ctc ttt gaa cag cag      530
 Gln Leu Ser Glu Val Ser Gly Arg Gly Val Gln Leu Phe Glu Gln Gln
 155                 160                 165                 170

 cgc cag cgc gca gac tcc agc acc cag gaa ctg gca cgg gtc gaa cca      578
 Arg Gln Arg Ala Asp Ser Ser Thr Gln Glu Leu Ala Arg Val Glu Pro
                 175                 180                 185

 gca gcc atg ctc aac ggg gaa ggc ctg cag tca cca cct cgg gcc cag      626
 Ala Ala Met Leu Asn Gly Glu Gly Leu Gln Ser Pro Pro Arg Ala Gln
             190                 195                 200

 agt gct ccc cca gag gca gct gtg ctc cca ccc agc ccc ttg ccg gcg      674
 Ser Ala Pro Pro Glu Ala Ala Val Leu Pro Pro Ser Pro Leu Pro Ala
         205                 210                 215

 cct gta gcc agc ccc aga ccc ttc caa cca ggt ggt gga gcc ccg acc      722
 Pro Val Ala Ser Pro Arg Pro Phe Gln Pro Gly Gly Gly Ala Pro Thr
     220                 225                 230

 cca gct cca agc atc ttt aac cgg tca gcc agg ccc ttt acc ccg ggc      770
 Pro Ala Pro Ser Ile Phe Asn Arg Ser Ala Arg Pro Phe Thr Pro Gly
 235                 240                 245                 250

 cta caa ggg cag cgg cca act acc acc tcg gtt att ttc cgg cct tta      818
 Leu Gln Gly Gln Arg Pro Thr Thr Thr Ser Val Ile Phe Arg Pro Leu
                 255                 260                 265

 gcc ccc aaa agg gcg aac gac agc ctg ggg ggc ctc agc ccc gcc cca      866
 Ala Pro Lys Arg Ala Asn Asp Ser Leu Gly Gly Leu Ser Pro Ala Pro
             270                 275                 280

 ccc ccc ttc ttg tct tcg cag ggg ccc acc cct ctg ccc agc ttc act      914
 Pro Pro Phe Leu Ser Ser Gln Gly Pro Thr Pro Leu Pro Ser Phe Thr
         285                 290                 295

 tca ggg gtt ccc agc cac gcg cca gtc tct ggt tcc ccc agc acc cca      962
 Ser Gly Val Pro Ser His Ala Pro Val Ser Gly Ser Pro Ser Thr Pro
     300                 305                 310

 cgc tcc tcg ggc cct gtg aca gcc acc agc tcc ctg tac atc cca gcc     1010
 Arg Ser Ser Gly Pro Val Thr Ala Thr Ser Ser Leu Tyr Ile Pro Ala
 315                 320                 325                 330

 cct agt cgg cct gtc acc cca ggt gga gct cca gag ccc ccc gct cct     1058
 Pro Ser Arg Pro Val Thr Pro Gly Gly Ala Pro Glu Pro Pro Ala Pro
                 335                 340                 345

 cct agc gca gct gcc atg acc tcc acc gct tct atc ttc cta tct gcg     1106
 Pro Ser Ala Ala Ala Met Thr Ser Thr Ala Ser Ile Phe Leu Ser Ala
             350                 355                 360

 cct ttg cga ccc tct gcg cgc cca gag gcg cct gcc cca ggc cca ggg     1154
 Pro Leu Arg Pro Ser Ala Arg Pro Glu Ala Pro Ala Pro Gly Pro Gly
         365                 370                 375

 gct cct gag ccc ccc agc gct cgc gag cag cgc atc tct gtg cca gct     1202
 Ala Pro Glu Pro Pro Ser Ala Arg Glu Gln Arg Ile Ser Val Pro Ala
     380                 385                 390

 gcc cgc acg ggt atc ctg cag gag gcc cgg cgc cgg ggg acc cgg aag     1250
 Ala Arg Thr Gly Ile Leu Gln Glu Ala Arg Arg Arg Gly Thr Arg Lys
 395                 400                 405                 410

 cag atg ttc cgg ccg gga aag gag gag acg aag aac tcg ccc aac ccc     1298
 Gln Met Phe Arg Pro Gly Lys Glu Glu Thr Lys Asn Ser Pro Asn Pro
                 415                 420                 425

 gag ctg cta tcg ctg gta cag aac ctg gat gaa aag cct cgg gcc ggg     1346
 Glu Leu Leu Ser Leu Val Gln Asn Leu Asp Glu Lys Pro Arg Ala Gly
             430                 435                 440

 ggt gca gaa tct ggt cct gaa gaa gat gct ctg agc ctc ggg gct gaa     1394
 Gly Ala Glu Ser Gly Pro Glu Glu Asp Ala Leu Ser Leu Gly Ala Glu
         445                 450                 455

 gcc tgc aac ttc atg cag cca gta ggg gcc agg agt tac aag acc ctg     1442
 Ala Cys Asn Phe Met Gln Pro Val Gly Ala Arg Ser Tyr Lys Thr Leu
     460                 465                 470

 cct cac gtg aca cct aag acc ccc cct cca atg gct ccc aag acc ccg     1490
 Pro His Val Thr Pro Lys Thr Pro Pro Pro Met Ala Pro Lys Thr Pro
 475                 480                 485                 490

 ccc cct atg act cct aag act cca ccc cca gtg gct cct aag ccc cca     1538
 Pro Pro Met Thr Pro Lys Thr Pro Pro Pro Val Ala Pro Lys Pro Pro
                 495                 500                 505

 tct cga ggg ctc ctt gat ggg ctc gtg aat ggg gca gcc tct tcg gct     1586
 Ser Arg Gly Leu Leu Asp Gly Leu Val Asn Gly Ala Ala Ser Ser Ala
             510                 515                 520

 gga atc cct gag cca cca agg ctg cag ggc agg ggt ggg gag ctg ttt     1634
 Gly Ile Pro Glu Pro Pro Arg Leu Gln Gly Arg Gly Gly Glu Leu Phe
         525                 530                 535

 gct aag cgg cag agc cgt gcg gac agg tat gtg gtg gaa ggt aca cct     1682
 Ala Lys Arg Gln Ser Arg Ala Asp Arg Tyr Val Val Glu Gly Thr Pro
     540                 545                 550

 ggt cct ggt ctt ggc cct cgg cct aga agt cct tct cct acc ccg tct     1730
 Gly Pro Gly Leu Gly Pro Arg Pro Arg Ser Pro Ser Pro Thr Pro Ser
 555                 560                 565                 570

 ctg ccc cct tcc tgg aaa tat tca ccc aac atc cgt gcc ccg cct cct     1778
 Leu Pro Pro Ser Trp Lys Tyr Ser Pro Asn Ile Arg Ala Pro Pro Pro
                 575                 580                 585

 att gct tac aac cca ctg ctc tct ccc ttt ttc ccc cag gcg gcc cga     1826
 Ile Ala Tyr Asn Pro Leu Leu Ser Pro Phe Phe Pro Gln Ala Ala Arg
             590                 595                 600

 act ctc cct aag gcc caa tac cag ggg cct cgg gca aca ccc aag cag     1874
 Thr Leu Pro Lys Ala Gln Tyr Gln Gly Pro Arg Ala Thr Pro Lys Gln
         605                 610                 615

 ggc atc aag gct cta gat ttt atg cgg cat cag ccc tat caa ctt aaa     1922
 Gly Ile Lys Ala Leu Asp Phe Met Arg His Gln Pro Tyr Gln Leu Lys
     620                 625                 630

 act gcc atg ttc tgt ttt gat gag gtt ccc ccg act cct ggc cct atc     1970
 Thr Ala Met Phe Cys Phe Asp Glu Val Pro Pro Thr Pro Gly Pro Ile
 635                 640                 645                 650

 gcc tca ggg tcc ccc aaa act gcc cga gtc cag gag att cgc cgg ttt     2018
 Ala Ser Gly Ser Pro Lys Thr Ala Arg Val Gln Glu Ile Arg Arg Phe
                 655                 660                 665

 tcc act ccg gca ccc cag ccc act gca gaa ccc ctg gct ccc act gtg     2066
 Ser Thr Pro Ala Pro Gln Pro Thr Ala Glu Pro Leu Ala Pro Thr Val
             670                 675                 680

 ctt gcc ccc cga gca gcc act aca ctg gat gag ccc atc tgg aga aca     2114
 Leu Ala Pro Arg Ala Ala Thr Thr Leu Asp Glu Pro Ile Trp Arg Thr
         685                 690                 695

 gaa ctg gcc tca gcc cct gtt cct agc cca gcc cct cct cca gag gct     2162
 Glu Leu Ala Ser Ala Pro Val Pro Ser Pro Ala Pro Pro Pro Glu Ala
     700                 705                 710

 ccc agg ggc ctt ggg gct tct ccc agc tcc tgc ggt ttc cag gta gcc     2210
 Pro Arg Gly Leu Gly Ala Ser Pro Ser Ser Cys Gly Phe Gln Val Ala
 715                 720                 725                 730

 agg ccc cga ttt tca gcc acc aga aca gga ttg caa gct cat gtg tgg     2258
 Arg Pro Arg Phe Ser Ala Thr Arg Thr Gly Leu Gln Ala His Val Trp
                 735                 740                 745

 agg cct ggg gca ggg cac cag tga acaggcacag gtcccaggac caaggagagg    2312
 Arg Pro Gly Ala Gly His Gln 
             750

 tggaacatcc agttcctaaa gttgcttctc ctaccctatc ccatcccctg tcacgcatct   2372

 ggaagctaaa ttgcctcctg ccagagatgg tttccaagtt gatgtcccct tcccccacct   2432

 tcctcctcac tctctacctc cctgccgctt tccaaccaag tatgtctgct ttggtatctt   2492

 tgcctctttt tgtctctgca tttcctttcc tggatctctg tctttatttc caggcttctc   2552

 cacccatatt cctccacaga                                               2572




      <210> 344
      <211> 513
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(446)

      <400> 344
 agagcacgtc aggcggcgcc    atg ctc agc gcc cag gag cgc gcc caa atc      50
                          Met Leu Ser Ala Gln Glu Arg Ala Gln Ile
                            1               5                  10

 gcg cag gtc tgg gac ctg att gcg ggc cac gag gcg caa ttc ggg gcg       98
 Ala Gln Val Trp Asp Leu Ile Ala Gly His Glu Ala Gln Phe Gly Ala
                  15                  20                  25

 gag ctg ctg ctc agg ctc ttc acg gtg tac ccc agc acc aag gtc tac      146
 Glu Leu Leu Leu Arg Leu Phe Thr Val Tyr Pro Ser Thr Lys Val Tyr
              30                  35                  40

 ttc ccg cac ctg agc gcc tgc cag gac gcg acg cag ctg ctg agc cac      194
 Phe Pro His Leu Ser Ala Cys Gln Asp Ala Thr Gln Leu Leu Ser His
          45                  50                  55

 ggg cag cgc atg ctg gcg gct gtg ggc gcg gcg gtg cag cac gtg gac      242
 Gly Gln Arg Met Leu Ala Ala Val Gly Ala Ala Val Gln His Val Asp
      60                  65                  70

 aac ctg cgc gcc gcg ctg agc ccg ctg gcg gac ctg cac gcg ctc gtg      290
 Asn Leu Arg Ala Ala Leu Ser Pro Leu Ala Asp Leu His Ala Leu Val
  75                  80                  85                  90

 ctg cgc gtg gac cca gcc aac ttt ccg ctg cta atc cag tgt ttc cac      338
 Leu Arg Val Asp Pro Ala Asn Phe Pro Leu Leu Ile Gln Cys Phe His
                  95                 100                 105

 gtc gtg ctg gcc tcc cac ctg cag gac gag ttc acc gtg caa atg caa      386
 Val Val Leu Ala Ser His Leu Gln Asp Glu Phe Thr Val Gln Met Gln
             110                 115                 120

 gcg gcg tgg gac aag ttc ctg act ggt gtg gcc gtg gtg ctg acc gaa      434
 Ala Ala Trp Asp Lys Phe Leu Thr Gly Val Ala Val Val Leu Thr Glu
         125                 130                 135

 aaa tac cgc tga gcc ctgtgctgcg caggccttgg tctgtgcctg tcaataaaca      489
 Lys Tyr Arg 
     140

 gaggcccgaa ccaaaaaaaa aaaa                                           513




      <210> 345
      <211> 627
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (21)..(560)

      <400> 345
 agagcacgtc aggcggcgcc    atg ctc agc gcc cag gag cgc gcc caa atc      50
                          Met Leu Ser Ala Gln Glu Arg Ala Gln Ile
                            1               5                  10

 gcg cag gtc tgg gac ctg att gcg ggc cac gag gcg caa ttc ggg gcg       98
 Ala Gln Val Trp Asp Leu Ile Ala Gly His Glu Ala Gln Phe Gly Ala
                  15                  20                  25

 gag ctg ctg ctc agg tcg gta gag gcg ggg tct ccg gga gct cag gag      146
 Glu Leu Leu Leu Arg Ser Val Glu Ala Gly Ser Pro Gly Ala Gln Glu
              30                  35                  40

 gtg gag atg agg gtt ttg ggc gcg tgg gcc gcc aac gcc atc caa ggt      194
 Val Glu Met Arg Val Leu Gly Ala Trp Ala Ala Asn Ala Ile Gln Gly
          45                  50                  55

 cct tcg ggt gcg gat ccc cgg ggc tct ggg cgg ctc ttc acg gtg tac      242
 Pro Ser Gly Ala Asp Pro Arg Gly Ser Gly Arg Leu Phe Thr Val Tyr
      60                  65                  70

 ccc agc acc aag gtc tac ttc ccg cac ctg agc gcc tgc cag gac gcg      290
 Pro Ser Thr Lys Val Tyr Phe Pro His Leu Ser Ala Cys Gln Asp Ala
  75                  80                  85                  90

 acg cag ctg ctg agc cac ggg cag cgc atg ctg gcg gct gtg ggc gcg      338
 Thr Gln Leu Leu Ser His Gly Gln Arg Met Leu Ala Ala Val Gly Ala
                  95                 100                 105

 gcg gtg cag cac gtg gac aac ctg cgc gcc gcg ctg agc ccg ctg gcg      386
 Ala Val Gln His Val Asp Asn Leu Arg Ala Ala Leu Ser Pro Leu Ala
             110                 115                 120

 gac ctg cac gcg ctc gtg ctg cgc gtg gac cca gcc aac ttt ccg ctg      434
 Asp Leu His Ala Leu Val Leu Arg Val Asp Pro Ala Asn Phe Pro Leu
         125                 130                 135

 cta atc cag tgt ttc cac gtc gtg ctg gcc tcc cac ctg cag gac gag      482
 Leu Ile Gln Cys Phe His Val Val Leu Ala Ser His Leu Gln Asp Glu
     140                 145                 150

 ttc acc gtg caa atg caa gcg gcg tgg gac aag ttc ctg act ggt gtg      530
 Phe Thr Val Gln Met Gln Ala Ala Trp Asp Lys Phe Leu Thr Gly Val
 155                 160                 165                 170

 gcc gtg gtg ctg acc gaa aaa tac cgc tga g ccctgtgctg cgcaggcctt      581
 Ala Val Val Leu Thr Glu Lys Tyr Arg 
                 175

 ggtctgtgcc tgtcaataaa cagaggcccg aaccaaaaaa aaaaaa                   627




      <210> 346
      <211> 1648
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (173)..(1177)

      <400> 346
 cgtagccgga gcgcctgggg aaggcggaga tgaagaccac gccgccgcgc gccgggagct     60

 gctgagccta ccgccgccag agtccagttg acacttactt tgacaaaggc aaatttggaa    120

 gcaattactt gaggacagtt catatagcat ctggacagtc aacacgggca cc    atg     175
                                                              Met
                                                                1

 aag cac ttc ctg aga atg ttg atc cag gta tgc ctg tat ttt tac tgt      223
 Lys His Phe Leu Arg Met Leu Ile Gln Val Cys Leu Tyr Phe Tyr Cys
               5                  10                  15

 aaa ttt ctg tgg cgc tgc ctg aaa ttt gta atg agg aag cta act gga      271
 Lys Phe Leu Trp Arg Cys Leu Lys Phe Val Met Arg Lys Leu Thr Gly
          20                  25                  30

 aga tgt gaa cta caa cgg atc tgt tat aat acc aag ccg gga gct tct      319
 Arg Cys Glu Leu Gln Arg Ile Cys Tyr Asn Thr Lys Pro Gly Ala Ser
      35                  40                  45

 aga acc atg aaa atc gaa aca tca ctg agg gat tct aaa agt aag ctg      367
 Arg Thr Met Lys Ile Glu Thr Ser Leu Arg Asp Ser Lys Ser Lys Leu
  50                  55                  60                  65

 ctg cag act tct gtg agt gtt cac ccc gac gct att gaa aaa act ata      415
 Leu Gln Thr Ser Val Ser Val His Pro Asp Ala Ile Glu Lys Thr Ile
                  70                  75                  80

 gaa gat atc atg gaa ctg aaa aaa att aat cct gac gta aat cca cag      463
 Glu Asp Ile Met Glu Leu Lys Lys Ile Asn Pro Asp Val Asn Pro Gln
              85                  90                  95

 ctg gga atc tct ctt cag gct tgc ctt ctg caa atc gtt ggg tac agg      511
 Leu Gly Ile Ser Leu Gln Ala Cys Leu Leu Gln Ile Val Gly Tyr Arg
         100                 105                 110

 aac ctt att gca gat gtg gaa aaa ctg cgt aga gag gcc tat gat tct      559
 Asn Leu Ile Ala Asp Val Glu Lys Leu Arg Arg Glu Ala Tyr Asp Ser
     115                 120                 125

 gat aat ccc caa cat gaa gaa atg ctt ttg aaa tta tgg aaa ttc ttg      607
 Asp Asn Pro Gln His Glu Glu Met Leu Leu Lys Leu Trp Lys Phe Leu
 130                 135                 140                 145

 aag ccc aat act cca ctg gaa tct cgg att tct aag cag tgg tgt gaa      655
 Lys Pro Asn Thr Pro Leu Glu Ser Arg Ile Ser Lys Gln Trp Cys Glu
                 150                 155                 160

 att ggt ttc caa ggt gat gat cct aaa aca gac ttt cga gga atg gga      703
 Ile Gly Phe Gln Gly Asp Asp Pro Lys Thr Asp Phe Arg Gly Met Gly
             165                 170                 175

 ctt ctg gga ctg tac aat ttg cag tat ttc gcg gaa agg gat gcc aca      751
 Leu Leu Gly Leu Tyr Asn Leu Gln Tyr Phe Ala Glu Arg Asp Ala Thr
         180                 185                 190

 gca gct cag cag gtc ctg tct gac tct ctt cat ccg aaa tgc agg gat      799
 Ala Ala Gln Gln Val Leu Ser Asp Ser Leu His Pro Lys Cys Arg Asp
     195                 200                 205

 atc act aaa gaa gaa ata agc aaa ttc agc aaa gca gaa tgg gag aag      847
 Ile Thr Lys Glu Glu Ile Ser Lys Phe Ser Lys Ala Glu Trp Glu Lys
 210                 215                 220                 225

 aaa agg atg gat aag gca att ggg tac tca ttt gca att gtg ggc atc      895
 Lys Arg Met Asp Lys Ala Ile Gly Tyr Ser Phe Ala Ile Val Gly Ile
                 230                 235                 240

 aat ata act gac ctg gca tat aat cta ctg gtc agc gga gct cta aaa      943
 Asn Ile Thr Asp Leu Ala Tyr Asn Leu Leu Val Ser Gly Ala Leu Lys
             245                 250                 255

 acc cat ttc tac aat atc gcc cca gaa gct cca aca ttg tct cac ttt      991
 Thr His Phe Tyr Asn Ile Ala Pro Glu Ala Pro Thr Leu Ser His Phe
         260                 265                 270

 cag caa aca ttc tgc tat ttg atg cat gaa ttt cat aag ttt tgg atc     1039
 Gln Gln Thr Phe Cys Tyr Leu Met His Glu Phe His Lys Phe Trp Ile
     275                 280                 285

 gaa gag gac ccc atg gac ata atg gaa ttt aat cgt gtg agg gag aaa     1087
 Glu Glu Asp Pro Met Asp Ile Met Glu Phe Asn Arg Val Arg Glu Lys
 290                 295                 300                 305

 ttc cgc aag agg atc atc aaa cag ctg cag aac cca gac atg gcg ctg     1135
 Phe Arg Lys Arg Ile Ile Lys Gln Leu Gln Asn Pro Asp Met Ala Leu
                 310                 315                 320

 tgc cca cat ttt gct gcc tcg gaa ggt tta atc aac atg tag ttgccca     1184
 Cys Pro His Phe Ala Ala Ser Glu Gly Leu Ile Asn Met 
             325                 330

 cgccggtttt aatggatacc ctggaacact gcctcattgt cttgttagat ctctgcttag   1244

 gtcgcagctc acgcattgaa tgcacacagt gattgtatgc atgccttttg gtacagtgtt   1304

 ttcatctctt ggtcataatt ccgagatccc cagagaccac tgtttctgga gtatctgtca   1364

 tccagtgact gctcatattg tggcattatg cagtgttaca tcttgccttg atacccaggt   1424

 atggagagag ttttctattt ttttagactt tttttcctct ccctcataat tcagcattaa   1484

 agaattgtat ttctctagct gtattttgta tgtaagaggt ttagctgaat ctcattctgt   1544

 gaaagccttt taatttattg aaatgtttca tgactactgc tgctagctct tcaagccagg   1604

 ttcatgcttg gacctcattc tgataaagta taagacttta aaat                    1648




      <210> 347
      <211> 1223
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(1176)

      <400> 347
 taagaaccgg gcagcccggc cgtggatcat cactatgggg caccggccca tgtactgctc     60

 caacgcagat ctggacgact gcacacgaca tgaaagcaag gtccgcaaag gcctccaagg    120

 caagctgtac gggttggagg atcttttcta caaatatgga gtggatctgc agctgtgggc    180

 tcatgagcac tcgtatgaac gactgtggcc aatttacaac taccaggtat ttaacggcag    240

 ccgagagatg ccctacacca acccgcgagg gcctgtccac atcatcacag gatctgctcc    300

 acagccgggc ctggcggggg gacc   atg ggc gcc tcg gtc tcc agg ggc cgg     351
                              Met Gly Ala Ser Val Ser Arg Gly Arg
                                1               5

 gcc gcc cgg gtc ccc gcg ccg gag ccg gaa ccc gaa gag gcg ctg gac      399
 Ala Ala Arg Val Pro Ala Pro Glu Pro Glu Pro Glu Glu Ala Leu Asp
  10                  15                  20                  25

 ctg agc caa cta ccc cca gag ctg ctt ctg gtg gtg ctg agc cac gtc      447
 Leu Ser Gln Leu Pro Pro Glu Leu Leu Leu Val Val Leu Ser His Val
                  30                  35                  40

 ccc ccg cgc acg ctg ctc ggg cgc tgc cgc caa gtg tgc cgg ggc tgg      495
 Pro Pro Arg Thr Leu Leu Gly Arg Cys Arg Gln Val Cys Arg Gly Trp
              45                  50                  55

 cga gcc ctg gtg gac ggc cag gcc ctg tgg ctg ctg atc ctg gcc cgc      543
 Arg Ala Leu Val Asp Gly Gln Ala Leu Trp Leu Leu Ile Leu Ala Arg
          60                  65                  70

 gac cac ggc gcc acc ggc cgc gcg ctg ctg cac ctc gcc cgc agc tgc      591
 Asp His Gly Ala Thr Gly Arg Ala Leu Leu His Leu Ala Arg Ser Cys
      75                  80                  85

 cag tct ccc gcc cgt aac gcc agg cct tgc ccc ctg ggc cgc ttc tgc      639
 Gln Ser Pro Ala Arg Asn Ala Arg Pro Cys Pro Leu Gly Arg Phe Cys
  90                  95                 100                 105

 gcg cgc aga ccc atc gga cgc aac ttt att cgc aac ccc tgc ggc caa      687
 Ala Arg Arg Pro Ile Gly Arg Asn Phe Ile Arg Asn Pro Cys Gly Gln
                 110                 115                 120

 gaa ggc ctc cga aag tgg atg gtg caa cac ggt ggg gac ggc tgg gtg      735
 Glu Gly Leu Arg Lys Trp Met Val Gln His Gly Gly Asp Gly Trp Val
             125                 130                 135

 gtg gag gaa aac agg aca acc gtg cct ggg gcc cct tct cag acg tgc      783
 Val Glu Glu Asn Arg Thr Thr Val Pro Gly Ala Pro Ser Gln Thr Cys
         140                 145                 150

 ttc gtg act tca ttc agc tgg tgt tgc aag aag cag gtc ttg gac cta      831
 Phe Val Thr Ser Phe Ser Trp Cys Cys Lys Lys Gln Val Leu Asp Leu
     155                 160                 165

 gag gag gag ggt ctg tgg cca gaa ctg ctg gat agt ggc agg att gag      879
 Glu Glu Glu Gly Leu Trp Pro Glu Leu Leu Asp Ser Gly Arg Ile Glu
 170                 175                 180                 185

 att tgt gtc tct gac tgg tgg gga gcc cga cac gac agc ggc tgt atg      927
 Ile Cys Val Ser Asp Trp Trp Gly Ala Arg His Asp Ser Gly Cys Met
                 190                 195                 200

 tac aga ctc ctc gtc caa ctt cta gac gcc aac cag act gtt cta gat      975
 Tyr Arg Leu Leu Val Gln Leu Leu Asp Ala Asn Gln Thr Val Leu Asp
             205                 210                 215

 aaa ttc tct gct gtg cct gat ccc atc ccg cag tgg aac aac aat gcc     1023
 Lys Phe Ser Ala Val Pro Asp Pro Ile Pro Gln Trp Asn Asn Asn Ala
         220                 225                 230

 tgc ctt cac gtc acc cac gtg ttc tcc aac atc aag atg ggc gtc cgc     1071
 Cys Leu His Val Thr His Val Phe Ser Asn Ile Lys Met Gly Val Arg
     235                 240                 245

 ttt gtg tct ttc gaa cac cgg ggc cag gac aca cag ttc tgg gct ggc     1119
 Phe Val Ser Phe Glu His Arg Gly Gln Asp Thr Gln Phe Trp Ala Gly
 250                 255                 260                 265

 cac tat gga gcc cgt gtg acc aac tcc agt gtg atc gtg cga gtc cgt     1167
 His Tyr Gly Ala Arg Val Thr Asn Ser Ser Val Ile Val Arg Val Arg
                 270                 275                 280

 ctg tcc tag tccagca ctacccttct tgcaagacag cctgactgtg ccttccaggg     1223
 Leu Ser 






      <210> 348
      <211> 1238
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (149)..(838)

      <400> 348
 taggatatta gattttggtt ttttctgacc ccggcttccc tttaaccttg ccagggctgg     60

 gcccaacggc cccgggcttt caccccaaca ctcgggctcg gcataaagcg gccgccggcc    120

 gccggccccc agacgcgccg ccgctgcc   atg gcc cag ccc ctg tgc ccg ccg     172
                                  Met Ala Gln Pro Leu Cys Pro Pro
                                    1               5

 ctc tcc gag tcc tgg atg ctc tct gcg gcc tgg ggc cca act cgg cgg      220
 Leu Ser Glu Ser Trp Met Leu Ser Ala Ala Trp Gly Pro Thr Arg Arg
      10                  15                  20

 ccg ccg ccc tcc gac aag gac tgc ggc cgc tcc ctc gtc tcg tcc cca      268
 Pro Pro Pro Ser Asp Lys Asp Cys Gly Arg Ser Leu Val Ser Ser Pro
  25                  30                  35                  40

 gac tca tgg ggc agc acc cca gcc gac agc ccc gtg gcg agc ccc gcg      316
 Asp Ser Trp Gly Ser Thr Pro Ala Asp Ser Pro Val Ala Ser Pro Ala
                  45                  50                  55

 cgg cca ggc acc ctc cgg gac ccc cgc gcc ccc tcc gta ggt agg cgc      364
 Arg Pro Gly Thr Leu Arg Asp Pro Arg Ala Pro Ser Val Gly Arg Arg
              60                  65                  70

 ggc gcg cgc agc agc cgc ctg ggc agc ggg cag agg cag agc gcc agt      412
 Gly Ala Arg Ser Ser Arg Leu Gly Ser Gly Gln Arg Gln Ser Ala Ser
          75                  80                  85

 gag cgg gag aaa ctg cgc atg cgc acg ctg gcc cgc gcc ctg cac gag      460
 Glu Arg Glu Lys Leu Arg Met Arg Thr Leu Ala Arg Ala Leu His Glu
      90                  95                 100

 ctg cgc cgc ttt cta ccg ccg tcc gtg gcg ccc gcg ggc cag agc ctg      508
 Leu Arg Arg Phe Leu Pro Pro Ser Val Ala Pro Ala Gly Gln Ser Leu
 105                 110                 115                 120

 acc aag atc gag acg ctg cgc ctg gct atc cgc tat atc ggc cac ctg      556
 Thr Lys Ile Glu Thr Leu Arg Leu Ala Ile Arg Tyr Ile Gly His Leu
                 125                 130                 135

 tcg gcc gtg cta ggc ctc agc gag gag agt ctc cag cgc cgg tgc cgg      604
 Ser Ala Val Leu Gly Leu Ser Glu Glu Ser Leu Gln Arg Arg Cys Arg
             140                 145                 150

 cag cgc ggt gac gcg ggg tcc cct cgg ggc tgc ccg ctg tgc ccc gac      652
 Gln Arg Gly Asp Ala Gly Ser Pro Arg Gly Cys Pro Leu Cys Pro Asp
         155                 160                 165

 gac tgc ccc gcg cag atg cag aca cgg acg cag gct gag ggg cag ggg      700
 Asp Cys Pro Ala Gln Met Gln Thr Arg Thr Gln Ala Glu Gly Gln Gly
     170                 175                 180

 cag ggg cgc ggg ctg ggc ctg gta tcc gcc gtc cgc gcc ggg gcg tcc      748
 Gln Gly Arg Gly Leu Gly Leu Val Ser Ala Val Arg Ala Gly Ala Ser
 185                 190                 195                 200

 tgg gga tcc ccc gcc tgc ctg ccc cgg agc ccg agc tgc acc cga gcc      796
 Trp Gly Ser Pro Ala Cys Leu Pro Arg Ser Pro Ser Cys Thr Arg Ala
                 205                 210                 215

 gcg cga ccc gcc tgc gct gtt cgc cga ggc ggc gtg ccc tga agggcag      845
 Ala Arg Pro Ala Cys Ala Val Arg Arg Gly Gly Val Pro 
             220                 225

 gcgatggagc caagcccacc gtccccgctc cttccgggcg acgtgctggc tttgttggaa    905

 acctggatgc cccttttgcc tttggagtgg ctgccttagg agcccaaatt acaaaggaca    965

 acttaccccg tttttgttaa caccgaggct ttttggcctc agcacctttg aagtggttcc   1025

 ttggcaaact gccttttctg gaaaagggca cgggcgattc cgacgggggc atttcttcgg   1085

 gttaaaaccg tccccccccc ggcggccctt ttcagcccct ccctccatgg aaggacccat   1145

 aagggtaaac ccttttaggc aaacaggagg ctttgcctaa tgttaattta tttatttgtg   1205

 aataaaatgg actggtgtca aaaaaaaaaa aaa                                1238




      <210> 349
      <211> 624
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (77)..(319)

      <400> 349
 ggtcgacgat ttcgtctgac ttgcagatgc tgtgagatcc agagctaaga ctccaggaca     60

 tcccggaagc cgaaaa    atg gaa ctg ttg aca ttc agg gat gtg acc ata     109
                      Met Glu Leu Leu Thr Phe Arg Asp Val Thr Ile
                        1               5                  10

 gaa ttc tct ctg gag gag tgg gag ttt ctg aac cct gct cag cag agt      157
 Glu Phe Ser Leu Glu Glu Trp Glu Phe Leu Asn Pro Ala Gln Gln Ser
              15                  20                  25

 ttg tat agg aaa gtg atg cta gag aac tac aga aac ctg gtc tct ctg      205
 Leu Tyr Arg Lys Val Met Leu Glu Asn Tyr Arg Asn Leu Val Ser Leu
          30                  35                  40

 ggt ctt act gtt tct aag cca gaa ctg att agc cgt ctg gag caa aga      253
 Gly Leu Thr Val Ser Lys Pro Glu Leu Ile Ser Arg Leu Glu Gln Arg
      45                  50                  55

 cag gag ccc tgg aat gtg aag aga cat gag acc ata gcc aaa ccc cca      301
 Gln Glu Pro Trp Asn Val Lys Arg His Glu Thr Ile Ala Lys Pro Pro
  60                  65                  70                  75

 ggt agg ttg gat gaa tga aacaca tgccacaggt gaaagctcca aaggccaaga      355
 Gly Arg Leu Asp Glu 
                  80

 aggaagacag acttcaagag ttatttgaga agctctgctc caatggagat gatttttgag    415

 gaacgtgatt gtttattctt gctcttgtac agaggcatct tctgtctaat gctcctaaat    475

 tctctaaaaa gtaaccttac tttgaggtta tagtgagagc caaagtcctc ttcatggctt    535

 ataagagact ttattatctg actgcccttt cattgtcttg gggcacacag aaatatatgt    595

 gtatttttga ggaactctat gttaaacta                                      624




      <210> 350
      <211> 3245
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (402)..(2537)

      <400> 350
 cctgcaacaa agcgaggctt gcgcagggcg caaaaaagca gtcagagggt ggcgcctttt     60

 ttaaagaagt ttccatcctc tctgtcctaa agctcaggcc gttccccacc cccaccgctc    120

 gctagccttc tgttcccagt cccctggcat gatctgatcg cctttgaagc aggtacccgc    180

 ctcggtctcc ccatcagctc caggggcctc tcagttgagt gggtggagcc gacagaagcc    240

 gcgggctgag ctcaagggcc gatgggaggg gtcctggggg cgctaactgc gcaccgcggc    300

 catgacgctg ggcagatcat tcacagaagt ctctgtctcc tttcatctac agtcgcagct    360

 gttttccaga cgccttgctc ctcaggtcgg ggagtgatct g    atg gcc cag gtt     413
                                                  Met Ala Gln Val
                                                    1

 cga gaa act tct ttg ccc tcc ggc tct ggg gtc cgc tgg atc tcc gga      461
 Arg Glu Thr Ser Leu Pro Ser Gly Ser Gly Val Arg Trp Ile Ser Gly
   5                  10                  15                  20

 ggt ggg gga gga gcc tct cct gag gag gcg gtt gag aag gcg ggg aaa      509
 Gly Gly Gly Gly Ala Ser Pro Glu Glu Ala Val Glu Lys Ala Gly Lys
                  25                  30                  35

 atg gag gag gcg gcg gcg ggg gct acg aag gcg tct tcg aga cgt gaa      557
 Met Glu Glu Ala Ala Ala Gly Ala Thr Lys Ala Ser Ser Arg Arg Glu
              40                  45                  50

 gcc gag gag atg aag ctg gag cca tta caa gag cgt gag ccc gcg ccg      605
 Ala Glu Glu Met Lys Leu Glu Pro Leu Gln Glu Arg Glu Pro Ala Pro
          55                  60                  65

 gag gag aac ttg acg tgg agc agc agc ggc ggc gac gag aag gtg ctc      653
 Glu Glu Asn Leu Thr Trp Ser Ser Ser Gly Gly Asp Glu Lys Val Leu
      70                  75                  80

 cct tca atc ccc ctt cgc tgt cac agc agc tcc tcg ccc gtt tgc ccg      701
 Pro Ser Ile Pro Leu Arg Cys His Ser Ser Ser Ser Pro Val Cys Pro
  85                  90                  95                 100

 cgc cgc aag ccc cgc cct cgg ccc cag ccc cgg gcc cgc tcc cgc agc      749
 Arg Arg Lys Pro Arg Pro Arg Pro Gln Pro Arg Ala Arg Ser Arg Ser
                 105                 110                 115

 cag cct ggg ctc tcg gcc cca ccc ccg cct cca gcc cgg ccc ccg ccc      797
 Gln Pro Gly Leu Ser Ala Pro Pro Pro Pro Pro Ala Arg Pro Pro Pro
             120                 125                 130

 ccg ccg cca ccc ccg ccc cca ccc gca ccg cgg ccc agg gcc tgg cgt      845
 Pro Pro Pro Pro Pro Pro Pro Pro Ala Pro Arg Pro Arg Ala Trp Arg
         135                 140                 145

 gga tcc cgg cgc aga tcc cgg cct ggg tcc agg cct cag aca cgg aga      893
 Gly Ser Arg Arg Arg Ser Arg Pro Gly Ser Arg Pro Gln Thr Arg Arg
     150                 155                 160

 agc tgc tct ggt gac cta gac ggg tcg ggg gat cct ggc ggc tta ggg      941
 Ser Cys Ser Gly Asp Leu Asp Gly Ser Gly Asp Pro Gly Gly Leu Gly
 165                 170                 175                 180

 gac tgg ttg ctg gag gtc gag ttt ggt cag ggt ccc aca ggc tgc tct      989
 Asp Trp Leu Leu Glu Val Glu Phe Gly Gln Gly Pro Thr Gly Cys Ser
                 185                 190                 195

 cat gtg gag agc ttt aaa gta ggt aag aac tgg cag aag aac ctg agg     1037
 His Val Glu Ser Phe Lys Val Gly Lys Asn Trp Gln Lys Asn Leu Arg
             200                 205                 210

 ttg atc tac cag cgt ttc gtt tgg agt ggg acc cca gag act agg aaa     1085
 Leu Ile Tyr Gln Arg Phe Val Trp Ser Gly Thr Pro Glu Thr Arg Lys
         215                 220                 225

 cgt aaa gca aag tca tgc atc tgt cac gta tgt agt acc cat atg aac     1133
 Arg Lys Ala Lys Ser Cys Ile Cys His Val Cys Ser Thr His Met Asn
     230                 235                 240

 aga ctc cac tct tgt ctc tcc tgt gtc ttt ttt ggc tgc ttc act gag     1181
 Arg Leu His Ser Cys Leu Ser Cys Val Phe Phe Gly Cys Phe Thr Glu
 245                 250                 255                 260

 aaa cat att cac aaa cat gca gaa aca aag cag cac cat tta gct gta     1229
 Lys His Ile His Lys His Ala Glu Thr Lys Gln His His Leu Ala Val
                 265                 270                 275

 gac ctt tat cat ggg gtc ata tat tgc ttc atg tgt aag gat tat gta     1277
 Asp Leu Tyr His Gly Val Ile Tyr Cys Phe Met Cys Lys Asp Tyr Val
             280                 285                 290

 tat gac aaa gac ata gaa cag att gcc aaa gaa aca aaa gaa aaa att     1325
 Tyr Asp Lys Asp Ile Glu Gln Ile Ala Lys Glu Thr Lys Glu Lys Ile
         295                 300                 305

 ttg aga tta tta act tcc acc tca aca gat gtt tct cat caa cag ttt     1373
 Leu Arg Leu Leu Thr Ser Thr Ser Thr Asp Val Ser His Gln Gln Phe
     310                 315                 320

 atg aca tca ggg ttt gaa gac aag caa tca acc tgt gag aca aag gaa     1421
 Met Thr Ser Gly Phe Glu Asp Lys Gln Ser Thr Cys Glu Thr Lys Glu
 325                 330                 335                 340

 cag gag cca aaa ttg gtg aaa ccc aag aaa aag aga aga aaa aag tca     1469
 Gln Glu Pro Lys Leu Val Lys Pro Lys Lys Lys Arg Arg Lys Lys Ser
                 345                 350                 355

 gtc tat act gta ggc ctg aga ggg cta atc aat ctt ggg aac act tgt     1517
 Val Tyr Thr Val Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr Cys
             360                 365                 370

 ttt atg aat tgt att gtc cag gca ctt acc cat att cct cta ctg aaa     1565
 Phe Met Asn Cys Ile Val Gln Ala Leu Thr His Ile Pro Leu Leu Lys
         375                 380                 385

 gat ttc ttc ctc tct gac aag cac aaa tgt ata atg aca agc ccc agc     1613
 Asp Phe Phe Leu Ser Asp Lys His Lys Cys Ile Met Thr Ser Pro Ser
     390                 395                 400

 ttg tgt ctg gtc tgt gaa atg tct tcg ctt ttt cat gct atg tac tct     1661
 Leu Cys Leu Val Cys Glu Met Ser Ser Leu Phe His Ala Met Tyr Ser
 405                 410                 415                 420

 ggg agc cga act cct cac att ccc tat aag tta ctg cat ctg ata tgg     1709
 Gly Ser Arg Thr Pro His Ile Pro Tyr Lys Leu Leu His Leu Ile Trp
                 425                 430                 435

 atc cat gca gaa cat tta gca ggg tac agg cag cag gat gcc cat gag     1757
 Ile His Ala Glu His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His Glu
             440                 445                 450

 ttc ctt att gca ata tta gac gtg cta cat aga cac agc aaa gat gat     1805
 Phe Leu Ile Ala Ile Leu Asp Val Leu His Arg His Ser Lys Asp Asp
         455                 460                 465

 agt ggt ggg cag gag gcc aat aac ccc aac tgc tgt aac tgc atc ata     1853
 Ser Gly Gly Gln Glu Ala Asn Asn Pro Asn Cys Cys Asn Cys Ile Ile
     470                 475                 480

 gac caa atc ttt aca ggt ggc ctg caa tca gat gtc aca tgt caa gcc     1901
 Asp Gln Ile Phe Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln Ala
 485                 490                 495                 500

 tgc cat agt gtt tct acc acc ata gac cca tgc tgg gac atc agt ttg     1949
 Cys His Ser Val Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser Leu
                 505                 510                 515

 gac ttg cct ggc tct tgt gcc aca ttc gat tcc cag aac cca gag agg     1997
 Asp Leu Pro Gly Ser Cys Ala Thr Phe Asp Ser Gln Asn Pro Glu Arg
             520                 525                 530

 gct gac agc aca gtg agc agg gat gac cac ata cca gga atc ccc tca     2045
 Ala Asp Ser Thr Val Ser Arg Asp Asp His Ile Pro Gly Ile Pro Ser
         535                 540                 545

 ctt aca gac tgt cta cag tgg ttt aca agg cca gag cac cta gga agc     2093
 Leu Thr Asp Cys Leu Gln Trp Phe Thr Arg Pro Glu His Leu Gly Ser
     550                 555                 560

 agt gcc aaa atc aaa tgc aat agt tgc caa agc tac cag gag tct act     2141
 Ser Ala Lys Ile Lys Cys Asn Ser Cys Gln Ser Tyr Gln Glu Ser Thr
 565                 570                 575                 580

 aaa cag ctc aca atg aaa aaa tta ccc att gtg gct tgt ttt cat ctc     2189
 Lys Gln Leu Thr Met Lys Lys Leu Pro Ile Val Ala Cys Phe His Leu
                 585                 590                 595

 aag cgg ttt gag cat gta ggc aaa cag agg cga aag att aat acc ttt     2237
 Lys Arg Phe Glu His Val Gly Lys Gln Arg Arg Lys Ile Asn Thr Phe
             600                 605                 610

 atc tcc ttt ccc ttg gag ctg gac atg act ccg ttt ttg gcc tct act     2285
 Ile Ser Phe Pro Leu Glu Leu Asp Met Thr Pro Phe Leu Ala Ser Thr
         615                 620                 625

 aaa gag agc aga atg aaa gaa ggc cag cca cca aca gat tgt gtg ccc     2333
 Lys Glu Ser Arg Met Lys Glu Gly Gln Pro Pro Thr Asp Cys Val Pro
     630                 635                 640

 aat gag aat aag tat tcc ttg ttt gca gtg att aat cac cat gga act     2381
 Asn Glu Asn Lys Tyr Ser Leu Phe Ala Val Ile Asn His His Gly Thr
 645                 650                 655                 660

 ttg gaa agt ggc cac tat acc agc ttc atc cgg caa caa aag gac cag     2429
 Leu Glu Ser Gly His Tyr Thr Ser Phe Ile Arg Gln Gln Lys Asp Gln
                 665                 670                 675

 tgg ttc agc tgt gat gat gcc atc atc acc aag gct acc att gag gac     2477
 Trp Phe Ser Cys Asp Asp Ala Ile Ile Thr Lys Ala Thr Ile Glu Asp
             680                 685                 690

 tta ctc tac agt gaa ggg tat tta ctg ttc tat cac aaa cag ggt cta     2525
 Leu Leu Tyr Ser Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Gly Leu
         695                 700                 705

 gag aaa gac tag tct taccagacca cttactgaaa aaaaagtaaa tgattaggca     2580
 Glu Lys Asp 
     710

 aggattttga agtgacacac agacctactt ggaatggaca atgacagtaa cacctatgtg   2640

 acagctagta tcttgatata aagaacctat tttagcatgg cccatgggtc tgtcggaaga   2700

 aaaaaatgaa tactaaccag tgaccattca accttaagaa atggggagag ggagaagagg   2760

 ttgaaaatgg tcacataaag cataatgaaa tgaaaagaat gctttaggtg gggacaacgg   2820

 gagtagaagt gttctgatgc tactctatgt catttgtttt tacagaaata tcttgtgaag   2880

 tcagggagta ttcctttatc agcaaaaact tcacaattgg tgttccagct gtggctgacc   2940

 agctaaatag tttgaaagaa aaataatatt ttaaaataaa gtttaaagag ctttaaaaga   3000

 aaaacattta aaaaggaaaa aatcattttt aagattttaa aagaaaaaaa cttttaaatg   3060

 ttgaaaaaaa tttaagttgt tatttttaaa agaaatattt taaaagttaa aaataatttt   3120

 ttaatttaaa gaagtttcag aattttaaaa attaaaagca aagaaaatta aattcttaaa   3180

 gtttaaaaat gtaaaataaa ttaaggaaca aggttaaaaa tgaaagttta ccaaaaaaaa   3240

 aaaaa                                                               3245




      <210> 351
      <211> 1265
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (535)..(1218)

      <400> 351
 tgcatccctg tgggaactgc cctccacctg ctccctgggg acacgtccag gtcgtacccg     60

 cagtgcgtcc ctgtgggaac tgccctccac ctgctccctg gggacaagtc caggtcgtac    120

 ccgcagtgcg tccctgtggg aactgccctc cacctgctcc ctggggacaa gtccaggtcg    180

 tacccgcagt gcgtccctgt gggaactgcc ctccacctgc tccctgggga caagtccagg    240

 tcgtacccgc agtgcgtccc tgtgggacct gccctccacc tgctccatgg ggacaagtcc    300

 aggtcgtacc cgcagtgcgt ccctgtggga actgccctcc acctgctccc tggggacacg    360

 tccaggtcgt acccgcagtg cgtccctgtg ggaactgccc tccacctgct ccctggggac    420

 acgtccaggt cgtacccgca gtgcgtccct gtgggaactg ccctccacct gctccctggg    480

 gacacgtcca ggtcgtaccc gcagtgcgga gaggtcgggt cacagccagc agct  atg     537
                                                              Met
                                                                1

 tct gac ata aat ctt gac tgg gtt gac agg cgt cag ttg cag cgc ttg      585
 Ser Asp Ile Asn Leu Asp Trp Val Asp Arg Arg Gln Leu Gln Arg Leu
               5                  10                  15

 gag gaa atg ctg att gtt gtg gat gag aat gat aag gtt att ggt gcc      633
 Glu Glu Met Leu Ile Val Val Asp Glu Asn Asp Lys Val Ile Gly Ala
          20                  25                  30

 gac acc aag agg aat tgc cat ctg aac gaa aac att gag aaa ggg ctg      681
 Asp Thr Lys Arg Asn Cys His Leu Asn Glu Asn Ile Glu Lys Gly Leu
      35                  40                  45

 ctg cac cga gcc ttc agc gtt gtc ttg ttt aac acc aag aat cga atc      729
 Leu His Arg Ala Phe Ser Val Val Leu Phe Asn Thr Lys Asn Arg Ile
  50                  55                  60                  65

 ctg ata cag cag agg tcg gac acg aaa gtc acg ttt cct ggg tat ttt      777
 Leu Ile Gln Gln Arg Ser Asp Thr Lys Val Thr Phe Pro Gly Tyr Phe
                  70                  75                  80

 acc gac tcc tgt agt agc cac cca tta tac aac cca gca gaa ctg gaa      825
 Thr Asp Ser Cys Ser Ser His Pro Leu Tyr Asn Pro Ala Glu Leu Glu
              85                  90                  95

 gaa aag gat gcc atc gga gtg agg agg gca gcc cag agg cgt ctg caa      873
 Glu Lys Asp Ala Ile Gly Val Arg Arg Ala Ala Gln Arg Arg Leu Gln
         100                 105                 110

 gca gag ctg gga att cct ggg gag cag att tct cca gag gac att gtg      921
 Ala Glu Leu Gly Ile Pro Gly Glu Gln Ile Ser Pro Glu Asp Ile Val
     115                 120                 125

 ttc atg aca atc tat cac cac aag gca aaa tca gac aga att tgg gga      969
 Phe Met Thr Ile Tyr His His Lys Ala Lys Ser Asp Arg Ile Trp Gly
 130                 135                 140                 145

 gag cat gaa att tgt tac ctt ctg ctt gtg agg aaa aac gtc act ctg     1017
 Glu His Glu Ile Cys Tyr Leu Leu Leu Val Arg Lys Asn Val Thr Leu
                 150                 155                 160

 aac ccg gat ccc agt gaa acg aaa agc atc ctc tac ctg tcc cag gag     1065
 Asn Pro Asp Pro Ser Glu Thr Lys Ser Ile Leu Tyr Leu Ser Gln Glu
             165                 170                 175

 gag ctg tgg gag ctg ctg gag agg gag gcg agg ggt gaa gtc aaa gtc     1113
 Glu Leu Trp Glu Leu Leu Glu Arg Glu Ala Arg Gly Glu Val Lys Val
         180                 185                 190

 acc ccc tgg cta aga acc att gcc gag agg ttt ctg tac cgg tgg tgg     1161
 Thr Pro Trp Leu Arg Thr Ile Ala Glu Arg Phe Leu Tyr Arg Trp Trp
     195                 200                 205

 cct cac ctg gat gac gtg acc ccg ttt gtg gag ctt cac aaa ata cac     1209
 Pro His Leu Asp Asp Val Thr Pro Phe Val Glu Leu His Lys Ile His
 210                 215                 220                 225

 aga gtg tga gaggcag ggaggtcgag tcagccatgt gtaatgccct cagtgcaggc     1265
 Arg Val 






      <210> 352
      <211> 1401
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (345)..(1205)

      <400> 352
 ccagctggag gaattcccgc tgctggcgag ctgtgcccca cgctcccgct gcaacagtcc     60

 cgggcatcgc agctgccagt caaggctagg aggcggtcgg ggactccgcc tcctcccgac    120

 ccgtaggtct gggagcgcaa gtcctgttgc agtcttgcaa agtgtaaagc tgtcagccgc    180

 agagcacgga ggaaagacgg agagaatgga agagctcctg tccggtgtgc cagcagcccg    240

 gactggcggt gagcgcgagg gcggctactg agaagcccgg cgacggagga acgcaggtct    300

 gctgccaggg attgaggaga ctgaagaacg ctgaagacag gctg atg ggc tca gct     356
                                                  Met Gly Ser Ala
                                                    1

 ggt agg ctc cac tat ctc gcc atg act gct gaa aat ccc act cct gga      404
 Gly Arg Leu His Tyr Leu Ala Met Thr Ala Glu Asn Pro Thr Pro Gly
   5                  10                  15                  20

 gac ctg gct ccg gcc ccc ctc atc act tgc aaa ctc tgc ctg tgt gag      452
 Asp Leu Ala Pro Ala Pro Leu Ile Thr Cys Lys Leu Cys Leu Cys Glu
                  25                  30                  35

 cag tct ctg gac aag atg acc aca ctc cag gaa tgc cag tgc atc ttt      500
 Gln Ser Leu Asp Lys Met Thr Thr Leu Gln Glu Cys Gln Cys Ile Phe
              40                  45                  50

 tgc aca gct tgc ctg aaa cag tac atg cag ctg gca atc cga gaa gga      548
 Cys Thr Ala Cys Leu Lys Gln Tyr Met Gln Leu Ala Ile Arg Glu Gly
          55                  60                  65

 tgt ggg tct ccc atc act tgc cct gac atg gtg tgc cta aac cac ggg      596
 Cys Gly Ser Pro Ile Thr Cys Pro Asp Met Val Cys Leu Asn His Gly
      70                  75                  80

 acc ctg cag gaa gct gag att gcc tgt ttg gta cct gtg gac cag ttt      644
 Thr Leu Gln Glu Ala Glu Ile Ala Cys Leu Val Pro Val Asp Gln Phe
  85                  90                  95                 100

 caa ctt tat cag agg tta aaa ttt gaa aga gaa gtt cat ctg gac ccc      692
 Gln Leu Tyr Gln Arg Leu Lys Phe Glu Arg Glu Val His Leu Asp Pro
                 105                 110                 115

 tac cga aca tgg tgt cct gtt gca gac tgt cag aca gtg tgc cct gtt      740
 Tyr Arg Thr Trp Cys Pro Val Ala Asp Cys Gln Thr Val Cys Pro Val
             120                 125                 130

 gcc tcg agt gac cca gga cag cct gtg ctg gtg gaa tgc cct tct tgc      788
 Ala Ser Ser Asp Pro Gly Gln Pro Val Leu Val Glu Cys Pro Ser Cys
         135                 140                 145

 cac ctg aaa ttc tgc tcg tgt tgc aag gat gct tgg cat gca gag gtc      836
 His Leu Lys Phe Cys Ser Cys Cys Lys Asp Ala Trp His Ala Glu Val
     150                 155                 160

 tcc tgt aga gac agt cag cct att gtc ctg cca aca gag cac cga gcc      884
 Ser Cys Arg Asp Ser Gln Pro Ile Val Leu Pro Thr Glu His Arg Ala
 165                 170                 175                 180

 ctc ttt ggg aca gat gca gaa gcc ccc att aag cag tgc cca gtt tgc      932
 Leu Phe Gly Thr Asp Ala Glu Ala Pro Ile Lys Gln Cys Pro Val Cys
                 185                 190                 195

 cgg gtt tat atc gaa cgc aat gaa ggc tgc gct cag atg atg tgc aaa      980
 Arg Val Tyr Ile Glu Arg Asn Glu Gly Cys Ala Gln Met Met Cys Lys
             200                 205                 210

 aac tgc aag cat aca ttt tgc tgg tac tgc ctc cag aac ttg gat gtc     1028
 Asn Cys Lys His Thr Phe Cys Trp Tyr Cys Leu Gln Asn Leu Asp Val
         215                 220                 225

 cca cca gga ctc tta ctt ggg gtc cat atc cac aag gag gct gag ccc     1076
 Pro Pro Gly Leu Leu Leu Gly Val His Ile His Lys Glu Ala Glu Pro
     230                 235                 240

 atg agg gtc ctc ttc aag gag gcc gaa tgt tac gga acc cac ttt gtg     1124
 Met Arg Val Leu Phe Lys Glu Ala Glu Cys Tyr Gly Thr His Phe Val
 245                 250                 255                 260

 tcc ccc gaa tgt tcc aat ccc ttg ggg ttg acc acg tgc ctt ggg gcg     1172
 Ser Pro Glu Cys Ser Asn Pro Leu Gly Leu Thr Thr Cys Leu Gly Ala
                 265                 270                 275

 gaa atg tgg ctt gca aac gac gac aac agc tag ctccagca gcccggatgc     1223
 Glu Met Trp Leu Ala Asn Asp Asp Asn Ser 
             280                 285

 gagccgggca cctggaaacc ttaacggctg gccacgtgtt aacagcgctg aataacacgg   1283

 actaccgata gcagcactct tttcacggca aaggcgtcta agaccgcctc acgattgcag   1343

 acgcaagcaa ctagtgatac agatgaacca ccagggagcc ccccatgagc agcgacga     1401




      <210> 353
      <211> 1078
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(882)

      <400> 353
 tgtccggtgt gccagcagcc cggactggcg gtgagcgcga gggaggctac tgagaagccc     60

 ggcgacggag gaacgcaggt ctgctgccag ggattgagga gactgaagaa cgctgaagac    120

 aggctg   atg ggc tca gct ggt agg ctc cac tat ctc gcc atg act gct     168
          Met Gly Ser Ala Gly Arg Leu His Tyr Leu Ala Met Thr Ala
            1               5                  10

 gaa aat ccc act cct gga gac ctg gct ccg gcc ccc ctc atc act tgc      216
 Glu Asn Pro Thr Pro Gly Asp Leu Ala Pro Ala Pro Leu Ile Thr Cys
  15                  20                  25                  30

 aaa ctc tgc ctg tgt gag cag tct ctg gac aag atg acc aca ctc cag      264
 Lys Leu Cys Leu Cys Glu Gln Ser Leu Asp Lys Met Thr Thr Leu Gln
                  35                  40                  45

 gaa tgc cag tgc atc ttt tgc aca gct att gcc tgt ttg gta cct gtg      312
 Glu Cys Gln Cys Ile Phe Cys Thr Ala Ile Ala Cys Leu Val Pro Val
              50                  55                  60

 gac cag ttt caa ctt tat cag agg tta aaa ttt gaa aga gaa gtt cat      360
 Asp Gln Phe Gln Leu Tyr Gln Arg Leu Lys Phe Glu Arg Glu Val His
          65                  70                  75

 ctg gac ccc tac cga aca tgg tgt cct gtt gca gac tgt cag aca gtg      408
 Leu Asp Pro Tyr Arg Thr Trp Cys Pro Val Ala Asp Cys Gln Thr Val
      80                  85                  90

 tgc cct gtt gcc tcg agt gac cca gga cag cct gtg ctg gtg gaa tgc      456
 Cys Pro Val Ala Ser Ser Asp Pro Gly Gln Pro Val Leu Val Glu Cys
  95                 100                 105                 110

 cct tct tgc cac ctg aaa ttc tgc tcg tgt tgc aag gat gct tgg cat      504
 Pro Ser Cys His Leu Lys Phe Cys Ser Cys Cys Lys Asp Ala Trp His
                 115                 120                 125

 gca gag gtc tcc tgt aga gac agt cag cct att gtc ctg cca aca gag      552
 Ala Glu Val Ser Cys Arg Asp Ser Gln Pro Ile Val Leu Pro Thr Glu
             130                 135                 140

 cac cga gcc ctc ttt ggg aca gat gca gaa gcc ccc att aag cag tgc      600
 His Arg Ala Leu Phe Gly Thr Asp Ala Glu Ala Pro Ile Lys Gln Cys
         145                 150                 155

 cca gtt tgc cgg gtt tat atc gaa cgc aat gaa ggc tgc gct cag atg      648
 Pro Val Cys Arg Val Tyr Ile Glu Arg Asn Glu Gly Cys Ala Gln Met
     160                 165                 170

 atg tgc aaa aac tgc aag cat aca ttt tgc tgg tac tgc ctc cag aac      696
 Met Cys Lys Asn Cys Lys His Thr Phe Cys Trp Tyr Cys Leu Gln Asn
 175                 180                 185                 190

 ttg gat gtc cca cca gga ctc tta ctt ggg gtc cat atc cac aag gag      744
 Leu Asp Val Pro Pro Gly Leu Leu Leu Gly Val His Ile His Lys Glu
                 195                 200                 205

 gct gag ccc atg agg gtc ctc ttc aag gag gcc gaa tgt tac gga acc      792
 Ala Glu Pro Met Arg Val Leu Phe Lys Glu Ala Glu Cys Tyr Gly Thr
             210                 215                 220

 cac ttt gtg tcc ccc gaa tgt tcc aat ccc ttg ggg ttg acc acg tgc      840
 His Phe Val Ser Pro Glu Cys Ser Asn Pro Leu Gly Leu Thr Thr Cys
         225                 230                 235

 ctt ggg gcg gaa atg tgg ctt gca aac gac gac aac agc tag ctccagc      889
 Leu Gly Ala Glu Met Trp Leu Ala Asn Asp Asp Asn Ser 
     240                 245                 250

 agcccggatg cgagccgggc acctggaaac cttaacggct ggccacgtgt taacagcgct    949

 gaataacacg gactaccgat agcagcactc ttttcacggc aaaggcgtct aagaccgcct   1009

 cacgattgca gacgcaagca actagtgata cagatgaacc accagggagc cccccatgag   1069

 cagcgacga                                                           1078




      <210> 354
      <211> 2179
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (455)..(1948)

      <400> 354
 atggcggatg ggctgcagga gaaaggaggg actgatgtgg cttctacctg cgtcaagtgg     60

 accagagaga gacagagatg ccattattac cacattcatt tcacagatgg ggcatggaac    120

 gcagcgacat taagtgactt gctcaaggcc aacaacttgg aagtggagga gctgggattt    180

 gaactgagcc tgatgccgga tgatgacaca aaccagcaag ctaaggattc agtctgcccc    240

 gtggggcgtc tccggctgct cccattgagc tgtctgctcg ctgtgcccgc tgtgcctgct    300

 gtgcccgcgc tgtcgccgct gctaccgcgt ctgctggacg cgggagacgc cagcgagctg    360

 gtgattggag ccctgcggag agctcaagcg cccagctctg cccgaggagc ccaggctgcc    420

 ccgtgagtcc catagttgct gcaggagtgg agcc    atg agc tgc gtc ctg ggt     472
                                          Met Ser Cys Val Leu Gly
                                            1               5

 ggt gtc atc ccc ttg ggg ctg ctg ttc ctg gtc tgc gga tcc caa ggc      520
 Gly Val Ile Pro Leu Gly Leu Leu Phe Leu Val Cys Gly Ser Gln Gly
              10                  15                  20

 tac ctc ctg ccc aac gtc act ctc tta gag gag ctg ctc agc aaa tac      568
 Tyr Leu Leu Pro Asn Val Thr Leu Leu Glu Glu Leu Leu Ser Lys Tyr
          25                  30                  35

 cag cac aac gag tct cac tcc cgg gtc cgc aga gcc atc ccc agg gag      616
 Gln His Asn Glu Ser His Ser Arg Val Arg Arg Ala Ile Pro Arg Glu
      40                  45                  50

 gac aag gag gag atc ctc atg ctg cac aac aag ctt cgg ggc cag gtg      664
 Asp Lys Glu Glu Ile Leu Met Leu His Asn Lys Leu Arg Gly Gln Val
  55                  60                  65                  70

 cag cct cag gcc tcc aac atg gag tac atg acc tgg gat gac gaa ctg      712
 Gln Pro Gln Ala Ser Asn Met Glu Tyr Met Thr Trp Asp Asp Glu Leu
                  75                  80                  85

 gag aag tct gct gca gcg tgg gcc agt cag tgc atc tgg gag cac ggg      760
 Glu Lys Ser Ala Ala Ala Trp Ala Ser Gln Cys Ile Trp Glu His Gly
              90                  95                 100

 ccc acc agt ctg ctg gtg tcc atc ggg cag aac ctg ggc gct cac tgg      808
 Pro Thr Ser Leu Leu Val Ser Ile Gly Gln Asn Leu Gly Ala His Trp
         105                 110                 115

 ggc agg tat cgc tct ccg ggg ttc cat gtg cag tcc tgg tat gac gag      856
 Gly Arg Tyr Arg Ser Pro Gly Phe His Val Gln Ser Trp Tyr Asp Glu
     120                 125                 130

 gtg aag gac tac acc tac ccc tac ccg agc gag tgc aac ccc tgg tgt      904
 Val Lys Asp Tyr Thr Tyr Pro Tyr Pro Ser Glu Cys Asn Pro Trp Cys
 135                 140                 145                 150

 cca gag agg tgc tcg ggg cct atg tgc acg cac tac aca cag ata gtt      952
 Pro Glu Arg Cys Ser Gly Pro Met Cys Thr His Tyr Thr Gln Ile Val
                 155                 160                 165

 tgg gcc acc acc aac aag atc ggt tgt gct gtg aac acc tgc cgg aag     1000
 Trp Ala Thr Thr Asn Lys Ile Gly Cys Ala Val Asn Thr Cys Arg Lys
             170                 175                 180

 atg act gtc tgg gga gaa gtt tgg gag aac gcg gtc tac ttt gtc tgc     1048
 Met Thr Val Trp Gly Glu Val Trp Glu Asn Ala Val Tyr Phe Val Cys
         185                 190                 195

 aat tat tct cca aag ggg aac tgg att gga gaa gcc ccc tac aag aat     1096
 Asn Tyr Ser Pro Lys Gly Asn Trp Ile Gly Glu Ala Pro Tyr Lys Asn
     200                 205                 210

 ggc cgg ccc tgc tct gag tgc cca ccc agc tat gga ggc agc tgc agg     1144
 Gly Arg Pro Cys Ser Glu Cys Pro Pro Ser Tyr Gly Gly Ser Cys Arg
 215                 220                 225                 230

 aac aac ttg tgt tac cga gaa gaa acc tac act cca aaa cct gaa acg     1192
 Asn Asn Leu Cys Tyr Arg Glu Glu Thr Tyr Thr Pro Lys Pro Glu Thr
                 235                 240                 245

 gac gag atg aat gag gtg gaa acg gct ccc att cct gaa gaa aac cat     1240
 Asp Glu Met Asn Glu Val Glu Thr Ala Pro Ile Pro Glu Glu Asn His
             250                 255                 260

 gtt tgg ctc caa ccg agg gtg atg aga ccc acc aag ccc aag aaa acc     1288
 Val Trp Leu Gln Pro Arg Val Met Arg Pro Thr Lys Pro Lys Lys Thr
         265                 270                 275

 tct gcg gtc aac tac atg acc caa gtc gtc aga tgt gac acc aag atg     1336
 Ser Ala Val Asn Tyr Met Thr Gln Val Val Arg Cys Asp Thr Lys Met
     280                 285                 290

 aag gac agg tgc aaa ggg tcc acg tgt aac agg tac cag tgc cca gca     1384
 Lys Asp Arg Cys Lys Gly Ser Thr Cys Asn Arg Tyr Gln Cys Pro Ala
 295                 300                 305                 310

 ggc tgc ctg aac cac aag gcg aag atc ttt gga agt ctg ttc tat gaa     1432
 Gly Cys Leu Asn His Lys Ala Lys Ile Phe Gly Ser Leu Phe Tyr Glu
                 315                 320                 325

 agc tcg tct agc ata tgc cgc gcc gcc atc cac tac ggg atc ctg gat     1480
 Ser Ser Ser Ser Ile Cys Arg Ala Ala Ile His Tyr Gly Ile Leu Asp
             330                 335                 340

 gac aag gga ggc ctg gtg gat atc acc agg aac ggg aag gtc ccc ttc     1528
 Asp Lys Gly Gly Leu Val Asp Ile Thr Arg Asn Gly Lys Val Pro Phe
         345                 350                 355

 ttc gtg aag tct gag aga cac ggc gtg cag tcc ctc agc aaa tac aaa     1576
 Phe Val Lys Ser Glu Arg His Gly Val Gln Ser Leu Ser Lys Tyr Lys
     360                 365                 370

 cct tcc agc tca ttc atg gtg tca aaa gtg aaa gtg cag gat ttg gac     1624
 Pro Ser Ser Ser Phe Met Val Ser Lys Val Lys Val Gln Asp Leu Asp
 375                 380                 385                 390

 tgc tac acg acc gtt gct cag ctg tgc ccg ttt gaa aag cca gca act     1672
 Cys Tyr Thr Thr Val Ala Gln Leu Cys Pro Phe Glu Lys Pro Ala Thr
                 395                 400                 405

 cac tgc cca aga atc cat tgt ccg gca cac tgc aaa gac gaa cct tcc     1720
 His Cys Pro Arg Ile His Cys Pro Ala His Cys Lys Asp Glu Pro Ser
             410                 415                 420

 tac tgg gct ccg gtg ttt gga acc aac atc tat gca gat acc tca agc     1768
 Tyr Trp Ala Pro Val Phe Gly Thr Asn Ile Tyr Ala Asp Thr Ser Ser
         425                 430                 435

 atc tgc aag aca gcc gtg cac gcg gga gtc atc agc aac gag agt ggg     1816
 Ile Cys Lys Thr Ala Val His Ala Gly Val Ile Ser Asn Glu Ser Gly
     440                 445                 450

 ggt gac gtg gac gtg atg ccc gtg gat aaa aag aag acc tac gtg ggc     1864
 Gly Asp Val Asp Val Met Pro Val Asp Lys Lys Lys Thr Tyr Val Gly
 455                 460                 465                 470

 tcg ctc agg aat gga gtt cag tct gaa agc ctg ggg act cct cgg gat     1912
 Ser Leu Arg Asn Gly Val Gln Ser Glu Ser Leu Gly Thr Pro Arg Asp
                 475                 480                 485

 gga aag gcc ttc cgg atc ttt gct gtc agg cag tga attt ccagcaccag     1962
 Gly Lys Ala Phe Arg Ile Phe Ala Val Arg Gln 
             490                 495

 gggagaaggg gcgtcttcag gagggcttcg gggttttgct tttattttta ttttgtcatt   2022

 gcggggtata tggagagtca ggaaacttcc tttgactgat gttcagtgtc catcactttg   2082

 tggcctgtgg gtgaggtgac atctcatccc ctcactgaag caacagcatc ccaaggtgct   2142

 cagccggact ccctggtgcc tgatctctgc tgggccg                            2179




      <210> 355
      <211> 2321
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (305)..(1381)

      <400> 355
 cgagctccag ccctcagcgc atgccaggac gagtcgcctg agggaactga tctcagctcg     60

 ggcccgcgtt acatcctcct cctcttcttc cttcggccca gctttcctta ggggctgcaa    120

 cccggacgcc gaggccggtt tcggagtggg gagtgcccat tttctctcct tcccacgttc    180

 ctggccccca gacgccattt gcaggcgggt ggcttgggtc agcctccccg cccccacccg    240

 actcccgtca cgggagagcg cacaccgcgc cccgagaacc aatcagcagc cgcgttaggt    300

 aacc atg tct gag tct gga cac agt cag cct gga ctc tat ggg ata gag     349
      Met Ser Glu Ser Gly His Ser Gln Pro Gly Leu Tyr Gly Ile Glu
        1               5                  10                  15

 cgg cgg cga cgg tgg aag gag cct ggc tct ggt ggc ccc cag aat ctc      397
 Arg Arg Arg Arg Trp Lys Glu Pro Gly Ser Gly Gly Pro Gln Asn Leu
                  20                  25                  30

 tct ggg cct ggt ggt cgg gag agg gac tac att gca cca tgg gaa aga      445
 Ser Gly Pro Gly Gly Arg Glu Arg Asp Tyr Ile Ala Pro Trp Glu Arg
              35                  40                  45

 gag aga agg gat gcc agc gaa gag aca agc act tcc gtc atg cag aaa      493
 Glu Arg Arg Asp Ala Ser Glu Glu Thr Ser Thr Ser Val Met Gln Lys
          50                  55                  60

 acc ccc atc atc ctc tca aaa cct cca gca gag cgg tca aaa cag cca      541
 Thr Pro Ile Ile Leu Ser Lys Pro Pro Ala Glu Arg Ser Lys Gln Pro
      65                  70                  75

 cca cct cca aca gcc cct gct gcc ccg cct gct cca gcc cct ctg gag      589
 Pro Pro Pro Thr Ala Pro Ala Ala Pro Pro Ala Pro Ala Pro Leu Glu
  80                  85                  90                  95

 aag ccc atc gtt ctc atg aag cca cgg gag gag ggg aag ggg cct gtg      637
 Lys Pro Ile Val Leu Met Lys Pro Arg Glu Glu Gly Lys Gly Pro Val
                 100                 105                 110

 gcc gtg aca ggt gcc tct acc cct gag ggc acc gcc cca cca ccc cct      685
 Ala Val Thr Gly Ala Ser Thr Pro Glu Gly Thr Ala Pro Pro Pro Pro
             115                 120                 125

 gca gcc cct gcg cca ccc aag ggg gag aag gag ggg cag aga ccc aca      733
 Ala Ala Pro Ala Pro Pro Lys Gly Glu Lys Glu Gly Gln Arg Pro Thr
         130                 135                 140

 cag cct gtg tac cag atc cag aac cgg ggc atg ggc act gcc gca cca      781
 Gln Pro Val Tyr Gln Ile Gln Asn Arg Gly Met Gly Thr Ala Ala Pro
     145                 150                 155

 gca gcc atg gac cct gtc gtg ggt cag gcc aaa cta ctg ccc cca gag      829
 Ala Ala Met Asp Pro Val Val Gly Gln Ala Lys Leu Leu Pro Pro Glu
 160                 165                 170                 175

 cgc atg aag cac agc atc aag ttg gtg gat gac cag atg aat tgg tgt      877
 Arg Met Lys His Ser Ile Lys Leu Val Asp Asp Gln Met Asn Trp Cys
                 180                 185                 190

 gac agt gcc atc gag tac ctg ttg gat cag act gat gtg ttg gtg gtt      925
 Asp Ser Ala Ile Glu Tyr Leu Leu Asp Gln Thr Asp Val Leu Val Val
             195                 200                 205

 ggt gtc ctg ggc ctc cag ggg aca ggc aag tcc atg gtc atg tca ttg      973
 Gly Val Leu Gly Leu Gln Gly Thr Gly Lys Ser Met Val Met Ser Leu
         210                 215                 220

 ttg tca gcc aac act cca gag gag gac cag agg act tat gtt ttc cgg     1021
 Leu Ser Ala Asn Thr Pro Glu Glu Asp Gln Arg Thr Tyr Val Phe Arg
     225                 230                 235

 gcc cag agc gct gaa atg aag gaa cga ggg ggc aac cag acc agt ggc     1069
 Ala Gln Ser Ala Glu Met Lys Glu Arg Gly Gly Asn Gln Thr Ser Gly
 240                 245                 250                 255

 atc gac ttc ttt att acc caa gaa cgg att gtt ttc ctg gac aca cag     1117
 Ile Asp Phe Phe Ile Thr Gln Glu Arg Ile Val Phe Leu Asp Thr Gln
                 260                 265                 270

 ccc atc ctg agc cct tct atc cta gac cat ctc atc aat aat gac cgc     1165
 Pro Ile Leu Ser Pro Ser Ile Leu Asp His Leu Ile Asn Asn Asp Arg
             275                 280                 285

 aaa ctg cct cca gag tac aac ctt ccc cac act tac gtt gaa atg cag     1213
 Lys Leu Pro Pro Glu Tyr Asn Leu Pro His Thr Tyr Val Glu Met Gln
         290                 295                 300

 tca ctc cag att gct gcc ttc ctt ttc acg gtc tgc cat gtg gtg att     1261
 Ser Leu Gln Ile Ala Ala Phe Leu Phe Thr Val Cys His Val Val Ile
     305                 310                 315

 gtt gtc cag gac tgg ttc aca gac ctc agt ctc tac agg ttc ctg cag     1309
 Val Val Gln Asp Trp Phe Thr Asp Leu Ser Leu Tyr Arg Phe Leu Gln
 320                 325                 330                 335

 aca gca gag atg ggt gaa ggc ctc caa ccc atc ccc cag cca cga gtc     1357
 Thr Ala Glu Met Gly Glu Gly Leu Gln Pro Ile Pro Gln Pro Arg Val
                 340                 345                 350

 cag cag ctc atc ggg ctc cga tga aggcaccgag tactaccccc acctagtctt    1411
 Gln Gln Leu Ile Gly Leu Arg 
             355

 cttgcagaac aaagctcgcc gagaggactt ctgtcctcgg aagctgcggc agatgcacct   1471

 gatgattgac cagctcatgg cccactccca cctgcgttac aagggaactc tgtccatgtt   1531

 acaatgcaat gtcttcccgg ggcttccacc tgacttcctg gactctgagg tcaacttatt   1591

 cctggtaccc ttcatggaca gtgaagcaga gagtgaaaac ccaccaagag caggacctgg   1651

 ttccagccca ctcttctccc tgctgcctgg gtatcgtggc caccccagtt tccagtcctt   1711

 ggtgagcaag ctccggagcc aagtgatgtc catggcccgg ccacagctgt cacacacgat   1771

 cctcaccgag aagaactggt tccactacgc tgcccggatc tgggatgggg tgagaaagtc   1831

 ctctgctctg gcagagtaca gccgcctgct ggcctgaggc caaggagagg aatgtcatgc   1891

 aggggacctc ctgggtccgc agtgtactgc gagggagcac agatgtccat cccccgctgg   1951

 ggtggagagc ggcagcaggc ctgatggatg agggatcgtg gcttcccggc ccagagacat   2011

 gaggtgtcca gggccaggcc ccccaccctc agttggggct gttccggggg tgactgtgag   2071

 cgatcccacc ccaaacctga gatggggtag cccgtcctgt gtcctccaca gggacaagca   2131

 gtgggaggag tctgaatggt caccaggaag cccgggctcc atcttgacct cctttttcag   2191

 ggacaggagc aacaggcccc tcttccctga ctctaagccc ttccctgtaa ggtgaggcag   2251

 ggtctggaga gctctttatt ggaacagatc tggtggttca aataaacaca gtcatgcaaa   2311

 aaaaaaaaaa                                                          2321




      <210> 356
      <211> 1474
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (231)..(1196)

      <400> 356
 gctagctccc cgccgggctc gcgccgcaga ggccggtgag gcgccggcgg ccacgccgcg     60

 gaaggcgcgg gccgagcaga gccgggcgtt ggagcccgcg cgcgcatgga ggcgttgccg    120

 gcagccccct gagggcagcg gggagacaag acccggcgac ctcgcgcatc cctcgagccg    180

 ccacgcgctc tcgccaccgg gcggcgacgg gccgcggagc cggcgcggcc   atg gcg     236
                                                          Met Ala
                                                            1

 acg ggc ggc cag cag aag gag aac acg ctg ctt cac ctc ttc gcc ggc      284
 Thr Gly Gly Gln Gln Lys Glu Asn Thr Leu Leu His Leu Phe Ala Gly
           5                  10                  15

 ggg tgt gga ggc aca gtt ggt gct att ttc act tgt cca cta gaa gtc      332
 Gly Cys Gly Gly Thr Val Gly Ala Ile Phe Thr Cys Pro Leu Glu Val
      20                  25                  30

 att aag aca cgg ttg cag tct tca aga tta gct ctc cgg aca gtc tac      380
 Ile Lys Thr Arg Leu Gln Ser Ser Arg Leu Ala Leu Arg Thr Val Tyr
  35                  40                  45                  50

 tat cct cag gtt cat ctg ggg acc att agt gga gct gga atg gtg aga      428
 Tyr Pro Gln Val His Leu Gly Thr Ile Ser Gly Ala Gly Met Val Arg
                  55                  60                  65

 cca aca tcc gtg aca cct gga ctc ttt cag gtt ctg aag tcg atc ttg      476
 Pro Thr Ser Val Thr Pro Gly Leu Phe Gln Val Leu Lys Ser Ile Leu
              70                  75                  80

 gag aaa gag gga cca aag tca ctt ttt aga ggc ttg ggt cca aat ttg      524
 Glu Lys Glu Gly Pro Lys Ser Leu Phe Arg Gly Leu Gly Pro Asn Leu
          85                  90                  95

 gtt gga gtt gca cca tca agg gct gta tac ttt gca tgt tac tcc aaa      572
 Val Gly Val Ala Pro Ser Arg Ala Val Tyr Phe Ala Cys Tyr Ser Lys
     100                 105                 110

 gcc aaa gag caa ttt aat ggc att ttc gtg cct aac agc aat att gtg      620
 Ala Lys Glu Gln Phe Asn Gly Ile Phe Val Pro Asn Ser Asn Ile Val
 115                 120                 125                 130

 cat att ttc tca gct ggc tct gca gct ttt atc aca aat tcc tta atg      668
 His Ile Phe Ser Ala Gly Ser Ala Ala Phe Ile Thr Asn Ser Leu Met
                 135                 140                 145

 aat cct ata tgg atg gtt aaa acc cga atg cag cta gaa cag aaa gtg      716
 Asn Pro Ile Trp Met Val Lys Thr Arg Met Gln Leu Glu Gln Lys Val
             150                 155                 160

 agg ggc tct aag cag atg aat aca ctc cag tgt gct cgt tac gtt tac      764
 Arg Gly Ser Lys Gln Met Asn Thr Leu Gln Cys Ala Arg Tyr Val Tyr
         165                 170                 175

 caa acc gaa ggc att cgt ggc ttc tat aga gga tta act gcc tcg tat      812
 Gln Thr Glu Gly Ile Arg Gly Phe Tyr Arg Gly Leu Thr Ala Ser Tyr
     180                 185                 190

 gct gga att tcc gaa act ata atc tgc ttt gct att tat gaa agt tta      860
 Ala Gly Ile Ser Glu Thr Ile Ile Cys Phe Ala Ile Tyr Glu Ser Leu
 195                 200                 205                 210

 aag aag tat ctg aaa gaa gct cca tta ccc tct tct gca aat ggg act      908
 Lys Lys Tyr Leu Lys Glu Ala Pro Leu Pro Ser Ser Ala Asn Gly Thr
                 215                 220                 225

 gaa aaa aat tcc aca agt ttt ttt gga ctt atg gca gct gct gct ctt      956
 Glu Lys Asn Ser Thr Ser Phe Phe Gly Leu Met Ala Ala Ala Ala Leu
             230                 235                 240

 tct aag ggc tgt gcc tcc tgc att gct tat cca cac gaa gtc ata agg     1004
 Ser Lys Gly Cys Ala Ser Cys Ile Ala Tyr Pro His Glu Val Ile Arg
         245                 250                 255

 acg agg ctc cgg gaa gag ggc acc aag tac aag tct ttt gtc caa acg     1052
 Thr Arg Leu Arg Glu Glu Gly Thr Lys Tyr Lys Ser Phe Val Gln Thr
     260                 265                 270

 gcg cgc ctg gtg ttc cgg gaa gaa ggc tac ctt gcc ttt tat aga gga     1100
 Ala Arg Leu Val Phe Arg Glu Glu Gly Tyr Leu Ala Phe Tyr Arg Gly
 275                 280                 285                 290

 ctg ttt gcc cag ctt atc cgg cag atc cca aat act gcc att gtg ttg     1148
 Leu Phe Ala Gln Leu Ile Arg Gln Ile Pro Asn Thr Ala Ile Val Leu
                 295                 300                 305

 tct act tat gag tta att gtg tac ctg tta gaa gac cgt act cag taa     1196
 Ser Thr Tyr Glu Leu Ile Val Tyr Leu Leu Glu Asp Arg Thr Gln 
             310                 315                 320

 caggccggaa aattgtgctc tagaagaata aaactgaaaa actctagaga attttttttc   1256

 cccattgatg tttagaaagt ttgagactga aacaggaaag gccataaaat atctggttca   1316

 tatcacctgt tggacatttc tttttggatt catgctttct ggaaggttta aattcattaa   1376

 cgttaatagt taattataac ttttttttta acttaagagg attcagggtt aagcaccaac   1436

 taaattaaat catgctattt aatttaaaaa aaaaaaaa                           1474




      <210> 357
      <211> 1167
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (41)..(1117)

      <400> 357
 gagacgacgc tcccagactc ctccggtctc cccgggcagc  atg aag acc gcc gag      55
                                              Met Lys Thr Ala Glu
                                                1               5

 aac atc aga gga acc ggc agc gac ggg ccg cgg aaa cga ggc ctc tgc      103
 Asn Ile Arg Gly Thr Gly Ser Asp Gly Pro Arg Lys Arg Gly Leu Cys
                  10                  15                  20

 gtc ctc tgt ggc ctc ccc gcg gca gga aaa tcg act ttc gcg cgc gcc      151
 Val Leu Cys Gly Leu Pro Ala Ala Gly Lys Ser Thr Phe Ala Arg Ala
              25                  30                  35

 ctc gcc cac cgg ctg cag cag gag cag ggt tgg gcc atc ggt gtt gtc      199
 Leu Ala His Arg Leu Gln Gln Glu Gln Gly Trp Ala Ile Gly Val Val
          40                  45                  50

 gcg tat gat gac gtc atg ccc gac gcg ttt ctc gcc ggg gca aga gcg      247
 Ala Tyr Asp Asp Val Met Pro Asp Ala Phe Leu Ala Gly Ala Arg Ala
      55                  60                  65

 cga ccg gcg cca tcc caa tgg aaa ttg ctt cga cag gaa ctg ttg aag      295
 Arg Pro Ala Pro Ser Gln Trp Lys Leu Leu Arg Gln Glu Leu Leu Lys
  70                  75                  80                  85

 tac ctg gaa tac ttc ttg atg gct gtc att aat ggg tgt cag atg tct      343
 Tyr Leu Glu Tyr Phe Leu Met Ala Val Ile Asn Gly Cys Gln Met Ser
                  90                  95                 100

 gtc cca ccc aac agg act gaa gcc atg tgg gaa gat ttt ata acc tgc      391
 Val Pro Pro Asn Arg Thr Glu Ala Met Trp Glu Asp Phe Ile Thr Cys
             105                 110                 115

 tta aag gat caa gat ctg ata ttt tct gca gca ttt gag gcc cag tct      439
 Leu Lys Asp Gln Asp Leu Ile Phe Ser Ala Ala Phe Glu Ala Gln Ser
         120                 125                 130

 tgc tac ctc tta aca aaa act gct gtt tct aga cct ttg ttt ttg gtt      487
 Cys Tyr Leu Leu Thr Lys Thr Ala Val Ser Arg Pro Leu Phe Leu Val
     135                 140                 145

 ttg gat gac aat ttt tat tat cag agt atg aga tat gaa gtc tac cag      535
 Leu Asp Asp Asn Phe Tyr Tyr Gln Ser Met Arg Tyr Glu Val Tyr Gln
 150                 155                 160                 165

 ctg gct cgg aaa tat tca ttg ggc ttt tgc cag ctc ttt tta gat tgt      583
 Leu Ala Arg Lys Tyr Ser Leu Gly Phe Cys Gln Leu Phe Leu Asp Cys
                 170                 175                 180

 cct ctt gag acc tgt tta cag agg aat ggc cag aga cca cag gca ctg      631
 Pro Leu Glu Thr Cys Leu Gln Arg Asn Gly Gln Arg Pro Gln Ala Leu
             185                 190                 195

 cct cct gag acc atc cac ctg atg cga aga aag cta gaa aag ccc aac      679
 Pro Pro Glu Thr Ile His Leu Met Arg Arg Lys Leu Glu Lys Pro Asn
         200                 205                 210

 cct gag aaa aat gct tgg gaa cac aac agc ctc aca att ccg agt cca      727
 Pro Glu Lys Asn Ala Trp Glu His Asn Ser Leu Thr Ile Pro Ser Pro
     215                 220                 225

 gca tgt gct tcg gag gcc agc ctg gaa gtg act gat tta ttg ctc act      775
 Ala Cys Ala Ser Glu Ala Ser Leu Glu Val Thr Asp Leu Leu Leu Thr
 230                 235                 240                 245

 gct ttg gaa aat cca gta aaa tat gct gag gac aat atg gaa caa aag      823
 Ala Leu Glu Asn Pro Val Lys Tyr Ala Glu Asp Asn Met Glu Gln Lys
                 250                 255                 260

 gac aca gac aga att att tgt tca act aac att ctt cat aaa act gat      871
 Asp Thr Asp Arg Ile Ile Cys Ser Thr Asn Ile Leu His Lys Thr Asp
             265                 270                 275

 cag aca ctc cga agg att gta tct cag aca atg aag gaa gca aaa gat      919
 Gln Thr Leu Arg Arg Ile Val Ser Gln Thr Met Lys Glu Ala Lys Asp
         280                 285                 290

 gaa caa gtg ctt cct cac aac ttg aag ctt cta gca gaa gaa ctt aac      967
 Glu Gln Val Leu Pro His Asn Leu Lys Leu Leu Ala Glu Glu Leu Asn
     295                 300                 305

 cag ctc aaa gca gag ttt ttg gaa gac cta aaa caa gga aac aaa aaa     1015
 Gln Leu Lys Ala Glu Phe Leu Glu Asp Leu Lys Gln Gly Asn Lys Lys
 310                 315                 320                 325

 tat ctg tgc ttt cag caa acc att gac ata cca gat gtc att tct ttt     1063
 Tyr Leu Cys Phe Gln Gln Thr Ile Asp Ile Pro Asp Val Ile Ser Phe
                 330                 335                 340

 ttt cat tat gag aaa gat aat att gta cag aag tat ttt tca aag cag     1111
 Phe His Tyr Glu Lys Asp Asn Ile Val Gln Lys Tyr Phe Ser Lys Gln
             345                 350                 355

 cat taa aatttctgaa ctgccaatca aatgtctcat tttgaaagaa actgaagaga      1167
 His 






      <210> 358
      <211> 2417
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (60)..(2108)

      <400> 358
 aaccttcaag aaacagatgc caagatggga ttagatgtgc aagaaatgta ttggaggaa      59                                                                 
 atg cct atg ggt gat aaa gag gaa gaa gca gaa cat atc tcc tca ttc      107
 Met Pro Met Gly Asp Lys Glu Glu Glu Ala Glu His Ile Ser Ser Phe
   1               5                  10                  15

 ctg gcc act ggt aag aaa ctt tcc ctc cat ttt ggt cat cca cgt gag      155
 Leu Ala Thr Gly Lys Lys Leu Ser Leu His Phe Gly His Pro Arg Glu
              20                  25                  30

 tgt gaa gtc acc agg att gat gac aaa aat aga aga gga ttg gaa gac      203
 Cys Glu Val Thr Arg Ile Asp Asp Lys Asn Arg Arg Gly Leu Glu Asp
          35                  40                  45

 agt gag cca ggt gcc aaa ctc ttc aat aat gat gga gtc tgt tgt tgc      251
 Ser Glu Pro Gly Ala Lys Leu Phe Asn Asn Asp Gly Val Cys Cys Cys
      50                  55                  60

 ctg caa aaa cgg ggg cca gtg aac att aca tca gtg tgt gtg agt ccc      299
 Leu Gln Lys Arg Gly Pro Val Asn Ile Thr Ser Val Cys Val Ser Pro
  65                  70                  75                  80

 agg acc tta caa ata tca gtt ttt gtg tta tca gag aaa tac gag ggt      347
 Arg Thr Leu Gln Ile Ser Val Phe Val Leu Ser Glu Lys Tyr Glu Gly
                  85                  90                  95

 att gtt aaa ttt gaa tcg gat gaa tta cct ttt ggt gta att ggt tct      395
 Ile Val Lys Phe Glu Ser Asp Glu Leu Pro Phe Gly Val Ile Gly Ser
             100                 105                 110

 aat att ggt gat gca cat ttt caa gaa ttc agc cta ggc ccc ggc ccc      443
 Asn Ile Gly Asp Ala His Phe Gln Glu Phe Ser Leu Gly Pro Gly Pro
         115                 120                 125

 ccg ccc cgg ccc cgg ccc cgg cgc ggc cct ggg ggc gga tgc ctg gat      491
 Pro Pro Arg Pro Arg Pro Arg Arg Gly Pro Gly Gly Gly Cys Leu Asp
     130                 135                 140

 gtg gat ttt gcc gtg ggg cca cca ggc tgt tct cac gtg aac agc ttt      539
 Val Asp Phe Ala Val Gly Pro Pro Gly Cys Ser His Val Asn Ser Phe
 145                 150                 155                 160

 aag gtg gga gag aac tgg agg cag gaa ctg cgg gtt atc tac cag tgc      587
 Lys Val Gly Glu Asn Trp Arg Gln Glu Leu Arg Val Ile Tyr Gln Cys
                 165                 170                 175

 ttc gtg tgg tgt gga acc cca gag acc agg aaa agc aag gca aag tcc      635
 Phe Val Trp Cys Gly Thr Pro Glu Thr Arg Lys Ser Lys Ala Lys Ser
             180                 185                 190

 tgc atc tgc cat gtg tgt ggc acc cat ctg aac aga ctc cac tct tgc      683
 Cys Ile Cys His Val Cys Gly Thr His Leu Asn Arg Leu His Ser Cys
         195                 200                 205

 ctt tcc tgt gtc ttc ttt ggc tgc ttc acg gag aaa cac att cac gag      731
 Leu Ser Cys Val Phe Phe Gly Cys Phe Thr Glu Lys His Ile His Glu
     210                 215                 220

 cac gca gag acg aaa caa cac aac tta gca gta gac ctg tat tac gga      779
 His Ala Glu Thr Lys Gln His Asn Leu Ala Val Asp Leu Tyr Tyr Gly
 225                 230                 235                 240

 ggt ata tac tgc ttt atg tgt aag gac tat gta tat gac aaa gac att      827
 Gly Ile Tyr Cys Phe Met Cys Lys Asp Tyr Val Tyr Asp Lys Asp Ile
                 245                 250                 255

 gag caa att gcc aaa gaa gag caa gga gaa gct ttg aaa tta caa gcc      875
 Glu Gln Ile Ala Lys Glu Glu Gln Gly Glu Ala Leu Lys Leu Gln Ala
             260                 265                 270

 tcc acc tca aca gag gtt tct cac cag cag tgt tca gtg cca ggc ctt      923
 Ser Thr Ser Thr Glu Val Ser His Gln Gln Cys Ser Val Pro Gly Leu
         275                 280                 285

 ggt gag aaa ttc cca acc tgg gaa aca acc aaa cca gaa tta gaa ctg      971
 Gly Glu Lys Phe Pro Thr Trp Glu Thr Thr Lys Pro Glu Leu Glu Leu
     290                 295                 300

 ctg ggg cac aac ccg agg aga aga aga atc acc tcc agc ttt acg atc     1019
 Leu Gly His Asn Pro Arg Arg Arg Arg Ile Thr Ser Ser Phe Thr Ile
 305                 310                 315                 320

 ggt tta aga gga ctc atc aat ctt ggc aac acg tgc ttt atg aac tgc     1067
 Gly Leu Arg Gly Leu Ile Asn Leu Gly Asn Thr Cys Phe Met Asn Cys
                 325                 330                 335

 att gtc cag gcc ctc acc cac acg ccg ata ctg aga gat ttc ttt ctc     1115
 Ile Val Gln Ala Leu Thr His Thr Pro Ile Leu Arg Asp Phe Phe Leu
             340                 345                 350

 tct gac agg cac cga tgt gag atg ccg agt ccc gag ttg tgt ctg gtc     1163
 Ser Asp Arg His Arg Cys Glu Met Pro Ser Pro Glu Leu Cys Leu Val
         355                 360                 365

 tgt gag atg tcg tcg ctg ttt cgg gag ttg tat tct gga aac ccg tct     1211
 Cys Glu Met Ser Ser Leu Phe Arg Glu Leu Tyr Ser Gly Asn Pro Ser
     370                 375                 380

 cct cat gtg ccc tat aag tta ctg cac ctg gtg tgg ata cat gcc cgc     1259
 Pro His Val Pro Tyr Lys Leu Leu His Leu Val Trp Ile His Ala Arg
 385                 390                 395                 400

 cat tta gca ggg tac agg caa cag gat gcc cac gag ttc ctc att gca     1307
 His Leu Ala Gly Tyr Arg Gln Gln Asp Ala His Glu Phe Leu Ile Ala
                 405                 410                 415

 gcg tta gat gtc ctg cac agg cac tgc aaa ggt gat gat gtc ggg aag     1355
 Ala Leu Asp Val Leu His Arg His Cys Lys Gly Asp Asp Val Gly Lys
             420                 425                 430

 gcg gcc aac aat ccc aac cac tgt aac tgc atc ata gac caa atc ttc     1403
 Ala Ala Asn Asn Pro Asn His Cys Asn Cys Ile Ile Asp Gln Ile Phe
         435                 440                 445

 aca ggt ggc ctg cag tct gat gtc acc tgt caa gcc tgc cat ggc gtc     1451
 Thr Gly Gly Leu Gln Ser Asp Val Thr Cys Gln Ala Cys His Gly Val
     450                 455                 460

 tcc acc acg ata gac cca tgc tgg gac att agt ttg gac ttg cct ggc     1499
 Ser Thr Thr Ile Asp Pro Cys Trp Asp Ile Ser Leu Asp Leu Pro Gly
 465                 470                 475                 480

 tct tgc acc tcc ttc tgg ccc atg agc cca ggg agg gag agc agt gtg     1547
 Ser Cys Thr Ser Phe Trp Pro Met Ser Pro Gly Arg Glu Ser Ser Val
                 485                 490                 495

 aac ggg gaa agc cac ata cca gga atc acc acc ctc acg gac tgc ttg     1595
 Asn Gly Glu Ser His Ile Pro Gly Ile Thr Thr Leu Thr Asp Cys Leu
             500                 505                 510

 cgg agg ttt acg agg cca gag cac tta gga agc agt gcc aaa atc aaa     1643
 Arg Arg Phe Thr Arg Pro Glu His Leu Gly Ser Ser Ala Lys Ile Lys
         515                 520                 525

 tgt ggt agt tgc caa agc tac cag gaa tct acc aaa cag ctc aca atg     1691
 Cys Gly Ser Cys Gln Ser Tyr Gln Glu Ser Thr Lys Gln Leu Thr Met
     530                 535                 540

 aat aaa tta cct gtc gtt gcc tgt ttt cat ttc aaa cgg ttt gaa cat     1739
 Asn Lys Leu Pro Val Val Ala Cys Phe His Phe Lys Arg Phe Glu His
 545                 550                 555                 560

 tca gcg aaa cag agg cgc aag atc act aca tac att tcc ttt cct ctg     1787
 Ser Ala Lys Gln Arg Arg Lys Ile Thr Thr Tyr Ile Ser Phe Pro Leu
                 565                 570                 575

 gag ctg gat atg acg ccg ttt atg gcc tca agt aaa gag agc aga atg     1835
 Glu Leu Asp Met Thr Pro Phe Met Ala Ser Ser Lys Glu Ser Arg Met
             580                 585                 590

 aat gga caa ttg cag ctg cca acc aat agt gga aac aac gaa aat aag     1883
 Asn Gly Gln Leu Gln Leu Pro Thr Asn Ser Gly Asn Asn Glu Asn Lys
         595                 600                 605

 tat tcc ttg ttt gct gtg gtt aat cac caa gga acc ttg gag agt ggc     1931
 Tyr Ser Leu Phe Ala Val Val Asn His Gln Gly Thr Leu Glu Ser Gly
     610                 615                 620

 cac tat acc agc ttc atc cgg cac cac aag gac cag tgg ttc aag tgt     1979
 His Tyr Thr Ser Phe Ile Arg His His Lys Asp Gln Trp Phe Lys Cys
 625                 630                 635                 640

 gat gat gcc gtc atc act aag gcc agt att aag gac gta ctg gac agt     2027
 Asp Asp Ala Val Ile Thr Lys Ala Ser Ile Lys Asp Val Leu Asp Ser
                 645                 650                 655

 gaa ggg tat tta ctg ttc tat cac aaa cag gtg cta gat cat gag tca     2075
 Glu Gly Tyr Leu Leu Phe Tyr His Lys Gln Val Leu Asp His Glu Ser
             660                 665                 670

 gaa aaa gtg aaa gaa atg aac act caa gcc tag tatagtta cacacagacc     2126
 Glu Lys Val Lys Glu Met Asn Thr Gln Ala 
         675                 680

 taccttcaat ggaagatgac gacaccaata ttacaactgg catcgagatc taaaggacct   2186

 acttgaccat ggcccatggg cctgacagag taagaattga acagtaccca gtgtccaaaa   2246

 ggtcctgatt ggaagagaaa tagaagggga gggagaagag gctctagtct aagcagttga   2306

 tgaaagggaa attaaatggt agaaacactc tgggtgagga aggcaggagc aggaaaatgc   2366

 tgacactggt acatatccta tattcctcca aaagattgtg tagaaattga a            2417




      <210> 359
      <211> 2372
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (138)..(719)

      <400> 359
 tttcgtccga aaggtctggt cgcagagaca ggaacgtgta atcctcagcg tgctccagcc     60

 cacagcttcg ctctactgct cggcagggca gctggcctct gggcaccggc ggcccctctg    120

 cctcgcggaa aagcctg   atg aag tcc tcc gat att gat cag gat tta ttc     170
                      Met Lys Ser Ser Asp Ile Asp Gln Asp Leu Phe
                        1               5                  10

 aca gac agt tac tgc aag gtg tgc agt gca cag ctg atc tcc gaa tcg      218
 Thr Asp Ser Tyr Cys Lys Val Cys Ser Ala Gln Leu Ile Ser Glu Ser
              15                  20                  25

 cag cgt gtg gcc cac tac gag agt cga aaa cat gca agc aaa gtc cga      266
 Gln Arg Val Ala His Tyr Glu Ser Arg Lys His Ala Ser Lys Val Arg
          30                  35                  40

 ctg tat tac atg ctt cac ccc agg gat gga ggg tgt cct gcc aag agg      314
 Leu Tyr Tyr Met Leu His Pro Arg Asp Gly Gly Cys Pro Ala Lys Arg
      45                  50                  55

 ctc cgg tca gaa aat gga agt gat gcc gac atg gtg gat aag aac aag      362
 Leu Arg Ser Glu Asn Gly Ser Asp Ala Asp Met Val Asp Lys Asn Lys
  60                  65                  70                  75

 tgc tgc aca ctc tgc aac atg tca ttc act tca gcg gtg gtg gcc gat      410
 Cys Cys Thr Leu Cys Asn Met Ser Phe Thr Ser Ala Val Val Ala Asp
                  80                  85                  90

 tcc cat tat caa ggc aaa atc cac gcc aag agg tta aaa ctc ttg cta      458
 Ser His Tyr Gln Gly Lys Ile His Ala Lys Arg Leu Lys Leu Leu Leu
              95                 100                 105

 gga gag aag acc cca tta aag acc aca gca aca ccc ctg agc cca ctt      506
 Gly Glu Lys Thr Pro Leu Lys Thr Thr Ala Thr Pro Leu Ser Pro Leu
         110                 115                 120

 aag ccc cca cgg atg gac act gct ccg gtg gtc gca tct ccc tat caa      554
 Lys Pro Pro Arg Met Asp Thr Ala Pro Val Val Ala Ser Pro Tyr Gln
     125                 130                 135

 aga aga gat tca gac aga tac tgt ggg ctc tgt gca gcc tgg ttt aat      602
 Arg Arg Asp Ser Asp Arg Tyr Cys Gly Leu Cys Ala Ala Trp Phe Asn
 140                 145                 150                 155

 aac cct ctg atg gcc cag caa cat tat gat ggc aag aaa cac aaa aag      650
 Asn Pro Leu Met Ala Gln Gln His Tyr Asp Gly Lys Lys His Lys Lys
                 160                 165                 170

 aat gcg gca aga gtt gct ttg tta gaa caa ctg ggg aca acc ctg gat      698
 Asn Ala Ala Arg Val Ala Leu Leu Glu Gln Leu Gly Thr Thr Leu Asp
             175                 180                 185

 atg ggg gaa ctg aga gcc tga ag aataagtagt gaaagcatca atcaagacat      751
 Met Gly Glu Leu Arg Ala 
         190

 aagaacaaaa cattagcatt tctctgccgt ggagaattgc ttatcaacca ccagaggagg    811

 cttctttctt gaacaataaa catttcttat aaggattcac agattcacat acgactgatc    871

 ttgatttttg gaaatgaatg aggtttcttt tttctttttc ctttttttta attttggggt    931

 aagttatgat atttggatgg atttttaaat tctttcctga taacatattt agcacatgtt    991

 ctaaattata atcctatagc aaacagttgg agcattattc aaactgaaag tggaaaaatt   1051

 taaatttcca atttattcta gatttcctca gagcataatt attctgttaa atcctcaatg   1111

 agtgtgatgt aaaccacctc tatccagaaa tatacattct tttctcatca tgttggacac   1171

 agttgagggt gacatgcaca gaactggaac agatcactat tagtggaaaa taccaaatgg   1231

 acaaataaat accagtcgtt ttctccgttc tccaagcaca ggagccaggt ttaccatctg   1291

 aacaatgaag acgaagggag taaataaagg aagaattctc atcttttttc ctgatcattc   1351

 aaagaacagt ttctcaaggt taagccaagt cctccttgca agttgccaaa taatagctta   1411

 ggaaaagaat tagtctgcct gcatgatgat cttcttaggc aaaaacgtct tcacagccct   1471

 tgaccttggt gaattttttt ccccaaaagc atccaaaaga agaattataa accccagaat   1531

 gagatggaaa taaacaagta ttttttttta tgatgtttgg cctgaactgt gggctttaat   1591

 tgggggatac tgatcgtttg gaaagaagtg agaaaattct gaagaaatgg cggccttggg   1651

 ctaggcgggg tcccctattt cttctgtttc tcactgaagt cctactgctg agccaagact   1711

 cagtcactct ggaaagagca tgaccgataa agaaaacagt tcctttctga tggggagcgt   1771

 ctgagtgcag atcatgaggc tctttctcta ggtttaattc ttttccatgg tgaccggact   1831

 tggtgtcttg tagcctggtt acgaagtggg acgttgagct tctactgacg atgccctgca   1891

 tggaccagct gggatctggc tggggctgcc ctgtgtccct aacgaccata ggcaatccat   1951

 cttcttgtgt cagcaatttc tggacaccca ctgttttcca ccaagagctg aggtggcaac   2011

 aactcagtga gcaataaaca aaatgacaca gaaatgcaca gtgttgttat gaaggagcct   2071

 gtttacctgt gttcaaaatc tggcaccatt cccttgagca gggcccgctc aggagggacc   2131

 aggtctgcca gtttctgtgc ctgcagagag acgaagcccc acgagccaca ccctactcta   2191

 caagaggaaa gggggttgga tgggaagaat ctattttgct gttttggaaa gcacacagcc   2251

 gacctacaaa cctcctgtga tggtgtttct tcggatgtgt aaaataaggc tttatttgtc   2311

 aattccgctg taaaataagc attgtccgag taaaaacagc agcaacaaca aaaaaaaaaa   2371

 a                                                                   2372




      <210> 360
      <211> 1206
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (99)..(755)

      <220>
      <221> misc_feature
      <222> (1)...(1206)
      <223> n = a,t,c or g

      <400> 360
 cgagaaagaa ctccggaaac tatcaatcaa tacaaggctg ccgttcggcg gcctttttta     60

 ttcctagcaa cagcactcgc acaaagcgag gtgagagt    atg tat cgc atg gac     113
                                              Met Tyr Arg Met Asp
                                                1               5

 aaa cta acc act ggt gct gcc tat ggc gct tca gcc ggg agc atc cta      161
 Lys Leu Thr Thr Gly Ala Ala Tyr Gly Ala Ser Ala Gly Ser Ile Leu
                  10                  15                  20

 aac ggc atg ttg aat gcc tac agc ccc gag cag tgg aac gct atc ggc      209
 Asn Gly Met Leu Asn Ala Tyr Ser Pro Glu Gln Trp Asn Ala Ile Gly
              25                  30                  35

 gtg ctg aca acc gcc gca gca gga gcc gag atg aac cca acg ttg agg      257
 Val Leu Thr Thr Ala Ala Ala Gly Ala Glu Met Asn Pro Thr Leu Arg
          40                  45                  50

 aat aag ctg gtg ggt gcc att gtt ggc gga tca ggg gca atc act att      305
 Asn Lys Leu Val Gly Ala Ile Val Gly Gly Ser Gly Ala Ile Thr Ile
      55                  60                  65

 gct gca gta atg ctg ggc aat gcg gat gga ctc gaa ggt cgg cgt tat      353
 Ala Ala Val Met Leu Gly Asn Ala Asp Gly Leu Glu Gly Arg Arg Tyr
  70                  75                  80                  85

 tac gcc tat cag gat gtg gtc ggc gtc tgg acc gtt tgc gat ggg cac      401
 Tyr Ala Tyr Gln Asp Val Val Gly Val Trp Thr Val Cys Asp Gly His
                  90                  95                 100

 act ggt acc gac att cgc cgc ggt cac cga tat acc gac aaa gag tgt      449
 Thr Gly Thr Asp Ile Arg Arg Gly His Arg Tyr Thr Asp Lys Glu Cys
             105                 110                 115

 gac aac ctg ctt aag gca gat ctg cga aag gtg gca agc gcc atc gac      497
 Asp Asn Leu Leu Lys Ala Asp Leu Arg Lys Val Ala Ser Ala Ile Asp
         120                 125                 130

 ccg ctg atc aag gtt cgc atc cct gag cca acc cgc gcc gcg ctt tac      545
 Pro Leu Ile Lys Val Arg Ile Pro Glu Pro Thr Arg Ala Ala Leu Tyr
     135                 140                 145

 tcc ttc acc tat aac gac aga gat cat gga agt tgg gcc cga ctg gat      593
 Ser Phe Thr Tyr Asn Asp Arg Asp His Gly Ser Trp Ala Arg Leu Asp
 150                 155                 160                 165

 gag att tgg ggg tct ttg gaa gtg gag aat gtg ttt gcc ctg ggg aag      641
 Glu Ile Trp Gly Ser Leu Glu Val Glu Asn Val Phe Ala Leu Gly Lys
                 170                 175                 180

 aga gca tct tgt aag gag cag gtg gag cat atg gac aag cca tcc cca      689
 Arg Ala Ser Cys Lys Glu Gln Val Glu His Met Asp Lys Pro Ser Pro
             185                 190                 195

 cca gcc cct gag aca tgt gag aga ggc cag aac agg cca tcc gga ccc      737
 Pro Ala Pro Glu Thr Cys Glu Arg Gly Gln Asn Arg Pro Ser Gly Pro
         200                 205                 210

 cac tgt gct ggt gga tga gacagc agaaggaata tcaacctacc aacagaatcc      791
 His Cys Ala Gly Gly 
     215

 tgagaaatgc tcactcttac ttcaagctgc tgcattttga tgttatgaaa ccataaataa    851

 cttatgaagt catctttgct gacttaaagt tttccataac tttattataa catatcaaaa    911

 ttatgaaaaa tgtgaaaagt agaaaactga tgaattttgc ttcttcatat ggtctttaag    971

 aatctcaaag gcactgaagt tttttatctt ttctgtctta gaataaaaaa ccttgaatga   1031

 aaatctgctt cttggaaaag cagcaaggtt tatgcagagg caatctggta tttgtgtgca   1091

 ctggcagctg atcataccca gcatgcacgc actctcaggg cagagtctga tgccccacat   1151

 aatggngcat ggtaaggact cccatgtcct tgagatnaaa atgataggaa natac        1206




      <210> 361
      <211> 1727
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (327)..(1727)

      <400> 361
 tttcgtgaga acgcgagccg ggagtccgtg gaggccatgg cccctcggcg cctcctgttg     60

 gttggggagg ggaatttctc cttcgccgcc gctctgagcg aaaccctgga tcagagcact    120

 caacttaccg ccacctgcct ccagcgcccg gccgagttgg ctcgggatcc actggcctgg    180

 gagaatctgc agtgcctgcg cgagcgagct gtgcagacgt tcttgcagag gaaggagaag    240

 tccacgtggc attatgtaga ggacaaggtg gaactcctgc ggataagccc cagagagaat    300

 ggcacaacag ttggcaagtg gttgcc atg gca gcc ctg ggg ggg ctc att tta     353
                              Met Ala Ala Leu Gly Gly Leu Ile Leu
                                1               5

 agc gac gtg tat cca ttc agc tgt aag gct gtg gca ggg tac aag tgc      401
 Ser Asp Val Tyr Pro Phe Ser Cys Lys Ala Val Ala Gly Tyr Lys Cys
  10                  15                  20                  25

 act gga tat agg ggt ttc ctg gaa gca cct tca tgt cat cct atc aaa      449
 Thr Gly Tyr Arg Gly Phe Leu Glu Ala Pro Ser Cys His Pro Ile Lys
                  30                  35                  40

 acc ata aat gag aaa ctc att gct gaa tta ggc aaa gtt ttc ccg cta      497
 Thr Ile Asn Glu Lys Leu Ile Ala Glu Leu Gly Lys Val Phe Pro Leu
              45                  50                  55

 aaa agg ctg aag tgt tcc tac cct ttg ctg cca cag gaa ggt acc agt      545
 Lys Arg Leu Lys Cys Ser Tyr Pro Leu Leu Pro Gln Glu Gly Thr Ser
          60                  65                  70

 gtt ctt cct ttc tgg aat tgt gac ttt ctg tca gct gct ttt tgg att      593
 Val Leu Pro Phe Trp Asn Cys Asp Phe Leu Ser Ala Ala Phe Trp Ile
      75                  80                  85

 agt ctc cat gaa gat aac tca aat tct gag tcc ctg act ggt ggg aca      641
 Ser Leu His Glu Asp Asn Ser Asn Ser Glu Ser Leu Thr Gly Gly Thr
  90                  95                 100                 105

 tca caa gat gtg gaa gac ttt cta gtg tca ttt tca gaa ctt agc ctt      689
 Ser Gln Asp Val Glu Asp Phe Leu Val Ser Phe Ser Glu Leu Ser Leu
                 110                 115                 120

 ctc aag aat cct gga aga gat ggt aaa gaa gaa gct tgt gaa gga acc      737
 Leu Lys Asn Pro Gly Arg Asp Gly Lys Glu Glu Ala Cys Glu Gly Thr
             125                 130                 135

 tgt ggc cag gcc aag atc tgc ctt aga cct tct ctc cta gtg cat gtt      785
 Cys Gly Gln Ala Lys Ile Cys Leu Arg Pro Ser Leu Leu Val His Val
         140                 145                 150

 cag gat gtc atc gaa gta cca gac ttc ctc tca ggt tct ctg cac atc      833
 Gln Asp Val Ile Glu Val Pro Asp Phe Leu Ser Gly Ser Leu His Ile
     155                 160                 165

 ctc agt gga cct gtc ttt cag aag tgc cac att ttg cct ttc aca atg      881
 Leu Ser Gly Pro Val Phe Gln Lys Cys His Ile Leu Pro Phe Thr Met
 170                 175                 180                 185

 cca gca ttt cat gaa act tta ttt atc ctt ggg gtt aat caa aat ctg      929
 Pro Ala Phe His Glu Thr Leu Phe Ile Leu Gly Val Asn Gln Asn Leu
                 190                 195                 200

 aag gat ggc tgt ctt caa tca ctg ctg gat cat ctg aag ggc att cta      977
 Lys Asp Gly Cys Leu Gln Ser Leu Leu Asp His Leu Lys Gly Ile Leu
             205                 210                 215

 gat agc ctg ctg acc cag aca ttg ccg gag agc tct aag ctg agc agt     1025
 Asp Ser Leu Leu Thr Gln Thr Leu Pro Glu Ser Ser Lys Leu Ser Ser
         220                 225                 230

 tta gtc aaa ttt gtc ctt cag tca aat gga aag gat tat atg att cgt     1073
 Leu Val Lys Phe Val Leu Gln Ser Asn Gly Lys Asp Tyr Met Ile Arg
     235                 240                 245

 gtg aag act cat aat ttt agc cca gat tgt act gag gat cta att att     1121
 Val Lys Thr His Asn Phe Ser Pro Asp Cys Thr Glu Asp Leu Ile Ile
 250                 255                 260                 265

 ggg tct gtt atc aca tct gcc act agt gtt ata cat aaa gac cag tgt     1169
 Gly Ser Val Ile Thr Ser Ala Thr Ser Val Ile His Lys Asp Gln Cys
                 270                 275                 280

 ttt gtg ttt gtg tct atg aac ttg gac tta tta gcc atg ctt gtc tgg     1217
 Phe Val Phe Val Ser Met Asn Leu Asp Leu Leu Ala Met Leu Val Trp
             285                 290                 295

 tgt atc tct gac tgg aga atg ttg tgg acg ttt gat aac cgt ttc ctg     1265
 Cys Ile Ser Asp Trp Arg Met Leu Trp Thr Phe Asp Asn Arg Phe Leu
         300                 305                 310

 aaa aat ttt gtc cct ggc aaa ata gaa ccc ttt aaa agt cat tct ctg     1313
 Lys Asn Phe Val Pro Gly Lys Ile Glu Pro Phe Lys Ser His Ser Leu
     315                 320                 325

 tat cct cca tgt tat gtg cat gat gtt agt ttt tgg ata gat cag aag     1361
 Tyr Pro Pro Cys Tyr Val His Asp Val Ser Phe Trp Ile Asp Gln Lys
 330                 335                 340                 345

 aaa gga ttt gat gaa cta gag ttt cac act gtg gcc cga gca gtg tct     1409
 Lys Gly Phe Asp Glu Leu Glu Phe His Thr Val Ala Arg Ala Val Ser
                 350                 355                 360

 cag gac act att ata tcc ata cag ttt ctt agc cgt ttc cag cat cca     1457
 Gln Asp Thr Ile Ile Ser Ile Gln Phe Leu Ser Arg Phe Gln His Pro
             365                 370                 375

 aag act caa cag gtc agt ctc tgc tat aga ttg acc tac cag acc tgt     1505
 Lys Thr Gln Gln Val Ser Leu Cys Tyr Arg Leu Thr Tyr Gln Thr Cys
         380                 385                 390

 gac aag gcc ctc acc cag cag caa gta gca tca atg cag tcc cag ttt     1553
 Asp Lys Ala Leu Thr Gln Gln Gln Val Ala Ser Met Gln Ser Gln Phe
     395                 400                 405

 agg aag gag att caa caa cac cta tat gtt ata cct cgt agt gct tgg     1601
 Arg Lys Glu Ile Gln Gln His Leu Tyr Val Ile Pro Arg Ser Ala Trp
 410                 415                 420                 425

 tac atg tat aag gta gcg ttt gaa agc tgg atc tta aaa caa ggg cag     1649
 Tyr Met Tyr Lys Val Ala Phe Glu Ser Trp Ile Leu Lys Gln Gly Gln
                 430                 435                 440

 gaa tgt gaa ggg aga att gtt agg caa gta ggg tgt gca ttt tgg gca     1697
 Glu Cys Glu Gly Arg Ile Val Arg Gln Val Gly Cys Ala Phe Trp Ala
             445                 450                 455

 gag gac atc cat aaa cag aga tat aga taa                             1727
 Glu Asp Ile His Lys Gln Arg Tyr Arg 
         460                 465





      <210> 362
      <211> 1631
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (581)..(1192)

      <220>
      <221> misc_feature
      <222> (1)...(1631)
      <223> n = a,t,c or g

      <400> 362
 gttggaattc gcagaacttt tggaagagct gagtacaaca cactgcgaaa ctacactcac     60

 agaagggaaa aaacagagag aaacattgaa agtggctgga aacagatttc cgcactgtct    120

 cgttccacgc gctcacgccg atggagccag gggccccccg accggacacg ccaaggctca    180

 cgggatctcc ctgtcttctc gtgtgaaccc gccccagttg tcgcaatgcc tggagacctg    240

 gacgtcctgc ctatgaagga cgaggatgtg ctcaagttcc ttgcggtagg agcccacgca    300

 ggcggcacca cccttggctt ccagatggag cagtgtatcc actaaaggac ggaccagcga    360

 tggcatctnt gtcataaatc tgaagggacc tgggagaagc tgctgctggc agctcgtgcc    420

 attgttgctg ttgaaccctg ctgaggtccc tgtcttgctc caggaacact ggccggcagg    480

 ctgtgctgaa gctcactgct gccaccagag ccactccagc tgctggccgc ttctctcctg    540

 gaaccttcac tcgccagacc caggcagcct tccgggagcc  atg tct gct ggt ccc     595
                                              Met Ser Ala Gly Pro
                                                1               5

 agg cga cca cca gcc tct cag aga ggc gtc ttg gct agc cca cct ccc      643
 Arg Arg Pro Pro Ala Ser Gln Arg Gly Val Leu Ala Ser Pro Pro Pro
                  10                  15                  20

 att gct ctg tgg aac aca gat tct cct ctg tgc tgt gtg gaa gtc gcc      691
 Ile Ala Leu Trp Asn Thr Asp Ser Pro Leu Cys Cys Val Glu Val Ala
              25                  30                  35

 atc ccg tgc aac aag gga gct cac tca gtg ggc ctg aag ggg tgg ctg      739
 Ile Pro Cys Asn Lys Gly Ala His Ser Val Gly Leu Lys Gly Trp Leu
          40                  45                  50

 ctg gct cag gga gtt ctg ggc atg cgt gac acc atc ccc cag gaa cac      787
 Leu Ala Gln Gly Val Leu Gly Met Arg Asp Thr Ile Pro Gln Glu His
      55                  60                  65

 cca tgg gag tcc acg cct gac ctc tgc ttc tgc aga gac cct gaa gag      835
 Pro Trp Glu Ser Thr Pro Asp Leu Cys Phe Cys Arg Asp Pro Glu Glu
  70                  75                  80                  85

 att gag gtg gaa gag cag cct gct gct gat gca gct gtg gcc aag ggg      883
 Ile Glu Val Glu Glu Gln Pro Ala Ala Asp Ala Ala Val Ala Lys Gly
                  90                  95                 100

 gag ttt cag ggg aac aga ttg ctc cag tgc ctg ctg agc att gcc gcc      931
 Glu Phe Gln Gly Asn Arg Leu Leu Gln Cys Leu Leu Ser Ile Ala Ala
             105                 110                 115

 cag cct gag gct gca gac cca gcc cct gtg cat act acc gct cag ccc      979
 Gln Pro Glu Ala Ala Asp Pro Ala Pro Val His Thr Thr Ala Gln Pro
         120                 125                 130

 aag ggt gca gac cca gcc cct gca cac act gcc gcc cag gtt gag ggt     1027
 Lys Gly Ala Asp Pro Ala Pro Ala His Thr Ala Ala Gln Val Glu Gly
     135                 140                 145

 gga gac cca gcc cct gca cgc act gct gct cag cct gag gct gca gac     1075
 Gly Asp Pro Ala Pro Ala Arg Thr Ala Ala Gln Pro Glu Ala Ala Asp
 150                 155                 160                 165

 tgc tct gaa ggt gca ggt acc ccc tgt gcc tat tca gcc gtc cct act     1123
 Cys Ser Glu Gly Ala Gly Thr Pro Cys Ala Tyr Ser Ala Val Pro Thr
                 170                 175                 180

 gca gac tgg agc act cag cct gcc agg caa gcc tgt tct gca gct ccc     1171
 Ala Asp Trp Ser Thr Gln Pro Ala Arg Gln Ala Cys Ser Ala Ala Pro
             185                 190                 195

 aat gct cag gcc cct gaa tga gg aggatcaacc actgagcggt ctcaagctgt     1224
 Asn Ala Gln Ala Pro Glu 
         200

 tcttccacag gccaccagca agatggaaat aaggccgatg gaaaataaac atcagtttct   1284

 atttaaaaca atgatattcg ggtctgtttg caatgtgatt atttcatgaa gtttaacaga   1344

 attaccacat ggcactgctc tgagatgtga agctgttttc tacattttgg gagattaaaa   1404

 aaatgctttc ccctaatatt tcgagctagt ttgaaaatta taaatgttct cctttctttc   1464

 caccaaagtg ataaaagaac caatgagtat acattgggct tactcagcat ttattggttg   1524

 tagttgaggc gttttgagga aatacaaagg tgaatcctag tgatacaaaa cccgtgacac   1584

 agggtcaggt gcaatacatt ttgtgagggt cgcgcaaaaa aaaaaaa                 1631




      <210> 363
      <211> 2061
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (97)..(1206)

      <400> 363
 caacccggct gcattaaatc ctgcctcatt gcagtgtaag ttggacgaaa aggatatacc     60

 attctcagct acagacatca agacaagtac tgccag  atg cca tcc ttt gaa gaa     114
                                          Met Pro Ser Phe Glu Glu
                                            1               5

 ata tgt gtt ttc agt aga act ctt ttc att gtt ctg ttt ttc ttg cct      162
 Ile Cys Val Phe Ser Arg Thr Leu Phe Ile Val Leu Phe Phe Leu Pro
              10                  15                  20

 tcg gat gtt act caa aat agt gaa caa cct gcc cca gaa gaa tat gat      210
 Ser Asp Val Thr Gln Asn Ser Glu Gln Pro Ala Pro Glu Glu Tyr Asp
          25                  30                  35

 caa tta caa ttt gtg ctt caa gaa gag ttt tcc agt gat gat tca aca      258
 Gln Leu Gln Phe Val Leu Gln Glu Glu Phe Ser Ser Asp Asp Ser Thr
      40                  45                  50

 aca aat gca caa tct gtt atc ttt gga ggc tat gct ttc ttc aag tta      306
 Thr Asn Ala Gln Ser Val Ile Phe Gly Gly Tyr Ala Phe Phe Lys Leu
  55                  60                  65                  70

 aca ctc tct agg agt cct tta gtc tcc caa cca ggt aat aaa ggt aga      354
 Thr Leu Ser Arg Ser Pro Leu Val Ser Gln Pro Gly Asn Lys Gly Arg
                  75                  80                  85

 gaa ttt gtg cca gat gaa caa aag caa agt atc ctt cca tct ccc aaa      402
 Glu Phe Val Pro Asp Glu Gln Lys Gln Ser Ile Leu Pro Ser Pro Lys
              90                  95                 100

 ttt tca gag gaa gaa att gaa cct ttg cct ccc aca cta gag aaa aag      450
 Phe Ser Glu Glu Glu Ile Glu Pro Leu Pro Pro Thr Leu Glu Lys Lys
         105                 110                 115

 ccc tca gaa aat atg tcc att cag cta gac tct aca ttt aaa caa atg      498
 Pro Ser Glu Asn Met Ser Ile Gln Leu Asp Ser Thr Phe Lys Gln Met
     120                 125                 130

 aaa gat gaa gat cta caa tct gct att gta caa cct tct caa atg caa      546
 Lys Asp Glu Asp Leu Gln Ser Ala Ile Val Gln Pro Ser Gln Met Gln
 135                 140                 145                 150

 acc aag ctt ctg cag gac caa gct gcg tca ctc caa gtt ttt cca tcc      594
 Thr Lys Leu Leu Gln Asp Gln Ala Ala Ser Leu Gln Val Phe Pro Ser
                 155                 160                 165

 cat tct gca cta aaa ctc gaa gat ata tca cct gaa gac ttg cca tcc      642
 His Ser Ala Leu Lys Leu Glu Asp Ile Ser Pro Glu Asp Leu Pro Ser
             170                 175                 180

 caa gct cta cca gta gaa ggc ctg tca gaa caa acc atg cca tct aag      690
 Gln Ala Leu Pro Val Glu Gly Leu Ser Glu Gln Thr Met Pro Ser Lys
         185                 190                 195

 tct aca tca tcc cat gtc aaa cag tct tct aat ctg aca gct aat gac      738
 Ser Thr Ser Ser His Val Lys Gln Ser Ser Asn Leu Thr Ala Asn Asp
     200                 205                 210

 ctg ccc cct caa ggc ata cta tcc caa gac aca tca tct caa gat atg      786
 Leu Pro Pro Gln Gly Ile Leu Ser Gln Asp Thr Ser Ser Gln Asp Met
 215                 220                 225                 230

 ctg ttt cat gac atg aca tcc caa gat atg caa tcc cta gat atg cta      834
 Leu Phe His Asp Met Thr Ser Gln Asp Met Gln Ser Leu Asp Met Leu
                 235                 240                 245

 tct caa gac aca cca tcc cac gcc atg cca cct caa gac ata cct tcc      882
 Ser Gln Asp Thr Pro Ser His Ala Met Pro Pro Gln Asp Ile Pro Ser
             250                 255                 260

 caa gat atg cta tcc caa gct cta tca gcg cat gcc ata tta cct gaa      930
 Gln Asp Met Leu Ser Gln Ala Leu Ser Ala His Ala Ile Leu Pro Glu
         265                 270                 275

 gcc tca aca tcc cat att gtg cag ttc cct gaa ata caa cac cta ctt      978
 Ala Ser Thr Ser His Ile Val Gln Phe Pro Glu Ile Gln His Leu Leu
     280                 285                 290

 cag cag ccc cca gat ctt caa cca gaa aac act gaa cct caa aac cag     1026
 Gln Gln Pro Pro Asp Leu Gln Pro Glu Asn Thr Glu Pro Gln Asn Gln
 295                 300                 305                 310

 caa att tta caa atg tca tat caa gat att aga tca gaa gtt atg gaa     1074
 Gln Ile Leu Gln Met Ser Tyr Gln Asp Ile Arg Ser Glu Val Met Glu
                 315                 320                 325

 gag acc aaa gaa tgg aaa tct gag gag gaa ctc cat aga aga aaa tcc     1122
 Glu Thr Lys Glu Trp Lys Ser Glu Glu Glu Leu His Arg Arg Lys Ser
             330                 335                 340

 tca aga cgg cat tcc tta aac cag caa acc aaa gcc ttg caa tac tta     1170
 Ser Arg Arg His Ser Leu Asn Gln Gln Thr Lys Ala Leu Gln Tyr Leu
         345                 350                 355

 agg aga cat tct tta gac gtg caa gcc aaa ggc tag aaat cctcaaagag     1220
 Arg Arg His Ser Leu Asp Val Gln Ala Lys Gly 
     360                 365

 gcattcctta gatcagcaaa gcaaaggctg gcaatctcca aagcagaaat ccttagacca   1280

 gcaaatcaaa gactggctat ccccaaagag gcactccgta gataagcaag ctcaacttaa   1340

 tcaaactaaa gagcaactcc cagatcagca agctgaagat cagcaagcca aaggggaaca   1400

 atacccagaa ggacaatcta aagatggaca agttaaagac cagcagactg ataaggagca   1460

 aaactcaaag aagcaaaccc aggatcagca aactgaagac cagccggccc aagagaagaa   1520

 atccccgaaa ggacaattcc aaaatgttca agccgaagga cagcaagctc agggctggag   1580

 aaacaaagat tataaagcac gagaatggca atttgaaatg aagcactggc aaacacagga   1640

 tctattagag aaagaagccc taaagcagaa agctctatac caagaagtcc aaacccagca   1700

 cgcaacagcc caacataacc tagaatgtca agacactcaa gataaagacc aacaagacct   1760

 tcaatccaga gttacacaaa aaggagatat gtacactaga gacatcaaac caggggacat   1820

 gaaatgtata gggcaaacct caggggacct gcaatcagaa gacgtgaagg cagattttca   1880

 ttcttcttct ggccaaagct cagtacaaga cacatgttta gcctatttgt ccaatctaga   1940

 ttcagaacaa gatgtgcaac cagacacttc agcttcctca aattcatata aagaagatgt   2000

 gaatttaact tctacttcat gtgatccaaa agatcaacag caatctgaag actctgacta   2060

 a                                                                   2061




      <210> 364
      <211> 2082
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(1967)

      <400> 364
 tttcgtccga ctcccccctg ttgccttatt accttccgac cacctctcgg acctcttgcc     60

 cagcccttcc ccgtagacat caccccagat acggtggtga caccattgct atgggcccac    120

 gtagggcgca gtgcgagcca gggcaggacg cacttggtac gacccacgcc gcgccccgcg    180

 ccgccggaag tgaggtgtct gacccccgaa gttccggttc gcagtgggtg gggagtgttg    240

 ttaaccggag gggcagccgc agtcgcgcgg attgagcggg ctcgcggcgc tgggttcctg    300

 gtctccgggc cagggca   atg ttc cgc acg gca gtg atg atg gcg gcc agc     350
                      Met Phe Arg Thr Ala Val Met Met Ala Ala Ser
                        1               5                  10

 ctg gcg ctg acc ggg gct gtg gtg gct cac gcc tac tac ctc aaa cac      398
 Leu Ala Leu Thr Gly Ala Val Val Ala His Ala Tyr Tyr Leu Lys His
              15                  20                  25

 cag ttc tac ccc act gtg gtg tac ctg acc aag tcc agc ccc agc atg      446
 Gln Phe Tyr Pro Thr Val Val Tyr Leu Thr Lys Ser Ser Pro Ser Met
          30                  35                  40

 gca gtc ctg tac atc cag gcc ttt gtc ctt gtc ttc ctt ctg ggc aag      494
 Ala Val Leu Tyr Ile Gln Ala Phe Val Leu Val Phe Leu Leu Gly Lys
      45                  50                  55

 gtg atg ggc aag gtg ttc ttt ggg caa ctg agg gca gca gag atg gag      542
 Val Met Gly Lys Val Phe Phe Gly Gln Leu Arg Ala Ala Glu Met Glu
  60                  65                  70                  75

 cac ctt ctg gaa cgt tcc tgg tac gcc gtc aca gag act tgt ctg gcc      590
 His Leu Leu Glu Arg Ser Trp Tyr Ala Val Thr Glu Thr Cys Leu Ala
                  80                  85                  90

 ttc acc gtt ttt cgg gat gac ttc agc ccc cgc ttt gtt gca ctc ttc      638
 Phe Thr Val Phe Arg Asp Asp Phe Ser Pro Arg Phe Val Ala Leu Phe
              95                 100                 105

 act ctt ctt ctc ttc ctc aaa tgt ttc cac tgg ctg gct gag gac cgt      686
 Thr Leu Leu Leu Phe Leu Lys Cys Phe His Trp Leu Ala Glu Asp Arg
         110                 115                 120

 gtg gac ttt atg gaa cgc agc ccc aac atc tcc tgg ctc ttt cac tgc      734
 Val Asp Phe Met Glu Arg Ser Pro Asn Ile Ser Trp Leu Phe His Cys
     125                 130                 135

 cgc att gtc tct ctt atg ttc ctc ctg ggc atc ctg gac ttc ctc ttc      782
 Arg Ile Val Ser Leu Met Phe Leu Leu Gly Ile Leu Asp Phe Leu Phe
 140                 145                 150                 155

 gtc agc cac gcc tat cac agc atc ctg acc cgt ggg gcc tct gtg cag      830
 Val Ser His Ala Tyr His Ser Ile Leu Thr Arg Gly Ala Ser Val Gln
                 160                 165                 170

 ctg gtg ttt ggc ttt gag tat gcc atc ctg atg acg atg gtg ctc acc      878
 Leu Val Phe Gly Phe Glu Tyr Ala Ile Leu Met Thr Met Val Leu Thr
             175                 180                 185

 atc ttc atc aag tat gtg ctg cac tcc gtg gac ctc cag agt gag aac      926
 Ile Phe Ile Lys Tyr Val Leu His Ser Val Asp Leu Gln Ser Glu Asn
         190                 195                 200

 ccc tgg gac aac aag gct gtg tac atg ctc tac aca gag ctg ttt aca      974
 Pro Trp Asp Asn Lys Ala Val Tyr Met Leu Tyr Thr Glu Leu Phe Thr
     205                 210                 215

 ggc ttc atc aag gtt ctg ctg tac atg gcc ttc atg acc atc atg atc     1022
 Gly Phe Ile Lys Val Leu Leu Tyr Met Ala Phe Met Thr Ile Met Ile
 220                 225                 230                 235

 aag gtg cac acc ttc cca ctc ttt gcc atc cgg ccc atg tac ctg gcc     1070
 Lys Val His Thr Phe Pro Leu Phe Ala Ile Arg Pro Met Tyr Leu Ala
                 240                 245                 250

 atg aga cag ttc aag aaa gct gtg aca gat gcc atc atg tct cgc cga     1118
 Met Arg Gln Phe Lys Lys Ala Val Thr Asp Ala Ile Met Ser Arg Arg
             255                 260                 265

 gcc atc cgc aac atg aac acc ctg tat cca gat gcc acc cca gag gag     1166
 Ala Ile Arg Asn Met Asn Thr Leu Tyr Pro Asp Ala Thr Pro Glu Glu
         270                 275                 280

 ctc cag gca atg gac aat gtc tgc atc atc tgc cga gaa gag atg gtg     1214
 Leu Gln Ala Met Asp Asn Val Cys Ile Ile Cys Arg Glu Glu Met Val
     285                 290                 295

 act ggt gcc aag aga ctg ccc tgc aac cac att ttc cat acc agc tgc     1262
 Thr Gly Ala Lys Arg Leu Pro Cys Asn His Ile Phe His Thr Ser Cys
 300                 305                 310                 315

 ctg cgc tcc tgg ttc cag cgg cag cag acc tgc ccc acc tgc cgt atg     1310
 Leu Arg Ser Trp Phe Gln Arg Gln Gln Thr Cys Pro Thr Cys Arg Met
                 320                 325                 330

 gat gtc ctt cgt gca tcg ctg cca gcg cag tca cca cca ccc ccg gag     1358
 Asp Val Leu Arg Ala Ser Leu Pro Ala Gln Ser Pro Pro Pro Pro Glu
             335                 340                 345

 cct gcg gat cag ggg cca ccc cct gcc ccc cac ccc cca cca ctc tta     1406
 Pro Ala Asp Gln Gly Pro Pro Pro Ala Pro His Pro Pro Pro Leu Leu
         350                 355                 360

 cct cac ccc ccc aac tgc atg ttc cca ctg tgg ccc ccc atg ggc ccc     1454
 Pro His Pro Pro Asn Cys Met Phe Pro Leu Trp Pro Pro Met Gly Pro
     365                 370                 375

 ttt cca cct gtc ccg cct ccc ccc agc tca gga gag gct gtg gct cct     1502
 Phe Pro Pro Val Pro Pro Pro Pro Ser Ser Gly Glu Ala Val Ala Pro
 380                 385                 390                 395

 cca tcc acc agt gca gca gcc ctt tct cgg ccc agt gga gca gct aca     1550
 Pro Ser Thr Ser Ala Ala Ala Leu Ser Arg Pro Ser Gly Ala Ala Thr
                 400                 405                 410

 acc aca gct gct ggc acc agt gct act gct gct tct gcc aca gca tct     1598
 Thr Thr Ala Ala Gly Thr Ser Ala Thr Ala Ala Ser Ala Thr Ala Ser
             415                 420                 425

 ggc cca ggc tct ggc tct gcc cca gaa gct ggc cct gcc cct ggt ttc     1646
 Gly Pro Gly Ser Gly Ser Ala Pro Glu Ala Gly Pro Ala Pro Gly Phe
         430                 435                 440

 ccc ttc cct cct ccc tgg atg ggt atg ccc ctg cct cca ccc ttt gcc     1694
 Pro Phe Pro Pro Pro Trp Met Gly Met Pro Leu Pro Pro Pro Phe Ala
     445                 450                 455

 ttc ccc cca atg cct gtg ccc cct gcg ggc ttt gct ggg ctg acc cca     1742
 Phe Pro Pro Met Pro Val Pro Pro Ala Gly Phe Ala Gly Leu Thr Pro
 460                 465                 470                 475

 gag gag cta cga gct ctg gag ggc cat gag cgg cag cac ctg gag gcc     1790
 Glu Glu Leu Arg Ala Leu Glu Gly His Glu Arg Gln His Leu Glu Ala
                 480                 485                 490

 cgg ctg cag agc ctg cgt aac atc cac aca ctg ctg gac gcc gcc atg     1838
 Arg Leu Gln Ser Leu Arg Asn Ile His Thr Leu Leu Asp Ala Ala Met
             495                 500                 505

 ctg cag atc aac cag tac ctc acc gtg ctg gcc tcc ttg ggg tgt gtc     1886
 Leu Gln Ile Asn Gln Tyr Leu Thr Val Leu Ala Ser Leu Gly Cys Val
         510                 515                 520

 tgt aca ggg gaa gca gag tgg gtt tgg tgg gtc agg agt gga gct gcc     1934
 Cys Thr Gly Glu Ala Glu Trp Val Trp Trp Val Arg Ser Gly Ala Ala
     525                 530                 535

 aag agg tcc cca gca gtg gtt ctt ggc ctt tga cacctgcc aattcaggct     1985
 Lys Arg Ser Pro Ala Val Val Leu Gly Leu 
 540                 545

 gcctatctac aggcccacca agggtctcca ggagttcttg gtaactcctg gtgcctttat   2045

 ttcctactta gatccagaca tgctttctgg agtggga                            2082




      <210> 365
      <211> 1796
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (321)..(1796)

      <400> 365
 ccgggacgac gatttcgtgt ccccctggtg tcctttccac agatatttgc tactttctct     60

 tgaagcacat gaggagaagc cttagcaacc tcaataccga agttcttcgc gcgctcgctc    120

 tttctgcctc cgcccgaact atgcctgagt ccctcacagg agttgggtag tagaggcgag    180

 agaaggaagt ctttgcaggc caaaattggg acaacctgct tggacttccg cctcccggcc    240

 tccggaaggc agtgcgcacg cgctcgctgc gactccggcg cggttgactt ccgctcccac    300

 tgtgctctgc gagccgaatc    atg gat cac act gac aat gag tta caa ggc     350
                          Met Asp His Thr Asp Asn Glu Leu Gln Gly
                            1               5                  10

 act aat agt tct gga tcc ttg ggt ggt ctt gat gtt cgc aga cga att      398
 Thr Asn Ser Ser Gly Ser Leu Gly Gly Leu Asp Val Arg Arg Arg Ile
                  15                  20                  25

 cct ata aag ctc atc tcc aaa caa gca aac aaa gcg aaa cct gca ccg      446
 Pro Ile Lys Leu Ile Ser Lys Gln Ala Asn Lys Ala Lys Pro Ala Pro
              30                  35                  40

 cga act caa aga act ata aac agg atg cct gca aag gct cca cct ggt      494
 Arg Thr Gln Arg Thr Ile Asn Arg Met Pro Ala Lys Ala Pro Pro Gly
          45                  50                  55

 gat gaa gaa gga ttt gat tat aat gaa gaa gaa cgg tat gac tgt aaa      542
 Asp Glu Glu Gly Phe Asp Tyr Asn Glu Glu Glu Arg Tyr Asp Cys Lys
      60                  65                  70

 ggg ggt gag ctg ttt gca aat cag cga aga ttt cct gga cac ctt ttt      590
 Gly Gly Glu Leu Phe Ala Asn Gln Arg Arg Phe Pro Gly His Leu Phe
  75                  80                  85                  90

 tgg gac ttt cag ata aac atc tta ggt gaa aag gat gat aca cca gtt      638
 Trp Asp Phe Gln Ile Asn Ile Leu Gly Glu Lys Asp Asp Thr Pro Val
                  95                 100                 105

 cat ttc tgt gac aag tgt gga ttg cct att aaa atc tat ggg aga atg      686
 His Phe Cys Asp Lys Cys Gly Leu Pro Ile Lys Ile Tyr Gly Arg Met
             110                 115                 120

 att cca tgc aag cat gtt ttt tgc tat gac tgt gct att tta cat gaa      734
 Ile Pro Cys Lys His Val Phe Cys Tyr Asp Cys Ala Ile Leu His Glu
         125                 130                 135

 aaa aag gga gat aag atg tgt cca ggc tgt agt gat cct gtg cag cga      782
 Lys Lys Gly Asp Lys Met Cys Pro Gly Cys Ser Asp Pro Val Gln Arg
     140                 145                 150

 att gag cag tgt aca cga ggt tct ctc ttc atg tgt agc att gtt caa      830
 Ile Glu Gln Cys Thr Arg Gly Ser Leu Phe Met Cys Ser Ile Val Gln
 155                 160                 165                 170

 ggg tgc aag aga aca tat ttg tct cag aga gac tta cag gct cat atc      878
 Gly Cys Lys Arg Thr Tyr Leu Ser Gln Arg Asp Leu Gln Ala His Ile
                 175                 180                 185

 aac cat cgc cat atg aga gct gga aaa cct gtt acc cgt gct tca ctt      926
 Asn His Arg His Met Arg Ala Gly Lys Pro Val Thr Arg Ala Ser Leu
             190                 195                 200

 gaa aat gtt cat cct cct att gcc cca cca cca act gaa atc cct gag      974
 Glu Asn Val His Pro Pro Ile Ala Pro Pro Pro Thr Glu Ile Pro Glu
         205                 210                 215

 cgt ttt ata atg cca cca gac aag cac cat atg agc cat att ccg cca     1022
 Arg Phe Ile Met Pro Pro Asp Lys His His Met Ser His Ile Pro Pro
     220                 225                 230

 aag cag cac atc atg atg cca cca cct cct ttg caa cat gtg cca cat     1070
 Lys Gln His Ile Met Met Pro Pro Pro Pro Leu Gln His Val Pro His
 235                 240                 245                 250

 gag cac tat aat cag cca cat gag gat att cgt gct cct cca gca gaa     1118
 Glu His Tyr Asn Gln Pro His Glu Asp Ile Arg Ala Pro Pro Ala Glu
                 255                 260                 265

 ttg tcc atg gct cca cct cca cct cga tcg gtc agt cag gaa acc ttt     1166
 Leu Ser Met Ala Pro Pro Pro Pro Arg Ser Val Ser Gln Glu Thr Phe
             270                 275                 280

 cgt att tca aca aga aaa cac agc aat tta ata acc gtc cct att cag     1214
 Arg Ile Ser Thr Arg Lys His Ser Asn Leu Ile Thr Val Pro Ile Gln
         285                 290                 295

 gat gac tca aat tca ggt gct aga gaa cca cca cct cct gcc cca gca     1262
 Asp Asp Ser Asn Ser Gly Ala Arg Glu Pro Pro Pro Pro Ala Pro Ala
     300                 305                 310

 cct gct cac cat cat cct gaa tat cag ggt caa cca gtg gta tcg cac     1310
 Pro Ala His His His Pro Glu Tyr Gln Gly Gln Pro Val Val Ser His
 315                 320                 325                 330

 cct cat cat att atg cct cca cag caa cat tat gca cca ccc cca cct     1358
 Pro His His Ile Met Pro Pro Gln Gln His Tyr Ala Pro Pro Pro Pro
                 335                 340                 345

 cct cca cca cca ata agc cat cca atg cca cat cct ccc cag gct gca     1406
 Pro Pro Pro Pro Ile Ser His Pro Met Pro His Pro Pro Gln Ala Ala
             350                 355                 360

 ggt act cct cac ttg gta tat agc caa gct cca cct cca cca atg acc     1454
 Gly Thr Pro His Leu Val Tyr Ser Gln Ala Pro Pro Pro Pro Met Thr
         365                 370                 375

 tct gct cca cca cca ata acc cct ccc cct gga cat att att gcc cag     1502
 Ser Ala Pro Pro Pro Ile Thr Pro Pro Pro Gly His Ile Ile Ala Gln
     380                 385                 390

 atg cca cct tat atg aat cat cct cct cca gga cct ccc cca cct caa     1550
 Met Pro Pro Tyr Met Asn His Pro Pro Pro Gly Pro Pro Pro Pro Gln
 395                 400                 405                 410

 cat ggt ggt cca cct gta act gca ccc cct cct cac cat tat aat cct     1598
 His Gly Gly Pro Pro Val Thr Ala Pro Pro Pro His His Tyr Asn Pro
                 415                 420                 425

 aac tca tta ccc cag ttc act gaa gat caa gga act ctg agc cct cca     1646
 Asn Ser Leu Pro Gln Phe Thr Glu Asp Gln Gly Thr Leu Ser Pro Pro
             430                 435                 440

 ttt aca caa cca ggg gga atg agt cct ggt ata tgg cct gca cca aga     1694
 Phe Thr Gln Pro Gly Gly Met Ser Pro Gly Ile Trp Pro Ala Pro Arg
         445                 450                 455

 ggg cca cca cca cct cca cga ttg cag ggt ccg cct tct caa acc cca     1742
 Gly Pro Pro Pro Pro Pro Arg Leu Gln Gly Pro Pro Ser Gln Thr Pro
     460                 465                 470

 ctt cct gga cca cat cat cca gat cag aca aga tat aga ccg tat tac     1790
 Leu Pro Gly Pro His His Pro Asp Gln Thr Arg Tyr Arg Pro Tyr Tyr
 475                 480                 485                 490

 caa tga                                                             1796
 Gln 






      <210> 366
      <211> 1426
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (196)..(876)

      <400> 366
 aacgcgtccg atttccgaga gagcgggagc gtctgtacct ctgcggcgtc actgggagcc     60

 cgacggaaaa ctgcgctaaa ggcttgtctt tcccctgccc gaccgaagga gccgaccttg    120

 cctgcgctac agcttcctta ttttcgtcgc ctgttctcct gatcctgcgt gttctaaaaa    180

 ccccttaggc tttcc atg ggt tcc cag acc atg gcg gtg gcg ctg ccc agg     231
                  Met Gly Ser Gln Thr Met Ala Val Ala Leu Pro Arg
                    1               5                  10

 gac ttg cgg cag gac gcc aac ctg gca aag agg agg cac gcg gag ctg      279
 Asp Leu Arg Gln Asp Ala Asn Leu Ala Lys Arg Arg His Ala Glu Leu
          15                  20                  25

 tgc agg cag aag cgg gtc ttc aac gcc aga aac agg ata att ggg gga      327
 Cys Arg Gln Lys Arg Val Phe Asn Ala Arg Asn Arg Ile Ile Gly Gly
      30                  35                  40

 gac act gaa gcc tgg gat gtt caa gtt cat gac cag aag ata aaa gaa      375
 Asp Thr Glu Ala Trp Asp Val Gln Val His Asp Gln Lys Ile Lys Glu
  45                  50                  55                  60

 gct act gaa aaa gct aga cat gaa acc ttt gct gct gaa atg agg caa      423
 Ala Thr Glu Lys Ala Arg His Glu Thr Phe Ala Ala Glu Met Arg Gln
                  65                  70                  75

 aat gac aaa atc atg tgc ata ttg gaa aac cgg aaa aag agg gat agg      471
 Asn Asp Lys Ile Met Cys Ile Leu Glu Asn Arg Lys Lys Arg Asp Arg
              80                  85                  90

 aaa aat ctc tgt agg gct atc aat gac ttc caa cag aga ttt cag aag      519
 Lys Asn Leu Cys Arg Ala Ile Asn Asp Phe Gln Gln Arg Phe Gln Lys
          95                 100                 105

 cca gaa act cgc cgt gaa ttt gat ctg tcc gac ccc cta gcc ctt aag      567
 Pro Glu Thr Arg Arg Glu Phe Asp Leu Ser Asp Pro Leu Ala Leu Lys
     110                 115                 120

 aaa gat ctt cca gcc cgg cag tca gat aat gat gtt cgg aat acg ata      615
 Lys Asp Leu Pro Ala Arg Gln Ser Asp Asn Asp Val Arg Asn Thr Ile
 125                 130                 135                 140

 tca gga atg cag aaa ttc atg gga gag gat tta aac ttc cat gag agg      663
 Ser Gly Met Gln Lys Phe Met Gly Glu Asp Leu Asn Phe His Glu Arg
                 145                 150                 155

 aag aaa ttc caa gag gaa caa aac aga gaa tgg tct ttg cag cag caa      711
 Lys Lys Phe Gln Glu Glu Gln Asn Arg Glu Trp Ser Leu Gln Gln Gln
             160                 165                 170

 agg gaa tgg aag aac gcc cgt gct gaa caa aaa tgc gca gag gcc ctc      759
 Arg Glu Trp Lys Asn Ala Arg Ala Glu Gln Lys Cys Ala Glu Ala Leu
         175                 180                 185

 tac aca gag aca agg ctg cag ttt gac gag aca gcc aag cac ctc cag      807
 Tyr Thr Glu Thr Arg Leu Gln Phe Asp Glu Thr Ala Lys His Leu Gln
     190                 195                 200

 aag ctg gaa agc acc acc aga aag gca gtt tgt gca tct gtg aaa gac      855
 Lys Leu Glu Ser Thr Thr Arg Lys Ala Val Cys Ala Ser Val Lys Asp
 205                 210                 215                 220

 ttc aac aag agc cag gta tag gt actccgcgac ctcgggctcg acgactggag      908
 Phe Asn Lys Ser Gln Val 
                 225

 gggaggatga gcccactacg gcttcccaag gctctccggc ttccctggga tcccagtctc    968

 agcctgctcc ctggtcacat gaccggccct gacagagacc ctgatgggct gcctgatgac   1028

 agagatggat gagacccagt cctgtgcctt agctctgaat cttggaggga aacctgccaa   1088

 actagccatg taacctgggg aagtcagctc acctttctac acctcggttt cttcttctgt   1148

 aacatgagga tggtgacatc cacctagact gttaccgcct agctctgctc cactgcctgg   1208

 tgctggtttc cattcttccc acctctcaga cttccccttt actgagaaca gctacttgga   1268

 tgctcaccga tggcagggat gatgaagaag atcataatga gctcgaacac tggggcctcc   1328

 tgagacctcc cgcctcctct ctaaactctg gcccccctcc tcccacacac tcccctcccc   1388

 tccaacctga tgctgaaatt gctgaaaaaa aaaaaaaa                           1426




      <210> 367
      <211> 1227
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (252)..(692)

      <400> 367
 gcccagctca ctgaagagct ttctggtctc ttcattcatc ttggtggctg ggtcgtcgta     60

 ggatgccacg aacaccaggg tgccttcgtg cagtggccga ataaacttca acaggtcgtt    120

 gacatctggg ggggcaggtg ccacggaaca gggctgctgc tcagagcaaa ttaggtcact    180

 acacagatgc gataaaggat tgtgaaaaag caatagcaat tgactcaaag tacagcaagg    240

 cctatgggag a atg ggg ctg gcc ctc act gcc ttg aat aaa ttt gaa gaa     290
              Met Gly Leu Ala Leu Thr Ala Leu Asn Lys Phe Glu Glu
                1               5                  10

 gca gtt aca agt tat caa aag gca tta gat ctt gac cct gaa aat gat      338
 Ala Val Thr Ser Tyr Gln Lys Ala Leu Asp Leu Asp Pro Glu Asn Asp
      15                  20                  25

 tcc tat aag tca aat ctg aaa ata gca gaa cag aag tta aga gag gta      386
 Ser Tyr Lys Ser Asn Leu Lys Ile Ala Glu Gln Lys Leu Arg Glu Val
  30                  35                  40                  45

 tcc agt cct aca gga act gga ctg agc ttt gac atg gct agc ttg ata      434
 Ser Ser Pro Thr Gly Thr Gly Leu Ser Phe Asp Met Ala Ser Leu Ile
                  50                  55                  60

 aat aat cca gcc ttc att agt atg gcg gca agt tta atg cag aac cct      482
 Asn Asn Pro Ala Phe Ile Ser Met Ala Ala Ser Leu Met Gln Asn Pro
              65                  70                  75

 caa gtt caa cag cta atg tca gga atg atg aca aat gcc att ggg gga      530
 Gln Val Gln Gln Leu Met Ser Gly Met Met Thr Asn Ala Ile Gly Gly
          80                  85                  90

 cct gct gct gga gtt ggg ggc cta act gac ctg tca agc ctc atc caa      578
 Pro Ala Ala Gly Val Gly Gly Leu Thr Asp Leu Ser Ser Leu Ile Gln
      95                 100                 105

 gcg gga cag cag ttt gct cag cag ata cag caa caa aat cct gaa ctt      626
 Ala Gly Gln Gln Phe Ala Gln Gln Ile Gln Gln Gln Asn Pro Glu Leu
 110                 115                 120                 125

 ata gag caa ctg aga aat cac atc cgg agc aga tca ttc agc agc agc      674
 Ile Glu Gln Leu Arg Asn His Ile Arg Ser Arg Ser Phe Ser Ser Ser
                 130                 135                 140

 gct gaa gag cat tcc tga tttaac caggggctca agcccaagat acaaatggtt      728
 Ala Glu Glu His Ser 
             145

 tatggctatg aatgaagtat ttgttgtaga tagtaccccc tccctccttc aaaaaaccaa    788

 acaccatatc tgatgtgtga aaataatgga ggaaaacctc ttgtgtatat tcttaaagaa    848

 taaatctgtt tagacaatag gtttatcaca aacaaactca aaacataaca tgactccttt    908

 tgaaatgatc actagccatg ttacgtgcca atatagcact gggataaggt tccattttca    968

 aacttctatc atatttgtat attagactta atagcaaagc atatttattg aactctagta   1028

 gggctatttg ttggtaagct ctttagctcc aatttccctt aagcaaagtt ttttgagaag   1088

 ggaaatgacc caaaggaaag gtttcctatg ctggttgaga agaagtgtac ttgccactga   1148

 gcagtatgtc aggaaagaag gaatattatc taggtttagc tttgataagt gatattagta   1208

 atgaatatat aacctccgg                                                1227




      <210> 368
      <211> 1915
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(465)

      <400> 368
 ttgcagctta ttttcttttt attgtattta attccgaaag aatggtcaca cttctttgct     60

 aggtaggcaa gatgttccgg aggacacact agagaaagca ccactcccca ccctaaccca    120

 catccccaac acactcacct gcccacactc acacaatcac atacacatgc ccacacttat    180

 atacac   atg ctg aca ccc gtg cac tca tgt gca cac act cat tca cac     228
          Met Leu Thr Pro Val His Ser Cys Ala His Thr His Ser His
            1               5                  10

 tca tac ata ttc aca ctc agg cat act cat act cct cat gag cac acc      276
 Ser Tyr Ile Phe Thr Leu Arg His Thr His Thr Pro His Glu His Thr
  15                  20                  25                  30

 aca ctc acc tgt gca cac tca cct gtg cac act cac aca cat gca gac      324
 Thr Leu Thr Cys Ala His Ser Pro Val His Thr His Thr His Ala Asp
                  35                  40                  45

 act cat ggg cac act cac aca tgc tca cat gct cat ttg cac cca gac      372
 Thr His Gly His Thr His Thr Cys Ser His Ala His Leu His Pro Asp
              50                  55                  60

 aca ggc ata cac atc att tgt atg cac aca cgc aca ctt ttt aac gtg      420
 Thr Gly Ile His Ile Ile Cys Met His Thr Arg Thr Leu Phe Asn Val
          65                  70                  75

 gta acg att tac agg aaa gaa cag ctg gaa ctc gtg ctg gga taa cca      468
 Val Thr Ile Tyr Arg Lys Glu Gln Leu Glu Leu Val Leu Gly 
      80                  85                  90

 ggtacaagtg ctctctgcag agaataagtg cacacaggtt ggtgtcttct gaccgagagc    528

 cctcctgaag ggaggtctgt acctcctccc tcatctcatt ttacacaagg cgacaggtca    588

 gaggccaggg tgggacgaga gcgagggagc actgtctctg gcagcagcac ttgccactcc    648

 acaatgtgga gaccagaacg gcaccccaga gagcacgggg gaaatggctc atctttaaaa    708

 caatggcaga agaaatccag ccaaggtcac ttttcctgtg tgagcatgtt taaggccaga    768

 gagtggctac ttctctgcct cctgcagctc cctcagtgtg gcttggagga gtcggcgaag    828

 cttccagaac acgctggagg ctgctctccg ggtgttccca ctggggaccc cagggtctgc    888

 acattcctgc accgcctcct gtaactgcag ctgaagctgg aaagagaccg cagagctctt    948

 gagaggcgcg gaaaaccaat ggcgaaatat tttgtcacag atgacctgca ggttgttgtt   1008

 tacgcgctgc gctccgcatt tgttgactcg taaatcacat cttgaaaaac agtcaaagaa   1068

 attgcagtct tcatctcctg tgcagttttg ctcaaggatt tccctcattt taggttcaaa   1128

 aaaggccatg tccacatcaa tagccaccac tgtgaagtcg ctccggatgg caaagttttc   1188

 cggcttgatg tcgcagaggt ggaggcggtg ggaaaagtca ctgtcaaaat ggttcaccat   1248

 gtccaagaag ctgagtgcga tgtcactgat ggccttggcc tggccacccc caggggcacc   1308

 tggggcccgg tccaggggga agagtgccct gtggtggggg ctgcccgcgg ccaggaactc   1368

 caccgcgtag aagtggccgc aggaacccag cacgggcagc acgtgtgggc tcaggtcctg   1428

 cagcaggctg aagtagacgt actcctcctg ctgcagcagg gcccacaggc tggccagctg   1488

 tccccgccag cgtgggcccc gcctgcccgg ccaccacggc cccaggctgc tgttggacaa   1548

 ctccaggccc agagcgctct tgacctcccc agccaccatc aggaggagtt cggcctcggg   1608

 catgtcctgg ccaccctccc ctgcctcctc ttccaacagg ctgaggggcg ggaagctgga   1668

 gaaggcctcc tccttggact tgaggaccac gggccggccg cgccagtcgg cctgcagcac   1728

 cttcttgcct ctgttgtagt gcaggcagcg ttggaacagc agctttcccg ccacacacag   1788

 gtcctcgcag aggtccccgg ccagcgtgcc gccctggtag tcctggcaca gcgcggccag   1848

 gatgcgccgg ctcttctcgt cggtgcagcg ctcggagagg acacccgggt gcgcgcggag   1908

 cagcagc                                                             1915




      <210> 369
      <211> 1245
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (90)..(995)

      <400> 369
 cacagccgaa gggaaagcag caggttgggg cttcttgtgg ccaacttcag agcctgtcac     60

 caggaaaggt aagcatggga ggaaggaag  atg gcg aca gat gaa gaa aat gtc     113
                                  Met Ala Thr Asp Glu Glu Asn Val
                                    1               5

 tat ggt tta gaa gag aac gct cag tcc cgg cag gag tcc acg cgg agg      161
 Tyr Gly Leu Glu Glu Asn Ala Gln Ser Arg Gln Glu Ser Thr Arg Arg
      10                  15                  20

 ctc atc ctt gtt ggg aga aca ggg gcc ggg aag agc gcc act ggg aac      209
 Leu Ile Leu Val Gly Arg Thr Gly Ala Gly Lys Ser Ala Thr Gly Asn
  25                  30                  35                  40

 agc atc ctg ggc cag aga cgg ttc ttc tcc agg ctg ggg gcc acg tct      257
 Ser Ile Leu Gly Gln Arg Arg Phe Phe Ser Arg Leu Gly Ala Thr Ser
                  45                  50                  55

 gtg acc agg gcc tgc acc acg ggc agc cgc agg tgg gac aag tgc cac      305
 Val Thr Arg Ala Cys Thr Thr Gly Ser Arg Arg Trp Asp Lys Cys His
              60                  65                  70

 gtg gaa gtc gtg gac act ccg gac att ttc agc tcc caa gtg tcc aag      353
 Val Glu Val Val Asp Thr Pro Asp Ile Phe Ser Ser Gln Val Ser Lys
          75                  80                  85

 aca gat cct ggc tgt gag gag aga ggt cac tgc tac ctg ctc tcg gcc      401
 Thr Asp Pro Gly Cys Glu Glu Arg Gly His Cys Tyr Leu Leu Ser Ala
      90                  95                 100

 ccc gga ccc cac gcg ctg ctc ctg gtg acc cag ttg ggt cgg ttc acc      449
 Pro Gly Pro His Ala Leu Leu Leu Val Thr Gln Leu Gly Arg Phe Thr
 105                 110                 115                 120

 gcc cag gac cag cag gcg gtg agg cag gtg agg gac atg ttc ggg gag      497
 Ala Gln Asp Gln Gln Ala Val Arg Gln Val Arg Asp Met Phe Gly Glu
                 125                 130                 135

 gac gtc cta aaa tgg atg gtc atc gtc ttc acc agg aag gag gac ctg      545
 Asp Val Leu Lys Trp Met Val Ile Val Phe Thr Arg Lys Glu Asp Leu
             140                 145                 150

 gcc ggg ggc tcc ctg cac gat tac gtg agc aac aca gag aac cgg gcc      593
 Ala Gly Gly Ser Leu His Asp Tyr Val Ser Asn Thr Glu Asn Arg Ala
         155                 160                 165

 ttg cgc gag ctg gtg gcc gag tgc ggg ggc cgg gtc tgt gcc ttt gat      641
 Leu Arg Glu Leu Val Ala Glu Cys Gly Gly Arg Val Cys Ala Phe Asp
     170                 175                 180

 aac cgg gcc acc ggc cga gag cag gaa gcc cag gtg gag cag ctg ctg      689
 Asn Arg Ala Thr Gly Arg Glu Gln Glu Ala Gln Val Glu Gln Leu Leu
 185                 190                 195                 200

 ggg atg gtc gag ggc ttg gtg ctg gag cac aag ggc gcc cat tac tcc      737
 Gly Met Val Glu Gly Leu Val Leu Glu His Lys Gly Ala His Tyr Ser
                 205                 210                 215

 aac gag gtg tat gag ctg gcg cag gtg ctg cgc tgg gca ggc cct gag      785
 Asn Glu Val Tyr Glu Leu Ala Gln Val Leu Arg Trp Ala Gly Pro Glu
             220                 225                 230

 gag cgg ctc cgg cgg gtg gcg gag cgc gtg gca gcc agg gtg cag agg      833
 Glu Arg Leu Arg Arg Val Ala Glu Arg Val Ala Ala Arg Val Gln Arg
         235                 240                 245

 agg cca tgg ggc gcc tgg ctg tcg gcc cgg ctg tgg aag tgg ctg aag      881
 Arg Pro Trp Gly Ala Trp Leu Ser Ala Arg Leu Trp Lys Trp Leu Lys
     250                 255                 260

 tcc ccc agg agc tgg agg ctg ggc ctg gcc ctg ctg ctg ggg ggc gcg      929
 Ser Pro Arg Ser Trp Arg Leu Gly Leu Ala Leu Leu Leu Gly Gly Ala
 265                 270                 275                 280

 ctc ctg ttc tgg gtg ctg ctc cac agg cgg tgg tcg gag gcc gtt gcg      977
 Leu Leu Phe Trp Val Leu Leu His Arg Arg Trp Ser Glu Ala Val Ala
                 285                 290                 295

 gag gtc ggg cct gac tga cagcgc aggtcctaaa actgaaggca acttggttaa     1031
 Glu Val Gly Pro Asp 
             300

 gggaggctga attcttggag ctgaagggaa aacttcattc caacggaagg aatcctgtag   1091

 tttcaggcat agttttaatg acacagaaaa ctttgctgca tcacctttgc aactttgcca   1151

 aagctcagag ttcacttttt aagtttttaa ctcattttaa atgatgtgta tgcagagttt   1211

 taaaataaat tcgtctaaca ataaaaaaaa aaaa                               1245




      <210> 370
      <211> 2141
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (433)..(1992)

      <400> 370
 ttggcctaac ttaaattttt aaaacacttc ctggagggga caaacaggac ccatctgctg     60

 gtctgactct gggtgtcctg ttcacagtct ctgtcttagt tgttctgtgt gtgggatgaa    120

 gggtgccaag gagacagggc agggcaggga ccctcaagaa aagcggggag gcggggggaa    180

 gggatggtac aagcagccat ggcacctcag tgtgtccctc aggcacctgg acacacaggt    240

 gggcaaagat gctgacactg ggggccagaa acgccgatac ccccattctt ccatttttac    300

 tcagtctcag gtggtcccaa ggaggggacc ttcgtggcct tgctgtgctc acaggctcac    360

 ctttgtgttt ccagctgcag agaaagtacc ctgggccatg cagctgcact cccctcccag    420

 gaaaggggca gg    atg gct gcc cag atg agt gag gca tca gcc ctg gcc     468
                  Met Ala Ala Gln Met Ser Glu Ala Ser Ala Leu Ala
                    1               5                  10

 ccc cag gtc ttc ccg agt cca ctg gaa ctg atg gtg ggt gag ccc agc      516
 Pro Gln Val Phe Pro Ser Pro Leu Glu Leu Met Val Gly Glu Pro Ser
          15                  20                  25

 tcc aag agc cct ggc cag tgc ttc tgg ggg ttc tgc tat gag aag gca      564
 Ser Lys Ser Pro Gly Gln Cys Phe Trp Gly Phe Cys Tyr Glu Lys Ala
      30                  35                  40

 gca ggg ccc cga ggg gcc ctg gct cag ctg cgt gag ctg tgt tgc cag      612
 Ala Gly Pro Arg Gly Ala Leu Ala Gln Leu Arg Glu Leu Cys Cys Gln
  45                  50                  55                  60

 tgg ctg atg cct gag gcc tgc tcc aag gag cag atg ctg gag ctc ttg      660
 Trp Leu Met Pro Glu Ala Cys Ser Lys Glu Gln Met Leu Glu Leu Leu
                  65                  70                  75

 gtg ctg gag cag tta ttg ggc aca ctg ctc cca gag atc cag gcc tac      708
 Val Leu Glu Gln Leu Leu Gly Thr Leu Leu Pro Glu Ile Gln Ala Tyr
              80                  85                  90

 acg cag gag cag tgg cta ggc agc cct gag gag gcc act gcc ctg gca      756
 Thr Gln Glu Gln Trp Leu Gly Ser Pro Glu Glu Ala Thr Ala Leu Ala
          95                 100                 105

 gag cgg cta cag cag gag tca gct ggg cca gga ctc cag atg aag gag      804
 Glu Arg Leu Gln Gln Glu Ser Ala Gly Pro Gly Leu Gln Met Lys Glu
     110                 115                 120

 ccg ggc tgc cgg tgc ggg gag tgc ggc aag gcg ttc agc cag ggc tct      852
 Pro Gly Cys Arg Cys Gly Glu Cys Gly Lys Ala Phe Ser Gln Gly Ser
 125                 130                 135                 140

 tac ttg ctg cag cat cgg cgc gtg cac aca ggc gag aag ccg tac acg      900
 Tyr Leu Leu Gln His Arg Arg Val His Thr Gly Glu Lys Pro Tyr Thr
                 145                 150                 155

 tgc ccc gag tgc ggc aag gcc ttc gcc tgg agc tcc aac ctc agc cag      948
 Cys Pro Glu Cys Gly Lys Ala Phe Ala Trp Ser Ser Asn Leu Ser Gln
             160                 165                 170

 cac cag cgc atc cac agc ggc gag aag ccc tac gct tgc agg gag tgc      996
 His Gln Arg Ile His Ser Gly Glu Lys Pro Tyr Ala Cys Arg Glu Cys
         175                 180                 185

 ggc aag gcc ttc cgc gcg cac tcg cag ctc atc cac cac cag gag aca     1044
 Gly Lys Ala Phe Arg Ala His Ser Gln Leu Ile His His Gln Glu Thr
     190                 195                 200

 cac agc ggc ctg aag ccc ttc cgc tgc ccg gac tgc ggc aag tcc ttc     1092
 His Ser Gly Leu Lys Pro Phe Arg Cys Pro Asp Cys Gly Lys Ser Phe
 205                 210                 215                 220

 ggc cga agc acc acg ctg gtg cag cac cga cgc acg cac acg ggc gag     1140
 Gly Arg Ser Thr Thr Leu Val Gln His Arg Arg Thr His Thr Gly Glu
                 225                 230                 235

 aag ccc tac gag tgc ccg gag tgc ggc aag gcc ttc agc tgg aac tcc     1188
 Lys Pro Tyr Glu Cys Pro Glu Cys Gly Lys Ala Phe Ser Trp Asn Ser
             240                 245                 250

 aat ttc ctg gag cac cgg cgc gtg cac acg ggc gcg cgg ccg cac gcc     1236
 Asn Phe Leu Glu His Arg Arg Val His Thr Gly Ala Arg Pro His Ala
         255                 260                 265

 tgc cgg gac tgt ggc aag gcc ttc agc cag agc tcc aac ctg gcc gag     1284
 Cys Arg Asp Cys Gly Lys Ala Phe Ser Gln Ser Ser Asn Leu Ala Glu
     270                 275                 280

 cac ctg aag atc cac gcg ggc gca cgg cca cac gcc tgt ccc gac tgc     1332
 His Leu Lys Ile His Ala Gly Ala Arg Pro His Ala Cys Pro Asp Cys
 285                 290                 295                 300

 ggc aag gcc ttc gtg cgt gtg gcg ggg ctg cgg cag cac cgg cgc acg     1380
 Gly Lys Ala Phe Val Arg Val Ala Gly Leu Arg Gln His Arg Arg Thr
                 305                 310                 315

 cac agc agc gag aag ccc ttc ccc tgc gcc gag tgc gga aag gct ttc     1428
 His Ser Ser Glu Lys Pro Phe Pro Cys Ala Glu Cys Gly Lys Ala Phe
             320                 325                 330

 cgc gag agc tcg cag ctc ctg cag cac cag cgc acg cac act ggt gag     1476
 Arg Glu Ser Ser Gln Leu Leu Gln His Gln Arg Thr His Thr Gly Glu
         335                 340                 345

 cgg ccc ttc gag tgc gcc gag tgc ggc cag gct ttc gtc atg ggc tcc     1524
 Arg Pro Phe Glu Cys Ala Glu Cys Gly Gln Ala Phe Val Met Gly Ser
     350                 355                 360

 tac ctg gcg gag cac cgg cgc gtg cac acg ggc gag aag cct cat gcg     1572
 Tyr Leu Ala Glu His Arg Arg Val His Thr Gly Glu Lys Pro His Ala
 365                 370                 375                 380

 tgc gcc cag tgc ggc aag gcc ttc agc cag cgc tcc aac cta ctg agc     1620
 Cys Ala Gln Cys Gly Lys Ala Phe Ser Gln Arg Ser Asn Leu Leu Ser
                 385                 390                 395

 cac cgg cgc acg cac tcg ggc gcc aag ccc ttc gcc tgc gcc gac tgc     1668
 His Arg Arg Thr His Ser Gly Ala Lys Pro Phe Ala Cys Ala Asp Cys
             400                 405                 410

 ggc aag gcc ttc cgc ggc agt tcc ggc ctg gcg cac cac cgg ctt tcg     1716
 Gly Lys Ala Phe Arg Gly Ser Ser Gly Leu Ala His His Arg Leu Ser
         415                 420                 425

 cac acg gga gag cga ccc ttc gcc tgc gca gaa tgc ggc aag gcc ttc     1764
 His Thr Gly Glu Arg Pro Phe Ala Cys Ala Glu Cys Gly Lys Ala Phe
     430                 435                 440

 cgc ggc agc tcc gag ctg cgc cag cac cag cgc ctg cac tct ggc gag     1812
 Arg Gly Ser Ser Glu Leu Arg Gln His Gln Arg Leu His Ser Gly Glu
 445                 450                 455                 460

 agg ccg ttc gtc tgc gcc cac tgc agc aag gcc ttc gtg cgc aag tcg     1860
 Arg Pro Phe Val Cys Ala His Cys Ser Lys Ala Phe Val Arg Lys Ser
                 465                 470                 475

 gag ctc tta agc cac cgg cgc acg cac acg ggc gag agg tcc tac gct     1908
 Glu Leu Leu Ser His Arg Arg Thr His Thr Gly Glu Arg Ser Tyr Ala
             480                 485                 490

 tgc ggc gag tgc ggg aag cct ttc agc cac cgt tgc aac ctc aac gag     1956
 Cys Gly Glu Cys Gly Lys Pro Phe Ser His Arg Cys Asn Leu Asn Glu
         495                 500                 505

 cac cag aag cgg cac ggg ggc cgc gct gcg ccc tga cccg aggacgccct     2006
 His Gln Lys Arg His Gly Gly Arg Ala Ala Pro 
     510                 515

 gagcgggagg tcgcggacac acggcattgc ggggtctcgg gcgtgagtgc gctgtctgct   2066

 ggcccagact ttttcgggcc gccggtgcgg gcgccctcct gctgggagtg caggggcggc   2126

 cttgggtgtg gagat                                                    2141




      <210> 371
      <211> 1125
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (127)..(687)

      <400> 371
 cacgaggccg cccgcaccga gccgcgggac ccgggccgta ccggggaggg gccgctccgg     60

 gccgcagcgc gagggcatcg aggggcggcg gggacctggc accgggcggg gccggcggca    120

 gcgacc   atg atc gct ttg ttc aac aag ctg ctg gac tgg ttc aag gcc     168
          Met Ile Ala Leu Phe Asn Lys Leu Leu Asp Trp Phe Lys Ala
            1               5                  10

 cta ttc tgg aag gag gag atg gag ctc acg ctg gtc ggg ctt cag tac      216
 Leu Phe Trp Lys Glu Glu Met Glu Leu Thr Leu Val Gly Leu Gln Tyr
  15                  20                  25                  30

 tcg ggc aag acc acc ttc gtc aac gtg atc gcg tca gga cag ttc aac      264
 Ser Gly Lys Thr Thr Phe Val Asn Val Ile Ala Ser Gly Gln Phe Asn
                  35                  40                  45

 gag gac atg atc ccc acc gtg ggt ttc aac atg cgc aaa atc acc aaa      312
 Glu Asp Met Ile Pro Thr Val Gly Phe Asn Met Arg Lys Ile Thr Lys
              50                  55                  60

 ggg aat gtg act atc aag ctc tgg gac att ggg gga cag ccg cgt ttc      360
 Gly Asn Val Thr Ile Lys Leu Trp Asp Ile Gly Gly Gln Pro Arg Phe
          65                  70                  75

 cgc agc atg tgg gag cgc tac tgc cga gga gtg agc gcc atc gtg tac      408
 Arg Ser Met Trp Glu Arg Tyr Cys Arg Gly Val Ser Ala Ile Val Tyr
      80                  85                  90

 atg gtg gat gct gct gac cag gag aag att gag gcc tct aag aac gag      456
 Met Val Asp Ala Ala Asp Gln Glu Lys Ile Glu Ala Ser Lys Asn Glu
  95                 100                 105                 110

 ctc cac aac cta ctg gac aaa cct cag ctg cag ggc atc ccg gtc tta      504
 Leu His Asn Leu Leu Asp Lys Pro Gln Leu Gln Gly Ile Pro Val Leu
                 115                 120                 125

 gtc ctg ggt aac aag cga gac ctt ccg gga gca ttg gat gag aag gag      552
 Val Leu Gly Asn Lys Arg Asp Leu Pro Gly Ala Leu Asp Glu Lys Glu
             130                 135                 140

 ctg att gag aaa atg aat ctg tct gcc atc cag gac cga gag atc tgc      600
 Leu Ile Glu Lys Met Asn Leu Ser Ala Ile Gln Asp Arg Glu Ile Cys
         145                 150                 155

 tgc tac tcc atc tct tgc aaa gaa aag gac aac att gac atc acc cta      648
 Cys Tyr Ser Ile Ser Cys Lys Glu Lys Asp Asn Ile Asp Ile Thr Leu
     160                 165                 170

 cag tgg ctt att caa cac tcg aag tca cgg aga agc tga gactccagcc       697
 Gln Trp Leu Ile Gln His Ser Lys Ser Arg Arg Ser 
 175                 180                 185

 cttctccctc agaccaggga ccgtcatcat ctaaacctga agccgagctc cccgcccacc    757

 cctgtcgtcc ccctaagccc acccctcctc acccagtgtg aggagggccc tctggggacc    817

 ccagagtcct gttctgctga ggtttgaact cctgttttta ttgtaaaata aattgcccag    877

 ggcccccacc tccacggccc acttcatttt ctgttctcat tttgcagagt tgcacaagga    937

 gagaactcag catggggggt tggttctttg ggttctgttt gtttatttgt ttaatttaat    997

 gatttgtaaa gtgatgttcc tcttcctttt ttacactttt cagctcatat ttaacctctg   1057

 tttggaaaat gattcttgta actgtacatt tttttgcttc ctaataacaa tgacaacaaa   1117

 aaaaaaaa                                                            1125




      <210> 372
      <211> 1641
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1587)

      <400> 372
  atg gcc aag ttg cct gga ctg ggt ccg ccc ctc ctg ggg ctc ccc gca      48
  Met Ala Lys Leu Pro Gly Leu Gly Pro Pro Leu Leu Gly Leu Pro Ala
    1               5                  10                  15

 tcc agg tgc ccc gtg tgc ccg gcc tgg gcg gct ggc cgt gga tct gac       96
 Ser Arg Cys Pro Val Cys Pro Ala Trp Ala Ala Gly Arg Gly Ser Asp
              20                  25                  30

 cgc tcc tgc atg gtg gag gac cag cgt tcc cac tgt ctg cag ctg tgc      144
 Arg Ser Cys Met Val Glu Asp Gln Arg Ser His Cys Leu Gln Leu Cys
          35                  40                  45

 cac ctc cct gtg ccg ggc ttg ctc ttc gag cgg gag agg acg ggc ctg      192
 His Leu Pro Val Pro Gly Leu Leu Phe Glu Arg Glu Arg Thr Gly Leu
      50                  55                  60

 acc tac cgc gtg ccc tcg ttg ctc ccc gtg ccc ccc ggg ccc acc ctg      240
 Thr Tyr Arg Val Pro Ser Leu Leu Pro Val Pro Pro Gly Pro Thr Leu
  65                  70                  75                  80

 ctg gcc ttt gtg gag cag cgg ctc agc cct gac gac tcc cac gcc cac      288
 Leu Ala Phe Val Glu Gln Arg Leu Ser Pro Asp Asp Ser His Ala His
                  85                  90                  95

 cgc ctg gtg ctg agg agg ggc acg ctg gcc ggg ggc tcc gtg cgg tgg      336
 Arg Leu Val Leu Arg Arg Gly Thr Leu Ala Gly Gly Ser Val Arg Trp
             100                 105                 110

 ggt gcc ctg cac gtg ctg ggg aca gca gcc ctg gcg gag cac cgg tcc      384
 Gly Ala Leu His Val Leu Gly Thr Ala Ala Leu Ala Glu His Arg Ser
         115                 120                 125

 atg aac ccc tgc cct gtg cac gat gct ggc acg ggc acc gtc ttc ctc      432
 Met Asn Pro Cys Pro Val His Asp Ala Gly Thr Gly Thr Val Phe Leu
     130                 135                 140

 ttc ttc atc gcg gtg ctg ggc cac acg cct gag gcc gtg cag atc gcc      480
 Phe Phe Ile Ala Val Leu Gly His Thr Pro Glu Ala Val Gln Ile Ala
 145                 150                 155                 160

 acg gga agg aac gcc gcg cgc ctc tgc tgt gtg gcc agc cgt gac gcc      528
 Thr Gly Arg Asn Ala Ala Arg Leu Cys Cys Val Ala Ser Arg Asp Ala
                 165                 170                 175

 ggc ctc tcg tgg ggc agc gcc cgg gac ctc acc gag gag gcc atc ggt      576
 Gly Leu Ser Trp Gly Ser Ala Arg Asp Leu Thr Glu Glu Ala Ile Gly
             180                 185                 190

 ggt gcc gtg cag gac tgg gcc aca ttc gct gtg ggt ccc ggc cac ggc      624
 Gly Ala Val Gln Asp Trp Ala Thr Phe Ala Val Gly Pro Gly His Gly
         195                 200                 205

 gtg cag ctg ccc tca ggc cgc ctg ctg gta ccc gcc tac acc tac cgc      672
 Val Gln Leu Pro Ser Gly Arg Leu Leu Val Pro Ala Tyr Thr Tyr Arg
     210                 215                 220

 gtg gac cgc cga gag tgt ttt ggc aag atc tgc cgg acc agc cct cac      720
 Val Asp Arg Arg Glu Cys Phe Gly Lys Ile Cys Arg Thr Ser Pro His
 225                 230                 235                 240

 tcc ttc gcc ttc tac agc gat gac cac ggc cgc acc tgg cgc tgt gga      768
 Ser Phe Ala Phe Tyr Ser Asp Asp His Gly Arg Thr Trp Arg Cys Gly
                 245                 250                 255

 ggc ctc gtg ccc aac ctg cgc tca ggc gag tgc cag ctg gcg gcg gtg      816
 Gly Leu Val Pro Asn Leu Arg Ser Gly Glu Cys Gln Leu Ala Ala Val
             260                 265                 270

 gac ggt ggg cag gcc ggc agc ttc ctc tac tgc aat gcc cgg agc cca      864
 Asp Gly Gly Gln Ala Gly Ser Phe Leu Tyr Cys Asn Ala Arg Ser Pro
         275                 280                 285

 ctg ggc agc cgt gtg cag gcg ctc agc act gac gag ggc acc tcc ttc      912
 Leu Gly Ser Arg Val Gln Ala Leu Ser Thr Asp Glu Gly Thr Ser Phe
     290                 295                 300

 ctg ccc gca gag cgc gtg gct tcc ctg ccc gag act gcc tgg ggc tgc      960
 Leu Pro Ala Glu Arg Val Ala Ser Leu Pro Glu Thr Ala Trp Gly Cys
 305                 310                 315                 320

 cag ggc agc atc gtg ggc ttc cca gcc ccc gcc ccc aac agg cca cgg     1008
 Gln Gly Ser Ile Val Gly Phe Pro Ala Pro Ala Pro Asn Arg Pro Arg
                 325                 330                 335

 gat gac agt tgg tca gtg ggc ccc ggg agt ccc ctc cag cct cca ctc     1056
 Asp Asp Ser Trp Ser Val Gly Pro Gly Ser Pro Leu Gln Pro Pro Leu
             340                 345                 350

 ctc ggt cct gga gtc cac gaa ccc cca gag gag gct gct gta gac ccc     1104
 Leu Gly Pro Gly Val His Glu Pro Pro Glu Glu Ala Ala Val Asp Pro
         355                 360                 365

 cgt gga ggc cag gtg cct ggt ggg ccc ttc agc cgt ctg cag cct cgg     1152
 Arg Gly Gly Gln Val Pro Gly Gly Pro Phe Ser Arg Leu Gln Pro Arg
     370                 375                 380

 ggg gat ggc ccc agg cag cct ggc ccc agg cct ggg gtc agt ggg gat     1200
 Gly Asp Gly Pro Arg Gln Pro Gly Pro Arg Pro Gly Val Ser Gly Asp
 385                 390                 395                 400

 gtg ggg tcc tgg acc ctg gca ctc ccc atg ccc ttt gct gcc ccg ccc     1248
 Val Gly Ser Trp Thr Leu Ala Leu Pro Met Pro Phe Ala Ala Pro Pro
                 405                 410                 415

 cag agc ccc acg tgg ctg ctg tac tcc cac cca gtg ggg cgc agg gct     1296
 Gln Ser Pro Thr Trp Leu Leu Tyr Ser His Pro Val Gly Arg Arg Ala
             420                 425                 430

 cgg cta cac atg ggt atc cgc ctg agc cag tcc ccg ctg gac ccg cgc     1344
 Arg Leu His Met Gly Ile Arg Leu Ser Gln Ser Pro Leu Asp Pro Arg
         435                 440                 445

 agc tgg aca gag ccc tgg gtg atc tac gag ggc ccc agc ggc tac tct     1392
 Ser Trp Thr Glu Pro Trp Val Ile Tyr Glu Gly Pro Ser Gly Tyr Ser
     450                 455                 460

 gac ctg gcg tcc atc ggg ccg gcc cct gag ggg ggc ctg gtt ttt gcc     1440
 Asp Leu Ala Ser Ile Gly Pro Ala Pro Glu Gly Gly Leu Val Phe Ala
 465                 470                 475                 480

 tgc ctg tac gag agc ggg gcc agg acc tcc tat gat gag att tcc ttt     1488
 Cys Leu Tyr Glu Ser Gly Ala Arg Thr Ser Tyr Asp Glu Ile Ser Phe
                 485                 490                 495

 tgt aca ttc tcc ctg cgt gag gtc ctg gag aac gtg ccc gcc agc ccc     1536
 Cys Thr Phe Ser Leu Arg Glu Val Leu Glu Asn Val Pro Ala Ser Pro
             500                 505                 510

 aaa ccg ccc aac ctt ggg gac aag cct cgg ggg tgc tgc tgg ccc tcc     1584
 Lys Pro Pro Asn Leu Gly Asp Lys Pro Arg Gly Cys Cys Trp Pro Ser
         515                 520                 525

 tga cagg ccttctggcc gtgcccatgc cccttgggtg cctggggcag aggggtggaa     1641
 






      <210> 373
      <211> 1181
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (148)..(1152)

      <400> 373
 gaaaaggaga agtgaaggat gaccgcctcg ctggaaccac aaaagagagg cttggagggg     60

 tttgtggtcc cctctcagcc accccgaaat gatgtgcaga aatgaggcga tcctggcaac    120

 aggtggagtg gggctcaaag tcagaaa    atg aga tac aag aca tcc ttg gtg     171
                                  Met Arg Tyr Lys Thr Ser Leu Val
                                    1               5

 atg agg aaa cga tta cgg ctt tac cga aac act ctt aaa gag tca agt      219
 Met Arg Lys Arg Leu Arg Leu Tyr Arg Asn Thr Leu Lys Glu Ser Ser
      10                  15                  20

 agc agc tct gga cac cat ggc ccc cag ctc acc gcc gcc tcc agc ccc      267
 Ser Ser Ser Gly His His Gly Pro Gln Leu Thr Ala Ala Ser Ser Pro
  25                  30                  35                  40

 tcg gtg ttc ccg ggc ctc cac gag gag cct ccc cag gcc tcc ccc agc      315
 Ser Val Phe Pro Gly Leu His Glu Glu Pro Pro Gln Ala Ser Pro Ser
                  45                  50                  55

 cgt cct ttg aat gga ctc ctg cgt ctg ggg ctc cct gga gac atg tac      363
 Arg Pro Leu Asn Gly Leu Leu Arg Leu Gly Leu Pro Gly Asp Met Tyr
              60                  65                  70

 gcg cgg ccg gag ccc ttc ccg cca ggg cct gcg gcc cgc agc gac gcc      411
 Ala Arg Pro Glu Pro Phe Pro Pro Gly Pro Ala Ala Arg Ser Asp Ala
          75                  80                  85

 ctg gca gct gcc gca gcc ctg cat ggc tac ggg ggc atg aac ctg acg      459
 Leu Ala Ala Ala Ala Ala Leu His Gly Tyr Gly Gly Met Asn Leu Thr
      90                  95                 100

 gtg aac ctc gct gcg ccc cac ggt cct ggc gct ttc ttc cgc tac atg      507
 Val Asn Leu Ala Ala Pro His Gly Pro Gly Ala Phe Phe Arg Tyr Met
 105                 110                 115                 120

 cgc cag ccc atc aaa cag gag ctc atc tgc aag tgg ctg gcg gcc gac      555
 Arg Gln Pro Ile Lys Gln Glu Leu Ile Cys Lys Trp Leu Ala Ala Asp
                 125                 130                 135

 ggc acc gcg acc ccg agc ctc tgc tcc aaa act ttc agc acc atg cac      603
 Gly Thr Ala Thr Pro Ser Leu Cys Ser Lys Thr Phe Ser Thr Met His
             140                 145                 150

 gag ctg gtc acg cac gtc acc gtg gag cac gtc ggc ggc ccg gaa cag      651
 Glu Leu Val Thr His Val Thr Val Glu His Val Gly Gly Pro Glu Gln
         155                 160                 165

 gcc aac cac att tgc ttc tgg gag gag tgt ccg cgc cag gga aag ccc      699
 Ala Asn His Ile Cys Phe Trp Glu Glu Cys Pro Arg Gln Gly Lys Pro
     170                 175                 180

 ttc aaa gcc aaa tac aaa ctt gta aat cac atc cgc gtg cac acg ggc      747
 Phe Lys Ala Lys Tyr Lys Leu Val Asn His Ile Arg Val His Thr Gly
 185                 190                 195                 200

 gag aag ccc ttc cct tgt cct ttc ccg ggg tgt ggg aag gtc ttt gct      795
 Glu Lys Pro Phe Pro Cys Pro Phe Pro Gly Cys Gly Lys Val Phe Ala
                 205                 210                 215

 aga tca gaa aat ctc aaa ata cac aaa cga act cac aca ggc gag aag      843
 Arg Ser Glu Asn Leu Lys Ile His Lys Arg Thr His Thr Gly Glu Lys
             220                 225                 230

 ccc ttc aga tgc gag ttc gag ggc tgc gag cgg cgc ttc gcc aac agc      891
 Pro Phe Arg Cys Glu Phe Glu Gly Cys Glu Arg Arg Phe Ala Asn Ser
         235                 240                 245

 agc gac cgt aag aag cat tcg cac gtg cac act agc gac aag cca tac      939
 Ser Asp Arg Lys Lys His Ser His Val His Thr Ser Asp Lys Pro Tyr
     250                 255                 260

 acg tgc aag gtg cgg ggc tgc gac aag tgc tac acg cac ccc agc tcg      987
 Thr Cys Lys Val Arg Gly Cys Asp Lys Cys Tyr Thr His Pro Ser Ser
 265                 270                 275                 280

 ctg cgt aag cac atg aag gtg cac ggg cgc tcg ccg ccg ccc agc tct     1035
 Leu Arg Lys His Met Lys Val His Gly Arg Ser Pro Pro Pro Ser Ser
                 285                 290                 295

 ggc tac gat tcg gct aca ccg tct gcc ctc gtg tcg ccc tcg tcg gac     1083
 Gly Tyr Asp Ser Ala Thr Pro Ser Ala Leu Val Ser Pro Ser Ser Asp
             300                 305                 310

 tgc ggc cac aag tcc cag gtg gcc tcc tcg gcg gcg gtg gcg gcg cgt     1131
 Cys Gly His Lys Ser Gln Val Ala Ser Ser Ala Ala Val Ala Ala Arg
         315                 320                 325

 acc gcc gac ttg agc gaa tga tgtccaccgc gttgctcgca aggtaatct         1181
 Thr Ala Asp Leu Ser Glu 
     330





      <210> 374
      <211> 2647
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (124)..(2391)

      <220>
      <221> misc_feature
      <222> (1)...(2647)
      <223> n = a,t,c or g

      <400> 374
 tctgctattc cggagtcgac gatttcgcga ggaccagtcc atgtagctct cggaaccact     60

 gaaagctacc ccttgtcctt gaggacacct ggaaccccag ccccactgac ccaccctggc    120

 agg  atg agc ttc tca ctc acg ttc acc gag ctg gcc aac atc gcc atc     168
      Met Ser Phe Ser Leu Thr Phe Thr Glu Leu Ala Asn Ile Ala Ile
        1               5                  10                  15

 cca cag tgc ggg gtg cgg aac ttc aag gcc ctg cac ctc ctg ctg cac      216
 Pro Gln Cys Gly Val Arg Asn Phe Lys Ala Leu His Leu Leu Leu His
                  20                  25                  30

 ggc atc ttg gag cac atc cac atg gcc gag ctc aag aaa gtc ctc tca      264
 Gly Ile Leu Glu His Ile His Met Ala Glu Leu Lys Lys Val Leu Ser
              35                  40                  45

 ggc gat gag gac ttc ctg cag acc tcg cag gtg gtc atc atg ccc agg      312
 Gly Asp Glu Asp Phe Leu Gln Thr Ser Gln Val Val Ile Met Pro Arg
          50                  55                  60

 gaa gga gac gcc cag cct atc ctc aac ccc atg aag agg ctc agc aat      360
 Glu Gly Asp Ala Gln Pro Ile Leu Asn Pro Met Lys Arg Leu Ser Asn
      65                  70                  75

 gtc ttc gac cac gtg gtg agc cgc ctc gac aag ttg gag aac cag ctg      408
 Val Phe Asp His Val Val Ser Arg Leu Asp Lys Leu Glu Asn Gln Leu
  80                  85                  90                  95

 gcc ctg ctg cag gac ctg ccc tcc act gcc cag ctg ctg gaa gcc agc      456
 Ala Leu Leu Gln Asp Leu Pro Ser Thr Ala Gln Leu Leu Glu Ala Ser
                 100                 105                 110

 cag ggc act gcc cgg ccc gtc cag gac ctg tgg cat ctg atc aag ctc      504
 Gln Gly Thr Ala Arg Pro Val Gln Asp Leu Trp His Leu Ile Lys Leu
             115                 120                 125

 cgg aag atg gtg gag ggt cat gat gaa gtc atg gcc aag tca atg cag      552
 Arg Lys Met Val Glu Gly His Asp Glu Val Met Ala Lys Ser Met Gln
         130                 135                 140

 acc ctg cag gac ttg ctc act gat ctt cat gca ctc cag gtc acc atc      600
 Thr Leu Gln Asp Leu Leu Thr Asp Leu His Ala Leu Gln Val Thr Ile
     145                 150                 155

 aca gcc ctc aga aaa gaa gtg gac atg ctg aag aac atg ctt gac aag      648
 Thr Ala Leu Arg Lys Glu Val Asp Met Leu Lys Asn Met Leu Asp Lys
 160                 165                 170                 175

 gta cac cca gaa aga atg gac atc ttt gct gaa gac ttc aaa ata cag      696
 Val His Pro Glu Arg Met Asp Ile Phe Ala Glu Asp Phe Lys Ile Gln
                 180                 185                 190

 aac tgg aag atg gtt gca ctg cag cgg gaa gtg gct tct ctc cag aat      744
 Asn Trp Lys Met Val Ala Leu Gln Arg Glu Val Ala Ser Leu Gln Asn
             195                 200                 205

 aag ttt aaa acc atc ccc aaa acc gag gac atg gtg ctc tgg agt ggc      792
 Lys Phe Lys Thr Ile Pro Lys Thr Glu Asp Met Val Leu Trp Ser Gly
         210                 215                 220

 ctt cat gat gcc atg ttc acc tca gaa att ggt tca tca cca ctg gac      840
 Leu His Asp Ala Met Phe Thr Ser Glu Ile Gly Ser Ser Pro Leu Asp
     225                 230                 235

 ctg tgg cag tct gta gag cag ctc cca gag gct gcc ctg gcc cag acc      888
 Leu Trp Gln Ser Val Glu Gln Leu Pro Glu Ala Ala Leu Ala Gln Thr
 240                 245                 250                 255

 acc aag tac ctt gaa gct act cgt gcc atc cag gtc tcc gag ccc gtc      936
 Thr Lys Tyr Leu Glu Ala Thr Arg Ala Ile Gln Val Ser Glu Pro Val
                 260                 265                 270

 caa aac ccc cag cta ctg cag act gtc tgg cat tat gag gtc cca gag      984
 Gln Asn Pro Gln Leu Leu Gln Thr Val Trp His Tyr Glu Val Pro Glu
             275                 280                 285

 ctc ctc ccg gag ggc tca tct gcc caa gca gtt tca ctc agc aga gcc     1032
 Leu Leu Pro Glu Gly Ser Ser Ala Gln Ala Val Ser Leu Ser Arg Ala
         290                 295                 300

 cag gag cca gcg cag cct ccg gcc ctc acg cct gag tct gca cct ggg     1080
 Gln Glu Pro Ala Gln Pro Pro Ala Leu Thr Pro Glu Ser Ala Pro Gly
     305                 310                 315

 tgc aca act gaa ttt gca cct ggg cct gca cct ggg act gaa cct gtg     1128
 Cys Thr Thr Glu Phe Ala Pro Gly Pro Ala Pro Gly Thr Glu Pro Val
 320                 325                 330                 335

 cca gga ctg gag ctg ggg ctg gag ctg gag cct gtg cct gcc ctg ggg     1176
 Pro Gly Leu Glu Leu Gly Leu Glu Leu Glu Pro Val Pro Ala Leu Gly
                 340                 345                 350

 cct gtc cca ggg ccc agt gtg aca cct ggg tcc ttg cca gca cct tgg     1224
 Pro Val Pro Gly Pro Ser Val Thr Pro Gly Ser Leu Pro Ala Pro Trp
             355                 360                 365

 cct gtg ctt gga cct gtg cct gcc cca ggt gtc ctg cgg cca act cag     1272
 Pro Val Leu Gly Pro Val Pro Ala Pro Gly Val Leu Arg Pro Thr Gln
         370                 375                 380

 ccc caa ccc tcc agg gcc cca cca cca gcc act gag ttt ggc tca ttg     1320
 Pro Gln Pro Ser Arg Ala Pro Pro Pro Ala Thr Glu Phe Gly Ser Leu
     385                 390                 395

 ggg gct cga cca ctc cag cca tat cag tct cgc cag gga gaa gcc ctc     1368
 Gly Ala Arg Pro Leu Gln Pro Tyr Gln Ser Arg Gln Gly Glu Ala Leu
 400                 405                 410                 415

 cag ctc gca gct gtc caa gta aag ggg gag gaa aat gat gtc ccc agc     1416
 Gln Leu Ala Ala Val Gln Val Lys Gly Glu Glu Asn Asp Val Pro Ser
                 420                 425                 430

 cta agg ggc ctt cgg gag agg gcc cgc aag gat ggg gcc ccc aag gat     1464
 Leu Arg Gly Leu Arg Glu Arg Ala Arg Lys Asp Gly Ala Pro Lys Asp
             435                 440                 445

 aga act cgc aag gat ggg gtc ccc aaa gat aga ggt ggc aag gat gtg     1512
 Arg Thr Arg Lys Asp Gly Val Pro Lys Asp Arg Gly Gly Lys Asp Val
         450                 455                 460

 gac ccc aag gat aga gct cac aag gat gat gtc ccc aaa gat aga ggt     1560
 Asp Pro Lys Asp Arg Ala His Lys Asp Asp Val Pro Lys Asp Arg Gly
     465                 470                 475

 ggc aag gat gtg gac ccc aag gat aga gct cac aag gat gat gtc ccc     1608
 Gly Lys Asp Val Asp Pro Lys Asp Arg Ala His Lys Asp Asp Val Pro
 480                 485                 490                 495

 aaa gat aga ggt ggc aaa gat ggg gac ccc aag gat aga gtt ggc aag     1656
 Lys Asp Arg Gly Gly Lys Asp Gly Asp Pro Lys Asp Arg Val Gly Lys
                 500                 505                 510

 gat ggg gcc ccc aag gaa gca cag cct aag gct ccc cag tct gcc ctt     1704
 Asp Gly Ala Pro Lys Glu Ala Gln Pro Lys Ala Pro Gln Ser Ala Leu
             515                 520                 525

 cac cgg ctg aaa acc acc gct gcc atc gcc gcc gct gcc gcc gca gcc     1752
 His Arg Leu Lys Thr Thr Ala Ala Ile Ala Ala Ala Ala Ala Ala Ala
         530                 535                 540

 tac gcc gct gcc aca tcc tcc gct gcc cag gca gcc aaa gtt gct gcc     1800
 Tyr Ala Ala Ala Thr Ser Ser Ala Ala Gln Ala Ala Lys Val Ala Ala
     545                 550                 555

 aag ttt gtc aag gat gcc cca gcc acc aaa atg gcc gcc att gca aca     1848
 Lys Phe Val Lys Asp Ala Pro Ala Thr Lys Met Ala Ala Ile Ala Thr
 560                 565                 570                 575

 gac acg gct gca gct ggg ccc cta ggg gtc ttt gca gat gtc ctg ggt     1896
 Asp Thr Ala Ala Ala Gly Pro Leu Gly Val Phe Ala Asp Val Leu Gly
                 580                 585                 590

 gca ggg cct tcc cgg gga gcc aca gaa tcc cag atc ttg ggc gat gat     1944
 Ala Gly Pro Ser Arg Gly Ala Thr Glu Ser Gln Ile Leu Gly Asp Asp
             595                 600                 605

 tcc gaa atc tac gaa atc ctc tct ccc tcc tac tct gct gcc agc atc     1992
 Ser Glu Ile Tyr Glu Ile Leu Ser Pro Ser Tyr Ser Ala Ala Ser Ile
         610                 615                 620

 ggt ccc gat cca gcc ctg tcc cag gcc atg gtg gct acc aag cag gcc     2040
 Gly Pro Asp Pro Ala Leu Ser Gln Ala Met Val Ala Thr Lys Gln Ala
     625                 630                 635

 atg agc cct gaa gac aag aag agg gct gtc aag tat tcc atg agc cac     2088
 Met Ser Pro Glu Asp Lys Lys Arg Ala Val Lys Tyr Ser Met Ser His
 640                 645                 650                 655

 ata gcc cag ata cct gtc aaa cac gac tct ctg aag gaa gaa ttt gcc     2136
 Ile Ala Gln Ile Pro Val Lys His Asp Ser Leu Lys Glu Glu Phe Ala
                 660                 665                 670

 cag ctg tcc tgt aac ctg aac cag cgc ttg agt tat cta gcc aat atg     2184
 Gln Leu Ser Cys Asn Leu Asn Gln Arg Leu Ser Tyr Leu Ala Asn Met
             675                 680                 685

 gga ggt cct tcc agc ctc ggg aca aca gtg gac ata ttg cag aaa aag     2232
 Gly Gly Pro Ser Ser Leu Gly Thr Thr Val Asp Ile Leu Gln Lys Lys
         690                 695                 700

 att ggc agc ctc cag aaa tct agg ctc aag gag gaa gaa ctt gag aga     2280
 Ile Gly Ser Leu Gln Lys Ser Arg Leu Lys Glu Glu Glu Leu Glu Arg
     705                 710                 715

 att tgg ggc aac caa ata gag atg atg aag gat cgc tac atc act ttg     2328
 Ile Trp Gly Asn Gln Ile Glu Met Met Lys Asp Arg Tyr Ile Thr Leu
 720                 725                 730                 735

 gac aag gcg gtg gag aac ctg cag att cgc atg gat gag ttc aag gtt     2376
 Asp Lys Ala Val Glu Asn Leu Gln Ile Arg Met Asp Glu Phe Lys Val
                 740                 745                 750

 agg agg act ggg tag gctggagaag ggctggcaaa gggagaattc ctcacctaga     2431
 Arg Arg Thr Gly 
             755

 ccttctggcc cttcccgaag gttctgcatg aggaggggat gcacttgang ctggnaacca   2491

 ctggggcttt actggggttt tactgtgtgg aaattacact tcgatgattc ccccaccatt   2551

 ttcattatcc ccccgggggg cggtattatc agaaggggcg ggacactttt cggctttttg   2611

 acacctgcgt tccctgcccc tgaaagggga ggggag                             2647




      <210> 375
      <211> 1449
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1449)

      <400> 375
  atg agt cac tgc agc agc cgc gcc ctg acc ctg ctg agc agc gtg ttt      48
  Met Ser His Cys Ser Ser Arg Ala Leu Thr Leu Leu Ser Ser Val Phe
    1               5                  10                  15

 ggt gcg tgt ggc ctg ctc ctg gta ggc atc gcg gtc agc act gac tac       96
 Gly Ala Cys Gly Leu Leu Leu Val Gly Ile Ala Val Ser Thr Asp Tyr
              20                  25                  30

 tgg ctg tac atg gaa gaa ggc aca gtg cta ccg cag aac cag acc acc      144
 Trp Leu Tyr Met Glu Glu Gly Thr Val Leu Pro Gln Asn Gln Thr Thr
          35                  40                  45

 gag gtc aag atg gcc ctg cac gcc ggc ctc tgg cga gtc tgc ttc ttt      192
 Glu Val Lys Met Ala Leu His Ala Gly Leu Trp Arg Val Cys Phe Phe
      50                  55                  60

 gca ggt cgg gag aaa ggt cgc tgt gtg gcc tca gaa tat ttt ctt gaa      240
 Ala Gly Arg Glu Lys Gly Arg Cys Val Ala Ser Glu Tyr Phe Leu Glu
  65                  70                  75                  80

 ccg gag atc aat ttg gtg acg gaa aac acg gag aat att ctg aag aca      288
 Pro Glu Ile Asn Leu Val Thr Glu Asn Thr Glu Asn Ile Leu Lys Thr
                  85                  90                  95

 gtg cgc acg gcc acc ccc ttc ccc atg gtc agc ctc ttc ctc gtg ttc      336
 Val Arg Thr Ala Thr Pro Phe Pro Met Val Ser Leu Phe Leu Val Phe
             100                 105                 110

 acg gcc ttc gtc atc agc aac atc ggc cac atc cgc ccg cag agg acc      384
 Thr Ala Phe Val Ile Ser Asn Ile Gly His Ile Arg Pro Gln Arg Thr
         115                 120                 125

 att ctg gct ttt gtc tct ggc atc ttc ttc ata cta tcg gtc gcc act      432
 Ile Leu Ala Phe Val Ser Gly Ile Phe Phe Ile Leu Ser Val Ala Thr
     130                 135                 140

 ggc tgc ctg aga tct ttc tcc gtg gat tcc tct gct aag acc gct gcc      480
 Gly Cys Leu Arg Ser Phe Ser Val Asp Ser Ser Ala Lys Thr Ala Ala
 145                 150                 155                 160

 atg cca gtg acg gta acc cgc acc acc atc aca acc acc acg acg tca      528
 Met Pro Val Thr Val Thr Arg Thr Thr Ile Thr Thr Thr Thr Thr Ser
                 165                 170                 175

 tct tcg ggc ctg ggg tcc ccc atg atc gtg ggg tcc cct cgg gcc ctg      576
 Ser Ser Gly Leu Gly Ser Pro Met Ile Val Gly Ser Pro Arg Ala Leu
             180                 185                 190

 aca cag ccc ctg ggt ctc ctt cgc ctg ctg cag ctg gtg tct acc tgc      624
 Thr Gln Pro Leu Gly Leu Leu Arg Leu Leu Gln Leu Val Ser Thr Cys
         195                 200                 205

 gtg gcc ttc tcg ctg gtg gct agc gtg ggc gcc tgg acg ggg tcc atg      672
 Val Ala Phe Ser Leu Val Ala Ser Val Gly Ala Trp Thr Gly Ser Met
     210                 215                 220

 ggc aac tgg tcc atg ttc acc tgg tgc ttc tgc ttc tcc gtg acc ctg      720
 Gly Asn Trp Ser Met Phe Thr Trp Cys Phe Cys Phe Ser Val Thr Leu
 225                 230                 235                 240

 atc atc ctc atc gtg gag ctg tgc ggg ctc cag gcc cgc ttc ccc ctg      768
 Ile Ile Leu Ile Val Glu Leu Cys Gly Leu Gln Ala Arg Phe Pro Leu
                 245                 250                 255

 tct tgg cgc aac ttc ccc atc acc ttc gcc tgc tat gcg gcc ctc ttc      816
 Ser Trp Arg Asn Phe Pro Ile Thr Phe Ala Cys Tyr Ala Ala Leu Phe
             260                 265                 270

 tgc ctc tcg gcc tcc atc atc tac ccc acc acc tat gtc cag ttc ctg      864
 Cys Leu Ser Ala Ser Ile Ile Tyr Pro Thr Thr Tyr Val Gln Phe Leu
         275                 280                 285

 tcc cac ggc cgt tcg cgg gac cac gcc atc gcc gcc acc ttc ttc tcc      912
 Ser His Gly Arg Ser Arg Asp His Ala Ile Ala Ala Thr Phe Phe Ser
     290                 295                 300

 tgc atc gcg tgt gtg gct tac gcc acc gaa gtg gcc tgg acc cgg gcc      960
 Cys Ile Ala Cys Val Ala Tyr Ala Thr Glu Val Ala Trp Thr Arg Ala
 305                 310                 315                 320

 cgg ccc ggc gag atc act ggc tat atg gcc acc gta ccc ggg ctg ctg     1008
 Arg Pro Gly Glu Ile Thr Gly Tyr Met Ala Thr Val Pro Gly Leu Leu
                 325                 330                 335

 aag gtg ctg gag acc ttc gtt gcc tgc atc atc ttc gcg ttc atc agc     1056
 Lys Val Leu Glu Thr Phe Val Ala Cys Ile Ile Phe Ala Phe Ile Ser
             340                 345                 350

 gac ccc aac ctg tac cag cac cag ccg gcc ctg gag tgg tgc gtg gcg     1104
 Asp Pro Asn Leu Tyr Gln His Gln Pro Ala Leu Glu Trp Cys Val Ala
         355                 360                 365

 gtg tac gcc atc tgc ttc atc cta gcg gcc atc gcc atc ctg ctg aac     1152
 Val Tyr Ala Ile Cys Phe Ile Leu Ala Ala Ile Ala Ile Leu Leu Asn
     370                 375                 380

 ctg ggg gag tgc acc aac gtg cta ccc atc ccc ttc ccc agc ttc ctg     1200
 Leu Gly Glu Cys Thr Asn Val Leu Pro Ile Pro Phe Pro Ser Phe Leu
 385                 390                 395                 400

 tcg ggg ctg gcc ttg ctg tct gtc ctc ctc tat gcc acc gcc ctt gtt     1248
 Ser Gly Leu Ala Leu Leu Ser Val Leu Leu Tyr Ala Thr Ala Leu Val
                 405                 410                 415

 ctc tgg ccc ctc tac cag ttc gat gag aag tat ggc ggc cag cct cgg     1296
 Leu Trp Pro Leu Tyr Gln Phe Asp Glu Lys Tyr Gly Gly Gln Pro Arg
             420                 425                 430

 cgc tcg aga gat gta agc tgc agc cgc agc cat gcc tac tac gtg tgt     1344
 Arg Ser Arg Asp Val Ser Cys Ser Arg Ser His Ala Tyr Tyr Val Cys
         435                 440                 445

 gcc tgg gac cgc cga ctg gct gtg gcc atc ctg acg gcc atc aac cta     1392
 Ala Trp Asp Arg Arg Leu Ala Val Ala Ile Leu Thr Ala Ile Asn Leu
     450                 455                 460

 ctg gcg tat gtg gct gac ctg gtg cac tct gcc cac ctg gtt ttt gtc     1440
 Leu Ala Tyr Val Ala Asp Leu Val His Ser Ala His Leu Val Phe Val
 465                 470                 475                 480

 aag gtc taa                                                         1449
 Lys Val 






      <210> 376
      <211> 586
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(532)

      <400> 376
 acct atg acc cca acc tca ggt ggc agc acc cct ccg ggc atc act gca      49
      Met Thr Pro Thr Ser Gly Gly Ser Thr Pro Pro Gly Ile Thr Ala
        1               5                  10                  15

 cca gcc gtg cct agc atc cca tcc ccc att ggg gtg aat ggc ttc acc       97
 Pro Ala Val Pro Ser Ile Pro Ser Pro Ile Gly Val Asn Gly Phe Thr
                  20                  25                  30

 ggc ctc ccc cca cag gcc aat ggg caa cct gct gcg gaa gct gtg ttc      145
 Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro Ala Ala Glu Ala Val Phe
              35                  40                  45

 gcc aat ggc atc cac ccc tac cca gca cag agc ccc acc gcc gcg gac      193
 Ala Asn Gly Ile His Pro Tyr Pro Ala Gln Ser Pro Thr Ala Ala Asp
          50                  55                  60

 ccc ctg cag cag gcc tac gcc gga gtg cag cag tat gca ggt cca gct      241
 Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln Gln Tyr Ala Gly Pro Ala
      65                  70                  75

 gcc tac cct gct gcc tat ggt cag ata agc cag gcc ttt cct cag ccg      289
 Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser Gln Ala Phe Pro Gln Pro
  80                  85                  90                  95

 cct cca atg atc ccc cag cag cag aga gaa ggg ccc gag ggc tgt aac      337
 Pro Pro Met Ile Pro Gln Gln Gln Arg Glu Gly Pro Glu Gly Cys Asn
                 100                 105                 110

 ctg ttc atc tac cat ctg ccc cag gag ttt ggg gac gct gag ctg atg      385
 Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Ala Glu Leu Met
             115                 120                 125

 cag atg ttc ctc cct ttc ggc ttc gtg agc ttc gac aac ccg gcc agc      433
 Gln Met Phe Leu Pro Phe Gly Phe Val Ser Phe Asp Asn Pro Ala Ser
         130                 135                 140

 gcg cag acc gcc atc cag gcc atg aac ggc ttc cag atc ggc atg aag      481
 Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe Gln Ile Gly Met Lys
     145                 150                 155

 agg ctc aag gtg cag ctg aag cgg ccc aaa gac gcc aat cgc ccg tac      529
 Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp Ala Asn Arg Pro Tyr
 160                 165                 170                 175

 tga gcgc cggcgggagc gtcccccggg ggagaccagg actcgcacag ggcaggatgc      586
 






      <210> 377
      <211> 1250
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (5)..(592)

      <400> 377
 acct atg acc cca acc tca ggt ggc agc acc cct ccg ggc atc act gca      49
      Met Thr Pro Thr Ser Gly Gly Ser Thr Pro Pro Gly Ile Thr Ala
        1               5                  10                  15

 cca gcc gtg cct agc atc cca tcc ccc att ggg gtg aat ggc ttc acc       97
 Pro Ala Val Pro Ser Ile Pro Ser Pro Ile Gly Val Asn Gly Phe Thr
                  20                  25                  30

 ggc ctc ccc cca cag gcc aat ggg caa cct gct gcg gaa gct gtg ttc      145
 Gly Leu Pro Pro Gln Ala Asn Gly Gln Pro Ala Ala Glu Ala Val Phe
              35                  40                  45

 gcc aat ggc atc cac ccc tac cca gca cag agc ccc acc gcc gcg gac      193
 Ala Asn Gly Ile His Pro Tyr Pro Ala Gln Ser Pro Thr Ala Ala Asp
          50                  55                  60

 ccc ctg cag cag gcc tac gcc gga gtg cag cag tat gca ggt cca gct      241
 Pro Leu Gln Gln Ala Tyr Ala Gly Val Gln Gln Tyr Ala Gly Pro Ala
      65                  70                  75

 gcc tac cct gct gcc tat ggt cag ata agc cag gcc ttt cct cag ccg      289
 Ala Tyr Pro Ala Ala Tyr Gly Gln Ile Ser Gln Ala Phe Pro Gln Pro
  80                  85                  90                  95

 cct cca atg atc ccc cag cag cag aga gaa ggg ccc gag ggc tgt aac      337
 Pro Pro Met Ile Pro Gln Gln Gln Arg Glu Gly Pro Glu Gly Cys Asn
                 100                 105                 110

 ctg ttc atc tac cat ctg ccc cag gag ttt ggg gac gct gag ctg atg      385
 Leu Phe Ile Tyr His Leu Pro Gln Glu Phe Gly Asp Ala Glu Leu Met
             115                 120                 125

 cag atg ttc ctc cct ttc ggt aat gtc atc tcc tcg aaa gtg ttt gtg      433
 Gln Met Phe Leu Pro Phe Gly Asn Val Ile Ser Ser Lys Val Phe Val
         130                 135                 140

 gat cgg gcg act aac caa agt aaa tgc ttt ggc ttc gtg agc ttc gac      481
 Asp Arg Ala Thr Asn Gln Ser Lys Cys Phe Gly Phe Val Ser Phe Asp
     145                 150                 155

 aac ccg gcc agc gcg cag acc gcc atc cag gcc atg aac ggc ttc cag      529
 Asn Pro Ala Ser Ala Gln Thr Ala Ile Gln Ala Met Asn Gly Phe Gln
 160                 165                 170                 175

 atc ggc atg aag agg ctc aag gtg cag ctg aag cgg ccc aaa gac gcc      577
 Ile Gly Met Lys Arg Leu Lys Val Gln Leu Lys Arg Pro Lys Asp Ala
                 180                 185                 190

 aat cgc ccg tac tga gcgccggcgg gagcgtcccc cgggggagac caggactcgc      632
 Asn Arg Pro Tyr 
             195

 acagggcagg atgctgaacg ggctacatta aaaaacaaac ctctctctat atatatttat    692

 aaatgagaac tgttggatga cacctttgac atatcagcca atatcaatca agctgaagac    752

 tccagacact gtctgtgtga ctgtaacatt tcttcaagga aagtatagcg tctatggagt    812

 tcagagggca cgtgtttggg ggaaaatata tatgacatga agaagaagat gaagaaaaat    872

 gagaaaaaaa cacacaaaag gcaactttaa aacaaaatat cacgagcaga cggggaggct    932

 gaagggctgg gagctgggag gagacgctgc ttaccgatcc cggggctttt ccagcccacg    992

 ggcgcctgac gcaggctggg gcaagtggtg cgtggggcct ggtccccaag gggcggctga   1052

 gaggccgcca ctgagcatct ctatctgtca ttcctttagc tatttaggga ccaaaggacc   1112

 aaacttttta ttgcagatgt gtagctctat gtcaaataga gggggaatgg aggaccccct   1172

 ccttcctgcc tcatggctgt tcttgaaaca gcttagagcg attctatgaa aaaatgtaat   1232

 aaaaaattaa aaaaaaaa                                                 1250




      <210> 378
      <211> 1298
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (460)..(1248)

      <220>
      <221> misc_feature
      <222> (1)...(1298)
      <223> n = a,t,c or g

      <400> 378
 aggcgcattt aacccagaac cctgccaagc tttatccaag aggcatgttc ccatttgggc     60

 cttataggaa atttccgtcc cacgaaaggc aggattacca ccttttgttt tttttttagc    120

 agtttgagtt ggtgtagtgt atcctgggtt atcagaatac tcatatagct ttgggatttt    180

 gacttggtaa atattcatga tgtgtgaaaa atcatgatac atactgtaca gtctcagtcc    240

 cgtaaaactg gatgtagtgc ctacacacag gatctagaag aatatgtcaa actataaact    300

 gcttgtgatt gtgaatgact ttgttctttg cttgtgtttt tcaatttcct ataatgcaca    360

 tactaaccgc cgggccgctt gacgacgacg ctcccgcggg ggccccgcca aaaaaganac    420

 cgtccgaatt cggcacgagg ccgcgggagg ccgcggagg   atg gag gag cgg aag     474
                                              Met Glu Glu Arg Lys
                                                1               5

 gag gag ggc gag gcc gag atc cag gag cac ggg ccc gag cac tgg ttc      522
 Glu Glu Gly Glu Ala Glu Ile Gln Glu His Gly Pro Glu His Trp Phe
                  10                  15                  20

 tcc aag tgg gag cgg cag tgc ctg gcc gag gcc gaa cag gac gag cag      570
 Ser Lys Trp Glu Arg Gln Cys Leu Ala Glu Ala Glu Gln Asp Glu Gln
              25                  30                  35

 ctg ccc ccc gag ctg cag gag gag gcg gct gca gag ttg gca ggg ctc      618
 Leu Pro Pro Glu Leu Gln Glu Glu Ala Ala Ala Glu Leu Ala Gly Leu
          40                  45                  50

 aag agc gag aag cag aag ctg tgg cac ctc ttc cag atc tcg gcc acc      666
 Lys Ser Glu Lys Gln Lys Leu Trp His Leu Phe Gln Ile Ser Ala Thr
      55                  60                  65

 gcc gtt gct cag ctt tac aag gat tct ggg tgc caa cag caa gga ctt      714
 Ala Val Ala Gln Leu Tyr Lys Asp Ser Gly Cys Gln Gln Gln Gly Leu
  70                  75                  80                  85

 tcc atg tgg gac ccc ttc cag aat gcg gcc atg gcc gtg acc agc ctc      762
 Ser Met Trp Asp Pro Phe Gln Asn Ala Ala Met Ala Val Thr Ser Leu
                  90                  95                 100

 tac aaa gag agc ggg gat gcc cac caa cga agt ttt gac ttg ggt gtc      810
 Tyr Lys Glu Ser Gly Asp Ala His Gln Arg Ser Phe Asp Leu Gly Val
             105                 110                 115

 cag gtt ggc cac cag cgt cgc atc aaa gat gtg ctg gag tgg gtg aaa      858
 Gln Val Gly His Gln Arg Arg Ile Lys Asp Val Leu Glu Trp Val Lys
         120                 125                 130

 aag ggc cgg agc acc att cgt cgc gaa gac ttg att agc ttc ctg tgt      906
 Lys Gly Arg Ser Thr Ile Arg Arg Glu Asp Leu Ile Ser Phe Leu Cys
     135                 140                 145

 ggc aaa gtg ccc ccc gct cct cct cca cct cgc act cct agg aca ccc      954
 Gly Lys Val Pro Pro Ala Pro Pro Pro Pro Arg Thr Pro Arg Thr Pro
 150                 155                 160                 165

 ccg aag cca ccc act ggg gtc acc agc cag gct gtg gca act gag tcc     1002
 Pro Lys Pro Pro Thr Gly Val Thr Ser Gln Ala Val Ala Thr Glu Ser
                 170                 175                 180

 agc tca tcg gtg gac gtc gac ctg cag ccc ttc cag gag gcg atc gcc     1050
 Ser Ser Ser Val Asp Val Asp Leu Gln Pro Phe Gln Glu Ala Ile Ala
             185                 190                 195

 ctg cat ggc ctc agt ggt gct atg gcc ggc atc agc atg cga tcg ggc     1098
 Leu His Gly Leu Ser Gly Ala Met Ala Gly Ile Ser Met Arg Ser Gly
         200                 205                 210

 gac tcg cct caa gac agc ggt gtc gcc agc agt ggg cgc cga aaa act     1146
 Asp Ser Pro Gln Asp Ser Gly Val Ala Ser Ser Gly Arg Arg Lys Thr
     215                 220                 225

 agc ttc ttg gag gac gac ttg aat ccc ttc gac tca gag gaa ctg gcc     1194
 Ser Phe Leu Glu Asp Asp Leu Asn Pro Phe Asp Ser Glu Glu Leu Ala
 230                 235                 240                 245

 ctc cac ctg gac agt ggg ggg atc ccg caa gcg cac ctc ggc cca atg     1242
 Leu His Leu Asp Ser Gly Gly Ile Pro Gln Ala His Leu Gly Pro Met
                 250                 255                 260

 cag tga tggcatcaca gactccccaa tccaaaagcg caaccgaatg gtctaaactg      1298
 Gln 






      <210> 379
      <211> 1211
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (880)..(1200)

      <400> 379
 aaattttatt ataaagacct ttattaggag aaaggacata ttttctattt cttactttta     60

 ttttgtgcct tgaaggactt gtgaatgtat agaataatta ttttttctta ctgcttcctc    120

 tttgcaaccc aacctccacc aagtcaatcg tgaaggtagg aagaaagctg tatttctgtt    180

 acttttaaaa atgataacga gaagaaatta aaacaatggc ttaagagaaa gaggatgtaa    240

 ggagtacaaa gcaaaactta acaaagagtt agtaaaggaa cttgcattga caattcactc    300

 agccatgtta attttatcat taatactgtc ttcatcattt ttttttccag gtctctctgc    360

 tcgtatttgc ttggtgctcc gaaatgcacg ggaacagaca gctatgggaa agctgcacag    420

 agcagttggc aatcaacatg tcctagaagg gtgtgtggag tagcaaaaca agtggaacgg    480

 atgaagaact tccaagctcc ttcgcagagt tttgggccct agtgtgcagg gctgctccct    540

 catgagatgg aggaaaatgt cgcccacacc tacttggacc tctcaccaag gacactgccc    600

 tcagagataa atctgttgga cggcagccaa gagaccccaa attgtctcaa cctccaggac    660

 acggcaagtt gcaagtttcc gagttgggga ggcaaagcgg gaaaacatgt ttggcgattt    720

 cctcctgcca ctcaccgacc ggagaaatgg ggaggcggac tccaggtctt tcgtggactg    780

 ccaagagccc tatagggcgt ccagctataa aaagagaaga atcccatgaa ggacaacaag    840

 caaactcata tgttatccct ttagccggat tgtgtgctg   atg att gtt tcc cta     894
                                              Met Ile Val Ser Leu
                                                1               5

 ttt aca ctt cga atc acc cct gtg gtc ttt tgt gag tcc cca agg cag      942
 Phe Thr Leu Arg Ile Thr Pro Val Val Phe Cys Glu Ser Pro Arg Gln
                  10                  15                  20

 cct cag cct tcg caa acc gtc cag tgg ggc acg aat ctc gga ggg gtg      990
 Pro Gln Pro Ser Gln Thr Val Gln Trp Gly Thr Asn Leu Gly Gly Val
              25                  30                  35

 cgg gct gca ggc ggc aga ggg aag cca aag agg ggc ggc ttt tcc agg     1038
 Arg Ala Ala Gly Gly Arg Gly Lys Pro Lys Arg Gly Gly Phe Ser Arg
          40                  45                  50

 ccg tcc acc ccc agg cga gct ggt cct cac cct tcg atc ggc tcg agt     1086
 Pro Ser Thr Pro Arg Arg Ala Gly Pro His Pro Ser Ile Gly Ser Ser
      55                  60                  65

 ccc tcg gac agt tgc cca ctc aca gcg tgc aaa ggg gtc gca ctc cct     1134
 Pro Ser Asp Ser Cys Pro Leu Thr Ala Cys Lys Gly Val Ala Leu Pro
  70                  75                  80                  85

 gtg ggt tct ccg ccc tca gaa gcc gcg ctg cgc agg aaa gtc acc tcc     1182
 Val Gly Ser Pro Pro Ser Glu Ala Ala Leu Arg Arg Lys Val Thr Ser
                  90                  95                 100

 act acg ggc cgg gag tag ggaggggagc c                                1211
 Thr Thr Gly Arg Glu 
             105





      <210> 380
      <211> 1706
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (92)..(1309)

      <400> 380
 gtggctgctg tccaccctgc tggccacccc agagcctact gcctccctgc tggggaacct     60

 cagacccccc tcactccttc agggggaggt g   atg ggg acc cct tcc tca ccc     112
                                      Met Gly Thr Pro Ser Ser Pro
                                        1               5

 agg ggc cct gag tcc ccc cga ctg gca gca ggg ccc tct ccc tgc tgg      160
 Arg Gly Pro Glu Ser Pro Arg Leu Ala Ala Gly Pro Ser Pro Cys Trp
          10                  15                  20

 cac ctg gga gcc atg cat gaa tca agg agt cgc tgg aca gag cct ggg      208
 His Leu Gly Ala Met His Glu Ser Arg Ser Arg Trp Thr Glu Pro Gly
      25                  30                  35

 tgt tcc cag tgc tgg tgc gag gac ggg aag gtg acc tgt gaa aag gtg      256
 Cys Ser Gln Cys Trp Cys Glu Asp Gly Lys Val Thr Cys Glu Lys Val
  40                  45                  50                  55

 agg tgt gaa gct gct tgt tcc cac cca att ccc tcc aga gat ggt ggg      304
 Arg Cys Glu Ala Ala Cys Ser His Pro Ile Pro Ser Arg Asp Gly Gly
                  60                  65                  70

 tgc tgc cca tcg tgc aca ggc tgt ttt cac agt ggt gtc gtc cga gct      352
 Cys Cys Pro Ser Cys Thr Gly Cys Phe His Ser Gly Val Val Arg Ala
              75                  80                  85

 gaa ggg gat gtg ttt tca cct ccc aat gag aac tgc acc gtc tgt gtc      400
 Glu Gly Asp Val Phe Ser Pro Pro Asn Glu Asn Cys Thr Val Cys Val
          90                  95                 100

 tgc ctg ctg ggc tca gtg gcc tgt tcc ccc gtg gac tgc ccc atc acc      448
 Cys Leu Leu Gly Ser Val Ala Cys Ser Pro Val Asp Cys Pro Ile Thr
     105                 110                 115

 tgt acc tac cct ttc cac cct gac ggg gag tgc tgc ccc gtg tgc cga      496
 Cys Thr Tyr Pro Phe His Pro Asp Gly Glu Cys Cys Pro Val Cys Arg
 120                 125                 130                 135

 gac tgc aac tac gag gga agg aag gtg gcg aat ggc cag gtg ttc acc      544
 Asp Cys Asn Tyr Glu Gly Arg Lys Val Ala Asn Gly Gln Val Phe Thr
                 140                 145                 150

 ttg gat gat gaa ccc tgc acc cgg tgc acg tgc cag ctg gga gag gtg      592
 Leu Asp Asp Glu Pro Cys Thr Arg Cys Thr Cys Gln Leu Gly Glu Val
             155                 160                 165

 agc tgt gag aag gtt ccc tgc cag cgg gcc tgt gcc gac cct gcc ctg      640
 Ser Cys Glu Lys Val Pro Cys Gln Arg Ala Cys Ala Asp Pro Ala Leu
         170                 175                 180

 ctt cct ggg gac tgc tgc tct tcc tgt cca gat tcc ctg tct cct ctg      688
 Leu Pro Gly Asp Cys Cys Ser Ser Cys Pro Asp Ser Leu Ser Pro Leu
     185                 190                 195

 gaa gaa aag cag ggg ctc tcc cct cac gga aat gtg gca ttc agc aaa      736
 Glu Glu Lys Gln Gly Leu Ser Pro His Gly Asn Val Ala Phe Ser Lys
 200                 205                 210                 215

 gct ggt cgg agc ctg cat gga gac act gag gcc cct gtc aac tgt agc      784
 Ala Gly Arg Ser Leu His Gly Asp Thr Glu Ala Pro Val Asn Cys Ser
                 220                 225                 230

 tcc tgt cct ggg ccc ccg aca gca tca ccc tcg agg ccg gtg ctt cat      832
 Ser Cys Pro Gly Pro Pro Thr Ala Ser Pro Ser Arg Pro Val Leu His
             235                 240                 245

 ctc ctc cag ctc ctt tta aga acg aac ttg atg aaa aca cag act tta      880
 Leu Leu Gln Leu Leu Leu Arg Thr Asn Leu Met Lys Thr Gln Thr Leu
         250                 255                 260

 cct aca agc ccg gca gga gct cat ggt cca cac tca ctc gct ttg ggg      928
 Pro Thr Ser Pro Ala Gly Ala His Gly Pro His Ser Leu Ala Leu Gly
     265                 270                 275

 ctg aca gcc act ttc cca ggg gag cct ggg gcc tcc cct cga ctc tca      976
 Leu Thr Ala Thr Phe Pro Gly Glu Pro Gly Ala Ser Pro Arg Leu Ser
 280                 285                 290                 295

 cca ggg cct tcg acc cct cca gga gcc ccc act cta cct cta gct tcc     1024
 Pro Gly Pro Ser Thr Pro Pro Gly Ala Pro Thr Leu Pro Leu Ala Ser
                 300                 305                 310

 cca ggg gct cct cag cca cct cct gtg act cca gag cgc tcg ttc tca     1072
 Pro Gly Ala Pro Gln Pro Pro Pro Val Thr Pro Glu Arg Ser Phe Ser
             315                 320                 325

 gcc tct ggg gcc cag ata gtg tcc agg tgg cct cct ctg cct ggc acc     1120
 Ala Ser Gly Ala Gln Ile Val Ser Arg Trp Pro Pro Leu Pro Gly Thr
         330                 335                 340

 ctc ctg acg gaa gct tca gca ctt tcc atg atg gac ccc agc ccc tcg     1168
 Leu Leu Thr Glu Ala Ser Ala Leu Ser Met Met Asp Pro Ser Pro Ser
     345                 350                 355

 aag acc ccc atc acc ctc ctc ggg cct cgc gtg ctt tct ccc acc acc     1216
 Lys Thr Pro Ile Thr Leu Leu Gly Pro Arg Val Leu Ser Pro Thr Thr
 360                 365                 370                 375

 tct aga ctc tcc aca gcc ctt gca gcc acc acc cac cct ggc ccc cag     1264
 Ser Arg Leu Ser Thr Ala Leu Ala Ala Thr Thr His Pro Gly Pro Gln
                 380                 385                 390

 cag ccc cca gtg ggg gct tct cgg ggg gaa gag tcc acc atg taa gga     1312
 Gln Pro Pro Val Gly Ala Ser Arg Gly Glu Glu Ser Thr Met 
             395                 400                 405

 ggtcactgtg tccgggagac tctggagaga ggacctctgc cagtggccca gggtgtgtgc   1372

 agggcagctc caaggatgaa cctggtgggg atgcctgggc tccctcctgc aggggccctg   1432

 gtgaggatgg aagaccccca aggctggatg taaccttgtt cccaagaagt gtttggaatg   1492

 tgctgtaaga atggaggaag tcgtttccac tgtcagcatc ctccctggac cgcgtggctg   1552

 gctcatcttt tgagaagggt tgggactgcc aagttctcct ggaggaagag ttgcgtccgg   1612

 ctgggattcc actcactggg actgtaccgc caggtgtcat gcgtctctct gaggtttcct   1672

 gattaaaggt tgtctcggtt tcaaaaaaaa aaaa                               1706




      <210> 381
      <211> 1144
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (187)..(594)

      <400> 381
 ttaaaactca acaataacaa caacagtaaa acaaacaact cgattgaaaa aataatcaaa     60

 agatctggac acctcatcaa agaagattgg gaaaaggact tctaaaagat aaatctgttt    120

 ggaaggctgt tttccaacgc cacttttgat ggctgtaagt gggatctctg gaaccaaagg    180

 gagcac   atg gct ctt ctt aaa act gaa ggt att tgt gtc caa gat gaa     228
          Met Ala Leu Leu Lys Thr Glu Gly Ile Cys Val Gln Asp Glu
            1               5                  10

 act gaa ttc tgt ttg gcc aag aga tgt gct tct gtg tac gaa gga aag      276
 Thr Glu Phe Cys Leu Ala Lys Arg Cys Ala Ser Val Tyr Glu Gly Lys
  15                  20                  25                  30

 aac aca gtg gct ttt gcc agc aaa cct aaa caa aac cag agt aat ctg      324
 Asn Thr Val Ala Phe Ala Ser Lys Pro Lys Gln Asn Gln Ser Asn Leu
                  35                  40                  45

 gaa aag gta act tgt gcc cat gaa aaa agt gac atc gtt cat aat aaa      372
 Glu Lys Val Thr Cys Ala His Glu Lys Ser Asp Ile Val His Asn Lys
              50                  55                  60

 ttc caa aac aac ttt cct gct aag gcc att gaa cac aaa atc aat gtg      420
 Phe Gln Asn Asn Phe Pro Ala Lys Ala Ile Glu His Lys Ile Asn Val
          65                  70                  75

 ata ctt tta ggc ccg agc ggg cgg gaa ggg atc tct cta gga gct gac      468
 Ile Leu Leu Gly Pro Ser Gly Arg Glu Gly Ile Ser Leu Gly Ala Asp
      80                  85                  90

 act cga acc ttc acg acc cat tcg gat ttt tcc agg act cag gag tgg      516
 Thr Arg Thr Phe Thr Thr His Ser Asp Phe Ser Arg Thr Gln Glu Trp
  95                 100                 105                 110

 cac tgg gaa gaa ggg gac cgc ttt ctg caa ttg gcc tcg aca ctg gct      564
 His Trp Glu Glu Gly Asp Arg Phe Leu Gln Leu Ala Ser Thr Leu Ala
                 115                 120                 125

 gcc aag aag acc tgt cgc ctt tgt ttt taa g tctccagaaa tggaagaaga      615
 Ala Lys Lys Thr Cys Arg Leu Cys Phe 
             130                 135

 aggcgaagtc agttgaagtc acgagaaatc agcgaggcat ttgaaggcgc ttcctgaaaa    675

 cctttattcc ctggcacgtt gtctgtttca acagccctgc ccctcctcgg agcctgcttg    735

 tggaattctt ccccttcggg tgtgtggtgg cattccccgc cacgtccaat gtggactcca    795

 aaggatttgt cccttctttg tcatttgaaa tgaaatgatg gccacgcgtc ggactggtct    855

 gtctgaggga gatagtgaca agctcaaggc gtgcgaggtc tctcaaaata aagatgtggg    915

 agaacaaagt tgttacagtg tcactagtct gcagaagggg acaatacttc tccgggagga    975

 ggtcccaaca aaagtttttg ttttaaaaga actcctcagg gtttgggttt tcaataaaag   1035

 cattttgttg gttatccccc ggagtcttgg aattcaattt ttccattagg ggtgaaaaaa   1095

 atgtaacacg gggggggaaa caaagaaacc gtttgaaccc atgggaacc               1144




      <210> 382
      <211> 975
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (259)..(855)

      <400> 382
 acatgcatgc attgtattag tgttagaaaa cacagctgcg taaataaaca gcacgggtga     60

 cccgcattcc cgctcggaca ctcgcgcgca gccccgcggc cgtccctcct cgctgcggcc    120

 cgcggtgtcc tcggggtgcg agctgcacgt ggacgcaggg ccccctcagg ccgccagggg    180

 gcggcatagc gcagcgcgcc cccgacccgg aagacggaag cccaagaacg ccgcttccgc    240

 ccggcgccca cttccaag  atg gcg gcg ggg cgg ggc cgg ggc agg gcc ggg     291
                      Met Ala Ala Gly Arg Gly Arg Gly Arg Ala Gly
                        1               5                  10

 gca ggg cgg acg gag ccg gcg agc ggg atg ctg cgg act gcg ctg cgc      339
 Ala Gly Arg Thr Glu Pro Ala Ser Gly Met Leu Arg Thr Ala Leu Arg
              15                  20                  25

 ggc gcg ccg agg ttg ctg agt cgc gtg cag ccc cgg gcg ccc tgc ctg      387
 Gly Ala Pro Arg Leu Leu Ser Arg Val Gln Pro Arg Ala Pro Cys Leu
          30                  35                  40

 agg cgg ctg tgg ggc cgc ggg gcc cgt cca gag gtc gcg ggg agg cgg      435
 Arg Arg Leu Trp Gly Arg Gly Ala Arg Pro Glu Val Ala Gly Arg Arg
      45                  50                  55

 cgg gcc tgg gcc tgg ggc tgg cgg cgc tca agc tcc gag cag ggg ccg      483
 Arg Ala Trp Ala Trp Gly Trp Arg Arg Ser Ser Ser Glu Gln Gly Pro
  60                  65                  70                  75

 ggg ccc gcg gcg gct ctg ggg cgc gtg gag gcg gcg cac tac cag ctc      531
 Gly Pro Ala Ala Ala Leu Gly Arg Val Glu Ala Ala His Tyr Gln Leu
                  80                  85                  90

 gtc tac acc tgc aag gtc tgc ggg act agg tcc tcc aag cgc atc tcc      579
 Val Tyr Thr Cys Lys Val Cys Gly Thr Arg Ser Ser Lys Arg Ile Ser
              95                 100                 105

 aag ctg gcc tat cac caa ggc gtg gtc att gtg acc tgc ccc ggc tgc      627
 Lys Leu Ala Tyr His Gln Gly Val Val Ile Val Thr Cys Pro Gly Cys
         110                 115                 120

 cag aac cac cat atc atc gct gac aac ctg ggc tgg ttc tcg gac ctg      675
 Gln Asn His His Ile Ile Ala Asp Asn Leu Gly Trp Phe Ser Asp Leu
     125                 130                 135

 aat ggg aag aga aat atc gaa gag atc ctg acg gcc aga ggc gag cag      723
 Asn Gly Lys Arg Asn Ile Glu Glu Ile Leu Thr Ala Arg Gly Glu Gln
 140                 145                 150                 155

 gtg cac cgt gtg gcg ggc gag ggg gcc ctg gaa ctg gtt ctg gag gct      771
 Val His Arg Val Ala Gly Glu Gly Ala Leu Glu Leu Val Leu Glu Ala
                 160                 165                 170

 gca ggg gcc ccc aca tcc act gca gct ccg gaa gcg ggt gag gat gag      819
 Ala Gly Ala Pro Thr Ser Thr Ala Ala Pro Glu Ala Gly Glu Asp Glu
             175                 180                 185

 ggt ccc ccc agc cct ggc aag acg gag ccg agc tga ctcc tgcgctcccc      869
 Gly Pro Pro Ser Pro Gly Lys Thr Glu Pro Ser 
         190                 195

 ggcactgtgg gacttcggcc ttccagaagg aggttttggc cctgggcctc tctggacgtg    929

 gcctgttttc tatcaataaa cagacattac ttccaaaaaa aaaaaa                   975




      <210> 383
      <211> 1035
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (423)..(989)

      <400> 383
 tagatctgac gcccctcccc ccatacacta gttttctagt tactcctgta ggtggcggag     60

 cgggcaggaa ggcgctttcg caattgaacc gtctgcatgc ccgagggttg ggtggtttcg    120

 gcctcctctt ctgttccccc tcgtgtctct cctcccacct tgtccccact cccgctagcc    180

 cgctgcctgc cgagggtata agactccccc ctcccttgat ttatctggtt acgtgtaatc    240

 gaggcgtgtt ttacgcgcat ctctttgcaa gtgggaagtc ggcactggag cacacaacag    300

 tggcatgggt cgagggtgtc ccagggcccc tcgcggttct ccctcctttc ctcccggcct    360

 gctccccttc ccattgcccc tgacacctgc acttcctggt ctccccgcag ggtggcggcg    420

 gc   atg gag gcg cgc ttc acg cgc ggg aag tcg gcg ctg ctg gag cgc     467
      Met Glu Ala Arg Phe Thr Arg Gly Lys Ser Ala Leu Leu Glu Arg
        1               5                  10                  15

 gcg ctg gcg cgg ccg cgc acc gag gtg agc ctg agc gcc ttc gca ctg      515
 Ala Leu Ala Arg Pro Arg Thr Glu Val Ser Leu Ser Ala Phe Ala Leu
                  20                  25                  30

 ctg ttc tcc gag ctg gta cag cac tgc cag agc cgc gtc ttc tcc gtg      563
 Leu Phe Ser Glu Leu Val Gln His Cys Gln Ser Arg Val Phe Ser Val
              35                  40                  45

 gcc gag ctg cag tcg cgc ctg gcc gcg ctg ggc cgc cag gtg ggc gcg      611
 Ala Glu Leu Gln Ser Arg Leu Ala Ala Leu Gly Arg Gln Val Gly Ala
          50                  55                  60

 cgc gtg ctg gat gcg ctg gtg gcg cgc gaa aag ggt gcc cgg cgt gag      659
 Arg Val Leu Asp Ala Leu Val Ala Arg Glu Lys Gly Ala Arg Arg Glu
      65                  70                  75

 acc aag gtg cta ggc gcg ttg ctc ttc gtc aag ggc gcc gtg tgg aag      707
 Thr Lys Val Leu Gly Ala Leu Leu Phe Val Lys Gly Ala Val Trp Lys
  80                  85                  90                  95

 gcg ctc ttc ggc aag gag gcg gac aag ctg gag cag gcc aac gat gac      755
 Ala Leu Phe Gly Lys Glu Ala Asp Lys Leu Glu Gln Ala Asn Asp Asp
                 100                 105                 110

 gcg cgc acc ttc tac atc atc gag cgc gag ccg ctc atc aac acc tac      803
 Ala Arg Thr Phe Tyr Ile Ile Glu Arg Glu Pro Leu Ile Asn Thr Tyr
             115                 120                 125

 atc tcc gtg ccc aag gag aac agc acg ctc aac tgc gcc agc ttc acg      851
 Ile Ser Val Pro Lys Glu Asn Ser Thr Leu Asn Cys Ala Ser Phe Thr
         130                 135                 140

 gcg ggc atc gtg gag gcg gtg ctc aca cac agc ggc ttc cct gcc aag      899
 Ala Gly Ile Val Glu Ala Val Leu Thr His Ser Gly Phe Pro Ala Lys
     145                 150                 155

 gtc acg gcg cac tgg cac aag ggc acc acg ctc atg atc aag ttc gag      947
 Val Thr Ala His Trp His Lys Gly Thr Thr Leu Met Ile Lys Phe Glu
 160                 165                 170                 175

 gag gca gtc atc gct cga gac cgg gcc ctg gag ggc cgc tga ccctgcc      996
 Glu Ala Val Ile Ala Arg Asp Arg Ala Leu Glu Gly Arg 
                 180                 185

 ggagataaag gatacagaga gcccctcaaa aaaaaaaaa                          1035




      <210> 384
      <211> 1111
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (76)..(1089)

      <400> 384
 ggctcgcgct cgagctgcgg cgccggctcc tgccgcctgg gccccgggcc cggcccctcc     60

 cgcgccgccc gggcg atg aga agc tgc ttc tgc gtg aga cgg agc cgg gac     111
                  Met Arg Ser Cys Phe Cys Val Arg Arg Ser Arg Asp
                    1               5                  10

 ccg ccg ccg ccg cag cca ccg ccg ccg ccg ccc cag cgg gga aca gac      159
 Pro Pro Pro Pro Gln Pro Pro Pro Pro Pro Pro Gln Arg Gly Thr Asp
          15                  20                  25

 cag tcc acc atg cct gaa gtc aaa gac ctc tca gaa gcc ttg cca gaa      207
 Gln Ser Thr Met Pro Glu Val Lys Asp Leu Ser Glu Ala Leu Pro Glu
      30                  35                  40

 acg tca atg gat ccc atc acg gga gtc ggg gtg gtg gct tct cgg aac      255
 Thr Ser Met Asp Pro Ile Thr Gly Val Gly Val Val Ala Ser Arg Asn
  45                  50                  55                  60

 cga gcc ccg aca ggc tat gac gta gtt gca cag aca gca gat ggt gtg      303
 Arg Ala Pro Thr Gly Tyr Asp Val Val Ala Gln Thr Ala Asp Gly Val
                  65                  70                  75

 gat gct gac ctc tgg aaa gac ggc tta ttt aaa tcc aag gtt acc aga      351
 Asp Ala Asp Leu Trp Lys Asp Gly Leu Phe Lys Ser Lys Val Thr Arg
              80                  85                  90

 tac ctg tgt ttc aca aga tca ttt tcc aaa gaa aat agt cat ctg ggg      399
 Tyr Leu Cys Phe Thr Arg Ser Phe Ser Lys Glu Asn Ser His Leu Gly
          95                 100                 105

 aac gtg tta gta gat atg aag ctc att gac atc aag gac aca ctg cct      447
 Asn Val Leu Val Asp Met Lys Leu Ile Asp Ile Lys Asp Thr Leu Pro
     110                 115                 120

 gtg ggc ttc atc cca att cag gag acg gtg gac aca cag gaa gtg gct      495
 Val Gly Phe Ile Pro Ile Gln Glu Thr Val Asp Thr Gln Glu Val Ala
 125                 130                 135                 140

 ttt agg aag aag agg ctg tgc att aaa ttt att cca cgg gat tca acg      543
 Phe Arg Lys Lys Arg Leu Cys Ile Lys Phe Ile Pro Arg Asp Ser Thr
                 145                 150                 155

 gaa gct gcg att tgt gac att cgg atc atg ggc cgg acc aag cag gcc      591
 Glu Ala Ala Ile Cys Asp Ile Arg Ile Met Gly Arg Thr Lys Gln Ala
             160                 165                 170

 ccg cct cag tac acg ttt att ggg gaa ctg aac agc atg ggg atc tgg      639
 Pro Pro Gln Tyr Thr Phe Ile Gly Glu Leu Asn Ser Met Gly Ile Trp
         175                 180                 185

 tat cga atg ggc aga gta cca aga aat cat gac tca tct caa ccc aca      687
 Tyr Arg Met Gly Arg Val Pro Arg Asn His Asp Ser Ser Gln Pro Thr
     190                 195                 200

 acg cct tcc cag tca tca gct gcc tcc acc cca gcc ccc aac ctt ccc      735
 Thr Pro Ser Gln Ser Ser Ala Ala Ser Thr Pro Ala Pro Asn Leu Pro
 205                 210                 215                 220

 agg cac atc tcc cta aca ctt cct gcc acc ttc cga ggc agg aac agc      783
 Arg His Ile Ser Leu Thr Leu Pro Ala Thr Phe Arg Gly Arg Asn Ser
                 225                 230                 235

 acc cgg acg gac tac gag tac cag cac tcc aat ttg tat gcc ata tca      831
 Thr Arg Thr Asp Tyr Glu Tyr Gln His Ser Asn Leu Tyr Ala Ile Ser
             240                 245                 250

 gct ctt ccc aga agc cct ccc tgg cag ctc ctg tcc tcc tct gct gga      879
 Ala Leu Pro Arg Ser Pro Pro Trp Gln Leu Leu Ser Ser Ser Ala Gly
         255                 260                 265

 tcc tgt gag cac cac agc ctc ctg tac acc ctg agc tat gcc tct caa      927
 Ser Cys Glu His His Ser Leu Leu Tyr Thr Leu Ser Tyr Ala Ser Gln
     270                 275                 280

 ggc cct cca cca gct cat ccc ctg ctg tgg gca caa gcc ctg ctt tca      975
 Gly Pro Pro Pro Ala His Pro Leu Leu Trp Ala Gln Ala Leu Leu Ser
 285                 290                 295                 300

 gag ttt ccc tgc cca ggg aat gaa tgc ccc ttg aga gac cac aca tat     1023
 Glu Phe Pro Cys Pro Gly Asn Glu Cys Pro Leu Arg Asp His Thr Tyr
                 305                 310                 315

 gct gca agt cca gcc ctg ctc aga gcc gtt ctt tgc caa ata atc acc     1071
 Ala Ala Ser Pro Ala Leu Leu Arg Ala Val Leu Cys Gln Ile Ile Thr
             320                 325                 330

 ttg tta tta aag agc tga ttgttctact aaaaaaaaaa aa                    1111
 Leu Leu Leu Lys Ser 
         335





      <210> 385
      <211> 946
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (63)..(752)

      <400> 385
 cgtaatctct cagcctttct gtgtctcctt tcctccgcct cagtttgggg cgggtcgggg     60

 ga   atg gct gag gag atg gag tcg tcg ctc gag gca agc ttt tcg tcc     107
      Met Ala Glu Glu Met Glu Ser Ser Leu Glu Ala Ser Phe Ser Ser
        1               5                  10                  15

 agc ggg gca gtg tca ggg gcc tca ggg ttt ttg cct cct gcc cgc tcc      155
 Ser Gly Ala Val Ser Gly Ala Ser Gly Phe Leu Pro Pro Ala Arg Ser
                  20                  25                  30

 cgc atc ttc aag ata atc gtg atc ggc gac tcc aat gtg ggc aag aca      203
 Arg Ile Phe Lys Ile Ile Val Ile Gly Asp Ser Asn Val Gly Lys Thr
              35                  40                  45

 tgc ctg acc tac cgc ttc tgc gct ggc cgc ttc ccc gac cgc acc gag      251
 Cys Leu Thr Tyr Arg Phe Cys Ala Gly Arg Phe Pro Asp Arg Thr Glu
          50                  55                  60

 gcc acg ata ggg gtg gat ttc cga gaa cga gcg gtg gag att gat ggg      299
 Ala Thr Ile Gly Val Asp Phe Arg Glu Arg Ala Val Glu Ile Asp Gly
      65                  70                  75

 gag cgc atc aag atc cag cta tgg gac aca gca gga caa gaa cga ttc      347
 Glu Arg Ile Lys Ile Gln Leu Trp Asp Thr Ala Gly Gln Glu Arg Phe
  80                  85                  90                  95

 aga aag agc atg gtt cag cac tac tac aga aat gta cat gct gtt gtc      395
 Arg Lys Ser Met Val Gln His Tyr Tyr Arg Asn Val His Ala Val Val
                 100                 105                 110

 ttc gtg tat gat atg acc aac atg gct agt ttt cat agc cta cca tct      443
 Phe Val Tyr Asp Met Thr Asn Met Ala Ser Phe His Ser Leu Pro Ser
             115                 120                 125

 tgg ata gaa gaa tgc aaa caa cat ttg cta gcc aat gat ata cca cgg      491
 Trp Ile Glu Glu Cys Lys Gln His Leu Leu Ala Asn Asp Ile Pro Arg
         130                 135                 140

 att ctt gtt gga aat aaa tgt gac ttg aga agt gcc ata cag gta ccc      539
 Ile Leu Val Gly Asn Lys Cys Asp Leu Arg Ser Ala Ile Gln Val Pro
     145                 150                 155

 aca gac ttg gca caa aaa ttt gct gac aca cac agt atg cct ttg ttt      587
 Thr Asp Leu Ala Gln Lys Phe Ala Asp Thr His Ser Met Pro Leu Phe
 160                 165                 170                 175

 gaa acg tct gct aaa aac ccc aat gat aat gac cat gtg gaa gct ata      635
 Glu Thr Ser Ala Lys Asn Pro Asn Asp Asn Asp His Val Glu Ala Ile
                 180                 185                 190

 ttt atg acc ttg gct cat aag ctt aag agc cac aaa cca tta atg ctt      683
 Phe Met Thr Leu Ala His Lys Leu Lys Ser His Lys Pro Leu Met Leu
             195                 200                 205

 agt cag ccc cct gat aat gga att atc ctg aag cct gaa cca aag cct      731
 Ser Gln Pro Pro Asp Asn Gly Ile Ile Leu Lys Pro Glu Pro Lys Pro
         210                 215                 220

 gca atg acg tgc tgg tgc taa at aacagtcttt attatattat ctaattttga      784
 Ala Met Thr Cys Trp Cys 
     225

 ctaaagaaat acttttgaag tatgacagta ttaagtcata agatttaatc tcaactataa    844

 tgggtcatct tgacactttg ctgtttgtca ttgtcacgct tttgtatttt gtatctactt    904

 aagtttgtca ctggaacagc acaggaaaag ttgcaacaaa tt                       946




      <210> 386
      <211> 2584
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (272)..(2191)

      <400> 386
 tttcgttgga gaagcaagga ggcgattggc gctggtgaat gccaatgccc ccgccgggcg     60

 gctgaggggg cggagcctca gccgctgtgg atggggagtg gaggcggagg ggagcggagc    120

 ccggagcgtc gtggaaagca ttggacacat ttccaccatg ctaatggcat tttaaatata    180

 tttggcaatt ttcccaattt tttactgaag aaaactgtaa gtttatactt gaggactgaa    240

 gtgtgactct gccgattatc aggctttcaa g   atg aat ctg gaa aaa ctc agc     292
                                      Met Asn Leu Glu Lys Leu Ser
                                        1               5

 aag cct gaa ctc ctg aca cta ttt agt att ctt gaa gga gag ctt gaa      340
 Lys Pro Glu Leu Leu Thr Leu Phe Ser Ile Leu Glu Gly Glu Leu Glu
          10                  15                  20

 gca agg gac ctt gtt ata gaa gcc tta aag gcc caa cac aga gat act      388
 Ala Arg Asp Leu Val Ile Glu Ala Leu Lys Ala Gln His Arg Asp Thr
      25                  30                  35

 ttc att gaa gaa cgc tat gga aaa tat aac atc agt gat cct tta atg      436
 Phe Ile Glu Glu Arg Tyr Gly Lys Tyr Asn Ile Ser Asp Pro Leu Met
  40                  45                  50                  55

 gct cta cag aga gat ttt gaa aca ctg aag gag aaa aat gat ggc gaa      484
 Ala Leu Gln Arg Asp Phe Glu Thr Leu Lys Glu Lys Asn Asp Gly Glu
                  60                  65                  70

 aag cag cca gtc tgc aca aat cca ctc tct att ctt aag gtt gtg atg      532
 Lys Gln Pro Val Cys Thr Asn Pro Leu Ser Ile Leu Lys Val Val Met
              75                  80                  85

 aag cag tgc aag aac atg cag gag cgc atg ctg tcc cag ctg gct gct      580
 Lys Gln Cys Lys Asn Met Gln Glu Arg Met Leu Ser Gln Leu Ala Ala
          90                  95                 100

 gct gag agc agg cac cga aag gtg atc cta gac ctt gag gaa gaa agg      628
 Ala Glu Ser Arg His Arg Lys Val Ile Leu Asp Leu Glu Glu Glu Arg
     105                 110                 115

 cag cgg cat gca cag gat acg gct gaa gga gat gat gtc acc tac atg      676
 Gln Arg His Ala Gln Asp Thr Ala Glu Gly Asp Asp Val Thr Tyr Met
 120                 125                 130                 135

 cta gag aag gaa aga gag agg ctg act caa cag ttg gaa ttt gaa aaa      724
 Leu Glu Lys Glu Arg Glu Arg Leu Thr Gln Gln Leu Glu Phe Glu Lys
                 140                 145                 150

 tcc caa gtg aaa aag ttt gaa aaa gaa cag aag aag ctc tct agt cag      772
 Ser Gln Val Lys Lys Phe Glu Lys Glu Gln Lys Lys Leu Ser Ser Gln
             155                 160                 165

 ctg gaa gag gag cgc tcc cgc cac aag cag ctc tca tcc atg cta gtg      820
 Leu Glu Glu Glu Arg Ser Arg His Lys Gln Leu Ser Ser Met Leu Val
         170                 175                 180

 ctt gag tgc aag aaa gcc acc aac aag gca gcc gag gaa gga cag aag      868
 Leu Glu Cys Lys Lys Ala Thr Asn Lys Ala Ala Glu Glu Gly Gln Lys
     185                 190                 195

 gca gga gag ctg agc ctg aaa ttg gag aag gag aag agc cgg gtg agt      916
 Ala Gly Glu Leu Ser Leu Lys Leu Glu Lys Glu Lys Ser Arg Val Ser
 200                 205                 210                 215

 aaa ctg gaa gaa gag ttg gca gct gag aga aag aga ggc ttg cag act      964
 Lys Leu Glu Glu Glu Leu Ala Ala Glu Arg Lys Arg Gly Leu Gln Thr
                 220                 225                 230

 gag gcc cag gta gag aag cag tta tca gag ttt gac atc gaa agg gaa     1012
 Glu Ala Gln Val Glu Lys Gln Leu Ser Glu Phe Asp Ile Glu Arg Glu
             235                 240                 245

 caa ctg aga gca aaa ctg aac cga gaa gag aac cgg acc aaa acc ctg     1060
 Gln Leu Arg Ala Lys Leu Asn Arg Glu Glu Asn Arg Thr Lys Thr Leu
         250                 255                 260

 aaa gaa gaa atg gaa agt tta aag aag ata gtg aag gac cta gag gct     1108
 Lys Glu Glu Met Glu Ser Leu Lys Lys Ile Val Lys Asp Leu Glu Ala
     265                 270                 275

 tcc cac cag cac agt agc cct aat gag caa ttg aag aaa cca gta acc     1156
 Ser His Gln His Ser Ser Pro Asn Glu Gln Leu Lys Lys Pro Val Thr
 280                 285                 290                 295

 gtg tcc aaa ggc aca gca act gag cct ctc atg cta atg tct gtg ttt     1204
 Val Ser Lys Gly Thr Ala Thr Glu Pro Leu Met Leu Met Ser Val Phe
                 300                 305                 310

 tgc caa aca gag agt ttt cca gca gaa aga acc cat ggg agc aac ata     1252
 Cys Gln Thr Glu Ser Phe Pro Ala Glu Arg Thr His Gly Ser Asn Ile
             315                 320                 325

 gcc aag atg aca aac act ggg ctg cct ggt cct gcc act cct gct tac     1300
 Ala Lys Met Thr Asn Thr Gly Leu Pro Gly Pro Ala Thr Pro Ala Tyr
         330                 335                 340

 tca tat gca aaa acc aat ggc cat tgt gac cca gag ata caa act acc     1348
 Ser Tyr Ala Lys Thr Asn Gly His Cys Asp Pro Glu Ile Gln Thr Thr
     345                 350                 355

 agg gag ctg act gca ggc aac aat gta gaa aac caa gtg cct cca cgg     1396
 Arg Glu Leu Thr Ala Gly Asn Asn Val Glu Asn Gln Val Pro Pro Arg
 360                 365                 370                 375

 gaa aaa tct gtg gca ttg gcc caa gag aaa cca gtg gag aat ggt ggg     1444
 Glu Lys Ser Val Ala Leu Ala Gln Glu Lys Pro Val Glu Asn Gly Gly
                 380                 385                 390

 tgt cct gtg ggg att gag act cca gtc cca atg ccc agt ccc ctc tct     1492
 Cys Pro Val Gly Ile Glu Thr Pro Val Pro Met Pro Ser Pro Leu Ser
             395                 400                 405

 tcc agt ggg agc tca ctg tct ccc agc agc act gcc tcc tcc tct cta     1540
 Ser Ser Gly Ser Ser Leu Ser Pro Ser Ser Thr Ala Ser Ser Ser Leu
         410                 415                 420

 aca tcc tct cct tgc tct tcg ccg gta ctc act aag cgt tta ttg ggg     1588
 Thr Ser Ser Pro Cys Ser Ser Pro Val Leu Thr Lys Arg Leu Leu Gly
     425                 430                 435

 tca tca gct agc agc cct ggc tac cag tca tcg tac caa gta ggg atc     1636
 Ser Ser Ala Ser Ser Pro Gly Tyr Gln Ser Ser Tyr Gln Val Gly Ile
 440                 445                 450                 455

 aac caa cgg ttc cat gca gct cgc cac aaa ttt cag tcc caa gca gat     1684
 Asn Gln Arg Phe His Ala Ala Arg His Lys Phe Gln Ser Gln Ala Asp
                 460                 465                 470

 cag gac caa caa gcc agt ggc cta cag agc cct cca tcc agg gat tta     1732
 Gln Asp Gln Gln Ala Ser Gly Leu Gln Ser Pro Pro Ser Arg Asp Leu
             475                 480                 485

 tcc ccc acc ctc ata gac aac tct gcc gcc aag cag ctg gcc cga aac     1780
 Ser Pro Thr Leu Ile Asp Asn Ser Ala Ala Lys Gln Leu Ala Arg Asn
         490                 495                 500

 aca gtc act cag gtg ctc tcc aga ttc act agc caa caa ggg cca atc     1828
 Thr Val Thr Gln Val Leu Ser Arg Phe Thr Ser Gln Gln Gly Pro Ile
     505                 510                 515

 aag cca gtc tct ccc aac agc tct ccc ttt ggc aca gac tat cga aat     1876
 Lys Pro Val Ser Pro Asn Ser Ser Pro Phe Gly Thr Asp Tyr Arg Asn
 520                 525                 530                 535

 cta gcc aac act gcc aat cca aga ggt gac aca agc cat tca cct act     1924
 Leu Ala Asn Thr Ala Asn Pro Arg Gly Asp Thr Ser His Ser Pro Thr
                 540                 545                 550

 cca ggg aaa gtg tcc agt ccc ctg agc ccc ctg tct cca gga atc aag     1972
 Pro Gly Lys Val Ser Ser Pro Leu Ser Pro Leu Ser Pro Gly Ile Lys
             555                 560                 565

 tcc cca acc atc ccc aga gct gag aga gga aac cct cca ccc atc cca     2020
 Ser Pro Thr Ile Pro Arg Ala Glu Arg Gly Asn Pro Pro Pro Ile Pro
         570                 575                 580

 ccc aag aaa cct ggc ctc acc cct tct cca tct gct acc act cca ttg     2068
 Pro Lys Lys Pro Gly Leu Thr Pro Ser Pro Ser Ala Thr Thr Pro Leu
     585                 590                 595

 acc aaa act cat tcc cag gca gcc tct ttg acc act gca gaa gac ctt     2116
 Thr Lys Thr His Ser Gln Ala Ala Ser Leu Thr Thr Ala Glu Asp Leu
 600                 605                 610                 615

 gcc agc agc tgc tct tcc aat act gtt gta gca aat ggt aag gat gtt     2164
 Ala Ser Ser Cys Ser Ser Asn Thr Val Val Ala Asn Gly Lys Asp Val
                 620                 625                 630

 gag tta ctt ttg cct acc agc agc tag tccct aggagggagt ctccacgttt     2216
 Glu Leu Leu Leu Pro Thr Ser Ser 
             635

 gacattccat cagatttcgt ccaaaagctc agtcagactt ctgagtcaga ttatgttatt   2276

 tattttgata gtagctgaaa ccatctgtat aatacattta gtatatttca ccattttgta   2336

 tttttttaag tagaaactga gtagtttgga tttttatggc tcacatcttt ttactgaagc   2396

 cagaaaggca cctcaaagat gtctcaagct cagcagtcac cgtcatgttg tgatgaaaaa   2456

 agcgaatcac caggtggtga tttgctatct atttgagaac tagaatcact caacactcat   2516

 tttgaattat gcaagaaggg ttcatgcaga ttttttttcc agatgaacat gttttaaaaa   2576

 tgcctgaa                                                            2584




      <210> 387
      <211> 733
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(329)

      <400> 387
 gggtctgagt gcattcaata aatcctcctc cttttacccc gtggtctttc tggttctcct     60

 gattctgcaa ccgttgtgtc ttccatgtaa aattctgaga ctccagcagg   atg tct     116
                                                          Met Ser
                                                            1

 tat caa cag cag cag tgc aag cag ccc tgc cag cca cct cct gtg tgc      164
 Tyr Gln Gln Gln Gln Cys Lys Gln Pro Cys Gln Pro Pro Pro Val Cys
           5                  10                  15

 ccc gcg cca aag tgc cca gag cca tgt cca ccc ccg aag tgc cct gag      212
 Pro Ala Pro Lys Cys Pro Glu Pro Cys Pro Pro Pro Lys Cys Pro Glu
      20                  25                  30

 ccc tgc cca cca tca aag tgt cca cag tcc tgc cca cct cag cag tgc      260
 Pro Cys Pro Pro Ser Lys Cys Pro Gln Ser Cys Pro Pro Gln Gln Cys
  35                  40                  45                  50

 cag cag aaa tgt cct cct gtg aca cct tcc cca ccc tgc cag cca aag      308
 Gln Gln Lys Cys Pro Pro Val Thr Pro Ser Pro Pro Cys Gln Pro Lys
                  55                  60                  65

 tgt cca ccc aag agc aag taa ca gcttcaggat tcatcaggag catgaaagga      361
 Cys Pro Pro Lys Ser Lys 
              70

 taaggataat tggctcacct cgttccacag ctccacctgc atcttctcat caaagccatc    421

 cagggataca cagggagctt ctttcctctt agcctgtgat cggcctgtga tgatctctga    481

 tagcaaaagg ttttcttttt gaggctgcca tactgccact gtccaggtgg agactgagca    541

 aaggaagtcc tgggctgtgc cagctcccag agcttcagaa gaaagagcag ctctctccct    601

 gggaaccatt agagaattct gttgatgttt tctgtgtctg tctgtcccct gggcatgagc    661

 ttccaccacc tgtgcagttg tcactttcct ttcactccct gaataaagaa tctatgcata    721

 aaaaaaaaaa aa                                                        733




      <210> 388
      <211> 1392
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (190)..(1020)

      <400> 388
 ccgccggcgc cgcggggagg tggtggaggc ctagccggag ccgagaggtc tcttgttccc     60

 gtcccacggt cccggcgtca cccctccggc gcccagtccc cgtcccggaa ctcccgggcc    120

 tgtcctgggc ccccggtctg tgcactccgc tcgccgcagc gcccggcccg ggccgcaccc    180

 gccggcccc    atg agg agg gac gtg aac gga gtg acc aag agc agg ttt     228
              Met Arg Arg Asp Val Asn Gly Val Thr Lys Ser Arg Phe
                1               5                  10

 gag atg ttc tca aat agt gat gaa gct gta atc aat aaa aaa ctt ccc      276
 Glu Met Phe Ser Asn Ser Asp Glu Ala Val Ile Asn Lys Lys Leu Pro
      15                  20                  25

 aaa gaa ctc ctg tta cgg ata ttt tct ttt cta gat gtt gtt acc ctg      324
 Lys Glu Leu Leu Leu Arg Ile Phe Ser Phe Leu Asp Val Val Thr Leu
  30                  35                  40                  45

 tgc cgc tgt gct cag gtc tcc agg gcc tgg aat gtt ctg gct ctg gat      372
 Cys Arg Cys Ala Gln Val Ser Arg Ala Trp Asn Val Leu Ala Leu Asp
                  50                  55                  60

 ggc agt aac tgg cag cga att gac cta ttt gat ttc cag agg gat att      420
 Gly Ser Asn Trp Gln Arg Ile Asp Leu Phe Asp Phe Gln Arg Asp Ile
              65                  70                  75

 gag ggc cga gta gtg gag aat att tca aaa cga tgt ggg ggc ttt tta      468
 Glu Gly Arg Val Val Glu Asn Ile Ser Lys Arg Cys Gly Gly Phe Leu
          80                  85                  90

 cga aag tta agt ctt cgt gga tgt ctt gga gtg gga gac aat gca tta      516
 Arg Lys Leu Ser Leu Arg Gly Cys Leu Gly Val Gly Asp Asn Ala Leu
      95                 100                 105

 aga acc ttt gca caa aac tgc agg aac att gaa gta ctg aat cta aat      564
 Arg Thr Phe Ala Gln Asn Cys Arg Asn Ile Glu Val Leu Asn Leu Asn
 110                 115                 120                 125

 ggg tgt aca aag aca aca gac gct aca tgt act agc ctt agc aag ttc      612
 Gly Cys Thr Lys Thr Thr Asp Ala Thr Cys Thr Ser Leu Ser Lys Phe
                 130                 135                 140

 tgt tcc aaa ctc agg cac ctt gac ttg gct tcc tgt aca tca ata aca      660
 Cys Ser Lys Leu Arg His Leu Asp Leu Ala Ser Cys Thr Ser Ile Thr
             145                 150                 155

 aac atg tct cta aaa gct ctg agt gag gga tgt cca ctg ttg gag cag      708
 Asn Met Ser Leu Lys Ala Leu Ser Glu Gly Cys Pro Leu Leu Glu Gln
         160                 165                 170

 ttg aac att tcc tgg tgt gac caa gta acc aag gat ggc att caa gca      756
 Leu Asn Ile Ser Trp Cys Asp Gln Val Thr Lys Asp Gly Ile Gln Ala
     175                 180                 185

 cta gtg agg ggc tgt ggg ggt ctc aag gcc tta ttc tta aaa ggc tgc      804
 Leu Val Arg Gly Cys Gly Gly Leu Lys Ala Leu Phe Leu Lys Gly Cys
 190                 195                 200                 205

 acg cag cta gaa gat gaa gct ctc aag tac ata ggt gca cac tgc cct      852
 Thr Gln Leu Glu Asp Glu Ala Leu Lys Tyr Ile Gly Ala His Cys Pro
                 210                 215                 220

 gaa ctg gtg act ttg aac ttg cag act tgc ttg caa atc aca gat gaa      900
 Glu Leu Val Thr Leu Asn Leu Gln Thr Cys Leu Gln Ile Thr Asp Glu
             225                 230                 235

 ggt ctc att act ata tgc aga ggg tgc cat aag tta caa tcc ctt tgt      948
 Gly Leu Ile Thr Ile Cys Arg Gly Cys His Lys Leu Gln Ser Leu Cys
         240                 245                 250

 gcc tct ggc tgc tcc aac atc aca gat gcc atc ctg aat gct cta ggt      996
 Ala Ser Gly Cys Ser Asn Ile Thr Asp Ala Ile Leu Asn Ala Leu Gly
     255                 260                 265

 cag aac tgc cca cgg ctt agg taa acatttcttg tttagctcaa aaaaatcata    1050
 Gln Asn Cys Pro Arg Leu Arg 
 270                 275

 gaacaaaagt ttccttcacc catatttctt ccttggaact ttggaatttt aaggtaggca   1110

 ctgcagacgc tttgaaattt taaggtagtc ccttttagat gcccacctac ttcctttttg   1170

 tacctcattt gatttcatgt aattggtgtg aaccaagggg taacaatccc caaattccac   1230

 tacttgctat ccatactaga aaaaagaatc aacattttat tacttgagat agaaagaaag   1290

 gtattttctc ttattaatgc ttttgtataa ttcttttctc aaagtagttt ttaaaggtcc   1350

 accctaaggt catttgtcat agtaatgata ccaggtacat ag                      1392




      <210> 389
      <211> 4162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (386)..(877)

      <400> 389
 ggatggagag gctggtggaa ggagaaatca gccgaccccc ttgggtcatc tccagttgca     60

 agatggcgtg gcccttgccc agggtgctgc cctccctgtt ggaatccagg gcatggggct    120

 atggcccgac caccaaatct ggctgcagct tggatggata gcttatcttc ctttgcaggt    180

 ttctagggga gagtttaacc aggtatcagg aaggacttta cggcaggaag agcagctggg    240

 tgggaaaggg attcagggga acattggtga aagaagccac agtcctggca agacgaggga    300

 cttgagccct cctggagccc ccaacctggc tgactgtcct gctcttttcc tgcccactcc    360

 aggctggcct gccactcctc ctgct  atg atg cct ggg cag atc ccg gac cct     412
                              Met Met Pro Gly Gln Ile Pro Asp Pro
                                1               5

 tcg gtg acc aca ggc tcc ctg cca ggg ctt ggc ccc ctg acc ggg ctc      460
 Ser Val Thr Thr Gly Ser Leu Pro Gly Leu Gly Pro Leu Thr Gly Leu
  10                  15                  20                  25

 ccc agc tcg gcc ctg act gtg gag gag ctg aaa tac gct gac atc cgc      508
 Pro Ser Ser Ala Leu Thr Val Glu Glu Leu Lys Tyr Ala Asp Ile Arg
                  30                  35                  40

 aac ctc ggg gcc atg att gca ccc ttg cac ttc ctg gag gtg aaa ctg      556
 Asn Leu Gly Ala Met Ile Ala Pro Leu His Phe Leu Glu Val Lys Leu
              45                  50                  55

 ggc aag agg ccc cag ccc gtg aaa agt gag cta gat gag gaa gag gag      604
 Gly Lys Arg Pro Gln Pro Val Lys Ser Glu Leu Asp Glu Glu Glu Glu
          60                  65                  70

 cga agg aaa agg cgc cgg gag aag aac aaa gtc gca gca gcc cga tgc      652
 Arg Arg Lys Arg Arg Arg Glu Lys Asn Lys Val Ala Ala Ala Arg Cys
      75                  80                  85

 cgg aac aag aag aag gag cgc acg gag ttt ctg cag cgg gaa tcc gag      700
 Arg Asn Lys Lys Lys Glu Arg Thr Glu Phe Leu Gln Arg Glu Ser Glu
  90                  95                 100                 105

 cgg ctg gaa ctc atg aac gca gag ctg aag acc cag att gag gag ctg      748
 Arg Leu Glu Leu Met Asn Ala Glu Leu Lys Thr Gln Ile Glu Glu Leu
                 110                 115                 120

 aag cag gag cgg cag cag ctc atc ctg atg ctg aac cga cac cgc ccc      796
 Lys Gln Glu Arg Gln Gln Leu Ile Leu Met Leu Asn Arg His Arg Pro
             125                 130                 135

 acc tgc atc gtc cgg acc gac agt gtc aag acc ccc gag tca gaa ggc      844
 Thr Cys Ile Val Arg Thr Asp Ser Val Lys Thr Pro Glu Ser Glu Gly
         140                 145                 150

 aac cca ctg ctc gag cag ctc gag aag aag tga ccatgggc tgggaggagg      895
 Asn Pro Leu Leu Glu Gln Leu Glu Lys Lys 
     155                 160

 tggaggagga ggaagaggag aaggaaaagt gacgaagaga gaggaggagg ggggccccag    955

 atggcccttc ctttggtgca tgaaaaactg tacaatgagg ttcagcacag ccagcatcag   1015

 ccgagctttt ttgtgaaact cagatcagcc acccaggagg aagagcgggc tgaggaaacc   1075

 cagagggacc aagcgctgag accaaagttg accctcgggt agggttgtcc tgcctggggc   1135

 cccacttgaa ggaggcagga cagaggcacc gaggccaggg agacgcccaa cgaggcagcc   1195

 ctgggctctt ctctggcctc ttcaccaggg cacccatcca aggaacctcc gaacagccag   1255

 gaaaagccat gagttgcaac caaaacgcgg ctgaggatgg aactcagaat gaaactgcaa   1315

 cccacctgcc cccagccctg cccctcgccc tgatgcgaag ctggagaggg gcgtgctgcg   1375

 gggccctgat gcccccaccc acctcggtcc agcgcggccc tgcccaggag gcggcagccg   1435

 ggcgcaccct cgccagccct gctggagttt gctgtgggca ctgaggcgcg ggcgcccttc   1495

 caaagcacat actcaccgaa tgtttacaga ctggctgtcc tggcagggct ttcaactgca   1555

 catgtttttt atactttcct tttttttttt ttttttaata ttttttacaa aaaaaaagat   1615

 tttatacaag caatatatat atggatttct ataatcactc gatgtgatac agtataaata   1675

 tgctatggtt tgtttgttat gaacagatag ccaccagtta cggccgttgt gtgtaactcc   1735

 taagtactgt agtctctggg tgtcgggggt ggccagggcg ggggcggggt gcatttccat   1795

 ccttgtaaac ccttcatagt actcagtcct gtatcgctca gtaaacattg ctcttactta   1855

 aaaaattttt tttttttttt ttattttaga tacagccttt attttttttt ccacgggaag   1915

 ttaaaaatcc atcataagac tccataagac tttactagtc ttgcatgtag actctaggag   1975

 tttgtgatct gataaaagag taacatgaaa atttactgta ttgccctaat ttcatacttc   2035

 cttgtacaca atgaatcact ctgagaatct attccaaggg ttatatacac aaaagtgtca   2095

 agaataaaat gttctccact ctcgcataaa aatgtgtaca gtgtatcagg aatggaaaac   2155

 ttctaatttt cctgggcccg ggcttcatgg atttctgctg ccagaagatg aaagactcct   2215

 tctgctttat tgctccattg ttctgaggat taatcatcca accctggcgt ttctccttgt   2275

 tggattctag acgctattct gatggcttct tccagagatg gctgttctcc aagctgaact   2335

 gcaatctggg tgccattgga tgttgctact aaggtcagag gtctggtttc tgtggttact   2395

 aagtgatggc tatgctgctg gtgccccatt tctgatgagg cagtatggaa tgctgccaag   2455

 tcttgagcta caattgcaac ctgttcccct tctgtaccct cagcagtaac catagcaaca   2515

 gagtgcgttc ctgctgagga gatgactgca tcatgggcgg ggactgtgat gggcgtgcca   2575

 tcctgcgtta ccattgtgat ggtgttgcca atggcctgca tgtcagcttg agatatgttg   2635

 acatgctgag tcccatcctg ggatatgagt gtaacttgtt gactcagtcc agattgggtt   2695

 actgtggcta cttgtgtaga aacaacgtcg tccccttcta cacctgtaac atacgtaatc   2755

 tgggaccctt taagaacatc ttcaccttga cctgggggcg gctcaaagaa ggcttcctgc   2815

 tcctcctcga tgggctcagt gtcgttgtgg gctgtccgtt tgtgcatggc cagcgtggag   2875

 atctgcttgt atgtcttccc acagtggtta cagttgtaag gtttggaatg agtgtggaca   2935

 acatgatgtt tgtacaaact ggaatattct gtaaaccttt tgtcacaccc aggaactgta   2995

 caaacatatg gcttttctcc tgtgtgtatc ctcacatggt ttttataatt tgttgcactg   3055

 gcaaatgccc tcccacatcc tggctctgtg cagtaataag gtctttctcc tgtgtgtgtc   3115

 ctaacgtgca cttttctgat atttgatgtt gtaaaggacc gaccgcagcc ttcgaaggga   3175

 cacttaaagg gcctttctcc tgtatgagtt ctgatgtgtt tctgtagatc tcctgaagtt   3235

 ttgaaagatt tagtacaatt atcttccgaa caccgatatg gcttttctcc tgtatgagtt   3295

 ctgacgtgac tttttaatcc ataacctgtt gcaaatgcct tcccacagcc tgcatgctca   3355

 cactgataag gccgatctcc tgtgtgtgac ctctcatgga ccttgagatg atgagctgtt   3415

 gtatataatt ttccacatcc atcatattca catcgaaatg ccttctctcc actctgttga   3475

 gatttagcag ttactcttgt agcatgtcct tgtaaaacaa tctgcatttt tttctcttgc   3535

 tcattttctc caatcattcc agtacctgct acactttcac ttccatcaat ggacaccttt   3595

 gctgcatact gttccaaagc actgatggtg tcagggtcaa ttgtagcatc cccagtgtgc   3655

 agacctgcca ctgtcccatc agcctgaatt gccaagatgg tgtcagactg cgggacttgc   3715

 actgcatggt ggatataagc tgtggtacca tcttccagct gaaccgcctg taatgcactc   3775

 tggtcataac tatctttgga ggtgtggtga ataaatgctg tggtaccatc ttctaactgt   3835

 actgcttgac catcctctag acgcaaactg tcccctgtac ttttaggtat gggtacatgt   3895

 tgaacatagg ccgcagaacc atcttccaac tgaatgacct ggccatctat gagttttgca   3955

 tctttagaat tgtgttgtat gtaagcagta gaaccatctg caagtgttac tgcttgcaag   4015

 cttacgcctt ccatattttc taagttgtca ccatctgcca cggtgactgc ctctgtcaag   4075

 cacagcgtaa catgttgcgc ctccatccct cctccaggaa actctgtcat tccctgagaa   4135

 tctcgattta tttgggctaa cctttag                                       4162




      <210> 390
      <211> 1006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (111)..(833)

      <400> 390
 aggtctaatg tgcggctggc ggtggaggtg cgaatcagcc gcgagctgcg agagaagctg     60

 gctgagctgg ggcccgtgcg gggagacgcc gaggggggcg catccccacc   atg ggc     116
                                                          Met Gly
                                                            1

 tgc ctg gac ctg ccc gga gag gat atg agg aag aca tgg aga cga ttt      164
 Cys Leu Asp Leu Pro Gly Glu Asp Met Arg Lys Thr Trp Arg Arg Phe
           5                  10                  15

 gaa gtc cca aca tcc aag tca tct aat tca gag gat gat ctc cct gaa      212
 Glu Val Pro Thr Ser Lys Ser Ser Asn Ser Glu Asp Asp Leu Pro Glu
      20                  25                  30

 gat tat cca gtg gtc aaa aaa atg ctt cat aga ctg aca gcc gac ctg      260
 Asp Tyr Pro Val Val Lys Lys Met Leu His Arg Leu Thr Ala Asp Leu
  35                  40                  45                  50

 acc ctg gac cct ggg acc gca cac cgc cgc ctg ctc atc tcc gcc gac      308
 Thr Leu Asp Pro Gly Thr Ala His Arg Arg Leu Leu Ile Ser Ala Asp
                  55                  60                  65

 cgc cgc agc gta caa ctg gcc cca cca ggg acg ccc gcg ccc cct gac      356
 Arg Arg Ser Val Gln Leu Ala Pro Pro Gly Thr Pro Ala Pro Pro Asp
              70                  75                  80

 ggc ccc aag cgc ttc gat cag ctc cca gct gtg ctg ggt gcg cag ggc      404
 Gly Pro Lys Arg Phe Asp Gln Leu Pro Ala Val Leu Gly Ala Gln Gly
          85                  90                  95

 ttc ggg gcc ggc cgc cac tgc tgg gag gtg gag act gcg gac gcc gcc      452
 Phe Gly Ala Gly Arg His Cys Trp Glu Val Glu Thr Ala Asp Ala Ala
     100                 105                 110

 tcc tgc aga gac tct tct ggg gag gat gcg gac gac gag gag agc cac      500
 Ser Cys Arg Asp Ser Ser Gly Glu Asp Ala Asp Asp Glu Glu Ser His
 115                 120                 125                 130

 tat gca gtg ggc gcg gcc ggg gaa tca gtg caa cgc aag ggc tgc gta      548
 Tyr Ala Val Gly Ala Ala Gly Glu Ser Val Gln Arg Lys Gly Cys Val
                 135                 140                 145

 agg ctg tgc cct gcg ggg gcc gtg tgg gcc gtg gag ggc cgc ggc ggc      596
 Arg Leu Cys Pro Ala Gly Ala Val Trp Ala Val Glu Gly Arg Gly Gly
             150                 155                 160

 cgc ctg tgg gcc ctc acg gca ccc gaa ccc acc ctg ctg ggc ggt gtt      644
 Arg Leu Trp Ala Leu Thr Ala Pro Glu Pro Thr Leu Leu Gly Gly Val
         165                 170                 175

 gag ccc ccg ccg cgg cgc att cgc gtg gac ctg gac tgg gag cgg ggc      692
 Glu Pro Pro Pro Arg Arg Ile Arg Val Asp Leu Asp Trp Glu Arg Gly
     180                 185                 190

 cgc gtg gcc ttc tac gac ggc cgc tca ctc gac ctg ctt tac gcc ttc      740
 Arg Val Ala Phe Tyr Asp Gly Arg Ser Leu Asp Leu Leu Tyr Ala Phe
 195                 200                 205                 210

 cag gcg cct ggc ccc ctg ggg gag cgc atc ttc ccg ctg ttc tgc acc      788
 Gln Ala Pro Gly Pro Leu Gly Glu Arg Ile Phe Pro Leu Phe Cys Thr
                 215                 220                 225

 tgc gac cct cgt gct ccg ctc cgc att gta cca gcg gaa agc tga gtc      836
 Cys Asp Pro Arg Ala Pro Leu Arg Ile Val Pro Ala Glu Ser 
             230                 235                 240

 tcgtctccaa ctagaagttt ggcccggcca ctggccctgc agctgctttt tgggggtgga    896

 attccccact catttctggg aacacattca cacgcccatt gcaggagtat taatagcaac    956

 ccacattttc gccccaaaat aatgagacct cacctggtct ccacgtttcc              1006




      <210> 391
      <211> 1889
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (340)..(897)

      <400> 391
 gctggggggc ttagaatttt atttttggtt tacagcgcag aagaagagca gtgaggccgg     60

 ggcgcgggtg gggagggcaa ggcggcggct caaaaaaaaa gccagcccct cgcggcccga    120

 cagagtctcg gcgccccgcg ggtcggtgga gcctcatggg tgagcgcagg ccggagacag    180

 gggaacccgc cgcgggacag gggaaggccg gacggaacgc gggtaagctg ccgcagcttc    240

 cggccgggcc actagcgcgg accctacggc cggggcggga cttccggcaa ggcgcggaag    300

 cggcggtagc tgcagctggc gaagttgggc gactggcgg   atg cag gcc ttg cgg     354
                                              Met Gln Ala Leu Arg
                                                1               5

 cac gtc gtg tgc gcc ctg tcc ggc ggc gtg gac agc gcc gtg gcc gcg      402
 His Val Val Cys Ala Leu Ser Gly Gly Val Asp Ser Ala Val Ala Ala
                  10                  15                  20

 ctg ctg ctg agg cgg aga ggt tac cag gtg aca ggg gtg ttt atg aag      450
 Leu Leu Leu Arg Arg Arg Gly Tyr Gln Val Thr Gly Val Phe Met Lys
              25                  30                  35

 aac tgg gac tca ctg gat gaa cat ggg gtc tgt act gcc gac aaa gac      498
 Asn Trp Asp Ser Leu Asp Glu His Gly Val Cys Thr Ala Asp Lys Asp
          40                  45                  50

 tgt gaa gat gct tac aga gtt tgc cag atc tta gac atc cct ttc cat      546
 Cys Glu Asp Ala Tyr Arg Val Cys Gln Ile Leu Asp Ile Pro Phe His
      55                  60                  65

 caa gtg tcc tac gta aag gag tat tgg aat gat gtg ttc agt gac ttt      594
 Gln Val Ser Tyr Val Lys Glu Tyr Trp Asn Asp Val Phe Ser Asp Phe
  70                  75                  80                  85

 ttg aat gag tat gaa aaa gga agg act ccc aat cct gac ata gtt tgc      642
 Leu Asn Glu Tyr Glu Lys Gly Arg Thr Pro Asn Pro Asp Ile Val Cys
                  90                  95                 100

 aac aag cac atc aaa ttt agt tgc ttt ttt cat tat gct gtg gat aat      690
 Asn Lys His Ile Lys Phe Ser Cys Phe Phe His Tyr Ala Val Asp Asn
             105                 110                 115

 ctt ggg gca gat gcc att gcc aca ggt cac tat gca aga act tcc ctg      738
 Leu Gly Ala Asp Ala Ile Ala Thr Gly His Tyr Ala Arg Thr Ser Leu
         120                 125                 130

 gaa gat gaa gaa gtc ttt gag cag aag cac gtt aag aag ccc gaa ggg      786
 Glu Asp Glu Glu Val Phe Glu Gln Lys His Val Lys Lys Pro Glu Gly
     135                 140                 145

 ctt ttc aga aat cgg ttt gaa gtt aga aat ggt ttc cca gga tgc cct      834
 Leu Phe Arg Asn Arg Phe Glu Val Arg Asn Gly Phe Pro Gly Cys Pro
 150                 155                 160                 165

 gag gag aac cat ctt ccc tct ggg ggg att aac gaa aga gtt tgt aaa      882
 Glu Glu Asn His Leu Pro Ser Gly Gly Ile Asn Glu Arg Val Cys Lys
                 170                 175                 180

 gaa aat cgc tgc tga gaatagactt catcatgtgc ttcagaagaa agagagcatg      937
 Glu Asn Arg Cys 
             185

 ggcatgtgtt tcatcgggaa gaggaatttt gaacatttcc ttcttcagta tctgcagcct    997

 cgacctggtc actttatttc catagaagac aataaggttc tgggaacaca taaaggttgg   1057

 ttcctgtata ccttgggcca gagagcaaac ataggtggcc tgagagagcc ctggtacgtg   1117

 gtggagaagg acagcgtcaa gggtgacgtg tttgtggccc cccggacaga ccacccagcc   1177

 ctgtacaggg acctgctgag gaccagccgc gtgcactgga ttgcggagga gcctcccgca   1237

 gcactggtcc gggacaagat gatggagtgc cacttccgat tccgccacca gatggcacta   1297

 gtgccctgtg tgctgaccct caatcaagat ggcaccgtgt gggtgacagc tgtgcaggct   1357

 gtgcgtgccc ttgccacagg acagtttgct gtgttctaca agggggacga gtgcctgggc   1417

 agcgggaaga tcctgcggct ggggccgtct gcctacacgc tccagaaggg ccagcgcaga   1477

 gctgggatgg ccactgagag ccccagtgac agcccagaag atggtccagg cctgagtccc   1537

 ttgctctgac agagatggat ctgctagaag gaacctggag agcaggaccc atggctgggc   1597

 ggctggtgag cagtccaggt gcccaagggc cagcttgctg ctgcccaaag cagaggaagc   1657

 cgggctggct gagggtccga aaagcctgca ggggcccggc gagccccagg aagagcctca   1717

 gctccaggct ggggctctgg ctgctggagc atctgctggc tggtggggtg gcccgagttc   1777

 cccttcaccg cccccaggga gggtttccca cctcagagta caccgagggg acctgcagag   1837

 ggggctgtcg ggacagcgtg gaataaacat tatttcaagg acaaaaaaaa aa           1889




      <210> 392
      <211> 2612
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1067)..(1867)

      <400> 392
 atggtttcag agaaaggatt cagtgctcct gtaggacctt ggggcttgct gccccaagtt     60

 tctgctccct gcattccagc acagtgctcc ttgaccatgc cagctgtggc tcaaataagc    120

 ccaggtacag cttcgtctgc tgctctagaa ggcacaagtg gtaatccttg gcagtgtcca    180

 cctgacgcta actctgcagg catgcagaat acacaagcta aggaggcatg gctgcctcta    240

 cctaaattgc aaaagatgcc tcagagagcc ttgggaccca ggcatagaac taccacagag    300

 tcagggccac cacagagaat gatcactagg gtaatgccta gcagagtcat ggggctgggg    360

 ccaccacaga aagtctccac taagtcaatg cttagtgaag ccatgggagc agggccattt    420

 ccatggcccc agaactatag agccaccaac aattccatga agcattacag tggaagccgt    480

 tcatcttcag agcttcaaga aagggtccta aaagccagag tggttgaatg gttgatgaag    540

 gtttttagag gaggacccca gctcatcact gaggaagagg gaaatgcagc cagcggtttg    600

 gcaaactgcc ctccccaaat acccctgttc cagccttcac agtggtttcc tgagcagctc    660

 gaggcgggcc agaaagccag gatttgggat ccgaagcagg acgtgcagac ctacgagggg    720

 ctgcggacgg aggcaccgga gggcacttct cacctccggg tgtgccggga ggggcacgcg    780

 gaccgagctt gcaaatgcag gatgggaccc agcgagggag ccgcgagcga ggctcaccgt    840

 ccccggcgtg caggatccgg ggctgctgag cgctcgctcc cgcgtgtccg gcgcttggag    900

 tccccgcggc aggagaggag tcgggacact agagctccag gggcgcctgt gggctccagg    960

 gcctccggct tccccagtcc ccttcagcta aagccccaga gacgtgctca gccccaggac   1020

 ctctgcggaa caagatccgg attgagaagc cactgcaact accgaa   atg ggc agc    1075
                                                      Met Gly Ser
                                                        1

 aaa acc ttg ccg gcg ccg gtg cct atc cac cct tcc ctg cag ctc acc     1123
 Lys Thr Leu Pro Ala Pro Val Pro Ile His Pro Ser Leu Gln Leu Thr
       5                  10                  15

 aac tac tcc ttc ctt cag gca gtg aac ggc ctg ccc aca gtg cct tcg     1171
 Asn Tyr Ser Phe Leu Gln Ala Val Asn Gly Leu Pro Thr Val Pro Ser
  20                  25                  30                  35

 gac cat ctg ccc aac ctg tat ggt ttc agc gcg ttg cac gct gtg cac     1219
 Asp His Leu Pro Asn Leu Tyr Gly Phe Ser Ala Leu His Ala Val His
                  40                  45                  50

 ctg cat cag tgg acg ctg ggc tac ccg gcc atg cac ttg ccg cgc tct     1267
 Leu His Gln Trp Thr Leu Gly Tyr Pro Ala Met His Leu Pro Arg Ser
              55                  60                  65

 tct ttc tcc aaa gtg ccg ggc acg gtg tcc agc ttg gtg gat gcg cgc     1315
 Ser Phe Ser Lys Val Pro Gly Thr Val Ser Ser Leu Val Asp Ala Arg
          70                  75                  80

 ttc cag ctg ccc gcc ttt ccc tgg ttc cct cat gtc att caa ccc aag     1363
 Phe Gln Leu Pro Ala Phe Pro Trp Phe Pro His Val Ile Gln Pro Lys
      85                  90                  95

 ccc gag atc acc gct gga ggc agc gtt cca gcg ctc aag acc aag ccg     1411
 Pro Glu Ile Thr Ala Gly Gly Ser Val Pro Ala Leu Lys Thr Lys Pro
 100                 105                 110                 115

 cgc ttt gat ttt gcc aac ctg gcc ttg gca gca acg caa gaa gat ccg     1459
 Arg Phe Asp Phe Ala Asn Leu Ala Leu Ala Ala Thr Gln Glu Asp Pro
                 120                 125                 130

 gcc aag ctc ggt cgc ggg gag ggc cca ggc tcc cct gca ggt ggg ctg     1507
 Ala Lys Leu Gly Arg Gly Glu Gly Pro Gly Ser Pro Ala Gly Gly Leu
             135                 140                 145

 ggt gcc ctc ctc gac gtg acc aag ctg tct cca gaa aag aag ccc aca     1555
 Gly Ala Leu Leu Asp Val Thr Lys Leu Ser Pro Glu Lys Lys Pro Thr
         150                 155                 160

 agg gga cgt ctg cct tcc aag acc aag aag gaa ttc gtc tgc aag ttc     1603
 Arg Gly Arg Leu Pro Ser Lys Thr Lys Lys Glu Phe Val Cys Lys Phe
     165                 170                 175

 tgt ggc cgc cac ttc acc aag tcc tac aac cta ctt atc cat gag cgg     1651
 Cys Gly Arg His Phe Thr Lys Ser Tyr Asn Leu Leu Ile His Glu Arg
 180                 185                 190                 195

 acg cac acc gac gag cgg ccc tac acc tgt gac atc tgc cac aaa gcc     1699
 Thr His Thr Asp Glu Arg Pro Tyr Thr Cys Asp Ile Cys His Lys Ala
                 200                 205                 210

 ttc cgg agg caa gac cac ctg cga gac cac aga tat att cac tcc aaa     1747
 Phe Arg Arg Gln Asp His Leu Arg Asp His Arg Tyr Ile His Ser Lys
             215                 220                 225

 gag aag ccc ttc aag tgt caa gag tgt ggg aaa gga ttc tgc cag tcc     1795
 Glu Lys Pro Phe Lys Cys Gln Glu Cys Gly Lys Gly Phe Cys Gln Ser
         230                 235                 240

 agg act ctc gct gtc cac aag acg cta cac tca cag gtg aag gag ctc     1843
 Arg Thr Leu Ala Val His Lys Thr Leu His Ser Gln Val Lys Glu Leu
     245                 250                 255

 aaa acc tcc aag atc aaa tgc taa atagaacctg tgggtcacaa ggaccctagg    1897
 Lys Thr Ser Lys Ile Lys Cys 
 260                 265

 cccagcggcc ctctcctcca tagggaccag aagcctgact ctggcgggca gcgggagagg   1957

 cgctcgctcg ggaccttcca cctctccaac attgtcccct gggtccctgg cgcacgcggc   2017

 acttcagagc cccgcccggg gccgcgaccc cgaccgtccc tgctgctccc ctaggacgcg   2077

 gctaaactct tggccaaaag gcggtactca cgtggcggaa gggaaactgc attaaaaaaa   2137

 gaacgaaagc tccgcggagc cgcagcggcg cctctcccag aagtattact ttttctattg   2197

 ttattttata cgttttcttt tttatttttg tctttgacca tataagcttg taactctgac   2257

 tgcggagagt gagtggagag aggagaggca acgaagtcct tagcactggc agctcccacc   2317

 tcctcctccc gcccctgccc ccacccccgg agcctgcaaa agtgtaatcc ctgtatctgc   2377

 ttcagcctcc tgccctaggg accgcggggc agccccctcc cagctcttgc agctcagctg   2437

 gcggccgtgg gctccgggac taggagagcg ggacggggac ctcgggcctg gggtctgcag   2497

 ggggcccggc ctccgctgcc gcgacactgc gagggagcag ccagccaaga gccgggcgtt   2557

 atattgcgat tggcacttta tgctgaccat cggtaacgga catttatcac tggag        2612




      <210> 393
      <211> 2889
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (319)..(2889)

      <400> 393
 ggtggaattc gccatttgtc actggtggct accatatgaa acagttcagg tgtagactcc     60

 tttactattt caactcaaag tctttcggtg aatcatgccc tttattccaa tgagtattac    120

 agatattaga agttcagggc ctcgagtcat tgacatttgt attcatgttg tgtcttcgtc    180

 actagcagta gtgattttaa gtgtcgtgct atgatagctc catgcatgta aagataaaag    240

 ccccaaacac tatcagctgt tcattcagct cgtggaaatt ctaattccgt gttcattttt    300

 tttctataga catttgcc  atg gct gag cac ttc aaa cag atc att aga tgt     351
                      Met Ala Glu His Phe Lys Gln Ile Ile Arg Cys
                        1               5                  10

 cct gtc tgt cta aaa gat ctt gaa gaa gcc gtg caa ctg aaa tgt gga      399
 Pro Val Cys Leu Lys Asp Leu Glu Glu Ala Val Gln Leu Lys Cys Gly
              15                  20                  25

 tat gcc tgc tgc ctc cag tgc ctc aat tca ctc cag aag gag ccc gat      447
 Tyr Ala Cys Cys Leu Gln Cys Leu Asn Ser Leu Gln Lys Glu Pro Asp
          30                  35                  40

 ggg gaa ggt tta ctg tgc cgt ttc tgc tct gtg gtc tct cag aag gat      495
 Gly Glu Gly Leu Leu Cys Arg Phe Cys Ser Val Val Ser Gln Lys Asp
      45                  50                  55

 gac atc aag ccc aag tac aag ctg agg gcg ctg gtt tcc atc atc aag      543
 Asp Ile Lys Pro Lys Tyr Lys Leu Arg Ala Leu Val Ser Ile Ile Lys
  60                  65                  70                  75

 gaa cta gag ccc aag ctg aaa tct gtt cta aca atg aac cca agg atg      591
 Glu Leu Glu Pro Lys Leu Lys Ser Val Leu Thr Met Asn Pro Arg Met
                  80                  85                  90

 agg aag ttt caa gtg gat atg acg ttc gat gtg gac aca gcc aac aac      639
 Arg Lys Phe Gln Val Asp Met Thr Phe Asp Val Asp Thr Ala Asn Asn
              95                 100                 105

 tat ctc atc att tct gaa gac ctg agg agt ttc cga agt ggg gat ttg      687
 Tyr Leu Ile Ile Ser Glu Asp Leu Arg Ser Phe Arg Ser Gly Asp Leu
         110                 115                 120

 agc cag aat agg aag gag caa gct gag agg ttc gac act gcc ctg tgc      735
 Ser Gln Asn Arg Lys Glu Gln Ala Glu Arg Phe Asp Thr Ala Leu Cys
     125                 130                 135

 gtc ctg ggc acc cct cgc ttc act tcc ggc cgc cat tac tgg gag gtg      783
 Val Leu Gly Thr Pro Arg Phe Thr Ser Gly Arg His Tyr Trp Glu Val
 140                 145                 150                 155

 gac gtg ggc acc agc caa gtg tgg gat gtg ggc gtg tgc aag gaa tct      831
 Asp Val Gly Thr Ser Gln Val Trp Asp Val Gly Val Cys Lys Glu Ser
                 160                 165                 170

 gtg aac cga cag ggg aag att gtg ctt tct tca gaa cac ggc ttc ttg      879
 Val Asn Arg Gln Gly Lys Ile Val Leu Ser Ser Glu His Gly Phe Leu
             175                 180                 185

 act gtg ggt tgc aga gaa gga aag gtc ttt gct gcc agc act gtg cct      927
 Thr Val Gly Cys Arg Glu Gly Lys Val Phe Ala Ala Ser Thr Val Pro
         190                 195                 200

 atg act cct ctc tgg gtg agt ccc cag ttg cac aga gtg ggg att ttc      975
 Met Thr Pro Leu Trp Val Ser Pro Gln Leu His Arg Val Gly Ile Phe
     205                 210                 215

 ctg gat gta ggt atg agg tcc att gcc ttt tac aat gtt agt gat ggg     1023
 Leu Asp Val Gly Met Arg Ser Ile Ala Phe Tyr Asn Val Ser Asp Gly
 220                 225                 230                 235

 tgc cat atc tac aca ttc atc gag att cct gtt tgc gag ccc tgg cgt     1071
 Cys His Ile Tyr Thr Phe Ile Glu Ile Pro Val Cys Glu Pro Trp Arg
                 240                 245                 250

 cca ttt ttt gct cat aaa cgt gga agt caa gat gat cag agc atc ctg     1119
 Pro Phe Phe Ala His Lys Arg Gly Ser Gln Asp Asp Gln Ser Ile Leu
             255                 260                 265

 agt atc tgt tct gtg atc aat cca tcc act gcc agt gcc cca gtt tct     1167
 Ser Ile Cys Ser Val Ile Asn Pro Ser Thr Ala Ser Ala Pro Val Ser
         270                 275                 280

 tct gag gga aac tgg ggt ggc tgc gcc ctg gcc tta tgc aag gcc att     1215
 Ser Glu Gly Asn Trp Gly Gly Cys Ala Leu Ala Leu Cys Lys Ala Ile
     285                 290                 295

 gcc ttg tcc gtg tcc tct gca ggt ctg tgg gtt ctg gca cca cct gag     1263
 Ala Leu Ser Val Ser Ser Ala Gly Leu Trp Val Leu Ala Pro Pro Glu
 300                 305                 310                 315

 ccc act ggg cat ctg gtc atc cct ggc acc tct cct ttg gag cca cct     1311
 Pro Thr Gly His Leu Val Ile Pro Gly Thr Ser Pro Leu Glu Pro Pro
                 320                 325                 330

 tgt ccc tgg cta gac agt cac att ttc cag tgc cgt ttt gga aag atg     1359
 Cys Pro Trp Leu Asp Ser His Ile Phe Gln Cys Arg Phe Gly Lys Met
             335                 340                 345

 ttg cct ttg gag aag gcg ttt gcc tcc ccc agg agc tcc cca gcc ccg     1407
 Leu Pro Leu Glu Lys Ala Phe Ala Ser Pro Arg Ser Ser Pro Ala Pro
         350                 355                 360

 ccg gat ctg ccc acg ccg ggg tca gca gcc gga gtc cag cag gaa gaa     1455
 Pro Asp Leu Pro Thr Pro Gly Ser Ala Ala Gly Val Gln Gln Glu Glu
     365                 370                 375

 ccc gag acc atc cct gag agg acc cct gct gac ctg gag ttc tcc cgc     1503
 Pro Glu Thr Ile Pro Glu Arg Thr Pro Ala Asp Leu Glu Phe Ser Arg
 380                 385                 390                 395

 ctg cgt ttc cgg gaa ttt gtc tac cag gag gct gcc ggg ccc cac cag     1551
 Leu Arg Phe Arg Glu Phe Val Tyr Gln Glu Ala Ala Gly Pro His Gln
                 400                 405                 410

 acc ctg gcc cgg ctg cat gag ctg tgc cgc cag tgg ctg atg cct gag     1599
 Thr Leu Ala Arg Leu His Glu Leu Cys Arg Gln Trp Leu Met Pro Glu
             415                 420                 425

 gcg cgc tcc aag gag cag atg ctg gag ctg ctg gtg ctg gag cag ttc     1647
 Ala Arg Ser Lys Glu Gln Met Leu Glu Leu Leu Val Leu Glu Gln Phe
         430                 435                 440

 ctg ggc atc ctg cct gat aag gtc cgg ccc tgg gtg gtg gca cag tac     1695
 Leu Gly Ile Leu Pro Asp Lys Val Arg Pro Trp Val Val Ala Gln Tyr
     445                 450                 455

 cct gag agc tgc aag aag gca gcc tcc ctg gtg gag ggc ctc gct gat     1743
 Pro Glu Ser Cys Lys Lys Ala Ala Ser Leu Val Glu Gly Leu Ala Asp
 460                 465                 470                 475

 gtc ctg gaa gag cca ggg atg ctg ctg ggc tcc cct gcg ggc tca tcc     1791
 Val Leu Glu Glu Pro Gly Met Leu Leu Gly Ser Pro Ala Gly Ser Ser
                 480                 485                 490

 tca att ctt agc gat gga gtg tac gag agg cac atg gac cct ctg ctg     1839
 Ser Ile Leu Ser Asp Gly Val Tyr Glu Arg His Met Asp Pro Leu Leu
             495                 500                 505

 cta cca ggc gag ctc gcg agc ccc agc cag gcc ctt gga gct ggg gag     1887
 Leu Pro Gly Glu Leu Ala Ser Pro Ser Gln Ala Leu Gly Ala Gly Glu
         510                 515                 520

 atc ccg gca cct tct gag aca ccc tgg ctt tct ccg gac ccc ctg ttt     1935
 Ile Pro Ala Pro Ser Glu Thr Pro Trp Leu Ser Pro Asp Pro Leu Phe
     525                 530                 535

 ctg gaa cag agg agg gtc aga gaa gca aag acc gaa gag gac ggc cct     1983
 Leu Glu Gln Arg Arg Val Arg Glu Ala Lys Thr Glu Glu Asp Gly Pro
 540                 545                 550                 555

 gcc aac acc gag cag aag ctg aag tcc ttt cca gag gac cct cag cac     2031
 Ala Asn Thr Glu Gln Lys Leu Lys Ser Phe Pro Glu Asp Pro Gln His
                 560                 565                 570

 ctg ggg gag tgg ggc cac ctg gac cct gcc gag gag aac ctg aag agc     2079
 Leu Gly Glu Trp Gly His Leu Asp Pro Ala Glu Glu Asn Leu Lys Ser
             575                 580                 585

 tac cgg aag ctg ctc ctg tgg ggg tat cag ctt tcc cag cct gac gct     2127
 Tyr Arg Lys Leu Leu Leu Trp Gly Tyr Gln Leu Ser Gln Pro Asp Ala
         590                 595                 600

 gcc tcc agg ctg gac act gag gaa ctc cgg ttg gtg gaa aga gat cca     2175
 Ala Ser Arg Leu Asp Thr Glu Glu Leu Arg Leu Val Glu Arg Asp Pro
     605                 610                 615

 caa gga agc agc ctc cca gaa ggc ggg agg cgg cag gag agc gct ggg     2223
 Gln Gly Ser Ser Leu Pro Glu Gly Gly Arg Arg Gln Glu Ser Ala Gly
 620                 625                 630                 635

 tgc gcc tgc gag gag gcc gcc ccc gcg ggg gtg ctg cct gag ctg cct     2271
 Cys Ala Cys Glu Glu Ala Ala Pro Ala Gly Val Leu Pro Glu Leu Pro
                 640                 645                 650

 acg gag gcg ccc cct ggg gac gcc ctt gcc gat ccc ccg tcg ggc acc     2319
 Thr Glu Ala Pro Pro Gly Asp Ala Leu Ala Asp Pro Pro Ser Gly Thr
             655                 660                 665

 act gag gag gag gaa gag cag cct ggg aag gcc ccg gac ccg cag gac     2367
 Thr Glu Glu Glu Glu Glu Gln Pro Gly Lys Ala Pro Asp Pro Gln Asp
         670                 675                 680

 ccc cag gac gcg gag tcc gac tct gcc acc gga tcg cag agg cag tcc     2415
 Pro Gln Asp Ala Glu Ser Asp Ser Ala Thr Gly Ser Gln Arg Gln Ser
     685                 690                 695

 gtc atc cag cag cct gcc ccg gac agg ggc acg gcg aaa ctg gga acc     2463
 Val Ile Gln Gln Pro Ala Pro Asp Arg Gly Thr Ala Lys Leu Gly Thr
 700                 705                 710                 715

 aag agg ccg cac ccc gag gat ggt gac gag cag agc ctc gag ggc gtc     2511
 Lys Arg Pro His Pro Glu Asp Gly Asp Glu Gln Ser Leu Glu Gly Val
                 720                 725                 730

 tct agc tcc agc gac agc gca ggg ctg gag gcc ggg cag ggc cct ggg     2559
 Ser Ser Ser Ser Asp Ser Ala Gly Leu Glu Ala Gly Gln Gly Pro Gly
             735                 740                 745

 gct gac gag ccg ggc ttg tcc cgc ggg aag ccc tat gcc tgc ggc gag     2607
 Ala Asp Glu Pro Gly Leu Ser Arg Gly Lys Pro Tyr Ala Cys Gly Glu
         750                 755                 760

 tgc ggg gag gcc ttc gcg tgg ctc tcg cac ctg atg gag cac cac agc     2655
 Cys Gly Glu Ala Phe Ala Trp Leu Ser His Leu Met Glu His His Ser
     765                 770                 775

 agc cat ggc ggc cgg aag cgc tac gcc tgt cag ggc tgc tgg aag acc     2703
 Ser His Gly Gly Arg Lys Arg Tyr Ala Cys Gln Gly Cys Trp Lys Thr
 780                 785                 790                 795

 ttc cac ttc agc ctg gcc cta gcc gag cac cag aag acc cac gag aag     2751
 Phe His Phe Ser Leu Ala Leu Ala Glu His Gln Lys Thr His Glu Lys
                 800                 805                 810

 gag aaa agc tac gcg ctg ggg ggc gcc cgg ggc ccc caa ccg tcc acc     2799
 Glu Lys Ser Tyr Ala Leu Gly Gly Ala Arg Gly Pro Gln Pro Ser Thr
             815                 820                 825

 cgc gaa gcc cag gcg ggg gct agg gcg ggc ggt ccc cca gag agc gtg     2847
 Arg Glu Ala Gln Ala Gly Ala Arg Ala Gly Gly Pro Pro Glu Ser Val
         830                 835                 840

 gag ggc gag gct ccc ccc gca ccc cca gag gcg cag agg tga             2889
 Glu Gly Glu Ala Pro Pro Ala Pro Pro Glu Ala Gln Arg 
     845                 850                 855





      <210> 394
      <211> 1974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(1824)

      <400> 394
 aaaggtctct gaggcggcgg cggcggcggg gatcgtctcc ggcactggcg cacc  atg      57
                                                              Met
                                                                1

 tcg gtc agt gtc cat gag acc cgc aag tcg cgg agc agc acg ggg tcc      105
 Ser Val Ser Val His Glu Thr Arg Lys Ser Arg Ser Ser Thr Gly Ser
               5                  10                  15

 atg aac gtc acc ctc ttc cac aag gcc tcc cac ccg gac tgt gtg ctg      153
 Met Asn Val Thr Leu Phe His Lys Ala Ser His Pro Asp Cys Val Leu
          20                  25                  30

 gcc cac ctc aac acg ctt cgc aag cac tgc atg ttc acc gac gtc aca      201
 Ala His Leu Asn Thr Leu Arg Lys His Cys Met Phe Thr Asp Val Thr
      35                  40                  45

 ctc tgg gcg ggc gac cgt gcc ttc ccc tgt cac cgt gcc gtg ctg gcc      249
 Leu Trp Ala Gly Asp Arg Ala Phe Pro Cys His Arg Ala Val Leu Ala
  50                  55                  60                  65

 gcc tct agc cgc tat ttt gag gcc atg ttc agc cat ggc ctt cgg gag      297
 Ala Ser Ser Arg Tyr Phe Glu Ala Met Phe Ser His Gly Leu Arg Glu
                  70                  75                  80

 agc cgg gat gac act gtc aac ttc cag gac aac ctg cac ccg gag gtg      345
 Ser Arg Asp Asp Thr Val Asn Phe Gln Asp Asn Leu His Pro Glu Val
              85                  90                  95

 ctg gag ctg ctg ctg gac ttt gcc tac tcc tca cgc atc gcc atc aac      393
 Leu Glu Leu Leu Leu Asp Phe Ala Tyr Ser Ser Arg Ile Ala Ile Asn
         100                 105                 110

 gag gag aac gct gag tca ctg ctg gag gca ggc gac atg ctg cag ttc      441
 Glu Glu Asn Ala Glu Ser Leu Leu Glu Ala Gly Asp Met Leu Gln Phe
     115                 120                 125

 cac gat gtg cgg gat gct gcc gcc gag ttc ctg gag aag aac ctt ttc      489
 His Asp Val Arg Asp Ala Ala Ala Glu Phe Leu Glu Lys Asn Leu Phe
 130                 135                 140                 145

 ccc tcc aac tgc ctg ggc atg atg ctg ctc tcg gac gcc cac cag tgc      537
 Pro Ser Asn Cys Leu Gly Met Met Leu Leu Ser Asp Ala His Gln Cys
                 150                 155                 160

 cgc cgg ctg tat gag ttc tcc tgg cgc atg tgc ctg gtg cac ttt gag      585
 Arg Arg Leu Tyr Glu Phe Ser Trp Arg Met Cys Leu Val His Phe Glu
             165                 170                 175

 acg gtg agg cag agc gag gac ttc aac agc ctg tcc aag gac aca ctg      633
 Thr Val Arg Gln Ser Glu Asp Phe Asn Ser Leu Ser Lys Asp Thr Leu
         180                 185                 190

 ctg gac ctc atc tcg agt gat gag ctg gag acc gag gac gag cgg gtg      681
 Leu Asp Leu Ile Ser Ser Asp Glu Leu Glu Thr Glu Asp Glu Arg Val
     195                 200                 205

 gtc ttc gag gcc atc ctc cag tgg gtg aag cac gac ctg gag cca cgg      729
 Val Phe Glu Ala Ile Leu Gln Trp Val Lys His Asp Leu Glu Pro Arg
 210                 215                 220                 225

 aag gtc cac ttg ccc gag ctc ctc cgc agc gtg cgt ctg gcc ttg ctg      777
 Lys Val His Leu Pro Glu Leu Leu Arg Ser Val Arg Leu Ala Leu Leu
                 230                 235                 240

 ccg tcc gac tgc ctg cag gag gcc gtc tcc agc gag gcc ctc ctc atg      825
 Pro Ser Asp Cys Leu Gln Glu Ala Val Ser Ser Glu Ala Leu Leu Met
             245                 250                 255

 gca gac gag cgc acc aag ctt atc atg gat gag gcc ctg cgc tgc aag      873
 Ala Asp Glu Arg Thr Lys Leu Ile Met Asp Glu Ala Leu Arg Cys Lys
         260                 265                 270

 acc agg atc ctg cag aat gat ggc gtg gtc acc agc ccc tgt gcc cgg      921
 Thr Arg Ile Leu Gln Asn Asp Gly Val Val Thr Ser Pro Cys Ala Arg
     275                 280                 285

 cca cgc aag gcg ggc cac acg cta ctc atc ctg ggg ggc cag acc ttc      969
 Pro Arg Lys Ala Gly His Thr Leu Leu Ile Leu Gly Gly Gln Thr Phe
 290                 295                 300                 305

 atg tgt gac aag atc tac cag gtg gac cac aag gcc aag gag atc atc     1017
 Met Cys Asp Lys Ile Tyr Gln Val Asp His Lys Ala Lys Glu Ile Ile
                 310                 315                 320

 ccc aag gcc gac ctg ccc agc ccc cgg aag gag ttc agc gcc tca gcg     1065
 Pro Lys Ala Asp Leu Pro Ser Pro Arg Lys Glu Phe Ser Ala Ser Ala
             325                 330                 335

 atc ggc tgc aag gtc tat gtg acg ggg ggc agg ggc tcc gag aac ggg     1113
 Ile Gly Cys Lys Val Tyr Val Thr Gly Gly Arg Gly Ser Glu Asn Gly
         340                 345                 350

 gtc tcc aag gat gtc tgg gtg tac gac acc gta cat gag gaa tgg tcc     1161
 Val Ser Lys Asp Val Trp Val Tyr Asp Thr Val His Glu Glu Trp Ser
     355                 360                 365

 aag gcg gcg ccc atg ctg att gcc cgc ttt ggc cat ggc tca gct gag     1209
 Lys Ala Ala Pro Met Leu Ile Ala Arg Phe Gly His Gly Ser Ala Glu
 370                 375                 380                 385

 ctg gag aac tgc ctc tat gtg gtg ggg gga cac aca tcc ctg gca ggg     1257
 Leu Glu Asn Cys Leu Tyr Val Val Gly Gly His Thr Ser Leu Ala Gly
                 390                 395                 400

 gtc ttc ccg gcc tcg cct tct gtc tcc ctg aaa caa gtg gag aaa tac     1305
 Val Phe Pro Ala Ser Pro Ser Val Ser Leu Lys Gln Val Glu Lys Tyr
             405                 410                 415

 gac cct ggg gcc aac aag tgg atg atg gtg gcc ccc ttg cgg gat ggc     1353
 Asp Pro Gly Ala Asn Lys Trp Met Met Val Ala Pro Leu Arg Asp Gly
         420                 425                 430

 gtc agc aat gcc gca gtg gtg agt gcc aag ctg aag ctc ttt gtt ttc     1401
 Val Ser Asn Ala Ala Val Val Ser Ala Lys Leu Lys Leu Phe Val Phe
     435                 440                 445

 gga gga acc agc atc cac cgg gac atg gtg tcc aag gtc cag tgc tat     1449
 Gly Gly Thr Ser Ile His Arg Asp Met Val Ser Lys Val Gln Cys Tyr
 450                 455                 460                 465

 gac ccc tcg gag aac agg tgg acg atc aag gcc gag tgc ccc cag cct     1497
 Asp Pro Ser Glu Asn Arg Trp Thr Ile Lys Ala Glu Cys Pro Gln Pro
                 470                 475                 480

 tgg cgg tac aca gcc gct gcc gtc ctg ggc agc cag atc ttc atc atg     1545
 Trp Arg Tyr Thr Ala Ala Ala Val Leu Gly Ser Gln Ile Phe Ile Met
             485                 490                 495

 gga ggt gac acg gaa ttc aca gcc gcc tcg gcc tac cgc ttt gac tgt     1593
 Gly Gly Asp Thr Glu Phe Thr Ala Ala Ser Ala Tyr Arg Phe Asp Cys
         500                 505                 510

 gag acc aac cag tgg acg cgg att ggg gac atg act gcc aag cgc atg     1641
 Glu Thr Asn Gln Trp Thr Arg Ile Gly Asp Met Thr Ala Lys Arg Met
     515                 520                 525

 tcc tgc cat gcc ctg gct tcc ggc aac aag ctc tat gtg gtc ggg ggc     1689
 Ser Cys His Ala Leu Ala Ser Gly Asn Lys Leu Tyr Val Val Gly Gly
 530                 535                 540                 545

 tac ttt ggg acc cag agg tgt aag act ctg gac tgc tat gac ccc act     1737
 Tyr Phe Gly Thr Gln Arg Cys Lys Thr Leu Asp Cys Tyr Asp Pro Thr
                 550                 555                 560

 tca gat aca tgg aac tgc atc acc aca gtg ccc tac tca ctt atc ccc     1785
 Ser Asp Thr Trp Asn Cys Ile Thr Thr Val Pro Tyr Ser Leu Ile Pro
             565                 570                 575

 acg gcc ttt gtc agc acc tgg aag cac ctg ccc gcg tga caccagggcc      1834
 Thr Ala Phe Val Ser Thr Trp Lys His Leu Pro Ala 
         580                 585

 gcatccatct cagtgtggag gacagtgacg ggaccctcac catcctcttg cgttttggcc   1894

 cccatttgct ccctgagctc caagataaga atggccccga gagaactgct gaacatttgt   1954

 tcattgctgt cacctcctga                                               1974




      <210> 395
      <211> 1654
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (325)..(1611)

      <400> 395
 cgcatttggc cgaaactccc gggtcgacga ttcgtcgtgg actcctcccc acactgcagc     60

 gctcgccgcg cgcgcccatc gatcaggccc cctccctctg ccgcctcggc gcagactgct    120

 aagctcagca agtcttgcgg caaaggcact tcggagccga gttggggcag cggtggagcg    180

 gggacttcgc gcccccaggg gaacgggcgc ccctgcgaaa ccgtcgccag ccacgcgtcc    240

 ttgccgtccg acgccccctc acattggaga ccccggatct ctcccgcctc cttcgggtcg    300

 ctctccgctg tttcctctgc cacc   atg agg aac att ttc aag agg aac cag     351
                              Met Arg Asn Ile Phe Lys Arg Asn Gln
                                1               5

 gag cct att gtg gct cct gcc acc acc acc gcc acg atg ccc att gga      399
 Glu Pro Ile Val Ala Pro Ala Thr Thr Thr Ala Thr Met Pro Ile Gly
  10                  15                  20                  25

 ccc gtg gac aac tcc act gag agt ggg ggt gct ggg gag agc cag gag      447
 Pro Val Asp Asn Ser Thr Glu Ser Gly Gly Ala Gly Glu Ser Gln Glu
                  30                  35                  40

 gac atg ttt gcc aaa ctg aag gag aag tta ttc aat gag ata aac aag      495
 Asp Met Phe Ala Lys Leu Lys Glu Lys Leu Phe Asn Glu Ile Asn Lys
              45                  50                  55

 att ccc tta cca ccc tgg gca ctg atc gcc att gct gtg gtt gct ggg      543
 Ile Pro Leu Pro Pro Trp Ala Leu Ile Ala Ile Ala Val Val Ala Gly
          60                  65                  70

 ctc ctg ctt ctc acc tgc tgc ttc tgc atc tgc aag aaa tgc tgc tgc      591
 Leu Leu Leu Leu Thr Cys Cys Phe Cys Ile Cys Lys Lys Cys Cys Cys
      75                  80                  85

 aag aag aag aag aac aag aag gag aag ggc aaa ggc atg aag aat gcc      639
 Lys Lys Lys Lys Asn Lys Lys Glu Lys Gly Lys Gly Met Lys Asn Ala
  90                  95                 100                 105

 atg aac atg aag gac atg aaa ggg ggt cag ctc cca cag gat gac gac      687
 Met Asn Met Lys Asp Met Lys Gly Gly Gln Leu Pro Gln Asp Asp Asp
                 110                 115                 120

 gac gca gag aca ggc ctg act gag ggg gaa ggt gaa ggg gag gag gag      735
 Asp Ala Glu Thr Gly Leu Thr Glu Gly Glu Gly Glu Gly Glu Glu Glu
             125                 130                 135

 aaa gag cca gag aac ctg ggc aaa ctg cag ttt tcc ctg gac tat gat      783
 Lys Glu Pro Glu Asn Leu Gly Lys Leu Gln Phe Ser Leu Asp Tyr Asp
         140                 145                 150

 ttt cag gct aat cag ctt act gtg ggc gtt ctg cag gct gct gaa ctg      831
 Phe Gln Ala Asn Gln Leu Thr Val Gly Val Leu Gln Ala Ala Glu Leu
     155                 160                 165

 cct gcc ctg gac atg gga ggc acc tca gac cct tat gtc aag gtc ttc      879
 Pro Ala Leu Asp Met Gly Gly Thr Ser Asp Pro Tyr Val Lys Val Phe
 170                 175                 180                 185

 ctc ctt cct gac aag aag aag aaa tat gag acc aaa gtc cat cgg aag      927
 Leu Leu Pro Asp Lys Lys Lys Lys Tyr Glu Thr Lys Val His Arg Lys
                 190                 195                 200

 aca ctg aac cct gcc ttc aat gaa acc ttc acc ttc aag gtg ctg agg      975
 Thr Leu Asn Pro Ala Phe Asn Glu Thr Phe Thr Phe Lys Val Leu Arg
             205                 210                 215

 gct gga agg gtg cca tac cag gag ctt ggg ggc aaa act ctg gtg atg     1023
 Ala Gly Arg Val Pro Tyr Gln Glu Leu Gly Gly Lys Thr Leu Val Met
         220                 225                 230

 gcc atc tat gac ttt gac cgc ttc tcc aaa cat gac atc att gga gag     1071
 Ala Ile Tyr Asp Phe Asp Arg Phe Ser Lys His Asp Ile Ile Gly Glu
     235                 240                 245

 gta aag gtg cct atg aac aca gtg gac ctc ggc cag ccc att gag gag     1119
 Val Lys Val Pro Met Asn Thr Val Asp Leu Gly Gln Pro Ile Glu Glu
 250                 255                 260                 265

 tgg aga gac ctg caa ggc ggg gaa aag gag gag ccg gag aag ctg ggc     1167
 Trp Arg Asp Leu Gln Gly Gly Glu Lys Glu Glu Pro Glu Lys Leu Gly
                 270                 275                 280

 gac atc tgc acc tcc ctg cgc tat gtg ccc acg gcc ggg aag ctc act     1215
 Asp Ile Cys Thr Ser Leu Arg Tyr Val Pro Thr Ala Gly Lys Leu Thr
             285                 290                 295

 gtc tgc atc ctg gag gct aag aac ctc aag aag atg gac gtg ggc ggc     1263
 Val Cys Ile Leu Glu Ala Lys Asn Leu Lys Lys Met Asp Val Gly Gly
         300                 305                 310

 ctt tca gac ccg tac gtg aag atc cac ctg atg cag aat ggc aag agg     1311
 Leu Ser Asp Pro Tyr Val Lys Ile His Leu Met Gln Asn Gly Lys Arg
     315                 320                 325

 ctc aag aag aag aag aca acc gtg aag aag aag acc ctg aac cca tac     1359
 Leu Lys Lys Lys Lys Thr Thr Val Lys Lys Lys Thr Leu Asn Pro Tyr
 330                 335                 340                 345

 ttc aac gag tcc ttc agc ttt gag atc ccc ttc gag cag att cag aaa     1407
 Phe Asn Glu Ser Phe Ser Phe Glu Ile Pro Phe Glu Gln Ile Gln Lys
                 350                 355                 360

 gtc cag gta gtg gtc acc gtg ctg gac tat gac aag ctg ggc aag aac     1455
 Val Gln Val Val Val Thr Val Leu Asp Tyr Asp Lys Leu Gly Lys Asn
             365                 370                 375

 gaa gcc ata ggc aag atc ttc gtg ggc agc aat gcc acg ggc aca gag     1503
 Glu Ala Ile Gly Lys Ile Phe Val Gly Ser Asn Ala Thr Gly Thr Glu
         380                 385                 390

 ctg cgg cac tgg tcc gac atg ctg gcc aac ccc cgg agg ccc atc gcc     1551
 Leu Arg His Trp Ser Asp Met Leu Ala Asn Pro Arg Arg Pro Ile Ala
     395                 400                 405

 cag tgg cac tcg ctc aag cct gag gag gag gtg gat gca ctc ctg ggc     1599
 Gln Trp His Ser Leu Lys Pro Glu Glu Glu Val Asp Ala Leu Leu Gly
 410                 415                 420                 425

 aag aac aag tag aca gcagcggctg ggaccccaca cctttcacgg acactgacaa     1654
 Lys Asn Lys 






      <210> 396
      <211> 2266
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (204)..(2156)

      <400> 396
 tttcgtgggc ggcgccacct cgcgctccgc cgtggtcccg gcgccgggtc ccggagacag     60

 acgttacgcg ggctcgagcg tcctcgggga gtgccagcca gagttggtga cgaccacttc    120

 ctcgacgtgg ggcgggcgga cgggaagcct ggggtcgtgg ccaccgcctc gggagctctg    180

 ggagcccggg tgaccgcgta gaa    atg aac aca gaa gcg gag caa cag ctt     230
                              Met Asn Thr Glu Ala Glu Gln Gln Leu
                                1               5

 ctc cat cac gcc aga aat ggc aat gct gaa gaa gta aga caa cta tta      278
 Leu His His Ala Arg Asn Gly Asn Ala Glu Glu Val Arg Gln Leu Leu
  10                  15                  20                  25

 gag acc atg gcg agg aat gaa gtg att gct gac att aat tgc aaa gga      326
 Glu Thr Met Ala Arg Asn Glu Val Ile Ala Asp Ile Asn Cys Lys Gly
                  30                  35                  40

 aga agt aag tct aac ttg ggc tgg aca cct cta cat ctg gca tgc tat      374
 Arg Ser Lys Ser Asn Leu Gly Trp Thr Pro Leu His Leu Ala Cys Tyr
              45                  50                  55

 ttt gga cac aga caa gtg gtc cag gat ctg ttg aag gct ggt gca gaa      422
 Phe Gly His Arg Gln Val Val Gln Asp Leu Leu Lys Ala Gly Ala Glu
          60                  65                  70

 gtg aat gtg ttg aat gac atg gga gac acg ccg ctt cat cga gct gcc      470
 Val Asn Val Leu Asn Asp Met Gly Asp Thr Pro Leu His Arg Ala Ala
      75                  80                  85

 ttt aca gga cga aag gag ttg gta atg ctt ctc tta gaa tat aat gct      518
 Phe Thr Gly Arg Lys Glu Leu Val Met Leu Leu Leu Glu Tyr Asn Ala
  90                  95                 100                 105

 gat act act att gtt aat ggg agt gga cag aca gca aaa gaa gtt act      566
 Asp Thr Thr Ile Val Asn Gly Ser Gly Gln Thr Ala Lys Glu Val Thr
                 110                 115                 120

 cat gct gaa gaa atc aca agc atg ctt gaa gct gta gaa agg act caa      614
 His Ala Glu Glu Ile Thr Ser Met Leu Glu Ala Val Glu Arg Thr Gln
             125                 130                 135

 caa aga aag ctt gaa gaa tta ctt tta gca gca gca aga gaa ggc aaa      662
 Gln Arg Lys Leu Glu Glu Leu Leu Leu Ala Ala Ala Arg Glu Gly Lys
         140                 145                 150

 aca aca gaa ctc aca gct ctg ctc aac agg ccc aat cct cct gat gtt      710
 Thr Thr Glu Leu Thr Ala Leu Leu Asn Arg Pro Asn Pro Pro Asp Val
     155                 160                 165

 aac tgt tcg gat cag tta gga aat aca ccc ttg cat tgg gca gct tac      758
 Asn Cys Ser Asp Gln Leu Gly Asn Thr Pro Leu His Trp Ala Ala Tyr
 170                 175                 180                 185

 cgg gcc cat aaa caa tgg gcc tta aag ctt cta aga agt gga gca gac      806
 Arg Ala His Lys Gln Trp Ala Leu Lys Leu Leu Arg Ser Gly Ala Asp
                 190                 195                 200

 cct aat ctg aag aac aaa aat gat cag aaa cct ctt gac ctt gcc cag      854
 Pro Asn Leu Lys Asn Lys Asn Asp Gln Lys Pro Leu Asp Leu Ala Gln
             205                 210                 215

 ggt gct gaa atg aaa cac att ctt gtt ggt aat aag gtc atc tac aaa      902
 Gly Ala Glu Met Lys His Ile Leu Val Gly Asn Lys Val Ile Tyr Lys
         220                 225                 230

 gca ttg aaa cga tat gag ggc cct ctc tgg aag agt tca aga ttt ttt      950
 Ala Leu Lys Arg Tyr Glu Gly Pro Leu Trp Lys Ser Ser Arg Phe Phe
     235                 240                 245

 ggc tgg aga tta ttc tgg gta gtg tta gag cat gga gtc ctt tca tgg      998
 Gly Trp Arg Leu Phe Trp Val Val Leu Glu His Gly Val Leu Ser Trp
 250                 255                 260                 265

 tat agg aaa cag cct gat gca gtt cat aat att tat cgc cag gga tgc     1046
 Tyr Arg Lys Gln Pro Asp Ala Val His Asn Ile Tyr Arg Gln Gly Cys
                 270                 275                 280

 aaa cac ctg act caa gca gta tgc acg gta aaa tcc act gat agc tgc     1094
 Lys His Leu Thr Gln Ala Val Cys Thr Val Lys Ser Thr Asp Ser Cys
             285                 290                 295

 ctc ttc ttt att aaa tgc ttt gat gac acc att cat ggc ttc cgg gtt     1142
 Leu Phe Phe Ile Lys Cys Phe Asp Asp Thr Ile His Gly Phe Arg Val
         300                 305                 310

 cct aag aat agc ctt cag cag tca aga gag gac tgg ctg gaa gca ata     1190
 Pro Lys Asn Ser Leu Gln Gln Ser Arg Glu Asp Trp Leu Glu Ala Ile
     315                 320                 325

 gaa gaa cat tct gct tac agc act cac tac tgt tcc cag gac cag ctg     1238
 Glu Glu His Ser Ala Tyr Ser Thr His Tyr Cys Ser Gln Asp Gln Leu
 330                 335                 340                 345

 act gat gag gag gag gaa gat acg gtt tcc gct gca gac ctg aag aaa     1286
 Thr Asp Glu Glu Glu Glu Asp Thr Val Ser Ala Ala Asp Leu Lys Lys
                 350                 355                 360

 tca tta gag aaa gca cag tca tgc caa cag cga cta gat agg gaa att     1334
 Ser Leu Glu Lys Ala Gln Ser Cys Gln Gln Arg Leu Asp Arg Glu Ile
             365                 370                 375

 tcc aac ttt ctc aaa atg att aag gag tgt gac atg gct aaa gaa atg     1382
 Ser Asn Phe Leu Lys Met Ile Lys Glu Cys Asp Met Ala Lys Glu Met
         380                 385                 390

 ctt cca tca ttt ctt cag aaa gtt gaa gtt gtc tca gaa gct tct aga     1430
 Leu Pro Ser Phe Leu Gln Lys Val Glu Val Val Ser Glu Ala Ser Arg
     395                 400                 405

 gaa act tgt gta gct ttg act gat tgc ctt aat ctc ttc acc aaa caa     1478
 Glu Thr Cys Val Ala Leu Thr Asp Cys Leu Asn Leu Phe Thr Lys Gln
 410                 415                 420                 425

 gaa ggg gtg agg aat ttt aaa ttg gaa caa gag caa gaa aaa aac aaa     1526
 Glu Gly Val Arg Asn Phe Lys Leu Glu Gln Glu Gln Glu Lys Asn Lys
                 430                 435                 440

 atc ttg tca gaa gca ctg gag acg ctg gcc act gaa cat cat gaa tta     1574
 Ile Leu Ser Glu Ala Leu Glu Thr Leu Ala Thr Glu His His Glu Leu
             445                 450                 455

 gag cag tct ctg gtg aaa ggc tct cca ccc gcc agc atc ctt agc gag     1622
 Glu Gln Ser Leu Val Lys Gly Ser Pro Pro Ala Ser Ile Leu Ser Glu
         460                 465                 470

 gac gag ttc tat gat gcg ctg tca gat tcc gag tcc gaa agg tcc ctg     1670
 Asp Glu Phe Tyr Asp Ala Leu Ser Asp Ser Glu Ser Glu Arg Ser Leu
     475                 480                 485

 agt aga ttg gaa gca gtg aca gca cgc tcc ttt gaa gag gaa gga gag     1718
 Ser Arg Leu Glu Ala Val Thr Ala Arg Ser Phe Glu Glu Glu Gly Glu
 490                 495                 500                 505

 cat ttg ggc agt aga aaa cac aga atg tcc gaa gaa aaa gac tgt ggt     1766
 His Leu Gly Ser Arg Lys His Arg Met Ser Glu Glu Lys Asp Cys Gly
                 510                 515                 520

 ggc gga gat gct ctc tcc aat ggc atc aag aaa cac aga aca agt ttg     1814
 Gly Gly Asp Ala Leu Ser Asn Gly Ile Lys Lys His Arg Thr Ser Leu
             525                 530                 535

 cct tct cct atg ttt tcc aga aat gac ttc agt atc tgg agc atc ctc     1862
 Pro Ser Pro Met Phe Ser Arg Asn Asp Phe Ser Ile Trp Ser Ile Leu
         540                 545                 550

 aga aaa tgt att gga atg gaa cta tcc aag atc acg atg cca gtt ata     1910
 Arg Lys Cys Ile Gly Met Glu Leu Ser Lys Ile Thr Met Pro Val Ile
     555                 560                 565

 ttt aat gag cct ctg agc ttc cta cag cgc cta act gaa tac atg gag     1958
 Phe Asn Glu Pro Leu Ser Phe Leu Gln Arg Leu Thr Glu Tyr Met Glu
 570                 575                 580                 585

 cat act tac ctc atc cac aag gcc agt tca ctc tct gat cct gtg gaa     2006
 His Thr Tyr Leu Ile His Lys Ala Ser Ser Leu Ser Asp Pro Val Glu
                 590                 595                 600

 agg atg cag tgt gta gct gcg ttt gct gta tct gct gtt gct tct cag     2054
 Arg Met Gln Cys Val Ala Ala Phe Ala Val Ser Ala Val Ala Ser Gln
             605                 610                 615

 tgg gaa cgg act gga aaa cct ttc aac cca ctg ctg gga gag act tat     2102
 Trp Glu Arg Thr Gly Lys Pro Phe Asn Pro Leu Leu Gly Glu Thr Tyr
         620                 625                 630

 gaa tta gtg cga gat gac ctt gga ttt aga ctc atc tcc gaa cag aca     2150
 Glu Leu Val Arg Asp Asp Leu Gly Phe Arg Leu Ile Ser Glu Gln Thr
     635                 640                 645

 caa tga ggcatataca tggacaaatc ccacctgctg tgtgcataat atcattgtgg      2206
 Gln 
 650

 gtaaactgtg gatcgaacag tatggcaatg tggaaattat aaaccacaag actggggaca   2266




      <210> 397
      <211> 723
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (218)..(676)

      <400> 397
 ggggagcggc acagggcagc ctcatcagcg tcatgggtgg aagtggctgc ggctggccgc     60

 tcaccagaag cgtgtctccc tctgcaaggg gaaggacaag cccgatgctg agggatccaa    120

 ctctaaactt ctcagatact gtgaccatga ggacaagttc ctgcttcctc tggagaggca    180

 gctccacgag gccgcccgcc agaacaatgt cggcagg atg cag gag ctg att ggg     235
                                          Met Gln Glu Leu Ile Gly
                                            1               5

 agg agg gtt aac acc agg gcc aga aac cac gtg ggc agg gtg gcc ctg      283
 Arg Arg Val Asn Thr Arg Ala Arg Asn His Val Gly Arg Val Ala Leu
              10                  15                  20

 cac tgg gct gca ggt gca agg cac gag cag gct gtg cgt ctg ctt gtg      331
 His Trp Ala Ala Gly Ala Arg His Glu Gln Ala Val Arg Leu Leu Val
          25                  30                  35

 gag cac gag gct gct gtg gac gat gag gat gtg gtg ggg aac act gcc      379
 Glu His Glu Ala Ala Val Asp Asp Glu Asp Val Val Gly Asn Thr Ala
      40                  45                  50

 ctt cat ctg gct gct ggt cgg ggc cat atg gct gtg ctg cag cga ctt      427
 Leu His Leu Ala Ala Gly Arg Gly His Met Ala Val Leu Gln Arg Leu
  55                  60                  65                  70

 gtg gac atc ggg ctg gac ctg gag gag cag aat gcg gaa ggt ctg act      475
 Val Asp Ile Gly Leu Asp Leu Glu Glu Gln Asn Ala Glu Gly Leu Thr
                  75                  80                  85

 gcc ccg cat tcg gct gct gga gga tcc cac cct gac tgt gtg cag ctc      523
 Ala Pro His Ser Ala Ala Gly Gly Ser His Pro Asp Cys Val Gln Leu
              90                  95                 100

 ctc ctc agg gct ggg agc acc gtg aat gcc ctc acc cag aaa aac cta      571
 Leu Leu Arg Ala Gly Ser Thr Val Asn Ala Leu Thr Gln Lys Asn Leu
         105                 110                 115

 agc tgc ctt cac tat gca gcc ctc agt ggc tcg gag gat gtg tct cgg      619
 Ser Cys Leu His Tyr Ala Ala Leu Ser Gly Ser Glu Asp Val Ser Arg
     120                 125                 130

 gtc ctc atc cac gca gga ggc tgc gcc aac gtg gtt gat cat aca cca      667
 Val Leu Ile His Ala Gly Gly Cys Ala Asn Val Val Asp His Thr Pro
 135                 140                 145                 150

 gaa tcc tga tgccagc ccagtggtca aactaagaag ttttcctgtt accttcattt      723
 Glu Ser 






      <210> 398
      <211> 1183
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (318)..(962)

      <400> 398
 tttcgtggtt gcgctgggct ccgggagcgc cgatggcgtg actggccccg cgcggagcag     60

 cgacagtaag gctgtgtggg gggagctggg acctaagccg cgcgcacacc cctttctctg    120

 cgtctggtgg aggtgcacag aggcttttga gtcaggccca agcgcagcca ggtgacctcc    180

 ccgcggcctt tcaagcctga gctcggtgga cagctccctc tcccgtgagt cccgctgtcc    240

 tgtacgcgcc cggacgagcc ccgggctgcg caccccgcta ggagctgccc ggccagcccg    300

 cttctctgcc cggagcc   atg aat ctc agt agc gcc agt agc acg gag gaa     350
                      Met Asn Leu Ser Ser Ala Ser Ser Thr Glu Glu
                        1               5                  10

 aag gca gtg acg acc gtg ctc tgg ggc tgc gag ctc agt cag gag agg      398
 Lys Ala Val Thr Thr Val Leu Trp Gly Cys Glu Leu Ser Gln Glu Arg
              15                  20                  25

 cgg act tgg acc ttc aga ccc cag ctg gag ggg aag cag agc tgc agg      446
 Arg Thr Trp Thr Phe Arg Pro Gln Leu Glu Gly Lys Gln Ser Cys Arg
          30                  35                  40

 ctg ttg ctt cat acg att tgc ttg ggg gag aaa gcc aaa gag gag atg      494
 Leu Leu Leu His Thr Ile Cys Leu Gly Glu Lys Ala Lys Glu Glu Met
      45                  50                  55

 cat cgc gtg gag atc ctg ccc cca gca aac cag gag gac aag aag atg      542
 His Arg Val Glu Ile Leu Pro Pro Ala Asn Gln Glu Asp Lys Lys Met
  60                  65                  70                  75

 cag ccg gtc acc att gcc tca ctc cag gcc tca gtc ctc ccc atg gtc      590
 Gln Pro Val Thr Ile Ala Ser Leu Gln Ala Ser Val Leu Pro Met Val
                  80                  85                  90

 tcc atg gta gga gtg cag ctt tct ccc cca gtt act ttc cag ctc cgg      638
 Ser Met Val Gly Val Gln Leu Ser Pro Pro Val Thr Phe Gln Leu Arg
              95                 100                 105

 gct ggc tca gga ccc gtg ttc ctc agt ggc cag gaa cgt tat gaa gca      686
 Ala Gly Ser Gly Pro Val Phe Leu Ser Gly Gln Glu Arg Tyr Glu Ala
         110                 115                 120

 tca gac cta acc tgg gag gag gag gag gaa gaa gaa ggg gag gag gag      734
 Ser Asp Leu Thr Trp Glu Glu Glu Glu Glu Glu Glu Gly Glu Glu Glu
     125                 130                 135

 gaa gag gaa gag gaa gat gat gag gat gag gat gca gat ata tct ctg      782
 Glu Glu Glu Glu Glu Asp Asp Glu Asp Glu Asp Ala Asp Ile Ser Leu
 140                 145                 150                 155

 gag gag caa agc cct gtc aaa caa gtc aaa agg ctg gtg ccc cag aag      830
 Glu Glu Gln Ser Pro Val Lys Gln Val Lys Arg Leu Val Pro Gln Lys
                 160                 165                 170

 cag gcg agc gtg gct aag aaa aaa aag ctg gaa aaa gaa gaa gag gaa      878
 Gln Ala Ser Val Ala Lys Lys Lys Lys Leu Glu Lys Glu Glu Glu Glu
             175                 180                 185

 ata aga gcc agc gtt aga gac aag agc cct gtg aaa aag gcc aaa gcc      926
 Ile Arg Ala Ser Val Arg Asp Lys Ser Pro Val Lys Lys Ala Lys Ala
         190                 195                 200

 aca gcc aga gcc aag aag cca gga ttc aag aaa tga ggag ccacgccttg      976
 Thr Ala Arg Ala Lys Lys Pro Gly Phe Lys Lys 
     205                 210

 gggggcacgg tgcaaagtgg gccttccctg ggctgtgctg caggcacagg gtgcccctgt   1036

 ccagcccctc cacctgtgtc tgaatgcaac aggggtgttg cgggggcaac atgagagccc   1096

 ctcaccccca actctccact ttcaggaggc ccccagtgaa gagccccacc tcggggtcac   1156

 aataaagttg cctggtcagg aaaaaaa                                       1183




      <210> 399
      <211> 708
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (152)..(658)

      <400> 399
 cagtgagcta gcttctgagt tttcccttct ttttatactg ttttctgtgc tggctttttt     60

 gaatcttcct aatttttcat ctctttaaca aactcctatg aagttgaaac cgggaagttt    120

 gctctaacat ttccagagaa ggtattaagt c   atg atg cag gaa tct gcg aca     172
                                      Met Met Gln Glu Ser Ala Thr
                                        1               5

 gag aca ata agc aac agt tca atg aat caa aat gga atg agc act cta      220
 Glu Thr Ile Ser Asn Ser Ser Met Asn Gln Asn Gly Met Ser Thr Leu
          10                  15                  20

 agc agc caa tta gat gct ggc agc aga gat gga aga tca agt ggt gac      268
 Ser Ser Gln Leu Asp Ala Gly Ser Arg Asp Gly Arg Ser Ser Gly Asp
      25                  30                  35

 acc agc tct gaa gta agc aca gta gaa ctg ctg cat ctg caa caa cag      316
 Thr Ser Ser Glu Val Ser Thr Val Glu Leu Leu His Leu Gln Gln Gln
  40                  45                  50                  55

 cag gct ctc cag gca gca aga caa ctt ctt tta cag cag caa aca agt      364
 Gln Ala Leu Gln Ala Ala Arg Gln Leu Leu Leu Gln Gln Gln Thr Ser
                  60                  65                  70

 gga ttg aaa tct cct aag agc agt gat aaa cag aga cca ctg cag gaa      412
 Gly Leu Lys Ser Pro Lys Ser Ser Asp Lys Gln Arg Pro Leu Gln Glu
              75                  80                  85

 ttg ctt cca gaa aca aaa tta tgt atc tgt ggc cac tct tct ggt gat      460
 Leu Leu Pro Glu Thr Lys Leu Cys Ile Cys Gly His Ser Ser Gly Asp
          90                  95                 100

 ggg cat cct cac aac aca ttt gca gtg cct gtg tca gtg gcc atg atg      508
 Gly His Pro His Asn Thr Phe Ala Val Pro Val Ser Val Ala Met Met
     105                 110                 115

 act ccc cag gtg atc acc cct cag caa atg cag cag atc ctt cag caa      556
 Thr Pro Gln Val Ile Thr Pro Gln Gln Met Gln Gln Ile Leu Gln Gln
 120                 125                 130                 135

 caa gtc ctg tct cct cag cag cta caa gcc ctt ctc caa caa cag cag      604
 Gln Val Leu Ser Pro Gln Gln Leu Gln Ala Leu Leu Gln Gln Gln Gln
                 140                 145                 150

 gct gtc atg ctg cag cag gta atg tgg gtt acc tgc ttt ggt gtt cta      652
 Ala Val Met Leu Gln Gln Val Met Trp Val Thr Cys Phe Gly Val Leu
             155                 160                 165

 gca tga cttagaaggt gtgcacttat tttgaaagtg cagtgggcat atttgacaat       708
 Ala 






      <210> 400
      <211> 3974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(2463)

      <400> 400
  atg gaa gat aca gaa aat aac tgt tgg aag ata gat ttg gat cat att      48
  Met Glu Asp Thr Glu Asn Asn Cys Trp Lys Ile Asp Leu Asp His Ile
    1               5                  10                  15

 ttg aca cac cta tgg tgc caa gag gag gag ttt gtg ctt caa tcc aaa       96
 Leu Thr His Leu Trp Cys Gln Glu Glu Glu Phe Val Leu Gln Ser Lys
              20                  25                  30

 agc aac agg aaa cag ttg aag gat tct aca aag aaa tta aag gat gtt      144
 Ser Asn Arg Lys Gln Leu Lys Asp Ser Thr Lys Lys Leu Lys Asp Val
          35                  40                  45

 ctt gaa gaa ttc cat ggt aat ggt gtg ctt gca aag tat aat cct gaa      192
 Leu Glu Glu Phe His Gly Asn Gly Val Leu Ala Lys Tyr Asn Pro Glu
      50                  55                  60

 ggg aaa caa gac att ctt aac caa aca ata gat ttt gaa ggt ttc aaa      240
 Gly Lys Gln Asp Ile Leu Asn Gln Thr Ile Asp Phe Glu Gly Phe Lys
  65                  70                  75                  80

 cta ttc atg aag aca ttc ctg gaa gcc gag ctt cct gat gat ttc act      288
 Leu Phe Met Lys Thr Phe Leu Glu Ala Glu Leu Pro Asp Asp Phe Thr
                  85                  90                  95

 gca cac ctt ttc atg tca ttt agc aac aag ttt cct cat tct agt cca      336
 Ala His Leu Phe Met Ser Phe Ser Asn Lys Phe Pro His Ser Ser Pro
             100                 105                 110

 atg gta aaa agt aag cct gct ctc cta tca ggc ggt ctg aga atg aat      384
 Met Val Lys Ser Lys Pro Ala Leu Leu Ser Gly Gly Leu Arg Met Asn
         115                 120                 125

 aaa ggt gcc atc acc cct ccc cgg act act tct cct gca aat acg tgt      432
 Lys Gly Ala Ile Thr Pro Pro Arg Thr Thr Ser Pro Ala Asn Thr Cys
     130                 135                 140

 tcc cca gaa gta atc cat ctg aag gac att gtc tgt tac ctg tct ctg      480
 Ser Pro Glu Val Ile His Leu Lys Asp Ile Val Cys Tyr Leu Ser Leu
 145                 150                 155                 160

 ctt gaa aga gga aga cct gag gat aag ctt gag ttt atg ttt cgc ctt      528
 Leu Glu Arg Gly Arg Pro Glu Asp Lys Leu Glu Phe Met Phe Arg Leu
                 165                 170                 175

 tat gac acg gat ggg aat ggc ttc ctg gac agc tcg gag cta gaa aat      576
 Tyr Asp Thr Asp Gly Asn Gly Phe Leu Asp Ser Ser Glu Leu Glu Asn
             180                 185                 190

 atc atc agt cag atg atg cat gtt gca gaa tac ctt gag tgg gat gtc      624
 Ile Ile Ser Gln Met Met His Val Ala Glu Tyr Leu Glu Trp Asp Val
         195                 200                 205

 act gaa ctt aat cca atc ctc cat gaa atg atg gaa gaa att gac tat      672
 Thr Glu Leu Asn Pro Ile Leu His Glu Met Met Glu Glu Ile Asp Tyr
     210                 215                 220

 gat cat gat gga acc gtg tct ctg gag gaa tgg att caa gga gga atg      720
 Asp His Asp Gly Thr Val Ser Leu Glu Glu Trp Ile Gln Gly Gly Met
 225                 230                 235                 240

 aca acg att cca ctt ctt gtg ctc ctg ggc tta gaa aat aac gtg aag      768
 Thr Thr Ile Pro Leu Leu Val Leu Leu Gly Leu Glu Asn Asn Val Lys
                 245                 250                 255

 gat gat gga cag cac gtg tgg cga ctg aag cac ttt aac aaa cct gcc      816
 Asp Asp Gly Gln His Val Trp Arg Leu Lys His Phe Asn Lys Pro Ala
             260                 265                 270

 tat tgc aac ctt tgc ctg aac atg ctg att ggc gtg ggg aag cag ggc      864
 Tyr Cys Asn Leu Cys Leu Asn Met Leu Ile Gly Val Gly Lys Gln Gly
         275                 280                 285

 ctc tgc tgt tcc ttc tgc aag tac aca gtc cat gag cgc tgt gtg gct      912
 Leu Cys Cys Ser Phe Cys Lys Tyr Thr Val His Glu Arg Cys Val Ala
     290                 295                 300

 cga gca cct ccc tct tgc atc aag acc tat gtg aag tcc aaa agg aac      960
 Arg Ala Pro Pro Ser Cys Ile Lys Thr Tyr Val Lys Ser Lys Arg Asn
 305                 310                 315                 320

 act gat gtc atg cac cat tac tgg gtt gaa ggt aac tgc cca acc aag     1008
 Thr Asp Val Met His His Tyr Trp Val Glu Gly Asn Cys Pro Thr Lys
                 325                 330                 335

 tgt gat aag tgc cac aaa act gtt aaa tgt tac cag ggc ctg aca gga     1056
 Cys Asp Lys Cys His Lys Thr Val Lys Cys Tyr Gln Gly Leu Thr Gly
             340                 345                 350

 ctg cat tgt gtt tgg tgt cag atc aca ctg cat aat aaa tgt gct tct     1104
 Leu His Cys Val Trp Cys Gln Ile Thr Leu His Asn Lys Cys Ala Ser
         355                 360                 365

 cat cta aaa cct gaa tgt gac tgt gga cct ttg aag gac cat att tta     1152
 His Leu Lys Pro Glu Cys Asp Cys Gly Pro Leu Lys Asp His Ile Leu
     370                 375                 380

 cca ccc aca aca atc tgt cca gtg gta ctg cag act ctg ccc act tca     1200
 Pro Pro Thr Thr Ile Cys Pro Val Val Leu Gln Thr Leu Pro Thr Ser
 385                 390                 395                 400

 gga gtt tca gtt cct gag gaa aga caa tca aca gtg aaa aag gaa aag     1248
 Gly Val Ser Val Pro Glu Glu Arg Gln Ser Thr Val Lys Lys Glu Lys
                 405                 410                 415

 agt ggt tcc cag cag cca aac aaa gtg att gac aag aat aaa atg caa     1296
 Ser Gly Ser Gln Gln Pro Asn Lys Val Ile Asp Lys Asn Lys Met Gln
             420                 425                 430

 aga gcc aac tct gtt act gta gat gga caa ggc ctg cag gtc act cct     1344
 Arg Ala Asn Ser Val Thr Val Asp Gly Gln Gly Leu Gln Val Thr Pro
         435                 440                 445

 gtg cct ggt act cac cca ctt tta gtt ttt gtg aac ccc aaa agt ggt     1392
 Val Pro Gly Thr His Pro Leu Leu Val Phe Val Asn Pro Lys Ser Gly
     450                 455                 460

 gga aaa caa gga gaa cga att tac aga aaa ttc cag tat cta tta aat     1440
 Gly Lys Gln Gly Glu Arg Ile Tyr Arg Lys Phe Gln Tyr Leu Leu Asn
 465                 470                 475                 480

 cct cgt cag gtt tac agt ctt tct gga aat gga cca atg cca ggg tta     1488
 Pro Arg Gln Val Tyr Ser Leu Ser Gly Asn Gly Pro Met Pro Gly Leu
                 485                 490                 495

 aac ttt ttc cgt gat gtt cct gac ttc aga gtg tta gcc tgt ggt gga     1536
 Asn Phe Phe Arg Asp Val Pro Asp Phe Arg Val Leu Ala Cys Gly Gly
             500                 505                 510

 gat gga acc gtg ggc tgg gtt ttg gat tgc ata gaa aag gcc aat gta     1584
 Asp Gly Thr Val Gly Trp Val Leu Asp Cys Ile Glu Lys Ala Asn Val
         515                 520                 525

 ggc aag cat cct cca gtt gcg att ctg cct ctt ggg act ggc aat gat     1632
 Gly Lys His Pro Pro Val Ala Ile Leu Pro Leu Gly Thr Gly Asn Asp
     530                 535                 540

 cta gca aga tgc ctg cga tgg gga gga ggt tac gaa ggt gag aat ctg     1680
 Leu Ala Arg Cys Leu Arg Trp Gly Gly Gly Tyr Glu Gly Glu Asn Leu
 545                 550                 555                 560

 atg aaa att cta aaa gac att gaa aac agc aca gaa atc atg ttg gac     1728
 Met Lys Ile Leu Lys Asp Ile Glu Asn Ser Thr Glu Ile Met Leu Asp
                 565                 570                 575

 agg tgg aag ttt gaa gtc ata cct aat gac aaa gat gag aaa gga gac     1776
 Arg Trp Lys Phe Glu Val Ile Pro Asn Asp Lys Asp Glu Lys Gly Asp
             580                 585                 590

 cca gtg cct tac agt atc atc aat aat tac ttt tcc att ggc gtg gat     1824
 Pro Val Pro Tyr Ser Ile Ile Asn Asn Tyr Phe Ser Ile Gly Val Asp
         595                 600                 605

 gcc tcc att gca cac aga ttc cac atc atg aga gaa aaa cac cca gag     1872
 Ala Ser Ile Ala His Arg Phe His Ile Met Arg Glu Lys His Pro Glu
     610                 615                 620

 aaa ttc aac agt aga atg aag aac aaa ttt tgg tat ttt gag ttt ggc     1920
 Lys Phe Asn Ser Arg Met Lys Asn Lys Phe Trp Tyr Phe Glu Phe Gly
 625                 630                 635                 640

 aca tct gaa act ttc tca gcc acc tgc aag aag cta cat gaa tct gta     1968
 Thr Ser Glu Thr Phe Ser Ala Thr Cys Lys Lys Leu His Glu Ser Val
                 645                 650                 655

 gaa ata gaa tgt gat gga gta cag ata gat tta ata aac atc tct ctg     2016
 Glu Ile Glu Cys Asp Gly Val Gln Ile Asp Leu Ile Asn Ile Ser Leu
             660                 665                 670

 gaa gga att gct att ttg aat ata cca agc atg cat gga gga tcc aat     2064
 Glu Gly Ile Ala Ile Leu Asn Ile Pro Ser Met His Gly Gly Ser Asn
         675                 680                 685

 ctt tgg gga gag tct aag aaa aga cga agc cat cga cga ata gag aaa     2112
 Leu Trp Gly Glu Ser Lys Lys Arg Arg Ser His Arg Arg Ile Glu Lys
     690                 695                 700

 aaa ggg tct gac aaa agg acc acc gtc aca gat gcc aaa gag ttg aag     2160
 Lys Gly Ser Asp Lys Arg Thr Thr Val Thr Asp Ala Lys Glu Leu Lys
 705                 710                 715                 720

 ttt gca agt caa gat ctc agt gac cag ctg ctg gag gtg gtc ggc ttg     2208
 Phe Ala Ser Gln Asp Leu Ser Asp Gln Leu Leu Glu Val Val Gly Leu
                 725                 730                 735

 gaa gga gcc atg gag atg ggg caa ata tac aca ggc ctg aaa agt gct     2256
 Glu Gly Ala Met Glu Met Gly Gln Ile Tyr Thr Gly Leu Lys Ser Ala
             740                 745                 750

 ggc cgg cgg ctg gct cag tgc tcc tgc gtg gtc atc agg acg agc aag     2304
 Gly Arg Arg Leu Ala Gln Cys Ser Cys Val Val Ile Arg Thr Ser Lys
         755                 760                 765

 tct ctg cca atg caa att gat ggg gag cca tgg atg cag acc cca tgc     2352
 Ser Leu Pro Met Gln Ile Asp Gly Glu Pro Trp Met Gln Thr Pro Cys
     770                 775                 780

 aca ata aaa att aca cac aag aac caa gcc cca atg ctg atg ggc ccg     2400
 Thr Ile Lys Ile Thr His Lys Asn Gln Ala Pro Met Leu Met Gly Pro
 785                 790                 795                 800

 cct cca aaa acc ggt tta ttc tgc tcc ctc gtc aaa agg aca aga aac     2448
 Pro Pro Lys Thr Gly Leu Phe Cys Ser Leu Val Lys Arg Thr Arg Asn
                 805                 810                 815

 cga agc aag gaa taa tcctgtgttg tttcactctt agaaattgaa ttagcataat     2503
 Arg Ser Lys Glu 
             820

 tgggccatgg aacacatatg ctggaaatct ttgaaccatt tcaagtctcc tgctcatgca   2563

 aaatcatgga agtggtttaa cagtttttgt tactaagcta atgtaaaatt cagctattag   2623

 aaaatttatt gtctcagttt ttataggcat ctttgcatga agaaagcaga agtttacctg   2683

 aagtgatact gcatattttt ggtgcatgca ttcccataga tttttacatc tcccacccaa   2743

 ctcttcccca atttcctttt actaacctgt gagaaaaacc cgtgaaacat gaaaaaggaa   2803

 ataccatggg aaacgtgatt ctcagtgtga ttccaattat tacgaagcac taatcagtaa   2863

 cgctacaatg atcataattg cagattgcta tacgtttccc ttttagaatc agtgtatcag   2923

 tgacctatga cttgaggaga aacttttaat tcgaagattt tattaaatag ttgactacaa   2983

 taccttgcta tatatacata gtttttcttc aacatcttaa ctcttctgag tggaaataaa   3043

 aatatcaggc ataaggtttt ctcatgctga aaaatagaac gcggttttta ttttgcttag   3103

 ttttcttttt aattccagaa ataagtgaaa acatgttact tgacagtcaa gtgtggtaat   3163

 atggcaagcc ttgttccttt ctgcatgaga atctaggaga gaattcataa ccacaccaat   3223

 aacgaaatag aagttttaaa ctatgtgcct aatcaatgtg tttcccacca aagattcaga   3283

 aaacaatgct tgagagaaat gggttaatgc ataattaatt aagcattgtg gagcaaattt   3343

 agggttcctg tgattaattt tgtgatgact aaaatgctgg aaagcaagtg agttgcccat   3403

 taattatgat taaaattctc acctttcaca gacagacaat aagccagaca acacaatcaa   3463

 agctcaatag atgatttctt gcttttttca gtcatttata aatataggtg taatttttca   3523

 tggatcagtt aagtacactt gaaggaagta aatgattgta tcagtttatt tctagtataa   3583

 atgggtacct gtaataatac tgagctcttg gaagcgaatc atgcatgcaa ttagctccct   3643

 cctcctcacc tactccactc ccatctttat gacatttcaa atgtttattt ggaaacaaca   3703

 gcctagatca ctgttgaagg tgttcatggc atagttggag tctctgactg tttaaagaaa   3763

 tcacagaaca gtacttttct tttagtgttt cattaagcct atgatgtaaa atgaaatgct   3823

 tctgagcagt cttgtaatat tgttcattca tattgacctg catctcatca ttgcatgttt   3883

 tatgttttca aacatgccat aaggaaaacg agtgcctgaa ctgcatgatt tattagtttc   3943

 tctccactct gcattaaagt gctaatgatt t                                  3974




      <210> 401
      <211> 1348
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (194)..(1285)

      <400> 401
 agccttcgcg ataaacgggc tgtcctacgg gctgctgcgc tcgctgggcc ttgccttccc     60

 tgaccttgcc gagcactttg accgaagcgc ccaggacact gcgtggatca gcgccctggc    120

 cctggccgtg cagcaggcag ccagccccgt gggcagcgcc ctgagcacgc gctggggggc    180

 ccgccccgtg gtg   atg gtt ggg ggc gtc ctc gcc tcg ctg ggc ttc gtc     229
                  Met Val Gly Gly Val Leu Ala Ser Leu Gly Phe Val
                    1               5                  10

 ttc tcg gct ttc gcc agc gat ctg ctg cat ctc tac ctc ggc ctg ggc      277
 Phe Ser Ala Phe Ala Ser Asp Leu Leu His Leu Tyr Leu Gly Leu Gly
          15                  20                  25

 ctc ctc gct ggc ttt ggt tgg gcc ctg gtg ttc gcc ccc gcc cta ggc      325
 Leu Leu Ala Gly Phe Gly Trp Ala Leu Val Phe Ala Pro Ala Leu Gly
      30                  35                  40

 acc ctc tcg cgt tac ttc tcc cgc cgt cga gtc ttg gcg gtg ggg ctg      373
 Thr Leu Ser Arg Tyr Phe Ser Arg Arg Arg Val Leu Ala Val Gly Leu
  45                  50                  55                  60

 gcg ctc acc ggc aac ggg gcc tcc tcg ctg ctc ctg gcg ccc gcc ttg      421
 Ala Leu Thr Gly Asn Gly Ala Ser Ser Leu Leu Leu Ala Pro Ala Leu
                  65                  70                  75

 cag ctt ctt ctc gat act ttc ggc tgg cgg ggc gct ctg ctc ctc ctc      469
 Gln Leu Leu Leu Asp Thr Phe Gly Trp Arg Gly Ala Leu Leu Leu Leu
              80                  85                  90

 ggc gcg atc acc ctc cac ctc acc ccc tgt ggc gcc ctg ctg cta ccc      517
 Gly Ala Ile Thr Leu His Leu Thr Pro Cys Gly Ala Leu Leu Leu Pro
          95                 100                 105

 ctg gtc ctt cct gga gac ccc cca gcc cca ccg cgt agt ccc cta gct      565
 Leu Val Leu Pro Gly Asp Pro Pro Ala Pro Pro Arg Ser Pro Leu Ala
     110                 115                 120

 gcc ctc ggc ctg agt ctg ttc aca cgc cgg gcc ttc tca atc ttt gct      613
 Ala Leu Gly Leu Ser Leu Phe Thr Arg Arg Ala Phe Ser Ile Phe Ala
 125                 130                 135                 140

 cta ggc aca gcc ctg gtt ggg ggc ggg tac ttc gtt cct tac gtg cac      661
 Leu Gly Thr Ala Leu Val Gly Gly Gly Tyr Phe Val Pro Tyr Val His
                 145                 150                 155

 ttg gct ccc cac gct tta gac cgg ggc ctg ggg gga tac gga gca gcg      709
 Leu Ala Pro His Ala Leu Asp Arg Gly Leu Gly Gly Tyr Gly Ala Ala
             160                 165                 170

 ctg gtg gtg gcc gtg gct gcg atg ggg gat gcg ggc gcc cgg ctg gtc      757
 Leu Val Val Ala Val Ala Ala Met Gly Asp Ala Gly Ala Arg Leu Val
         175                 180                 185

 tgc ggg tgg ctg gca gac caa ggc tgg gtg ccc ctc ccg cgg ctg ctg      805
 Cys Gly Trp Leu Ala Asp Gln Gly Trp Val Pro Leu Pro Arg Leu Leu
     190                 195                 200

 gcc gta ttc ggg gct ctg act ggg ctg ggg ctg tgg gtg gtg ggg ctg      853
 Ala Val Phe Gly Ala Leu Thr Gly Leu Gly Leu Trp Val Val Gly Leu
 205                 210                 215                 220

 gtg ccc gtg gtg ggc ggc gaa gag agc tgg ggg ggt ccc ctg ctg gcc      901
 Val Pro Val Val Gly Gly Glu Glu Ser Trp Gly Gly Pro Leu Leu Ala
                 225                 230                 235

 gcg gct gtg gcc tat ggg ctg agc gcg ggg agt tac gcc ccg ctg gtt      949
 Ala Ala Val Ala Tyr Gly Leu Ser Ala Gly Ser Tyr Ala Pro Leu Val
             240                 245                 250

 ttc ggt gta ctc ccc ggg ctg gtg ggc gtc gga ggt gtg gtg cag gcc      997
 Phe Gly Val Leu Pro Gly Leu Val Gly Val Gly Gly Val Val Gln Ala
         255                 260                 265

 aca ggg ctg gtg atg atg ctg atg agc ctc ggg ggg ctc ctg ggc cct     1045
 Thr Gly Leu Val Met Met Leu Met Ser Leu Gly Gly Leu Leu Gly Pro
     270                 275                 280

 ccc ctg tca ggc ttc cta agg gat gag aca gga gac ttc acc gcc tct     1093
 Pro Leu Ser Gly Phe Leu Arg Asp Glu Thr Gly Asp Phe Thr Ala Ser
 285                 290                 295                 300

 ttc ctc ctg tct ggt tct ttg atc ctc tcc ggc agc ttc atc tac ata     1141
 Phe Leu Leu Ser Gly Ser Leu Ile Leu Ser Gly Ser Phe Ile Tyr Ile
                 305                 310                 315

 ggg ttg ccc agg gcg ctg ccc tcc tgt ggt cca gcc tcc cct cca gcc     1189
 Gly Leu Pro Arg Ala Leu Pro Ser Cys Gly Pro Ala Ser Pro Pro Ala
             320                 325                 330

 acg cct ccc cca gag acg ggg gag ctg ctt ccc gct ccc cag gca gtc     1237
 Thr Pro Pro Pro Glu Thr Gly Glu Leu Leu Pro Ala Pro Gln Ala Val
         335                 340                 345

 ttg ctg tcc cca gga ggc cct ggc tcc act ctg gac acc act tgt tga     1285
 Leu Leu Ser Pro Gly Gly Pro Gly Ser Thr Leu Asp Thr Thr Cys 
     350                 355                 360

 ttattttctt gtttgagccc ctcccccaat aaagaatttt tatcgggttt taaaaaaaaa   1345

 aaa                                                                 1348




      <210> 402
      <211> 5967
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (4819)..(5967)

      <400> 402
 atggactcgg agtacgtcct atgctcttgg aaaggccgac tatggccagc aaaggttttg     60

 tgcacacgtg ggacttcacc aaaaacgaag cctgaaaagg cgatttctct agaagttcaa    120

 atcctcgcag tagatgaaaa aatcaaggtg aaaagcacag acgtgaagac cccaactaag    180

 tttgagatgg aagacattgc cgcctctgca gcagcacaga cgaagctcgg tgccccactc    240

 agagagaaga tggggtacag aggaaccctt cgggtggccc tggagattct gaaagagaga    300

 acaaatctgg gtggaggaag gaaaccacat gaactagaga gcaccacacc ctctcagctt    360

 tctcaaaagg tgcccgaaaa gccagccagt tctgtccctc gtgaagatga ctggagatgc    420

 aaaggcgacc taaggaggag tcttgggaag agggaaaacc caagctcacc gacggtccct    480

 tcagagagta agcgtgccct gcgggatgac aggtcgcagg agcccacagc cattgcccct    540

 actccaggcg ccctgcccgg ggacaggtca ggggcgccca gggccattgc ccctactcca    600

 ggagccatgc tcagtggcag gtcacgggca cgcagggcca ttgcccctac accaagcgcc    660

 ctgcgaggtt acaggtcttg ggcgcacagg gccattgccc ctaccccagg ctgcctgtac    720

 agtgacaggt cacgggcgca cagggccatt gcccctgctc gaggcaccaa gcatggtggc    780

 aggtcatggg catgcaggtc cattgccccc aaaccaggct ccctgtgcgg ggacaggtca    840

 caggcgagca gggccattga ccctacctta ggcgccaggc gcggtggcag gtcacgggcc    900

 cacagagcca ttgcccctac tccaggctcc ctgtgcggca acaggtcacg ggcttgcgga    960

 gccattgccc ttactccagg tgtcctgtgc ggtgtcaggt cacgggtgcc aaaggacatt   1020

 acccctactc caggcgccct gcgaggttac aagtcatggg tgtgcagggc cattgcccct   1080

 actccaggtg ccctgcgcgg agacaggtca gcagcacgca cggccattgt ccgtactcca   1140

 ggtgcccttg gcagggacag gtcacgggca cgcagcgcca ttgcttctac tccagggacc   1200

 ctgcagggaa acaggtcatc tgtgtccaag gccattgccc ctgctccagg tgccctgcgt   1260

 ggagacaggt cagcagcgcg cacggccttt gtccctactc caggcgccct tcacagggac   1320

 aggtcacggg cccgcagcgc cattgcttct actccaggga ccctgcgggg aaacacgtca   1380

 tctgcgtgca aggccattgc ccctactcca ggtgccctgc gaggttacaa gtcatgggcg   1440

 cgcagggcca ttgcacctaa cccaggtgcc tggcgcggtt acaggtcaac gacaggcacc   1500

 gccattgcac ctaatctggg cgccctgggc ggcaacaggt cagcggcacg cacggacatt   1560

 gcccctactc caggcgccct gcgaggttac aggtcatgga cgcgcagggc cattgcccct   1620

 actccaggca ctctgagcag ttacaggtca ccagtgcgca gggccattgc ccctactcca   1680

 ggcactctga gcggttacag gtcacgggca cgcacggcca ttgcccctac tccaggcacc   1740

 ctgcgaggtt acaggccacg gtcccgcagg gccattgcct ctactccagc caccctgcgt   1800

 ggtgaaaagt cacgggcgca caccagcctt gcccccgccc caggtgcttt gcgcggtgac   1860

 ggttcacgag cacgcagggc cattgtccct actacatgcc cattgtgcga gatatggtca   1920

 cgggtgggca taggcattgc ccctattgca gatgccctgc gccgtgacag gccaccagtg   1980

 cgcagggcca ttgctcctac tccaggcgcc ctgcgctgtg acaggtcacg agagctcaca   2040

 gccattgatc ctactccagg agctctgtgc agtgacaggt caggggcaag cagggccatt   2100

 gcccccactc caggcacttt gtgcagtgaa aggtcccggg tgcgcagggc cattgcccct   2160

 actccatgcg cactgtgcgg gaaggggtca caggtgggca tgggcgttgc ccctactcca   2220

 ggtgcactgc gcagggacag gtcacaggca ggcagggcca ttgcacctac tccatccgca   2280

 ctgttcaggg ttgggtcacg ggtgggcaca ggcattgccc ttcctgcagg tgccctgcac   2340

 cgtgacaggt caccggtgcg cagggccgtt gctcccactc caggcaccct gcactgtgac   2400

 gggtcacgaa aatgcacggc cactggttct actccaggag ccctgcccgg cgacaggtca   2460

 ggggtgagca aggccactgc ccctgctcca ggcgccttgt gcagtgaaag gtcccgcgca   2520

 cgcaggagca ttgcccctac tccatgttta ctgtgcgggg acaggtcatg ggtgggtatg   2580

 ggcattgcac ctactccagg cgccctgctt ggtggcaaat caaggaaatg cagggccatt   2640

 gctattactc ccggcgccct gcgtggtggc aggtcacaga aacgcagggt cgttgctcct   2700

 actccagagg ccctgcacgg tgacgggtca tggacttata tggccattgc tcctactcca   2760

 ggtgccctgc acggtgacag ctcaccagcc cacacgtcca ttattccctc tccaggcgcc   2820

 ctgcatggtg acgggccacc agcgcacatg gcctttcctt ctactccagg caccctgcat   2880

 ggtgatgcct ctcacgcaca catggccatt gctcctactc caggcacgat gcgcggtgac   2940

 agctcaacag cgcgcacggc cactgcccca tctccagggg ccctgcgagg tgacaggtca   3000

 tggaaacgca aggccattgc ttctactcca ggtgccctgc atggtaacag gtctgacagg   3060

 tcacggaaat gcaaggccat tgcttctact ccaggcaccc tgcacgttga gaggtcacca   3120

 gcactcaggg ccattgttcc aactccaggc accctgggcc gtgacagctc accagggcgc   3180

 acgtccatta ttccttctcc aggcgccctg catggtgaca ggtcaccagc acacctggac   3240

 attgcttcta ctccaggcgc cctgcacggt gacagctctc aggcacacac ggccattgct   3300

 cctactccag gcaccatgcg cggtgacagc tcaacagctc gcatggccat tgccccatct   3360

 gcaggggccc tgagaggtga caggtcatgg aaacgcaagg ccattgcttc tactccaggt   3420

 gccctgcgtg gtaacaggtc tgacaggtca cggaaacgca aagccattgc ttctactcca   3480

 ggtgccctgc tcggtaacag gtctgacagg tcacggaaac gcaaggccat tgctcctact   3540

 ccaggtgccc cgcgcattga caggtcacca gcatgcaggg ccattgctcc tactccaggc   3600

 gccctgggtg atgacagctc aacggccatt gcccctactc cagggacccc gcgaggtgac   3660

 agttcgccag caaacacggc cattgcttct actccaggcg ccctgcacgg tgacacctct   3720

 cagacacaca aggccattgc tcctactcca ggtgacctgg gcggtggcag ctcatcagcg   3780

 cacaaggcca tcgctccttc tccaggtgcc ctgcatggtg acaggtcacc agcacacacg   3840

 gccattgctt ctactccagg agccctgcat ggtgacagct cccaggtgca cacgaccatt   3900

 gctccaactc caggcgccct gcgcgatgac aagtcatgga aacgcaaggc cattgctccc   3960

 actccaggca ccctgcactg tgacagctca cgaacgtgca ccgcctttgc tcctactcca   4020

 ggcgccctgc atgctgacag gtcaccagcg caccaggaca ttactcttac ttcaggcgcc   4080

 ctgcactgtg acagctcaag agaaagcagg gccgttgctc ctattctagg cgccctgcac   4140

 cgtgtcggct ctcaggcaca caaggctatt gcttctactc caggccctct gcgcggtgac   4200

 agctcaccat ttcacacagc cattgcacct atgccagggg ccctgcatgg taccaggtca   4260

 tggaaacgcg aagccatttc tcagactcca ggcaccctgt gtggtgacag ctcaggagaa   4320

 cgcatggcca ttgctcctac tccaggcgcc ctgcacagtg acaggtcaca gacacatacg   4380

 gccatcgatc ctactccaag tgtcctgcgc agtgacagct caccagcgtg catggccatt   4440

 gatcctactc caggtgccct gggcagggac aggtcacagg cgctcatggc cattgctcct   4500

 actccagttg gaatgcaagc acatgtgttg caaagccccc gagcctgcca ggattccctg   4560

 acgctttcgc ggcatgtttg tgagaaaaag gggaagaaaa gggcaaacgc ctcaactctt   4620

 atgtccctgc ctcccacagt aacggaggag ggtgcatctc tgcctccagg tctcaccagc   4680

 cctgcacccc ccgctctgaa ggaagagaca caggacagcc gcccgaagaa ggccctggct   4740

 gcatccccgg aaagttctcc cttctcgggg aacattcagg accccggaga gggtgcctgg   4800

 aagccaggct gggcaggt  atg gct gca tcc tct ggg tcc cgt cag cac agg    4851
                      Met Ala Ala Ser Ser Gly Ser Arg Gln His Arg
                        1               5                  10

 ctg cct tct tca ctc cgg ctt gcc aat aga aaa agg aag cgt cca ggt     4899
 Leu Pro Ser Ser Leu Arg Leu Ala Asn Arg Lys Arg Lys Arg Pro Gly
              15                  20                  25

 cca gat ttt cag agg aga cct caa gga cct cag acg cct ggt gac gct     4947
 Pro Asp Phe Gln Arg Arg Pro Gln Gly Pro Gln Thr Pro Gly Asp Ala
          30                  35                  40

 aag ctt gct aat cct gtc acc acc att caa agg gct ggc ggt aaa cag     4995
 Lys Leu Ala Asn Pro Val Thr Thr Ile Gln Arg Ala Gly Gly Lys Gln
      45                  50                  55

 gat ggg cag ccc ccc agc ctt gct ttt cca cag gag cca cat ccc atc     5043
 Asp Gly Gln Pro Pro Ser Leu Ala Phe Pro Gln Glu Pro His Pro Ile
  60                  65                  70                  75

 gaa agg gga acg atg gtc tgg ttc aaa ttt caa gat cat ccg ttt tgg     5091
 Glu Arg Gly Thr Met Val Trp Phe Lys Phe Gln Asp His Pro Phe Trp
                  80                  85                  90

 cca gca gtg gtc aag agt gtc agc aac aca gac aag acc gcg agg gtg     5139
 Pro Ala Val Val Lys Ser Val Ser Asn Thr Asp Lys Thr Ala Arg Val
              95                 100                 105

 ctc ctg ctt gag gcc aac ctg cac cat gga aag cgg ggc att caa gtt     5187
 Leu Leu Leu Glu Ala Asn Leu His His Gly Lys Arg Gly Ile Gln Val
         110                 115                 120

 cct ctt cga agg ctg aag cac ctg gat tgt aag gag aaa gag aaa ctg     5235
 Pro Leu Arg Arg Leu Lys His Leu Asp Cys Lys Glu Lys Glu Lys Leu
     125                 130                 135

 ctg aag aga gcc cag aag gcc tac aag caa agc gtc aac tgg tgc ttc     5283
 Leu Lys Arg Ala Gln Lys Ala Tyr Lys Gln Ser Val Asn Trp Cys Phe
 140                 145                 150                 155

 tca ctg atc tcc cac tac aga gaa gga ctg gtc cgg ggt tct ttc cgg     5331
 Ser Leu Ile Ser His Tyr Arg Glu Gly Leu Val Arg Gly Ser Phe Arg
                 160                 165                 170

 ggc tct ttc ctg gac tat tat gcc gca gac atc agc tac cca atc agg     5379
 Gly Ser Phe Leu Asp Tyr Tyr Ala Ala Asp Ile Ser Tyr Pro Ile Arg
             175                 180                 185

 aga gcc atc caa gag gga gac ctg cag att gac ttt cca aag gtg aat     5427
 Arg Ala Ile Gln Glu Gly Asp Leu Gln Ile Asp Phe Pro Lys Val Asn
         190                 195                 200

 tat ggc gac ctg gaa gac tgg gag gag gag acc tcc ctg ggc ggg aag     5475
 Tyr Gly Asp Leu Glu Asp Trp Glu Glu Glu Thr Ser Leu Gly Gly Lys
     205                 210                 215

 agg cct tgc aag aaa atc ctc ccg gac cgg atg agg gcc tct tgg gac     5523
 Arg Pro Cys Lys Lys Ile Leu Pro Asp Arg Met Arg Ala Ser Trp Asp
 220                 225                 230                 235

 cga gac aac cag aag ctc gtg gac ttc atc gtg agg aga aag ggg gcc     5571
 Arg Asp Asn Gln Lys Leu Val Asp Phe Ile Val Arg Arg Lys Gly Ala
                 240                 245                 250

 gac ccc cac ctt ctg gac atc ttg caa ggc agg aag cag tcc agg tgg     5619
 Asp Pro His Leu Leu Asp Ile Leu Gln Gly Arg Lys Gln Ser Arg Trp
             255                 260                 265

 ctg acc gcg ttt ctg aag cca cac agg gat ttg cac tgc att gaa aca     5667
 Leu Thr Ala Phe Leu Lys Pro His Arg Asp Leu His Cys Ile Glu Thr
         270                 275                 280

 tac ctg gag gat gac gat cag ttg gaa gtc gtg gcc aag cat tta caa     5715
 Tyr Leu Glu Asp Asp Asp Gln Leu Glu Val Val Ala Lys His Leu Gln
     285                 290                 295

 gaa atc tac aag caa att gac aag gcc agg ctg act ctg ata agg gat     5763
 Glu Ile Tyr Lys Gln Ile Asp Lys Ala Arg Leu Thr Leu Ile Arg Asp
 300                 305                 310                 315

 gac aaa gtc aat ttt gtt ctg gaa gtt ctt ctg ccg gaa gcc atg att     5811
 Asp Lys Val Asn Phe Val Leu Glu Val Leu Leu Pro Glu Ala Met Ile
                 320                 325                 330

 tgt acc atc gcc gca ctt gat ggg ctg gat tac aag gca gca gag gag     5859
 Cys Thr Ile Ala Ala Leu Asp Gly Leu Asp Tyr Lys Ala Ala Glu Glu
             335                 340                 345

 aag tac ctg cga gga cca cct gtg cat tac cgg gag aaa gag ctg ttt     5907
 Lys Tyr Leu Arg Gly Pro Pro Val His Tyr Arg Glu Lys Glu Leu Phe
         350                 355                 360

 gac aga aat atc tta aag aag gca aga aga gaa cca gca acc acc cat     5955
 Asp Arg Asn Ile Leu Lys Lys Ala Arg Arg Glu Pro Ala Thr Thr His
     365                 370                 375

 aca gct aat tag                                                     5967
 Thr Ala Asn 
 380





      <210> 403
      <211> 2822
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(2822)

      <400> 403
 tgtcgttgtt ctgaggctag cagattcctt ctggacctgt agggtgccgc cctagcccag     60

 ccgcc    atg gcg cag ggt ttc gca gtg ggc ttc gac cca ctg ggc cta     107
          Met Ala Gln Gly Phe Ala Val Gly Phe Asp Pro Leu Gly Leu
            1               5                  10

 gga gac ctg agc tcc ggc tct ctg agc tcc ctc tcc tcc cga ggc cac      155
 Gly Asp Leu Ser Ser Gly Ser Leu Ser Ser Leu Ser Ser Arg Gly His
  15                  20                  25                  30

 cta ggc agc gac tca ggc tcc acc gca acg cga tac ctg cta agg aag      203
 Leu Gly Ser Asp Ser Gly Ser Thr Ala Thr Arg Tyr Leu Leu Arg Lys
                  35                  40                  45

 caa caa cgg ctg ctg aac ggg ccc ccc cgc gga atc cga gcc tca tcg      251
 Gln Gln Arg Leu Leu Asn Gly Pro Pro Arg Gly Ile Arg Ala Ser Ser
              50                  55                  60

 ccc atg gga cgc gtc atc ctc atc aac tcc ccc atc gaa gcc aac agt      299
 Pro Met Gly Arg Val Ile Leu Ile Asn Ser Pro Ile Glu Ala Asn Ser
          65                  70                  75

 gat gaa agt gac atc atc cat tca gtc cgg gtg gag aag agt cca gca      347
 Asp Glu Ser Asp Ile Ile His Ser Val Arg Val Glu Lys Ser Pro Ala
      80                  85                  90

 ggg agg ctg ggc ttc agc gtg cgc ggg ggc tca gag cat ggc ctg ggc      395
 Gly Arg Leu Gly Phe Ser Val Arg Gly Gly Ser Glu His Gly Leu Gly
  95                 100                 105                 110

 atc ttc gtc agc aaa gtg gag gaa ggc agc agt gca gag cgg gct ggc      443
 Ile Phe Val Ser Lys Val Glu Glu Gly Ser Ser Ala Glu Arg Ala Gly
                 115                 120                 125

 ctg tgc gtg ggg gac aag atc acg gag gtg aat ggg ctg agc ctg gag      491
 Leu Cys Val Gly Asp Lys Ile Thr Glu Val Asn Gly Leu Ser Leu Glu
             130                 135                 140

 agc acc acc atg ggt agc gcc gta aag gtg ctg acc agc agc agc cgc      539
 Ser Thr Thr Met Gly Ser Ala Val Lys Val Leu Thr Ser Ser Ser Arg
         145                 150                 155

 ctg cac atg atg gtt cgg cgc atg ggc cgt gtg ccg ggc atc aag ttc      587
 Leu His Met Met Val Arg Arg Met Gly Arg Val Pro Gly Ile Lys Phe
     160                 165                 170

 tcc aag gag aag acc acg tgg gtg gat gtg gtg aat cgg cgc ctg gta      635
 Ser Lys Glu Lys Thr Thr Trp Val Asp Val Val Asn Arg Arg Leu Val
 175                 180                 185                 190

 gtg gag aag tgc ggt tca aca ccc tcc gac acc agc tca gaa gat ggt      683
 Val Glu Lys Cys Gly Ser Thr Pro Ser Asp Thr Ser Ser Glu Asp Gly
                 195                 200                 205

 gtc cgg cgc atc gtc cac cta tac aca acc tcc gac gac ttc tgc ctg      731
 Val Arg Arg Ile Val His Leu Tyr Thr Thr Ser Asp Asp Phe Cys Leu
             210                 215                 220

 ggc ttc aac atc cgt ggg ggc aag gag ttt ggc ctg ggc atc tat gtg      779
 Gly Phe Asn Ile Arg Gly Gly Lys Glu Phe Gly Leu Gly Ile Tyr Val
         225                 230                 235

 tcc aaa gtg gac cat ggt ggg ctg gcc gag gag aat ggc atc aag gtg      827
 Ser Lys Val Asp His Gly Gly Leu Ala Glu Glu Asn Gly Ile Lys Val
     240                 245                 250

 ggg gac cag gtc ctg gca gcc aac ggt gtc agg ttt gac gac atc agc      875
 Gly Asp Gln Val Leu Ala Ala Asn Gly Val Arg Phe Asp Asp Ile Ser
 255                 260                 265                 270

 cac agc cag gcc gtg gag gtg ctg aag ggc caa acg cac atc atg ctg      923
 His Ser Gln Ala Val Glu Val Leu Lys Gly Gln Thr His Ile Met Leu
                 275                 280                 285

 acc atc aag gag acc ggc cgg tat cct gcc tac aag gag atg gtt tct      971
 Thr Ile Lys Glu Thr Gly Arg Tyr Pro Ala Tyr Lys Glu Met Val Ser
             290                 295                 300

 gag tac tgc tgg ctg gac cga ctg agc aac ggg gtg ctg cag cag ctg     1019
 Glu Tyr Cys Trp Leu Asp Arg Leu Ser Asn Gly Val Leu Gln Gln Leu
         305                 310                 315

 tcc ccg gcc tct gag agc agc tcc agc gtc tct tcg tgc gcc tcc agc     1067
 Ser Pro Ala Ser Glu Ser Ser Ser Ser Val Ser Ser Cys Ala Ser Ser
     320                 325                 330

 gcc ccc cac agc tcg ggc tcc ctg ccg tcg gac cgc atg gac atc tgc     1115
 Ala Pro His Ser Ser Gly Ser Leu Pro Ser Asp Arg Met Asp Ile Cys
 335                 340                 345                 350

 ctc ggg cag gag gag ccc ggc agc cgc ggc cca ggc tgg ggg cgg gcg     1163
 Leu Gly Gln Glu Glu Pro Gly Ser Arg Gly Pro Gly Trp Gly Arg Ala
                 355                 360                 365

 gac aca gcc atg cag acg gag ccc gat gcg gga ggc cgg gtg gag acc     1211
 Asp Thr Ala Met Gln Thr Glu Pro Asp Ala Gly Gly Arg Val Glu Thr
             370                 375                 380

 tgg tgc agc gtg cgg ccc aca gtc atc ctc agg gac acc gcc atc cgc     1259
 Trp Cys Ser Val Arg Pro Thr Val Ile Leu Arg Asp Thr Ala Ile Arg
         385                 390                 395

 tcg gac ggc ccc cat ccc ggc cgc cgc ctt gac tct gcg ctc tct gag     1307
 Ser Asp Gly Pro His Pro Gly Arg Arg Leu Asp Ser Ala Leu Ser Glu
     400                 405                 410

 tct ccc aag acg gct ttg ctg ctg gcc ctc agc cga ccc cgg ccc ccc     1355
 Ser Pro Lys Thr Ala Leu Leu Leu Ala Leu Ser Arg Pro Arg Pro Pro
 415                 420                 425                 430

 atc acg cgc tcc cag agc tat ctg acc ttg tgg gag gag aag cag cag     1403
 Ile Thr Arg Ser Gln Ser Tyr Leu Thr Leu Trp Glu Glu Lys Gln Gln
                 435                 440                 445

 cgg aag aag gag aag tcg ggg tcc cct ggg gag aag ggt gcc ctg cag     1451
 Arg Lys Lys Glu Lys Ser Gly Ser Pro Gly Glu Lys Gly Ala Leu Gln
             450                 455                 460

 cgc tcc aag acg ctg atg aac ctc ttc ttc aag gga ggg cgg cag ggg     1499
 Arg Ser Lys Thr Leu Met Asn Leu Phe Phe Lys Gly Gly Arg Gln Gly
         465                 470                 475

 agg cta gcg cgg gac ggg cgc aga gag gcc tgg aca ctg gac agc ggg     1547
 Arg Leu Ala Arg Asp Gly Arg Arg Glu Ala Trp Thr Leu Asp Ser Gly
     480                 485                 490

 agc ctg gcc aaa act tac cct cgc ctg gac ata gag aaa gac cag gag     1595
 Ser Leu Ala Lys Thr Tyr Pro Arg Leu Asp Ile Glu Lys Asp Gln Glu
 495                 500                 505                 510

 agg ggc cgg gcc ctg ctg tct gcc agg tct ggg agt ccc tcc agc cag     1643
 Arg Gly Arg Ala Leu Leu Ser Ala Arg Ser Gly Ser Pro Ser Ser Gln
                 515                 520                 525

 ctg cct aat gtg gat gag cag gtt cag gcc tgg gag agc cgg cgg ccc     1691
 Leu Pro Asn Val Asp Glu Gln Val Gln Ala Trp Glu Ser Arg Arg Pro
             530                 535                 540

 ctc att cag gac ctg gcc cag agg ctg ctg act gat gac gag gtg ctg     1739
 Leu Ile Gln Asp Leu Ala Gln Arg Leu Leu Thr Asp Asp Glu Val Leu
         545                 550                 555

 gct gtc acc cgc cac tgc tcc cgg tat gtg cac gag gga ggc ata gag     1787
 Ala Val Thr Arg His Cys Ser Arg Tyr Val His Glu Gly Gly Ile Glu
     560                 565                 570

 gac ctg gtg agg ccc ctg ctg gcc atc ctc gac agg ccg gag aag ctg     1835
 Asp Leu Val Arg Pro Leu Leu Ala Ile Leu Asp Arg Pro Glu Lys Leu
 575                 580                 585                 590

 cta ctg ctg cag gac atc agg agt gtg gtg gcc ccc aca gac ctg ggc     1883
 Leu Leu Leu Gln Asp Ile Arg Ser Val Val Ala Pro Thr Asp Leu Gly
                 595                 600                 605

 cgc ttc gac agc atg gtg atg ctt gtg gag ctg gag gct ttt gag gcc     1931
 Arg Phe Asp Ser Met Val Met Leu Val Glu Leu Glu Ala Phe Glu Ala
             610                 615                 620

 ctc aag agc agg gca gac agc cgc gga ggc ttc tac ctg ctg ccg gtg     1979
 Leu Lys Ser Arg Ala Asp Ser Arg Gly Gly Phe Tyr Leu Leu Pro Val
         625                 630                 635

 aac ggc ttc ccg gaa gag gaa gat aat ggg gag ctg agg gag cgg ctg     2027
 Asn Gly Phe Pro Glu Glu Glu Asp Asn Gly Glu Leu Arg Glu Arg Leu
     640                 645                 650

 ggg gcc ctc aag gtc tcc cca agt gcc tct gcc cct cgc cac ccc cat     2075
 Gly Ala Leu Lys Val Ser Pro Ser Ala Ser Ala Pro Arg His Pro His
 655                 660                 665                 670

 aaa ggg atc ccc cct cta caa gac gtg cca gta gat gcc ttc acc ccc     2123
 Lys Gly Ile Pro Pro Leu Gln Asp Val Pro Val Asp Ala Phe Thr Pro
                 675                 680                 685

 ctc cga att gcc tgc aca ccc cct ccc cag cta ccc ccc gtg gct ccc     2171
 Leu Arg Ile Ala Cys Thr Pro Pro Pro Gln Leu Pro Pro Val Ala Pro
             690                 695                 700

 cgg ccc ctg cgg cct aac tgg ctg ctg aca gaa ccc ctg agc cga gag     2219
 Arg Pro Leu Arg Pro Asn Trp Leu Leu Thr Glu Pro Leu Ser Arg Glu
         705                 710                 715

 cac cct ccg cag agc cag atc cgg ggc cgg gct cag agc cgt agc cgc     2267
 His Pro Pro Gln Ser Gln Ile Arg Gly Arg Ala Gln Ser Arg Ser Arg
     720                 725                 730

 agc cgt agc cgc agc cgc agc cgc agc agc cgg ggt caa ggc aag tct     2315
 Ser Arg Ser Arg Ser Arg Ser Arg Ser Ser Arg Gly Gln Gly Lys Ser
 735                 740                 745                 750

 cca ggt aga cgc tcc cca tcc ccg gtg cct acc cct gcc ccc agc atg     2363
 Pro Gly Arg Arg Ser Pro Ser Pro Val Pro Thr Pro Ala Pro Ser Met
                 755                 760                 765

 acc aat ggg cgc tac cac aag cct cgg aag gcc aga ccc cct ctg cca     2411
 Thr Asn Gly Arg Tyr His Lys Pro Arg Lys Ala Arg Pro Pro Leu Pro
             770                 775                 780

 cga cct ctg gat ggg gag gca gcc aag gtg ggg gcc aag caa ggg ccc     2459
 Arg Pro Leu Asp Gly Glu Ala Ala Lys Val Gly Ala Lys Gln Gly Pro
         785                 790                 795

 tcg gag agt gga act gag ggg acg gcc aag gag gca gcc atg aag aac     2507
 Ser Glu Ser Gly Thr Glu Gly Thr Ala Lys Glu Ala Ala Met Lys Asn
     800                 805                 810

 ccc agt ggc gag ctg aag aca gtg aca ctg tcc aag atg aag cag tcc     2555
 Pro Ser Gly Glu Leu Lys Thr Val Thr Leu Ser Lys Met Lys Gln Ser
 815                 820                 825                 830

 tta ggt atc agc att tct ggg ggc att gag tcc aag gtg cag ccc atg     2603
 Leu Gly Ile Ser Ile Ser Gly Gly Ile Glu Ser Lys Val Gln Pro Met
                 835                 840                 845

 gtg aag ata gag aag atc ttc cct ggg ggg gcc gct ttc ctc agt ggg     2651
 Val Lys Ile Glu Lys Ile Phe Pro Gly Gly Ala Ala Phe Leu Ser Gly
             850                 855                 860

 gcc ctg cag gct ggc ttc gag ctt gtg gca gtg gac gga gag aat cta     2699
 Ala Leu Gln Ala Gly Phe Glu Leu Val Ala Val Asp Gly Glu Asn Leu
         865                 870                 875

 gag cag gtg acc cac cag cgt gca gta gac acc atc cgt cgg gct tat     2747
 Glu Gln Val Thr His Gln Arg Ala Val Asp Thr Ile Arg Arg Ala Tyr
     880                 885                 890

 cga aac aag gcc cgg gag ccc atg gag ctt gtg act cct gat tct aag     2795
 Arg Asn Lys Ala Arg Glu Pro Met Glu Leu Val Thr Pro Asp Ser Lys
 895                 900                 905                 910

 ccc gca ccc tcc cca cgc atc cca tga                                 2822
 Pro Ala Pro Ser Pro Arg Ile Pro 
                 915





      <210> 404
      <211> 1934
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (28)..(1245)

      <400> 404
 ccctttgcca ggcagaaagg gtttccc    atg ggg ccg ccc ctg gcg ccg cgc      51
                                  Met Gly Pro Pro Leu Ala Pro Arg
                                    1               5

 ccg gcc cac gta ccc ggg gag gcc ggg ccc cgg agg acg agg gaa agc       99
 Pro Ala His Val Pro Gly Glu Ala Gly Pro Arg Arg Thr Arg Glu Ser
      10                  15                  20

 agg ccg ggc gcc gtg agc ttc gcg gac gtg gcc gtg tac ttc tct ccc      147
 Arg Pro Gly Ala Val Ser Phe Ala Asp Val Ala Val Tyr Phe Ser Pro
  25                  30                  35                  40

 gag gag tgg gaa tgc ctg cgg cca gcg cag agg gcc ctg tac cgg gac      195
 Glu Glu Trp Glu Cys Leu Arg Pro Ala Gln Arg Ala Leu Tyr Arg Asp
                  45                  50                  55

 gtg atg cgg gag acc ttc ggc cac ctg ggc gcg ctg gga ttt tca gtt      243
 Val Met Arg Glu Thr Phe Gly His Leu Gly Ala Leu Gly Phe Ser Val
              60                  65                  70

 ccc aaa ccc gct ttt atc tcg tgg gtg gaa gga gaa gtg gag gcg tgg      291
 Pro Lys Pro Ala Phe Ile Ser Trp Val Glu Gly Glu Val Glu Ala Trp
          75                  80                  85

 agc ccg gag gcc cag gat ccc gac ggt gag agc tct gca gct ttc agc      339
 Ser Pro Glu Ala Gln Asp Pro Asp Gly Glu Ser Ser Ala Ala Phe Ser
      90                  95                 100

 agg ggc caa gga cag gaa gca gga tcc agg gat ggg aat gag gag aag      387
 Arg Gly Gln Gly Gln Glu Ala Gly Ser Arg Asp Gly Asn Glu Glu Lys
 105                 110                 115                 120

 gaa agg ctg aag aag tgt cca aaa caa aaa gag gtg gcg cat gaa gtg      435
 Glu Arg Leu Lys Lys Cys Pro Lys Gln Lys Glu Val Ala His Glu Val
                 125                 130                 135

 gct gtc aag gag tgg tgg ccc agc gtc gcc tgc cca gag ttc tgc aac      483
 Ala Val Lys Glu Trp Trp Pro Ser Val Ala Cys Pro Glu Phe Cys Asn
             140                 145                 150

 cct agg cag agc ccc atg aat ccc tgg ctc aag gac act ctg acc cga      531
 Pro Arg Gln Ser Pro Met Asn Pro Trp Leu Lys Asp Thr Leu Thr Arg
         155                 160                 165

 aga ctg ccc cac tct tgc cca gac tgt ggc cgc aac ttc agc tac cct      579
 Arg Leu Pro His Ser Cys Pro Asp Cys Gly Arg Asn Phe Ser Tyr Pro
     170                 175                 180

 tcc ctc ctg gcc agc cac cag cgg gtc cac tcc ggg gag cgg ccc ttc      627
 Ser Leu Leu Ala Ser His Gln Arg Val His Ser Gly Glu Arg Pro Phe
 185                 190                 195                 200

 tcc tgc ggc cag tgt cag gcg cgt ttc tcc cag cgc agg tac ctg ctc      675
 Ser Cys Gly Gln Cys Gln Ala Arg Phe Ser Gln Arg Arg Tyr Leu Leu
                 205                 210                 215

 cag cat cag ttc atc cac acc ggc gag aag ccc tac ccc tgc ccc gac      723
 Gln His Gln Phe Ile His Thr Gly Glu Lys Pro Tyr Pro Cys Pro Asp
             220                 225                 230

 tgc ggg cgc cgc ttc cgc cag agg ggt tcc ctg gct atc cac agg cgg      771
 Cys Gly Arg Arg Phe Arg Gln Arg Gly Ser Leu Ala Ile His Arg Arg
         235                 240                 245

 gct cac acc ggg gag aag cct tac gcg tgc tca gac tgc aag agt cgc      819
 Ala His Thr Gly Glu Lys Pro Tyr Ala Cys Ser Asp Cys Lys Ser Arg
     250                 255                 260

 ttc act tac ccc tac ctg ctg gcc atc cac cag cgc aag cac acg ggc      867
 Phe Thr Tyr Pro Tyr Leu Leu Ala Ile His Gln Arg Lys His Thr Gly
 265                 270                 275                 280

 gag aag ccc tac agc tgc ccc gat tgc agc ctc cgt ttc gcc tac acc      915
 Glu Lys Pro Tyr Ser Cys Pro Asp Cys Ser Leu Arg Phe Ala Tyr Thr
                 285                 290                 295

 tcc ctg ctg gcc atc cac agg cgc ata cac acc ggc gag aag ccc tac      963
 Ser Leu Leu Ala Ile His Arg Arg Ile His Thr Gly Glu Lys Pro Tyr
             300                 305                 310

 ccc tgt cct gac tgc ggc cgc cgc ttc acc tat tct tcc ctc ctc ctc     1011
 Pro Cys Pro Asp Cys Gly Arg Arg Phe Thr Tyr Ser Ser Leu Leu Leu
         315                 320                 325

 agt cac cgg cgc att cac tcc gac agc cgg ccc ttc ccc tgc gtg gag     1059
 Ser His Arg Arg Ile His Ser Asp Ser Arg Pro Phe Pro Cys Val Glu
     330                 335                 340

 tgt ggg aaa ggc ttc aag cgc aag acc gcc ctg gaa gcc cat cgg tgg     1107
 Cys Gly Lys Gly Phe Lys Arg Lys Thr Ala Leu Glu Ala His Arg Trp
 345                 350                 355                 360

 atc cac cgc tcc tgc agc gag agg cgc gcg tgg cag cag gcc gtg gtg     1155
 Ile His Arg Ser Cys Ser Glu Arg Arg Ala Trp Gln Gln Ala Val Val
                 365                 370                 375

 ggg cgt tca gag ccc atc cct gtt ttg gga ggc aag gat ccc cca gtt     1203
 Gly Arg Ser Glu Pro Ile Pro Val Leu Gly Gly Lys Asp Pro Pro Val
             380                 385                 390

 cac ttc cgg cac ttt cca gat ata ttt caa gag tgt ggg tga tggcgtt     1252
 His Phe Arg His Phe Pro Asp Ile Phe Gln Glu Cys Gly 
         395                 400                 405

 cacacaaact ggtcagcgtt tccctgcttc taccgcgggt gtacacatgg tttgccaggg   1312

 tgtgcgcgtc ttcccaaggg gtctggggac caaattccag ctcccgccat cgggaggcac   1372

 ggtaagagac cgtaggggac acaatcccga gcaccgcaga tgccgaggtc tccgctgcgc   1432

 tccagtctgt caacagaggc ttcaggaccg cggggtccct tcaaatgccc cgccagtcac   1492

 agaccaatcg ccgcgcagct tcttccggga tcgtcgccaa tcatcggccg ttgcgtattg   1552

 cgggtacaga ggggattccc aggccccaaa ccagccctca tctcttggat ggaacaggag   1612

 agtgaggctt ggagccccgc cgcccaggat cctgagaagg gggaaagact gggaggagct   1672

 cggagaggag atgtcccaaa caggaaggaa gaggaaccgg aggaagtccc aagagccaaa   1732

 gggcctagaa aggctcctgt gaaggagagt cctgaagtgc tggtggaacg caaccctgac   1792

 ccagctatta gcgtggcccc ggcacgggca cagccaccca aaaatgctgc ctgggacccg   1852

 accacaggag cacagccccc ggcacccata cccagcatgg atgctcaggc cggccagcgg   1912

 cgccacgtgt gcacggactc gg                                            1934




      <210> 405
      <211> 1068
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (100)..(1068)

      <400> 405
 tttcgtcgcg tcatgccagg cgctgctcgg cggtagggag tgcccggtgc cgccgtctcc     60

 gcccgcccga agccgcgccc actgcccaga gccagaggg   atg gtg gta gtc acg     114
                                              Met Val Val Val Thr
                                                1               5

 ggg cgg gag cca gac agc cgt cgt cag gac ggt gcc atg tcc agc tct      162
 Gly Arg Glu Pro Asp Ser Arg Arg Gln Asp Gly Ala Met Ser Ser Ser
                  10                  15                  20

 gac gcc gaa gac gac ttt ctg gag ccg gcc acg ccg acg gcc acg cag      210
 Asp Ala Glu Asp Asp Phe Leu Glu Pro Ala Thr Pro Thr Ala Thr Gln
              25                  30                  35

 gcg ggg cac gcg ctg ccc ctg ctg cca cag gag ttt cct gag gtt gtt      258
 Ala Gly His Ala Leu Pro Leu Leu Pro Gln Glu Phe Pro Glu Val Val
          40                  45                  50

 ccc ctt aac atc gga ggg gct cac ttc act aca cgc ctg tcc aca ctg      306
 Pro Leu Asn Ile Gly Gly Ala His Phe Thr Thr Arg Leu Ser Thr Leu
      55                  60                  65

 cgg tgc tac gaa gac acc atg ttg gca gcc atg ttc agt ggg cgg cac      354
 Arg Cys Tyr Glu Asp Thr Met Leu Ala Ala Met Phe Ser Gly Arg His
  70                  75                  80                  85

 tac atc ccc acg gac tcc gag ggc cgg tac ttc atc gac cga gat ggc      402
 Tyr Ile Pro Thr Asp Ser Glu Gly Arg Tyr Phe Ile Asp Arg Asp Gly
                  90                  95                 100

 aca cac ttt gga gat gtg ctg aat ttc ctg cgc tca ggg gac ctc cca      450
 Thr His Phe Gly Asp Val Leu Asn Phe Leu Arg Ser Gly Asp Leu Pro
             105                 110                 115

 ccc agg gag cgt gtt cga gct gtg tac aaa gag gcc cag tac tat gcc      498
 Pro Arg Glu Arg Val Arg Ala Val Tyr Lys Glu Ala Gln Tyr Tyr Ala
         120                 125                 130

 atc ggg ccc ctc ctg gag cag ctg gag aac atg cag cca ctg aag ggc      546
 Ile Gly Pro Leu Leu Glu Gln Leu Glu Asn Met Gln Pro Leu Lys Gly
     135                 140                 145

 gag aag gtg cgc caa gcg ttt ctg gga ctc atg ccc tat tac aaa gac      594
 Glu Lys Val Arg Gln Ala Phe Leu Gly Leu Met Pro Tyr Tyr Lys Asp
 150                 155                 160                 165

 cac ttg gag cgg att gtg gag atc gcc cgg ctg cgt gcg gtc cag cgg      642
 His Leu Glu Arg Ile Val Glu Ile Ala Arg Leu Arg Ala Val Gln Arg
                 170                 175                 180

 aag gcc cgc ttt gcc aag ctc aag gtc tgt gtc ttc aag gag gag atg      690
 Lys Ala Arg Phe Ala Lys Leu Lys Val Cys Val Phe Lys Glu Glu Met
             185                 190                 195

 ccc atc acc ccc tat gag tgt ccg ctc ctc aac tcc ctg cga ttt gag      738
 Pro Ile Thr Pro Tyr Glu Cys Pro Leu Leu Asn Ser Leu Arg Phe Glu
         200                 205                 210

 cgg agt gag agt gac ggg cag ctt ttt gag cac cac tgt gaa gtg gat      786
 Arg Ser Glu Ser Asp Gly Gln Leu Phe Glu His His Cys Glu Val Asp
     215                 220                 225

 gtg tct ttt ggg ccc tgg gag gct gtg gct gat gtt tat gac ctg ctg      834
 Val Ser Phe Gly Pro Trp Glu Ala Val Ala Asp Val Tyr Asp Leu Leu
 230                 235                 240                 245

 cac tgc ctg gtc acg gac ctc tcg gcc cag ggt ctc acc gtg gac cac      882
 His Cys Leu Val Thr Asp Leu Ser Ala Gln Gly Leu Thr Val Asp His
                 250                 255                 260

 cag tgc atc ggg gtg tgt gac aag cac ctc gtg aac cac tac tac tgc      930
 Gln Cys Ile Gly Val Cys Asp Lys His Leu Val Asn His Tyr Tyr Cys
             265                 270                 275

 aag cgc ccc atc tat gag ttc aag atc aca tgg tgg cgg ctg tat ttg      978
 Lys Arg Pro Ile Tyr Glu Phe Lys Ile Thr Trp Trp Arg Leu Tyr Leu
         280                 285                 290

 gaa act ccc att ggt cca gag aga cag aac aat gag aag aaa tcc cct     1026
 Glu Thr Pro Ile Gly Pro Glu Arg Gln Asn Asn Glu Lys Lys Ser Pro
     295                 300                 305

 gtc cag ttg cct gca gga gta ttc caa cac ttc atg ggc tag             1068
 Val Gln Leu Pro Ala Gly Val Phe Gln His Phe Met Gly 
 310                 315                 320





      <210> 406
      <211> 3168
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (985)..(3168)

      <400> 406
 atggccttga gaaaacgaaa gcacacgcag gcactgcgcc gcacaagccc agtagggcgc     60

 gggaacccga tggaatgcgg aacgtcgctg ctcggcagct ccctacggct ggcggctgcg    120

 acccgcgtgg gccgcgagtt gtggcggcgg gttccggggc ccccccacag catccgtcct    180

 cttgtcccac cgcccgtcgg acagtcggtc ggtctttcgt ggccccgcgc gcccgctgcc    240

 cggctcgtgc gtttcctttg cttgctgcct ccggctccgc tccccgcagc ccagcgggtt    300

 gttatcatta ttcaggccca agttcacggg cactgcatcc atttccctcg cgtggcccgg    360

 ggccaactca ggccgcaggt tgcgatgctc gagcccttgg acccggcctc tccgcctacg    420

 tcggccatca gagcctcgct cgctgcccga gagcctcgca ttgacgccgg cccgcgcgtg    480

 agtcaagcct gcgtcacggc gccccgccgc cagggtggcc tttcggaaag cgagggaaca    540

 gtgcgcgcag cgctccgccc agctccgttc tgctccgcag agccggcgct gccaggggca    600

 gggagggcgg cactcggccc cagtcttcgc aatcccgcgc gctctctccg ccgtgggacc    660

 tgggttccgc gccgctcccc tgagcccgag cgcgcgcggc gggacagagt tgggactggt    720

 ggtgaggcag ggagtgagga gcgagcggag tcgcgtgtcc ggctccagct ccgagtcgcc    780

 ccagccccag ccgtgcgctg tgcgtggggg aggagctgtg cgtccgtacc cgtcaggacc    840

 gcagctgctc ggccggagtg cacgggccga gtctgcgcga ctacccacgc gtgacaggtc    900

 cctgaatgag aaggagctga cagcagctga attccatctt ctctgtgtgc tggggagcag    960

 ggctacacgg cccaggtggc atca   atg ccg aag aac agc aaa gtg acc cag    1011
                              Met Pro Lys Asn Ser Lys Val Thr Gln
                                1               5

 cgt gag cac agc agt gag cat gtc act gag tcc gtg gcc gac ctg ctg     1059
 Arg Glu His Ser Ser Glu His Val Thr Glu Ser Val Ala Asp Leu Leu
  10                  15                  20                  25

 gcc ctc gag gag cct gtg gac tat aag cag agt gta ctg aat gtg gct     1107
 Ala Leu Glu Glu Pro Val Asp Tyr Lys Gln Ser Val Leu Asn Val Ala
                  30                  35                  40

 ggt gag gca ggc ggc aag cag aag gcg gtg gag gag gag ctg gac aca     1155
 Gly Glu Ala Gly Gly Lys Gln Lys Ala Val Glu Glu Glu Leu Asp Thr
              45                  50                  55

 gag gac cgg ccg gcc tgg aac agt aag ctg cag tac atc ctg gcc cag     1203
 Glu Asp Arg Pro Ala Trp Asn Ser Lys Leu Gln Tyr Ile Leu Ala Gln
          60                  65                  70

 att ggc ttc tct gtg ggc ctc ggc aac atc tgg agg ttc ccc tac ctg     1251
 Ile Gly Phe Ser Val Gly Leu Gly Asn Ile Trp Arg Phe Pro Tyr Leu
      75                  80                  85

 tgc cag aaa aat gga gga ggt gct tac ctg gtg ccc tac ctg gtg ctg     1299
 Cys Gln Lys Asn Gly Gly Gly Ala Tyr Leu Val Pro Tyr Leu Val Leu
  90                  95                 100                 105

 ctg atc atc atc ggg atc ccc ctc ttc ttc ctg gag ctg gct gtg ggt     1347
 Leu Ile Ile Ile Gly Ile Pro Leu Phe Phe Leu Glu Leu Ala Val Gly
                 110                 115                 120

 cag agg atc cgc cgc ggc agc atc ggt gtg tgg cac tat ata tgt ccc     1395
 Gln Arg Ile Arg Arg Gly Ser Ile Gly Val Trp His Tyr Ile Cys Pro
             125                 130                 135

 cgc ctg ggg ggc atc ggc ttc tcc agc tgc ata gtc tgt ctc ttt gtg     1443
 Arg Leu Gly Gly Ile Gly Phe Ser Ser Cys Ile Val Cys Leu Phe Val
         140                 145                 150

 ggg ctg tat tat aat gtg atc atc ggg tgg agc atc ttc tat ttc ttc     1491
 Gly Leu Tyr Tyr Asn Val Ile Ile Gly Trp Ser Ile Phe Tyr Phe Phe
     155                 160                 165

 aag tcc ttc cag tac ccg ctg ccc tgg agt gaa tgt cct gtc gtc agg     1539
 Lys Ser Phe Gln Tyr Pro Leu Pro Trp Ser Glu Cys Pro Val Val Arg
 170                 175                 180                 185

 aat ggg agc gtg gca gtg gtg gag gca gag tgt gaa aag agc tca gcc     1587
 Asn Gly Ser Val Ala Val Val Glu Ala Glu Cys Glu Lys Ser Ser Ala
                 190                 195                 200

 act acc tac ttc tgg tac cga gag gcc ttg gac atc tct gac tcc atc     1635
 Thr Thr Tyr Phe Trp Tyr Arg Glu Ala Leu Asp Ile Ser Asp Ser Ile
             205                 210                 215

 tcg gag agt ggg ggc ctc aac tgg aag atg acc ctg tgc ctc ctc gtg     1683
 Ser Glu Ser Gly Gly Leu Asn Trp Lys Met Thr Leu Cys Leu Leu Val
         220                 225                 230

 gcc tgg agc atc gtg ggg atg gct gtc gtt aag ggc atc cag tcc tcg     1731
 Ala Trp Ser Ile Val Gly Met Ala Val Val Lys Gly Ile Gln Ser Ser
     235                 240                 245

 ggg aag gtg atg tat ttc agc tcc ctc ttc ccc tac gtg gtg ctg gcc     1779
 Gly Lys Val Met Tyr Phe Ser Ser Leu Phe Pro Tyr Val Val Leu Ala
 250                 255                 260                 265

 tgc ttc ctg gtc cgg ggg ctg ttg ctg cga ggg gca gtt gat ggc atc     1827
 Cys Phe Leu Val Arg Gly Leu Leu Leu Arg Gly Ala Val Asp Gly Ile
                 270                 275                 280

 cta cac atg ttc act ccc aag ctg gac aag atg ctg gac ccc cag gtg     1875
 Leu His Met Phe Thr Pro Lys Leu Asp Lys Met Leu Asp Pro Gln Val
             285                 290                 295

 tgg cgg gag gca gct acc cag gtc ttc tct gcc ttg ggc ctg ggc ttt     1923
 Trp Arg Glu Ala Ala Thr Gln Val Phe Ser Ala Leu Gly Leu Gly Phe
         300                 305                 310

 ggt ggt gtc att gcc ttc tcc agc tac aat aag cag gac aac aac tgc     1971
 Gly Gly Val Ile Ala Phe Ser Ser Tyr Asn Lys Gln Asp Asn Asn Cys
     315                 320                 325

 cac ttc gat gcc gcc ctg gtg tcc ttc atc aac ttc ttc acg tca gtg     2019
 His Phe Asp Ala Ala Leu Val Ser Phe Ile Asn Phe Phe Thr Ser Val
 330                 335                 340                 345

 ttg gcc acc ctc gtg gtg ttt gct gtg ctg ggc ttc aag gcc aac atc     2067
 Leu Ala Thr Leu Val Val Phe Ala Val Leu Gly Phe Lys Ala Asn Ile
                 350                 355                 360

 atg aat gag aag tgt gtg gtc gag aat gct gag aaa atc cta ggg tac     2115
 Met Asn Glu Lys Cys Val Val Glu Asn Ala Glu Lys Ile Leu Gly Tyr
             365                 370                 375

 ctt aac acc aac gtc ctg agc cgg gac ctc atc cca ccc cac gtc aac     2163
 Leu Asn Thr Asn Val Leu Ser Arg Asp Leu Ile Pro Pro His Val Asn
         380                 385                 390

 ttc tcc cac ctg acc aca aag gac tac atg gag atg tac aat gtc atc     2211
 Phe Ser His Leu Thr Thr Lys Asp Tyr Met Glu Met Tyr Asn Val Ile
     395                 400                 405

 atg acc gtg aag gag gac cag ttc tca gcc ctg ggc ctt gac ccc tgc     2259
 Met Thr Val Lys Glu Asp Gln Phe Ser Ala Leu Gly Leu Asp Pro Cys
 410                 415                 420                 425

 ctt ctg gag gac gag ctg gac aag tcc gtg cag ggc aca ggc ctg gcc     2307
 Leu Leu Glu Asp Glu Leu Asp Lys Ser Val Gln Gly Thr Gly Leu Ala
                 430                 435                 440

 ttc atc gcc ttc act gag gcc atg acg cac ttc ccc gcc tcc ccg ttc     2355
 Phe Ile Ala Phe Thr Glu Ala Met Thr His Phe Pro Ala Ser Pro Phe
             445                 450                 455

 tgg tcc gtc atg ttc ttc ttg atg ctt atc aac ctg ggc ctg ggc agc     2403
 Trp Ser Val Met Phe Phe Leu Met Leu Ile Asn Leu Gly Leu Gly Ser
         460                 465                 470

 atg atc ggg acc atg gca ggc atc acc acg ccc atc atc gac acc ttc     2451
 Met Ile Gly Thr Met Ala Gly Ile Thr Thr Pro Ile Ile Asp Thr Phe
     475                 480                 485

 aag gtg ccc aag gag atg ttc aca gtg ggc tgc tgt gtc ttt gca ttc     2499
 Lys Val Pro Lys Glu Met Phe Thr Val Gly Cys Cys Val Phe Ala Phe
 490                 495                 500                 505

 ctc gtg ggg ctg ttg ttc gtc cag cgc tcc gga aac tac ttt gtc acc     2547
 Leu Val Gly Leu Leu Phe Val Gln Arg Ser Gly Asn Tyr Phe Val Thr
                 510                 515                 520

 atg ttc gat gac tac tcg gcc acc ctg cca ctc act ctc atc gtc atc     2595
 Met Phe Asp Asp Tyr Ser Ala Thr Leu Pro Leu Thr Leu Ile Val Ile
             525                 530                 535

 ctt gag aac atc gct gtg gcc tgg att tat gga acc aag aag ttc atg     2643
 Leu Glu Asn Ile Ala Val Ala Trp Ile Tyr Gly Thr Lys Lys Phe Met
         540                 545                 550

 cag gag ctg acg gag atg ctg ggc ttc cgc ccc tac cgc ttc tat ttc     2691
 Gln Glu Leu Thr Glu Met Leu Gly Phe Arg Pro Tyr Arg Phe Tyr Phe
     555                 560                 565

 tac atg tgg aag ttc gtg tct cca cta tgc atg gct gtg ctc acc aca     2739
 Tyr Met Trp Lys Phe Val Ser Pro Leu Cys Met Ala Val Leu Thr Thr
 570                 575                 580                 585

 gcc agc atc atc cag ctg ggg gtc acg ccc ccg ggc tac agc gcc tgg     2787
 Ala Ser Ile Ile Gln Leu Gly Val Thr Pro Pro Gly Tyr Ser Ala Trp
                 590                 595                 600

 atc aag gag gag gct gcc gag cgc tac ctg tat ttc ccc aac tgg gcc     2835
 Ile Lys Glu Glu Ala Ala Glu Arg Tyr Leu Tyr Phe Pro Asn Trp Ala
             605                 610                 615

 atg gca ctc ctg atc acc ctc atc gtc gtg gcg acg ctg ccc atc cct     2883
 Met Ala Leu Leu Ile Thr Leu Ile Val Val Ala Thr Leu Pro Ile Pro
         620                 625                 630

 gtg gtg ttc gtc ctg cgg cac ttc cac ctg ctc tct gat ggc tcc aac     2931
 Val Val Phe Val Leu Arg His Phe His Leu Leu Ser Asp Gly Ser Asn
     635                 640                 645

 acc ctc tcc gtg tcc tac aag aag ggc cgc atg atg aag gac atc tcc     2979
 Thr Leu Ser Val Ser Tyr Lys Lys Gly Arg Met Met Lys Asp Ile Ser
 650                 655                 660                 665

 aac ctg gag gag aac gat gag acc cgc ttc atc ctc agc aag gtg ccc     3027
 Asn Leu Glu Glu Asn Asp Glu Thr Arg Phe Ile Leu Ser Lys Val Pro
                 670                 675                 680

 agt gag gca cct tcc ccc atg ccc act cac cgt tcc tat ctg ggg ccc     3075
 Ser Glu Ala Pro Ser Pro Met Pro Thr His Arg Ser Tyr Leu Gly Pro
             685                 690                 695

 ggc agc aca tca ccc ctg gag acc agc ggt aac ccc aat gga cgc tat     3123
 Gly Ser Thr Ser Pro Leu Glu Thr Ser Gly Asn Pro Asn Gly Arg Tyr
         700                 705                 710

 ggg agc ggc tac ctg ctg gcc agc acc cct gag tcg gag ctg tga         3168
 Gly Ser Gly Tyr Leu Leu Ala Ser Thr Pro Glu Ser Glu Leu 
     715                 720                 725





      <210> 407
      <211> 913
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (23)..(475)

      <400> 407
 tcgatcatct tcgctagcag gg atg gac atg atg ctg ttg gtg cag ggt gct      52
                          Met Asp Met Met Leu Leu Val Gln Gly Ala
                            1               5                  10

 tgt tgc tcg aac cag tgg ctg gcg gcg gtg ctc ctc agc ctg tgc tgc      100
 Cys Cys Ser Asn Gln Trp Leu Ala Ala Val Leu Leu Ser Leu Cys Cys
                  15                  20                  25

 ctg cta ccc tcc tgc ctc ccg gct gga cag agt gtg gac ttc ccc tgg      148
 Leu Leu Pro Ser Cys Leu Pro Ala Gly Gln Ser Val Asp Phe Pro Trp
              30                  35                  40

 gcg gcc gtg gac aac atg atg gtc aga aaa ggg gac acg gcg gtg ctt      196
 Ala Ala Val Asp Asn Met Met Val Arg Lys Gly Asp Thr Ala Val Leu
          45                  50                  55

 agg tgt tat ttg gaa gat gga gct tca aag ggt gcc tgg ctg aac cgg      244
 Arg Cys Tyr Leu Glu Asp Gly Ala Ser Lys Gly Ala Trp Leu Asn Arg
      60                  65                  70

 tca agt att att ttt gcg gga ggt gat aag tgg tca gtg gat cct cga      292
 Ser Ser Ile Ile Phe Ala Gly Gly Asp Lys Trp Ser Val Asp Pro Arg
  75                  80                  85                  90

 gtt tca att tca aca ttg aat aaa agg gac tac agc ctc cag ata cag      340
 Val Ser Ile Ser Thr Leu Asn Lys Arg Asp Tyr Ser Leu Gln Ile Gln
                  95                 100                 105

 aat gta gat gtg aca gat gat ggc cca tac acg tgt tct gtt cag act      388
 Asn Val Asp Val Thr Asp Asp Gly Pro Tyr Thr Cys Ser Val Gln Thr
             110                 115                 120

 caa cat aca ccc aga aca atg cag gtg cat cta act gtg caa ggt atg      436
 Gln His Thr Pro Arg Thr Met Gln Val His Leu Thr Val Gln Gly Met
         125                 130                 135

 tat ttt cag aac tgc tat att gtg aaa gac tgt gct tag aaatatttaa       485
 Tyr Phe Gln Asn Cys Tyr Ile Val Lys Asp Cys Ala 
     140                 145                 150

 tatttaggta tcaaaatgac taggaagcag ttaacaatgt tgaaatattt gctgtcattg    545

 aaatatttgt tgaattatat tgtcatagtt ttcaggaatt tacattccta gacatcagaa    605

 agtcattaag agtcatacag acagaatgaa aaagtctttt gactggcttt cagttgaaac    665

 acacacgcgc acacacatac gcgtctttat taaaaggtat gcaagtattg tagtcattaa    725

 gaagtgtaat gactattaca ggcatacaaa tccctactta caaagataaa gaaatatcca    785

 ttaacaccat attatgacat ttgtaactga ttcacctcat atcttgcttt gattcatccc    845

 ttcataaatc tgtgggggcc catgatgaca cttagatgtt tgaaccttca atagatactg    905

 gaattttt                                                             913




      <210> 408
      <211> 1195
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (67)..(1017)

      <400> 408
 cggacgcgtg ggcagccttg ctagagtctg aggactatcc agggcctgac tgccagctag     60

 ccagcc   atg ggc cag gat tat tac tct gtg ctc ggg atc act cgc aat     108
          Met Gly Gln Asp Tyr Tyr Ser Val Leu Gly Ile Thr Arg Asn
            1               5                  10

 tca gag gat gcc cag atc aag cag gcg tac cgc aga ctc gcc ctt aag      156
 Ser Glu Asp Ala Gln Ile Lys Gln Ala Tyr Arg Arg Leu Ala Leu Lys
  15                  20                  25                  30

 cac cac ccg ttg aag tca aat gag ccg tct tca gca gag att ttc agg      204
 His His Pro Leu Lys Ser Asn Glu Pro Ser Ser Ala Glu Ile Phe Arg
                  35                  40                  45

 caa ata gca gag gcc tac gac gtg ctg agt gac ccc atg aag aga ggc      252
 Gln Ile Ala Glu Ala Tyr Asp Val Leu Ser Asp Pro Met Lys Arg Gly
              50                  55                  60

 atc tac gac aag ttt gga gaa gag ggc ctg aag ggt ggg att cct ttg      300
 Ile Tyr Asp Lys Phe Gly Glu Glu Gly Leu Lys Gly Gly Ile Pro Leu
          65                  70                  75

 gag ttt gga tcc cag acc cca tgg aca act ggt tac gtc ttc cac ggc      348
 Glu Phe Gly Ser Gln Thr Pro Trp Thr Thr Gly Tyr Val Phe His Gly
      80                  85                  90

 aaa cct gaa aag gtg ttc cac gag ttc ttt ggt gga aac aac ccc ttc      396
 Lys Pro Glu Lys Val Phe His Glu Phe Phe Gly Gly Asn Asn Pro Phe
  95                 100                 105                 110

 agt gag ttt ttt gat gca gaa gga agt gag gta gat ttg aac ttt ggg      444
 Ser Glu Phe Phe Asp Ala Glu Gly Ser Glu Val Asp Leu Asn Phe Gly
                 115                 120                 125

 agg ctc cag ggc cga ggg gtc aag aag cag gac ccc caa gtc gaa cgg      492
 Arg Leu Gln Gly Arg Gly Val Lys Lys Gln Asp Pro Gln Val Glu Arg
             130                 135                 140

 gat ctc tac ctg tcc ctg gag gac tta ttc ttt ggc tgc acc aaa aaa      540
 Asp Leu Tyr Leu Ser Leu Glu Asp Leu Phe Phe Gly Cys Thr Lys Lys
         145                 150                 155

 att aag atc tcc aga agg gtg ctg aac gag gat ggg tac tcc tcc acc      588
 Ile Lys Ile Ser Arg Arg Val Leu Asn Glu Asp Gly Tyr Ser Ser Thr
     160                 165                 170

 atc aag gac aag atc ctg acc att gat gtg aag ccc ggt tgg agg cag      636
 Ile Lys Asp Lys Ile Leu Thr Ile Asp Val Lys Pro Gly Trp Arg Gln
 175                 180                 185                 190

 ggc aca cgc atc acc ttt gag aag gaa ggg gac cag ggc ccc aac atc      684
 Gly Thr Arg Ile Thr Phe Glu Lys Glu Gly Asp Gln Gly Pro Asn Ile
                 195                 200                 205

 atc cca gca gac atc att ttc atc gta aag gag aag cta cac cct cgc      732
 Ile Pro Ala Asp Ile Ile Phe Ile Val Lys Glu Lys Leu His Pro Arg
             210                 215                 220

 ttc cgc agg gag aat gac aac ctc ttc ttc gtg aac ccc atc cct ctt      780
 Phe Arg Arg Glu Asn Asp Asn Leu Phe Phe Val Asn Pro Ile Pro Leu
         225                 230                 235

 ggc aag gct ctc acc tgc tgc act gtg gag gtg agg acc cta gat gac      828
 Gly Lys Ala Leu Thr Cys Cys Thr Val Glu Val Arg Thr Leu Asp Asp
     240                 245                 250

 cgt ctg ctc aac atc ccc atc aat gac atc atc cac ccc aaa tac ttc      876
 Arg Leu Leu Asn Ile Pro Ile Asn Asp Ile Ile His Pro Lys Tyr Phe
 255                 260                 265                 270

 aag aag gtg cca ggg gag ggg atg cca ttg ccg gag gac ccc act aag      924
 Lys Lys Val Pro Gly Glu Gly Met Pro Leu Pro Glu Asp Pro Thr Lys
                 275                 280                 285

 aaa ggg gat ctc ttc atc ttc ttc gac atc cag ttc ccc acc cgc ctc      972
 Lys Gly Asp Leu Phe Ile Phe Phe Asp Ile Gln Phe Pro Thr Arg Leu
             290                 295                 300

 aca ccc cag aag aag cag atg ctg cgc cag gca ttg ctg aca tga ctg     1020
 Thr Pro Gln Lys Lys Gln Met Leu Arg Gln Ala Leu Leu Thr 
         305                 310                 315

 tggtgggctg gagcaggggt gaaaggaggc tagccgggcc tcaccccacc cctacccgcc   1080

 acagcctcag ggtgtgcagg ggagcctgct gcacagatat gatacaaggg tgggatggcg   1140

 cagggcttaa actgacataa taaagatcta tttcctgtcc tccaaaaaaa aaaaa        1195




      <210> 409
      <211> 1883
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (355)..(1269)

      <400> 409
 atgcagaacc agatcagcca ccgctgccgg gcggactcac cgtctgcaga ccctcaggcc     60

 ctgggagttt ctcggcccga cctttgccct ccgtcctgtt cctgtttgct gcagcagcca    120

 ggggaggagc agccaccagc tcaagcccca gggcacgtct gcaccgccgc ccaccatctg    180

 cagcccaccc cggggcagga cgctcctgcc tccacagccc cggggacatg gcctcggtcc    240

 cctgcaaacc ccagccccgt agccctgcga ggttacagac agcctaaacg ccaccaccac    300

 agggcctgtg ccgtgcccct gacccgggca cagaaggcca ctggcccgga ggcc  atg     357
                                                              Met
                                                                1

 gag acg gtg ccc cca gca gtg gac ctg gtg ctg ggt gct tct gcc tgc      405
 Glu Thr Val Pro Pro Ala Val Asp Leu Val Leu Gly Ala Ser Ala Cys
               5                  10                  15

 tgc ctg gcc tgt gtc ttc acc aac ccc ctg gag gtg gtg aag acg cgg      453
 Cys Leu Ala Cys Val Phe Thr Asn Pro Leu Glu Val Val Lys Thr Arg
          20                  25                  30

 ctg cag ctg cag ggg gag ctg cag gcc cgg ggc acc tac cca cgg ccc      501
 Leu Gln Leu Gln Gly Glu Leu Gln Ala Arg Gly Thr Tyr Pro Arg Pro
      35                  40                  45

 tac cat ggc ttc ata gcc tct gtc gct gct gtg gcc cga gca gac ggg      549
 Tyr His Gly Phe Ile Ala Ser Val Ala Ala Val Ala Arg Ala Asp Gly
  50                  55                  60                  65

 ctg tgg ggc ctg cag aag ggg ctg gct gcc ggc ctt ctg tac caa ggc      597
 Leu Trp Gly Leu Gln Lys Gly Leu Ala Ala Gly Leu Leu Tyr Gln Gly
                  70                  75                  80

 ctc atg aat ggc gtt cgt ttc tac tgc tac agc ctg gcg tgc cag gct      645
 Leu Met Asn Gly Val Arg Phe Tyr Cys Tyr Ser Leu Ala Cys Gln Ala
              85                  90                  95

 ggc ctc acg cag caa cca ggt ggc acc gtg gtt gcg gga gcc gtg gcg      693
 Gly Leu Thr Gln Gln Pro Gly Gly Thr Val Val Ala Gly Ala Val Ala
         100                 105                 110

 ggg gca ctg gga gcc ttc gtg ggg agc cct gct tac ctg atc aaa acg      741
 Gly Ala Leu Gly Ala Phe Val Gly Ser Pro Ala Tyr Leu Ile Lys Thr
     115                 120                 125

 cag ctg caa gct cag aca gtg gcc gca gtg gcc gtg gga cac cag cac      789
 Gln Leu Gln Ala Gln Thr Val Ala Ala Val Ala Val Gly His Gln His
 130                 135                 140                 145

 aat cac cag act gtc ctg ggt gcc ttg gag acc atc tgg cgg cag caa      837
 Asn His Gln Thr Val Leu Gly Ala Leu Glu Thr Ile Trp Arg Gln Gln
                 150                 155                 160

 ggg ctc ttg ggg ctg tgg cag ggc gtt ggt ggg gct gtg ccc cga gtc      885
 Gly Leu Leu Gly Leu Trp Gln Gly Val Gly Gly Ala Val Pro Arg Val
             165                 170                 175

 atg gtg ggc tca gct gcc cag ctg gcc acc ttc gcc tct gcc aag gcc      933
 Met Val Gly Ser Ala Ala Gln Leu Ala Thr Phe Ala Ser Ala Lys Ala
         180                 185                 190

 tgg gta cag aag caa cag tgg ctc cct gag gac agc tgg ctg gtg gcc      981
 Trp Val Gln Lys Gln Gln Trp Leu Pro Glu Asp Ser Trp Leu Val Ala
     195                 200                 205

 ctg gct ggg ggc atg atc agc agc ata gcc gtg gtt gtc gtc atg act     1029
 Leu Ala Gly Gly Met Ile Ser Ser Ile Ala Val Val Val Val Met Thr
 210                 215                 220                 225

 ccc ttc gat gtg gtc agc acg cgg cta tac aat cag ccg gtg gac aca     1077
 Pro Phe Asp Val Val Ser Thr Arg Leu Tyr Asn Gln Pro Val Asp Thr
                 230                 235                 240

 gct ggc agg ggc cag ctc tat ggg ggc ctc acc gac tgc atg gtg aag     1125
 Ala Gly Arg Gly Gln Leu Tyr Gly Gly Leu Thr Asp Cys Met Val Lys
             245                 250                 255

 atc tgg cgg cag gag ggc ccc ctg gca ctc tac aag ggc ctg ggc ccc     1173
 Ile Trp Arg Gln Glu Gly Pro Leu Ala Leu Tyr Lys Gly Leu Gly Pro
         260                 265                 270

 gcc tac ctg cgc ctg ggc ccc cac acc atc ctc agc atg ctc ttc tgg     1221
 Ala Tyr Leu Arg Leu Gly Pro His Thr Ile Leu Ser Met Leu Phe Trp
     275                 280                 285

 gac gag ctt cgg aaa ctg gct ggg cgg gcc cag cac aag ggc acc tag     1269
 Asp Glu Leu Arg Lys Leu Ala Gly Arg Ala Gln His Lys Gly Thr 
 290                 295                 300

 acgacggccc tcacccccac gtcctgacac ggccggcact tggccggaag tgagagcctg   1329

 ctccaggaca actggctgtc ccggggcggg ccatgggccc aggccctgcc agaggtcccg   1389

 ggagagtgtg gacagctctg gtccatccag ccccttggcc cacccaggtc cagagcatcc   1449

 acttcaagtt accacccatt ctgtcttcca gacagttctc ttccttctct gtactgcgta   1509

 ctgggtcacc acatcccaga gccttgctca gttatagcaa ctgctgcggg cgtgcacatg   1569

 gcataggccc agtaacttac atacatcggc tcacttaggc ctcagacagc agcacgaggc   1629

 aggcactttt acttctttta ccattagaaa gccaaggcct agagtggtgg gctttgacca   1689

 cagccacaca attttgaagt ggcagagcca ggactggagc ttagccctgc tcaccctaga   1749

 cctatgcgct tgacaagtgc gtgactgtga caggcccatg ggcccggact gcccataggg   1809

 gtcactgtac catggcaaag gctgaggtgc accaggaggc tgtggcgtcg tcacctgcct   1869

 tatttgctgg agaa                                                     1883




      <210> 410
      <211> 1460
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(1460)

      <400> 410
 cagggtctga attattcaaa cgtagtctc  atg tct gga ttg gaa caa atg gaa      53
                                  Met Ser Gly Leu Glu Gln Met Glu
                                    1               5

 gag ctg agg aca gga gtg aca gga gtt ctg cag gaa ttg gat ttg caa      101
 Glu Leu Arg Thr Gly Val Thr Gly Val Leu Gln Glu Leu Asp Leu Gln
      10                  15                  20

 ctc aaa acc aaa ggc tcc cca ctg ctg caa gat att tct gca gaa aga      149
 Leu Lys Thr Lys Gly Ser Pro Leu Leu Gln Asp Ile Ser Ala Glu Arg
  25                  30                  35                  40

 tca cca aat gga gta caa ttg gag aga agc aat act gca gag aaa ctg      197
 Ser Pro Asn Gly Val Gln Leu Glu Arg Ser Asn Thr Ala Glu Lys Leu
                  45                  50                  55

 tat gac tct aac cat tct gga aaa gtc ttc aat gaa cac cca ttt ctt      245
 Tyr Asp Ser Asn His Ser Gly Lys Val Phe Asn Glu His Pro Phe Leu
              60                  65                  70

 atg act cac atg ata act cac att gga gag aaa act tct gag gat aat      293
 Met Thr His Met Ile Thr His Ile Gly Glu Lys Thr Ser Glu Asp Asn
          75                  80                  85

 cag agt gga aaa gcc tta aga aag aac ttt cct cat agt ttt tac aag      341
 Gln Ser Gly Lys Ala Leu Arg Lys Asn Phe Pro His Ser Phe Tyr Lys
      90                  95                 100

 aaa agt cat gct gag ggg aaa atg cct aag tgt gtt aaa cat gaa aaa      389
 Lys Ser His Ala Glu Gly Lys Met Pro Lys Cys Val Lys His Glu Lys
 105                 110                 115                 120

 gcc ttc aac cag ttt cca aat ctt act agg cag aat aaa act cac aca      437
 Ala Phe Asn Gln Phe Pro Asn Leu Thr Arg Gln Asn Lys Thr His Thr
                 125                 130                 135

 caa gag aaa ttg tgt gaa tgc aaa gac tgt tgg aga act ttt ctt aat      485
 Gln Glu Lys Leu Cys Glu Cys Lys Asp Cys Trp Arg Thr Phe Leu Asn
             140                 145                 150

 cag tca tcc ctt aag tta cat ata aga tct cac aat gga gac aaa cac      533
 Gln Ser Ser Leu Lys Leu His Ile Arg Ser His Asn Gly Asp Lys His
         155                 160                 165

 tat gta tgt aag gaa tgt ggg aaa gcc ttc agt aat tcc tca cac ctt      581
 Tyr Val Cys Lys Glu Cys Gly Lys Ala Phe Ser Asn Ser Ser His Leu
     170                 175                 180

 ata gga cat gga aga att cac agt gga gag aag ccc tat gtc tgt aaa      629
 Ile Gly His Gly Arg Ile His Ser Gly Glu Lys Pro Tyr Val Cys Lys
 185                 190                 195                 200

 gaa tgt ggt aaa gct ttc act caa tcc aca gga ctt aaa tta cac atc      677
 Glu Cys Gly Lys Ala Phe Thr Gln Ser Thr Gly Leu Lys Leu His Ile
                 205                 210                 215

 aga act cac agt gga gaa aaa cca tat aaa tgt aaa gag tgt ggg aaa      725
 Arg Thr His Ser Gly Glu Lys Pro Tyr Lys Cys Lys Glu Cys Gly Lys
             220                 225                 230

 gcc ttc acc cat tct tca tac ctt act gat cat aca aga atc cac agt      773
 Ala Phe Thr His Ser Ser Tyr Leu Thr Asp His Thr Arg Ile His Ser
         235                 240                 245

 gga aag aag ccc tat gta tgt atg gaa tgt gga aaa gcc ttc act aga      821
 Gly Lys Lys Pro Tyr Val Cys Met Glu Cys Gly Lys Ala Phe Thr Arg
     250                 255                 260

 tcc aca gga ctt att tta cac atg cga att cac act gga gaa aag cca      869
 Ser Thr Gly Leu Ile Leu His Met Arg Ile His Thr Gly Glu Lys Pro
 265                 270                 275                 280

 tat gaa tgt aag gag tgt gga aaa gct ttt att cat tcc tca tac ctt      917
 Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Ile His Ser Ser Tyr Leu
                 285                 290                 295

 aca aaa cat gta agg att cac agt gga gag aag ctg tat tta tgt aag      965
 Thr Lys His Val Arg Ile His Ser Gly Glu Lys Leu Tyr Leu Cys Lys
             300                 305                 310

 gca tgt ggg aaa gct ttt act cgt tcc tca gga ctt gtt tta cac atg     1013
 Ala Cys Gly Lys Ala Phe Thr Arg Ser Ser Gly Leu Val Leu His Met
         315                 320                 325

 aga aca cat act gga gaa aag ccc tat gaa tgt aaa gaa tgt ggg aaa     1061
 Arg Thr His Thr Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys
     330                 335                 340

 gcc ttt aat aat tcc tca atg ctt agt caa cat gta agg att cac act     1109
 Ala Phe Asn Asn Ser Ser Met Leu Ser Gln His Val Arg Ile His Thr
 345                 350                 355                 360

 gga gag aag cca tat gaa tgc aaa gaa tgt ggg aaa gct ttc act caa     1157
 Gly Glu Lys Pro Tyr Glu Cys Lys Glu Cys Gly Lys Ala Phe Thr Gln
                 365                 370                 375

 tcc tcg ggc ctt agt acc cat tta aga act cac act gga gaa aag gcc     1205
 Ser Ser Gly Leu Ser Thr His Leu Arg Thr His Thr Gly Glu Lys Ala
             380                 385                 390

 tgt gaa tgt aag gaa tgc ggt aaa gca ttt gct cgt tcc aca aat ctt     1253
 Cys Glu Cys Lys Glu Cys Gly Lys Ala Phe Ala Arg Ser Thr Asn Leu
         395                 400                 405

 aat atg cac atg cga acg cac aca gga gaa aag cct tat gca tgt aaa     1301
 Asn Met His Met Arg Thr His Thr Gly Glu Lys Pro Tyr Ala Cys Lys
     410                 415                 420

 gaa tgt ggg aaa gcc ttc agg tat tcc aca tac ctt aac gtt cac aca     1349
 Glu Cys Gly Lys Ala Phe Arg Tyr Ser Thr Tyr Leu Asn Val His Thr
 425                 430                 435                 440

 cga act cac act gga gca aaa cca tat gaa tgt aag aaa tgt ggg aaa     1397
 Arg Thr His Thr Gly Ala Lys Pro Tyr Glu Cys Lys Lys Cys Gly Lys
                 445                 450                 455

 aac ttc act caa tct tca gca ctt gct aaa cat cta aga act aag gca     1445
 Asn Phe Thr Gln Ser Ser Ala Leu Ala Lys His Leu Arg Thr Lys Ala
             460                 465                 470

 tgt gaa aaa acc tga                                                 1460
 Cys Glu Lys Thr 
         475





      <210> 411
      <211> 522
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (223)..(522)

      <400> 411
 tttcgtagca ttctccttat ctcatctgca caggaagcag gtctaagtgt aatttcacaa     60

 gcccctgact ctgtatagac acccagctct ccagaaaaat gctttgaaga caaaggatac    120

 agcatacagt cccgtgtctc ggctgagtca tcgcattcct taatagtgtc ttctccccgg    180

 gtttggtggc ctgcttctgg agtggtcagt tctgctgccg ac   atg ccc acc cag     234
                                                  Met Pro Thr Gln
                                                    1

 ctc gag atg gcc atg gac acc atg att aga atc ttc cac cgc tat tct      282
 Leu Glu Met Ala Met Asp Thr Met Ile Arg Ile Phe His Arg Tyr Ser
   5                  10                  15                  20

 ggc aag gca agg aag aga ttc aag ctc agc aag ggg gaa ctg aaa ctg      330
 Gly Lys Ala Arg Lys Arg Phe Lys Leu Ser Lys Gly Glu Leu Lys Leu
                  25                  30                  35

 ctc ctg cag cga gag ctc acg gaa ttc ctc tcg tgc caa aag gaa acc      378
 Leu Leu Gln Arg Glu Leu Thr Glu Phe Leu Ser Cys Gln Lys Glu Thr
              40                  45                  50

 cag ttg gtt gat aag ata gtg cag gac ctg gat gcc aat aag gac aac      426
 Gln Leu Val Asp Lys Ile Val Gln Asp Leu Asp Ala Asn Lys Asp Asn
          55                  60                  65

 gaa gtg gat ttt aat gaa ttc gtg gtc atg gtg gca gct ctg aca gtt      474
 Glu Val Asp Phe Asn Glu Phe Val Val Met Val Ala Ala Leu Thr Val
      70                  75                  80

 gct tgt aat gat tac ttt gta gaa caa ttg aag aag aaa gga aaa taa      522
 Ala Cys Asn Asp Tyr Phe Val Glu Gln Leu Lys Lys Lys Gly Lys 
  85                  90                  95





      <210> 412
      <211> 1232
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (240)..(1097)

      <400> 412
 cgggtcaagg tccgcgggcc tcgcagattg tagcccgttc gcacgcgatc agatgatcct     60

 gttgtggacg gctaagttgt aggcgggatg gctgagaaag cggcgctagg acccccgggc    120

 agaggctcgg ggaagggagt caggggggaa atgccttaca aggtcgcctt gcggtcacca    180

 tcattgcccg ccgcccaaaa tagcccccgg cgccagctgg cctgccctat ggccgagag     239                                                                 
 atg gct gct gcc tcc gag ccc gtg gat tcg ggt gca ctc tgg gga ctc      287
 Met Ala Ala Ala Ser Glu Pro Val Asp Ser Gly Ala Leu Trp Gly Leu
   1               5                  10                  15

 gag cgc ccg gag ccc cct ccc acc cgc ttc cat cgg gtg cac ggt gcc      335
 Glu Arg Pro Glu Pro Pro Pro Thr Arg Phe His Arg Val His Gly Ala
              20                  25                  30

 aac atc cgc gtg gac ccc tct ggg acg cgg gcc aca cgc gtg gag agc      383
 Asn Ile Arg Val Asp Pro Ser Gly Thr Arg Ala Thr Arg Val Glu Ser
          35                  40                  45

 ttc gcc cac ggc gtg tgc ttc agc cgc gag ccg ctg gcc ccg ggc cag      431
 Phe Ala His Gly Val Cys Phe Ser Arg Glu Pro Leu Ala Pro Gly Gln
      50                  55                  60

 gtc ttc ctg gtc gag atc gag gag aaa gag ctg ggc tgg tgc gga cat      479
 Val Phe Leu Val Glu Ile Glu Glu Lys Glu Leu Gly Trp Cys Gly His
  65                  70                  75                  80

 ctg cgt ctc ggt ctg acc gcg ctg gac ccc gcc agt ctg gcc ccc gtt      527
 Leu Arg Leu Gly Leu Thr Ala Leu Asp Pro Ala Ser Leu Ala Pro Val
                  85                  90                  95

 ccc gag ttt tct ctg ccc gat ctg gtc aac ctg ggc cac acc tgg gtc      575
 Pro Glu Phe Ser Leu Pro Asp Leu Val Asn Leu Gly His Thr Trp Val
             100                 105                 110

 ttc gcc atc acg cgc cac cac aac cgc gtg ccc cgg gag ggc cgc ccg      623
 Phe Ala Ile Thr Arg His His Asn Arg Val Pro Arg Glu Gly Arg Pro
         115                 120                 125

 gag gcg gag gca gcg gcc ccc agc cga cct cca acc ctc ctc gtg gaa      671
 Glu Ala Glu Ala Ala Ala Pro Ser Arg Pro Pro Thr Leu Leu Val Glu
     130                 135                 140

 cca tat ctg cgc att gag cag ttt cgc att ccc cgg gac cgc ctg gtg      719
 Pro Tyr Leu Arg Ile Glu Gln Phe Arg Ile Pro Arg Asp Arg Leu Val
 145                 150                 155                 160

 ggc cgc agc cgg cca ggg ctc tac agc cat ctc ttg gac cag ctc tat      767
 Gly Arg Ser Arg Pro Gly Leu Tyr Ser His Leu Leu Asp Gln Leu Tyr
                 165                 170                 175

 gag ctg aac gtg ctg cct ccg acc gcg cgc cgt agc cgc ctg ggt gtc      815
 Glu Leu Asn Val Leu Pro Pro Thr Ala Arg Arg Ser Arg Leu Gly Val
             180                 185                 190

 ctc ttt tgc ccg cgc ccc gat ggc acg gcc gac atg cac atc atc atc      863
 Leu Phe Cys Pro Arg Pro Asp Gly Thr Ala Asp Met His Ile Ile Ile
         195                 200                 205

 aac ggc gag gac atg ggc ccg agc gcc cgg gga ctg cca gct gcg cag      911
 Asn Gly Glu Asp Met Gly Pro Ser Ala Arg Gly Leu Pro Ala Ala Gln
     210                 215                 220

 ccc ctc tac gcg gtg gtg gac gtg ttt gct tcc aca aag agc gtg cgc      959
 Pro Leu Tyr Ala Val Val Asp Val Phe Ala Ser Thr Lys Ser Val Arg
 225                 230                 235                 240

 ctt gtc cag ctc gag tat ggc ttg cca tcc ctg cag act ctg tgc cgc     1007
 Leu Val Gln Leu Glu Tyr Gly Leu Pro Ser Leu Gln Thr Leu Cys Arg
                 245                 250                 255

 cta gtg ata caa agg agc atg gtg cac cgg ctg gcc att gat ggg ctc     1055
 Leu Val Ile Gln Arg Ser Met Val His Arg Leu Ala Ile Asp Gly Leu
             260                 265                 270

 cac ctg ccc aaa gaa ctt aag gat ttc tgc aag tat gag tga agaccca     1104
 His Leu Pro Lys Glu Leu Lys Asp Phe Cys Lys Tyr Glu 
         275                 280                 285

 cagtgcacca gagcacagct gcatcctggg gccccagacc tgtggctggc tggtccgaag   1164

 ttggccacat tgctgccagc caagaccaga aataaacagc cgatgctgac atcttgaaaa   1224

 aaaaaaaa                                                            1232




      <210> 413
      <211> 2560
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (233)..(1321)

      <400> 413
 aatgatgaaa tcccctgatg aaaaacctaa cacatttctt agaatgtatg cctgttcttt     60

 agtgatgcat gactgttttt gacttcttat ataactcacg gaagagctgt ttaggtttgg    120

 atgatacatc tctagatcac tatgaatctc tggtggaaga aagacctaaa atcaacttat    180

 agggtgggat attattattt taccatttta ccactttcta tgttaaaatg tt    atg     235
                                                              Met
                                                                1

 tcg tat cgt aaa tta aca ttg ttt ttc tca ata gct gtt cgt gat cgc      283
 Ser Tyr Arg Lys Leu Thr Leu Phe Phe Ser Ile Ala Val Arg Asp Arg
               5                  10                  15

 atg gtc cct cct cca cca cca ccc cac cat ctc tat gcg aag gct aac      331
 Met Val Pro Pro Pro Pro Pro Pro His His Leu Tyr Ala Lys Ala Asn
          20                  25                  30

 acc tca tct tcc atc ttc ctg cac tgg agg agg cct gca ttc acc gct      379
 Thr Ser Ser Ser Ile Phe Leu His Trp Arg Arg Pro Ala Phe Thr Ala
      35                  40                  45

 gca caa atc att aac tac acc atc cgc tgt aat cct gtt ggc ctg cag      427
 Ala Gln Ile Ile Asn Tyr Thr Ile Arg Cys Asn Pro Val Gly Leu Gln
  50                  55                  60                  65

 aat gct tct ttg gtt ctg tac ctt caa aca tca gaa act cac atg ttg      475
 Asn Ala Ser Leu Val Leu Tyr Leu Gln Thr Ser Glu Thr His Met Leu
                  70                  75                  80

 gtt caa ggt cta gaa cca aac acc aaa tac gaa ttt gcc gtt cga tta      523
 Val Gln Gly Leu Glu Pro Asn Thr Lys Tyr Glu Phe Ala Val Arg Leu
              85                  90                  95

 cat gtg gat cag ctt tcc agt cct tgg agc cct gta gtc tac cat tct      571
 His Val Asp Gln Leu Ser Ser Pro Trp Ser Pro Val Val Tyr His Ser
         100                 105                 110

 act ctt cca gaa gca cca gca ggc cca cca gtt gga gta aaa gtg aca      619
 Thr Leu Pro Glu Ala Pro Ala Gly Pro Pro Val Gly Val Lys Val Thr
     115                 120                 125

 tta ata gag gat gac act gcc ctg gtt tct tgg aaa ccc cct gat ggc      667
 Leu Ile Glu Asp Asp Thr Ala Leu Val Ser Trp Lys Pro Pro Asp Gly
 130                 135                 140                 145

 cca gaa aca gtt gtg acc cgc tat act atc tta tat gca tct agg aag      715
 Pro Glu Thr Val Val Thr Arg Tyr Thr Ile Leu Tyr Ala Ser Arg Lys
                 150                 155                 160

 gcc tgg att gca gga gag tgg cag gtc tta cac cgt gaa gca aaa gca      763
 Ala Trp Ile Ala Gly Glu Trp Gln Val Leu His Arg Glu Ala Lys Ala
             165                 170                 175

 cca ccc cca aaa caa gac ttt act caa gga gca acc aaa aac act aat      811
 Pro Pro Pro Lys Gln Asp Phe Thr Gln Gly Ala Thr Lys Asn Thr Asn
         180                 185                 190

 caa aat tcc tct gct cat cca cct cac ttg aat atg gat gac aca gtg      859
 Gln Asn Ser Ser Ala His Pro Pro His Leu Asn Met Asp Asp Thr Val
     195                 200                 205

 aat cag agt aat att gaa tta aaa aat gtt aat cga aac aat gca gta      907
 Asn Gln Ser Asn Ile Glu Leu Lys Asn Val Asn Arg Asn Asn Ala Val
 210                 215                 220                 225

 aat cag gag aac agc cgt tca agt agc act gaa gcc aca aac aat aac      955
 Asn Gln Glu Asn Ser Arg Ser Ser Ser Thr Glu Ala Thr Asn Asn Asn
                 230                 235                 240

 cct gca aat ggg acg cag aat aag cca cga caa cca aga ggt gca gca     1003
 Pro Ala Asn Gly Thr Gln Asn Lys Pro Arg Gln Pro Arg Gly Ala Ala
             245                 250                 255

 gat gcc tgc acc aca gaa aaa agc aat aaa tcc tct ctt cac cca aac     1051
 Asp Ala Cys Thr Thr Glu Lys Ser Asn Lys Ser Ser Leu His Pro Asn
         260                 265                 270

 cgt cat ggc cat tcg tct tct gac cca gtg tat cct tgt gga att tgt     1099
 Arg His Gly His Ser Ser Ser Asp Pro Val Tyr Pro Cys Gly Ile Cys
     275                 280                 285

 aca aac gag gtg aac gat gat cag gat gcc atc tta tgt gag gcc tct     1147
 Thr Asn Glu Val Asn Asp Asp Gln Asp Ala Ile Leu Cys Glu Ala Ser
 290                 295                 300                 305

 tgt cag aaa tgg ttt cat cgg atc tgt act gga atg act gaa aca gct     1195
 Cys Gln Lys Trp Phe His Arg Ile Cys Thr Gly Met Thr Glu Thr Ala
                 310                 315                 320

 tat ggc ctc tta act gca gaa gca tct gca gta tgg ggc tgt gat acc     1243
 Tyr Gly Leu Leu Thr Ala Glu Ala Ser Ala Val Trp Gly Cys Asp Thr
             325                 330                 335

 tgt atg gct gac aaa gat gtc cag tta atg cgt act aga gaa act ttt     1291
 Cys Met Ala Asp Lys Asp Val Gln Leu Met Arg Thr Arg Glu Thr Phe
         340                 345                 350

 ggt cca tct gca gtg ggc agt gat gct taa t caaaggcatt aactaaagtg     1342
 Gly Pro Ser Ala Val Gly Ser Asp Ala 
     355                 360

 ggtttatttt cctgtgcatt gcagaagttc attgacacag gattttaatg ttttacatta   1402

 tttttttaaa tgcatacaca aaaacattat ttacttagtt tttattaatc acttcatcac   1462

 tagagcaaat tttttattgt ctttgcttgc tgtcttaaat gagaataatg tatatggggg   1522

 tgctttagaa acataaataa atgttagttg ttgttattta tcacaaacat aaaagcctct   1582

 tgaaacttca aaataatata taacaaatgt aggcaagttt taacttttaa aagttagaat   1642

 cattgaaaaa catgtatttc agtgctgaac tttggttgta ccatattaaa gatttagttc   1702

 aaaaagttta tcaaggatcc acttaacacg tcttcacaac ataatatatg taactgtaac   1762

 atgggggaga gcatacattt ttatggatta aaaaaataat agtatgacac cagattcctc   1822

 ctccactagg gtctttggaa tcaatgaatt tcatatttca agtgagtttt caggatatct   1882

 gtttgtacag atacgagaca gatcttagca tatagtaaat tctcagtaag tattgttgat   1942

 taacttgtgg atggtaccac atgaaattgc taatattaga tcagttgaaa attgactgca   2002

 attagtaaag ttggtataac gtacgttccc agttgtgcta tttagaatta tgatagtatt   2062

 atgctcctac ttttctttga tattgagttg tcttgttatt gtttattgtt ttccagagaa   2122

 atactatagt atccacagaa gaattgtgaa tactttttta taattttgaa ctgggacata   2182

 ttgcagatga ggaaggtaga aacatccatt tggccttaga gggctctgct agtaaaagaa   2242

 ctactcagtg gtggtttgaa aaatcttgtt ctggggatct gaatttcaaa aatgaaccct   2302

 aggggagatc aaaatccatt ttaaacaaag atcaattaag agccaaagtg aaatctaact   2362

 tgcaaacaac aatttgaagc cttgcagcag acttaaggaa ttcccgctct gactggggaa   2422

 aagtataaaa atggacctga gagtaccctc tcgagggatg atcaagaatg gagacagttg   2482

 gaggtgtgct cattaagatt caaaacagca gaaatccatt tttggagcag attataacct   2542

 gtggccaaaa aaaaaaaa                                                 2560




      <210> 414
      <211> 3275
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (398)..(2863)

      <400> 414
 gctggcacca tgcccccccc tgcagaggtg acggacccgt cccatgcccc cgccgtcctg     60

 cgccagctca atgaacagcg gctccgtggc ctcttctgtg acgtcaccct catagccgga    120

 gacaccaagt tccctgctca ccgcagcgtc ctggctgctt caacctctcc ccctgcttct    180

 tccccacccc cgggtcctgg agttgccagg agtcccagca gctgcgtttt ctgatgtcct    240

 caacttcatc tacagcgccc ggctcgcact gcctggtggt ggaggggacg gggcagctgt    300

 agcagagatt ggagctttgg ggcgccgtct gggcatctcc cgccttcagg gcctggggga    360

 gggaggtgat gcctgggtac ctcctacccc agccccc atg gcc acc tcg cag cct     415
                                          Met Ala Thr Ser Gln Pro
                                            1               5

 gaa gag gac agc ttt ggg ccc ggg ccc agg cca gct ggg gag tgg gag      463
 Glu Glu Asp Ser Phe Gly Pro Gly Pro Arg Pro Ala Gly Glu Trp Glu
              10                  15                  20

 ggt gac agg gct gag gcc cag gcc cct gac ttg cag tgc tcc ctg ccc      511
 Gly Asp Arg Ala Glu Ala Gln Ala Pro Asp Leu Gln Cys Ser Leu Pro
          25                  30                  35

 cgg cgg ccc ctc ccc tgc ccc cag tgt gga aaa agc ttc atc cat ccc      559
 Arg Arg Pro Leu Pro Cys Pro Gln Cys Gly Lys Ser Phe Ile His Pro
      40                  45                  50

 aaa cgg ctg cag acc cat gag gcc cag tgc cga cga ggg gcc agc acg      607
 Lys Arg Leu Gln Thr His Glu Ala Gln Cys Arg Arg Gly Ala Ser Thr
  55                  60                  65                  70

 cgg ggg tct aca ggg ctg gga gct ggg ggc gct ggc cct ggt ggt cct      655
 Arg Gly Ser Thr Gly Leu Gly Ala Gly Gly Ala Gly Pro Gly Gly Pro
                  75                  80                  85

 gca ggg gtg gac gcc tca gcc ctg cct cca cca gtg ggc ttc cga ggg      703
 Ala Gly Val Asp Ala Ser Ala Leu Pro Pro Pro Val Gly Phe Arg Gly
              90                  95                 100

 ggc ccc gag cac gtg gtg aag gtg gtg ggc ggc cac gtg ctg tat gtg      751
 Gly Pro Glu His Val Val Lys Val Val Gly Gly His Val Leu Tyr Val
         105                 110                 115

 tgc gcg gcc tgc gag cgt tcc tac gtg acc ctg tcc agt ctg aag aga      799
 Cys Ala Ala Cys Glu Arg Ser Tyr Val Thr Leu Ser Ser Leu Lys Arg
     120                 125                 130

 cac agc aat gta cac tcg tgg cgg agg aag tac ccc tgc cgc tat tgt      847
 His Ser Asn Val His Ser Trp Arg Arg Lys Tyr Pro Cys Arg Tyr Cys
 135                 140                 145                 150

 gag aaa gtg ttt gct ctg gcg gag tac cgc acg aag cat gaa gtg tgg      895
 Glu Lys Val Phe Ala Leu Ala Glu Tyr Arg Thr Lys His Glu Val Trp
                 155                 160                 165

 cac acg ggg gag cgc agg tac cag tgc atc ttc tgt tgg gag acc ttt      943
 His Thr Gly Glu Arg Arg Tyr Gln Cys Ile Phe Cys Trp Glu Thr Phe
             170                 175                 180

 gtc act tac tat aac ctg aag acc cac cag cga gcc ttc cac ggc att      991
 Val Thr Tyr Tyr Asn Leu Lys Thr His Gln Arg Ala Phe His Gly Ile
         185                 190                 195

 agc ccg ggc ctc ctt gcc agt gag aag aca ccc aat gga ggc tac aag     1039
 Ser Pro Gly Leu Leu Ala Ser Glu Lys Thr Pro Asn Gly Gly Tyr Lys
     200                 205                 210

 ccc aag ctc aat aca ctc aag ctc tac cgc ctg ctc ccc atg cgg gca     1087
 Pro Lys Leu Asn Thr Leu Lys Leu Tyr Arg Leu Leu Pro Met Arg Ala
 215                 220                 225                 230

 gcc aag cgg ccc tac aag acc tac agc cag gga gcc ccg gag gct ccc     1135
 Ala Lys Arg Pro Tyr Lys Thr Tyr Ser Gln Gly Ala Pro Glu Ala Pro
                 235                 240                 245

 ctt tct cca acc ctc aac aca ccg gcc cct gtg gca atg cca gcc agc     1183
 Leu Ser Pro Thr Leu Asn Thr Pro Ala Pro Val Ala Met Pro Ala Ser
             250                 255                 260

 ccg ccg cct ggg cct cca cct gcc cca gag cct ggc cct cca ccc tct     1231
 Pro Pro Pro Gly Pro Pro Pro Ala Pro Glu Pro Gly Pro Pro Pro Ser
         265                 270                 275

 gtc atc act ttt gcc cac cca gcc ccc tct gtc att gtc cat ggg ggc     1279
 Val Ile Thr Phe Ala His Pro Ala Pro Ser Val Ile Val His Gly Gly
     280                 285                 290

 agt agc agt ggt gga ggg ggg agt ggg acg gcc agc aca gga ggg tcc     1327
 Ser Ser Ser Gly Gly Gly Gly Ser Gly Thr Ala Ser Thr Gly Gly Ser
 295                 300                 305                 310

 caa gct gcc tcg gtt atc act tac act gct ccc ccg agg cca ccc aag     1375
 Gln Ala Ala Ser Val Ile Thr Tyr Thr Ala Pro Pro Arg Pro Pro Lys
                 315                 320                 325

 aaa cga gaa tac cca cct cct ccc cct gag cct gca gcc aca ccc acc     1423
 Lys Arg Glu Tyr Pro Pro Pro Pro Pro Glu Pro Ala Ala Thr Pro Thr
             330                 335                 340

 agc cca gcc aca gca gtc agc cca gcc acc gct gca ggg cca gcc atg     1471
 Ser Pro Ala Thr Ala Val Ser Pro Ala Thr Ala Ala Gly Pro Ala Met
         345                 350                 355

 gcc acc acc acg gag gag gcc aag ggc cgg aat cca cgg gct gga agg     1519
 Ala Thr Thr Thr Glu Glu Ala Lys Gly Arg Asn Pro Arg Ala Gly Arg
     360                 365                 370

 act ctg act tac aca gcc aag cca gtg ggc ggg att ggt gga ggt ggg     1567
 Thr Leu Thr Tyr Thr Ala Lys Pro Val Gly Gly Ile Gly Gly Gly Gly
 375                 380                 385                 390

 ggt ccc ccc aca ggg gct ggc cgg ggc ccc tct cag ctg cag gct cca     1615
 Gly Pro Pro Thr Gly Ala Gly Arg Gly Pro Ser Gln Leu Gln Ala Pro
                 395                 400                 405

 cct cca ctg tgt cag atc act gtg cga ata ggg gag gag gcc atc gtc     1663
 Pro Pro Leu Cys Gln Ile Thr Val Arg Ile Gly Glu Glu Ala Ile Val
             410                 415                 420

 aag cgc cgc atc tca gag act gac ctg cgt cct ggg gag ctg agc gga     1711
 Lys Arg Arg Ile Ser Glu Thr Asp Leu Arg Pro Gly Glu Leu Ser Gly
         425                 430                 435

 gag gag atg gag gag agt gag gag gac gaa gag gag gag gac gaa gag     1759
 Glu Glu Met Glu Glu Ser Glu Glu Asp Glu Glu Glu Glu Asp Glu Glu
     440                 445                 450

 gag gag gag gag gat gag gag gaa tca aag gct ggt ggg gag gac cag     1807
 Glu Glu Glu Glu Asp Glu Glu Glu Ser Lys Ala Gly Gly Glu Asp Gln
 455                 460                 465                 470

 ctc tgg agg ccc tac tac tcc tac aag cct aag cgc aag gct gga gct     1855
 Leu Trp Arg Pro Tyr Tyr Ser Tyr Lys Pro Lys Arg Lys Ala Gly Ala
                 475                 480                 485

 gct gga ggt gcc agt gtg ggg ggc agt ggg ctg ccc cga ggc cgc cgg     1903
 Ala Gly Gly Ala Ser Val Gly Gly Ser Gly Leu Pro Arg Gly Arg Arg
             490                 495                 500

 cca cca cgt tgg agg cag aag ctg gaa cgg agg agc tgg gag gaa acc     1951
 Pro Pro Arg Trp Arg Gln Lys Leu Glu Arg Arg Ser Trp Glu Glu Thr
         505                 510                 515

 cca gcg gcc gag agc cca gcg gga cgt gcc cgc aca gag cgg agg cac     1999
 Pro Ala Ala Glu Ser Pro Ala Gly Arg Ala Arg Thr Glu Arg Arg His
     520                 525                 530

 cga tgc ggg gac tgt gcc cag acc ttc acc acc ctg aga aag ctg cgg     2047
 Arg Cys Gly Asp Cys Ala Gln Thr Phe Thr Thr Leu Arg Lys Leu Arg
 535                 540                 545                 550

 aag cac caa gag gcc cac ggt ggg ggc tcc cac agc tcc cgg gcc gga     2095
 Lys His Gln Glu Ala His Gly Gly Gly Ser His Ser Ser Arg Ala Gly
                 555                 560                 565

 cgg agg ccc tcc acc cgc ttt acc tgc ccc cac tgc gcc aag gtg tgc     2143
 Arg Arg Pro Ser Thr Arg Phe Thr Cys Pro His Cys Ala Lys Val Cys
             570                 575                 580

 aag acc gca gct gcc ctg agc cgc cac ggg cag agg cat gct gct gag     2191
 Lys Thr Ala Ala Ala Leu Ser Arg His Gly Gln Arg His Ala Ala Glu
         585                 590                 595

 cgg ccc ggg ggc acc cca acc cct gtc att gcc tat tcc aag ggc agc     2239
 Arg Pro Gly Gly Thr Pro Thr Pro Val Ile Ala Tyr Ser Lys Gly Ser
     600                 605                 610

 gct ggc acc agg ccc ggg gat gtc aag gag gaa gcc ccc caa gag atg     2287
 Ala Gly Thr Arg Pro Gly Asp Val Lys Glu Glu Ala Pro Gln Glu Met
 615                 620                 625                 630

 caa gtc tcc tca tcc agc ggt gag gca ggt ggc ggg agc act gct gct     2335
 Gln Val Ser Ser Ser Ser Gly Glu Ala Gly Gly Gly Ser Thr Ala Ala
                 635                 640                 645

 gag gaa gct tcc gag acc gcc tca ctc cag gac cct atc att tca ggg     2383
 Glu Glu Ala Ser Glu Thr Ala Ser Leu Gln Asp Pro Ile Ile Ser Gly
             650                 655                 660

 ggt gag gag ccc cca gta gtg gca agc ggg ggc agc tat gta tac cca     2431
 Gly Glu Glu Pro Pro Val Val Ala Ser Gly Gly Ser Tyr Val Tyr Pro
         665                 670                 675

 cct gtg cag gaa ttt cca ctg gcc ttg att ggg ggc ggc cgg gaa cct     2479
 Pro Val Gln Glu Phe Pro Leu Ala Leu Ile Gly Gly Gly Arg Glu Pro
     680                 685                 690

 ggc ggt ggc agg gga aaa tct ggg agt gaa ggg cca gtg ggg gct ggt     2527
 Gly Gly Gly Arg Gly Lys Ser Gly Ser Glu Gly Pro Val Gly Ala Gly
 695                 700                 705                 710

 gag ggg gac cgg atg gag ggg ata ggg gct gcc aaa gtc act ttc tac     2575
 Glu Gly Asp Arg Met Glu Gly Ile Gly Ala Ala Lys Val Thr Phe Tyr
                 715                 720                 725

 cct gag ccc tac ccg ctc gtc tat ggc ccc cag ctc ctt gcc gcc tac     2623
 Pro Glu Pro Tyr Pro Leu Val Tyr Gly Pro Gln Leu Leu Ala Ala Tyr
             730                 735                 740

 cct tac aac ttc agt aac ttg gcc gct ctc ccg gtt gct ctc aac atg     2671
 Pro Tyr Asn Phe Ser Asn Leu Ala Ala Leu Pro Val Ala Leu Asn Met
         745                 750                 755

 gtc cta cct gat gag aag ggt gcg ggg gcc ctt ccc ttc cta cca ggg     2719
 Val Leu Pro Asp Glu Lys Gly Ala Gly Ala Leu Pro Phe Leu Pro Gly
     760                 765                 770

 gtc ttt ggc tac gca gtg aat cct caa gca gca ccc cct gcc cca cca     2767
 Val Phe Gly Tyr Ala Val Asn Pro Gln Ala Ala Pro Pro Ala Pro Pro
 775                 780                 785                 790

 aca cca cct ccc cca act ctt cct cca cca att ccc cct aag gga gaa     2815
 Thr Pro Pro Pro Pro Thr Leu Pro Pro Pro Ile Pro Pro Lys Gly Glu
                 795                 800                 805

 ggg gaa agg gca ggg gtt gag aga acc cag aag ggc gat gtg ggg tga     2863
 Gly Glu Arg Ala Gly Val Glu Arg Thr Gln Lys Gly Asp Val Gly 
             810                 815                 820

 accctggggc tcaatccccc tttcaccaga tgccaccctc cctgaacccc ccaccactac   2923

 cagctccctg gcctccctgc cccttgggag ccccttcaca ctcttgtgca gggacttggg   2983

 ggcccctgga gctcaggggt caggctgctt tgtgtgagat gtagttttcc catctcctgg   3043

 gaagggatct ttcgaggttc ccctctcagt cttcctccag ggaatggcct ccatgagggg   3103

 cagggccagc ttccatccct tctccacgcc ttggggcaac tgagcaatat acttaacctg   3163

 aatctctact cacagccccc accagctctg aatgtctaac ctgctaccct gattcgtgca   3223

 cctaggggaa accatctctc tcagtcgacg ggccgcgaat ttagtagtag ta           3275




      <210> 415
      <211> 1831
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (146)..(1561)

      <400> 415
 gaattcccgg gtcgacgatt tcgtcgcccc gcggagttcc atgggtcctg cacagcatca     60

 ggcctgagcc gccggtccaa ctgctccagg tcatcagttt gccccatcat tggttaaggt    120

 ggtattctct acattataaa gctcg  atg gag ttt gtg aca gcc ctg gtg aac     172
                              Met Glu Phe Val Thr Ala Leu Val Asn
                                1               5

 ctc caa gag gag tct agc tgt ccc atc tgt ctg gag tac ttg aaa gac      220
 Leu Gln Glu Glu Ser Ser Cys Pro Ile Cys Leu Glu Tyr Leu Lys Asp
  10                  15                  20                  25

 cca gtg acc atc aac tgt ggg cac aac ttc tgt cgc tcc tgc ctc agt      268
 Pro Val Thr Ile Asn Cys Gly His Asn Phe Cys Arg Ser Cys Leu Ser
                  30                  35                  40

 gta tcc tgg aag gat cta gat gat acc ttt ccc tgt cct gtc tgc cgt      316
 Val Ser Trp Lys Asp Leu Asp Asp Thr Phe Pro Cys Pro Val Cys Arg
              45                  50                  55

 ttt tgc ttt cca tac aag agc ttc agg agg aac ccc cag ctc cgt aat      364
 Phe Cys Phe Pro Tyr Lys Ser Phe Arg Arg Asn Pro Gln Leu Arg Asn
          60                  65                  70

 ttg act gaa att gct aaa caa ctc cag att agg agg agc aag aga aag      412
 Leu Thr Glu Ile Ala Lys Gln Leu Gln Ile Arg Arg Ser Lys Arg Lys
      75                  80                  85

 agg cag aaa gag aat gcc atg tgt gaa aaa cac aac cag ttt ctg acc      460
 Arg Gln Lys Glu Asn Ala Met Cys Glu Lys His Asn Gln Phe Leu Thr
  90                  95                 100                 105

 ctc ttc tgt gtt aaa gat cta gag atc tta tgt aca cag tgc agt ttc      508
 Leu Phe Cys Val Lys Asp Leu Glu Ile Leu Cys Thr Gln Cys Ser Phe
                 110                 115                 120

 tcc act aaa cac cag aag cac tac att tgc cct att aag aaa gct gcc      556
 Ser Thr Lys His Gln Lys His Tyr Ile Cys Pro Ile Lys Lys Ala Ala
             125                 130                 135

 tct tat cac aga gaa att cta gaa ggt agc ctt gag ccc ttg agg aat      604
 Ser Tyr His Arg Glu Ile Leu Glu Gly Ser Leu Glu Pro Leu Arg Asn
         140                 145                 150

 aat ata gaa cga gtt gaa aaa gtg ata att ctg caa ggc agc aaa tca      652
 Asn Ile Glu Arg Val Glu Lys Val Ile Ile Leu Gln Gly Ser Lys Ser
     155                 160                 165

 gtg gag ctg aaa aag aag gta gaa tat aag agg gaa gaa ata aat tct      700
 Val Glu Leu Lys Lys Lys Val Glu Tyr Lys Arg Glu Glu Ile Asn Ser
 170                 175                 180                 185

 gag ttt gag caa ata aga ttg ttt tta cag aat gaa caa gag atg att      748
 Glu Phe Glu Gln Ile Arg Leu Phe Leu Gln Asn Glu Gln Glu Met Ile
                 190                 195                 200

 ctt agg cag ata caa gat gaa gag atg aac att tta gca aaa cta aat      796
 Leu Arg Gln Ile Gln Asp Glu Glu Met Asn Ile Leu Ala Lys Leu Asn
             205                 210                 215

 gaa aac ctt gta gaa ctt tca gat tat gtt tcc aca tta aaa cat cta      844
 Glu Asn Leu Val Glu Leu Ser Asp Tyr Val Ser Thr Leu Lys His Leu
         220                 225                 230

 ctg agg gag gta gag ggc aag tct gtg cag tca aac ctg gaa tta ctg      892
 Leu Arg Glu Val Glu Gly Lys Ser Val Gln Ser Asn Leu Glu Leu Leu
     235                 240                 245

 aca caa gct aag agt atg cac cac aag tat caa aac cta aaa tgc cct      940
 Thr Gln Ala Lys Ser Met His His Lys Tyr Gln Asn Leu Lys Cys Pro
 250                 255                 260                 265

 gaa ctc ttt tca ttt aga tta aca aaa tat ggt ttc agt ctt cct cct      988
 Glu Leu Phe Ser Phe Arg Leu Thr Lys Tyr Gly Phe Ser Leu Pro Pro
                 270                 275                 280

 caa tat tct ggc ttg gac aga att atc aag cca ttt caa gta gat gtg     1036
 Gln Tyr Ser Gly Leu Asp Arg Ile Ile Lys Pro Phe Gln Val Asp Val
             285                 290                 295

 att cta gat ctc aac aca gca cat cct caa ctt ctt gtc tct gag gat     1084
 Ile Leu Asp Leu Asn Thr Ala His Pro Gln Leu Leu Val Ser Glu Asp
         300                 305                 310

 aga aaa gct gtg cga tat gaa aga aaa aaa cga aac att tgt tat gac     1132
 Arg Lys Ala Val Arg Tyr Glu Arg Lys Lys Arg Asn Ile Cys Tyr Asp
     315                 320                 325

 cca agg aga ttt tat gtc tgc cct gct gtc cta ggc tct cag aga ttt     1180
 Pro Arg Arg Phe Tyr Val Cys Pro Ala Val Leu Gly Ser Gln Arg Phe
 330                 335                 340                 345

 agt tct ggc cga cat tac tgg gaa gta gaa gtg gga aac aaa cct aaa     1228
 Ser Ser Gly Arg His Tyr Trp Glu Val Glu Val Gly Asn Lys Pro Lys
                 350                 355                 360

 tgg ata ttg ggt gtg tgt caa gac tgt ctt ctt agg aac tgg cag gat     1276
 Trp Ile Leu Gly Val Cys Gln Asp Cys Leu Leu Arg Asn Trp Gln Asp
             365                 370                 375

 cag cca tca gtt ctg ggc gga ttc tgg gca att ggg cga tac atg aag     1324
 Gln Pro Ser Val Leu Gly Gly Phe Trp Ala Ile Gly Arg Tyr Met Lys
         380                 385                 390

 agt ggt tat gtt gcg tca ggt cct aag aca acc cag ctt ctg cca gta     1372
 Ser Gly Tyr Val Ala Ser Gly Pro Lys Thr Thr Gln Leu Leu Pro Val
     395                 400                 405

 gta aaa ccc agt aaa att ggt att ttt ctg gac tat gaa ttg ggt gat     1420
 Val Lys Pro Ser Lys Ile Gly Ile Phe Leu Asp Tyr Glu Leu Gly Asp
 410                 415                 420                 425

 ctt tcc ttt tat aat atg aat gat agg tct att ctc tat act ttt aac     1468
 Leu Ser Phe Tyr Asn Met Asn Asp Arg Ser Ile Leu Tyr Thr Phe Asn
                 430                 435                 440

 gat tgt ttc aca gaa gcc gtt tgg cct tat ttc tat act gga aca gat     1516
 Asp Cys Phe Thr Glu Ala Val Trp Pro Tyr Phe Tyr Thr Gly Thr Asp
             445                 450                 455

 tcc gaa cct ctt aaa atc tgc tca gta tca gat tct gaa aga taa gga     1564
 Ser Glu Pro Leu Lys Ile Cys Ser Val Ser Asp Ser Glu Arg 
         460                 465                 470

 actggtaaat gggtctgttt cagtttttgt aggtaactta gccagtaaat ttaatctcat   1624

 ttctggactc tttaagtttt accactgaaa accagagtcg atttttctcc taaatttttg   1684

 gcaactataa gatgttcata atgccacttt catatattct atgaatatca attgtcaggt   1744

 gctttgattt ctaagataaa atattttaga attatgttac ttaacatgtc caataaaatg   1804

 ttttcaaatt gcaaaaaaaa aaaaaaa                                       1831




      <210> 416
      <211> 2162
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (364)..(2010)

      <400> 416
 atgactgtca ccaactcctt gcagggcagt cagcccggag atagagtaat caaggtggcc     60

 gagagcaggg gacagcgccc tggcgacctc ctcagggatc ctagattaac agtcgcgtcc    120

 tcaaacgcag catcctgcgt aaccgccaat ttcaaacttc caagacctgc cctgctgatt    180

 ttgcccttcc ctttttccct ccgtctggcc tcgctgttgc tggagaggcc aggtcctgcc    240

 tcagtgcttt tggcttggct gtttcgtttg ccacggatgt ctttctttcc ccagatatca    300

 acatggcttg ctggtcattc gcttcaggtc ttcaagtctt gggtcaaatg cgccagtggg    360

 gag  atg ttg aag ttc aaa tat gga gcg cgg aat cct ttg gat gct ggt     408
      Met Leu Lys Phe Lys Tyr Gly Ala Arg Asn Pro Leu Asp Ala Gly
        1               5                  10                  15

 gct gct gaa ccc att gcc agc cgg gcc tcc agg ctg aat ctg ttc ttc      456
 Ala Ala Glu Pro Ile Ala Ser Arg Ala Ser Arg Leu Asn Leu Phe Phe
                  20                  25                  30

 cag ggg aaa cca ccc ttt atg act caa cag cag atg tct cct ctt tcc      504
 Gln Gly Lys Pro Pro Phe Met Thr Gln Gln Gln Met Ser Pro Leu Ser
              35                  40                  45

 cga gaa ggg ata tta gat gcc ctc ttt gtt ctc ttt gaa gaa tgc agt      552
 Arg Glu Gly Ile Leu Asp Ala Leu Phe Val Leu Phe Glu Glu Cys Ser
          50                  55                  60

 cag cct gct ctg atg aag att aag cac gtg agc aac ttt gtc cgg aag      600
 Gln Pro Ala Leu Met Lys Ile Lys His Val Ser Asn Phe Val Arg Lys
      65                  70                  75

 tat tcc gac acc ata gct gag tta cag gag ctc cag cct tcg gca aag      648
 Tyr Ser Asp Thr Ile Ala Glu Leu Gln Glu Leu Gln Pro Ser Ala Lys
  80                  85                  90                  95

 gac ttc gaa gtc aga agt ctt gta ggt tgt ggt cac ttt gct gaa gtg      696
 Asp Phe Glu Val Arg Ser Leu Val Gly Cys Gly His Phe Ala Glu Val
                 100                 105                 110

 cag gtg gta aga gag aaa gca acc ggg gac atc tat gct atg aaa gtg      744
 Gln Val Val Arg Glu Lys Ala Thr Gly Asp Ile Tyr Ala Met Lys Val
             115                 120                 125

 atg aag aag aag gct tta ttg gcc cag gag cag gtt tca ttt ttt gag      792
 Met Lys Lys Lys Ala Leu Leu Ala Gln Glu Gln Val Ser Phe Phe Glu
         130                 135                 140

 gaa gag cgg aac ata tta tct cga agc aca agc ccg tgg atc ccc caa      840
 Glu Glu Arg Asn Ile Leu Ser Arg Ser Thr Ser Pro Trp Ile Pro Gln
     145                 150                 155

 tta cag tat gcc ttt cag gac aaa aat cac ctt tat ctg gtc atg gaa      888
 Leu Gln Tyr Ala Phe Gln Asp Lys Asn His Leu Tyr Leu Val Met Glu
 160                 165                 170                 175

 tat cag cct gga ggg gac ttg ctg tca ctt ttg aat aga tat gag gac      936
 Tyr Gln Pro Gly Gly Asp Leu Leu Ser Leu Leu Asn Arg Tyr Glu Asp
                 180                 185                 190

 cag tta gat gaa aac ctg ata cag ttt tac cta gct gag ctg att ttg      984
 Gln Leu Asp Glu Asn Leu Ile Gln Phe Tyr Leu Ala Glu Leu Ile Leu
             195                 200                 205

 gct gtt cac agc gtt cat ctg atg gga tac gtg cat cga gac atc aag     1032
 Ala Val His Ser Val His Leu Met Gly Tyr Val His Arg Asp Ile Lys
         210                 215                 220

 cct gag aac att ctc gtt gac cgc aca gga cac atc aag ctg gtg gat     1080
 Pro Glu Asn Ile Leu Val Asp Arg Thr Gly His Ile Lys Leu Val Asp
     225                 230                 235

 ttt gga tct gcc gcg aaa atg aat tca aac aag atg gtg aat gcc aaa     1128
 Phe Gly Ser Ala Ala Lys Met Asn Ser Asn Lys Met Val Asn Ala Lys
 240                 245                 250                 255

 ctc ccg att ggg acc cca gat tac atg gct cct gaa gtg ctg act gtg     1176
 Leu Pro Ile Gly Thr Pro Asp Tyr Met Ala Pro Glu Val Leu Thr Val
                 260                 265                 270

 atg aac ggg gat gga aaa ggc acc tac ggc ctg gac tgt gac tgg tgg     1224
 Met Asn Gly Asp Gly Lys Gly Thr Tyr Gly Leu Asp Cys Asp Trp Trp
             275                 280                 285

 tca gtg ggc gtg att gcc tat gag atg att tat ggg aga tcc ccc ttc     1272
 Ser Val Gly Val Ile Ala Tyr Glu Met Ile Tyr Gly Arg Ser Pro Phe
         290                 295                 300

 gca gag gga acc tct gcc aga acc ttc aat aac att atg aat ttc cag     1320
 Ala Glu Gly Thr Ser Ala Arg Thr Phe Asn Asn Ile Met Asn Phe Gln
     305                 310                 315

 gtg ttg gac aat cag ata aag aaa gac ctg gct gac aag gag aca ctg     1368
 Val Leu Asp Asn Gln Ile Lys Lys Asp Leu Ala Asp Lys Glu Thr Leu
 320                 325                 330                 335

 gag aac atg atg cag aga cac gag gag gag gcc cat gag aag ggc aaa     1416
 Glu Asn Met Met Gln Arg His Glu Glu Glu Ala His Glu Lys Gly Lys
                 340                 345                 350

 att ctc agc gaa cag aag gcg atg atc aat gct atg gat tcc aag atc     1464
 Ile Leu Ser Glu Gln Lys Ala Met Ile Asn Ala Met Asp Ser Lys Ile
             355                 360                 365

 aga tcc ctg gaa cag agg att gtg gaa ctg tct gaa gcc aat aaa ctt     1512
 Arg Ser Leu Glu Gln Arg Ile Val Glu Leu Ser Glu Ala Asn Lys Leu
         370                 375                 380

 gca gca aat agc agt ctt ttt acc caa agg aac atg aag gcc caa gaa     1560
 Ala Ala Asn Ser Ser Leu Phe Thr Gln Arg Asn Met Lys Ala Gln Glu
     385                 390                 395

 gag atg att tct gaa ctc agg caa cag aaa ttt tac ctg gag aca cag     1608
 Glu Met Ile Ser Glu Leu Arg Gln Gln Lys Phe Tyr Leu Glu Thr Gln
 400                 405                 410                 415

 gct ggg aag ttg gag gcc cag aac cga aaa ctg gag gag cag ctg gag     1656
 Ala Gly Lys Leu Glu Ala Gln Asn Arg Lys Leu Glu Glu Gln Leu Glu
                 420                 425                 430

 aag atc agc cac caa gac cac agt gac aag aat cgg ctg ctg gaa ctg     1704
 Lys Ile Ser His Gln Asp His Ser Asp Lys Asn Arg Leu Leu Glu Leu
             435                 440                 445

 gag aca aga ttg cgg gag gtc agt cta gag cac gag gag cag aaa ctg     1752
 Glu Thr Arg Leu Arg Glu Val Ser Leu Glu His Glu Glu Gln Lys Leu
         450                 455                 460

 gag ctc aag cgc cag ctc aca gag cta cag ctc tcc ctg cag gag cgc     1800
 Glu Leu Lys Arg Gln Leu Thr Glu Leu Gln Leu Ser Leu Gln Glu Arg
     465                 470                 475

 gag tca cag ttg aca gcc ctg cag gct gca cgg gcg gcc ctg gag agc     1848
 Glu Ser Gln Leu Thr Ala Leu Gln Ala Ala Arg Ala Ala Leu Glu Ser
 480                 485                 490                 495

 cag ctt cgc cag gcg aag aca gag ctg gaa gag acc aca gca gaa gct     1896
 Gln Leu Arg Gln Ala Lys Thr Glu Leu Glu Glu Thr Thr Ala Glu Ala
                 500                 505                 510

 gaa gag gag atc cag gca ctc acg gta ggt ctg ggg agc aac atc ttc     1944
 Glu Glu Glu Ile Gln Ala Leu Thr Val Gly Leu Gly Ser Asn Ile Phe
             515                 520                 525

 agg ttg cta aag gcc tca gct agg atg agt gtg gaa ctg gca ctg agt     1992
 Arg Leu Leu Lys Ala Ser Ala Arg Met Ser Val Glu Leu Ala Leu Ser
         530                 535                 540

 ata ctg gct cac cct tag aaattc caggagggaa aacatgatcc acaaagatat     2046
 Ile Leu Ala His Pro 
     545

 tcagtggcca ggaaattggc ttacataggc tgctgcttca ttggaactag tagatgagct   2106

 tggttggtta tattcaaact tttcttagta tcttgaatag ctcctccttt acttat       2162




      <210> 417
      <211> 916
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (103)..(828)

      <400> 417
 gcaaaaagga gaccagacag gaggcgtctg tagagatatc atgaacttca acttagcttt     60

 gttttccaga gactggagct aaactgggct ttcaacatca tc   atg aag ttt atc     114
                                                  Met Lys Phe Ile
                                                    1

 ctc ctc tgg gcc ctc ttg aat ctg act gtt gct ttg gcc ttt aat cca      162
 Leu Leu Trp Ala Leu Leu Asn Leu Thr Val Ala Leu Ala Phe Asn Pro
   5                  10                  15                  20

 gat tac aca gtc agc tcc act ccc cct tac ttg gtc tat ttg aaa tct      210
 Asp Tyr Thr Val Ser Ser Thr Pro Pro Tyr Leu Val Tyr Leu Lys Ser
                  25                  30                  35

 gac tac ttg ccc tgc gct gga gtc ctg atc cac ccg ctt tgg gtg atc      258
 Asp Tyr Leu Pro Cys Ala Gly Val Leu Ile His Pro Leu Trp Val Ile
              40                  45                  50

 aca gct gca cac tgc aat tta cca aag ctt cgg gtg ata ttg ggg gtt      306
 Thr Ala Ala His Cys Asn Leu Pro Lys Leu Arg Val Ile Leu Gly Val
          55                  60                  65

 aca atc cca gca gac tct aat gaa aag cat ctg caa gtg att ggc tat      354
 Thr Ile Pro Ala Asp Ser Asn Glu Lys His Leu Gln Val Ile Gly Tyr
      70                  75                  80

 gag aag atg att cat cat cca cac ttc tca gtc act tct att gat cat      402
 Glu Lys Met Ile His His Pro His Phe Ser Val Thr Ser Ile Asp His
  85                  90                  95                 100

 gac atc atg cta atc aag ctg aaa aca gag gct gaa ctc aat gac tat      450
 Asp Ile Met Leu Ile Lys Leu Lys Thr Glu Ala Glu Leu Asn Asp Tyr
                 105                 110                 115

 gtg aaa tta gcc aac ctg ccc tac caa act atc tct gaa aat acc atg      498
 Val Lys Leu Ala Asn Leu Pro Tyr Gln Thr Ile Ser Glu Asn Thr Met
             120                 125                 130

 tgc tct gtc tct acc tgg agc tac aat gtg tgt gat atc tac aaa gag      546
 Cys Ser Val Ser Thr Trp Ser Tyr Asn Val Cys Asp Ile Tyr Lys Glu
         135                 140                 145

 ccc gat tca ctg caa act gtg aac atc tct gta atc tcc aag cct cag      594
 Pro Asp Ser Leu Gln Thr Val Asn Ile Ser Val Ile Ser Lys Pro Gln
     150                 155                 160

 tgt cgc gat gcc tat aaa acc tac aac atc acg gaa aat atg ctg tgt      642
 Cys Arg Asp Ala Tyr Lys Thr Tyr Asn Ile Thr Glu Asn Met Leu Cys
 165                 170                 175                 180

 gtg ggc att gtg cca gga agg agg cag ccc tgc aag gaa gtt tct gct      690
 Val Gly Ile Val Pro Gly Arg Arg Gln Pro Cys Lys Glu Val Ser Ala
                 185                 190                 195

 gcc ccg gca atc tgc aat ggg atg ctt caa gga atc ctg tct ttt gcg      738
 Ala Pro Ala Ile Cys Asn Gly Met Leu Gln Gly Ile Leu Ser Phe Ala
             200                 205                 210

 gat gga tgt gtt ttg aga gct gat gtt ggc atc tat gcc aaa att ttt      786
 Asp Gly Cys Val Leu Arg Ala Asp Val Gly Ile Tyr Ala Lys Ile Phe
         215                 220                 225

 tac tat ata ccc tgg att gaa aat gta atc caa aat aac tga gctgtgg      835
 Tyr Tyr Ile Pro Trp Ile Glu Asn Val Ile Gln Asn Asn 
     230                 235                 240

 cagttgtgga ccatatgaca cagcttgtcc ccatcgttca cctttagaat taaatataaa    895

 ttaactcctc aaaaaaaaaa a                                              916




      <210> 418
      <211> 1197
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (197)..(1066)

      <400> 418
 tttcgtggct ccccgctccc attgtctcgg cagatgccgc ctggtccagc tatcgtgctc     60

 ggtattcagt tttccggagc agcgctcttt ctctggcccg cggagcggtc ccgcggccga    120

 gtaccggatt cccgagtttg ggaggctctg ctttcctcct taggacccac tttgccgtcc    180

 tggggtggct gcagtt    atg tcc gcg ctg cga cct ctc ctg ctt ctg ctg     229
                      Met Ser Ala Leu Arg Pro Leu Leu Leu Leu Leu
                        1               5                  10

 ctg cct ctg tgt ccc ggt cct ggt ccc gga ccc ggg agc gag gca aag      277
 Leu Pro Leu Cys Pro Gly Pro Gly Pro Gly Pro Gly Ser Glu Ala Lys
              15                  20                  25

 gtc acc cgg agt tgt gca gag acc cgg cag gtg ctg ggg gcc cgg gga      325
 Val Thr Arg Ser Cys Ala Glu Thr Arg Gln Val Leu Gly Ala Arg Gly
          30                  35                  40

 tat agc tta aac cta atc cct ccc gcc ctg atc tca ggt gag cac ctc      373
 Tyr Ser Leu Asn Leu Ile Pro Pro Ala Leu Ile Ser Gly Glu His Leu
      45                  50                  55

 cgg gtc tgt ccc cag gag tac acc tgc tgt tcc agt gag aca gag cag      421
 Arg Val Cys Pro Gln Glu Tyr Thr Cys Cys Ser Ser Glu Thr Glu Gln
  60                  65                  70                  75

 agg ctg atc agg gag act gag gcc acc ttc cga ggc ctg gtg gag gac      469
 Arg Leu Ile Arg Glu Thr Glu Ala Thr Phe Arg Gly Leu Val Glu Asp
                  80                  85                  90

 agc ggc tcc ttt ctg gtt cac aca ctg gct gcc agg cac aga aaa ttt      517
 Ser Gly Ser Phe Leu Val His Thr Leu Ala Ala Arg His Arg Lys Phe
              95                 100                 105

 gat gag ttt ttt ctg gag atg ctc tca gta gcc cag cac tct ctg acc      565
 Asp Glu Phe Phe Leu Glu Met Leu Ser Val Ala Gln His Ser Leu Thr
         110                 115                 120

 cag ctc ttc tcc cac tcc tac ggc cgc ctg tat gcc cag cac gcc ctc      613
 Gln Leu Phe Ser His Ser Tyr Gly Arg Leu Tyr Ala Gln His Ala Leu
     125                 130                 135

 ata ttc aat ggc ctg ttc tct cgg ctg cga gac ttc tat ggg gaa tct      661
 Ile Phe Asn Gly Leu Phe Ser Arg Leu Arg Asp Phe Tyr Gly Glu Ser
 140                 145                 150                 155

 ggt gag ggg ttg gat gac acc ctg gcg gat ttc tgg gca cag ctc ctg      709
 Gly Glu Gly Leu Asp Asp Thr Leu Ala Asp Phe Trp Ala Gln Leu Leu
                 160                 165                 170

 gag aga gtg ttc ccg ctg ctg cac cca cag tac agc ttc ccc cct gac      757
 Glu Arg Val Phe Pro Leu Leu His Pro Gln Tyr Ser Phe Pro Pro Asp
             175                 180                 185

 tac ctg ctc tgc ctc tca cgc ttg gcc tca tct acc gat ggc tct ctg      805
 Tyr Leu Leu Cys Leu Ser Arg Leu Ala Ser Ser Thr Asp Gly Ser Leu
         190                 195                 200

 cag ccc ttt ggg gac tca ccc cgc cgc ctc cgc ctg cag ata acc cgg      853
 Gln Pro Phe Gly Asp Ser Pro Arg Arg Leu Arg Leu Gln Ile Thr Arg
     205                 210                 215

 acc ctg gtg gct gcc cga gcc ttt gtg cag ggc ctg gag act gga aga      901
 Thr Leu Val Ala Ala Arg Ala Phe Val Gln Gly Leu Glu Thr Gly Arg
 220                 225                 230                 235

 aat gtg gtc agc gaa gcg ctt aag gtt gga ggg ggc ctg agt atg ggc      949
 Asn Val Val Ser Glu Ala Leu Lys Val Gly Gly Gly Leu Ser Met Gly
                 240                 245                 250

 agg gcc cag gga ggg aga ggt gga agt gag aga gac ccc aca agg aag      997
 Arg Ala Gln Gly Gly Arg Gly Gly Ser Glu Arg Asp Pro Thr Arg Lys
             255                 260                 265

 aaa cag cca cca gcc agc agg aca ggc ctt ggg ctc tgt ctg cct cca     1045
 Lys Gln Pro Pro Ala Ser Arg Thr Gly Leu Gly Leu Cys Leu Pro Pro
         270                 275                 280

 ggc cct ggt gtc cta gga tga at taggaaggag ggggctggag tgaaacctcc     1098
 Gly Pro Gly Val Leu Gly 
     285

 aatggtccac gatccatgat ctctgacccc ctcctcccct ctgtggaccc ataccctcct   1158

 cagtccccaa gggcctgctc atctccatag cagtaggag                          1197




      <210> 419
      <211> 902
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (37)..(528)

      <400> 419
 cttcagcaag ctacctgcag ccctctgtct gacatc  atg tcc ttc aac tgc tcc      54
                                          Met Ser Phe Asn Cys Ser
                                            1               5

 aca aga aat tgc tct tcc agg ccc att gga gga cgc tgc att gtt cca      102
 Thr Arg Asn Cys Ser Ser Arg Pro Ile Gly Gly Arg Cys Ile Val Pro
              10                  15                  20

 gtg gcc caa gtt acc acg act tcc acc act gat gct gac tgc ctg ggc      150
 Val Ala Gln Val Thr Thr Thr Ser Thr Thr Asp Ala Asp Cys Leu Gly
          25                  30                  35

 ggc atc tgt ttg ccc agt tcc ttc cag act ggc tct tgg ctc ctg gac      198
 Gly Ile Cys Leu Pro Ser Ser Phe Gln Thr Gly Ser Trp Leu Leu Asp
      40                  45                  50

 cac tgt caa gag acc tgc tgt gag ccc act gct tgc cag cca acc tgt      246
 His Cys Gln Glu Thr Cys Cys Glu Pro Thr Ala Cys Gln Pro Thr Cys
  55                  60                  65                  70

 tac cgg cga act tca tgt gtc tcc aac cct tgc cag gtg act tgc tct      294
 Tyr Arg Arg Thr Ser Cys Val Ser Asn Pro Cys Gln Val Thr Cys Ser
                  75                  80                  85

 cga caa act acc tgt att tcc aac ccc tgc tca act acc tac agc cgg      342
 Arg Gln Thr Thr Cys Ile Ser Asn Pro Cys Ser Thr Thr Tyr Ser Arg
              90                  95                 100

 ccg ctc acc ttt gtc tct agt gga agt cag ccc ctg gga ggc atc tcc      390
 Pro Leu Thr Phe Val Ser Ser Gly Ser Gln Pro Leu Gly Gly Ile Ser
         105                 110                 115

 agt gtc tgc caa cca gtg ggc ggc atc tct act gtc tgc caa cca gtg      438
 Ser Val Cys Gln Pro Val Gly Gly Ile Ser Thr Val Cys Gln Pro Val
     120                 125                 130

 gga gga gtc tct act gtc tgc cag cca gcc tgt ggg gtc tcc agg acg      486
 Gly Gly Val Ser Thr Val Cys Gln Pro Ala Cys Gly Val Ser Arg Thr
 135                 140                 145                 150

 tat cag cag tcc tgc gtg tcc agc tgc cga aga acc tgc taa gtgtgta      535
 Tyr Gln Gln Ser Cys Val Ser Ser Cys Arg Arg Thr Cys 
                 155                 160

 ggagccagtg agcgaatcaa gactccacga cctgccagct gtttccagga tcttccagca    595

 tgctgcttgt ccctgaatag ctcttcatag ctgacccttc ttgtgaccgc ctgactgctg    655

 gctactatcc atgcacacgc tgctttacac tctaaatttt ctgccagccc taacttgttt    715

 agggtgctac tgtgctgtga tgcctctggt gtgtccagaa gctttaccat ccacacccca    775

 gtctctgatg cttttgacat gttttcacct tgctgctgta tctcctggcc tctggctttg    835

 tgtctcacaa aaacagagct tgtctcaacc atgatttctc aataaaccct gcattagttg    895

 gcattgc                                                              902




      <210> 420
      <211> 3130
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (15)..(3083)

      <400> 420
 aatggattaa gaac  atg gag aag gcg aat aaa ctg gct gtc atc aag ttc      50
                  Met Glu Lys Ala Asn Lys Leu Ala Val Ile Lys Phe
                    1               5                  10

 tct gat agc aac tac atg agg atg ctg gaa aac gcg ctg cag tta ggc       98
 Ser Asp Ser Asn Tyr Met Arg Met Leu Glu Asn Ala Leu Gln Leu Gly
          15                  20                  25

 acc cct gtc ttg att gaa aac att gga gaa gag ctg gat gct tct atc      146
 Thr Pro Val Leu Ile Glu Asn Ile Gly Glu Glu Leu Asp Ala Ser Ile
      30                  35                  40

 gaa cct atc ttg ctc aag gca aca ttc aaa cag caa gga gtt gag tac      194
 Glu Pro Ile Leu Leu Lys Ala Thr Phe Lys Gln Gln Gly Val Glu Tyr
  45                  50                  55                  60

 atg agg ctg ggt gaa aac atc att gaa tat tcc agg gat ttt aag tta      242
 Met Arg Leu Gly Glu Asn Ile Ile Glu Tyr Ser Arg Asp Phe Lys Leu
                  65                  70                  75

 tac atc aca acc cgt ttg agg aat cca cat tac ctc cca gaa gtt gcc      290
 Tyr Ile Thr Thr Arg Leu Arg Asn Pro His Tyr Leu Pro Glu Val Ala
              80                  85                  90

 gtg aag gtc tgt ctc ctc aac ttc atg atc acc ccc ttg ggt ctc caa      338
 Val Lys Val Cys Leu Leu Asn Phe Met Ile Thr Pro Leu Gly Leu Gln
          95                 100                 105

 gat caa ctc ctt ggc atc gtg gct gcg aag gag aag cca gag ttg gaa      386
 Asp Gln Leu Leu Gly Ile Val Ala Ala Lys Glu Lys Pro Glu Leu Glu
     110                 115                 120

 gag aaa aag aac cag ttg att gtg gaa agt gcc aag aac aag aag cat      434
 Glu Lys Lys Asn Gln Leu Ile Val Glu Ser Ala Lys Asn Lys Lys His
 125                 130                 135                 140

 ctc aag gaa att gaa gat aag atc ttg gag gtt ctc tcc atg tcc aag      482
 Leu Lys Glu Ile Glu Asp Lys Ile Leu Glu Val Leu Ser Met Ser Lys
                 145                 150                 155

 ggt aac atc ctg gag gat gaa acc gcc atc aaa gtt ctg tcc tcc tcc      530
 Gly Asn Ile Leu Glu Asp Glu Thr Ala Ile Lys Val Leu Ser Ser Ser
             160                 165                 170

 aaa gtg cta tct gaa gag atc tca gag aaa cag aaa gtt gct tcc atg      578
 Lys Val Leu Ser Glu Glu Ile Ser Glu Lys Gln Lys Val Ala Ser Met
         175                 180                 185

 aca gaa acg cag att gac gag act cgg atg ggc tac aag cca gtg gct      626
 Thr Glu Thr Gln Ile Asp Glu Thr Arg Met Gly Tyr Lys Pro Val Ala
     190                 195                 200

 gtg cat tct gcc acc atc ttc ttt tgt atc tcg gac ctg gcc aac atc      674
 Val His Ser Ala Thr Ile Phe Phe Cys Ile Ser Asp Leu Ala Asn Ile
 205                 210                 215                 220

 gag ccg atg tac cag tac tcc ctg act tgg ttc ata aat ctc tac atg      722
 Glu Pro Met Tyr Gln Tyr Ser Leu Thr Trp Phe Ile Asn Leu Tyr Met
                 225                 230                 235

 cat tcc ttg acc cac agc acg aag agc gag gaa ctg aat ctg cgc atc      770
 His Ser Leu Thr His Ser Thr Lys Ser Glu Glu Leu Asn Leu Arg Ile
             240                 245                 250

 aag tac atc att gac cat ttc acc ctg agc atc tac aac aac gtg tgc      818
 Lys Tyr Ile Ile Asp His Phe Thr Leu Ser Ile Tyr Asn Asn Val Cys
         255                 260                 265

 cgt tct ctg ttt gag aag gac aag cta ctc ttc tct ctc ctc ctg acc      866
 Arg Ser Leu Phe Glu Lys Asp Lys Leu Leu Phe Ser Leu Leu Leu Thr
     270                 275                 280

 atc ggc atc atg aaa cag aag aag gaa att acg gag gag gtg tgg tac      914
 Ile Gly Ile Met Lys Gln Lys Lys Glu Ile Thr Glu Glu Val Trp Tyr
 285                 290                 295                 300

 ttc ctt ctc act gga ggc atc gca ctg gat aac ccc tac ccc aat cca      962
 Phe Leu Leu Thr Gly Gly Ile Ala Leu Asp Asn Pro Tyr Pro Asn Pro
                 305                 310                 315

 gct ccc caa tgg ctg tct gag aag gca tgg gca gag att gtc cgt gca     1010
 Ala Pro Gln Trp Leu Ser Glu Lys Ala Trp Ala Glu Ile Val Arg Ala
             320                 325                 330

 tct gcc tta ccc aaa ctg cat ggc ctg atg gag cat ttg gaa cag aac     1058
 Ser Ala Leu Pro Lys Leu His Gly Leu Met Glu His Leu Glu Gln Asn
         335                 340                 345

 ctg ggt gaa tgg aag ctg atc tat gac tcg gcc tgg ccc cat gag gag     1106
 Leu Gly Glu Trp Lys Leu Ile Tyr Asp Ser Ala Trp Pro His Glu Glu
     350                 355                 360

 caa ctc cct ggg tct tgg aag ttc tct caa gga ttg gag aag atg gtg     1154
 Gln Leu Pro Gly Ser Trp Lys Phe Ser Gln Gly Leu Glu Lys Met Val
 365                 370                 375                 380

 atc ctt cga tgt ttg cgg cct gac aaa atg gtg cca gcg gtc cgg gag     1202
 Ile Leu Arg Cys Leu Arg Pro Asp Lys Met Val Pro Ala Val Arg Glu
                 385                 390                 395

 ttc att gct gaa cat atg gga aag ctg tat atc gaa gcc cct acg ttc     1250
 Phe Ile Ala Glu His Met Gly Lys Leu Tyr Ile Glu Ala Pro Thr Phe
             400                 405                 410

 gat ctc cag gga tcc tac aat gat tcc agc tgc tgt gcg cct ttg att     1298
 Asp Leu Gln Gly Ser Tyr Asn Asp Ser Ser Cys Cys Ala Pro Leu Ile
         415                 420                 425

 ttt gtg ttg tct cca agt gca gac cca atg gca ggc ctg ctg aag ttt     1346
 Phe Val Leu Ser Pro Ser Ala Asp Pro Met Ala Gly Leu Leu Lys Phe
     430                 435                 440

 gct gat gat ctt ggt atg gga ggt acc aga aca cag acc atc tcc ctt     1394
 Ala Asp Asp Leu Gly Met Gly Gly Thr Arg Thr Gln Thr Ile Ser Leu
 445                 450                 455                 460

 ggc caa ggc caa ggc cct att gct gcc aaa atg atc aac aat gcc atc     1442
 Gly Gln Gly Gln Gly Pro Ile Ala Ala Lys Met Ile Asn Asn Ala Ile
                 465                 470                 475

 aaa gac ggg acc tgg gtg gtc tta cag aac tgc cac ctg gcc gca agc     1490
 Lys Asp Gly Thr Trp Val Val Leu Gln Asn Cys His Leu Ala Ala Ser
             480                 485                 490

 tgg atg cct acc ctg gag aag att tgt gag gag gtg att gtt cct gag     1538
 Trp Met Pro Thr Leu Glu Lys Ile Cys Glu Glu Val Ile Val Pro Glu
         495                 500                 505

 agc acc aat gcc aga ttc aga ctc tgg cta acc agc tat cca tca gag     1586
 Ser Thr Asn Ala Arg Phe Arg Leu Trp Leu Thr Ser Tyr Pro Ser Glu
     510                 515                 520

 aag ttt cca gtc agc att ctc cag aat gga atc aaa atg acc aat gag     1634
 Lys Phe Pro Val Ser Ile Leu Gln Asn Gly Ile Lys Met Thr Asn Glu
 525                 530                 535                 540

 ccc ccc aaa ggg ctc cgg gcc aac ctg ttg cgc tcc tac ctc aat gac     1682
 Pro Pro Lys Gly Leu Arg Ala Asn Leu Leu Arg Ser Tyr Leu Asn Asp
                 545                 550                 555

 ccc atc tca gat cct gtg ttc ttc caa agc tgt gca aag gcg gtg atg     1730
 Pro Ile Ser Asp Pro Val Phe Phe Gln Ser Cys Ala Lys Ala Val Met
             560                 565                 570

 tgg caa aag atg tta ttt ggc ctt tgt ttc ttc cac gcc gtt gtt caa     1778
 Trp Gln Lys Met Leu Phe Gly Leu Cys Phe Phe His Ala Val Val Gln
         575                 580                 585

 gag aga aga aac ttc ggc ccc cta ggg tgg aat att ccc tat gaa ttc     1826
 Glu Arg Arg Asn Phe Gly Pro Leu Gly Trp Asn Ile Pro Tyr Glu Phe
     590                 595                 600

 aac gaa tct gac ctg agg att agt atg tgg cag atc cag atg ttt ctc     1874
 Asn Glu Ser Asp Leu Arg Ile Ser Met Trp Gln Ile Gln Met Phe Leu
 605                 610                 615                 620

 aat gac tac aag gag gtg ccc ttt gat gct ctg acc tac ctg aca ggg     1922
 Asn Asp Tyr Lys Glu Val Pro Phe Asp Ala Leu Thr Tyr Leu Thr Gly
                 625                 630                 635

 gaa tgt aat tac gga ggc aga gtg act gat gac aaa gac cgg cgt ctc     1970
 Glu Cys Asn Tyr Gly Gly Arg Val Thr Asp Asp Lys Asp Arg Arg Leu
             640                 645                 650

 ctg ctg tca ctt ctg tcc atg ttc tac tgt aag gaa att gag gag gac     2018
 Leu Leu Ser Leu Leu Ser Met Phe Tyr Cys Lys Glu Ile Glu Glu Asp
         655                 660                 665

 tat tac tcc ctc gct cct gga gac act tac tac atc cct cct cat ggc     2066
 Tyr Tyr Ser Leu Ala Pro Gly Asp Thr Tyr Tyr Ile Pro Pro His Gly
     670                 675                 680

 tcc tac cag tcc tat atc gac tat ctc agg aat ctc ccc atc aca gcc     2114
 Ser Tyr Gln Ser Tyr Ile Asp Tyr Leu Arg Asn Leu Pro Ile Thr Ala
 685                 690                 695                 700

 cac cca gaa gtg ttc ggc ctc cat gag aac gca gac atc acc aaa gac     2162
 His Pro Glu Val Phe Gly Leu His Glu Asn Ala Asp Ile Thr Lys Asp
                 705                 710                 715

 aac cag gaa acc aac cag ctg ttt gag ggg gtc ctg ctg acc ctc cct     2210
 Asn Gln Glu Thr Asn Gln Leu Phe Glu Gly Val Leu Leu Thr Leu Pro
             720                 725                 730

 aga cag tca gga gga agt ggc aag tcc cct cag gaa gtg gtt gag gag     2258
 Arg Gln Ser Gly Gly Ser Gly Lys Ser Pro Gln Glu Val Val Glu Glu
         735                 740                 745

 ttg gca caa gac att ctc tcc aag ctt ccc aga gac ttt gac ctg gaa     2306
 Leu Ala Gln Asp Ile Leu Ser Lys Leu Pro Arg Asp Phe Asp Leu Glu
     750                 755                 760

 gag gtc atg aag ttg tac ccc gtg gtc tat gaa gaa tcc atg aat acc     2354
 Glu Val Met Lys Leu Tyr Pro Val Val Tyr Glu Glu Ser Met Asn Thr
 765                 770                 775                 780

 gtc cta agg cag gag ctc atc aga ttc aac agg ctg acc aaa gtg gtt     2402
 Val Leu Arg Gln Glu Leu Ile Arg Phe Asn Arg Leu Thr Lys Val Val
                 785                 790                 795

 cgg agg agc ctc atc aat ctt ggc cga gcc atc aaa gga cag gtc ctg     2450
 Arg Arg Ser Leu Ile Asn Leu Gly Arg Ala Ile Lys Gly Gln Val Leu
             800                 805                 810

 atg tcc tcg gag cta gag gaa gtc ttt aac agc atg ctt gtg ggt aaa     2498
 Met Ser Ser Glu Leu Glu Glu Val Phe Asn Ser Met Leu Val Gly Lys
         815                 820                 825

 gtg cca gcc atg tgg gca gcc aag tct tac cca tca ctg aag cct ctg     2546
 Val Pro Ala Met Trp Ala Ala Lys Ser Tyr Pro Ser Leu Lys Pro Leu
     830                 835                 840

 ggg ggc tac gtg gct gac ctg ctg gcc cgc ctg acc ttc ttc cag gaa     2594
 Gly Gly Tyr Val Ala Asp Leu Leu Ala Arg Leu Thr Phe Phe Gln Glu
 845                 850                 855                 860

 tgg att gac aag ggg ccc cct gtg gta ttt tgg atc tct gga ttc tac     2642
 Trp Ile Asp Lys Gly Pro Pro Val Val Phe Trp Ile Ser Gly Phe Tyr
                 865                 870                 875

 ttc aca cag tct ttt ttg act ggc gtc tct caa aat tat gcc cgg aaa     2690
 Phe Thr Gln Ser Phe Leu Thr Gly Val Ser Gln Asn Tyr Ala Arg Lys
             880                 885                 890

 tat acc atc ccc att gac cac att gga ttt gag ttt gag gta acc cca     2738
 Tyr Thr Ile Pro Ile Asp His Ile Gly Phe Glu Phe Glu Val Thr Pro
         895                 900                 905

 caa gaa aca gtg atg gag aat aac ccc gaa gat ggg gcc tac atc aaa     2786
 Gln Glu Thr Val Met Glu Asn Asn Pro Glu Asp Gly Ala Tyr Ile Lys
     910                 915                 920

 ggg ctc ttc tta gaa ggt gcc cgt tgg gac agg aaa acg atg cag att     2834
 Gly Leu Phe Leu Glu Gly Ala Arg Trp Asp Arg Lys Thr Met Gln Ile
 925                 930                 935                 940

 ggg gaa tct ctc ccc aaa atc ctc tat gac cca ctg ccc atc att tgg     2882
 Gly Glu Ser Leu Pro Lys Ile Leu Tyr Asp Pro Leu Pro Ile Ile Trp
                 945                 950                 955

 ctg aaa cct ggg gag agc gca atg ttt ctg cat cag gac atc tat gtg     2930
 Leu Lys Pro Gly Glu Ser Ala Met Phe Leu His Gln Asp Ile Tyr Val
             960                 965                 970

 tgt cca gtc tac aaa aca agt gcc cgc aga gga acc ctc tcc acc aca     2978
 Cys Pro Val Tyr Lys Thr Ser Ala Arg Arg Gly Thr Leu Ser Thr Thr
         975                 980                 985

 ggc cac tct acc aac tat gtc ctc tcc att gag ctt cca aca gac atg     3026
 Gly His Ser Thr Asn Tyr Val Leu Ser Ile Glu Leu Pro Thr Asp Met
     990                 995                1000

 ccc cag aag cac tgg ata aac cga ggg gtg gcc tca ctg tgc cag ctg     3074
 Pro Gln Lys His Trp Ile Asn Arg Gly Val Ala Ser Leu Cys Gln Leu
1005                1010                1015                1020

 gat aac tga tggcatt tgtctcaaga cagaaaataa aaagcatttc attcttaaaa     3130
 Asp Asn 






      <210> 421
      <211> 1594
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (115)..(1224)

      <400> 421
 gcttgcaaag tatggcaaag gcttggcaaa gactataagc ttttggaaaa cagggactat     60

 gtcttcttca acaatgtgta cacaacaagt agcaggttgt ttggcacatg gcag  atg     117
                                                              Met
                                                                1

 ctc ggc agt aca tgc cac act act acc ctt cct gct ctt gtg cgc aca      165
 Leu Gly Ser Thr Cys His Thr Thr Thr Leu Pro Ala Leu Val Arg Thr
               5                  10                  15

 cct acc ctg atg atg cag cct tca ctg gat atc aaa cca ttt atg tct      213
 Pro Thr Leu Met Met Gln Pro Ser Leu Asp Ile Lys Pro Phe Met Ser
          20                  25                  30

 ttt cca gtg gac agt agt tct gct gtt ggg ctc ttt cca aat ttt aac      261
 Phe Pro Val Asp Ser Ser Ser Ala Val Gly Leu Phe Pro Asn Phe Asn
      35                  40                  45

 aca atg gat cct gtg caa aaa gcg gtt att aac cat aca ttt gga gta      309
 Thr Met Asp Pro Val Gln Lys Ala Val Ile Asn His Thr Phe Gly Val
  50                  55                  60                  65

 tcc att ccc cca aag aag aaa caa gtt att tct tgt aat gtc tgt cag      357
 Ser Ile Pro Pro Lys Lys Lys Gln Val Ile Ser Cys Asn Val Cys Gln
                  70                  75                  80

 ctt cgc ttt aac tca gat agc cag gcc gag gcc cac tac aaa gga agt      405
 Leu Arg Phe Asn Ser Asp Ser Gln Ala Glu Ala His Tyr Lys Gly Ser
              85                  90                  95

 aaa cat gcc aag aag gtc aaa gca cta gac gca acg aaa aat aaa ccc      453
 Lys His Ala Lys Lys Val Lys Ala Leu Asp Ala Thr Lys Asn Lys Pro
         100                 105                 110

 aaa atg gtt cct tcc aag gac agc gca aag gct aat ccc agc tgc tcc      501
 Lys Met Val Pro Ser Lys Asp Ser Ala Lys Ala Asn Pro Ser Cys Ser
     115                 120                 125

 atc act cca atc aca ggc aac aac tct gac aaa tca gaa gat aaa ggg      549
 Ile Thr Pro Ile Thr Gly Asn Asn Ser Asp Lys Ser Glu Asp Lys Gly
 130                 135                 140                 145

 aag tta aaa gcc agc agt tcc agt cag cca tca agc tct gaa agt ggc      597
 Lys Leu Lys Ala Ser Ser Ser Ser Gln Pro Ser Ser Ser Glu Ser Gly
                 150                 155                 160

 tca ttt ctc ctc aaa tct ggc aca aca ccc ctg cca cct gga gca gcc      645
 Ser Phe Leu Leu Lys Ser Gly Thr Thr Pro Leu Pro Pro Gly Ala Ala
             165                 170                 175

 act tct ccc tcc aag agc aca aat gga gct ccc ggt act gtt gtt gaa      693
 Thr Ser Pro Ser Lys Ser Thr Asn Gly Ala Pro Gly Thr Val Val Glu
         180                 185                 190

 tca gaa gaa gaa aaa gcc aaa aaa tta ctt tat tgt tca cta tgc aaa      741
 Ser Glu Glu Glu Lys Ala Lys Lys Leu Leu Tyr Cys Ser Leu Cys Lys
     195                 200                 205

 gtg gct gtg aac tcc ctg tca cag cta gag gca cac aac aca gga tct      789
 Val Ala Val Asn Ser Leu Ser Gln Leu Glu Ala His Asn Thr Gly Ser
 210                 215                 220                 225

 aaa cac aag acc atg gtt gaa gct cgt aat ggg gct ggt cca att aaa      837
 Lys His Lys Thr Met Val Glu Ala Arg Asn Gly Ala Gly Pro Ile Lys
                 230                 235                 240

 tcc tat cct aga cct gga tca aga tta aag atg cag aat ggc agt aag      885
 Ser Tyr Pro Arg Pro Gly Ser Arg Leu Lys Met Gln Asn Gly Ser Lys
             245                 250                 255

 ggg tca gga cta cag aac aag aca ttt cat tgt gaa atc tgt gat gtt      933
 Gly Ser Gly Leu Gln Asn Lys Thr Phe His Cys Glu Ile Cys Asp Val
         260                 265                 270

 cat gtt aat tca gaa att caa ctc aaa cag cac att tct agc cga agg      981
 His Val Asn Ser Glu Ile Gln Leu Lys Gln His Ile Ser Ser Arg Arg
     275                 280                 285

 cat aaa gat cga gtt gca ggg aaa cca ctg aag cca aaa tac agc cct     1029
 His Lys Asp Arg Val Ala Gly Lys Pro Leu Lys Pro Lys Tyr Ser Pro
 290                 295                 300                 305

 tac aac aaa ctc cag cgg agc ccg agt att cta gca gca aaa ctt gca     1077
 Tyr Asn Lys Leu Gln Arg Ser Pro Ser Ile Leu Ala Ala Lys Leu Ala
                 310                 315                 320

 ttc cag aaa gat atg atg aag cct ttg gcc cag cct tcc tgt cct cac     1125
 Phe Gln Lys Asp Met Met Lys Pro Leu Ala Gln Pro Ser Cys Pro His
             325                 330                 335

 ctc tcg cag cgg cgg cat ccg tgt cct cag cgc tgt cac tcc cac ccc     1173
 Leu Ser Gln Arg Arg His Pro Cys Pro Gln Arg Cys His Ser His Pro
         340                 345                 350

 ggc cct ctg cct cgc tct tcc agg ctc cag cca ttc ctc cag ctc ttc     1221
 Gly Pro Leu Pro Arg Ser Ser Arg Leu Gln Pro Phe Leu Gln Leu Phe
     355                 360                 365

 tga ggcc tgggcatggg cccatccgcg ccactcctgc ctccatcctc tttgctccgt     1278
 


 actaacgtct gcaaacccca agacgtttga ggccagtagg aagttgagaa agaaagccac   1338

 aaggattcag caatttaagc agtttgtgtt gcagtacccc ccattcaccc acaaaatgca   1398

 gcccaccacc cagtccccca attccagaga gaaacacatc actagattga cgagggcttt   1458

 tagagactgc tcctataatt gaggaatcag cagcataggc tttatctccc tacttcctcc   1518

 cccaccctac cgcgttcaat ttgtgtatct cagatatttg atttcttgag catgtattgg   1578

 tcagaaaaaa aaaaaa                                                   1594




      <210> 422
      <211> 1143
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (178)..(1143)

      <400> 422
 atgaatccct gcggttggct gggggcagtg ggtcccacac tgcctaactt ccctaaatgg     60

 gcagcttcac ttttagaacc ccgggtcctt ccctggcagg cccaggtggc acatcctgtg    120

 tcgggtgggc cctcaccttg gatctccagg cctgacactg cccagctgga tggaacc       177                                                                 
 atg gcc cca gcc ttc ctg ctg ctg ctg ctg ctg tgg cca cag ggt tgc      225
 Met Ala Pro Ala Phe Leu Leu Leu Leu Leu Leu Trp Pro Gln Gly Cys
   1               5                  10                  15

 gtc tca ggc ccc tct gct gac agt gta tac aca aaa gtg agg ctc ctt      273
 Val Ser Gly Pro Ser Ala Asp Ser Val Tyr Thr Lys Val Arg Leu Leu
              20                  25                  30

 gaa ggg gag act ctg tct gtg cag tgc tcc tat aag ggc tac aaa aac      321
 Glu Gly Glu Thr Leu Ser Val Gln Cys Ser Tyr Lys Gly Tyr Lys Asn
          35                  40                  45

 cgc gtg gag ggc aag gtt tgg tgc aaa atc agg aag aag aag tgt gag      369
 Arg Val Glu Gly Lys Val Trp Cys Lys Ile Arg Lys Lys Lys Cys Glu
      50                  55                  60

 cct ggc ttt gcc cga gtc tgg gtg aaa ggg ccc cgc tac ttg ctg cag      417
 Pro Gly Phe Ala Arg Val Trp Val Lys Gly Pro Arg Tyr Leu Leu Gln
  65                  70                  75                  80

 gac gat gcc cag gcc aag gtg gtc aac atc acc atg gtg gcc ctc aag      465
 Asp Asp Ala Gln Ala Lys Val Val Asn Ile Thr Met Val Ala Leu Lys
                  85                  90                  95

 ctc cag gac tca ggc cga tac tgg tgc atg cgc aac acc tct ggg atc      513
 Leu Gln Asp Ser Gly Arg Tyr Trp Cys Met Arg Asn Thr Ser Gly Ile
             100                 105                 110

 ctg tac ccc ttg atg ggc ttc cag ctg gat gtg tct cca gct ccc caa      561
 Leu Tyr Pro Leu Met Gly Phe Gln Leu Asp Val Ser Pro Ala Pro Gln
         115                 120                 125

 act gag agg aac att cct ttc aca cat ctg gac aac atc ctc aag ggt      609
 Thr Glu Arg Asn Ile Pro Phe Thr His Leu Asp Asn Ile Leu Lys Gly
     130                 135                 140

 gga act gtc aca act ggc caa gcc cct acc tca ggc cct gat gcc cct      657
 Gly Thr Val Thr Thr Gly Gln Ala Pro Thr Ser Gly Pro Asp Ala Pro
 145                 150                 155                 160

 ttt acc act ggt gtg atg gtg ttc acc cca gga ctc atc acc ttg cct      705
 Phe Thr Thr Gly Val Met Val Phe Thr Pro Gly Leu Ile Thr Leu Pro
                 165                 170                 175

 agg ctc tta gcc tcc acc aga cct gcc tcc aag aca ggc tac agc ttc      753
 Arg Leu Leu Ala Ser Thr Arg Pro Ala Ser Lys Thr Gly Tyr Ser Phe
             180                 185                 190

 act gct acc agc acc acc agc cag gga ccc agg agg acc atg ggg tcc      801
 Thr Ala Thr Ser Thr Thr Ser Gln Gly Pro Arg Arg Thr Met Gly Ser
         195                 200                 205

 cag aca gtg acc gcg tct ccc agc aat gcc agg gac tcc tct gct ggc      849
 Gln Thr Val Thr Ala Ser Pro Ser Asn Ala Arg Asp Ser Ser Ala Gly
     210                 215                 220

 cca gaa tcc atc tcc act aag tct ggg gac ctc agc acc aga tcg ccc      897
 Pro Glu Ser Ile Ser Thr Lys Ser Gly Asp Leu Ser Thr Arg Ser Pro
 225                 230                 235                 240

 acc aca ggg ctc tgc ctc acc agc aga tct ctc ctc aac aga cta ccc      945
 Thr Thr Gly Leu Cys Leu Thr Ser Arg Ser Leu Leu Asn Arg Leu Pro
                 245                 250                 255

 tcc atg ccc tcc atc agg cac cag gat gtt tac tcc act gtg ctt ggg      993
 Ser Met Pro Ser Ile Arg His Gln Asp Val Tyr Ser Thr Val Leu Gly
             260                 265                 270

 gtg gtg ctg acc ctc ctg gtg ctg atg ctg atc atg gtc tat ggg ttt     1041
 Val Val Leu Thr Leu Leu Val Leu Met Leu Ile Met Val Tyr Gly Phe
         275                 280                 285

 tgg aag aag aga cac atg gca agc tac agc atg tgc agc gat cct tct     1089
 Trp Lys Lys Arg His Met Ala Ser Tyr Ser Met Cys Ser Asp Pro Ser
     290                 295                 300

 aca cgt gac cca cct gga aga cca gag ccc tat gtg gaa gtc tac ttg     1137
 Thr Arg Asp Pro Pro Gly Arg Pro Glu Pro Tyr Val Glu Val Tyr Leu
 305                 310                 315                 320

 atc tga                                                             1143
 Ile 






      <210> 423
      <211> 2768
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (72)..(2738)

      <400> 423
 agcccaaggg ggtgtttgcg aaggagcagt cagtgcataa tgaggtgcag gctgaggcgg     60

 ggaccactgc c atg ctg agc tgt gag gtg ggc cag ccc cag acg gag atg     110
              Met Leu Ser Cys Glu Val Gly Gln Pro Gln Thr Glu Met
                1               5                  10

 gcg acc gcg gcg ctg ctt cga ggc gcc act ccg ggg cgc ggc ggc ccg      158
 Ala Thr Ala Ala Leu Leu Arg Gly Ala Thr Pro Gly Arg Gly Gly Pro
      15                  20                  25

 gtc tgg cgc tgg cgg ctg cgc gcg gcc cca agg tgc cgc ctg gcc cac      206
 Val Trp Arg Trp Arg Leu Arg Ala Ala Pro Arg Cys Arg Leu Ala His
  30                  35                  40                  45

 agc tcc tgc agt cct ggt ggc gac cca acg gcc gga gcg gcc tgg gcc      254
 Ser Ser Cys Ser Pro Gly Gly Asp Pro Thr Ala Gly Ala Ala Trp Ala
                  50                  55                  60

 tgc ttc cgg ctg gac ggg cgc acc ctg ctg cgc gtg cgt ggc ccc gac      302
 Cys Phe Arg Leu Asp Gly Arg Thr Leu Leu Arg Val Arg Gly Pro Asp
              65                  70                  75

 gcg gcg ccc ttc ctg cta ggg ctg ctg acc aat gaa ctg ccg ctt ccg      350
 Ala Ala Pro Phe Leu Leu Gly Leu Leu Thr Asn Glu Leu Pro Leu Pro
          80                  85                  90

 agt cct gcg gcc gcg ggg gcc ccg cct gct gcg cgc gcg ggc tac gcc      398
 Ser Pro Ala Ala Ala Gly Ala Pro Pro Ala Ala Arg Ala Gly Tyr Ala
      95                 100                 105

 cac ttc ctg aac gtg cag ggc cgg acg ctc tat gac gtc atc ttg tac      446
 His Phe Leu Asn Val Gln Gly Arg Thr Leu Tyr Asp Val Ile Leu Tyr
 110                 115                 120                 125

 ggg ctc cag gaa cac tcg gag gtg tct ggc ttc ctt ctg gag tgt gac      494
 Gly Leu Gln Glu His Ser Glu Val Ser Gly Phe Leu Leu Glu Cys Asp
                 130                 135                 140

 agc tcg gtg cag ggc gcg ctg cag aag cac ctc gcg cta tac agg atc      542
 Ser Ser Val Gln Gly Ala Leu Gln Lys His Leu Ala Leu Tyr Arg Ile
             145                 150                 155

 cgg cgg aag gtc acg gtg gag ccg cac ccg gag ctg cga gtg tgg gcg      590
 Arg Arg Lys Val Thr Val Glu Pro His Pro Glu Leu Arg Val Trp Ala
         160                 165                 170

 gtg ttg ccc agt tcc cct gag gcc tgc ggg gct gca tcg ctg cag gag      638
 Val Leu Pro Ser Ser Pro Glu Ala Cys Gly Ala Ala Ser Leu Gln Glu
     175                 180                 185

 agg gca ggg gct gcc gcc atc ctc atc cgc gac ccg cga aca gca cgc      686
 Arg Ala Gly Ala Ala Ala Ile Leu Ile Arg Asp Pro Arg Thr Ala Arg
 190                 195                 200                 205

 atg ggg tgg cgg ctc ctc acc cag gat gaa ggc cca gcc ctg gtg ccc      734
 Met Gly Trp Arg Leu Leu Thr Gln Asp Glu Gly Pro Ala Leu Val Pro
                 210                 215                 220

 ggg agc cgg ctc ggg gac ttg tgg gat tat cac cag cac cga tac ctg      782
 Gly Ser Arg Leu Gly Asp Leu Trp Asp Tyr His Gln His Arg Tyr Leu
             225                 230                 235

 caa ggc gtt cct gag ggg gtc cga gac ttg cct cct ggg gtg gcc ctg      830
 Gln Gly Val Pro Glu Gly Val Arg Asp Leu Pro Pro Gly Val Ala Leu
         240                 245                 250

 ccc ctg gag tcc aac ctg gcc ttc atg aac ggc gtg agc ttc acc aaa      878
 Pro Leu Glu Ser Asn Leu Ala Phe Met Asn Gly Val Ser Phe Thr Lys
     255                 260                 265

 ggc tgc tac att ggc cag gag ctg acg gcc cgc acc cac cac atg ggc      926
 Gly Cys Tyr Ile Gly Gln Glu Leu Thr Ala Arg Thr His His Met Gly
 270                 275                 280                 285

 gtc atc cgc aag cgc ctc ttc cct gtc cgg ttc ttg gac ccc ctt ccc      974
 Val Ile Arg Lys Arg Leu Phe Pro Val Arg Phe Leu Asp Pro Leu Pro
                 290                 295                 300

 acc agt ggc atc acc cct ggt gcc acg gtg ctg act gcc tca gga cag     1022
 Thr Ser Gly Ile Thr Pro Gly Ala Thr Val Leu Thr Ala Ser Gly Gln
             305                 310                 315

 act gtg ggc aag ttc agg gct ggc cag ggc aac gtg ggg ctg gcc ctg     1070
 Thr Val Gly Lys Phe Arg Ala Gly Gln Gly Asn Val Gly Leu Ala Leu
         320                 325                 330

 ctg tgg tca gag aag atc aag ggt cct ctg cac atc aga gcc tct gag     1118
 Leu Trp Ser Glu Lys Ile Lys Gly Pro Leu His Ile Arg Ala Ser Glu
     335                 340                 345

 gga aac ctc ctc cga aag ctc cct cgg aag acg gcg gtg cgc gtg ggc     1166
 Gly Asn Leu Leu Arg Lys Leu Pro Arg Lys Thr Ala Val Arg Val Gly
 350                 355                 360                 365

 gac acg gct atg ttt tgc gtg gag ctg gcg gtc ccg gtg ggc ccc gtc     1214
 Asp Thr Ala Met Phe Cys Val Glu Leu Ala Val Pro Val Gly Pro Val
                 370                 375                 380

 cac tgg ctg cgg aac cag gag gaa gtg gtg gcg ggg ggc cgc gtg gcc     1262
 His Trp Leu Arg Asn Gln Glu Glu Val Val Ala Gly Gly Arg Val Ala
             385                 390                 395

 atc tcc gcg gag ggc acg cgc cac aca cta acc atc tcc cag tgc tgc     1310
 Ile Ser Ala Glu Gly Thr Arg His Thr Leu Thr Ile Ser Gln Cys Cys
         400                 405                 410

 ctg gag gat gtg ggc cag gtg gcc ttt atg gct ggc gac tgc cag acg     1358
 Leu Glu Asp Val Gly Gln Val Ala Phe Met Ala Gly Asp Cys Gln Thr
     415                 420                 425

 tcc acc cag ttc tgc gtg tcg gcc ccc agg aag cct ccc ttg caa ccc     1406
 Ser Thr Gln Phe Cys Val Ser Ala Pro Arg Lys Pro Pro Leu Gln Pro
 430                 435                 440                 445

 cct gtg gat cct gtg gta aag gcc agg atg gag agt tcc gtg att ctc     1454
 Pro Val Asp Pro Val Val Lys Ala Arg Met Glu Ser Ser Val Ile Leu
                 450                 455                 460

 agc tgg tcc cca cca ccc cat ggg gaa cgc cct gtc act atc gac ggc     1502
 Ser Trp Ser Pro Pro Pro His Gly Glu Arg Pro Val Thr Ile Asp Gly
             465                 470                 475

 tac ctg gta gag aag aag aag ctt ggc acc tac acc tgg atc agg tgc     1550
 Tyr Leu Val Glu Lys Lys Lys Leu Gly Thr Tyr Thr Trp Ile Arg Cys
         480                 485                 490

 cac gag gct gaa tgg gtg gct aca cct gag ctg acc gtg gct gat gtg     1598
 His Glu Ala Glu Trp Val Ala Thr Pro Glu Leu Thr Val Ala Asp Val
     495                 500                 505

 gcg gag gag ggg aac ttc cag ttc cga gtg tcc gct ctc aac agc ttt     1646
 Ala Glu Glu Gly Asn Phe Gln Phe Arg Val Ser Ala Leu Asn Ser Phe
 510                 515                 520                 525

 ggt cag agt ccc tac ctc gag ttc ccg ggg act gtc cac ctg gcc ccc     1694
 Gly Gln Ser Pro Tyr Leu Glu Phe Pro Gly Thr Val His Leu Ala Pro
                 530                 535                 540

 aag ctg gcc gtg agg aca ccg ctg aag gcg gtg cag gcg gta gag ggt     1742
 Lys Leu Ala Val Arg Thr Pro Leu Lys Ala Val Gln Ala Val Glu Gly
             545                 550                 555

 ggc gag gtc act ttc tcc gtg gac ctc acg gtg gcc tca gcg ggt gag     1790
 Gly Glu Val Thr Phe Ser Val Asp Leu Thr Val Ala Ser Ala Gly Glu
         560                 565                 570

 tgg ttc ctg gat ggg cag gcc ctg aag gcc agc agt gtg tat gag atc     1838
 Trp Phe Leu Asp Gly Gln Ala Leu Lys Ala Ser Ser Val Tyr Glu Ile
     575                 580                 585

 cac tgt gat cgc acc cgg cac acg ctc acc atc cgg gag gtg ccc gcc     1886
 His Cys Asp Arg Thr Arg His Thr Leu Thr Ile Arg Glu Val Pro Ala
 590                 595                 600                 605

 agc ctg cac ggg gcg cag ctg aag ttc gtg gcc aac ggc att gag agc     1934
 Ser Leu His Gly Ala Gln Leu Lys Phe Val Ala Asn Gly Ile Glu Ser
                 610                 615                 620

 agc atc cgg atg gag gtc cgg gcg gcc cca ggg ctg act gcc aac aag     1982
 Ser Ile Arg Met Glu Val Arg Ala Ala Pro Gly Leu Thr Ala Asn Lys
             625                 630                 635

 ccg cca gcc gca gct gcc cgg gag gtg ctg gct cgg ctg cac gag gag     2030
 Pro Pro Ala Ala Ala Ala Arg Glu Val Leu Ala Arg Leu His Glu Glu
         640                 645                 650

 gcg cag ctg ctg gct gag ctg tca gat cag gct gcg gct gtg acg tgg     2078
 Ala Gln Leu Leu Ala Glu Leu Ser Asp Gln Ala Ala Ala Val Thr Trp
     655                 660                 665

 ctg aag gat ggt cgc aca ctg tcc cca ggc ccc aag tat gag gtg cag     2126
 Leu Lys Asp Gly Arg Thr Leu Ser Pro Gly Pro Lys Tyr Glu Val Gln
 670                 675                 680                 685

 gca tcg gcc ggg cgg cgg gtg ctc ctt gtg cga gat gtg gcc cgg gac     2174
 Ala Ser Ala Gly Arg Arg Val Leu Leu Val Arg Asp Val Ala Arg Asp
                 690                 695                 700

 gat gca ggc ctc tac gag tgc gtc agc cgc ggg ggc cgc atc gcc tac     2222
 Asp Ala Gly Leu Tyr Glu Cys Val Ser Arg Gly Gly Arg Ile Ala Tyr
             705                 710                 715

 cag ctc tcc gtg caa ggc ctc gcg cgc ttt ctg cac aag gac atg gcg     2270
 Gln Leu Ser Val Gln Gly Leu Ala Arg Phe Leu His Lys Asp Met Ala
         720                 725                 730

 ggc agc tgt gtg gat gcc gtg gct ggg ggc ccg gcg cag ttt gag tgt     2318
 Gly Ser Cys Val Asp Ala Val Ala Gly Gly Pro Ala Gln Phe Glu Cys
     735                 740                 745

 gag acc tcc gaa gcc cac gtc cac gtg cac tgg tac aag gat ggc atg     2366
 Glu Thr Ser Glu Ala His Val His Val His Trp Tyr Lys Asp Gly Met
 750                 755                 760                 765

 gag ctg ggc cac tcc ggt gag cgc ttc ttg cag gag gat gtg ggg acg     2414
 Glu Leu Gly His Ser Gly Glu Arg Phe Leu Gln Glu Asp Val Gly Thr
                 770                 775                 780

 cgg cac cgg ctg gtg gca gcc aca gtc acc agg cag gat gaa ggc acc     2462
 Arg His Arg Leu Val Ala Ala Thr Val Thr Arg Gln Asp Glu Gly Thr
             785                 790                 795

 tac tcc tgc cgc gtg ggc gag gac tct gtg gac ttc cgg ctc cgc gtc     2510
 Tyr Ser Cys Arg Val Gly Glu Asp Ser Val Asp Phe Arg Leu Arg Val
         800                 805                 810

 tct gag ccc aag gcg gtg ttt gcc aag gag cag ccg gcg tgc agg gag     2558
 Ser Glu Pro Lys Ala Val Phe Ala Lys Glu Gln Pro Ala Cys Arg Glu
     815                 820                 825

 gtg cag gct gag gtg ggg gcc agc gcc acg ctg agc tgt gag gtg gcc     2606
 Val Gln Ala Glu Val Gly Ala Ser Ala Thr Leu Ser Cys Glu Val Ala
 830                 835                 840                 845

 cag gac cag atg gag gtg acg tgg tac aag gac ggg aag aag ttg agc     2654
 Gln Asp Gln Met Glu Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Ser
                 850                 855                 860

 tcc agc tcg aaa gtg cac gtg gag gct gtg ggc tgt atg cgg agg ctg     2702
 Ser Ser Ser Lys Val His Val Glu Ala Val Gly Cys Met Arg Arg Leu
             865                 870                 875

 gtg gtg cag cag gtg ggc cag gca gac tcc gga tag taca gctgtgaagc     2752
 Val Val Gln Gln Val Gly Gln Ala Asp Ser Gly 
         880                 885

 caggtggtta caaaaa                                                   2768




      <210> 424
      <211> 806
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (51)..(806)

      <400> 424
 cactcactca ctcacacacc tcccccagct caccgcctcc ccactccagc   atg gcc      56
                                                          Met Ala
                                                            1

 gcc tcc acc atg tcc atc tgc tcc agc gcc tgc act gac tct tgg cgg      104
 Ala Ser Thr Met Ser Ile Cys Ser Ser Ala Cys Thr Asp Ser Trp Arg
           5                  10                  15

 gta gac gac tgc cca gag agc tgc tgc gag ccc tgc tgc tgt gcc cca      152
 Val Asp Asp Cys Pro Glu Ser Cys Cys Glu Pro Cys Cys Cys Ala Pro
      20                  25                  30

 gcc ccc agc ttg acc ctg gtc tgc acc cca gtg agc tgt gtg tcc agc      200
 Ala Pro Ser Leu Thr Leu Val Cys Thr Pro Val Ser Cys Val Ser Ser
  35                  40                  45                  50

 ccc tgc tgc cag acg gcc tgt gag ccc agc gcc tgc caa tca ggc tac      248
 Pro Cys Cys Gln Thr Ala Cys Glu Pro Ser Ala Cys Gln Ser Gly Tyr
                  55                  60                  65

 acc agc tcc tgc aca ccc cca tgc tac cag cag tct agc tgc cag ccg      296
 Thr Ser Ser Cys Thr Pro Pro Cys Tyr Gln Gln Ser Ser Cys Gln Pro
              70                  75                  80

 gat tgc tgc acc tcc tcc ccc tgc cag cag gcc tgc tgt gtg cct gtc      344
 Asp Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys Cys Val Pro Val
          85                  90                  95

 tgc tgt gtg ccc gtc tgc tgc gtg ccc gtc tgt aac aag cct gtg tgc      392
 Cys Cys Val Pro Val Cys Cys Val Pro Val Cys Asn Lys Pro Val Cys
     100                 105                 110

 ttc gtg cct acc tgc tcc gag tct tcc cct tca tgc tgc cag cag tct      440
 Phe Val Pro Thr Cys Ser Glu Ser Ser Pro Ser Cys Cys Gln Gln Ser
 115                 120                 125                 130

 agc tgc cag cca act tgc tgc acc tcc tcc cca tgc cag cag gcc tgc      488
 Ser Cys Gln Pro Thr Cys Cys Thr Ser Ser Pro Cys Gln Gln Ala Cys
                 135                 140                 145

 tgt gtg cct gtc tgc tct aag tcc gtc tgc tat gtg cct gtg tgc tct      536
 Cys Val Pro Val Cys Ser Lys Ser Val Cys Tyr Val Pro Val Cys Ser
             150                 155                 160

 ggg gct tcc act tca tgc tgc cag cag tct agc tgc cag cct gct tgc      584
 Gly Ala Ser Thr Ser Cys Cys Gln Gln Ser Ser Cys Gln Pro Ala Cys
         165                 170                 175

 tgc acc gcc tcc tgc tgc aga ccc tcc tcc tcc gtg tcc ctc ctc tgc      632
 Cys Thr Ala Ser Cys Cys Arg Pro Ser Ser Ser Val Ser Leu Leu Cys
     180                 185                 190

 cac cct gtg tgc aag tcc acc tgc tgc gtg ccc gtc ccc tcc tgc ggt      680
 His Pro Val Cys Lys Ser Thr Cys Cys Val Pro Val Pro Ser Cys Gly
 195                 200                 205                 210

 gcc tct gcc tcc tcc tgc cag ccc agc tgc tgc cgc acg gcc tcc tgt      728
 Ala Ser Ala Ser Ser Cys Gln Pro Ser Cys Cys Arg Thr Ala Ser Cys
                 215                 220                 225

 gtt tcc ctc ctc tgc cgc ccc gtg tgc tcc cgc cct gcc tgc tac agc      776
 Val Ser Leu Leu Cys Arg Pro Val Cys Ser Arg Pro Ala Cys Tyr Ser
             230                 235                 240

 ctc tgc tct ggc cag aag tcc agc tgc tga                              806
 Leu Cys Ser Gly Gln Lys Ser Ser Cys 
         245                 250





      <210> 425
      <211> 1551
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (171)..(1376)

      <400> 425
 gcgtgaagct tgctggctct tctttttcct atcgctccat gacaagctaa cagagagagc     60

 ggagagtcac aatccaaggt ccggctcctc cgcgtcccag ggccggacgg agggatgagg    120

 cagggggggc ccgggcagcg ccgttgctgc tccccccgcc gcccgcagcc   atg gaa     176
                                                          Met Glu
                                                            1

 acg ggg aag gac ggc gcc cgc aga ggt aca caa agc ccg gag cgg aaa      224
 Thr Gly Lys Asp Gly Ala Arg Arg Gly Thr Gln Ser Pro Glu Arg Lys
           5                  10                  15

 agg cga agc cca gtg ccg cgg gcg ccc agc acg aag ctg agg ccg gcg      272
 Arg Arg Ser Pro Val Pro Arg Ala Pro Ser Thr Lys Leu Arg Pro Ala
      20                  25                  30

 gcg gcg gcc cgg gcc atg gat ccg gtg gcg gcc gag gcc ccg ggc gag      320
 Ala Ala Ala Arg Ala Met Asp Pro Val Ala Ala Glu Ala Pro Gly Glu
  35                  40                  45                  50

 gcc ttc ctg gcg cgg cga cgg cct gag ggc ggt ggc ggg tcc gcg cgg      368
 Ala Phe Leu Ala Arg Arg Arg Pro Glu Gly Gly Gly Gly Ser Ala Arg
                  55                  60                  65

 ccg cgt tac agc ctg ttg gcg gag atc ggg cgc ggc agc tac ggc gtg      416
 Pro Arg Tyr Ser Leu Leu Ala Glu Ile Gly Arg Gly Ser Tyr Gly Val
              70                  75                  80

 gtt tat gag gca gtg gcc ggg cgc agc ggg gcc cgg gtg gcg gtc aag      464
 Val Tyr Glu Ala Val Ala Gly Arg Ser Gly Ala Arg Val Ala Val Lys
          85                  90                  95

 aag atc cgc tgc gac gcc ccc gag aac gtg gag ctg gcg ctg gct gaa      512
 Lys Ile Arg Cys Asp Ala Pro Glu Asn Val Glu Leu Ala Leu Ala Glu
     100                 105                 110

 ttc tgg gcc ctc acc agc ctc aag cgg cgc cac cag aac gtc gtg cag      560
 Phe Trp Ala Leu Thr Ser Leu Lys Arg Arg His Gln Asn Val Val Gln
 115                 120                 125                 130

 ttt gag gag tgc gtc ctg cag cgc aat ggg tta gcc cag cgc atg agt      608
 Phe Glu Glu Cys Val Leu Gln Arg Asn Gly Leu Ala Gln Arg Met Ser
                 135                 140                 145

 cac ggc aac aag agc tcg cag ctt tac ctg cgc ctg gtg gag acc tcg      656
 His Gly Asn Lys Ser Ser Gln Leu Tyr Leu Arg Leu Val Glu Thr Ser
             150                 155                 160

 ctg aaa gga gaa agg atc ctg ggt tat gct gag gag ccc tgc tat ctc      704
 Leu Lys Gly Glu Arg Ile Leu Gly Tyr Ala Glu Glu Pro Cys Tyr Leu
         165                 170                 175

 tgg ttt gtc atg gag ttc tgt gaa ggt gga gac ctg aat cag tat gtc      752
 Trp Phe Val Met Glu Phe Cys Glu Gly Gly Asp Leu Asn Gln Tyr Val
     180                 185                 190

 ctg tcc cgg agg cca gac cca gcc acc aac aaa agt ttc atg cta cag      800
 Leu Ser Arg Arg Pro Asp Pro Ala Thr Asn Lys Ser Phe Met Leu Gln
 195                 200                 205                 210

 ctg acg agc gcc att gcc ttc ctg cac aaa aac cat att gtg cac agg      848
 Leu Thr Ser Ala Ile Ala Phe Leu His Lys Asn His Ile Val His Arg
                 215                 220                 225

 gac ctg aag cca gac aac atc ctc atc aca gag cgg tct ggc acc ccc      896
 Asp Leu Lys Pro Asp Asn Ile Leu Ile Thr Glu Arg Ser Gly Thr Pro
             230                 235                 240

 atc ctc aaa gtg gcc gac ttt gga cta agc aag gtc tgt gct ggg ctg      944
 Ile Leu Lys Val Ala Asp Phe Gly Leu Ser Lys Val Cys Ala Gly Leu
         245                 250                 255

 gca ccc cga ggc aaa gag ggc aat caa gac aac aaa aat gtg aat gtg      992
 Ala Pro Arg Gly Lys Glu Gly Asn Gln Asp Asn Lys Asn Val Asn Val
     260                 265                 270

 aat aag tac tgg ctg tcc tca gcc tgc ggt tcg gac ttc tac atg gct     1040
 Asn Lys Tyr Trp Leu Ser Ser Ala Cys Gly Ser Asp Phe Tyr Met Ala
 275                 280                 285                 290

 cct gaa gtc tgg gag gga cac tac aca gcc aag gcg gac atc ttt gcc     1088
 Pro Glu Val Trp Glu Gly His Tyr Thr Ala Lys Ala Asp Ile Phe Ala
                 295                 300                 305

 ctg ggc att atc atc tgg gca atg ata gaa aga atc act ttt att gac     1136
 Leu Gly Ile Ile Ile Trp Ala Met Ile Glu Arg Ile Thr Phe Ile Asp
             310                 315                 320

 tct gag acc aag aag gag ctc ctg ggg acc tac att aaa cag ggg act     1184
 Ser Glu Thr Lys Lys Glu Leu Leu Gly Thr Tyr Ile Lys Gln Gly Thr
         325                 330                 335

 gag atc gtc cct gtt ggt gag gcg ctg cta gaa aac cca aag atg gag     1232
 Glu Ile Val Pro Val Gly Glu Ala Leu Leu Glu Asn Pro Lys Met Glu
     340                 345                 350

 ttg cac atc ccc caa aaa cgc agg act tcc atg tct gag ggg atc aag     1280
 Leu His Ile Pro Gln Lys Arg Arg Thr Ser Met Ser Glu Gly Ile Lys
 355                 360                 365                 370

 cag ctc ttg aaa gat atg tta gct gct aac cca cag gac cgg cct gat     1328
 Gln Leu Leu Lys Asp Met Leu Ala Ala Asn Pro Gln Asp Arg Pro Asp
                 375                 380                 385

 gcc ttt gaa ctt gaa acc aga atg gac cag gtc aca tgt gct gct taa     1376
 Ala Phe Glu Leu Glu Thr Arg Met Asp Gln Val Thr Cys Ala Ala 
             390                 395                 400

 aattcagggc taagcatttt gggtgatttt aaactaggtc gattcctcgg gacccacagt   1436

 ctcaccacgt ctcctccaga ggacggcaga gggtacaggt ggtggcctgg ccggttggcg   1496

 atctcccgac agctggatcc ggcaatgtga agcttttgtt tgggtttccc cgctt        1551




      <210> 426
      <211> 690
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (66)..(656)

      <400> 426
 actcggctct tccccaggag gaccaagccc tgaatcaggt gcagtgctgc ctgccccact     60

 gtgcc    atg ggc cct ggg ctc ctc tgc tgg gtg ctg ctt tgt ctc ctg     107
          Met Gly Pro Gly Leu Leu Cys Trp Val Leu Leu Cys Leu Leu
            1               5                  10

 gga gca ggc tca gtg gag act gga gtc acc caa agt ccc aca cac ctg      155
 Gly Ala Gly Ser Val Glu Thr Gly Val Thr Gln Ser Pro Thr His Leu
  15                  20                  25                  30

 atc aaa acg aga gga cag caa gtg act ctg aga tgc tct tct cag tct      203
 Ile Lys Thr Arg Gly Gln Gln Val Thr Leu Arg Cys Ser Ser Gln Ser
                  35                  40                  45

 ggg cac aac act gtg tcc tgg tac caa cag gcc ctg ggt cag ggg ccc      251
 Gly His Asn Thr Val Ser Trp Tyr Gln Gln Ala Leu Gly Gln Gly Pro
              50                  55                  60

 cag ttt atc ttt cag tat tat agg gag gaa gag aat ggc aga gga aac      299
 Gln Phe Ile Phe Gln Tyr Tyr Arg Glu Glu Glu Asn Gly Arg Gly Asn
          65                  70                  75

 ttc cct cct aga ttc tca ggt ctc cag ttc cct aat tat agc tct gag      347
 Phe Pro Pro Arg Phe Ser Gly Leu Gln Phe Pro Asn Tyr Ser Ser Glu
      80                  85                  90

 ctg aat gtg aac gcc ttg gag ctg gac gac tcg gcc ctg tat ctc tgt      395
 Leu Asn Val Asn Ala Leu Glu Leu Asp Asp Ser Ala Leu Tyr Leu Cys
  95                 100                 105                 110

 gcc agc agc ttc cta gcg ggg ggg cac gat gat tca ggt aga gga ggt      443
 Ala Ser Ser Phe Leu Ala Gly Gly His Asp Asp Ser Gly Arg Gly Gly
                 115                 120                 125

 gct ttt aca aaa aac cct gat gca gta agc atc ccc acc cag ctc agg      491
 Ala Phe Thr Lys Asn Pro Asp Ala Val Ser Ile Pro Thr Gln Leu Arg
             130                 135                 140

 gaa tgc agc tac cag gtg gga aga gtt ctc tgg ggc tgg tcc cag ctg      539
 Glu Cys Ser Tyr Gln Val Gly Arg Val Leu Trp Gly Trp Ser Gln Leu
         145                 150                 155

 tgg tct tgc agg gtc ccc caa ccc agc gag cac ctg tcc atc tcc ctg      587
 Trp Ser Cys Arg Val Pro Gln Pro Ser Glu His Leu Ser Ile Ser Leu
     160                 165                 170

 tcc aga ctc ggc ttc caa gga ata aga agg cca aga cag caa agt ggg      635
 Ser Arg Leu Gly Phe Gln Gly Ile Arg Arg Pro Arg Gln Gln Ser Gly
 175                 180                 185                 190

 att atc act cag cac ttt taa ta aaacttgttc ttgacaaagt aaaaaaaaaa      688
 Ile Ile Thr Gln His Phe 
                 195

 aa                                                                   690




      <210> 427
      <211> 1464
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1464)

      <400> 427
  atg ccg aat ccc cac cct ctg tgc tgg gaa gca gtt cca gtg acc aat      48
  Met Pro Asn Pro His Pro Leu Cys Trp Glu Ala Val Pro Val Thr Asn
    1               5                  10                  15

 gag ctc agt gag ctt gca gat att tac tta tgg gat gcc tac tgt ttg       96
 Glu Leu Ser Glu Leu Ala Asp Ile Tyr Leu Trp Asp Ala Tyr Cys Leu
              20                  25                  30

 aaa aac aat gtg agg gca tac acg gat gaa tta gag cag ttt ttt ctt      144
 Lys Asn Asn Val Arg Ala Tyr Thr Asp Glu Leu Glu Gln Phe Phe Leu
          35                  40                  45

 gtg gaa cat aca cac tgg gac cag gaa gat gac ctg act gag gtg act      192
 Val Glu His Thr His Trp Asp Gln Glu Asp Asp Leu Thr Glu Val Thr
      50                  55                  60

 ttc tgc aga ctt cgg act cac cag tgg tgt ttc att cta ttt aat gtc      240
 Phe Cys Arg Leu Arg Thr His Gln Trp Cys Phe Ile Leu Phe Asn Val
  65                  70                  75                  80

 atc cta ttt cat gcc ttg ctt ttt ggg act gac ttt gtg gag gaa tac      288
 Ile Leu Phe His Ala Leu Leu Phe Gly Thr Asp Phe Val Glu Glu Tyr
                  85                  90                  95

 ttt ctg cat tct ttg cct tat ata gat gtg aaa gtt ctt gaa att aag      336
 Phe Leu His Ser Leu Pro Tyr Ile Asp Val Lys Val Leu Glu Ile Lys
             100                 105                 110

 aat aag gca aga aaa ttg aac atc gaa ccc cta aga agt aat ctc tcc      384
 Asn Lys Ala Arg Lys Leu Asn Ile Glu Pro Leu Arg Ser Asn Leu Ser
         115                 120                 125

 aaa tac tat gtc ctg agc cag tca gaa ata tgt aaa ggg aag aac att      432
 Lys Tyr Tyr Val Leu Ser Gln Ser Glu Ile Cys Lys Gly Lys Asn Ile
     130                 135                 140

 ttt ttg ctg tct ctt atc ttc agt agc cca gga aat gga aca aga cgg      480
 Phe Leu Leu Ser Leu Ile Phe Ser Ser Pro Gly Asn Gly Thr Arg Arg
 145                 150                 155                 160

 gac ctc att agg aaa act tgg ggc aat gtg acc agt gtc caa ggg cat      528
 Asp Leu Ile Arg Lys Thr Trp Gly Asn Val Thr Ser Val Gln Gly His
                 165                 170                 175

 ccc att ctc aca ctg ttt gct ctg gga atg cct gtt tcg gta act acc      576
 Pro Ile Leu Thr Leu Phe Ala Leu Gly Met Pro Val Ser Val Thr Thr
             180                 185                 190

 cag aaa gag atc aac aaa gaa tcc tgt aag aat aat gat ata att gaa      624
 Gln Lys Glu Ile Asn Lys Glu Ser Cys Lys Asn Asn Asp Ile Ile Glu
         195                 200                 205

 gga atc ttc ttg gac agt tct gag aac caa acc ctg aag atc att gca      672
 Gly Ile Phe Leu Asp Ser Ser Glu Asn Gln Thr Leu Lys Ile Ile Ala
     210                 215                 220

 atg ata cag tgg gct gtg gct ttc tgc cct aat gcc ctg ttc att ctc      720
 Met Ile Gln Trp Ala Val Ala Phe Cys Pro Asn Ala Leu Phe Ile Leu
 225                 230                 235                 240

 aag gtg gat gaa gag acg ttt gtc aat cta cca agc ttg gta gac tat      768
 Lys Val Asp Glu Glu Thr Phe Val Asn Leu Pro Ser Leu Val Asp Tyr
                 245                 250                 255

 ctt ctc aat ctg aaa gaa cac cta gaa gat atc tat gta gga aga gtt      816
 Leu Leu Asn Leu Lys Glu His Leu Glu Asp Ile Tyr Val Gly Arg Val
             260                 265                 270

 ctt cat cag gtt aca ccc aat aga gat cct cag aac aga gac ttt gtc      864
 Leu His Gln Val Thr Pro Asn Arg Asp Pro Gln Asn Arg Asp Phe Val
         275                 280                 285

 cct ctt agt gag tac cca gaa aaa tac tac cca gat tac tgc agt ggt      912
 Pro Leu Ser Glu Tyr Pro Glu Lys Tyr Tyr Pro Asp Tyr Cys Ser Gly
     290                 295                 300

 gag gcc ttt ata atg tcc caa gat gtg gct cga atg atg tat gtg gtt      960
 Glu Ala Phe Ile Met Ser Gln Asp Val Ala Arg Met Met Tyr Val Val
 305                 310                 315                 320

 ttc aaa gaa gta ccc atg atg gtg cca gct gat gtg ttt gta gga att     1008
 Phe Lys Glu Val Pro Met Met Val Pro Ala Asp Val Phe Val Gly Ile
                 325                 330                 335

 tgt gct aag ttc att ggc ctt ata ccc atc cac agc tca agg ttt tct     1056
 Cys Ala Lys Phe Ile Gly Leu Ile Pro Ile His Ser Ser Arg Phe Ser
             340                 345                 350

 ggg aaa agg cac att aga tac aac aga tgt tgc tat aag ttc att ttt     1104
 Gly Lys Arg His Ile Arg Tyr Asn Arg Cys Cys Tyr Lys Phe Ile Phe
         355                 360                 365

 aca tcc tca gaa att gca gat cct gaa atg ccc cta gca tgg aag gaa     1152
 Thr Ser Ser Glu Ile Ala Asp Pro Glu Met Pro Leu Ala Trp Lys Glu
     370                 375                 380

 att aat gat gga aaa gaa tgt aca ctg ttt gag aca tcc tat gag ctc     1200
 Ile Asn Asp Gly Lys Glu Cys Thr Leu Phe Glu Thr Ser Tyr Glu Leu
 385                 390                 395                 400

 att tcc tgc aaa ctt ctg acg att ttg aat ata cca ttc cat tcc ttt     1248
 Ile Ser Cys Lys Leu Leu Thr Ile Leu Asn Ile Pro Phe His Ser Phe
                 405                 410                 415

 ctt gac tgc aag gtt tct gaa gat aaa tct gct gat agt ctt ata tat     1296
 Leu Asp Cys Lys Val Ser Glu Asp Lys Ser Ala Asp Ser Leu Ile Tyr
             420                 425                 430

 gtt cca ttg tat gtg aca att tgc ttt ttc ctt gct gct ttc agc act     1344
 Val Pro Leu Tyr Val Thr Ile Cys Phe Phe Leu Ala Ala Phe Ser Thr
         435                 440                 445

 ttc act ttg tct tta act ttt gac aat ttg att atg atg tgt ctt gat     1392
 Phe Thr Leu Ser Leu Thr Phe Asp Asn Leu Ile Met Met Cys Leu Asp
     450                 455                 460

 gtg ggt ctc ttt gga ttt atc att tgc tgt act ttg ggc ttc ttg gat     1440
 Val Gly Leu Phe Gly Phe Ile Ile Cys Cys Thr Leu Gly Phe Leu Asp
 465                 470                 475                 480

 ctg gct ttt aat ttc ctt tcc tag                                     1464
 Leu Ala Phe Asn Phe Leu Ser 
                 485





      <210> 428
      <211> 1119
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(1038)

      <400> 428
  atg aag cgt cag ctc aca cac ctt cct ggc cgg ttc tgg ctg tgg ccc      48
  Met Lys Arg Gln Leu Thr His Leu Pro Gly Arg Phe Trp Leu Trp Pro
    1               5                  10                  15

 agc ttc tct gta gcg tcc ctc cta tcc cac cag acc cca gcc aca aat       96
 Ser Phe Ser Val Ala Ser Leu Leu Ser His Gln Thr Pro Ala Thr Asn
              20                  25                  30

 tcc tgg ctt gct tct tcc aaa ctt cat tca gcc cca ggg atg gct ctg      144
 Ser Trp Leu Ala Ser Ser Lys Leu His Ser Ala Pro Gly Met Ala Leu
          35                  40                  45

 cag gat gtg tgc aag tgg cag tcc cct gac acc cag gga cca tca cct      192
 Gln Asp Val Cys Lys Trp Gln Ser Pro Asp Thr Gln Gly Pro Ser Pro
      50                  55                  60

 cac ctg cct cgg gct ggc ggc tgg gct gtg ccc cgg ggt tgt gac cct      240
 His Leu Pro Arg Ala Gly Gly Trp Ala Val Pro Arg Gly Cys Asp Pro
  65                  70                  75                  80

 caa acc ttc ctg cag atc cat ggc ccc aga ctg gcc cac ggc acc acc      288
 Gln Thr Phe Leu Gln Ile His Gly Pro Arg Leu Ala His Gly Thr Thr
                  85                  90                  95

 act ctg gcc ttc cgc ttc cgt cat gga gtc att gct gca gct gac acg      336
 Thr Leu Ala Phe Arg Phe Arg His Gly Val Ile Ala Ala Ala Asp Thr
             100                 105                 110

 cgt tcc tcc tgt ggc agc tat gtg gcg tgt cca gcc tca tgc aag gtc      384
 Arg Ser Ser Cys Gly Ser Tyr Val Ala Cys Pro Ala Ser Cys Lys Val
         115                 120                 125

 atc cct gtg cac cag cac ctc ctg ggt acc acc tct ggc acc tcc gcc      432
 Ile Pro Val His Gln His Leu Leu Gly Thr Thr Ser Gly Thr Ser Ala
     130                 135                 140

 gac tgt gct acc tgg tat cgg gta tta cag cgg gag ctg cgg ctt cgg      480
 Asp Cys Ala Thr Trp Tyr Arg Val Leu Gln Arg Glu Leu Arg Leu Arg
 145                 150                 155                 160

 gaa ctg agg gag ggt cag ctg ccc agt gtg gcc agt gct gcc aag ctc      528
 Glu Leu Arg Glu Gly Gln Leu Pro Ser Val Ala Ser Ala Ala Lys Leu
                 165                 170                 175

 ttg tca gcc atg atg tct caa tac cgg gga ctg gat ctc tgt gtg gcc      576
 Leu Ser Ala Met Met Ser Gln Tyr Arg Gly Leu Asp Leu Cys Val Ala
             180                 185                 190

 act gcc ctc tgc ggc tgg gac cgc tct ggc cct gag ctc ttc tac gtc      624
 Thr Ala Leu Cys Gly Trp Asp Arg Ser Gly Pro Glu Leu Phe Tyr Val
         195                 200                 205

 tat agc gac ggc acc cgc ctg cag ggg gac atc ttc tct gtg ggc tct      672
 Tyr Ser Asp Gly Thr Arg Leu Gln Gly Asp Ile Phe Ser Val Gly Ser
     210                 215                 220

 gga tct ccc tat gcc tac ggc gtg cta gac cgt ggc tat cgc tac gac      720
 Gly Ser Pro Tyr Ala Tyr Gly Val Leu Asp Arg Gly Tyr Arg Tyr Asp
 225                 230                 235                 240

 atg agc acc cag gaa gcc tac gcc ctg gct cgc tgc gcc gtg gcc cac      768
 Met Ser Thr Gln Glu Ala Tyr Ala Leu Ala Arg Cys Ala Val Ala His
                 245                 250                 255

 gcc acc cac cgt gat gcc tat tca ggg ggc tct gta gac ctt ttc cac      816
 Ala Thr His Arg Asp Ala Tyr Ser Gly Gly Ser Val Asp Leu Phe His
             260                 265                 270

 gtg cgg gag agt gga tgg gag cat gtg tca cgc agt gat gcc tgt gtg      864
 Val Arg Glu Ser Gly Trp Glu His Val Ser Arg Ser Asp Ala Cys Val
         275                 280                 285

 ctg tac gtg gag tta cag aag ctc ctg gag ccg gag cca gag gag gat      912
 Leu Tyr Val Glu Leu Gln Lys Leu Leu Glu Pro Glu Pro Glu Glu Asp
     290                 295                 300

 gcc agc cat gcc cat cct gag cct gcc act gcc cac aga gct gca gaa      960
 Ala Ser His Ala His Pro Glu Pro Ala Thr Ala His Arg Ala Ala Glu
 305                 310                 315                 320

 gat aga gag ctc tct gtg ggg cca ggg gag gtg aca cca gga gac tcc     1008
 Asp Arg Glu Leu Ser Val Gly Pro Gly Glu Val Thr Pro Gly Asp Ser
                 325                 330                 335

 agg atg cca gca ggg act gag acg gtg tga g aagcaggact tggttgggga     1059
 Arg Met Pro Ala Gly Thr Glu Thr Val 
             340                 345

 tggtgtaggc ctggggagtg ggtgggagga tgggcagcag ggggagggtc ccgctggcag   1119




      <210> 429
      <211> 988
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (47)..(988)

      <220>
      <221> misc_feature
      <222> (1)...(988)
      <223> n = a,t,c or g

      <400> 429
 ggtttttacc tctgtnccct gactctcctt tatagaagtg ctctcc   atg gag caa      55
                                                      Met Glu Gln
                                                        1

 gtc aat aag act gtg gtg aga gag ttc gtc gtc ctc ggc ttc tca tcc      103
 Val Asn Lys Thr Val Val Arg Glu Phe Val Val Leu Gly Phe Ser Ser
       5                  10                  15

 ctg gcc agg ctg cag cag ctg ctc ttt gtt atc ttc ctg ctc ctc tac      151
 Leu Ala Arg Leu Gln Gln Leu Leu Phe Val Ile Phe Leu Leu Leu Tyr
  20                  25                  30                  35

 ctg ttc act ctg ggc acc aat gca atc atc att tcc acc att gtg ctg      199
 Leu Phe Thr Leu Gly Thr Asn Ala Ile Ile Ile Ser Thr Ile Val Leu
                  40                  45                  50

 gac aga gcc ctt cat act ccc atg tac ttc ttc ctt gcc atc ctt tct      247
 Asp Arg Ala Leu His Thr Pro Met Tyr Phe Phe Leu Ala Ile Leu Ser
              55                  60                  65

 tgc tct gag att tgc tat acc ttt gtc att gta ccc aag atg ctg gtt      295
 Cys Ser Glu Ile Cys Tyr Thr Phe Val Ile Val Pro Lys Met Leu Val
          70                  75                  80

 gac ctg ctg tcc cag aag aag acc att tct ttc ctg ggc tgt gcc atc      343
 Asp Leu Leu Ser Gln Lys Lys Thr Ile Ser Phe Leu Gly Cys Ala Ile
      85                  90                  95

 caa atg ttt tcc ttc ctc ttc ttt ggc tcc tct cac tcc ttc ctg ctg      391
 Gln Met Phe Ser Phe Leu Phe Phe Gly Ser Ser His Ser Phe Leu Leu
 100                 105                 110                 115

 gca gcc atg ggc tat gat cgc tat atg gcc atc tgt aac cca ctg cgc      439
 Ala Ala Met Gly Tyr Asp Arg Tyr Met Ala Ile Cys Asn Pro Leu Arg
                 120                 125                 130

 tac tca gtg ctc atg gga cat ggg gtg tgt atg gga cta atg gct gct      487
 Tyr Ser Val Leu Met Gly His Gly Val Cys Met Gly Leu Met Ala Ala
             135                 140                 145

 gcc tgt gcc tgt ggc ttc act gtc tcc ctg gtc acc acc tcc cta gta      535
 Ala Cys Ala Cys Gly Phe Thr Val Ser Leu Val Thr Thr Ser Leu Val
         150                 155                 160

 ttt cat ctg ccc ttc cac tcc tcc aac cag ctc cat cac ttc ttc tgt      583
 Phe His Leu Pro Phe His Ser Ser Asn Gln Leu His His Phe Phe Cys
     165                 170                 175

 gac atc tcc cct gtc ctt aaa ctg gca tct cag cac tcc ggc ttc agt      631
 Asp Ile Ser Pro Val Leu Lys Leu Ala Ser Gln His Ser Gly Phe Ser
 180                 185                 190                 195

 cag ctg gtc ata ttc atg ctt ggt gta ttt gcc ttg gtc att cct ctg      679
 Gln Leu Val Ile Phe Met Leu Gly Val Phe Ala Leu Val Ile Pro Leu
                 200                 205                 210

 cta ctt atc cta gtc tcc tac atc cgc atc atc tct gcc att cta aaa      727
 Leu Leu Ile Leu Val Ser Tyr Ile Arg Ile Ile Ser Ala Ile Leu Lys
             215                 220                 225

 atc cct tcc tcc gtt gga aga tac aag acc ttc tcc acc tgt gcc tcc      775
 Ile Pro Ser Ser Val Gly Arg Tyr Lys Thr Phe Ser Thr Cys Ala Ser
         230                 235                 240

 cat ctc att gtg gta act gtt cac tac agt tgt gcc tct ttc atc tac      823
 His Leu Ile Val Val Thr Val His Tyr Ser Cys Ala Ser Phe Ile Tyr
     245                 250                 255

 tta agg ccc aag act aat tac act tca agc caa gac acc cta ata tct      871
 Leu Arg Pro Lys Thr Asn Tyr Thr Ser Ser Gln Asp Thr Leu Ile Ser
 260                 265                 270                 275

 gtg tca tac acc atc ctt acc cca ttg ttc aat cca atg att tat agt      919
 Val Ser Tyr Thr Ile Leu Thr Pro Leu Phe Asn Pro Met Ile Tyr Ser
                 280                 285                 290

 ctg aga aat aag gaa ttc aaa tca gcc cta cga aga aca atc ggc caa      967
 Leu Arg Asn Lys Glu Phe Lys Ser Ala Leu Arg Arg Thr Ile Gly Gln
             295                 300                 305

 act ttc tat cct ctt agt taa                                          988
 Thr Phe Tyr Pro Leu Ser 
         310





      <210> 430
      <211> 1974
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (117)..(1841)

      <400> 430
 ctgagtacct ctgcggaacc gccccggaat ttccgggtcg acgatttcgt gaggtatcag     60

 ctttctccgc tagttcccac cctggtagtc cttagcccct ggaatgcgtg agggag        116                                                                 
 atg ctt agg gag ttc tcg aag tgg ggc gta gag gca tcg cct ggc aag      164
 Met Leu Arg Glu Phe Ser Lys Trp Gly Val Glu Ala Ser Pro Gly Lys
   1               5                  10                  15

 gcc tgg gag cga aaa aga tct cta ctt cgt gga gcc gtt gga cgc tac      212
 Ala Trp Glu Arg Lys Arg Ser Leu Leu Arg Gly Ala Val Gly Arg Tyr
              20                  25                  30

 cgg gga gcc act ggt ggg gac ctt ttt tgg gcc ccc ttt cct tcg tgg      260
 Arg Gly Ala Thr Gly Gly Asp Leu Phe Trp Ala Pro Phe Pro Ser Trp
          35                  40                  45

 ggt act atg gag ttc cca gaa cac agt cag cag ctg ctg cag agc ctc      308
 Gly Thr Met Glu Phe Pro Glu His Ser Gln Gln Leu Leu Gln Ser Leu
      50                  55                  60

 cgg gag cag cgg tcc cag ggt ttc ctt tgt gac tgc acc gtg atg gtg      356
 Arg Glu Gln Arg Ser Gln Gly Phe Leu Cys Asp Cys Thr Val Met Val
  65                  70                  75                  80

 ggt agt acc cag ttc ttg gcc cat cgg gct gtg ctg gcc tcc tgc agc      404
 Gly Ser Thr Gln Phe Leu Ala His Arg Ala Val Leu Ala Ser Cys Ser
                  85                  90                  95

 cca ttc ttc cag ctt ttc tac aag gag cgg gaa ttg gac aag agg gat      452
 Pro Phe Phe Gln Leu Phe Tyr Lys Glu Arg Glu Leu Asp Lys Arg Asp
             100                 105                 110

 ctg gtg tgt att cac aat gaa att gtc aca gcc cca gcc ttt ggg ctg      500
 Leu Val Cys Ile His Asn Glu Ile Val Thr Ala Pro Ala Phe Gly Leu
         115                 120                 125

 ctt ctg gac ttt atg tat gct ggc cag ctg acc ctg aga ggg gat acc      548
 Leu Leu Asp Phe Met Tyr Ala Gly Gln Leu Thr Leu Arg Gly Asp Thr
     130                 135                 140

 cct gtg gag gat gtg ctg gca gct gcc agc tac ttg cac atg aat gac      596
 Pro Val Glu Asp Val Leu Ala Ala Ala Ser Tyr Leu His Met Asn Asp
 145                 150                 155                 160

 atc gtc aag gtg tgt aag cgg cgg ctt caa gcc cgg gcc ctg gca gag      644
 Ile Val Lys Val Cys Lys Arg Arg Leu Gln Ala Arg Ala Leu Ala Glu
                 165                 170                 175

 gca gac agt acc aag aag gag gag gaa acc aac tca cag ctt cct agt      692
 Ala Asp Ser Thr Lys Lys Glu Glu Glu Thr Asn Ser Gln Leu Pro Ser
             180                 185                 190

 ttg gag ttt ttg tct agt act tcc cgt ggc acc caa cct tcg ttg gca      740
 Leu Glu Phe Leu Ser Ser Thr Ser Arg Gly Thr Gln Pro Ser Leu Ala
         195                 200                 205

 tct gct gag aca tca ggc cac tgg ggc aaa ggg gaa tgg aaa ggc tct      788
 Ser Ala Glu Thr Ser Gly His Trp Gly Lys Gly Glu Trp Lys Gly Ser
     210                 215                 220

 gct gct ccc tca cct act gtc cgt cct cca gat gag cca cca atg tct      836
 Ala Ala Pro Ser Pro Thr Val Arg Pro Pro Asp Glu Pro Pro Met Ser
 225                 230                 235                 240

 agt ggg gct gac act aca cag cct ggc atg gag gtt gac gca cca cat      884
 Ser Gly Ala Asp Thr Thr Gln Pro Gly Met Glu Val Asp Ala Pro His
                 245                 250                 255

 ctg cgg gca cct cat cca cca gtg gct gat gtc tct ctt gcc agc cct      932
 Leu Arg Ala Pro His Pro Pro Val Ala Asp Val Ser Leu Ala Ser Pro
             260                 265                 270

 agt agc tcc act gag acc att cct aca aac tac ttc tct tct ggc atc      980
 Ser Ser Ser Thr Glu Thr Ile Pro Thr Asn Tyr Phe Ser Ser Gly Ile
         275                 280                 285

 tca gca gtt tca ttg gag cca ctg cca tct ctt gat gtg ggt cct gag     1028
 Ser Ala Val Ser Leu Glu Pro Leu Pro Ser Leu Asp Val Gly Pro Glu
     290                 295                 300

 agt ctg agg gtg gtg gaa cca aag gat cct gga gga cca ctg caa ggc     1076
 Ser Leu Arg Val Val Glu Pro Lys Asp Pro Gly Gly Pro Leu Gln Gly
 305                 310                 315                 320

 ttc tat ccc cca gcc tca gcc cca acg tca gcc cca gcc cct gtc tca     1124
 Phe Tyr Pro Pro Ala Ser Ala Pro Thr Ser Ala Pro Ala Pro Val Ser
                 325                 330                 335

 gct cca gtt cca tcc cag gct cca gcc cca gct gaa gct gag ctg gtc     1172
 Ala Pro Val Pro Ser Gln Ala Pro Ala Pro Ala Glu Ala Glu Leu Val
             340                 345                 350

 cag gtg aaa gtt gaa gct att gtg atc tct gat gaa gag act gat gtg     1220
 Gln Val Lys Val Glu Ala Ile Val Ile Ser Asp Glu Glu Thr Asp Val
         355                 360                 365

 tca gat gaa cag cct cag ggt cct gag aga gct ttc cca tct gga gga     1268
 Ser Asp Glu Gln Pro Gln Gly Pro Glu Arg Ala Phe Pro Ser Gly Gly
     370                 375                 380

 gca gtg tat ggg gca cag ccc tcc cag cca gag gct ttt gaa gac cca     1316
 Ala Val Tyr Gly Ala Gln Pro Ser Gln Pro Glu Ala Phe Glu Asp Pro
 385                 390                 395                 400

 ggg gca gca gga ctg gag gag gtg ggg cca agt gac cac ttc ctg cca     1364
 Gly Ala Ala Gly Leu Glu Glu Val Gly Pro Ser Asp His Phe Leu Pro
                 405                 410                 415

 aca gac cct cat cta ccc tac cat ctg ctg cca ggt gca ggg cag tat     1412
 Thr Asp Pro His Leu Pro Tyr His Leu Leu Pro Gly Ala Gly Gln Tyr
             420                 425                 430

 cat cga gga ctg gtg acc tca cct ctg cct gca ccc gca tcc ctg cat     1460
 His Arg Gly Leu Val Thr Ser Pro Leu Pro Ala Pro Ala Ser Leu His
         435                 440                 445

 gag cca ctt tac ctg tct tct gag tac gaa gca gct cca gga agc ttt     1508
 Glu Pro Leu Tyr Leu Ser Ser Glu Tyr Glu Ala Ala Pro Gly Ser Phe
     450                 455                 460

 ggg gtt ttt act gag gat gtt ccc acc tgc aag aca tgt ggg aag acc     1556
 Gly Val Phe Thr Glu Asp Val Pro Thr Cys Lys Thr Cys Gly Lys Thr
 465                 470                 475                 480

 ttc tca tgc tct tac aca cta cgg cga cat gcc acg gtg cac aca cgt     1604
 Phe Ser Cys Ser Tyr Thr Leu Arg Arg His Ala Thr Val His Thr Arg
                 485                 490                 495

 gag cga ccc tat gag tgc cgc tac tgc ctg cgg agc tac acg cag tca     1652
 Glu Arg Pro Tyr Glu Cys Arg Tyr Cys Leu Arg Ser Tyr Thr Gln Ser
             500                 505                 510

 ggg gac ctc tac cgc cac atc cgc aag gct cac aat gag gac ctg gcc     1700
 Gly Asp Leu Tyr Arg His Ile Arg Lys Ala His Asn Glu Asp Leu Ala
         515                 520                 525

 aaa cgc agc aaa cca gat cca gaa gtg gga ccc ctt cta ggg gtg cag     1748
 Lys Arg Ser Lys Pro Asp Pro Glu Val Gly Pro Leu Leu Gly Val Gln
     530                 535                 540

 cct ctc cct ggc tcc cca aca gca gac aga cag agc agc agt ggt gga     1796
 Pro Leu Pro Gly Ser Pro Thr Ala Asp Arg Gln Ser Ser Ser Gly Gly
 545                 550                 555                 560

 ggg cca cct aaa gat ttt gta ttg gcc cca aaa act aac atc taa ggg     1844
 Gly Pro Pro Lys Asp Phe Val Leu Ala Pro Lys Thr Asn Ile 
                 565                 570

 agcatgagct gatgctaggc tgctcttacc atccttagat ggcagctcag aaggttggtg   1904

 gcaccttatc acccctgctg ggtgacaaga ataaaggctc tgcccaggct gaaagttcaa   1964

 aaaaaaaaaa                                                          1974




      <210> 431
      <211> 1006
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (239)..(838)

      <400> 431
 gcagacccgg gcaccgcgga ggctggagcc gcaatggtgc tgatggaggg cgggagatgg     60

 agctgaccag gggccggagg ggctgagaag agcctgccca agtctgggcc aagcacgaag    120

 ccctttccca cccgtcgggc tcctgggttc ccgccagccg atttccagcc gtcagggtca    180

 cgccactcgc tggaaaccct gaactctgtg ccccccaagc cctgggcccc ctgcggga      238                                                                 
 atg ttc aaa aat gag tac cag gga ggt gca ttt gtt gaa att ttc agt      286
 Met Phe Lys Asn Glu Tyr Gln Gly Gly Ala Phe Val Glu Ile Phe Ser
   1               5                  10                  15

 gct caa gga aaa aat cct gga gca aaa tgg aag atc ctt ggt agt cca      334
 Ala Gln Gly Lys Asn Pro Gly Ala Lys Trp Lys Ile Leu Gly Ser Pro
              20                  25                  30

 tct gtg att tgg aaa gag ttt gat aaa gaa gtt aaa agt ttt gtg ttt      382
 Ser Val Ile Trp Lys Glu Phe Asp Lys Glu Val Lys Ser Phe Val Phe
          35                  40                  45

 gtc ctg gaa ggc agc agc caa aca aac aaa att cag tta cca aag gag      430
 Val Leu Glu Gly Ser Ser Gln Thr Asn Lys Ile Gln Leu Pro Lys Glu
      50                  55                  60

 aat aag caa agc ctt gga ttg atc cag agg ttt ctt gta ctt cag att      478
 Asn Lys Gln Ser Leu Gly Leu Ile Gln Arg Phe Leu Val Leu Gln Ile
  65                  70                  75                  80

 tac gta ccc ctg gga caa gac ttc tcc act gaa ttg cta att act gat      526
 Tyr Val Pro Leu Gly Gln Asp Phe Ser Thr Glu Leu Leu Ile Thr Asp
                  85                  90                  95

 tta ggg aac atc aaa aga aga tta tat tta tca acg gtc cat aag gaa      574
 Leu Gly Asn Ile Lys Arg Arg Leu Tyr Leu Ser Thr Val His Lys Glu
             100                 105                 110

 cta tcc tcc acc cct ctt cat gca aaa att cca ctc ttc atg atc aaa      622
 Leu Ser Ser Thr Pro Leu His Ala Lys Ile Pro Leu Phe Met Ile Lys
         115                 120                 125

 cgt aaa att tgg tgc aat cta tgc att gac tta gta gca ttc acc agt      670
 Arg Lys Ile Trp Cys Asn Leu Cys Ile Asp Leu Val Ala Phe Thr Ser
     130                 135                 140

 gaa ata ttc aag ggg gca gtt ttc cag tca ttg gat gga att gtt gtc      718
 Glu Ile Phe Lys Gly Ala Val Phe Gln Ser Leu Asp Gly Ile Val Val
 145                 150                 155                 160

 tca gct aac tgt aag cta cgg aag atc ttc acc tta aaa tca aag cca      766
 Ser Ala Asn Cys Lys Leu Arg Lys Ile Phe Thr Leu Lys Ser Lys Pro
                 165                 170                 175

 caa gac act gct gat aag gat ggt atg ttc agg ttg cta tca aga ttt      814
 Gln Asp Thr Ala Asp Lys Asp Gly Met Phe Arg Leu Leu Ser Arg Phe
             180                 185                 190

 ttt aat tct ctg atg tat ttt taa aattagccat acctttggga tagtatgagt     868
 Phe Asn Ser Leu Met Tyr Phe 
         195

 gtgtggtagc agtttgatgt tatgtctgct aaagtaaatt tgtcaacagt catgctgatt    928

 tctttgttct agatcaaatg tttattttta ctatagctga atgtcacaaa aaaggtatta    988

 atcttcaaaa aaaaaaaa                                                 1006




      <210> 432
      <211> 671
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (30)..(671)

      <400> 432
 cacgctggta caggttcaag gtggtgccc  atg cgt aaa cca tcc cgc cgt aag      53
                                  Met Arg Lys Pro Ser Arg Arg Lys
                                    1               5

 tgc aaa gta tgc ggt gaa tac ttc gtg ccg aaa ttc cac gac atc cgg      101
 Cys Lys Val Cys Gly Glu Tyr Phe Val Pro Lys Phe His Asp Ile Arg
      10                  15                  20

 atc cgg tgg tgc agc ccg gag cat ggc gca atc ctc gca atg gaa gaa      149
 Ile Arg Trp Cys Ser Pro Glu His Gly Ala Ile Leu Ala Met Glu Glu
  25                  30                  35                  40

 cgc aag aag gag aag gtg aaa gcc gcg gct aag cgc atc aag gag caa      197
 Arg Lys Lys Glu Lys Val Lys Ala Ala Ala Lys Arg Ile Lys Glu Gln
                  45                  50                  55

 aaa gag gct gaa aag gac ggg cgc aaa cgc cgc aag gag cgg ctg gca      245
 Lys Glu Ala Glu Lys Asp Gly Arg Lys Arg Arg Lys Glu Arg Leu Ala
              60                  65                  70

 gag ctc agg cca gac gga tac tac aag gct cag gct cag aaa gct ttc      293
 Glu Leu Arg Pro Asp Gly Tyr Tyr Lys Ala Gln Ala Gln Lys Ala Phe
          75                  80                  85

 aac gcc ttt atc cgt gcg cgc gac gcc gat ttg cca tgc atc agc tgc      341
 Asn Ala Phe Ile Arg Ala Arg Asp Ala Asp Leu Pro Cys Ile Ser Cys
      90                  95                 100

 ggc gag acc aat ccg cct gat ctg cat ggt ggc cag tgg gat tgc ggc      389
 Gly Glu Thr Asn Pro Pro Asp Leu His Gly Gly Gln Trp Asp Cys Gly
 105                 110                 115                 120

 cat ttc aag aca gta ggt gct tac cct gaa ctg cgc ttt gaa gaa cgc      437
 His Phe Lys Thr Val Gly Ala Tyr Pro Glu Leu Arg Phe Glu Glu Arg
                 125                 130                 135

 aac gcc cat aag cag tgc aaa tcc tgt aat gcc gga gct ggc aag tac      485
 Asn Ala His Lys Gln Cys Lys Ser Cys Asn Ala Gly Ala Gly Lys Tyr
             140                 145                 150

 acc gcc aaa gag gcg acc gtg gcg cag caa tac gaa gct ggg ttg gtc      533
 Thr Ala Lys Glu Ala Thr Val Ala Gln Gln Tyr Glu Ala Gly Leu Val
         155                 160                 165

 gct cgt tac ggt cag gga tac gtc aac tgg ctc aat ggt ccc cac gaa      581
 Ala Arg Tyr Gly Gln Gly Tyr Val Asn Trp Leu Asn Gly Pro His Glu
     170                 175                 180

 atg acc aac tac cgc cgt gaa gac ttc atc cgg atc cgg gat gag tac      629
 Met Thr Asn Tyr Arg Arg Glu Asp Phe Ile Arg Ile Arg Asp Glu Tyr
 185                 190                 195                 200

 cgc gac aag ctc aaa gca ctg aaa cag cgg gag gca gca tga              671
 Arg Asp Lys Leu Lys Ala Leu Lys Gln Arg Glu Ala Ala 
                 205                 210





      <210> 433
      <211> 2085
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (9)..(1523)

      <400> 433
 ctgccgag atg gag gcg acc ggc acc tgg gcg ctg ctg ctg gcg ctg gcg      50
          Met Glu Ala Thr Gly Thr Trp Ala Leu Leu Leu Ala Leu Ala
            1               5                  10

 ctg ctc ctg ctg ctg acg ctg gcg ctg tcc ggg acc agg gcc cga ggc       98
 Leu Leu Leu Leu Leu Thr Leu Ala Leu Ser Gly Thr Arg Ala Arg Gly
  15                  20                  25                  30

 cac ctg ccc ccc ggg ccc acg ccg cta cca ctg ctg gga aac ctc ctg      146
 His Leu Pro Pro Gly Pro Thr Pro Leu Pro Leu Leu Gly Asn Leu Leu
                  35                  40                  45

 cag cta cgg ccc ggg gcg ctg tat tca ggg ctc atg cgg ctg agt aag      194
 Gln Leu Arg Pro Gly Ala Leu Tyr Ser Gly Leu Met Arg Leu Ser Lys
              50                  55                  60

 aag tac gga ccg gtg ttc acc atc tac ctg gga ccc tgg cgg cct gtg      242
 Lys Tyr Gly Pro Val Phe Thr Ile Tyr Leu Gly Pro Trp Arg Pro Val
          65                  70                  75

 gtg gtc ctg gtt ggg cag gag gct gtg cgg gag gcc ctg gga ggt cag      290
 Val Val Leu Val Gly Gln Glu Ala Val Arg Glu Ala Leu Gly Gly Gln
      80                  85                  90

 gct gag gag ttc agc ggc cgg gga acc gta gcg atg ctg gaa ggg act      338
 Ala Glu Glu Phe Ser Gly Arg Gly Thr Val Ala Met Leu Glu Gly Thr
  95                 100                 105                 110

 ttt gat ggc cat ggg gtt ttc ttc tcc aac ggg gag cgg tgg agg cag      386
 Phe Asp Gly His Gly Val Phe Phe Ser Asn Gly Glu Arg Trp Arg Gln
                 115                 120                 125

 ctg agg aag ttt acc atg ctt gct ctg cgg gac ctg ggc atg ggg aag      434
 Leu Arg Lys Phe Thr Met Leu Ala Leu Arg Asp Leu Gly Met Gly Lys
             130                 135                 140

 cga gaa ggc gag gag ctg atc cag gcg gag gcc cgg tgt ctg gtg gag      482
 Arg Glu Gly Glu Glu Leu Ile Gln Ala Glu Ala Arg Cys Leu Val Glu
         145                 150                 155

 aca ttc cag ggg aca gaa gga cgc cca ttc gat ccc tcc ctg ctg ctg      530
 Thr Phe Gln Gly Thr Glu Gly Arg Pro Phe Asp Pro Ser Leu Leu Leu
     160                 165                 170

 gcc cag gcc acc tcc aac gta gtc tgc tcc ctc ctc ttt ggc ctc cgc      578
 Ala Gln Ala Thr Ser Asn Val Val Cys Ser Leu Leu Phe Gly Leu Arg
 175                 180                 185                 190

 ttc tcc tat gag gat aag gag ttc cag gcc gtg gtc cgg gca gct ggt      626
 Phe Ser Tyr Glu Asp Lys Glu Phe Gln Ala Val Val Arg Ala Ala Gly
                 195                 200                 205

 ggt acc ctg ctg gga gtc agc tcc cag ggg ggt cag acc tac gag atg      674
 Gly Thr Leu Leu Gly Val Ser Ser Gln Gly Gly Gln Thr Tyr Glu Met
             210                 215                 220

 ttc tcc tgg ttc ctg cgg ccc ctg cca ggc ccc cac aag cag ctc ctc      722
 Phe Ser Trp Phe Leu Arg Pro Leu Pro Gly Pro His Lys Gln Leu Leu
         225                 230                 235

 cac cac gtc agc acc ttg gct gcc ttc aca gtc cgg cag gtg cag cag      770
 His His Val Ser Thr Leu Ala Ala Phe Thr Val Arg Gln Val Gln Gln
     240                 245                 250

 cac cag ggg aac ctg gat gct tcg ggc ccc gca cgt gac ctt gtc gat      818
 His Gln Gly Asn Leu Asp Ala Ser Gly Pro Ala Arg Asp Leu Val Asp
 255                 260                 265                 270

 gcc ttc ctg ctg aag atg gca cag gag gaa caa aac cca ggc aca gaa      866
 Ala Phe Leu Leu Lys Met Ala Gln Glu Glu Gln Asn Pro Gly Thr Glu
                 275                 280                 285

 ttc acc aac aag aac atg ctg atg aca gtc att tat ttg ctg ttt gct      914
 Phe Thr Asn Lys Asn Met Leu Met Thr Val Ile Tyr Leu Leu Phe Ala
             290                 295                 300

 ggg acg atg acg gtc agc acc acg gtc ggc tat acc ctc ctg ctc ctg      962
 Gly Thr Met Thr Val Ser Thr Thr Val Gly Tyr Thr Leu Leu Leu Leu
         305                 310                 315

 atg aaa tac cct cat gtc caa aag tgg gta cgt gag gag ctg aat cgg     1010
 Met Lys Tyr Pro His Val Gln Lys Trp Val Arg Glu Glu Leu Asn Arg
     320                 325                 330

 gag ctg ggg gct ggc cag gca cca agc cta ggg gac cgt acc cgc ctc     1058
 Glu Leu Gly Ala Gly Gln Ala Pro Ser Leu Gly Asp Arg Thr Arg Leu
 335                 340                 345                 350

 cct tac acc gac gcg gtt ctg cat gag gcg cag cgg ctg ctg gcg ctg     1106
 Pro Tyr Thr Asp Ala Val Leu His Glu Ala Gln Arg Leu Leu Ala Leu
                 355                 360                 365

 gtg ccc atg gga ata ccc cgc acc ctc atg cgg acc acc cgc ttc cga     1154
 Val Pro Met Gly Ile Pro Arg Thr Leu Met Arg Thr Thr Arg Phe Arg
             370                 375                 380

 ggg tac acc ctg ccc cag ggc acg gag gtc ttc ccc ctc ctt ggc tcc     1202
 Gly Tyr Thr Leu Pro Gln Gly Thr Glu Val Phe Pro Leu Leu Gly Ser
         385                 390                 395

 atc ctg cat gac ccc aac atc ttc aag cac cca gaa gag ttc aac cca     1250
 Ile Leu His Asp Pro Asn Ile Phe Lys His Pro Glu Glu Phe Asn Pro
     400                 405                 410

 gac cgt ttc ctg gat gca gat gga cgg ttc agg aag cat gag gcg ttc     1298
 Asp Arg Phe Leu Asp Ala Asp Gly Arg Phe Arg Lys His Glu Ala Phe
 415                 420                 425                 430

 ctg ccc ttc tcc tta ggg aag cgt gtc tgc ctt gga gag ggc ctg gca     1346
 Leu Pro Phe Ser Leu Gly Lys Arg Val Cys Leu Gly Glu Gly Leu Ala
                 435                 440                 445

 aaa gcg gag ctc ttc ctc ttc ttc acc acc atc cta caa gcc ttc tcc     1394
 Lys Ala Glu Leu Phe Leu Phe Phe Thr Thr Ile Leu Gln Ala Phe Ser
             450                 455                 460

 ctg gag agc ccg tgc ccg ccg gac acc ctg agc ctc aag ccc acc gtc     1442
 Leu Glu Ser Pro Cys Pro Pro Asp Thr Leu Ser Leu Lys Pro Thr Val
         465                 470                 475

 agt ggc ctt ttc aac att ccc cca gcc ttc cag ctg caa gtc cgt ccc     1490
 Ser Gly Leu Phe Asn Ile Pro Pro Ala Phe Gln Leu Gln Val Arg Pro
     480                 485                 490

 act gac ctt cac tcc acc acg cag acc aga tga aggaaggc aacttggaag     1541
 Thr Asp Leu His Ser Thr Thr Gln Thr Arg 
 495                 500

 tggtgggtgc ccaggacggt gcctccagcc tcaacagtgg gcatggacag ggttaatgtc   1601

 tccagagtgt acactgcagg cagccacatt tacacgcctg cagttgtttt ccggagtctg   1661

 tcccacggcc cacacgctca cttgactcat gctgctaaga tgcacaaccg cacacccata   1721

 cacaactaca agggccacaa agcaactgct gggttagctt tccacagaca taaatatagt   1781

 ccatctgcaa tcacaagcac atagccaggt aacccaccaa ctcccctgga tctgcagccc   1841

 acacgtgggg gtctggctgt caccttcaca agccacagaa acggccacac atgttcacag   1901

 ctcacacgcc ctctccattc atcgaacttc tcagtgtccc tgtccctggt gcctggcaca   1961

 gggaacagca tgccccctcc ggggtcatgc cacccagaga ctgtcgctgt ctatggcccc   2021

 aactcatgct ccctctcttg gctacaccac tctcccagcc tgtgaccacc gatgtccaca   2081

 cacc                                                                2085




      <210> 434
      <211> 1714
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (89)..(1714)

      <400> 434
 tcgacgattt cgttctgcaa tgactcctcc ttggacttcg ccgaccgcca cccttgcgta     60

 tcaaacactc cgccaagccc ccctcacc   atg gtc cac tcc cca cct gtc ctg     112
                                  Met Val His Ser Pro Pro Val Leu
                                    1               5

 cct ttg tgt gcc tct gtg tct ttg ctg ggt ggc ctg acc ttt ggt tat      160
 Pro Leu Cys Ala Ser Val Ser Leu Leu Gly Gly Leu Thr Phe Gly Tyr
      10                  15                  20

 gaa ctg gca gtc ata tca ggt gtc ctg ctg cca ctg cag ctt gac ttt      208
 Glu Leu Ala Val Ile Ser Gly Val Leu Leu Pro Leu Gln Leu Asp Phe
  25                  30                  35                  40

 ggg cta agc tgc ttg gag cag gag ttc ctg gtg ggc agc ctg ctc ctg      256
 Gly Leu Ser Cys Leu Glu Gln Glu Phe Leu Val Gly Ser Leu Leu Leu
                  45                  50                  55

 ggg gct ctc ctc gcc tcc ctg gtt ggt ggc ttc ctc att gac tgc tat      304
 Gly Ala Leu Leu Ala Ser Leu Val Gly Gly Phe Leu Ile Asp Cys Tyr
              60                  65                  70

 ggc agg aag caa gcc atc ctc ggg agc aac ttg gtg ctg ctg gca ggc      352
 Gly Arg Lys Gln Ala Ile Leu Gly Ser Asn Leu Val Leu Leu Ala Gly
          75                  80                  85

 agc ctg acc ctg ggc ctg gct ggt tcc ctg gcc tgg ctg gtc ctg ggc      400
 Ser Leu Thr Leu Gly Leu Ala Gly Ser Leu Ala Trp Leu Val Leu Gly
      90                  95                 100

 cgc gct gtg gtt ggc ttc gcc att tcc ctc tcc tcc atg gct tgc tgt      448
 Arg Ala Val Val Gly Phe Ala Ile Ser Leu Ser Ser Met Ala Cys Cys
 105                 110                 115                 120

 atc tac gtg tca gag ctg gtg ggg cca cgg cag cgg gga gtg ctg gtg      496
 Ile Tyr Val Ser Glu Leu Val Gly Pro Arg Gln Arg Gly Val Leu Val
                 125                 130                 135

 tcc ctc tat gag gca ggc atc acc gtg ggc atc ctg ctc tcc tat gcc      544
 Ser Leu Tyr Glu Ala Gly Ile Thr Val Gly Ile Leu Leu Ser Tyr Ala
             140                 145                 150

 ctc aac tat gca ctg gct ggt acc ccc tgg gga tgg agg cac atg ttc      592
 Leu Asn Tyr Ala Leu Ala Gly Thr Pro Trp Gly Trp Arg His Met Phe
         155                 160                 165

 ggc tgg gcc act gca cct gct gtc ctg caa tcc ctc agc ctc ctc ttc      640
 Gly Trp Ala Thr Ala Pro Ala Val Leu Gln Ser Leu Ser Leu Leu Phe
     170                 175                 180

 ctc cct gct ggt aca gat gag act gca aca cac aag gac ctc atc cca      688
 Leu Pro Ala Gly Thr Asp Glu Thr Ala Thr His Lys Asp Leu Ile Pro
 185                 190                 195                 200

 ctc cag gga ggt gag gcc ccc aag ctg ggc ccg ggg agg cca cgg tac      736
 Leu Gln Gly Gly Glu Ala Pro Lys Leu Gly Pro Gly Arg Pro Arg Tyr
                 205                 210                 215

 tcc ttt ctg gac ctc ttc agg gca cgc gat aac atg cga ggc cgg acc      784
 Ser Phe Leu Asp Leu Phe Arg Ala Arg Asp Asn Met Arg Gly Arg Thr
             220                 225                 230

 aca gtg ggc ctg ggg ctg gtg ctc ttc cag caa cta aca ggg cag ccc      832
 Thr Val Gly Leu Gly Leu Val Leu Phe Gln Gln Leu Thr Gly Gln Pro
         235                 240                 245

 aac gtg ctg tgc tat gcc tcc acc atc ttc agc tcc gtt ggt ttc cat      880
 Asn Val Leu Cys Tyr Ala Ser Thr Ile Phe Ser Ser Val Gly Phe His
     250                 255                 260

 ggg gga tcc tca gcc gtg ctg gcc tct gtg ggg ctt ggc gca gtg aag      928
 Gly Gly Ser Ser Ala Val Leu Ala Ser Val Gly Leu Gly Ala Val Lys
 265                 270                 275                 280

 gtg gca gct acc ctg acc gcc atg ggg ctg gtg gac cgt gca ggc cgc      976
 Val Ala Ala Thr Leu Thr Ala Met Gly Leu Val Asp Arg Ala Gly Arg
                 285                 290                 295

 agg gct ctg ttg cta gct ggc tgt gcc ctc atg gcc ctg tct gtc agt     1024
 Arg Ala Leu Leu Leu Ala Gly Cys Ala Leu Met Ala Leu Ser Val Ser
             300                 305                 310

 ggc ata ggc ctc gtc agc ttt gcc gtg ccc atg gac tca ggc cca agc     1072
 Gly Ile Gly Leu Val Ser Phe Ala Val Pro Met Asp Ser Gly Pro Ser
         315                 320                 325

 tgt ctg gct gtg ccc aat gcc acc ggg cag aca ggc ctc cct gga gac     1120
 Cys Leu Ala Val Pro Asn Ala Thr Gly Gln Thr Gly Leu Pro Gly Asp
     330                 335                 340

 tct ggc ctg ctg cag gac tcc tct cta cct ccc att cca agg acc aat     1168
 Ser Gly Leu Leu Gln Asp Ser Ser Leu Pro Pro Ile Pro Arg Thr Asn
 345                 350                 355                 360

 gag gac caa agg gag cca atc ttg tcc act gct aag aaa acc aag ccc     1216
 Glu Asp Gln Arg Glu Pro Ile Leu Ser Thr Ala Lys Lys Thr Lys Pro
                 365                 370                 375

 cat ccc aga tct gga gac ccc tca gcc cct cct cgg ctg gcc ctg agc     1264
 His Pro Arg Ser Gly Asp Pro Ser Ala Pro Pro Arg Leu Ala Leu Ser
             380                 385                 390

 tct gcc ctc cct ggg ccc cct ctg ccc gct cgg ggg cat gca ctg ctg     1312
 Ser Ala Leu Pro Gly Pro Pro Leu Pro Ala Arg Gly His Ala Leu Leu
         395                 400                 405

 cgc tgg acc gca ctg ctg tgc ctg atg gtc ttt gtc agt gcc ttc tcc     1360
 Arg Trp Thr Ala Leu Leu Cys Leu Met Val Phe Val Ser Ala Phe Ser
     410                 415                 420

 ttt ggg ttt ggg cca gtg acc tgg ctt gtc ctc agc gag atc tac cct     1408
 Phe Gly Phe Gly Pro Val Thr Trp Leu Val Leu Ser Glu Ile Tyr Pro
 425                 430                 435                 440

 gtg gag ata cga gga aga gcc ttc gcc ttc tgc aac agc ttc aac tgg     1456
 Val Glu Ile Arg Gly Arg Ala Phe Ala Phe Cys Asn Ser Phe Asn Trp
                 445                 450                 455

 gcg gcc aac ctc ttc atc agc ctc tcc ttc ctc gat ctc att ggc acc     1504
 Ala Ala Asn Leu Phe Ile Ser Leu Ser Phe Leu Asp Leu Ile Gly Thr
             460                 465                 470

 atc ggc ttg tcc tgg acc ttc ctg ctc tac gga ctg acc gct gtc ctc     1552
 Ile Gly Leu Ser Trp Thr Phe Leu Leu Tyr Gly Leu Thr Ala Val Leu
         475                 480                 485

 ggc ctg ggc ttc atc tat tta ttt gtt cct gaa aca aaa ggc cag tcg     1600
 Gly Leu Gly Phe Ile Tyr Leu Phe Val Pro Glu Thr Lys Gly Gln Ser
     490                 495                 500

 ttg gca gag ata gac cag cag ttc cag aag aga cgg ttc acc ctg agc     1648
 Leu Ala Glu Ile Asp Gln Gln Phe Gln Lys Arg Arg Phe Thr Leu Ser
 505                 510                 515                 520

 ttt ggc cac agg cag aac tcc act ggc atc ccg tac agc cgc atc gag     1696
 Phe Gly His Arg Gln Asn Ser Thr Gly Ile Pro Tyr Ser Arg Ile Glu
                 525                 530                 535

 atc tct gcg gcc tcc tga                                             1714
 Ile Ser Ala Ala Ser 
             540





      <210> 435
      <211> 5117
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (521)..(4024)

      <400> 435
 cgaaagccgg ctttgtactc aacagacagg gtagccgcag attgtatgaa aatattggaa     60

 atcaatggct tctatggaat ttcattaaga agcaggatcc acaattgata gggcctcata    120

 atttgatgga ttgggctaag aaaattgtct gaaaaggtgg ggttgcagag tgctggccag    180

 cttccgaccg tctctccctg aagccgcccc gggggaaggt gcggaggacg cagacagcgg    240

 gcccgagagc cgcagcgggg gcgaggagac cagcgtgtgc gagaaatgct gcgccgagtt    300

 cttcaagtgg gcggacttcc tggagcacca gcggagctgc accaagctcc cgcccgtgct    360

 gatcgtgcac gaggacgcgc ccgcgccgcc ccccgaggac ttccccgagc cttcgcccgc    420

 cagctccccc agcgagcgcg ccgaaagcga ggcggccgag gaggcgggtg cggagggcgc    480

 ggagggcgag gccaggccgg tggagaagga ggccgagccc  atg gac gcg gaa ccc     535
                                              Met Asp Ala Glu Pro
                                                1               5

 gcg ggg gac acg cgc gcg ccc cgg ccc ccg cct gcg gcc cct gca ccc      583
 Ala Gly Asp Thr Arg Ala Pro Arg Pro Pro Pro Ala Ala Pro Ala Pro
                  10                  15                  20

 cca acg ccc gcc tac ggc gcg ccc agc acc aac gtg acc ctg gag gcg      631
 Pro Thr Pro Ala Tyr Gly Ala Pro Ser Thr Asn Val Thr Leu Glu Ala
              25                  30                  35

 ctg ctg agc acc aag gtg gcg gtg gcg cag ttc tcg cag ggc gcg cgc      679
 Leu Leu Ser Thr Lys Val Ala Val Ala Gln Phe Ser Gln Gly Ala Arg
          40                  45                  50

 gcg gca ggc ggc tcg gga gca ggt gga ggc gtg gca gct gca gcc gtg      727
 Ala Ala Gly Gly Ser Gly Ala Gly Gly Gly Val Ala Ala Ala Ala Val
      55                  60                  65

 ccc ctg atc ctg gaa cag ctc atg gcc ctg cag cag cag cag atc cac      775
 Pro Leu Ile Leu Glu Gln Leu Met Ala Leu Gln Gln Gln Gln Ile His
  70                  75                  80                  85

 cag ctg cag ctc atc gag cag atc cgc agc cag gtg gcc ctc atg cag      823
 Gln Leu Gln Leu Ile Glu Gln Ile Arg Ser Gln Val Ala Leu Met Gln
                  90                  95                 100

 tgc ccg ccg ccg cgg ccc tca ctc agc ccc gcg gcc gcc ccg agc gca      871
 Cys Pro Pro Pro Arg Pro Ser Leu Ser Pro Ala Ala Ala Pro Ser Ala
             105                 110                 115

 ccg ggc ccg gcc ccc agc cag ctg ccc ggg ctg gcc gcg ctc ccg ctg      919
 Pro Gly Pro Ala Pro Ser Gln Leu Pro Gly Leu Ala Ala Leu Pro Leu
         120                 125                 130

 tcg gcc ggg gcc cct gcc gcc gcc atc gcg ggc tcg ggc ccc gcc gcc      967
 Ser Ala Gly Ala Pro Ala Ala Ala Ile Ala Gly Ser Gly Pro Ala Ala
     135                 140                 145

 ccg gcc gcc ttc gag ggc gcg cag ccg ctg tcc cgg ccc gag tct ggc     1015
 Pro Ala Ala Phe Glu Gly Ala Gln Pro Leu Ser Arg Pro Glu Ser Gly
 150                 155                 160                 165

 gcc agc acc ccc ggc ggc cct gcg gag ccc agc gcg ccc gcc gcc ccc     1063
 Ala Ser Thr Pro Gly Gly Pro Ala Glu Pro Ser Ala Pro Ala Ala Pro
                 170                 175                 180

 agc gcc gcc cct gcc ccc gct gcc ccc gcc ccg gcg cca gcg ccg cag     1111
 Ser Ala Ala Pro Ala Pro Ala Ala Pro Ala Pro Ala Pro Ala Pro Gln
             185                 190                 195

 agc gca gct tcg tcg cag ccg cag agc gca tcc acg ccg cct gcc ctg     1159
 Ser Ala Ala Ser Ser Gln Pro Gln Ser Ala Ser Thr Pro Pro Ala Leu
         200                 205                 210

 gcc ccg ggg tcc ctg ctg ggt gcg gcg ccc ggc ttg cca agt ccg ctt     1207
 Ala Pro Gly Ser Leu Leu Gly Ala Ala Pro Gly Leu Pro Ser Pro Leu
     215                 220                 225

 cta cct cag act tcc gcc agc ggc gtc atc ttc ccc aac ccg ctg gtc     1255
 Leu Pro Gln Thr Ser Ala Ser Gly Val Ile Phe Pro Asn Pro Leu Val
 230                 235                 240                 245

 agc atc gcg gcc acg gcc aac gct ctg gac ccg ctg tcc gcg ctc atg     1303
 Ser Ile Ala Ala Thr Ala Asn Ala Leu Asp Pro Leu Ser Ala Leu Met
                 250                 255                 260

 aag cac cgc aag ggc aag ccg ccc aat gtg tcg gtg ttc gag ccc aaa     1351
 Lys His Arg Lys Gly Lys Pro Pro Asn Val Ser Val Phe Glu Pro Lys
             265                 270                 275

 gcc agc gcc gag gac ccg ttc ttc aag cac aaa tgc cgc ttc tgc gcc     1399
 Ala Ser Ala Glu Asp Pro Phe Phe Lys His Lys Cys Arg Phe Cys Ala
         280                 285                 290

 aag gtc ttc ggc agc gac agc gcg ctc cag atc cac ctg cgc tcg cac     1447
 Lys Val Phe Gly Ser Asp Ser Ala Leu Gln Ile His Leu Arg Ser His
     295                 300                 305

 aca ggc gag cgg ccc ttc aag tgc aac atc tgc ggg aac cgc ttc tcc     1495
 Thr Gly Glu Arg Pro Phe Lys Cys Asn Ile Cys Gly Asn Arg Phe Ser
 310                 315                 320                 325

 acc aaa ggc aac ctg aag gtg cac ttc cag agg cac aag gag aag tac     1543
 Thr Lys Gly Asn Leu Lys Val His Phe Gln Arg His Lys Glu Lys Tyr
                 330                 335                 340

 ccc cac atc cag atg aac cct tac ccg gtc ccc gag tac ctg gac aac     1591
 Pro His Ile Gln Met Asn Pro Tyr Pro Val Pro Glu Tyr Leu Asp Asn
             345                 350                 355

 gtg ccc acc tgc tcg ggc atc ccc tac ggc atg tcg ctg ccc ccc gag     1639
 Val Pro Thr Cys Ser Gly Ile Pro Tyr Gly Met Ser Leu Pro Pro Glu
         360                 365                 370

 aag ccc gtg acc acc tgg ctg gac agc aag ccc gtg ctg ccc acc gtg     1687
 Lys Pro Val Thr Thr Trp Leu Asp Ser Lys Pro Val Leu Pro Thr Val
     375                 380                 385

 ccc acg tcc gtg ggg ctg caa ctg ccg ccc act gtc cct ggc gcg cac     1735
 Pro Thr Ser Val Gly Leu Gln Leu Pro Pro Thr Val Pro Gly Ala His
 390                 395                 400                 405

 ggc tac gcc gac tct ccc agc gcc acc cca gcc agc cgc tcc ccg cag     1783
 Gly Tyr Ala Asp Ser Pro Ser Ala Thr Pro Ala Ser Arg Ser Pro Gln
                 410                 415                 420

 agg ccc tcg ccc gcc tcc agc gag tgc gcc tcc ttg tcc cca ggc ctc     1831
 Arg Pro Ser Pro Ala Ser Ser Glu Cys Ala Ser Leu Ser Pro Gly Leu
             425                 430                 435

 aac cac gtg gag tcc ggc gtg tcg gcc acc gcc gag tcc cca cag tcg     1879
 Asn His Val Glu Ser Gly Val Ser Ala Thr Ala Glu Ser Pro Gln Ser
         440                 445                 450

 ctc ctc ggc ggg ccg ccc ctc act aaa gcc gag ccc gtc agc ctg ccc     1927
 Leu Leu Gly Gly Pro Pro Leu Thr Lys Ala Glu Pro Val Ser Leu Pro
     455                 460                 465

 tgc acc aac gcc agg gcc ggg gac gct ccc gtg ggc gcg cag gct agc     1975
 Cys Thr Asn Ala Arg Ala Gly Asp Ala Pro Val Gly Ala Gln Ala Ser
 470                 475                 480                 485

 gct gca ccc aca tcg gtg gac ggc gca ccc acg agc ctc ggc agc ccc     2023
 Ala Ala Pro Thr Ser Val Asp Gly Ala Pro Thr Ser Leu Gly Ser Pro
                 490                 495                 500

 ggg ctg ccc gcc gtc tcc gag cag ttc aag gcc cag ttt ccg ttc ggg     2071
 Gly Leu Pro Ala Val Ser Glu Gln Phe Lys Ala Gln Phe Pro Phe Gly
             505                 510                 515

 ggg ctg cta gac tcg atg caa acg tcg gaa acc tcg aag ctg cag cag     2119
 Gly Leu Leu Asp Ser Met Gln Thr Ser Glu Thr Ser Lys Leu Gln Gln
         520                 525                 530

 ctg gtg gag aac atc gac aag aag atg acg gac ccg aac cag tgc gtc     2167
 Leu Val Glu Asn Ile Asp Lys Lys Met Thr Asp Pro Asn Gln Cys Val
     535                 540                 545

 atc tgc cac cgg gtg ctg agc tgc cag agc gcg ctg aag atg cac tac     2215
 Ile Cys His Arg Val Leu Ser Cys Gln Ser Ala Leu Lys Met His Tyr
 550                 555                 560                 565

 cgg acg cac acg ggg gag cgg ccg ttc aag tgc aag atc tgc ggc cgc     2263
 Arg Thr His Thr Gly Glu Arg Pro Phe Lys Cys Lys Ile Cys Gly Arg
                 570                 575                 580

 gcc ttc acc acc aag ggc aac ctc aag acg cac ttc ggc gtg cac cgt     2311
 Ala Phe Thr Thr Lys Gly Asn Leu Lys Thr His Phe Gly Val His Arg
             585                 590                 595

 gca aag ccg ccc ctg cgc gtg cag cac tcc tgc ccc atc tgc cag aag     2359
 Ala Lys Pro Pro Leu Arg Val Gln His Ser Cys Pro Ile Cys Gln Lys
         600                 605                 610

 aag ttc acc aac gcc gtg gtc ctg cag cag cac atc cgc atg cac atg     2407
 Lys Phe Thr Asn Ala Val Val Leu Gln Gln His Ile Arg Met His Met
     615                 620                 625

 ggc ggc cag atc ccc aac acg ccg ctg ccg gag ggc ttc cag gat gcc     2455
 Gly Gly Gln Ile Pro Asn Thr Pro Leu Pro Glu Gly Phe Gln Asp Ala
 630                 635                 640                 645

 atg gac tcc gag ctg gcc tac gac gac aag aac gcg gag acc ctg agc     2503
 Met Asp Ser Glu Leu Ala Tyr Asp Asp Lys Asn Ala Glu Thr Leu Ser
                 650                 655                 660

 agc tac gat gac gac atg gac gag aac tcc atg gag gac gac gct gag     2551
 Ser Tyr Asp Asp Asp Met Asp Glu Asn Ser Met Glu Asp Asp Ala Glu
             665                 670                 675

 ctg aag gac gcg gcc acc gac ccg gcc aag cca ctc ctg tcc tat gcg     2599
 Leu Lys Asp Ala Ala Thr Asp Pro Ala Lys Pro Leu Leu Ser Tyr Ala
         680                 685                 690

 ggg tcc tgc ccg ccc tcc ccg ccc tcg gtc atc tcc agc att gcc gcc     2647
 Gly Ser Cys Pro Pro Ser Pro Pro Ser Val Ile Ser Ser Ile Ala Ala
     695                 700                 705

 ctg gag aac cag atg aag atg atc gac tcg gtc atg agc tgc cag cag     2695
 Leu Glu Asn Gln Met Lys Met Ile Asp Ser Val Met Ser Cys Gln Gln
 710                 715                 720                 725

 ctg acc ggc ctc aag tcc gtg gag aac ggg tcc ggg gag agt gac cgc     2743
 Leu Thr Gly Leu Lys Ser Val Glu Asn Gly Ser Gly Glu Ser Asp Arg
                 730                 735                 740

 ctg agc aac gac tcc tcg tcg gcc gtg ggc gac ctg gag agc cgc agc     2791
 Leu Ser Asn Asp Ser Ser Ser Ala Val Gly Asp Leu Glu Ser Arg Ser
             745                 750                 755

 gcg ggc agc ccc gcc ctg tcc gag tcc tcg tcc tcg cag gcc ctg tcg     2839
 Ala Gly Ser Pro Ala Leu Ser Glu Ser Ser Ser Ser Gln Ala Leu Ser
         760                 765                 770

 ccg gcc ccc agc aat ggt gag agc ttc cgc tcc aag tcc ccg ggc ctg     2887
 Pro Ala Pro Ser Asn Gly Glu Ser Phe Arg Ser Lys Ser Pro Gly Leu
     775                 780                 785

 ggc gcc ccg gag gag ccc cag gaa atc ccg ctc aag acc gag agg ccg     2935
 Gly Ala Pro Glu Glu Pro Gln Glu Ile Pro Leu Lys Thr Glu Arg Pro
 790                 795                 800                 805

 gac agc cca gcc gcc gcc ccg ggc agc gga ggc gcc cct ggc cgc gcg     2983
 Asp Ser Pro Ala Ala Ala Pro Gly Ser Gly Gly Ala Pro Gly Arg Ala
                 810                 815                 820

 ggc atc aag gag gag gct ccc ttc agc ctg ctg ttc ctg agc agg gag     3031
 Gly Ile Lys Glu Glu Ala Pro Phe Ser Leu Leu Phe Leu Ser Arg Glu
             825                 830                 835

 cgg ggt aag tgt ccc agc act gtg tgt ggt gtc tgt ggc aag cct ttt     3079
 Arg Gly Lys Cys Pro Ser Thr Val Cys Gly Val Cys Gly Lys Pro Phe
         840                 845                 850

 gct tgc aag agc gcg ttg gaa atc cac tac cgc agc cat act aag gag     3127
 Ala Cys Lys Ser Ala Leu Glu Ile His Tyr Arg Ser His Thr Lys Glu
     855                 860                 865

 cgg cca ttc gtc tgc gcg ctc tgc agg cga ggg tgc tcc act atg ggt     3175
 Arg Pro Phe Val Cys Ala Leu Cys Arg Arg Gly Cys Ser Thr Met Gly
 870                 875                 880                 885

 aat tta aaa cag cac tta ctg aca cac aga ttg aaa gag ctg cct tct     3223
 Asn Leu Lys Gln His Leu Leu Thr His Arg Leu Lys Glu Leu Pro Ser
                 890                 895                 900

 cag tta ttt gac ccc aac ttt gct cta ggt ccc agc caa agc act cct     3271
 Gln Leu Phe Asp Pro Asn Phe Ala Leu Gly Pro Ser Gln Ser Thr Pro
             905                 910                 915

 agc ctg atc tcc agc gcc gca ccc acc atg atc aaa atg gaa gtg aac     3319
 Ser Leu Ile Ser Ser Ala Ala Pro Thr Met Ile Lys Met Glu Val Asn
         920                 925                 930

 ggt cac ggc aag gcc atg gcg ctg ggc gag ggt ccc ccg ctg ccc gcg     3367
 Gly His Gly Lys Ala Met Ala Leu Gly Glu Gly Pro Pro Leu Pro Ala
     935                 940                 945

 ggc gtc cag gtc ccc gcc ggg cct cag aca gtg atg ggc ccg ggc ctg     3415
 Gly Val Gln Val Pro Ala Gly Pro Gln Thr Val Met Gly Pro Gly Leu
 950                 955                 960                 965

 gcg ccc atg ctg gcc ccc cca ccg cgc cgg acg ccc aag cag cac aac     3463
 Ala Pro Met Leu Ala Pro Pro Pro Arg Arg Thr Pro Lys Gln His Asn
                 970                 975                 980

 tgc cag tcg tgc ggg aag acc ttc tcc tcg gcc agc gcc ctg cag atc     3511
 Cys Gln Ser Cys Gly Lys Thr Phe Ser Ser Ala Ser Ala Leu Gln Ile
             985                 990                 995

 cat gag cgc acg cac acc ggc gag aag ccg ttc ggc tgc acc atc tgc     3559
 His Glu Arg Thr His Thr Gly Glu Lys Pro Phe Gly Cys Thr Ile Cys
        1000                1005                1010

 ggc cgg gcc ttc acc act aag ggc aac ctc aag gtg cac atg ggg aca     3607
 Gly Arg Ala Phe Thr Thr Lys Gly Asn Leu Lys Val His Met Gly Thr
    1015                1020                1025

 cac atg tgg aat aac gcc ccc gcg aga cgc ggc cgc cgc ctg tct gtg     3655
 His Met Trp Asn Asn Ala Pro Ala Arg Arg Gly Arg Arg Leu Ser Val
1030                1035                1040                1045

 gag aac ccc atg gct ctc cta ggg ggt gat gcc ctg aag ttc tct gaa     3703
 Glu Asn Pro Met Ala Leu Leu Gly Gly Asp Ala Leu Lys Phe Ser Glu
                1050                1055                1060

 atg ttc cag aag gac ctg gca gct cgg gca atg aac gtc gac ccc agt     3751
 Met Phe Gln Lys Asp Leu Ala Ala Arg Ala Met Asn Val Asp Pro Ser
            1065                1070                1075

 ttt tgg aac cag tat gct gca gcc atc act aac ggg ctc gcc atg aag     3799
 Phe Trp Asn Gln Tyr Ala Ala Ala Ile Thr Asn Gly Leu Ala Met Lys
        1080                1085                1090

 aac aac gag atc tcc gtc atc cag aac ggc ggc atc ccc cag ctc ccc     3847
 Asn Asn Glu Ile Ser Val Ile Gln Asn Gly Gly Ile Pro Gln Leu Pro
    1095                1100                1105

 gtg agt ctt ggg ggc agc gcc ctc ccc cct ctg ggc agc atg gcc agt     3895
 Val Ser Leu Gly Gly Ser Ala Leu Pro Pro Leu Gly Ser Met Ala Ser
1110                1115                1120                1125

 ggg atg gac aaa gca cgc act ggc agt agc cca ccc atc gtc agc ttg     3943
 Gly Met Asp Lys Ala Arg Thr Gly Ser Ser Pro Pro Ile Val Ser Leu
                1130                1135                1140

 gac aaa gcg agc tca gaa aca gca gcc agc cgc cca ttc acg cgg ttt     3991
 Asp Lys Ala Ser Ser Glu Thr Ala Ala Ser Arg Pro Phe Thr Arg Phe
            1145                1150                1155

 atc gag gat aac aag gag att ggt atc aac tag ccagtgac tcgctcatct     4042
 Ile Glu Asp Asn Lys Glu Ile Gly Ile Asn 
        1160                1165

 gccctgccca ggcccacgtt ttgaagttgg agcatcaggc ctccgacctt tcttgcctcg   4102

 gttctcatta cactttcacc catagcagaa aacactttgt gcggctgccg agaggtggtc   4162

 ttgtaagcgc tgcatggcgc tcccttcaac agcaagcctg actgttctcg agaactctgc   4222

 aatcttttaa ataagcttcc ttcaaaaaaa aaagtgcttg gaaaaccgcc ttaggaacag   4282

 aaagagctca gaccatgtcc acttcctttc tcctgaaacc taataatctc tccgagggag   4342

 aaaggggttc tctgcggtat tccagtgaaa ctcatttgat ggtttctttt gaattagtta   4402

 gacacttgaa cggtgttttt tagaactctt catgttaaag acgtggttta gtactcccaa   4462

 tgctgtgtat catgacacta tcttcgtctg tagtatttat gatgttaaga taatgcgggt   4522

 aacagacaat ataatagccc cgaccttaaa cgaagctttt gtactgcaga atacatctgg   4582

 ctgtgtgatt ttttttttaa gcaagatttg ttttactata aataagtgga ttatttcaat   4642

 gcaggcaaaa ttgtgaagtt ctgttgggaa agatagcatg cttttcgtgt gcaagtacct   4702

 gtcagtaata agcctttttt tttttttttt ttaatttaaa tgtttgtagc tgctatgtgg   4762

 acagttgttt tctagtgtgg tctgtagccc aataactggg gaacgagtta cagacaaaca   4822

 tcaccgtaaa tgactcacaa cattataaac agttgtgaga aaatatttca cattatcaaa   4882

 gctgtacaat aaaaaggtaa tgtttgtata atgtggttgc aaactcttaa tttatactat   4942

 tgcactttta gtattttgta ttagggaggt ttgtctataa tttgaaaatt taaaaaaatg   5002

 taaagtattt tataaatagt acttcagttt aaggaaaatg ggaaaactgt tacagttcct   5062

 tgttttgtct aatggtcaaa caatattaga aatctctgcc cctcgtgcca agctt        5117




      <210> 436
      <211> 933
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (1)..(933)

      <400> 436
  atg acc cat ctg aag aaa ctt aaa gct gag tgc caa ttc tcc caa aaa      48
  Met Thr His Leu Lys Lys Leu Lys Ala Glu Cys Gln Phe Ser Gln Lys
    1               5                  10                  15

 gaa gta gat aga gga gag aaa gaa gag act tta acc att atg tta aca       96
 Glu Val Asp Arg Gly Glu Lys Glu Glu Thr Leu Thr Ile Met Leu Thr
              20                  25                  30

 ttg gga aac cct gcc cac cat ata gta gtt gtc atg gga aac tgg agc      144
 Leu Gly Asn Pro Ala His His Ile Val Val Val Met Gly Asn Trp Ser
          35                  40                  45

 act gtg act gaa atc acc cta att gcc ttc cca gct ctc ctg gag att      192
 Thr Val Thr Glu Ile Thr Leu Ile Ala Phe Pro Ala Leu Leu Glu Ile
      50                  55                  60

 cga ata tct ctc ttc gtg gtt ctt gtg gta act tac aca tta acg gca      240
 Arg Ile Ser Leu Phe Val Val Leu Val Val Thr Tyr Thr Leu Thr Ala
  65                  70                  75                  80

 aca gga aac atc acc atc atc tcc ctg ata tgg att gat cat cgc ctg      288
 Thr Gly Asn Ile Thr Ile Ile Ser Leu Ile Trp Ile Asp His Arg Leu
                  85                  90                  95

 caa act cca atg tac ttc ttc ctc agt aat ttg tcc ttt ctg gat atc      336
 Gln Thr Pro Met Tyr Phe Phe Leu Ser Asn Leu Ser Phe Leu Asp Ile
             100                 105                 110

 tta tac acc act gtc att acc cca aag ttg ttg gcc tgc ctc cta gga      384
 Leu Tyr Thr Thr Val Ile Thr Pro Lys Leu Leu Ala Cys Leu Leu Gly
         115                 120                 125

 gaa gag aaa acc ata tct ttt gct ggt tgc atg atc caa aca tat ttc      432
 Glu Glu Lys Thr Ile Ser Phe Ala Gly Cys Met Ile Gln Thr Tyr Phe
     130                 135                 140

 tac ttc ttt ctg ggg acg gtg gag ttt atc ctc ttg gcg gtg atg tcc      480
 Tyr Phe Phe Leu Gly Thr Val Glu Phe Ile Leu Leu Ala Val Met Ser
 145                 150                 155                 160

 ttt gac cgc tac atg gct atc tgc gac cca ctg cac tac acg gtc atc      528
 Phe Asp Arg Tyr Met Ala Ile Cys Asp Pro Leu His Tyr Thr Val Ile
                 165                 170                 175

 atg aac agc agg gcc tgc ctt ctg ctg gtt ctg gga tgc tgg gtg gga      576
 Met Asn Ser Arg Ala Cys Leu Leu Leu Val Leu Gly Cys Trp Val Gly
             180                 185                 190

 gcc ttc ctg tct gtg ttg ttt cca acc att gta gtg aca agg cta cct      624
 Ala Phe Leu Ser Val Leu Phe Pro Thr Ile Val Val Thr Arg Leu Pro
         195                 200                 205

 tac tgt agg aaa gaa att aat cat ttc ttc tgt gac att gcc cct ctt      672
 Tyr Cys Arg Lys Glu Ile Asn His Phe Phe Cys Asp Ile Ala Pro Leu
     210                 215                 220

 ctt cag ggc cgt cag aaa gct ttt tct acc tgt gct tct cac atc act      720
 Leu Gln Gly Arg Gln Lys Ala Phe Ser Thr Cys Ala Ser His Ile Thr
 225                 230                 235                 240

 gtt gtc tcc att gcc cac ggg agc aac atc ttt gtg tat gtg aga ccc      768
 Val Val Ser Ile Ala His Gly Ser Asn Ile Phe Val Tyr Val Arg Pro
                 245                 250                 255

 aat cag aac tcc tca ctg gat tat gac aag gtg gcc gct gtc ctc atc      816
 Asn Gln Asn Ser Ser Leu Asp Tyr Asp Lys Val Ala Ala Val Leu Ile
             260                 265                 270

 aca gtg gtg acc cct ctc ctg aac cct ttt atc tac agc ttg agg aat      864
 Thr Val Val Thr Pro Leu Leu Asn Pro Phe Ile Tyr Ser Leu Arg Asn
         275                 280                 285

 gag aag gta cag gaa gtg ttg aga gag aca gtg aac aga atc atg acc      912
 Glu Lys Val Gln Glu Val Leu Arg Glu Thr Val Asn Arg Ile Met Thr
     290                 295                 300

 ttg ata caa agg aaa act tga                                          933
 Leu Ile Gln Arg Lys Thr 
 305                 310





      <210> 437
      <211> 810
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (55)..(810)

      <400> 437
 tttcgtggag tgtcaggttt caatctcagc accagccact cagagcaggg cacg  atg      57
                                                              Met
                                                                1

 ttg ggg gcc cgc ctc agg ctc tgg gtc tgt gcc ttg tgc agc gtc tgc      105
 Leu Gly Ala Arg Leu Arg Leu Trp Val Cys Ala Leu Cys Ser Val Cys
               5                  10                  15

 agc atg agc gtc ctc aga gcc tat ccc aat gcc tcc cca ctg ctc ggc      153
 Ser Met Ser Val Leu Arg Ala Tyr Pro Asn Ala Ser Pro Leu Leu Gly
          20                  25                  30

 tcc agc tgg ggt ggc ctg atc cac ctg tac aca gcc aca gcc agg aac      201
 Ser Ser Trp Gly Gly Leu Ile His Leu Tyr Thr Ala Thr Ala Arg Asn
      35                  40                  45

 agc tac cac ctg cag atc cac aag aat ggc cat gtg gat ggc gca ccc      249
 Ser Tyr His Leu Gln Ile His Lys Asn Gly His Val Asp Gly Ala Pro
  50                  55                  60                  65

 cat cag acc atc tac agt gcc ctg atg atc aga tca gag gat gct ggc      297
 His Gln Thr Ile Tyr Ser Ala Leu Met Ile Arg Ser Glu Asp Ala Gly
                  70                  75                  80

 ttt gtg gtg att aca ggt gtg atg agc aga aga tac ctc tgc atg gat      345
 Phe Val Val Ile Thr Gly Val Met Ser Arg Arg Tyr Leu Cys Met Asp
              85                  90                  95

 ttc aga ggc aac att ttt gga tca cac tat ttc gac ccg gag aac tgc      393
 Phe Arg Gly Asn Ile Phe Gly Ser His Tyr Phe Asp Pro Glu Asn Cys
         100                 105                 110

 agg ttc caa cac cag acg ctg gaa aac ggg tac gac gtc tac cac tct      441
 Arg Phe Gln His Gln Thr Leu Glu Asn Gly Tyr Asp Val Tyr His Ser
     115                 120                 125

 cct cag tat cac ttc ctg gtc agt ctg ggc cgg gcg aag aga gcc ttc      489
 Pro Gln Tyr His Phe Leu Val Ser Leu Gly Arg Ala Lys Arg Ala Phe
 130                 135                 140                 145

 ctg cca ggc atg aac cca ccc ccg tac tcc cag ttc ctg tcc cgg agg      537
 Leu Pro Gly Met Asn Pro Pro Pro Tyr Ser Gln Phe Leu Ser Arg Arg
                 150                 155                 160

 aac gag atc ccc cta att cac ttc aac acc ccc ata cca cgg cgg cac      585
 Asn Glu Ile Pro Leu Ile His Phe Asn Thr Pro Ile Pro Arg Arg His
             165                 170                 175

 acc cgg agc gcc gag gac gac tcg gag cgg gac ccc ctg aac gtg ctg      633
 Thr Arg Ser Ala Glu Asp Asp Ser Glu Arg Asp Pro Leu Asn Val Leu
         180                 185                 190

 aag ccc cgg gcc cgg atg acc ccg gcc ccg gcc tcc tgt tca cag gag      681
 Lys Pro Arg Ala Arg Met Thr Pro Ala Pro Ala Ser Cys Ser Gln Glu
     195                 200                 205

 ctc ccg agc gcc gag gac aac agc ccg atg gcc agt gac cca tta ggg      729
 Leu Pro Ser Ala Glu Asp Asn Ser Pro Met Ala Ser Asp Pro Leu Gly
 210                 215                 220                 225

 gtg gtc agg ggc ggt cga gtg aac acg cac gct ggg gga acg ggc ccg      777
 Val Val Arg Gly Gly Arg Val Asn Thr His Ala Gly Gly Thr Gly Pro
                 230                 235                 240

 gaa ggc tgc cgc ccc ttc gcc aag ttc atc tag                          810
 Glu Gly Cys Arg Pro Phe Ala Lys Phe Ile 
             245                 250





      <210> 438
      <211> 1430
      <212> DNA
      <213> Homo sapiens

      <220>
      <221> CDS
      <222> (104)..(988)

      <400> 438
 gcacgagacc agcagctcac actgaagaag catccttgct tgggtttgca gtcttctgcg     60

 gcaggcattc tcggaggaaa ccagccaagg actaactacg acc  atg aga ttg gca     115
                                                  Met Arg Leu Ala
                                                    1

 gtg att tgc ttt tgc ctg ttt ggc att gcc tcc tcc ctc ccg gtg aaa      163
 Val Ile Cys Phe Cys Leu Phe Gly Ile Ala Ser Ser Leu Pro Val Lys
   5                  10                  15                  20

 gtg act gat tct ggc agc tca gag gag aag ctt tac agc ctg cac cca      211
 Val Thr Asp Ser Gly Ser Ser Glu Glu Lys Leu Tyr Ser Leu His Pro
                  25                  30                  35

 gat cct ata gcc aca tgg ctg gtg cct gac cca tct cag aag cag aat      259
 Asp Pro Ile Ala Thr Trp Leu Val Pro Asp Pro Ser Gln Lys Gln Asn
              40                  45                  50

 ctc ctt gcg cca cag aat gct gtg tcc tct gaa gaa aag gat gac ttt      307
 Leu Leu Ala Pro Gln Asn Ala Val Ser Ser Glu Glu Lys Asp Asp Phe
          55                  60                  65

 aag caa gaa act ctt cca agc aat tcc aat gaa agc cat gac cac atg      355
 Lys Gln Glu Thr Leu Pro Ser Asn Ser Asn Glu Ser His Asp His Met
      70                  75                  80

 gac gac gat gat gac gat gat gat gac gat gga gac cat gca gag agc      403
 Asp Asp Asp Asp Asp Asp Asp Asp Asp Asp Gly Asp His Ala Glu Ser
  85                  90                  95                 100

 gag gat tct gtg gac tcg gat gaa tct gac gaa tct cac cat tcg gat      451
 Glu Asp Ser Val Asp Ser Asp Glu Ser Asp Glu Ser His His Ser Asp
                 105                 110                 115

 gag tct gat gag acc gtc act gct agt aca caa gca gac act ttc act      499
 Glu Ser Asp Glu Thr Val Thr Ala Ser Thr Gln Ala Asp Thr Phe Thr
             120                 125                 130

 cca atc gtc cct aca gtc gat gtc ccc aac ggc cga ggt gat agc ttg      547
 Pro Ile Val Pro Thr Val Asp Val Pro Asn Gly Arg Gly Asp Ser Leu
         135                 140                 145

 gct tat gga ctg agg tca aag tct agg agt ttc cag gtt tct gat gaa      595
 Ala Tyr Gly Leu Arg Ser Lys Ser Arg Ser Phe Gln Val Ser Asp Glu
     150                 155                 160

 cag tat cct gat gcc aca gat gag gac ctc acc tct cac atg aag agc      643
 Gln Tyr Pro Asp Ala Thr Asp Glu Asp Leu Thr Ser His Met Lys Ser
 165                 170                 175                 180

 ggt gag tct aag gag tcc ctc gat gtc atc cct gtt gcc cag ctt ctg      691
 Gly Glu Ser Lys Glu Ser Leu Asp Val Ile Pro Val Ala Gln Leu Leu
                 185                 190                 195

 agc atg ccc tct gat cag gac aac aac gga aag ggc agc cat gag tca      739
 Ser Met Pro Ser Asp Gln Asp Asn Asn Gly Lys Gly Ser His Glu Ser
             200                 205                 210

 agt cag ctg gat gaa cca agt ctg gaa aca cac aga ctt gag cat tcc      787
 Ser Gln Leu Asp Glu Pro Ser Leu Glu Thr His Arg Leu Glu His Ser
         215                 220                 225

 aaa gag agc cag gag agt gcc gat cag tcg gat gtg atc gat agt caa      835
 Lys Glu Ser Gln Glu Ser Ala Asp Gln Ser Asp Val Ile Asp Ser Gln
     230                 235                 240

 gca agt tcc aaa gcc agc ctg gaa cat cag agc cac aag ttt cac agc      883
 Ala Ser Ser Lys Ala Ser Leu Glu His Gln Ser His Lys Phe His Ser
 245                 250                 255                 260

 cac aag gac aag cta gtc cta gac cct aag agt aag gaa gat gat agg      931
 His Lys Asp Lys Leu Val Leu Asp Pro Lys Ser Lys Glu Asp Asp Arg
                 265                 270                 275

 tat ctg aaa ttc cga att tct cat gaa tta gag agt tca tct tct gag      979
 Tyr Leu Lys Phe Arg Ile Ser His Glu Leu Glu Ser Ser Ser Ser Glu
             280                 285                 290

 gtc aac taa agaagag gcaaaaacac agttccttac tttgcattta gtaaaaacaa     1035
 Val Asn 


 gaaaaagtgt tagtgagggt taagcaggaa tactaactgc tcatttctca gttcagtgga   1095

 tatatgtatg tagagaaaga gaggtaatat tttgggctct tagcttagtc tgttgtttca   1155

 tgcaaacacc gttgtaacca aaagcttctg cactttgctt ctgttcttcc tgtacaagaa   1215

 atgcaaacgg ccactgcatt ttaatgattg ttattctttt atgaataaaa tgtatgtaga   1275

 aacaagcaaa tttactgaaa caagcagaat taaaagagaa actgtaacag tctatatcac   1335

 tatacccttt tagttttata attagcatat attttgttgt gattattttt tttgttggtg   1395

 tgaataaatc ttgtaacgaa tgtaaaaaaa aaaaa                              1430




      
